FBXL17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of fatty acid beta-oxidation (GO:0032000)4.20421681
2positive regulation of fatty acid oxidation (GO:0046321)4.07378348
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.04018411
4synaptic vesicle maturation (GO:0016188)3.92918462
5serotonin metabolic process (GO:0042428)3.88607309
6behavioral response to nicotine (GO:0035095)3.83367532
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.79339469
8sarcoplasmic reticulum calcium ion transport (GO:0070296)3.78553238
9monoubiquitinated protein deubiquitination (GO:0035520)3.71545811
10plasma membrane repair (GO:0001778)3.62713326
11regulation of sequestering of triglyceride (GO:0010889)3.59211359
12locomotory exploration behavior (GO:0035641)3.58973925
13primary amino compound metabolic process (GO:1901160)3.58731041
14regulation of skeletal muscle contraction (GO:0014819)3.53537165
15regulation of fatty acid beta-oxidation (GO:0031998)3.51984327
16glutamate secretion (GO:0014047)3.47991775
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.47151161
18response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.45858768
19regulation of synaptic vesicle exocytosis (GO:2000300)3.42173209
20synaptic vesicle exocytosis (GO:0016079)3.40334207
21actin-myosin filament sliding (GO:0033275)3.36860873
22muscle filament sliding (GO:0030049)3.36860873
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.32768810
24regulation of glutamate receptor signaling pathway (GO:1900449)3.31542666
25activation of protein kinase A activity (GO:0034199)3.30797992
26vocalization behavior (GO:0071625)3.27678023
27proline transport (GO:0015824)3.22499291
28membrane depolarization during action potential (GO:0086010)3.22252974
29regulation of membrane repolarization (GO:0060306)3.16609025
30regulation of cell communication by electrical coupling (GO:0010649)3.15958566
31layer formation in cerebral cortex (GO:0021819)3.11994632
32negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.11742722
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10576618
34negative regulation of cell killing (GO:0031342)3.10576618
35response to inactivity (GO:0014854)3.10081318
36regulation of synaptic vesicle transport (GO:1902803)3.09998591
37water-soluble vitamin biosynthetic process (GO:0042364)3.07845705
38positive regulation of synapse maturation (GO:0090129)3.05334207
39regulation of synapse structural plasticity (GO:0051823)3.02938280
40negative regulation of hormone biosynthetic process (GO:0032353)3.01494315
41regulation of fatty acid oxidation (GO:0046320)2.99320594
42regulation of ARF protein signal transduction (GO:0032012)2.96971931
43positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.93121835
44ionotropic glutamate receptor signaling pathway (GO:0035235)2.92949847
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.92822164
46cell differentiation in hindbrain (GO:0021533)2.89280557
47exploration behavior (GO:0035640)2.88229893
48dendrite morphogenesis (GO:0048813)2.87793196
49cellular response to ATP (GO:0071318)2.86062482
50synaptic vesicle docking involved in exocytosis (GO:0016081)2.84714225
51skeletal muscle contraction (GO:0003009)2.83097059
52neurotransmitter secretion (GO:0007269)2.83080706
53regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.82398523
54protein targeting to Golgi (GO:0000042)2.80790865
55regulation of actin filament-based movement (GO:1903115)2.79502723
56relaxation of cardiac muscle (GO:0055119)2.79146075
57cellular potassium ion homeostasis (GO:0030007)2.77469882
58skeletal muscle fiber development (GO:0048741)2.77423765
59neuromuscular synaptic transmission (GO:0007274)2.76672404
60positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.76661765
61cerebellar granule cell differentiation (GO:0021707)2.75304307
62striated muscle contraction (GO:0006941)2.75298748
63neurotransmitter-gated ion channel clustering (GO:0072578)2.75060864
64regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74380230
65regulation of neuronal synaptic plasticity (GO:0048168)2.73948307
66regulation of relaxation of muscle (GO:1901077)2.73065866
67regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.71708026
68negative regulation of systemic arterial blood pressure (GO:0003085)2.71313843
69regulation of potassium ion transmembrane transport (GO:1901379)2.71121844
70neuron cell-cell adhesion (GO:0007158)2.71032008
71negative regulation of appetite (GO:0032099)2.69640986
72negative regulation of response to food (GO:0032096)2.69640986
73actin-mediated cell contraction (GO:0070252)2.69502563
74positive regulation of cardiac muscle cell differentiation (GO:2000727)2.68493891
75mating behavior (GO:0007617)2.68297564
76protein localization to synapse (GO:0035418)2.67855899
77detection of calcium ion (GO:0005513)2.67516497
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65964197
79negative regulation of potassium ion transmembrane transport (GO:1901380)2.65570114
80negative regulation of protein localization to cell surface (GO:2000009)2.63418986
81cardiac muscle contraction (GO:0060048)2.63287315
82regulation of dendritic spine morphogenesis (GO:0061001)2.61744673
83cardiac conduction (GO:0061337)2.61724147
