FAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.96160378
2negative regulation of cell killing (GO:0031342)4.96160378
3regulation of dendritic cell antigen processing and presentation (GO:0002604)4.87107978
4regulation of B cell receptor signaling pathway (GO:0050855)4.83929472
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.76257758
6antigen processing and presentation of endogenous antigen (GO:0019883)4.75556182
7positive regulation of natural killer cell differentiation (GO:0032825)4.56943638
8neutrophil activation involved in immune response (GO:0002283)4.47348326
9NIK/NF-kappaB signaling (GO:0038061)4.38305936
10response to interleukin-15 (GO:0070672)4.20000568
11cellular response to interleukin-15 (GO:0071350)4.17712490
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.08723742
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.08723742
14negative regulation of interleukin-12 production (GO:0032695)4.02530039
15positive regulation of antigen processing and presentation (GO:0002579)3.98056714
16positive regulation of humoral immune response (GO:0002922)3.93262362
17regulation of activation of Janus kinase activity (GO:0010533)3.92671521
18regulation of hypersensitivity (GO:0002883)3.85266446
19regulation of interferon-beta biosynthetic process (GO:0045357)3.85252618
20cellular response to type I interferon (GO:0071357)3.84568168
21type I interferon signaling pathway (GO:0060337)3.84568168
22response to type I interferon (GO:0034340)3.82139052
23regulation of T-helper 1 cell differentiation (GO:0045625)3.69400416
24macrophage activation involved in immune response (GO:0002281)3.61882462
25tolerance induction (GO:0002507)3.61175015
26positive regulation of type 2 immune response (GO:0002830)3.59657393
27positive regulation of interleukin-12 production (GO:0032735)3.57647222
28positive regulation of interferon-alpha production (GO:0032727)3.54025837
29regulation of antigen processing and presentation (GO:0002577)3.52159945
30natural killer cell mediated cytotoxicity (GO:0042267)3.52138228
31natural killer cell mediated immunity (GO:0002228)3.52138228
32T-helper 1 type immune response (GO:0042088)3.52081193
33regulation of natural killer cell mediated immunity (GO:0002715)3.49982657
34regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.49982657
35positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.49692380
36negative regulation of T cell mediated immunity (GO:0002710)3.48228718
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.48217075
38response to host immune response (GO:0052572)3.48217075
39regulation of RIG-I signaling pathway (GO:0039535)3.45889413
40regulation of natural killer cell differentiation (GO:0032823)3.43130901
41neutrophil activation (GO:0042119)3.42038041
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41407860
43myeloid dendritic cell differentiation (GO:0043011)3.40463720
44positive regulation of gamma-delta T cell activation (GO:0046645)3.39302903
45response to host (GO:0075136)3.37397103
46response to host defenses (GO:0052200)3.37397103
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37397103
48granulocyte activation (GO:0036230)3.36424694
49cellular response to zinc ion (GO:0071294)3.35093919
50regulation of interferon-alpha production (GO:0032647)3.34633414
51detection of other organism (GO:0098543)3.33020188
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.31072737
53detection of biotic stimulus (GO:0009595)3.30738539
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.30436182
55response to muramyl dipeptide (GO:0032495)3.29878407
56regulation of T cell tolerance induction (GO:0002664)3.28836308
57detection of external biotic stimulus (GO:0098581)3.27667434
58regulation of gamma-delta T cell activation (GO:0046643)3.26627226
59positive regulation of tolerance induction (GO:0002645)3.24771982
60regulation of immunoglobulin secretion (GO:0051023)3.22533558
61cellular response to interferon-beta (GO:0035458)3.21862204
62negative regulation of lymphocyte mediated immunity (GO:0002707)3.20937855
63regulation of necroptotic process (GO:0060544)3.20649863
64positive regulation of natural killer cell mediated immunity (GO:0002717)3.19956354
65immunoglobulin mediated immune response (GO:0016064)3.18967044
66regulation of interleukin-12 biosynthetic process (GO:0045075)3.16419071
67interferon-gamma-mediated signaling pathway (GO:0060333)3.15793800
68positive regulation of T-helper cell differentiation (GO:0045624)3.14225049
69defense response to protozoan (GO:0042832)3.14018420
70regulation of regulatory T cell differentiation (GO:0045589)3.13058262
