FBLL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.82360171
2vocalization behavior (GO:0071625)5.67314774
3synaptic vesicle exocytosis (GO:0016079)5.52528558
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.37832748
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.23210322
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.19246281
7neuron cell-cell adhesion (GO:0007158)5.12069965
8regulation of glutamate receptor signaling pathway (GO:1900449)5.03307713
9protein localization to synapse (GO:0035418)4.99867027
10locomotory exploration behavior (GO:0035641)4.99754466
11synaptic vesicle maturation (GO:0016188)4.95072036
12pyrimidine nucleobase catabolic process (GO:0006208)4.93530521
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.86736418
14glutamate secretion (GO:0014047)4.80286946
15regulation of synaptic vesicle exocytosis (GO:2000300)4.75078464
16neurotransmitter secretion (GO:0007269)4.46065138
17glutamate receptor signaling pathway (GO:0007215)4.46008375
18nucleobase catabolic process (GO:0046113)4.37469383
19layer formation in cerebral cortex (GO:0021819)4.36744449
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.36232838
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.33237401
22neuronal action potential propagation (GO:0019227)4.30819374
23regulation of synaptic vesicle transport (GO:1902803)4.28950649
24exploration behavior (GO:0035640)4.27532049
25synaptic transmission, glutamatergic (GO:0035249)4.25276784
26behavioral response to nicotine (GO:0035095)4.23357385
27regulation of neuronal synaptic plasticity (GO:0048168)4.20876990
28neuron-neuron synaptic transmission (GO:0007270)4.20073338
29neuron recognition (GO:0008038)4.19354199
30regulation of synapse structural plasticity (GO:0051823)4.17378696
31dendritic spine morphogenesis (GO:0060997)4.12975568
32substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.08914553
33substrate-independent telencephalic tangential migration (GO:0021826)4.08914553
34synaptic vesicle docking involved in exocytosis (GO:0016081)4.04939513
35neurotransmitter-gated ion channel clustering (GO:0072578)4.00589469
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.96427270
37establishment of mitochondrion localization (GO:0051654)3.96166845
38regulation of glutamate secretion (GO:0014048)3.93357459
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.90459997
40cell migration in hindbrain (GO:0021535)3.83608186
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.78614752
42axonal fasciculation (GO:0007413)3.78348714
43gamma-aminobutyric acid transport (GO:0015812)3.78025801
44transmission of nerve impulse (GO:0019226)3.77302759
45neurotransmitter transport (GO:0006836)3.74131750
46postsynaptic membrane organization (GO:0001941)3.68435890
47neuronal ion channel clustering (GO:0045161)3.67520785
48positive regulation of synapse maturation (GO:0090129)3.67272784
49positive regulation of synaptic transmission, GABAergic (GO:0032230)3.65824430
50regulation of postsynaptic membrane potential (GO:0060078)3.65049809
51long-term memory (GO:0007616)3.63669618
52positive regulation of membrane potential (GO:0045838)3.63326267
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.62460015
54synaptic vesicle endocytosis (GO:0048488)3.62078533
55mitochondrion transport along microtubule (GO:0047497)3.57801131
56establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.57801131
57proline transport (GO:0015824)3.55626373
58regulation of dendritic spine morphogenesis (GO:0061001)3.55040123
59response to histamine (GO:0034776)3.52097463
60prepulse inhibition (GO:0060134)3.50466869
61regulation of neurotransmitter levels (GO:0001505)3.50111847
62mechanosensory behavior (GO:0007638)3.43336456
63regulation of vesicle fusion (GO:0031338)3.41450839
64regulation of synaptic plasticity (GO:0048167)3.40385087
65presynaptic membrane assembly (GO:0097105)3.39881938
66long-term synaptic potentiation (GO:0060291)3.38405981
67behavioral response to cocaine (GO:0048148)3.35809010
68regulation of neurotransmitter secretion (GO:0046928)3.34364936
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.33699691
70membrane depolarization during action potential (GO:0086010)3.33204300
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33073831
72activation of protein kinase A activity (GO:0034199)3.32660207
73regulation of female receptivity (GO:0045924)3.30695971
74negative regulation of amino acid transport (GO:0051956)3.28656579