84myofibril assembly (GO:0030239)2.61617611
85regulation of synapse maturation (GO:0090128)2.61437925
86postsynaptic membrane organization (GO:0001941)2.60811012
87sarcomere organization (GO:0045214)2.60512856
88establishment of protein localization to Golgi (GO:0072600)2.60258364
89negative regulation of hormone metabolic process (GO:0032351)2.57928547
90positive regulation of potassium ion transport (GO:0043268)2.57696338
91dendritic spine morphogenesis (GO:0060997)2.57633011
92myotube cell development (GO:0014904)2.56268856
93neuron recognition (GO:0008038)2.55626973
94glutamate receptor signaling pathway (GO:0007215)2.52449651
95gamma-aminobutyric acid transport (GO:0015812)2.52279396
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.51226599
97axonal fasciculation (GO:0007413)2.50600914
98potassium ion homeostasis (GO:0055075)2.50409806
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.50065596
100membrane depolarization (GO:0051899)2.50047873
101cerebellar Purkinje cell layer development (GO:0021680)2.48180852
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.47297520
103vesicle transport along microtubule (GO:0047496)2.47138577
104multicellular organismal signaling (GO:0035637)2.46946656
105retrograde transport, vesicle recycling within Golgi (GO:0000301)2.46381137
106positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.44926707
107neuronal action potential propagation (GO:0019227)2.44397877
108response to gravity (GO:0009629)2.43398675
109nerve growth factor signaling pathway (GO:0038180)2.42535929
110regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.41439690
111pharyngeal system development (GO:0060037)2.41411134
112sodium ion export (GO:0071436)2.41144111
113protein import into peroxisome matrix (GO:0016558)2.40705248
1143-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.38168633
115purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.38168633
116regulation of vesicle fusion (GO:0031338)2.37767031
117regulation of excitatory postsynaptic membrane potential (GO:0060079)2.37681934
118synaptic transmission, glutamatergic (GO:0035249)2.37577172
119neuromuscular process controlling posture (GO:0050884)2.37063121
120alanine transport (GO:0032328)2.36309041
121transmission of nerve impulse (GO:0019226)2.35902333
122calcium-mediated signaling using intracellular calcium source (GO:0035584)2.35755279
123innervation (GO:0060384)2.35106454
124regulation of female receptivity (GO:0045924)2.34993082
125positive regulation of muscle hypertrophy (GO:0014742)2.34347834
126positive regulation of cardiac muscle hypertrophy (GO:0010613)2.34347834
127regulation of dendritic spine development (GO:0060998)2.33724570
128positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.32896258
129suckling behavior (GO:0001967)2.31658764
130regulation of postsynaptic membrane potential (GO:0060078)2.29564075
131clathrin coat assembly (GO:0048268)2.27121572
132organelle transport along microtubule (GO:0072384)2.26661289
133positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.24874776
134neuron-neuron synaptic transmission (GO:0007270)2.23921366
135regulation of calcium ion-dependent exocytosis (GO:0017158)2.23861436
136erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.23560695
137L-phenylalanine catabolic process (GO:0006559)2.23560695
138establishment of nucleus localization (GO:0040023)2.22775684
139positive regulation of potassium ion transmembrane transport (GO:1901381)2.22266095
140endoplasmic reticulum organization (GO:0007029)2.21455431
141regulation of synaptic plasticity (GO:0048167)2.20421719
142potassium ion import (GO:0010107)2.19685045
143regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.18772435
144cerebellar Purkinje cell differentiation (GO:0021702)2.17992218
145neurotransmitter transport (GO:0006836)2.16427336
146presynaptic membrane assembly (GO:0097105)2.16401099
147gamma-aminobutyric acid signaling pathway (GO:0007214)2.16400660
148cellular sodium ion homeostasis (GO:0006883)2.16382295
149regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.16308361
150intraspecies interaction between organisms (GO:0051703)2.15282135
151social behavior (GO:0035176)2.15282135
152cell communication by electrical coupling (GO:0010644)2.14770822
153regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.13873450
154long-term memory (GO:0007616)2.13215220
155neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.11977824
156neuromuscular process controlling balance (GO:0050885)2.11861799
157dicarboxylic acid biosynthetic process (GO:0043650)2.11650237
158long-term synaptic potentiation (GO:0060291)2.11353139
159female mating behavior (GO:0060180)2.10718919
160inner ear receptor cell development (GO:0060119)2.09875471
161erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.09851326
162L-phenylalanine metabolic process (GO:0006558)2.09851326
163prepulse inhibition (GO:0060134)2.09460151
164regulation of synaptic transmission, glutamatergic (GO:0051966)2.09350277
165regulation of cAMP-dependent protein kinase activity (GO:2000479)2.08780477
166regulation of calcium ion transmembrane transporter activity (GO:1901019)2.08233725
167regulation of calcium ion transmembrane transport (GO:1903169)2.08233725
