FAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar granule cell differentiation (GO:0021707)9.41835335
2desmosome organization (GO:0002934)8.47451364
3response to pheromone (GO:0019236)7.35455002
4cerebellar Purkinje cell differentiation (GO:0021702)7.05023654
5sodium ion export (GO:0071436)6.98532682
6cellular potassium ion homeostasis (GO:0030007)6.87800336
7G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.66731420
8neuronal action potential propagation (GO:0019227)6.54663125
9establishment of skin barrier (GO:0061436)6.45346585
10cell differentiation in hindbrain (GO:0021533)6.45248634
11locomotory exploration behavior (GO:0035641)6.32951083
12gamma-aminobutyric acid transport (GO:0015812)6.16376232
13ionotropic glutamate receptor signaling pathway (GO:0035235)5.80903286
14glutamate receptor signaling pathway (GO:0007215)5.78850872
15regulation of water loss via skin (GO:0033561)5.74448825
16positive regulation of synapse maturation (GO:0090129)5.65311419
17bundle of His cell to Purkinje myocyte communication (GO:0086069)5.62505851
18keratinocyte proliferation (GO:0043616)5.54097532
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.35333531
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.32077792
21keratinization (GO:0031424)5.24410977
22synaptic transmission, glutamatergic (GO:0035249)5.23766226
23regulation of short-term neuronal synaptic plasticity (GO:0048172)5.22979236
24positive regulation of potassium ion transmembrane transporter activity (GO:1901018)5.19516221
25intermediate filament organization (GO:0045109)4.96463073
26cell-substrate junction assembly (GO:0007044)4.93423109
27neuromuscular process controlling posture (GO:0050884)4.85855036
28negative regulation of hormone biosynthetic process (GO:0032353)4.79749372
29negative regulation of hormone metabolic process (GO:0032351)4.79749372
30potassium ion import (GO:0010107)4.78519486
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.78364511
32vocalization behavior (GO:0071625)4.78287077
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78182280
34neurotransmitter secretion (GO:0007269)4.76439602
35long-term memory (GO:0007616)4.67049238
36synaptic vesicle maturation (GO:0016188)4.63310330
37cell communication by electrical coupling (GO:0010644)4.59182676
38establishment of nucleus localization (GO:0040023)4.43091086
39gamma-aminobutyric acid signaling pathway (GO:0007214)4.36742433
40cellular sodium ion homeostasis (GO:0006883)4.33069239
41neuron-neuron synaptic transmission (GO:0007270)4.32920824
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.28674476
43regulation of synapse maturation (GO:0090128)4.22649000
44potassium ion homeostasis (GO:0055075)4.19284498
45membrane depolarization during action potential (GO:0086010)4.11860874
46musculoskeletal movement (GO:0050881)4.07382457
47multicellular organismal movement (GO:0050879)4.07382457
48membrane hyperpolarization (GO:0060081)3.99013933
49multicellular organismal water homeostasis (GO:0050891)3.96815487
50positive regulation of potassium ion transmembrane transport (GO:1901381)3.96131249
51synaptic vesicle exocytosis (GO:0016079)3.93511833
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.93424387
53regulation of synaptic vesicle transport (GO:1902803)3.92038977
54negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.91800081
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.90428225
56neuromuscular process controlling balance (GO:0050885)3.90205476
57peptidyl-tyrosine autophosphorylation (GO:0038083)3.85098207
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.85086744
59adult walking behavior (GO:0007628)3.82407415
60layer formation in cerebral cortex (GO:0021819)3.81098751
61neurotransmitter-gated ion channel clustering (GO:0072578)3.76374108
62C4-dicarboxylate transport (GO:0015740)3.76197412
63cell communication involved in cardiac conduction (GO:0086065)3.74715527
64exploration behavior (GO:0035640)3.73934636
65regulation of postsynaptic membrane potential (GO:0060078)3.73892601
66amino acid import (GO:0043090)3.71784506
67regulation of beta-amyloid formation (GO:1902003)3.70406740
68regulation of heart rate by cardiac conduction (GO:0086091)3.69054866
69glutamate secretion (GO:0014047)3.67042249
70epidermis development (GO:0008544)3.64136337
71positive regulation of membrane potential (GO:0045838)3.61566451
72transmission of nerve impulse (GO:0019226)3.61391170
73negative regulation of keratinocyte proliferation (GO:0010839)3.61212199
74epithelial cell differentiation involved in prostate gland development (GO:0060742)3.59811019
75neurotransmitter transport (GO:0006836)3.59056087
76dendrite morphogenesis (GO:0048813)3.53713942
77membrane depolarization (GO:0051899)3.49693965
78regulation of long-term neuronal synaptic plasticity (GO:0048169)3.49681432
79glycine transport (GO:0015816)3.48509450
80cardiac conduction (GO:0061337)3.47840758
81keratinocyte differentiation (GO:0030216)3.46727438
82regulation of neurotransmitter levels (GO:0001505)3.45301058
83long-chain fatty acid biosynthetic process (GO:0042759)3.43836500
84heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)3.41399405
85neuronal ion channel clustering (GO:0045161)3.37791075