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26842250
76behavioral fear response (GO:0001662)3.26379792
77behavioral defense response (GO:0002209)3.26379792
78mating behavior (GO:0007617)3.25115989
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.24414427
80cerebellar granule cell differentiation (GO:0021707)3.23943757
81positive regulation of neurotransmitter transport (GO:0051590)3.23126199
82social behavior (GO:0035176)3.22538667
83intraspecies interaction between organisms (GO:0051703)3.22538667
84presynaptic membrane organization (GO:0097090)3.22460658
85adult walking behavior (GO:0007628)3.21759156
86positive regulation of neurotransmitter secretion (GO:0001956)3.19546234
87auditory behavior (GO:0031223)3.19438973
88synapse assembly (GO:0007416)3.19185659
89synaptic transmission, dopaminergic (GO:0001963)3.18215774
90neurofilament cytoskeleton organization (GO:0060052)3.17353046
91positive regulation of synapse assembly (GO:0051965)3.16646077
92positive regulation of dendritic spine development (GO:0060999)3.16512619
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.16295980
94neuromuscular process controlling posture (GO:0050884)3.15567891
95regulation of neurotransmitter transport (GO:0051588)3.14620376
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13693398
97striatum development (GO:0021756)3.12917251
98female mating behavior (GO:0060180)3.12157327
99learning (GO:0007612)3.12149598
100neuromuscular synaptic transmission (GO:0007274)3.12143379
101membrane hyperpolarization (GO:0060081)3.11394469
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10524286
103membrane depolarization (GO:0051899)3.10520308
104regulation of synaptic transmission, GABAergic (GO:0032228)3.09645525
105regulation of dendritic spine development (GO:0060998)3.08963117
106fear response (GO:0042596)3.08425676
107cellular potassium ion homeostasis (GO:0030007)3.07396097
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04999771
109positive regulation of dendritic spine morphogenesis (GO:0061003)3.04621284
110response to auditory stimulus (GO:0010996)3.03693663
111synaptic transmission (GO:0007268)3.03290278
112dendrite morphogenesis (GO:0048813)3.03137668
113central nervous system projection neuron axonogenesis (GO:0021952)3.02592933
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00964757
115startle response (GO:0001964)2.99500010
116neuromuscular process controlling balance (GO:0050885)2.99264631
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98438225
118regulation of synaptic transmission (GO:0050804)2.98191347
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96848995
120urinary tract smooth muscle contraction (GO:0014848)2.96204840
121regulation of calcium ion-dependent exocytosis (GO:0017158)2.93831881
122adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.87813332
123cerebellar Purkinje cell differentiation (GO:0021702)2.85289088
124regulation of dopamine secretion (GO:0014059)2.80122274
125axon extension (GO:0048675)2.79137432
126response to dietary excess (GO:0002021)2.79023378
127axon ensheathment in central nervous system (GO:0032291)2.76768178
128central nervous system myelination (GO:0022010)2.76768178
129axon cargo transport (GO:0008088)2.76159632
130synapse organization (GO:0050808)2.76028161
131potassium ion homeostasis (GO:0055075)2.74983472
132positive regulation of potassium ion transmembrane transport (GO:1901381)2.71974762
133cell differentiation in hindbrain (GO:0021533)2.71259643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.55118896
2GBX2_23144817_ChIP-Seq_PC3_Human3.56864281
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.27347792
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25637347
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17996148
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.84467096
7* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76257483
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.76151169
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75102759
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75102759
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.72013644
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64837574
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59680398
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57856806
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57264452
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.53453228
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48963061
