FBLN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.79683244
2type B pancreatic cell proliferation (GO:0044342)5.20370085
3bone trabecula formation (GO:0060346)5.10061738
4paraxial mesoderm development (GO:0048339)4.81284881
5collagen fibril organization (GO:0030199)4.68603503
6planar cell polarity pathway involved in neural tube closure (GO:0090179)4.33687775
7adhesion of symbiont to host cell (GO:0044650)4.12627989
8virion attachment to host cell (GO:0019062)4.12627989
9cardiac myofibril assembly (GO:0055003)4.11429720
10tooth mineralization (GO:0034505)4.11210224
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.02013065
12extracellular fibril organization (GO:0043206)4.00863811
13sequestering of extracellular ligand from receptor (GO:0035581)3.96763570
14mesenchymal-epithelial cell signaling (GO:0060638)3.96667674
15positive regulation of gastrulation (GO:2000543)3.81704783
16regulation of cardioblast differentiation (GO:0051890)3.77643264
17cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.75618179
18cell migration involved in heart development (GO:0060973)3.73159275
19neuron projection extension involved in neuron projection guidance (GO:1902284)3.70196585
20axon extension involved in axon guidance (GO:0048846)3.70196585
21middle ear morphogenesis (GO:0042474)3.62297431
22positive regulation of endothelial cell apoptotic process (GO:2000353)3.60964826
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.60040195
24dermatan sulfate metabolic process (GO:0030205)3.59821390
25negative regulation of smooth muscle cell migration (GO:0014912)3.54210255
26adhesion of symbiont to host (GO:0044406)3.53024332
27glomerular basement membrane development (GO:0032836)3.52703904
28outer ear morphogenesis (GO:0042473)3.51442074
29regulation of transforming growth factor beta2 production (GO:0032909)3.50877584
30basement membrane organization (GO:0071711)3.49829010
31chondrocyte proliferation (GO:0035988)3.47484903
32trabecula formation (GO:0060343)3.43310598
33fibril organization (GO:0097435)3.32738843
34collagen metabolic process (GO:0032963)3.32646767
35polarized epithelial cell differentiation (GO:0030859)3.31672815
36G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.25741046
37cell proliferation involved in metanephros development (GO:0072203)3.25321145
38hippo signaling (GO:0035329)3.25236020
39endodermal cell differentiation (GO:0035987)3.24503899
40smooth muscle tissue development (GO:0048745)3.22078467
41mesenchymal cell proliferation (GO:0010463)3.21645524
42cellular response to vitamin (GO:0071295)3.21305272
43multicellular organismal macromolecule metabolic process (GO:0044259)3.21082060
44collagen catabolic process (GO:0030574)3.19874084
45negative regulation of leukocyte chemotaxis (GO:0002689)3.17121396
46glomerular filtration (GO:0003094)3.15596421
47notochord development (GO:0030903)3.13816051
48regulation of SMAD protein import into nucleus (GO:0060390)3.13733960
49negative regulation of cardiac muscle tissue growth (GO:0055022)3.12800174
50negative regulation of heart growth (GO:0061117)3.12800174
51embryonic skeletal joint morphogenesis (GO:0060272)3.12429123
52positive regulation of epithelial to mesenchymal transition (GO:0010718)3.11275963
53Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.10951412
54multicellular organismal catabolic process (GO:0044243)3.09253471
55sarcomere organization (GO:0045214)3.08580407
56blood vessel maturation (GO:0001955)3.07727127
57myofibril assembly (GO:0030239)3.07384740
58* extracellular matrix organization (GO:0030198)3.06032063
59multicellular organismal metabolic process (GO:0044236)3.05573627
60* extracellular structure organization (GO:0043062)3.04974410
61epithelial cell-cell adhesion (GO:0090136)3.03870916
62protein retention in ER lumen (GO:0006621)3.03633671
63convergent extension (GO:0060026)3.03005100
64branching involved in salivary gland morphogenesis (GO:0060445)3.02424021
65extracellular matrix assembly (GO:0085029)3.01932420
66renal filtration (GO:0097205)3.01509416
67plasma membrane repair (GO:0001778)3.00982610
68non-canonical Wnt signaling pathway (GO:0035567)3.00808792
69negative regulation of chondrocyte differentiation (GO:0032331)3.00232751
70positive regulation of smoothened signaling pathway (GO:0045880)2.99006288
71vitamin A metabolic process (GO:0006776)2.98908495
72keratan sulfate catabolic process (GO:0042340)2.97966020
73cardiac muscle cell development (GO:0055013)2.97217517
74regulation of establishment of planar polarity (GO:0090175)2.97007517
75mesenchyme development (GO:0060485)2.93740734
76growth hormone secretion (GO:0030252)2.93106618
77extracellular regulation of signal transduction (GO:1900115)2.92711927
78extracellular negative regulation of signal transduction (GO:1900116)2.92711927
79negative regulation of catenin import into nucleus (GO:0035414)2.92386645
80regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.92140195
81eyelid development in camera-type eye (GO:0061029)2.91744628
82regulation of gastrulation (GO:0010470)2.91618124
83apoptotic cell clearance (GO:0043277)2.91412339
84cardiac muscle cell proliferation (GO:0060038)2.89906912