86hair cycle (GO:0042633)3.37565423
87molting cycle (GO:0042303)3.37565423
88negative regulation of protein localization to cell surface (GO:2000009)3.37041700
89regulation of synaptic vesicle exocytosis (GO:2000300)3.34174683
90surfactant homeostasis (GO:0043129)3.29905307
91membrane repolarization (GO:0086009)3.26457776
92chemosensory behavior (GO:0007635)3.23744490
93prepulse inhibition (GO:0060134)3.23069043
94water homeostasis (GO:0030104)3.22606629
95regulation of synaptic transmission, glutamatergic (GO:0051966)3.19826932
96regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.18516332
97regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.18371420
98intermediate filament cytoskeleton organization (GO:0045104)3.18207425
99cytoskeletal anchoring at plasma membrane (GO:0007016)3.17975252
100positive regulation of potassium ion transport (GO:0043268)3.17359421
101establishment of planar polarity (GO:0001736)3.15394888
102establishment of tissue polarity (GO:0007164)3.15394888
103detection of temperature stimulus (GO:0016048)3.12474021
104regulation of glutamate receptor signaling pathway (GO:1900449)3.11574541
105positive regulation of sodium ion transmembrane transport (GO:1902307)3.11082154
106relaxation of cardiac muscle (GO:0055119)3.07916067
107cochlea development (GO:0090102)3.07837578
108neuromuscular process (GO:0050905)3.06904683
109intermediate filament-based process (GO:0045103)3.04802119
110dendritic spine morphogenesis (GO:0060997)3.04534893
111regulation of vesicle fusion (GO:0031338)3.04156440
112regulation of amyloid precursor protein catabolic process (GO:1902991)3.04110535
113regulation of voltage-gated calcium channel activity (GO:1901385)3.01934152
114L-amino acid import (GO:0043092)3.01081544
115positive regulation of synapse assembly (GO:0051965)3.00992459
116regulation of ARF protein signal transduction (GO:0032012)2.99389674
117peptide cross-linking (GO:0018149)2.95999761
118central nervous system myelination (GO:0022010)2.95982949
119axon ensheathment in central nervous system (GO:0032291)2.95982949
120synaptic vesicle docking involved in exocytosis (GO:0016081)2.95185599
121mechanosensory behavior (GO:0007638)2.94161865
122proline transport (GO:0015824)2.94023374
123acidic amino acid transport (GO:0015800)2.93781315
124synaptic vesicle endocytosis (GO:0048488)2.93129082
125negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92823261
126suckling behavior (GO:0001967)2.92162481
127regulation of keratinocyte proliferation (GO:0010837)2.92032984
128detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.91887441
129detection of temperature stimulus involved in sensory perception (GO:0050961)2.91887441
130regulation of synaptic plasticity (GO:0048167)2.91817162
131regulation of neurotransmitter secretion (GO:0046928)2.91503311
132synapse assembly (GO:0007416)2.91165010
133protein targeting to plasma membrane (GO:0072661)2.90909625
134auditory behavior (GO:0031223)2.90686678
135regulation of neuronal synaptic plasticity (GO:0048168)2.90144915
136negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86813623
137negative regulation of inclusion body assembly (GO:0090084)2.86228792
138polarized epithelial cell differentiation (GO:0030859)2.85846129
139lateral sprouting from an epithelium (GO:0060601)2.83533929
140chemical homeostasis within a tissue (GO:0048875)2.78376320
141regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78276130
142mating behavior (GO:0007617)2.77160894
143protein localization to endosome (GO:0036010)2.75453220
144filopodium assembly (GO:0046847)2.72539793
145neurotransmitter uptake (GO:0001504)2.71382870
146cardiac muscle cell action potential involved in contraction (GO:0086002)2.69097884
147apical protein localization (GO:0045176)2.68608520
148positive regulation of vesicle fusion (GO:0031340)2.65228046
149hemidesmosome assembly (GO:0031581)11.8187111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.56029620
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.33746119
3DROSHA_22980978_ChIP-Seq_HELA_Human3.16087171
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78543265
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78543265
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76922710
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67270374
8GBX2_23144817_ChIP-Seq_PC3_Human2.64690610
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.60873313
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.60435839
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.58458588
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52759058
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52245275
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39337904
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39315301
16REST_21632747_ChIP-Seq_MESCs_Mouse2.38911313
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36142418
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31823181
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.30810860
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26992720
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26809145
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.26548072