168regulation of neurotransmitter levels (GO:0001505)2.07646703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.74576746
2GBX2_23144817_ChIP-Seq_PC3_Human2.68537852
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32411617
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24863602
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17846857
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10490476
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07429631
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05508387
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.04115954
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01386971
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01077773
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00113197
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00113197
14SMAD_19615063_ChIP-ChIP_OVARY_Human1.99998342
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97060828
16DROSHA_22980978_ChIP-Seq_HELA_Human1.93150578
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88896964
18AR_21572438_ChIP-Seq_LNCaP_Human1.85812024
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82928891
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81398186
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80329924
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.79958875
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.70128225
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63078254
25* REST_21632747_ChIP-Seq_MESCs_Mouse1.62442290
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.61639778
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60805179
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.57333206
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.57315220
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55406070
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55398117
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54685456
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.50713539
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49353242
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47335903
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47042838
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45190891
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.43503702
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42121544
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.39196734
41* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38760797
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37807969
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.35602250
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34881865
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33036144
46TP53_16413492_ChIP-PET_HCT116_Human1.32085544
47* TAF15_26573619_Chip-Seq_HEK293_Human1.32054320
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31439001
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31165771
50P300_19829295_ChIP-Seq_ESCs_Human1.30039624
51* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29112214
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28809068
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.28223875
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26659347
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26440722
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25414223
57STAT3_23295773_ChIP-Seq_U87_Human1.24980070
58AR_25329375_ChIP-Seq_VCAP_Human1.23646409
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21999222
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.21548881
61* SMAD3_21741376_ChIP-Seq_EPCs_Human1.20387654
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.18211049
63* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17454162
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.17056265
65BCAT_22108803_ChIP-Seq_LS180_Human1.16430764
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15588668
67* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14995325
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.14586467
69RNF2_27304074_Chip-Seq_NSC_Mouse1.13847799
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.13223514
71* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13062450
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12696273
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12503174
74AHR_22903824_ChIP-Seq_MCF-7_Human1.11497086
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10276911
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10276911
77* AR_19668381_ChIP-Seq_PC3_Human1.09773534
78IGF1R_20145208_ChIP-Seq_DFB_Human1.08012575
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07502383
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.07306216
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07114711
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06295617
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06191411
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05903121
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05304093
86ZNF274_21170338_ChIP-Seq_K562_Hela1.04443456
87* SMAD4_21741376_ChIP-Seq_HESCs_Human1.04049714