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38793959
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38701363
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.37240539
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.35398105
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.31557626
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30630487
24DROSHA_22980978_ChIP-Seq_HELA_Human2.24969006
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.21432692
26TAF15_26573619_Chip-Seq_HEK293_Human2.15019863
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05635764
28* RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.02670499
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98829948
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89442208
31AR_21572438_ChIP-Seq_LNCaP_Human1.88437240
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87844240
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76734867
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72183889
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65432399
36SMAD4_21799915_ChIP-Seq_A2780_Human1.61786287
37ZNF274_21170338_ChIP-Seq_K562_Hela1.61543225
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54869543
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54712518
40* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54522419
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.51164272
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.50821437
43P300_19829295_ChIP-Seq_ESCs_Human1.48517124
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48208227
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48118008
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46013915
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41608554
48* RING1B_27294783_Chip-Seq_ESCs_Mouse1.35940945
49IGF1R_20145208_ChIP-Seq_DFB_Human1.34819800
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33497533
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32714532
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30886586
53AR_25329375_ChIP-Seq_VCAP_Human1.30323182
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.29693285
55RNF2_27304074_Chip-Seq_NSC_Mouse1.28692690
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.26899372
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.26897508
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25875553
59* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24384308
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23822430
61FUS_26573619_Chip-Seq_HEK293_Human1.21703881
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21395901
63VDR_22108803_ChIP-Seq_LS180_Human1.20633934
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.18809914
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.18721993
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14885171
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13780162
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12680208
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.11289386
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10095043
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09925856
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09689540
73STAT3_23295773_ChIP-Seq_U87_Human1.09299048
74AR_19668381_ChIP-Seq_PC3_Human1.08388586
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08318516
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07612107
77* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07213061
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.06114673
79JUN_21703547_ChIP-Seq_K562_Human1.03228617
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02164238
81TCF4_23295773_ChIP-Seq_U87_Human1.01781209
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01523037
83RUNX2_22187159_ChIP-Seq_PCA_Human1.01118591
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01048412
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99253698
86PRDM14_20953172_ChIP-Seq_ESCs_Human0.98985567
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.97853555
88YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94065148
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92806341
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92806341
91WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92671056
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92566874
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91607656