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19493076
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.14844711
25* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.08329337
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08114038
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.06138544
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.97731152
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.95054521
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88030201
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.87673954
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.81789792
33TP53_16413492_ChIP-PET_HCT116_Human1.78270061
34* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.76865947
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64021478
36ZNF274_21170338_ChIP-Seq_K562_Hela1.62154548
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61807084
38KDM2B_26808549_Chip-Seq_K562_Human1.55631121
39ZNF263_19887448_ChIP-Seq_K562_Human1.49922143
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47406122
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44383219
42* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44179210
43* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44179210
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.43659840
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43333535
46* TP63_22573176_ChIP-Seq_HFKS_Human1.42854599
47LXR_22292898_ChIP-Seq_THP-1_Human1.42742226
48* AR_19668381_ChIP-Seq_PC3_Human1.42196490
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36937857
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36273026
51AR_21572438_ChIP-Seq_LNCaP_Human1.35704247
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30790902
53* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30112525
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24384458
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23318658
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23275265
57CTCF_27219007_Chip-Seq_Bcells_Human1.21565974
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20891956
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20843339
60STAT3_23295773_ChIP-Seq_U87_Human1.20472984
61* TP63_23658742_ChIP-Seq_EP156T_Human1.20265638
62GATA1_22025678_ChIP-Seq_K562_Human1.19804287
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19351775
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19337995
65RXR_22108803_ChIP-Seq_LS180_Human1.17026770
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.14764055
67SMC4_20622854_ChIP-Seq_HELA_Human1.14684925
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.12843414
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.12407000
70AR_25329375_ChIP-Seq_VCAP_Human1.11587173
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11359932
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11112598
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10465870
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08275281
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07963719
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07944667
77* AHR_22903824_ChIP-Seq_MCF-7_Human1.07832742
78* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07534575
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.05583137
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04434630
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04402490
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04243126
83SMAD3_21741376_ChIP-Seq_ESCs_Human1.03773341
84TCF4_23295773_ChIP-Seq_U87_Human1.03756391
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03140671
86RACK7_27058665_Chip-Seq_MCF-7_Human1.02964130
87TET1_21490601_ChIP-Seq_MESCs_Mouse1.02870144
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.02446867
89TP63_17297297_ChIP-ChIP_HaCaT_Human1.02303353
90KLF5_25053715_ChIP-Seq_YYC3_Human1.02182584
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01256002
92SMAD4_21741376_ChIP-Seq_HESCs_Human1.00646408
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00557097
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99589470
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98821013
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98803091
97TRIM28_21343339_ChIP-Seq_HEK293_Human0.98523958
98NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98281647
99KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98124710
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98113088
101EGR1_19032775_ChIP-ChIP_M12_Human0.97938072
102RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96822527
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95929266
104TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95829253
105TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95593837
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95373675
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95236931
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95165151
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95165151
110SMAD_19615063_ChIP-ChIP_OVARY_Human0.94632554
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94461273
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94150160