85mesenchyme morphogenesis (GO:0072132)2.88813952
86anterior/posterior axis specification, embryo (GO:0008595)2.88288764
87barbed-end actin filament capping (GO:0051016)2.87089978
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.85749417
89establishment of apical/basal cell polarity (GO:0035089)2.85320146
90metanephric mesenchyme development (GO:0072075)2.85107728
91cardiac cell development (GO:0055006)2.85036865
92cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.84319580
93lung vasculature development (GO:0060426)2.84163598
94protein localization to cell surface (GO:0034394)2.84085188
95mesenchymal cell differentiation involved in renal system development (GO:2001012)2.83654588
96mesenchymal cell differentiation involved in kidney development (GO:0072161)2.83654588
97extracellular matrix disassembly (GO:0022617)2.83207592
98regulation of chemokine-mediated signaling pathway (GO:0070099)2.82725209
99endocardial cushion development (GO:0003197)2.82315850
100lateral sprouting from an epithelium (GO:0060601)2.82134071
101cell migration involved in sprouting angiogenesis (GO:0002042)2.81742061
102outflow tract septum morphogenesis (GO:0003148)2.81138702
103negative regulation of cartilage development (GO:0061037)2.80968147
104negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.80870619
105negative regulation of BMP signaling pathway (GO:0030514)2.80334359
106regulation of heart morphogenesis (GO:2000826)2.79993690
107positive regulation of mesenchymal cell proliferation (GO:0002053)2.79860581
108maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.79433247
109heart trabecula formation (GO:0060347)2.79084994
110lung-associated mesenchyme development (GO:0060484)2.79009130
111pericardium development (GO:0060039)2.77909239
112negative regulation of embryonic development (GO:0045992)2.77322294
113heart morphogenesis (GO:0003007)2.76362167
114anatomical structure regression (GO:0060033)2.74823603
115skin morphogenesis (GO:0043589)2.74257006
116regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.73639250
117positive regulation of SMAD protein import into nucleus (GO:0060391)2.72300614
118retina vasculature morphogenesis in camera-type eye (GO:0061299)2.71841753
119venous blood vessel morphogenesis (GO:0048845)2.71133789
120cell proliferation involved in kidney development (GO:0072111)2.71019892
121glycosaminoglycan catabolic process (GO:0006027)2.70915902
122cochlea morphogenesis (GO:0090103)2.70902314
123respiratory tube development (GO:0030323)2.70494348
124mesonephros development (GO:0001823)2.69014204
125embryonic foregut morphogenesis (GO:0048617)2.68800264
126negative regulation of axon extension involved in axon guidance (GO:0048843)2.68512378
127kidney mesenchyme development (GO:0072074)2.68506757
128peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.68289452
129head development (GO:0060322)2.67675967
130vascular endothelial growth factor signaling pathway (GO:0038084)2.66760377
131regulation of organ formation (GO:0003156)2.66146326
132negative regulation of striated muscle cell apoptotic process (GO:0010664)2.65915821
133negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.65623910
134negative regulation of osteoblast proliferation (GO:0033689)2.65369780
135establishment of planar polarity (GO:0001736)2.65240225
136establishment of tissue polarity (GO:0007164)2.65240225
137regulation of extracellular matrix disassembly (GO:0010715)2.64830467
138embryonic forelimb morphogenesis (GO:0035115)2.64547755
139endothelial cell morphogenesis (GO:0001886)2.64206366
140endocardial cushion morphogenesis (GO:0003203)2.63284369
141positive regulation of stem cell differentiation (GO:2000738)2.62696309
142organ induction (GO:0001759)2.62474689
143atrioventricular valve morphogenesis (GO:0003181)2.60275835
144epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.60216609
145ventricular cardiac muscle cell development (GO:0055015)2.59804266
146actin-myosin filament sliding (GO:0033275)2.59002248
147muscle filament sliding (GO:0030049)2.59002248
148hemidesmosome assembly (GO:0031581)2.58429835
149embryonic cranial skeleton morphogenesis (GO:0048701)2.57973171
150dermatan sulfate biosynthetic process (GO:0030208)2.57646587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.26817488
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.73950139
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.84623224
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.24660270
5CLOCK_20551151_ChIP-Seq_293T_Human3.03981825
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.00217465
7E2F7_22180533_ChIP-Seq_HELA_Human2.78891990
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.53552826
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.51644878
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.49329751
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45439950
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35204696
13* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.33536895
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.29286383
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24156112