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.91452099
95AHR_22903824_ChIP-Seq_MCF-7_Human0.90153664
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89683153
97ER_23166858_ChIP-Seq_MCF-7_Human0.89049410
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88898884
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88604117
100ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87654230
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86963297
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85738062
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85548567
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83310697
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83261641
106CTCF_27219007_Chip-Seq_Bcells_Human0.83008127
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82863927
108BCAT_22108803_ChIP-Seq_LS180_Human0.81770180
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81535710
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81131700
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.81044279
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80943303
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80227469
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79864212
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79863766
116KDM2B_26808549_Chip-Seq_REH_Human0.79845453
117TP53_18474530_ChIP-ChIP_U2OS_Human0.79325158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.87503306
2MP0003880_abnormal_central_pattern5.30638938
3MP0003635_abnormal_synaptic_transmissio4.13677888
4MP0009745_abnormal_behavioral_response3.52687071
5MP0002063_abnormal_learning/memory/cond3.35575906
6MP0004270_analgesia3.35373228
7MP0001968_abnormal_touch/_nociception3.25150880
8MP0002064_seizures3.15964458
9MP0009046_muscle_twitch2.90080522
10MP0002572_abnormal_emotion/affect_behav2.88844476
11MP0002822_catalepsy2.79649373
12MP0005423_abnormal_somatic_nervous2.70648549
13MP0002272_abnormal_nervous_system2.60243680
14MP0001486_abnormal_startle_reflex2.56305186
15MP0002734_abnormal_mechanical_nocicepti2.51777100
16MP0001501_abnormal_sleep_pattern2.48855483
17MP0002736_abnormal_nociception_after2.43397557
18MP0006276_abnormal_autonomic_nervous2.43028575
19MP0001440_abnormal_grooming_behavior2.34763712
20MP0002733_abnormal_thermal_nociception2.20561724
21MP0002735_abnormal_chemical_nociception2.10544158
22MP0001529_abnormal_vocalization2.10023942
23MP0001970_abnormal_pain_threshold2.02554228
24MP0002067_abnormal_sensory_capabilities2.02089654
25MP0000778_abnormal_nervous_system1.94116921
26MP0003122_maternal_imprinting1.93306715
27MP0002184_abnormal_innervation1.91825940
28MP0001984_abnormal_olfaction1.91641835
29MP0004924_abnormal_behavior1.88666729
30MP0005386_behavior/neurological_phenoty1.88666729
31MP0002557_abnormal_social/conspecific_i1.86545715
32MP0008877_abnormal_DNA_methylation1.78734638
33MP0003329_amyloid_beta_deposits1.76152527
34MP0009780_abnormal_chondrocyte_physiolo1.75079126
35MP0001905_abnormal_dopamine_level1.73146639
36MP0003787_abnormal_imprinting1.67311718
37MP0004811_abnormal_neuron_physiology1.64517478
38MP0002909_abnormal_adrenal_gland1.63822617
39MP0003879_abnormal_hair_cell1.60480479
40MP0005645_abnormal_hypothalamus_physiol1.59475587
41MP0004142_abnormal_muscle_tone1.59092252
42MP0000955_abnormal_spinal_cord1.51760528
43MP0008569_lethality_at_weaning1.51538641
44MP0005646_abnormal_pituitary_gland1.48819792
45MP0001188_hyperpigmentation1.45523447
46MP0002066_abnormal_motor_capabilities/c1.43439359
47MP0002882_abnormal_neuron_morphology1.41633386
48MP0001502_abnormal_circadian_rhythm1.35344318
49MP0000569_abnormal_digit_pigmentation1.34837149
50MP0004885_abnormal_endolymph1.32591839
51MP0004858_abnormal_nervous_system1.28533803
52MP0000751_myopathy1.13238424
53MP0002152_abnormal_brain_morphology1.09888140
54MP0004742_abnormal_vestibular_system1.09134544
55MP0002653_abnormal_ependyma_morphology1.08614832
56MP0003633_abnormal_nervous_system1.08258414
57MP0002837_dystrophic_cardiac_calcinosis1.08112863
58MP0004133_heterotaxia1.05645192
59MP0005551_abnormal_eye_electrophysiolog1.02608559
60MP0002102_abnormal_ear_morphology0.99606932
61MP0008872_abnormal_physiological_respon0.99141254
62MP0002069_abnormal_eating/drinking_beha0.98921811
63MP0010386_abnormal_urinary_bladder0.94682176
64MP0003631_nervous_system_phenotype0.93986458
65MP0002229_neurodegeneration0.93513572
66MP0003011_delayed_dark_adaptation0.92376898
67MP0005394_taste/olfaction_phenotype0.91239386