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.93927748
114SMAD4_21741376_ChIP-Seq_EPCs_Human0.93892445
115ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93423255
116KDM2B_26808549_Chip-Seq_JURKAT_Human0.93371874
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92941198
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92883853
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.92735696
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92420185
121* TP53_23651856_ChIP-Seq_MEFs_Mouse0.91513772
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90763252
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.90353691
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.90282312
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90065111
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.89553166
127* UBF1/2_26484160_Chip-Seq_HMECs_Human0.89098459
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88701281
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86628700
130CREB1_26743006_Chip-Seq_LNCaP_Human0.86433276
131* TP53_18474530_ChIP-ChIP_U2OS_Human0.86330534
132FOXA2_19822575_ChIP-Seq_HepG2_Human0.86285570
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85335906
134KDM2B_26808549_Chip-Seq_DND41_Human0.83933628
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82154544
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.80973705
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80947320
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78970806
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77599131
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.77563269
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.77524316
142P68_20966046_ChIP-Seq_HELA_Human0.75787225
143SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75382372
144* TBX20_22328084_ChIP-Seq_HEART_Mouse0.75379380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009046_muscle_twitch6.01693012
2MP0004859_abnormal_synaptic_plasticity5.43361726
3MP0008569_lethality_at_weaning4.27243097
4MP0010234_abnormal_vibrissa_follicle4.08038942
5MP0003635_abnormal_synaptic_transmissio3.95632096
6MP0004145_abnormal_muscle_electrophysio3.69124734
7MP0002272_abnormal_nervous_system3.25602888
8MP0000566_synostosis3.18434307
9MP0009745_abnormal_behavioral_response3.08495317
10MP0002064_seizures3.08101199
11MP0004270_analgesia2.97738786
12MP0005275_abnormal_skin_tensile2.92234098
13MP0005423_abnormal_somatic_nervous2.90629842
14MP0002734_abnormal_mechanical_nocicepti2.86849337
15MP0005409_darkened_coat_color2.75871255
16MP0002067_abnormal_sensory_capabilities2.73532099
17MP0002184_abnormal_innervation2.69225523
18MP0002572_abnormal_emotion/affect_behav2.57221682
19MP0000467_abnormal_esophagus_morphology2.55604193
20MP0001968_abnormal_touch/_nociception2.54067003
21MP0002063_abnormal_learning/memory/cond2.53249740
22MP0001440_abnormal_grooming_behavior2.43079960
23MP0004147_increased_porphyrin_level2.38798471
24MP0010678_abnormal_skin_adnexa2.37886482
25MP0003453_abnormal_keratinocyte_physiol2.36999772
26MP0004381_abnormal_hair_follicle2.32935790
27MP0000762_abnormal_tongue_morphology2.31824915
28MP0002735_abnormal_chemical_nociception2.29782303
29MP0003941_abnormal_skin_development2.26611041
30MP0002060_abnormal_skin_morphology2.21455076
31MP0002736_abnormal_nociception_after2.18951572
32MP0002098_abnormal_vibrissa_morphology2.17265626
33MP0000383_abnormal_hair_follicle2.15536384
34MP0005501_abnormal_skin_physiology2.15309297
35MP0003632_abnormal_nervous_system2.09877718
36MP0001486_abnormal_startle_reflex2.09277456
37MP0001216_abnormal_epidermal_layer2.08892989
38MP0001849_ear_inflammation2.08467089
39MP0001501_abnormal_sleep_pattern2.03008552
40MP0003329_amyloid_beta_deposits1.96734972
41MP0004142_abnormal_muscle_tone1.91925914
42MP0003566_abnormal_cell_adhesion1.88890645
43MP0004885_abnormal_endolymph1.86501283
44MP0010771_integument_phenotype1.82586419
45MP0000579_abnormal_nail_morphology1.80524407
46MP0002733_abnormal_thermal_nociception1.78242202
47MP0004858_abnormal_nervous_system1.73808035
48MP0004742_abnormal_vestibular_system1.73299749
49MP0002234_abnormal_pharynx_morphology1.72261995
50MP0001970_abnormal_pain_threshold1.70825854
51MP0003045_fibrosis1.69967391
52MP0002557_abnormal_social/conspecific_i1.62029682
53MP0003880_abnormal_central_pattern1.61428166
54MP0003633_abnormal_nervous_system1.60503296
55MP0003631_nervous_system_phenotype1.59705071
56MP0000377_abnormal_hair_follicle1.53009443
57MP0005386_behavior/neurological_phenoty1.52922874
58MP0004924_abnormal_behavior1.52922874
59MP0002066_abnormal_motor_capabilities/c1.51221637
60MP0000955_abnormal_spinal_cord1.50044901
61MP0001299_abnormal_eye_distance/1.46238785
62MP0000920_abnormal_myelination1.46124921
63MP0003879_abnormal_hair_cell1.44346177
64MP0000778_abnormal_nervous_system1.41602029
65MP0003690_abnormal_glial_cell1.34385583
66MP0000569_abnormal_digit_pigmentation1.33729275
67MP0002909_abnormal_adrenal_gland1.32663343
68MP0004811_abnormal_neuron_physiology1.28724349
69MP0002089_abnormal_postnatal_growth/wei1.25919716
70MP0008872_abnormal_physiological_respon1.25065116
71MP0002882_abnormal_neuron_morphology1.23690626