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13607330
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09345417
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09209104
19* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09179757
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06796450
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.06404230
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.06190313
23EP300_21415370_ChIP-Seq_HL-1_Mouse2.05994305
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.04801232
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01982920
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00826932
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.99852038
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.98268891
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97786491
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.92630604
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.88568692
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88252188
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.85365863
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84705611
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83163737
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77057357
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.75682293
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.75370375
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.70734513
40AR_21909140_ChIP-Seq_LNCAP_Human1.68298539
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63796746
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.61209930
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60712606
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60712606
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60712606
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.57609591
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54093124
48SA1_22415368_ChIP-Seq_MEFs_Mouse1.52337065
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51423115
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49162891
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47620246
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46793120
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.46684878
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.46337530
55RACK7_27058665_Chip-Seq_MCF-7_Human1.46264110
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.45569096
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.45569096
58MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.42644261
59SMC3_22415368_ChIP-Seq_MEFs_Mouse1.40971574
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40932024
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40640288
62* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40414998
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.39206993
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39182314
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38133484
66* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37621690
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37334920
68BRD4_25478319_ChIP-Seq_HGPS_Human1.37162038
69TCF3_18692474_ChIP-Seq_MESCs_Mouse1.37143749
70CJUN_26792858_Chip-Seq_BT549_Human1.35438678
71* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35177633
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34347872
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34347872
74ATF3_27146783_Chip-Seq_COLON_Human1.32672052
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31992456
76* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31755996
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31064337
78* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28793253
79TP53_22127205_ChIP-Seq_IMR90_Human1.28231933
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27647307
81MYC_18555785_ChIP-Seq_MESCs_Mouse1.27454905
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.27189666
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25971215
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25784515
85TP53_23651856_ChIP-Seq_MEFs_Mouse1.25634177
86MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24220842
87NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24077980
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.22697788
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21619157
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21201913
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21093746
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20865773
93EZH2_22144423_ChIP-Seq_EOC_Human1.20182632
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20144749
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.20066611
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19147036
97* TP53_18474530_ChIP-ChIP_U2OS_Human1.18777755
98KDM2B_26808549_Chip-Seq_K562_Human1.18671494
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18646088
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18460955
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17637405