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02783853
89RXR_22108803_ChIP-Seq_LS180_Human1.01661395
90* TCF4_23295773_ChIP-Seq_U87_Human1.00815633
91* FOXA2_19822575_ChIP-Seq_HepG2_Human0.99548910
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98406825
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97795032
94KDM2B_26808549_Chip-Seq_K562_Human0.97636780
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97354247
96* SMAD3_21741376_ChIP-Seq_HESCs_Human0.97247233
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96718840
98YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96212123
99TP53_18474530_ChIP-ChIP_U2OS_Human0.95479038
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93541170
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92631520
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92104194
103RUNX2_22187159_ChIP-Seq_PCA_Human0.90242724
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90173404
105RING1B_27294783_Chip-Seq_ESCs_Mouse0.89560576
106SMAD3_21741376_ChIP-Seq_ESCs_Human0.89229856
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.88132073
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86239511
109PRDM14_20953172_ChIP-Seq_ESCs_Human0.85765329
110STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85694206
111ERG_21242973_ChIP-ChIP_JURKAT_Human0.85673328
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85583930
113* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85234680
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.84894932
115* KDM2B_26808549_Chip-Seq_REH_Human0.84757833
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84593431
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82385183
118VDR_22108803_ChIP-Seq_LS180_Human0.78937086
119* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77451841
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74546885
121FLI1_21867929_ChIP-Seq_TH2_Mouse0.73539210
122TP53_23651856_ChIP-Seq_MEFs_Mouse0.73072422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.40630121
2MP0004859_abnormal_synaptic_plasticity5.08590297
3MP0003880_abnormal_central_pattern3.20529136
4MP0009780_abnormal_chondrocyte_physiolo3.20433008
5MP0003635_abnormal_synaptic_transmissio3.17922299
6MP0004270_analgesia3.00733107
7MP0002063_abnormal_learning/memory/cond2.53613041
8MP0002837_dystrophic_cardiac_calcinosis2.44159151
9MP0000569_abnormal_digit_pigmentation2.37890732
10MP0009745_abnormal_behavioral_response2.34583014
11MP0005670_abnormal_white_adipose2.24415818
12MP0001968_abnormal_touch/_nociception2.19945157
13MP0003123_paternal_imprinting2.12355331
14MP0002139_abnormal_hepatobiliary_system2.11781314
15MP0002064_seizures2.06749659
16MP0002909_abnormal_adrenal_gland2.02018415
17MP0002572_abnormal_emotion/affect_behav1.95185407
18MP0000013_abnormal_adipose_tissue1.83843131
19MP0004130_abnormal_muscle_cell1.82414130
20MP0001501_abnormal_sleep_pattern1.78769525
21MP0008961_abnormal_basal_metabolism1.78105601
22MP0002877_abnormal_melanocyte_morpholog1.77170733
23MP0001486_abnormal_startle_reflex1.75636162
24MP0005360_urolithiasis1.71819702
25MP0002734_abnormal_mechanical_nocicepti1.69406677
26MP0000751_myopathy1.68943207
27MP0004145_abnormal_muscle_electrophysio1.67806480
28MP0002822_catalepsy1.61789969
29MP0006276_abnormal_autonomic_nervous1.60889293
30MP0004510_myositis1.60884044
31MP0009046_muscle_twitch1.59488677
32MP0005365_abnormal_bile_salt1.59144859
33MP0000749_muscle_degeneration1.58864095
34MP0003329_amyloid_beta_deposits1.58321787
35MP0003300_gastrointestinal_ulcer1.57725189
36MP0002733_abnormal_thermal_nociception1.56453206
37MP0005085_abnormal_gallbladder_physiolo1.54710328
38MP0005187_abnormal_penis_morphology1.52749404
39MP0002106_abnormal_muscle_physiology1.51463472
40MP0002272_abnormal_nervous_system1.51226146
41MP0008775_abnormal_heart_ventricle1.48490149
42MP0001440_abnormal_grooming_behavior1.45815830
43MP0001485_abnormal_pinna_reflex1.45671445
44MP0003045_fibrosis1.42611042
45MP0005535_abnormal_body_temperature1.36094771
46MP0001970_abnormal_pain_threshold1.35789292
47MP0003633_abnormal_nervous_system1.34996856
48MP0004134_abnormal_chest_morphology1.34659877
49MP0000733_abnormal_muscle_development1.33943516
50MP0010329_abnormal_lipoprotein_level1.33336416
51MP0004087_abnormal_muscle_fiber1.33146415
52MP0004924_abnormal_behavior1.32605547
53MP0005386_behavior/neurological_phenoty1.32605547
54MP0005423_abnormal_somatic_nervous1.30997903
55MP0002876_abnormal_thyroid_physiology1.30239155
56MP0005646_abnormal_pituitary_gland1.30158657
57MP0005369_muscle_phenotype1.29518133
58MP0002067_abnormal_sensory_capabilities1.28090817
59MP0004742_abnormal_vestibular_system1.27770406
60MP0005666_abnormal_adipose_tissue1.27510879
61MP0004043_abnormal_pH_regulation1.27448364
62MP0008569_lethality_at_weaning1.26879376
63MP0000537_abnormal_urethra_morphology1.25868453
64MP0000759_abnormal_skeletal_muscle1.24145773
65MP0004858_abnormal_nervous_system1.23036474
66MP0001502_abnormal_circadian_rhythm1.23009000
67MP0002557_abnormal_social/conspecific_i1.22506586
68MP0002735_abnormal_chemical_nociception1.19946369
69MP0004811_abnormal_neuron_physiology1.19022024
70MP0003122_maternal_imprinting1.17813218