72MP0005083_abnormal_biliary_tract1.23547615
73MP0000678_abnormal_parathyroid_gland1.20377417
74MP0000427_abnormal_hair_cycle1.17658937
75MP0004215_abnormal_myocardial_fiber1.12683141
76MP0004043_abnormal_pH_regulation1.11857487
77MP0003137_abnormal_impulse_conducting1.10014963
78MP0002152_abnormal_brain_morphology1.09954452
79MP0001502_abnormal_circadian_rhythm1.07323579
80MP0005377_hearing/vestibular/ear_phenot1.07126628
81MP0003878_abnormal_ear_physiology1.07126628
82MP0004264_abnormal_extraembryonic_tissu1.06578339
83MP0004510_myositis1.03539504
84MP0005023_abnormal_wound_healing0.99288005
85MP0009931_abnormal_skin_appearance0.98625342
86MP0008260_abnormal_autophagy0.98471733
87MP0004782_abnormal_surfactant_physiolog0.96625225
88MP0002229_neurodegeneration0.96496076
89MP0001177_atelectasis0.96080759
90MP0004947_skin_inflammation0.96023100
91MP0003283_abnormal_digestive_organ0.91805104
92MP0000604_amyloidosis0.88706974
93MP0009053_abnormal_anal_canal0.88483148
94MP0001984_abnormal_olfaction0.88415758
95MP0001188_hyperpigmentation0.87957106
96MP0009780_abnormal_chondrocyte_physiolo0.87868829
97MP0004272_abnormal_basement_membrane0.86817960
98MP0005187_abnormal_penis_morphology0.85626072
99MP0004233_abnormal_muscle_weight0.84174127
100MP0000367_abnormal_coat/_hair0.83358280
101MP0001485_abnormal_pinna_reflex0.83281887
102MP0010769_abnormal_survival0.80141645
103MP0003191_abnormal_cellular_cholesterol0.78754647
104MP0010768_mortality/aging0.76678018
105MP0004484_altered_response_of0.75233142
106MP0001191_abnormal_skin_condition0.74298849
107MP0002254_reproductive_system_inflammat0.73259966
108MP0000747_muscle_weakness0.72804774
109MP0010770_preweaning_lethality0.71673860
110MP0002082_postnatal_lethality0.71673860
111MP0000647_abnormal_sebaceous_gland0.70600487
112MP0002069_abnormal_eating/drinking_beha0.68783560
113MP0000537_abnormal_urethra_morphology0.68451477
114MP0008874_decreased_physiological_sensi0.67512656
115MP0003634_abnormal_glial_cell0.66579325
116MP0004085_abnormal_heartbeat0.66456057
117MP0000751_myopathy0.65217121
118MP0003075_altered_response_to0.64594374
119MP0002877_abnormal_melanocyte_morpholog0.63987692
120MP0003866_abnormal_defecation0.62873039
121MP0005623_abnormal_meninges_morphology0.61454524
122MP0005499_abnormal_olfactory_system0.60695530
123MP0005394_taste/olfaction_phenotype0.60695530
124MP0001851_eye_inflammation0.58263630
125MP0003705_abnormal_hypodermis_morpholog0.58156283
126MP0001765_abnormal_ion_homeostasis0.57842610
127MP0002133_abnormal_respiratory_system0.57695551
128MP0005388_respiratory_system_phenotype0.57695551
129MP0001348_abnormal_lacrimal_gland0.56423117
130MP0001963_abnormal_hearing_physiology0.55808501
131MP0001346_abnormal_lacrimal_gland0.55510554
132MP0003787_abnormal_imprinting0.54765780
133MP0005551_abnormal_eye_electrophysiolog0.54101003
134MP0001943_abnormal_respiration0.54014420
135MP0002752_abnormal_somatic_nervous0.52194060
136MP0002796_impaired_skin_barrier0.52099303
137MP0003646_muscle_fatigue0.51845174
138MP0000627_abnormal_mammary_gland0.51394479
139MP0002249_abnormal_larynx_morphology0.49992140
140MP0008770_decreased_survivor_rate0.48908263
141MP0003956_abnormal_body_size0.48612133
142MP0002638_abnormal_pupillary_reflex0.48579718
143MP0003861_abnormal_nervous_system0.47086847
144MP0002269_muscular_atrophy0.45581028

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)8.94285795
2Abnormality of nail color (HP:0100643)7.73991011
3Progressive cerebellar ataxia (HP:0002073)7.29671539
4Onycholysis (HP:0001806)7.18070398
5Plantar hyperkeratosis (HP:0007556)6.94940417
6Fragile nails (HP:0001808)6.41830592
7Gaze-evoked nystagmus (HP:0000640)6.20639210
8Thick nail (HP:0001805)5.79773682
9Focal motor seizures (HP:0011153)5.56034062
10Palmoplantar hyperkeratosis (HP:0000972)5.51589376
11Alopecia of scalp (HP:0002293)5.50052986
12Dysmetric saccades (HP:0000641)5.41481459
13Hemiplegia (HP:0002301)5.36580229
14Atrophic scars (HP:0001075)5.35234716
15Visual hallucinations (HP:0002367)5.25791757
16Scanning speech (HP:0002168)5.22298919
17Palmar hyperkeratosis (HP:0010765)5.20190888
18Focal seizures (HP:0007359)5.07782798
19Impaired smooth pursuit (HP:0007772)4.97661875
20Intention tremor (HP:0002080)4.96771109
21Abnormality of ocular smooth pursuit (HP:0000617)4.72517074
22Genetic anticipation (HP:0003743)4.72508117
23Dysdiadochokinesis (HP:0002075)4.64331265
24Tetraplegia (HP:0002445)4.50103073
25Pili torti (HP:0003777)4.48077965
26Nail dystrophy (HP:0008404)4.39474025
27Right ventricular cardiomyopathy (HP:0011663)4.31581022
28Abnormality of binocular vision (HP:0011514)4.12044356
29Diplopia (HP:0000651)4.12044356
30Febrile seizures (HP:0002373)4.11891216
31Atonic seizures (HP:0010819)4.11133450
32Myokymia (HP:0002411)4.08842541
33Hemiparesis (HP:0001269)3.92896441
34Abnormal blistering of the skin (HP:0008066)3.92775718
35Broad-based gait (HP:0002136)3.88501023
36Dysmetria (HP:0001310)3.80204298
37Hypotrichosis (HP:0001006)3.77490886
38Neurofibrillary tangles (HP:0002185)3.71673286
39Ridged nail (HP:0001807)3.62945692
40Abnormal hair laboratory examination (HP:0003328)3.60705471
41Truncal ataxia (HP:0002078)3.56897112
42Oligodactyly (hands) (HP:0001180)3.49020332