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.17532640
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16795617
104* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16512621
105ZNF263_19887448_ChIP-Seq_K562_Human1.14507525
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13993188
107* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11779226
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11296872
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.10392257
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09692414
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08921533
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08588543
113* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08375849
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.06813195
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05282300
116NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05206794
117TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04419172
118* LXR_22292898_ChIP-Seq_THP-1_Human1.03714787
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03082181
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03082181
121RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03070575
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03029232
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02697124
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02389101
125EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01887974
126POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01771260
127JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01505980
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01498919
129* TP53_16413492_ChIP-PET_HCT116_Human1.01360928
130OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00863821
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00013274
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99529929
133PIAS1_25552417_ChIP-Seq_VCAP_Human0.99260452
134CTCF_27219007_Chip-Seq_Bcells_Human0.99192150
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99041301
136SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99036586
137RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98775130
138EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98775130
139TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97695516
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97599659
141SMAD_19615063_ChIP-ChIP_OVARY_Human0.97435653
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96918953
143NANOG_21062744_ChIP-ChIP_HESCs_Human0.95522944
144* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95350210
145DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92851136
146CBX2_27304074_Chip-Seq_ESCs_Mouse0.92298244
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92099353
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89639229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.47045849
2MP0005503_abnormal_tendon_morphology5.03098183
3MP0005275_abnormal_skin_tensile4.41946115
4MP0003705_abnormal_hypodermis_morpholog3.34746253
5MP0004272_abnormal_basement_membrane2.75559936
6MP0001958_emphysema2.67316558
7MP0010030_abnormal_orbit_morphology2.62389689
8MP0003279_aneurysm2.57766906
9MP0001542_abnormal_bone_strength2.47491431
10MP0000537_abnormal_urethra_morphology2.13250662
11MP0010368_abnormal_lymphatic_system2.08075298
12MP0003385_abnormal_body_wall2.06549267
13MP0005508_abnormal_skeleton_morphology2.03587990
14MP0000751_myopathy2.03009515
15MP0004084_abnormal_cardiac_muscle1.97852539
16MP0005623_abnormal_meninges_morphology1.90744698
17MP0009053_abnormal_anal_canal1.84834437
18MP0002108_abnormal_muscle_morphology1.74793224
19MP0003566_abnormal_cell_adhesion1.73001829
20MP0001299_abnormal_eye_distance/1.68056804
21MP0003567_abnormal_fetal_cardiomyocyte1.66666174
22MP0003122_maternal_imprinting1.64441394
23MP0000534_abnormal_ureter_morphology1.60987648
24MP0004858_abnormal_nervous_system1.60545601
25MP0009384_cardiac_valve_regurgitation1.59416904
26MP0009250_abnormal_appendicular_skeleto1.58434028
27MP0003941_abnormal_skin_development1.56207923
28MP0002060_abnormal_skin_morphology1.55706801
29MP0003123_paternal_imprinting1.55273217
30MP0003942_abnormal_urinary_system1.51900577
31MP0005023_abnormal_wound_healing1.47537938
32MP0005257_abnormal_intraocular_pressure1.44781519
33MP0000428_abnormal_craniofacial_morphol1.43566840
34MP0003283_abnormal_digestive_organ1.42953463
35MP0002837_dystrophic_cardiac_calcinosis1.42533390
36* MP0003115_abnormal_respiratory_system1.41135767
37* MP0000049_abnormal_middle_ear1.39903019
38MP0005367_renal/urinary_system_phenotyp1.37770015
39MP0000516_abnormal_urinary_system1.37770015
40MP0001348_abnormal_lacrimal_gland1.37406035
41MP0000767_abnormal_smooth_muscle1.30719095
42MP0000750_abnormal_muscle_regeneration1.28542014
43MP0003091_abnormal_cell_migration1.28395913
44MP0002282_abnormal_trachea_morphology1.28179287
45MP0002932_abnormal_joint_morphology1.26542739
46MP0005330_cardiomyopathy1.25592471
47MP0000733_abnormal_muscle_development1.25163377
48MP0006138_congestive_heart_failure1.24070022
49MP0003935_abnormal_craniofacial_develop1.23318879