71MP0004085_abnormal_heartbeat1.11567445
72MP0010386_abnormal_urinary_bladder1.10141395
73MP0002078_abnormal_glucose_homeostasis1.09758783
74MP0003195_calcinosis1.09118058
75MP0002972_abnormal_cardiac_muscle1.07133957
76MP0001905_abnormal_dopamine_level1.06864239
77MP0002736_abnormal_nociception_after1.06440604
78MP0005623_abnormal_meninges_morphology1.06201164
79MP0003868_abnormal_feces_composition1.05163622
80MP0000750_abnormal_muscle_regeneration1.05159957
81MP0004885_abnormal_endolymph1.05145341
82MP0005167_abnormal_blood-brain_barrier1.04811420
83MP0003690_abnormal_glial_cell1.04189222
84MP0003011_delayed_dark_adaptation1.03481022
85MP0004084_abnormal_cardiac_muscle1.03442548
86MP0004215_abnormal_myocardial_fiber1.02545626
87MP0000747_muscle_weakness1.02402087
88MP0009384_cardiac_valve_regurgitation1.01888715
89MP0000604_amyloidosis1.01497219
90MP0009250_abnormal_appendicular_skeleto1.01173530
91MP0008875_abnormal_xenobiotic_pharmacok1.01016996
92MP0003303_peritoneal_inflammation1.00650009
93MP0003787_abnormal_imprinting0.99393224
94MP0000778_abnormal_nervous_system0.99222107
95MP0003121_genomic_imprinting0.99024232
96MP0003252_abnormal_bile_duct0.98721715
97MP0002971_abnormal_brown_adipose0.98272104
98MP0004036_abnormal_muscle_relaxation0.98069581
99MP0003879_abnormal_hair_cell0.94015175
100MP0008874_decreased_physiological_sensi0.93386079
101MP0002118_abnormal_lipid_homeostasis0.92935394
102MP0001963_abnormal_hearing_physiology0.92280871
103MP0005620_abnormal_muscle_contractility0.91740419
104MP0002066_abnormal_motor_capabilities/c0.91475161
105MP0000955_abnormal_spinal_cord0.90908242
106MP0003172_abnormal_lysosome_physiology0.90040627
107MP0000631_abnormal_neuroendocrine_gland0.89897813
108MP0004142_abnormal_muscle_tone0.89119834
109MP0002184_abnormal_innervation0.89085947
110MP0003631_nervous_system_phenotype0.89069552
111MP0000003_abnormal_adipose_tissue0.88405540
112MP0003183_abnormal_peptide_metabolism0.87553223
113MP0002249_abnormal_larynx_morphology0.86861827
114MP0004133_heterotaxia0.84687653
115MP0001944_abnormal_pancreas_morphology0.82920527
116MP0001299_abnormal_eye_distance/0.82571561
117MP0004484_altered_response_of0.82400239
118MP0001544_abnormal_cardiovascular_syste0.82227149
119MP0005385_cardiovascular_system_phenoty0.82227149
120MP0005375_adipose_tissue_phenotype0.81743294
121MP0000639_abnormal_adrenal_gland0.81565417
122MP0005334_abnormal_fat_pad0.81555032
123MP0001765_abnormal_ion_homeostasis0.81333437
124MP0000534_abnormal_ureter_morphology0.80950914
125MP0001984_abnormal_olfaction0.80857679
126MP0003283_abnormal_digestive_organ0.80418837
127MP0001986_abnormal_taste_sensitivity0.79918047
128MP0002693_abnormal_pancreas_physiology0.79914450
129MP0002160_abnormal_reproductive_system0.78931017
130MP0002108_abnormal_muscle_morphology0.78919364
131MP0002138_abnormal_hepatobiliary_system0.78747316
132MP0000026_abnormal_inner_ear0.78448169
133MP0003075_altered_response_to0.78246800
134MP0002090_abnormal_vision0.78040855
135MP0004185_abnormal_adipocyte_glucose0.77185652
136MP0003638_abnormal_response/metabolism_0.76098226
137MP0000681_abnormal_thyroid_gland0.75759931
138MP0002069_abnormal_eating/drinking_beha0.74126378
139MP0000230_abnormal_systemic_arterial0.73386146
140MP0005551_abnormal_eye_electrophysiolog0.71823641
141MP0005330_cardiomyopathy0.70003689

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.09921783
2Nemaline bodies (HP:0003798)4.86681902
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.80520904
4Cutaneous melanoma (HP:0012056)4.66890798
5Type 1 muscle fiber predominance (HP:0003803)4.28336484
6Focal motor seizures (HP:0011153)4.26420092
7Abnormality of binocular vision (HP:0011514)3.95379785
8Diplopia (HP:0000651)3.95379785
9Bundle branch block (HP:0011710)3.68172174
10Focal seizures (HP:0007359)3.52998831
11Myotonia (HP:0002486)3.50498784
12Asymmetric septal hypertrophy (HP:0001670)3.49337107
13Myokymia (HP:0002411)3.38969839
14Exercise-induced muscle cramps (HP:0003710)3.38509324
15Visual hallucinations (HP:0002367)3.26447878
16Meningioma (HP:0002858)3.20028862
17Abnormality of the calf musculature (HP:0001430)3.16332536
18Epileptic encephalopathy (HP:0200134)3.15765318
19Ulnar deviation of the wrist (HP:0003049)3.06389958
20Sudden death (HP:0001699)3.03839484
21Hypoglycemic seizures (HP:0002173)2.95034634
22Hyperventilation (HP:0002883)2.89465760
23Papilledema (HP:0001085)2.88039157
24Generalized tonic-clonic seizures (HP:0002069)2.86568358
25Myoglobinuria (HP:0002913)2.83499279
26Absence seizures (HP:0002121)2.83404515
27Ventricular fibrillation (HP:0001663)2.78850038
28Atonic seizures (HP:0010819)2.74976506
29Supranuclear gaze palsy (HP:0000605)2.70747482
30EMG: myopathic abnormalities (HP:0003458)2.70678935
31Distal arthrogryposis (HP:0005684)2.70652896
32Hyperthyroidism (HP:0000836)2.70492918
33Ketoacidosis (HP:0001993)2.66398642
34Goiter (HP:0000853)2.66343334
35Muscle fiber splitting (HP:0003555)2.66166636
36Syncope (HP:0001279)2.65428042
37Exercise-induced myalgia (HP:0003738)2.65082844
38Absent phalangeal crease (HP:0006109)2.65055382
39Poor eye contact (HP:0000817)2.63385226
40Impaired social interactions (HP:0000735)2.61447512
41Abnormal social behavior (HP:0012433)2.61447512