43Abnormality of the lower motor neuron (HP:0002366)3.44882307
44Annular pancreas (HP:0001734)3.44250036
45Status epilepticus (HP:0002133)3.42467108
46Abnormality of secondary sexual hair (HP:0009888)3.37183802
47Abnormality of the axillary hair (HP:0100134)3.37183802
48Postural tremor (HP:0002174)3.36914966
49Abnormality of the salivary glands (HP:0010286)3.33655071
50Absence seizures (HP:0002121)3.32008870
51Hypoplasia of dental enamel (HP:0006297)3.21303260
52Woolly hair (HP:0002224)3.18484510
53Poor eye contact (HP:0000817)3.18442729
54Cerebral inclusion bodies (HP:0100314)3.13899730
55Epileptic encephalopathy (HP:0200134)3.11437118
56Ventricular fibrillation (HP:0001663)3.05619298
57Horizontal nystagmus (HP:0000666)3.04420947
58Abnormal social behavior (HP:0012433)3.03612601
59Impaired social interactions (HP:0000735)3.03612601
60Abnormality of saccadic eye movements (HP:0000570)3.03024264
61Obstructive sleep apnea (HP:0002870)2.94664477
62Sparse scalp hair (HP:0002209)2.91803767
63Sparse eyelashes (HP:0000653)2.87923628
64Oral leukoplakia (HP:0002745)2.85481149
65Limb ataxia (HP:0002070)2.83585519
66Dialeptic seizures (HP:0011146)2.80011556
67Generalized tonic-clonic seizures (HP:0002069)2.77908782
68Absent eyelashes (HP:0000561)2.77040285
69Shallow orbits (HP:0000586)2.76422349
70Corneal erosion (HP:0200020)2.76285463
71Broad metatarsal (HP:0001783)2.72874951
72Pterygium (HP:0001059)2.70829017
73Lip pit (HP:0100267)2.68676117
74Lower limb asymmetry (HP:0100559)2.65908056
75Agitation (HP:0000713)2.65394357
76Ankyloglossia (HP:0010296)2.64532164
77Abnormality of the corticospinal tract (HP:0002492)2.62412349
78Fragile skin (HP:0001030)2.61220071
79Nonprogressive disorder (HP:0003680)2.60488394
80Aqueductal stenosis (HP:0002410)2.56790988
81Split foot (HP:0001839)2.52101631
82Myotonia (HP:0002486)2.51807630
83Hypoplastic labia majora (HP:0000059)2.51640511
84Selective tooth agenesis (HP:0001592)2.51480468
85Natal tooth (HP:0000695)2.51182209
86Hypoplastic nipples (HP:0002557)2.51004180
87Hand muscle atrophy (HP:0009130)2.48521422
88Advanced eruption of teeth (HP:0006288)2.45623712
89Depression (HP:0000716)2.44215467
90Neuronal loss in central nervous system (HP:0002529)2.37656202
91Confusion (HP:0001289)2.31848059
92Oligodactyly (HP:0012165)2.30131297
93Abnormality of the labia majora (HP:0012881)2.26140565
94Postural instability (HP:0002172)2.25943143
95Abnormal eating behavior (HP:0100738)2.24190503
96Amyotrophic lateral sclerosis (HP:0007354)2.23982846
97Popliteal pterygium (HP:0009756)2.23315997
98Gait ataxia (HP:0002066)2.23085514
99Palmoplantar keratoderma (HP:0000982)2.22623096
100Anonychia (HP:0001798)2.20518404
101Pointed chin (HP:0000307)2.16414693
102Aplasia cutis congenita (HP:0001057)2.15799425
103Stereotypic behavior (HP:0000733)2.15025698
104Erythroderma (HP:0001019)2.15020672
105Mutism (HP:0002300)2.14853448
106Morphological abnormality of the pyramidal tract (HP:0002062)2.13919074
107Erythema (HP:0010783)2.13569365
108Anxiety (HP:0000739)2.12151488
109Supranuclear gaze palsy (HP:0000605)2.11854608
110Increased IgE level (HP:0003212)2.10786431
111Spinal canal stenosis (HP:0003416)2.10616162
112Ankle clonus (HP:0011448)2.06551608
113Blepharitis (HP:0000498)2.05547106
114Bundle branch block (HP:0011710)2.01478384
115Distal upper limb amyotrophy (HP:0007149)2.00579608
116Upper limb amyotrophy (HP:0009129)2.00579608
117Laryngomalacia (HP:0001601)2.00532879
118Oligodontia (HP:0000677)2.00427152
119Congenital ichthyosiform erythroderma (HP:0007431)2.00313084
120Alacrima (HP:0000522)1.99174039
121Psychosis (HP:0000709)1.95608617
122Amelogenesis imperfecta (HP:0000705)1.93324332
123Spastic tetraparesis (HP:0001285)1.93276515
124Slow progression (HP:0003677)1.93188999
125Carious teeth (HP:0000670)1.92137680
126Spastic gait (HP:0002064)1.90625517
127Abnormality of oral frenula (HP:0000190)1.89790189
128Hypohidrosis (HP:0000966)1.88390575
129Aplasia involving bones of the upper limbs (HP:0009823)1.87666976
130Aplasia of the phalanges of the hand (HP:0009802)1.87666976
131Aplasia involving bones of the extremities (HP:0009825)1.87666976
132Hypodontia (HP:0000668)1.87410306
133Fatigable weakness (HP:0003473)1.87245535
134Abnormality of the neuromuscular junction (HP:0003398)1.87245535
135Hyperhidrosis (HP:0000975)1.87169184
136Absent hair (HP:0002298)1.82446856
137Abnormality of placental membranes (HP:0011409)1.81829456
138Amniotic constriction ring (HP:0009775)1.81829456
139Mixed hearing impairment (HP:0000410)1.81776204
140Labial hypoplasia (HP:0000066)1.81676969
141Excessive salivation (HP:0003781)1.81099478
142Drooling (HP:0002307)1.81099478
143Rapidly progressive (HP:0003678)1.79401382
144Anteriorly placed anus (HP:0001545)1.79072834
145Achilles tendon contracture (HP:0001771)1.78653975
146Trigonocephaly (HP:0000243)1.78610330
147Ectropion (HP:0000656)1.78406480
148Narrow palate (HP:0000189)1.78163710
149Pseudobulbar signs (HP:0002200)1.73790724
150Nasolacrimal duct obstruction (HP:0000579)1.72135435
151Clonus (HP:0002169)1.71685378
152Macroorchidism (HP:0000053)1.71282294
153Cerebral hypomyelination (HP:0006808)1.71275141
154Bradycardia (HP:0001662)1.71153994
155Incomplete penetrance (HP:0003829)1.71102772