50MP0003119_abnormal_digestive_system1.21266570
51MP0002254_reproductive_system_inflammat1.19975545
52MP0003937_abnormal_limbs/digits/tail_de1.17029111
53MP0010630_abnormal_cardiac_muscle1.16184596
54MP0005076_abnormal_cell_differentiation1.15268756
55MP0001879_abnormal_lymphatic_vessel1.15023836
56MP0010352_gastrointestinal_tract_polyps1.14196918
57MP0000749_muscle_degeneration1.12882479
58MP0009780_abnormal_chondrocyte_physiolo1.11085534
59MP0005385_cardiovascular_system_phenoty1.09968045
60MP0001544_abnormal_cardiovascular_syste1.09968045
61MP0004087_abnormal_muscle_fiber1.08573591
62MP0000013_abnormal_adipose_tissue1.07904749
63MP0004233_abnormal_muscle_weight1.06971775
64MP0003755_abnormal_palate_morphology1.06856371
65MP0004036_abnormal_muscle_relaxation1.05659887
66MP0004215_abnormal_myocardial_fiber1.04908082
67* MP0002249_abnormal_larynx_morphology1.04409252
68MP0008775_abnormal_heart_ventricle1.02569564
69MP0000762_abnormal_tongue_morphology1.02016130
70MP0005595_abnormal_vascular_smooth1.01806888
71MP0000462_abnormal_digestive_system1.01017162
72MP0002933_joint_inflammation0.98956972
73MP0002111_abnormal_tail_morphology0.98730188
74MP0005369_muscle_phenotype0.98007346
75MP0003950_abnormal_plasma_membrane0.97914289
76MP0002972_abnormal_cardiac_muscle0.97249649
77MP0000432_abnormal_head_morphology0.96885977
78MP0001243_abnormal_dermal_layer0.94813499
79MP0002295_abnormal_pulmonary_circulatio0.92943508
80MP0002896_abnormal_bone_mineralization0.92392453
81* MP0000163_abnormal_cartilage_morphology0.92293927
82* MP0002116_abnormal_craniofacial_bone0.92173060
83MP0002938_white_spotting0.91370133
84MP0010386_abnormal_urinary_bladder0.90989624
85MP0002115_abnormal_skeleton_extremities0.90874494
86* MP0002925_abnormal_cardiovascular_devel0.89532949
87MP0004133_heterotaxia0.89349361
88MP0005620_abnormal_muscle_contractility0.89058345
89MP0004197_abnormal_fetal_growth/weight/0.89017277
90* MP0000266_abnormal_heart_morphology0.88247301
91MP0001849_ear_inflammation0.86066512
92MP0003121_genomic_imprinting0.84917943
93* MP0002128_abnormal_blood_circulation0.84615036
94MP0002109_abnormal_limb_morphology0.83469780
95MP0000566_synostosis0.83420983
96* MP0006054_spinal_hemorrhage0.82833027
97* MP0002085_abnormal_embryonic_tissue0.82436580
98MP0000759_abnormal_skeletal_muscle0.82382346
99MP0002114_abnormal_axial_skeleton0.82076590
100MP0005390_skeleton_phenotype0.81673209
101MP0005197_abnormal_uvea_morphology0.81579395
102MP0002133_abnormal_respiratory_system0.81468655
103MP0005388_respiratory_system_phenotype0.81468655
104* MP0001175_abnormal_lung_morphology0.80803935
105MP0002233_abnormal_nose_morphology0.80343903
106MP0002106_abnormal_muscle_physiology0.80039849
107MP0002084_abnormal_developmental_patter0.78726368
108MP0002113_abnormal_skeleton_development0.78306843
109MP0002234_abnormal_pharynx_morphology0.77992682
110MP0003315_abnormal_perineum_morphology0.77587541
111* MP0001614_abnormal_blood_vessel0.77380628
112MP0002088_abnormal_embryonic_growth/wei0.74421885
113MP0003828_pulmonary_edema0.74257735
114MP0003984_embryonic_growth_retardation0.73404635
115MP0001672_abnormal_embryogenesis/_devel0.72353432
116MP0005171_absent_coat_pigmentation0.71161206
117MP0002697_abnormal_eye_size0.66398890
118MP0001270_distended_abdomen0.64176462
119MP0005164_abnormal_response_to0.62920733
120MP0008004_abnormal_stomach_pH0.60666021
121MP0002092_abnormal_eye_morphology0.59653459
122MP0005193_abnormal_anterior_eye0.59290746
123MP0000538_abnormal_urinary_bladder0.57603336
124MP0003795_abnormal_bone_structure0.57384116
125MP0002998_abnormal_bone_remodeling0.56601201
126MP0000003_abnormal_adipose_tissue0.55562677
127MP0001661_extended_life_span0.54742630
128MP0000467_abnormal_esophagus_morphology0.53668279
129MP0002089_abnormal_postnatal_growth/wei0.52638510
130MP0004883_abnormal_blood_vessel0.46481681
131MP0004134_abnormal_chest_morphology0.45849192
132MP0001340_abnormal_eyelid_morphology0.43555748
133MP0002177_abnormal_outer_ear0.43030565
134MP0010771_integument_phenotype0.42720481
135MP0002877_abnormal_melanocyte_morpholog0.39783392

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.63942174
2Premature rupture of membranes (HP:0001788)5.63896541
3Ankle contracture (HP:0006466)5.19445768
4Broad metatarsal (HP:0001783)5.05393855
5Aortic dissection (HP:0002647)4.66182854
6Shallow orbits (HP:0000586)4.31549817
7Bladder diverticulum (HP:0000015)3.88603923
8Aortic aneurysm (HP:0004942)3.87576715
9Soft skin (HP:0000977)3.71482041
10Cerebral aneurysm (HP:0004944)3.69858732
11Type 1 muscle fiber predominance (HP:0003803)3.65127841
12Increased connective tissue (HP:0009025)3.50637463
13Atrophic scars (HP:0001075)3.41384119
14Wrist flexion contracture (HP:0001239)3.30336310
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.15774710
16Short 4th metacarpal (HP:0010044)3.15774710
17Fragile skin (HP:0001030)3.01027767
18Renal duplication (HP:0000075)2.96911067
19Follicular hyperkeratosis (HP:0007502)2.91674785
20Spinal rigidity (HP:0003306)2.91619443
21Abnormality of dentin (HP:0010299)2.86526341
22Right ventricular cardiomyopathy (HP:0011663)2.84845781