68MP0005499_abnormal_olfactory_system0.91239386
69MP0004145_abnormal_muscle_electrophysio0.89718838
70MP0002876_abnormal_thyroid_physiology0.88982949
71MP0000631_abnormal_neuroendocrine_gland0.88348685
72MP0005535_abnormal_body_temperature0.85850827
73MP0008874_decreased_physiological_sensi0.85764543
74MP0000013_abnormal_adipose_tissue0.85564165
75MP0003121_genomic_imprinting0.85134852
76MP0001963_abnormal_hearing_physiology0.84731535
77MP0005253_abnormal_eye_physiology0.83761338
78MP0002752_abnormal_somatic_nervous0.83400845
79MP0004085_abnormal_heartbeat0.77704091
80MP0002638_abnormal_pupillary_reflex0.77190069
81MP0001177_atelectasis0.76957692
82MP0000604_amyloidosis0.76135674
83MP0005409_darkened_coat_color0.74715320
84MP0008961_abnormal_basal_metabolism0.74647289
85MP0002751_abnormal_autonomic_nervous0.74381097
86MP0003123_paternal_imprinting0.73555276
87MP0001944_abnormal_pancreas_morphology0.72371167
88MP0003634_abnormal_glial_cell0.71877953
89MP0002090_abnormal_vision0.70470475
90MP0003137_abnormal_impulse_conducting0.68989309
91MP0005195_abnormal_posterior_eye0.68865449
92MP0003890_abnormal_embryonic-extraembry0.68627098
93MP0001986_abnormal_taste_sensitivity0.65113504
94MP0001664_abnormal_digestion0.64892371
95MP0003632_abnormal_nervous_system0.64666078
96MP0003119_abnormal_digestive_system0.64470349
97MP0006072_abnormal_retinal_apoptosis0.63370829
98MP0006292_abnormal_olfactory_placode0.61706934
99MP0000639_abnormal_adrenal_gland0.60089041
100MP0003283_abnormal_digestive_organ0.59899592
101MP0001485_abnormal_pinna_reflex0.59879243
102MP0005623_abnormal_meninges_morphology0.59227086
103MP0000920_abnormal_myelination0.58937720
104MP0004233_abnormal_muscle_weight0.58607151
105MP0003075_altered_response_to0.58274100
106MP0009379_abnormal_foot_pigmentation0.57905525
107MP0002082_postnatal_lethality0.57249582
108MP0000026_abnormal_inner_ear0.57165768
109MP0004484_altered_response_of0.56263023
110MP0001943_abnormal_respiration0.56192607
111MP0003861_abnormal_nervous_system0.56111749
112MP0003942_abnormal_urinary_system0.55972792
113MP0000579_abnormal_nail_morphology0.54706704
114MP0005187_abnormal_penis_morphology0.51523464
115MP0003690_abnormal_glial_cell0.50849736
116MP0003956_abnormal_body_size0.49873387
117MP0010769_abnormal_survival0.49186673
118MP0010770_preweaning_lethality0.49134058

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.27048533
2Myokymia (HP:0002411)6.57715170
3Visual hallucinations (HP:0002367)6.06345593
4Focal seizures (HP:0007359)5.91453098
5Atonic seizures (HP:0010819)4.91527519
6Absence seizures (HP:0002121)4.80080199
7Epileptic encephalopathy (HP:0200134)4.57237445
8Dialeptic seizures (HP:0011146)4.33101354
9Febrile seizures (HP:0002373)4.28000937
10Generalized tonic-clonic seizures (HP:0002069)4.04923170
11Progressive cerebellar ataxia (HP:0002073)3.94688837
12Hyperventilation (HP:0002883)3.69645290
13Broad-based gait (HP:0002136)3.59699199
14Supranuclear gaze palsy (HP:0000605)3.38950181
15Limb dystonia (HP:0002451)3.36170560
16Abnormal eating behavior (HP:0100738)3.25690828
17Polyphagia (HP:0002591)3.23076378
18Action tremor (HP:0002345)3.20173218
19Amblyopia (HP:0000646)3.19084753
20Mutism (HP:0002300)3.18658972
21Cerebral inclusion bodies (HP:0100314)3.15013598
22Anxiety (HP:0000739)3.10703727
23Poor eye contact (HP:0000817)3.09851040
24Progressive inability to walk (HP:0002505)2.98762202
25Impaired vibration sensation in the lower limbs (HP:0002166)2.93444952
26Depression (HP:0000716)2.93092045
27Neurofibrillary tangles (HP:0002185)2.87219366
28Dysdiadochokinesis (HP:0002075)2.85855794
29Dysmetria (HP:0001310)2.85151659
30Truncal ataxia (HP:0002078)2.83549703
31Drooling (HP:0002307)2.81344347
32Excessive salivation (HP:0003781)2.81344347
33Impaired social interactions (HP:0000735)2.79768130
34Abnormal social behavior (HP:0012433)2.79768130
35Gaze-evoked nystagmus (HP:0000640)2.79533118
36Ankle clonus (HP:0011448)2.76211617
37Urinary bladder sphincter dysfunction (HP:0002839)2.61814891
38Failure to thrive in infancy (HP:0001531)2.60872383
39Epileptiform EEG discharges (HP:0011182)2.59325137
40EEG with generalized epileptiform discharges (HP:0011198)2.50811743
41Hemiparesis (HP:0001269)2.45227037
42Torticollis (HP:0000473)2.44777716
43Inability to walk (HP:0002540)2.43179764
44Lissencephaly (HP:0001339)2.41916520
45Generalized myoclonic seizures (HP:0002123)2.39460549
46Scanning speech (HP:0002168)2.39042109
47Akinesia (HP:0002304)2.36340308