156Abnormality of permanent molar morphology (HP:0011071)1.70972535
157Abnormality of the dental root (HP:0006486)1.70972535
158Taurodontia (HP:0000679)1.70972535
159Bronchomalacia (HP:0002780)1.69446798
160Apathy (HP:0000741)1.68771886
161Stenosis of the external auditory canal (HP:0000402)1.68281383
162Dry hair (HP:0011359)1.67893387
163Turricephaly (HP:0000262)1.64737492
164Syncope (HP:0001279)1.64450751
165Abnormality of the Achilles tendon (HP:0005109)1.61871146
166Milia (HP:0001056)1.61257586
167Neoplasm of the heart (HP:0100544)1.60405044
168Narrow nasal bridge (HP:0000446)1.60000852
169Impaired vibration sensation in the lower limbs (HP:0002166)1.59175902
170Synostosis involving the elbow (HP:0003938)1.58748097
171Humeroradial synostosis (HP:0003041)1.58748097
172Hypoplastic female external genitalia (HP:0012815)1.55767954
173Prolonged QT interval (HP:0001657)1.55688096
174Upper motor neuron abnormality (HP:0002127)1.55551825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK24.93075459
2RIPK14.81737106
3NTRK34.14286186
4ARAF3.57176495
5WNK13.51311350
6MST1R2.76559359
7EPHA42.68031703
8STK382.67842141
9CAMKK12.60105511
10NTRK22.55742050
11LATS22.50432635
12MAP3K92.21585644
13MAP3K42.18308615
14PRPF4B2.12083584
15CDK191.81001353
16MAP2K41.79759611
17MINK11.79628093
18MET1.76188122
19TNIK1.72863688
20PAK61.69329778
21EPHB11.68571793
22SGK21.66059799
23CAMK1G1.63519934
24DAPK21.59727973
25SGK31.49658258
26PRKD31.47040684
27SGK2231.42440624
28SGK4941.42440624
29CAMK41.40962019
30PRKCH1.40179901
31TYRO31.35714929
32ALK1.32557889
33EEF2K1.30960539
34MAP3K131.30706258
35CDC42BPA1.29215711
36CAMK11.29155820
37CDK121.23597798
38EPHA21.23420386
39PRKCG1.23024262
40TGFBR11.21926948
41PTK61.21772659
42MAPKAPK31.20937958
43RIPK41.18343805
44MARK11.16997495
45BRAF1.15226272
46PNCK1.14965722
47PTK21.12568626
48PIM21.09704254
49CAMK2G1.09509388
50NEK61.08771741
51STK111.08333959
52MAPKAPK51.07607272
53MAP2K71.03936356
54PLK21.02961954
55SIK11.02800615
56MAPK131.02609879
57MAP3K61.02089325
58CDK50.99975134
59EPHB20.98508994
60ROCK20.97892884
61OXSR10.95186245
62RAF10.92413116
63CAMK1D0.90648876
64CAMK2B0.89413704
65CAMK2D0.88669926
66TRIB30.88663792
67SIK20.85887347
68SGK10.84853412
69INSRR0.83211368
70LATS10.81902959
71RPS6KA20.80610140
72FGFR20.79492916
73PHKG10.78353098
74PHKG20.78353098
75RET0.77973066
76NTRK10.76993123
77SMG10.76270954
78PRKG10.73958581
79CDK150.73349072
80MAP3K10.70512661
81CAMK2A0.70040887
82RPS6KA30.67951839
83CDK180.67913457
84HIPK20.67291694
85MARK20.66071896
86DYRK1A0.65593547
87TAOK20.65202527
88CDK11A0.61805721
89GRK50.61491643
90PRKDC0.61354928
91ERBB20.59691961
92FYN0.57542043
93TESK10.57458463
94PINK10.56759401
95CASK0.56697577
96UHMK10.56463859
97JAK10.56056725
98PRKAA10.54847149
99MAP3K30.54609456
100BMX0.54532229
101BRD40.53272291
102PRKACB0.51400748
103SRC0.50750424
104ICK0.50731665
105PDK10.50621570
106DAPK10.49291561
107CDK140.48780116
108LMTK20.48059704
109MAP2K30.46793678
110KSR10.45741860
111MAP3K20.45603881
112CSNK1A10.44531064
113PRKACA0.44253639
114FGFR10.42829191
115MAP3K70.42512492
116MAPK80.42448549
117PDPK10.42348083
118PDGFRA0.41573555
119PRKCA0.41446834
120PRKCB0.40110983
121KSR20.39928918
122MAPK120.39482623
123PRKD10.39233728
124RPS6KB10.38832036
125MAPK100.38193391
126PRKACG0.36706077
127FER0.36381806
128MTOR0.35521432
129STK38L0.34468925
130STK240.33899285
131ERN10.32973067
132FGFR30.32905838
133ROCK10.30929793

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.65346088
2Glutamatergic synapse_Homo sapiens_hsa047243.20937118
3Long-term potentiation_Homo sapiens_hsa047203.00152947
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90066655
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.89439591
6Circadian entrainment_Homo sapiens_hsa047132.68334299
7Salivary secretion_Homo sapiens_hsa049702.64021778
8Long-term depression_Homo sapiens_hsa047302.59201892
9Taste transduction_Homo sapiens_hsa047422.55990917
10GABAergic synapse_Homo sapiens_hsa047272.55430228
11Synaptic vesicle cycle_Homo sapiens_hsa047212.29798175
12Morphine addiction_Homo sapiens_hsa050322.22381132
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09196150
14Gastric acid secretion_Homo sapiens_hsa049712.00378130
15ECM-receptor interaction_Homo sapiens_hsa045121.93859307
16Amphetamine addiction_Homo sapiens_hsa050311.93787538
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92018700
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.91217283
19Type II diabetes mellitus_Homo sapiens_hsa049301.88713993
20Insulin secretion_Homo sapiens_hsa049111.88420928
21Pancreatic secretion_Homo sapiens_hsa049721.82496258
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.80528830
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65026461
24Calcium signaling pathway_Homo sapiens_hsa040201.61012576
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.60476066
26Dopaminergic synapse_Homo sapiens_hsa047281.53152155
27Cholinergic synapse_Homo sapiens_hsa047251.51339157
28cAMP signaling pathway_Homo sapiens_hsa040241.45904406
29Oxytocin signaling pathway_Homo sapiens_hsa049211.40989202
30Thyroid hormone synthesis_Homo sapiens_hsa049181.36537061
31Bile secretion_Homo sapiens_hsa049761.30453355
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26108512