23Abnormality of the 4th metacarpal (HP:0010012)2.83276112
24Cervical subluxation (HP:0003308)2.79367758
25Mitral valve prolapse (HP:0001634)2.78457441
26Dilatation of the ascending aorta (HP:0005111)2.75110937
27Mildly elevated creatine phosphokinase (HP:0008180)2.68251132
28Blue sclerae (HP:0000592)2.68130305
29Pulmonary artery stenosis (HP:0004415)2.61940244
30Neonatal short-limb short stature (HP:0008921)2.60902532
31Hypoventilation (HP:0002791)2.54148835
32Wormian bones (HP:0002645)2.49323423
33Flat cornea (HP:0007720)2.44008976
34Aortic valve stenosis (HP:0001650)2.43901321
35Increased variability in muscle fiber diameter (HP:0003557)2.43625238
36Mild short stature (HP:0003502)2.39951436
37Bowel diverticulosis (HP:0005222)2.37948547
38Wide anterior fontanel (HP:0000260)2.37093572
39Ventricular tachycardia (HP:0004756)2.36694599
40Rectal prolapse (HP:0002035)2.35352625
41Turricephaly (HP:0000262)2.34454804
42Vascular tortuosity (HP:0004948)2.32891030
43Selective tooth agenesis (HP:0001592)2.27590113
44Aneurysm (HP:0002617)2.27443300
45Peritonitis (HP:0002586)2.24507981
46Slender build (HP:0001533)2.23962739
47Short hallux (HP:0010109)2.22918537
48Joint laxity (HP:0001388)2.21356091
49Arterial tortuosity (HP:0005116)2.21106209
50Thin bony cortex (HP:0002753)2.20228099
51Long toe (HP:0010511)2.18974582
52Lipoatrophy (HP:0100578)2.18448297
53Natal tooth (HP:0000695)2.17934436
54Sudden death (HP:0001699)2.17307609
55Hyperextensible skin (HP:0000974)2.16326412
56Broad toe (HP:0001837)2.14087646
57Vertebral compression fractures (HP:0002953)2.13744629
58Redundant skin (HP:0001582)2.13511628
59Joint stiffness (HP:0001387)2.13030955
60Spondylolisthesis (HP:0003302)2.12964935
61Genu recurvatum (HP:0002816)2.11653770
62Abnormality of skeletal muscle fiber size (HP:0012084)2.10837338
63Ectopia lentis (HP:0001083)2.07827203
64Protruding ear (HP:0000411)2.06253680
65Renovascular hypertension (HP:0100817)2.05754941
66Mesomelia (HP:0003027)2.05193508
67Muscle fiber splitting (HP:0003555)2.04820398
68Mitral regurgitation (HP:0001653)2.04025380
69Deviation of the hallux (HP:0010051)2.04005808
70Aplasia/Hypoplasia of the hallux (HP:0008362)2.03307754
71Biconcave vertebral bodies (HP:0004586)2.02459664
72Narrow nasal bridge (HP:0000446)2.00344529
73Ulnar bowing (HP:0003031)1.99417747
74Breech presentation (HP:0001623)1.98494788
75Abnormal delivery (HP:0001787)1.97593307
76Coronal craniosynostosis (HP:0004440)1.97141829
77Mesangial abnormality (HP:0001966)1.96625161
78Nonimmune hydrops fetalis (HP:0001790)1.94344854
79Hip contracture (HP:0003273)1.93845053
80Chin dimple (HP:0010751)1.93206405
81Persistence of primary teeth (HP:0006335)1.93138058
82Premature skin wrinkling (HP:0100678)1.92421767
83Elbow flexion contracture (HP:0002987)1.92390802
84Camptodactyly of toe (HP:0001836)1.92259414
85Broad long bones (HP:0005622)1.92125820
86Atrial fibrillation (HP:0005110)1.88504037
87Thoracolumbar scoliosis (HP:0002944)1.88485325
88Absent frontal sinuses (HP:0002688)1.86370764
89Hyperacusis (HP:0010780)1.85790740
90Inguinal hernia (HP:0000023)1.84179001
91Hallux valgus (HP:0001822)1.84104034
92Abnormality of the calf musculature (HP:0001430)1.84052346
93Delayed closure of the anterior fontanelle (HP:0001476)1.82454475
94Sparse lateral eyebrow (HP:0005338)1.80810703
95Ovoid vertebral bodies (HP:0003300)1.80785445
96Aortic regurgitation (HP:0001659)1.80760748
97Osteoarthritis (HP:0002758)1.80742774
98Abnormality of skull ossification (HP:0002703)1.79798461
99Limb-girdle muscle weakness (HP:0003325)1.79377647
100Preaxial foot polydactyly (HP:0001841)1.78617626
101Limited hip movement (HP:0008800)1.77660260
102Supraventricular arrhythmia (HP:0005115)1.76324619
103Broad hallux (HP:0010055)1.75550533
104Abnormality of the acetabulum (HP:0003170)1.74740519
105Primary atrial arrhythmia (HP:0001692)1.74376019
106Emphysema (HP:0002097)1.73941122
107Wide cranial sutures (HP:0010537)1.73712373
108Arachnodactyly (HP:0001166)1.72548148
109Bicuspid aortic valve (HP:0001647)1.72372696
110Morphological abnormality of the middle ear (HP:0008609)1.71962703
111Delayed cranial suture closure (HP:0000270)1.71313960
112Infantile muscular hypotonia (HP:0008947)1.71240874
113Lymphangioma (HP:0100764)1.70716136
114Round ear (HP:0100830)1.70259814
115Broad phalanx (HP:0006009)1.69936967
116Partial duplication of the phalanx of hand (HP:0009999)1.69604797
117Deformed tarsal bones (HP:0008119)1.69266241
118Supraventricular tachycardia (HP:0004755)1.69255895
119Short nail (HP:0001799)1.68760191
120Abnormality of the fetal cardiovascular system (HP:0010948)1.68490420
121Abnormal umbilical cord blood vessels (HP:0011403)1.68490420
122Single umbilical artery (HP:0001195)1.68490420
123Osteopenia (HP:0000938)1.68187236
124Disproportionate tall stature (HP:0001519)1.68151400
125Overgrowth (HP:0001548)1.68099210
126Generalized amyotrophy (HP:0003700)1.67837145
127Hyporeflexia of lower limbs (HP:0002600)1.66884824
128Striae distensae (HP:0001065)1.66856060
129Osteolytic defects of the hand bones (HP:0009699)1.66391590
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.66391590