48Hypsarrhythmia (HP:0002521)2.36079393
49Fetal akinesia sequence (HP:0001989)2.36034707
50Postural instability (HP:0002172)2.35745489
51Bradykinesia (HP:0002067)2.33879992
52Spastic tetraplegia (HP:0002510)2.33603097
53Pheochromocytoma (HP:0002666)2.32248101
54Termporal pattern (HP:0011008)2.32056913
55Insidious onset (HP:0003587)2.32056913
56Genetic anticipation (HP:0003743)2.31108359
57Focal dystonia (HP:0004373)2.30754992
58Poor suck (HP:0002033)2.30664196
59Papilledema (HP:0001085)2.29907930
60Urinary urgency (HP:0000012)2.29209219
61Diplopia (HP:0000651)2.28079627
62Abnormality of binocular vision (HP:0011514)2.28079627
63Spastic gait (HP:0002064)2.27126460
64Psychosis (HP:0000709)2.26114327
65Absent speech (HP:0001344)2.25213461
66Amyotrophic lateral sclerosis (HP:0007354)2.24587038
67Medial flaring of the eyebrow (HP:0010747)2.24252325
68Abnormal hair whorl (HP:0010721)2.23833472
69Impaired smooth pursuit (HP:0007772)2.20863075
70Molar tooth sign on MRI (HP:0002419)2.19893310
71Abnormality of midbrain morphology (HP:0002418)2.19893310
72Delusions (HP:0000746)2.18243192
73Hypoventilation (HP:0002791)2.14786032
74Sleep apnea (HP:0010535)2.14683947
75Retinal dysplasia (HP:0007973)2.14558310
76Morphological abnormality of the pyramidal tract (HP:0002062)2.14083481
77Abnormality of the corticospinal tract (HP:0002492)2.13623137
78Pachygyria (HP:0001302)2.13404000
79Status epilepticus (HP:0002133)2.13138544
80Craniofacial dystonia (HP:0012179)2.11475822
81Gait imbalance (HP:0002141)2.10829005
82Nephronophthisis (HP:0000090)2.10495299
83Prolonged QT interval (HP:0001657)2.10396365
84Muscular hypotonia of the trunk (HP:0008936)2.10021111
85Abnormality of the lower motor neuron (HP:0002366)2.09616567
86Intention tremor (HP:0002080)2.03716777
87Stereotypic behavior (HP:0000733)2.03262591
88Hyperthyroidism (HP:0000836)2.01522302
89Esotropia (HP:0000565)2.00833868
90Congenital primary aphakia (HP:0007707)2.00388453
91Congenital stationary night blindness (HP:0007642)1.97299038
92Neuroendocrine neoplasm (HP:0100634)1.96876736
93Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94910170
94Hypoplasia of the brainstem (HP:0002365)1.94910170
95Abnormality of ocular smooth pursuit (HP:0000617)1.94465299
96Type II lissencephaly (HP:0007260)1.94356597
97Specific learning disability (HP:0001328)1.93897155
98Rapidly progressive (HP:0003678)1.93557235
99Protruding tongue (HP:0010808)1.92534980
100Incomplete penetrance (HP:0003829)1.90807796
101Lower limb muscle weakness (HP:0007340)1.90345350
102Nephrogenic diabetes insipidus (HP:0009806)1.89950960
103Agitation (HP:0000713)1.88241977
104Blue irides (HP:0000635)1.87818101
105Generalized hypotonia (HP:0001290)1.87524439
106Abnormality of salivation (HP:0100755)1.87068730
107Vaginal atresia (HP:0000148)1.85404720
108Neuronal loss in central nervous system (HP:0002529)1.85150141
109Progressive macrocephaly (HP:0004481)1.84890921
110Genital tract atresia (HP:0001827)1.83072202
111Hemiplegia (HP:0002301)1.82552689
112Inappropriate behavior (HP:0000719)1.82435046
113Abnormality of the labia minora (HP:0012880)1.82197072
114Impaired vibratory sensation (HP:0002495)1.81698749
115Abnormal EKG (HP:0003115)1.81115565
116Intellectual disability, severe (HP:0010864)1.81019221
117Abnormal mitochondria in muscle tissue (HP:0008316)1.80962386
118Megalencephaly (HP:0001355)1.80730211
119Hepatoblastoma (HP:0002884)1.79142750
120Oligomenorrhea (HP:0000876)1.78860619
121Double outlet right ventricle (HP:0001719)1.78546469
122Congenital malformation of the right heart (HP:0011723)1.78546469
123True hermaphroditism (HP:0010459)1.78308035
124Acute necrotizing encephalopathy (HP:0006965)1.76481430
125Pancreatic fibrosis (HP:0100732)1.75176429
126Spastic tetraparesis (HP:0001285)1.72971073
127Exotropia (HP:0000577)1.70296260
128Restlessness (HP:0000711)1.70112203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.33270419
2EPHA44.26978984
3MAP3K93.93703060
4MARK13.52149813
5MAP3K122.97237584
6MAP3K42.95492066
7MINK12.75018794
8MAP2K72.46845216
9CASK2.42096674
10NTRK22.26684537
11DYRK22.22902135
12DAPK22.19418746
13PNCK2.01718909
14RIPK41.89412853
15MAP2K41.87421829
16PAK61.86948275
17KSR21.78142373
18ARAF1.77719393
19PRPF4B1.75835789
20SIK21.71561580
21GRK51.69871249
22KSR11.69863611
23NME11.69119609
24PLK21.67604919
25TNIK1.59864096
26CDK51.53123428
27DAPK11.52258871
28MAPK131.51480114
29NTRK11.48073002
30CAMKK11.36496206
31CDK191.34834925
32FES1.28440406
33PRKCG1.26596923
34MAP3K131.20464674