33Estrogen signaling pathway_Homo sapiens_hsa049151.24594588
34GnRH signaling pathway_Homo sapiens_hsa049121.23961268
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16987437
36Renin secretion_Homo sapiens_hsa049241.15820288
37Olfactory transduction_Homo sapiens_hsa047401.14297126
38Serotonergic synapse_Homo sapiens_hsa047261.13016864
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10612533
40Gap junction_Homo sapiens_hsa045401.09965308
41Prion diseases_Homo sapiens_hsa050201.08613027
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06924973
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.04617078
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95266993
45Nitrogen metabolism_Homo sapiens_hsa009100.95059037
46Dilated cardiomyopathy_Homo sapiens_hsa054140.94665270
47Focal adhesion_Homo sapiens_hsa045100.92674588
48Cardiac muscle contraction_Homo sapiens_hsa042600.91529805
49Cocaine addiction_Homo sapiens_hsa050300.91398334
50Inositol phosphate metabolism_Homo sapiens_hsa005620.88523266
51Small cell lung cancer_Homo sapiens_hsa052220.85042973
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82210792
53Vitamin B6 metabolism_Homo sapiens_hsa007500.79882781
54Mineral absorption_Homo sapiens_hsa049780.79161963
55Melanogenesis_Homo sapiens_hsa049160.77886824
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77683449
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.76214673
58Notch signaling pathway_Homo sapiens_hsa043300.75443369
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72275180
60Axon guidance_Homo sapiens_hsa043600.71769486
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69898385
62Circadian rhythm_Homo sapiens_hsa047100.69480353
63Choline metabolism in cancer_Homo sapiens_hsa052310.68015385
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67714388
65Adherens junction_Homo sapiens_hsa045200.64421899
66Insulin signaling pathway_Homo sapiens_hsa049100.63865609
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62585373
68MAPK signaling pathway_Homo sapiens_hsa040100.61807515
69Ras signaling pathway_Homo sapiens_hsa040140.60351511
70Dorso-ventral axis formation_Homo sapiens_hsa043200.59675179
71Oocyte meiosis_Homo sapiens_hsa041140.59554046
72Proteoglycans in cancer_Homo sapiens_hsa052050.58446485
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57436650
74ErbB signaling pathway_Homo sapiens_hsa040120.56048366
75Phototransduction_Homo sapiens_hsa047440.55759624
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53711917
77Vibrio cholerae infection_Homo sapiens_hsa051100.52656923
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51935795
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51455954
80mTOR signaling pathway_Homo sapiens_hsa041500.51355863
81Glioma_Homo sapiens_hsa052140.51107661
82Non-small cell lung cancer_Homo sapiens_hsa052230.50514923
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49461165
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.49299963
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49163223
86Arginine and proline metabolism_Homo sapiens_hsa003300.48304339
87MicroRNAs in cancer_Homo sapiens_hsa052060.48046703
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47676113
89Sphingolipid metabolism_Homo sapiens_hsa006000.47522876
90Renal cell carcinoma_Homo sapiens_hsa052110.45705678
91Hippo signaling pathway_Homo sapiens_hsa043900.45676258
92Thyroid cancer_Homo sapiens_hsa052160.44990471
93Ovarian steroidogenesis_Homo sapiens_hsa049130.43295213
94Fatty acid biosynthesis_Homo sapiens_hsa000610.42615394
95Rap1 signaling pathway_Homo sapiens_hsa040150.41914453
96ABC transporters_Homo sapiens_hsa020100.39444742
97Lysine degradation_Homo sapiens_hsa003100.38234104
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35721349
99Platelet activation_Homo sapiens_hsa046110.35154943
100Arginine biosynthesis_Homo sapiens_hsa002200.34654370
101Glucagon signaling pathway_Homo sapiens_hsa049220.33232662
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.33017947
103Hedgehog signaling pathway_Homo sapiens_hsa043400.32500802
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32309534
105VEGF signaling pathway_Homo sapiens_hsa043700.32207290
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30814185
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.28430499
108Endometrial cancer_Homo sapiens_hsa052130.26502614
109Amoebiasis_Homo sapiens_hsa051460.26128102
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24210608
111Protein digestion and absorption_Homo sapiens_hsa049740.24008602
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.24002598
113Wnt signaling pathway_Homo sapiens_hsa043100.23769611
114Insulin resistance_Homo sapiens_hsa049310.23554256
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23407483
116Chemokine signaling pathway_Homo sapiens_hsa040620.21666193
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21420679
118Glycerolipid metabolism_Homo sapiens_hsa005610.21331942
119Endocytosis_Homo sapiens_hsa041440.21183900
120Basal cell carcinoma_Homo sapiens_hsa052170.20438973
121Tight junction_Homo sapiens_hsa045300.16778225

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