131Broad ribs (HP:0000885)1.65762166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.54006357
2TRIB33.33166373
3MYLK3.30676734
4EPHB23.24025292
5LATS13.10816186
6PDGFRA3.07000537
7DDR23.03048575
8LATS22.97877540
9NTRK12.32193749
10PKN22.29158883
11DMPK2.29058976
12LMTK22.26405748
13GRK52.10046029
14GRK12.04425285
15MAP3K101.83080789
16TGFBR21.75885455
17RIPK11.74268303
18PAK41.72969723
19STK38L1.72802147
20ERN11.62867957
21TGFBR11.60530178
22PAK21.58523685
23ADRBK21.53687002
24KIT1.52859970
25ADRBK11.50194840
26CDK121.50022110
27OBSCN1.49039949
28FER1.38550384
29EPHB11.38490205
30MAPKAPK31.37018477
31EEF2K1.35742815
32MET1.32860113
33PTK61.32768250
34ILK1.31382279
35NEK11.30183794
36MAPK71.29653656
37RPS6KA21.25921897
38CDC42BPA1.23059673
39STK31.22158489
40ABL21.21422199
41BMX1.19478807
42FGFR11.18157798
43MAP3K61.17908440
44TIE11.17231449
45FGFR41.16445712
46EPHA31.14884113
47TTK1.12535203
48MAP3K71.12383929
49LRRK21.11918726
50SIK11.09988220
51RPS6KB21.08668933
52PTK21.07857556
53ROCK11.07801289
54MTOR1.04067089
55EPHA20.99598436
56PIK3CG0.98612788
57MARK20.97795881
58ICK0.94801237
59DYRK1B0.94235980
60BUB10.91752682
61WEE10.89765803
62CDK70.84077523
63TESK10.84017848
64NEK20.81191035
65PAK30.77875620
66MST1R0.77844252
67SMG10.76286448
68PAK10.75840955
69PRKD30.75157044
70GRK60.74128705
71NUAK10.72917781
72KDR0.72573232
73MARK10.71335154
74PDGFRB0.70514060
75PHKG10.69165082
76PHKG20.69165082
77ERBB40.68750353
78RPS6KA40.68146677
79MAP3K80.67623594
80ROCK20.66643750
81LIMK10.66383796
82AKT20.64880319
83STK40.63504671
84MELK0.62836935
85PRKD10.62494624
86MAP3K30.58703441
87PRKCI0.57782468
88PIK3CA0.57272998
89AURKB0.56890136
90FGFR20.56421059
91GRK70.53352687
92CDC70.52141820
93TYRO30.51889396
94PTK2B0.49738331
95STK240.47452822
96DAPK30.47440339
97RPS6KL10.46995884
98RPS6KC10.46995884
99PRKD20.46858259
100MAP2K20.45935558
101ERBB20.45557747
102ACVR1B0.44626722
103CAMK2G0.44439914
104CDK40.44271930
105SRC0.43575609
106ERBB30.43308318
107FLT30.43000238
108CAMK1D0.42668601
109MKNK10.42651591
110CAMK10.42196985
111PLK10.41970700
112MAP2K10.41882457
113TRPM70.40532205
114PRKG20.40526686
115CDK60.39725235
116PLK30.39613728
117PRKCE0.39405311
118MAPKAPK20.38874186
119CDK80.37594938
120PDK40.36922502
121PDK30.36922502
122RPS6KA10.36568820
123NEK90.35204691
124PIM20.34799704
125WNK10.34530505
126CDK90.33962174
127RPS6KA60.33260286
128ZAK0.33231051
129DYRK20.32421019
130STK380.31642829
131MOS0.31313108
132MAPK10.31199026
133AKT30.31093581
134GSK3A0.31064532
135DYRK30.29477437
136JAK10.29457577
137CLK10.29207575
138MAPK40.28836920
139CDK11A0.28703152
140PRKCH0.27046345
141PAK60.25148725
142CDK150.24326976
143INSR0.23326853
144PRKCD0.23132119

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.60246333
2Basal cell carcinoma_Homo sapiens_hsa052173.31614258
3Protein digestion and absorption_Homo sapiens_hsa049742.79349357
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.76690692
5Dilated cardiomyopathy_Homo sapiens_hsa054142.67040846
6Hippo signaling pathway_Homo sapiens_hsa043902.62163748
7Focal adhesion_Homo sapiens_hsa045102.57108929
8Hedgehog signaling pathway_Homo sapiens_hsa043402.56227490
9TGF-beta signaling pathway_Homo sapiens_hsa043502.43090744
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.39935162
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.23242885
12Adherens junction_Homo sapiens_hsa045202.20114119
13Proteoglycans in cancer_Homo sapiens_hsa052052.17841865
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94648146
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.79854900
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.75622526
17Small cell lung cancer_Homo sapiens_hsa052221.73272099
18Notch signaling pathway_Homo sapiens_hsa043301.69722638
19Complement and coagulation cascades_Homo sapiens_hsa046101.66439828
20Tight junction_Homo sapiens_hsa045301.62486366
21Bladder cancer_Homo sapiens_hsa052191.60106023
22MicroRNAs in cancer_Homo sapiens_hsa052061.58940085
23Cell cycle_Homo sapiens_hsa041101.52823459
24Amoebiasis_Homo sapiens_hsa051461.52600580
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42854421
26Wnt signaling pathway_Homo sapiens_hsa043101.40766982
27Pathways in cancer_Homo sapiens_hsa052001.35935649
28Viral myocarditis_Homo sapiens_hsa054161.33323863
29Cardiac muscle contraction_Homo sapiens_hsa042601.31946894
30PI3K-Akt signaling pathway_Homo sapiens_hsa041511.30961293
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.26455214
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24073130
33Melanogenesis_Homo sapiens_hsa049161.19239144
34Lysine degradation_Homo sapiens_hsa003101.17893402
35Other glycan degradation_Homo sapiens_hsa005111.17270165
36HTLV-I infection_Homo sapiens_hsa051661.16947795
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12060330
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10674486
39Galactose metabolism_Homo sapiens_hsa000521.10560839
40Fat digestion and absorption_Homo sapiens_hsa049751.03198696
41Spliceosome_Homo sapiens_hsa030401.01682335
42DNA replication_Homo sapiens_hsa030301.01147347
43Chronic myeloid leukemia_Homo sapiens_hsa052201.00907698
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.00088378
45Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99642109
46Melanoma_Homo sapiens_hsa052180.99487097
47Renin-angiotensin system_Homo sapiens_hsa046140.98958592
48RNA transport_Homo sapiens_hsa030130.91644310
49HIF-1 signaling pathway_Homo sapiens_hsa040660.90538215
50Prion diseases_Homo sapiens_hsa050200.89585125
51p53 signaling pathway_Homo sapiens_hsa041150.88598441
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.87454108
53Colorectal cancer_Homo sapiens_hsa052100.85568086
54Carbon metabolism_Homo sapiens_hsa012000.85432541
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84388912
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.83872390
57Ribosome_Homo sapiens_hsa030100.83545725
58Malaria_Homo sapiens_hsa051440.81769337
59Mismatch repair_Homo sapiens_hsa034300.81416209
60Rap1 signaling pathway_Homo sapiens_hsa040150.80892208
61Base excision repair_Homo sapiens_hsa034100.80198287
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79713336
63Ras signaling pathway_Homo sapiens_hsa040140.77610979
64Prostate cancer_Homo sapiens_hsa052150.77127363
65Lysosome_Homo sapiens_hsa041420.76968852
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76133762
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75999826
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.75573226
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75365973
70Glutathione metabolism_Homo sapiens_hsa004800.75091185
71Axon guidance_Homo sapiens_hsa043600.73649564
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72439836
73Insulin resistance_Homo sapiens_hsa049310.71619740
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71132346
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70807546
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69756171
77N-Glycan biosynthesis_Homo sapiens_hsa005100.66525720
78Glioma_Homo sapiens_hsa052140.65002343
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64753913
80Thyroid cancer_Homo sapiens_hsa052160.63897855
81Pertussis_Homo sapiens_hsa051330.61957670
82Mineral absorption_Homo sapiens_hsa049780.61536925
83Endometrial cancer_Homo sapiens_hsa052130.61392202
84Oocyte meiosis_Homo sapiens_hsa041140.60757975
85AMPK signaling pathway_Homo sapiens_hsa041520.60721293
86Biosynthesis of amino acids_Homo sapiens_hsa012300.58477404
87mTOR signaling pathway_Homo sapiens_hsa041500.56856973
88mRNA surveillance pathway_Homo sapiens_hsa030150.56757176
89Toxoplasmosis_Homo sapiens_hsa051450.56740306
90Tyrosine metabolism_Homo sapiens_hsa003500.55487661
91GnRH signaling pathway_Homo sapiens_hsa049120.53323902
92Cocaine addiction_Homo sapiens_hsa050300.52920317
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51765223
94Viral carcinogenesis_Homo sapiens_hsa052030.51612281
95Endocytosis_Homo sapiens_hsa041440.51348091
96Insulin signaling pathway_Homo sapiens_hsa049100.50188212
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49871388
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49586157
99MAPK signaling pathway_Homo sapiens_hsa040100.49460334
100Pancreatic cancer_Homo sapiens_hsa052120.48213952
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46481525
102Renal cell carcinoma_Homo sapiens_hsa052110.46258866
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44827558
104Sulfur relay system_Homo sapiens_hsa041220.44187297
105FoxO signaling pathway_Homo sapiens_hsa040680.43385363
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.43275926
107Starch and sucrose metabolism_Homo sapiens_hsa005000.43184455
108Estrogen signaling pathway_Homo sapiens_hsa049150.42802325
109Platelet activation_Homo sapiens_hsa046110.42475180
110Calcium signaling pathway_Homo sapiens_hsa040200.42276481
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.42226609
112Vibrio cholerae infection_Homo sapiens_hsa051100.42154731
113Sulfur metabolism_Homo sapiens_hsa009200.41655959
114Thyroid hormone synthesis_Homo sapiens_hsa049180.41105571
115Choline metabolism in cancer_Homo sapiens_hsa052310.40654291
116Gap junction_Homo sapiens_hsa045400.39995807
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39685113
118Oxytocin signaling pathway_Homo sapiens_hsa049210.38604781
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36686288
120Glucagon signaling pathway_Homo sapiens_hsa049220.36267019
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36151598
122cAMP signaling pathway_Homo sapiens_hsa040240.36133578
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35900542
124Pentose phosphate pathway_Homo sapiens_hsa000300.35823740
125Sphingolipid metabolism_Homo sapiens_hsa006000.35375534
126Arginine and proline metabolism_Homo sapiens_hsa003300.34612992
127Fatty acid degradation_Homo sapiens_hsa000710.34381115
128One carbon pool by folate_Homo sapiens_hsa006700.33763671
129Arachidonic acid metabolism_Homo sapiens_hsa005900.32670510
130Ovarian steroidogenesis_Homo sapiens_hsa049130.32347501
131Phagosome_Homo sapiens_hsa041450.31533439
132PPAR signaling pathway_Homo sapiens_hsa033200.28820801
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.26823909

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