35UHMK11.18834040
36CAMK2A1.16582830
37PRKD31.16185614
38LATS21.06468523
39PHKG21.04391098
40PHKG11.04391098
41FRK1.03598320
42CDK180.97911640
43CDK140.97730516
44TYRO30.96009096
45CDK150.95206709
46STK380.93417925
47CAMK2B0.91097717
48WNK40.87753429
49CAMKK20.87613522
50CSNK1G20.87395799
51GRK10.84534961
52CDK11A0.84098324
53BMPR20.83330312
54DYRK1A0.81158296
55STK110.79257573
56OXSR10.78310288
57PTK2B0.75240288
58CAMK10.74791588
59CSNK1G10.74583542
60RAF10.74430524
61FGR0.73783659
62TAOK10.72381152
63PAK30.69568871
64CAMK1D0.69335159
65MAP3K20.66645120
66GRK70.65776903
67TRIM280.65700041
68FGFR20.64512959
69SGK2230.64189372
70SGK4940.64189372
71WNK30.63034817
72LIMK10.60421635
73CSNK1E0.60048912
74ALK0.59354258
75TNK20.58498669
76SGK10.58423015
77BMPR1B0.58291551
78MARK20.57969306
79STK160.57571936
80PRKCZ0.56496393
81PRKCH0.55305678
82CAMK2D0.55064207
83CAMK2G0.53824921
84SGK30.53480067
85ZAK0.53033887
86TAF10.52594917
87PRKCE0.51777738
88CAMK1G0.51108472
89PRKCI0.50215311
90CSNK1A1L0.49906007
91DYRK1B0.49747082
92CSNK1G30.48391545
93LMTK20.48098052
94RET0.47731866
95ADRBK20.47673498
96PRKAA10.46974650
97BRAF0.46239450
98MAP3K10.44904653
99ADRBK10.44742417
100PINK10.44094655
101GRK60.43995009
102BCR0.43955000
103SIK30.43902372
104ICK0.43797246
105DAPK30.43122842
106FER0.42509906
107BRSK10.42298572
108SGK20.41320004
109PDK10.39932053
110PDPK10.39764532
111PRKG10.39444632
112FYN0.39374618
113RPS6KA30.38924867
114MAPK120.38833961
115STK390.37887375
116CAMK40.37460953
117PKN10.37399922
118EPHB20.37264264
119INSRR0.36626328
120ROCK20.36056176
121CCNB10.36038461
122MAPK100.35841692
123SCYL20.35447629
124CSNK1A10.34687193
125MAP3K60.34121269
126CSNK1D0.33194452
127PRKACA0.32565690
128MAPK80.32459302
129PRKCA0.32279174
130MUSK0.31176970
131MAP2K10.30973977
132RPS6KA20.30901720
133PRKDC0.29972587
134MAP4K20.28471972

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.20057832
2Synaptic vesicle cycle_Homo sapiens_hsa047213.58280299
3GABAergic synapse_Homo sapiens_hsa047272.89367347
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80247208
5Olfactory transduction_Homo sapiens_hsa047402.69273917
6Morphine addiction_Homo sapiens_hsa050322.64851588
7Long-term potentiation_Homo sapiens_hsa047202.63627202
8Circadian entrainment_Homo sapiens_hsa047132.60559405
9Amphetamine addiction_Homo sapiens_hsa050312.56897973
10Glutamatergic synapse_Homo sapiens_hsa047242.54966063
11Dopaminergic synapse_Homo sapiens_hsa047282.27001860
12Collecting duct acid secretion_Homo sapiens_hsa049662.09784658
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08689293
14Salivary secretion_Homo sapiens_hsa049702.01757486
15Cocaine addiction_Homo sapiens_hsa050301.99525273
16Taste transduction_Homo sapiens_hsa047421.98023993
17Serotonergic synapse_Homo sapiens_hsa047261.88113837
18Cholinergic synapse_Homo sapiens_hsa047251.87667193
19Insulin secretion_Homo sapiens_hsa049111.80073066
20Renin secretion_Homo sapiens_hsa049241.76497950
21Gastric acid secretion_Homo sapiens_hsa049711.69522459
22Long-term depression_Homo sapiens_hsa047301.69406496
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68492828
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64606785
25Oxidative phosphorylation_Homo sapiens_hsa001901.59314601
26Oxytocin signaling pathway_Homo sapiens_hsa049211.59077437
27Calcium signaling pathway_Homo sapiens_hsa040201.57328463
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51234649
29Cardiac muscle contraction_Homo sapiens_hsa042601.46536506
30Gap junction_Homo sapiens_hsa045401.39311314
31GnRH signaling pathway_Homo sapiens_hsa049121.38864807
32Parkinsons disease_Homo sapiens_hsa050121.37016840
33Alzheimers disease_Homo sapiens_hsa050101.34235095
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31027428
35Vibrio cholerae infection_Homo sapiens_hsa051101.28127785
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27219669
37Axon guidance_Homo sapiens_hsa043601.19040504
38cAMP signaling pathway_Homo sapiens_hsa040241.14010877
39Vitamin B6 metabolism_Homo sapiens_hsa007501.10758152
40Estrogen signaling pathway_Homo sapiens_hsa049151.09616014
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07823952
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.05430424
43Melanogenesis_Homo sapiens_hsa049161.05157806
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01038551
45Phototransduction_Homo sapiens_hsa047440.99904369
46Glioma_Homo sapiens_hsa052140.97152163
47Steroid biosynthesis_Homo sapiens_hsa001000.96520604