42Obstructive sleep apnea (HP:0002870)2.58746496
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.58306656
44Broad-based gait (HP:0002136)2.54267355
45Deep venous thrombosis (HP:0002625)2.51294506
46Macroorchidism (HP:0000053)2.50697340
47Agitation (HP:0000713)2.49879529
48Abnormality of the left ventricular outflow tract (HP:0011103)2.49836309
49Subaortic stenosis (HP:0001682)2.49836309
50Methylmalonic acidemia (HP:0002912)2.49037420
51Drooling (HP:0002307)2.47978124
52Excessive salivation (HP:0003781)2.47978124
53Conjunctival hamartoma (HP:0100780)2.46543474
54Action tremor (HP:0002345)2.45939960
55Febrile seizures (HP:0002373)2.44248585
56Hemiparesis (HP:0001269)2.44005567
57Termporal pattern (HP:0011008)2.43907276
58Insidious onset (HP:0003587)2.43907276
59Dialeptic seizures (HP:0011146)2.39186853
60Depression (HP:0000716)2.38970142
61Round ear (HP:0100830)2.38518020
62Ketosis (HP:0001946)2.34991377
63Cerebral inclusion bodies (HP:0100314)2.34695748
64Rhabdomyolysis (HP:0003201)2.34474920
65Dysmetria (HP:0001310)2.34072623
66Neurofibrillary tangles (HP:0002185)2.34066700
67Hamartoma of the eye (HP:0010568)2.31030541
68Scanning speech (HP:0002168)2.31021333
69Anxiety (HP:0000739)2.30735462
70Hyperkalemia (HP:0002153)2.29556590
71Lymphangioma (HP:0100764)2.29355059
72Impaired vibration sensation in the lower limbs (HP:0002166)2.28599469
73EMG: neuropathic changes (HP:0003445)2.26819473
74Neck muscle weakness (HP:0000467)2.26248929
75Epileptiform EEG discharges (HP:0011182)2.25096014
76Incomplete penetrance (HP:0003829)2.24393858
77Abnormal finger flexion creases (HP:0006143)2.22972075
78Confusion (HP:0001289)2.22968610
79Heart block (HP:0012722)2.22565856
80Hyperinsulinemic hypoglycemia (HP:0000825)2.19705096
81Oligomenorrhea (HP:0000876)2.19304716
82EEG with generalized epileptiform discharges (HP:0011198)2.17149021
83Mutism (HP:0002300)2.17032331
84Truncal ataxia (HP:0002078)2.16416904
85Urinary urgency (HP:0000012)2.16359031
86Progressive cerebellar ataxia (HP:0002073)2.16153402
87Fetal akinesia sequence (HP:0001989)2.13556556
88Hyperglycemia (HP:0003074)2.13484021
89Intention tremor (HP:0002080)2.13325286
90Abnormal eating behavior (HP:0100738)2.11867895
91Xanthomatosis (HP:0000991)2.11809467
92Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.11131139
93Areflexia of lower limbs (HP:0002522)2.10858031
94Blue irides (HP:0000635)2.08546668
95Hypsarrhythmia (HP:0002521)2.07652088
96Abnormality of the axillary hair (HP:0100134)2.07443678
97Abnormality of secondary sexual hair (HP:0009888)2.07443678
98Amblyopia (HP:0000646)2.07434298
99Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.06992801
100Short 1st metacarpal (HP:0010034)2.06992801
101Dysdiadochokinesis (HP:0002075)2.06937210
102Bone cyst (HP:0012062)2.06731775
103Ventricular arrhythmia (HP:0004308)2.06507909
104Muscle hypertrophy of the lower extremities (HP:0008968)2.06309725
105Ankle clonus (HP:0011448)2.06306000
106Frequent falls (HP:0002359)2.03628638
107Calf muscle hypertrophy (HP:0008981)2.03604991
108Skin nodule (HP:0200036)2.03322553
109Symptomatic seizures (HP:0011145)2.03296868
110Hemiplegia (HP:0002301)2.02479879
111Congenital sensorineural hearing impairment (HP:0008527)2.01495147
112Epidermoid cyst (HP:0200040)2.00545886
113Status epilepticus (HP:0002133)2.00026017
114Type II lissencephaly (HP:0007260)1.99409829
115Abnormal atrioventricular conduction (HP:0005150)1.99344562
116Generalized hypopigmentation of hair (HP:0011358)1.99159272
117Abnormality of the common coagulation pathway (HP:0010990)1.98890668
118Torticollis (HP:0000473)1.97032090
119Abnormality of skeletal muscle fiber size (HP:0012084)1.96949199
120Methylmalonic aciduria (HP:0012120)1.95138642
121Prolonged partial thromboplastin time (HP:0003645)1.94597431
122Urinary bladder sphincter dysfunction (HP:0002839)1.92480077
123Myopathic facies (HP:0002058)1.91267698
124Muscle stiffness (HP:0003552)1.90743799
125Neonatal onset (HP:0003623)1.90061921
126Hip contracture (HP:0003273)1.89809362
127Akinesia (HP:0002304)1.87442056
128Postural instability (HP:0002172)1.86349583
129Abnormality of the corticospinal tract (HP:0002492)1.86073671
130Abnormality of the periventricular white matter (HP:0002518)1.85985027
131Scapular winging (HP:0003691)1.85301336
132Impaired smooth pursuit (HP:0007772)1.84863524
133Prolonged QT interval (HP:0001657)1.84327248
134Clumsiness (HP:0002312)1.83605320
135Lower limb amyotrophy (HP:0007210)1.82894721
136Short femoral neck (HP:0100864)1.82598826
137Mucopolysacchariduria (HP:0008155)1.81947565
138Urinary glycosaminoglycan excretion (HP:0003541)1.81947565
139Complement deficiency (HP:0004431)1.80687705
140Limited hip movement (HP:0008800)1.80624413
141Difficulty running (HP:0009046)1.80390849
142Abnormality of the Achilles tendon (HP:0005109)1.79777805
143Subacute progressive viral hepatitis (HP:0006572)1.79240855
144Gaze-evoked nystagmus (HP:0000640)1.77403843
145Genetic anticipation (HP:0003743)1.77323015
146Inappropriate behavior (HP:0000719)1.76807470
147Cerebral hemorrhage (HP:0001342)1.76310671
148Hyporeflexia of lower limbs (HP:0002600)1.76045402
149Abnormality of polysaccharide metabolism (HP:0011012)1.75467620
150Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75467620
151Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75467620
152Resting tremor (HP:0002322)1.75288548
153Distal lower limb muscle weakness (HP:0009053)1.75174838
154Hypoventilation (HP:0002791)1.74020261
155Hepatoblastoma (HP:0002884)1.73277132
156Abnormal EKG (HP:0003115)1.72791714
157Turricephaly (HP:0000262)1.72775581
158Abnormality of the 1st metacarpal (HP:0010009)1.72712551
159Increased variability in muscle fiber diameter (HP:0003557)1.70980012
160Symphalangism affecting the phalanges of the hand (HP:0009773)1.70675772
161Lower limb muscle weakness (HP:0007340)1.69890634
162Polyphagia (HP:0002591)1.69510884
163Abnormality of the lower motor neuron (HP:0002366)1.69324292
164Neuronal loss in central nervous system (HP:0002529)1.69304593
165Insulin-resistant diabetes mellitus (HP:0000831)1.68856545
166Hyperlipoproteinemia (HP:0010980)1.68430029
167Progressive inability to walk (HP:0002505)1.67781819
168Absent speech (HP:0001344)1.67567749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.31792368
2MAP3K93.39119146
3MAP3K43.03225847
4NTRK32.82844578
5EPHA42.67350734
6MAP3K22.51483805
7AKT32.48967796
8MAP2K42.25315863
9MARK12.23988377
10KSR22.14560393
11RIPK42.12286850
12PRKD22.12035383
13DAPK22.11165234
14PRKD31.87714671
15MAP2K71.80768887
16GRK11.77845018
17NTRK11.75070999
18MINK11.73351591
19PAK61.69541190
20INSRR1.64884003
21TRIB31.57169913
22RET1.53729496
23NTRK21.43513768
24CAMK1G1.42730240
25PHKG21.38044976
26PHKG11.38044976
27PIK3CA1.33895241
28TAOK31.30402702
29HIPK21.27390790
30MAP3K131.25858446
31MAP3K61.25245261
32CAMKK11.24581272
33KSR11.24107266
34SIK21.23552763
35CDK51.21351509
36PRKCH1.18879221
37DMPK1.12806585
38FES1.12762176
39TYRO31.11711872
40ADRBK21.08351968
41RIPK11.07520990
42MAP3K11.04744185
43EPHA31.01227852
44ICK1.01188812
45GRK51.00959828
46TAOK11.00578912
47NEK90.99269613
48STK390.99100470
49CAMKK20.98458675
50MARK20.96171595
51PAK30.95900216
52PDGFRA0.91329702
53PDK10.91011583
54STK110.89547632
55CAMK1D0.87846019
56PDPK10.87644609
57LATS10.87035195
58TNK20.86635852
59FER0.85972767
60TAOK20.85605087
61SGK30.84535446
62MAP3K120.84330047
63CSNK1G20.84062013
64MAPK40.82366720
65DAPK10.81482018
66MAPKAPK30.81435480
67JAK10.81182073
68MAP3K70.80672830
69CAMK2A0.80496867
70STK380.77585298
71MAPK130.75334334
72LATS20.74775921
73FGFR30.74619552
74SGK20.74502628
75FGFR20.73756897
76CAMK2G0.72926119
77UHMK10.72617149
78MAPK120.72596642
79SGK2230.72038369
80SGK4940.72038369
81BMPR20.71993303
82JAK20.71835196
83FRK0.70861727
84SGK10.68674299
85FGFR40.68172205
86EEF2K0.64236098
87PRKCG0.64209490
88WNK10.63376880
89PIK3CG0.62950454
90MOS0.60821042
91MUSK0.58808750
92FGR0.58373737
93SIK10.57480423
94ERBB20.57399576
95MAPK70.57368845
96PTK2B0.56569347
97PLK20.56471330
98PDGFRB0.55802019
99CAMK10.55745590
100LMTK20.55733455
101CAMK40.55729320
102PINK10.55684501
103RPS6KA20.54677660
104PRKD10.54191163
105PKN20.53890926
106ARAF0.53612437
107MAP3K110.52894627
108CAMK2D0.52750105
109CDC42BPA0.50977091
110CDK190.50739353
111TIE10.50527810
112MAPKAPK50.49941342
113CASK0.49929953
114WNK40.48594504
115MAP2K10.48342688
116PRKACA0.47100621
117PRKAA10.46881139
118PTK20.46721265
119PRKCE0.46720928
120PTK60.46544450
121RPS6KA30.46004026
122PRKAA20.44092003
123SCYL20.40355238
124CAMK2B0.39508915
125PKN10.39381518
126TTN0.39172405
127RPS6KB10.38407881
128PRKCZ0.38057072
129FYN0.37570148
130MAP2K60.36867263
131TRPM70.35022957
132MAP2K20.34310298

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.50874003
2Nicotine addiction_Homo sapiens_hsa050331.92510092
3Long-term potentiation_Homo sapiens_hsa047201.87181164
4GABAergic synapse_Homo sapiens_hsa047271.83551452
5Insulin secretion_Homo sapiens_hsa049111.82730440
6Circadian entrainment_Homo sapiens_hsa047131.82518162
7Cardiac muscle contraction_Homo sapiens_hsa042601.80308643
8Amphetamine addiction_Homo sapiens_hsa050311.76930002
9Glutamatergic synapse_Homo sapiens_hsa047241.72301865
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69952465
11Synaptic vesicle cycle_Homo sapiens_hsa047211.69720576
12Morphine addiction_Homo sapiens_hsa050321.66964679
13Dopaminergic synapse_Homo sapiens_hsa047281.58578638
14Renin secretion_Homo sapiens_hsa049241.58355535
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57985288
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55647355
17Type II diabetes mellitus_Homo sapiens_hsa049301.52571339
18Olfactory transduction_Homo sapiens_hsa047401.48783508
19Salivary secretion_Homo sapiens_hsa049701.42416708
20Cocaine addiction_Homo sapiens_hsa050301.42318572
21Cholinergic synapse_Homo sapiens_hsa047251.41886195
22GnRH signaling pathway_Homo sapiens_hsa049121.40432392
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35462747
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29413169
25Arginine biosynthesis_Homo sapiens_hsa002201.29307154
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27967565
27Gastric acid secretion_Homo sapiens_hsa049711.27967136
28Oxytocin signaling pathway_Homo sapiens_hsa049211.27059361
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.24056376
30Dorso-ventral axis formation_Homo sapiens_hsa043201.21145680
31Long-term depression_Homo sapiens_hsa047301.20462091