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93663624
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92645598
50ErbB signaling pathway_Homo sapiens_hsa040120.90526461
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90345581
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87668893
53Huntingtons disease_Homo sapiens_hsa050160.87060882
54Oocyte meiosis_Homo sapiens_hsa041140.86299754
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.83797519
56Type II diabetes mellitus_Homo sapiens_hsa049300.82510731
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81485864
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79245689
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.71459926
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68125865
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67210520
62Alcoholism_Homo sapiens_hsa050340.65707150
63Pancreatic secretion_Homo sapiens_hsa049720.64272497
64Type I diabetes mellitus_Homo sapiens_hsa049400.63355807
65MAPK signaling pathway_Homo sapiens_hsa040100.63227880
66Dilated cardiomyopathy_Homo sapiens_hsa054140.63194444
67Folate biosynthesis_Homo sapiens_hsa007900.61994583
68Thyroid hormone synthesis_Homo sapiens_hsa049180.61925064
69Protein export_Homo sapiens_hsa030600.61301245
70Dorso-ventral axis formation_Homo sapiens_hsa043200.60751502
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60675786
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60386143
73Choline metabolism in cancer_Homo sapiens_hsa052310.59404779
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59020261
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54192750
76VEGF signaling pathway_Homo sapiens_hsa043700.51760556
77Ras signaling pathway_Homo sapiens_hsa040140.50008941
78Prion diseases_Homo sapiens_hsa050200.49758504
79Hedgehog signaling pathway_Homo sapiens_hsa043400.49572405
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49183064
81Glucagon signaling pathway_Homo sapiens_hsa049220.49015295
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.48278323
83Hippo signaling pathway_Homo sapiens_hsa043900.46941348
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44355291
85Tryptophan metabolism_Homo sapiens_hsa003800.41933193
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.41321868
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41014293
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40923550
89Wnt signaling pathway_Homo sapiens_hsa043100.40520870
90Regulation of autophagy_Homo sapiens_hsa041400.40221299
91Rap1 signaling pathway_Homo sapiens_hsa040150.39482202
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39401989
93Rheumatoid arthritis_Homo sapiens_hsa053230.38775131
94Inositol phosphate metabolism_Homo sapiens_hsa005620.38338587
95Arginine and proline metabolism_Homo sapiens_hsa003300.36702840
96beta-Alanine metabolism_Homo sapiens_hsa004100.36105891
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35134588
98Ether lipid metabolism_Homo sapiens_hsa005650.34372778
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34108386
100Renal cell carcinoma_Homo sapiens_hsa052110.33940988
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32341763
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31587148
103African trypanosomiasis_Homo sapiens_hsa051430.31547572
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31250724
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30966941
106AMPK signaling pathway_Homo sapiens_hsa041520.30571415
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29286854
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29252894
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29069827
110Endometrial cancer_Homo sapiens_hsa052130.28806508
111Tight junction_Homo sapiens_hsa045300.28727718
112Butanoate metabolism_Homo sapiens_hsa006500.28468444
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28416571
114Endocytosis_Homo sapiens_hsa041440.26958215
115Insulin signaling pathway_Homo sapiens_hsa049100.26542828
116Ovarian steroidogenesis_Homo sapiens_hsa049130.26499887
117Bile secretion_Homo sapiens_hsa049760.26355679
118Basal cell carcinoma_Homo sapiens_hsa052170.26253368
119Non-small cell lung cancer_Homo sapiens_hsa052230.25730301
120Phagosome_Homo sapiens_hsa041450.24342496
121mTOR signaling pathway_Homo sapiens_hsa041500.21861114
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21480455

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