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18043527
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16437783
34cAMP signaling pathway_Homo sapiens_hsa040241.12870602
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10153887
36Estrogen signaling pathway_Homo sapiens_hsa049151.06675226
37Bile secretion_Homo sapiens_hsa049761.06412727
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05440964
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.05321195
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03459005
41Taste transduction_Homo sapiens_hsa047421.03329659
42Serotonergic synapse_Homo sapiens_hsa047261.01684774
43Calcium signaling pathway_Homo sapiens_hsa040200.99181622
44Glioma_Homo sapiens_hsa052140.95884670
45Histidine metabolism_Homo sapiens_hsa003400.95137937
46Phototransduction_Homo sapiens_hsa047440.94425843
47Glucagon signaling pathway_Homo sapiens_hsa049220.93638125
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91595958
49Gap junction_Homo sapiens_hsa045400.91130135
50Butanoate metabolism_Homo sapiens_hsa006500.90084901
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89559927
52Renin-angiotensin system_Homo sapiens_hsa046140.88441587
53Insulin resistance_Homo sapiens_hsa049310.88300753
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.88126681
55Ovarian steroidogenesis_Homo sapiens_hsa049130.85624581
56Dilated cardiomyopathy_Homo sapiens_hsa054140.84603426
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.84553637
58Thyroid hormone synthesis_Homo sapiens_hsa049180.83596868
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82544783
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82350744
61Melanoma_Homo sapiens_hsa052180.80459587
62Melanogenesis_Homo sapiens_hsa049160.79310897
63Glycerolipid metabolism_Homo sapiens_hsa005610.78911236
64beta-Alanine metabolism_Homo sapiens_hsa004100.77056640
65ErbB signaling pathway_Homo sapiens_hsa040120.70714315
66Axon guidance_Homo sapiens_hsa043600.70264437
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69899091
68Insulin signaling pathway_Homo sapiens_hsa049100.68081967
69Prolactin signaling pathway_Homo sapiens_hsa049170.66973366
70Arginine and proline metabolism_Homo sapiens_hsa003300.66219966
71Complement and coagulation cascades_Homo sapiens_hsa046100.65733837
72Pancreatic secretion_Homo sapiens_hsa049720.65668098
73Endometrial cancer_Homo sapiens_hsa052130.65590844
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65172007
75Circadian rhythm_Homo sapiens_hsa047100.64999465
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64142962
77AMPK signaling pathway_Homo sapiens_hsa041520.62945349
78PPAR signaling pathway_Homo sapiens_hsa033200.62597367
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62251051
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.62107631
81Phenylalanine metabolism_Homo sapiens_hsa003600.61969302
82VEGF signaling pathway_Homo sapiens_hsa043700.60828866
83Tryptophan metabolism_Homo sapiens_hsa003800.60568012
84MAPK signaling pathway_Homo sapiens_hsa040100.60213558
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59786776
86Sulfur metabolism_Homo sapiens_hsa009200.59223654
87Collecting duct acid secretion_Homo sapiens_hsa049660.59071513
88Choline metabolism in cancer_Homo sapiens_hsa052310.58495971
89Rap1 signaling pathway_Homo sapiens_hsa040150.58367640
90FoxO signaling pathway_Homo sapiens_hsa040680.57668253
91mTOR signaling pathway_Homo sapiens_hsa041500.57586155
92Linoleic acid metabolism_Homo sapiens_hsa005910.57178396
93Renal cell carcinoma_Homo sapiens_hsa052110.55748524
94Prion diseases_Homo sapiens_hsa050200.55476597
95Fatty acid degradation_Homo sapiens_hsa000710.54965995
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54200524
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.53944571
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53627792
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51229837
100Ras signaling pathway_Homo sapiens_hsa040140.50553526
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.49219961
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46793525
103Starch and sucrose metabolism_Homo sapiens_hsa005000.46546372
104Alzheimers disease_Homo sapiens_hsa050100.46394316
105ABC transporters_Homo sapiens_hsa020100.45552637
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45312598
107Vibrio cholerae infection_Homo sapiens_hsa051100.44830018
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44185129
109Platelet activation_Homo sapiens_hsa046110.43443233
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43182847
111Vitamin digestion and absorption_Homo sapiens_hsa049770.43095793
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42762031
113Inositol phosphate metabolism_Homo sapiens_hsa005620.42167946
114Fatty acid metabolism_Homo sapiens_hsa012120.41913216
115Non-small cell lung cancer_Homo sapiens_hsa052230.41094651
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41062182
117Fatty acid biosynthesis_Homo sapiens_hsa000610.40891947
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40488327
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40425183

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