71positive regulation of T cell mediated cytotoxicity (GO:0001916)3.12161027
72regulation of T cell mediated cytotoxicity (GO:0001914)3.11610804
73positive regulation of alpha-beta T cell proliferation (GO:0046641)3.11177824
74CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.10099198
75detection of bacterium (GO:0016045)3.09583622
76myeloid dendritic cell activation (GO:0001773)3.08535730
77regulation of alpha-beta T cell proliferation (GO:0046640)3.05517499
78* negative thymic T cell selection (GO:0045060)3.05409804
79hydrogen peroxide biosynthetic process (GO:0050665)3.04621870
80positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03754225
81regulation of T-helper 2 cell differentiation (GO:0045628)3.03357886
82B cell receptor signaling pathway (GO:0050853)3.03349378
83response to peptidoglycan (GO:0032494)3.02563440
84positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.99626123
85regulation of leukocyte mediated cytotoxicity (GO:0001910)2.98639677
86regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98527573
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97448580
88positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.96724132
89positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.94860849
90* negative T cell selection (GO:0043383)2.94538778
91negative regulation of lipid storage (GO:0010888)2.94211393
92regulation of interleukin-12 production (GO:0032655)2.88912860
93necroptotic process (GO:0070266)2.88361303
94cellular extravasation (GO:0045123)2.88256927
95lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87035401
96programmed necrotic cell death (GO:0097300)2.86685989
97negative regulation of leukocyte mediated immunity (GO:0002704)2.86390858
98modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.85711056
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.85711056
100modulation by symbiont of host immune response (GO:0052553)2.85711056
101positive regulation by symbiont of host defense response (GO:0052509)2.85711056
102modulation by symbiont of host defense response (GO:0052031)2.85711056
103modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.85711056
104regulation of cell killing (GO:0031341)2.85643135
105cytidine metabolic process (GO:0046087)2.85197726
106cytidine catabolic process (GO:0006216)2.85197726
107cytidine deamination (GO:0009972)2.85197726
108regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.83626614
109antigen processing and presentation via MHC class Ib (GO:0002475)2.83085343
110positive regulation of cell killing (GO:0031343)2.83014048
111positive regulation of monocyte chemotaxis (GO:0090026)2.82937463
112response to interferon-beta (GO:0035456)2.82139961
113leukocyte mediated cytotoxicity (GO:0001909)2.80815241
114membrane raft organization (GO:0031579)2.80173964
115activated T cell proliferation (GO:0050798)2.79745296
116regulation of tolerance induction (GO:0002643)2.79277682
117regulation of gamma-delta T cell differentiation (GO:0045586)2.79205292
118negative regulation of necroptotic process (GO:0060546)2.78977590
119response to protozoan (GO:0001562)2.78863066
120regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.77623137
121response to interferon-alpha (GO:0035455)2.76827894
122positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76458313
123negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.75915901
124necrotic cell death (GO:0070265)2.74177600
125T cell migration (GO:0072678)2.73082456
126dendritic cell differentiation (GO:0097028)2.72726858
127respiratory burst (GO:0045730)2.72401027
128cytokine secretion (GO:0050663)2.72231370
129T cell costimulation (GO:0031295)2.72178570
130negative regulation of viral genome replication (GO:0045071)2.71424422
131positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.68747777
132natural killer cell differentiation (GO:0001779)2.66680751
133Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66411098
134natural killer cell activation (GO:0030101)2.66227699
135leukocyte aggregation (GO:0070486)2.65369620
136JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65166178
137regulation of T-helper cell differentiation (GO:0045622)2.64594981
138regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.64369459
139regulation of cholesterol storage (GO:0010885)2.63071382
140superoxide anion generation (GO:0042554)2.61792568
141reactive oxygen species biosynthetic process (GO:1903409)2.61309285
142growth hormone receptor signaling pathway (GO:0060396)2.60133373
143dendritic cell chemotaxis (GO:0002407)2.59330753
144T-helper cell differentiation (GO:0042093)2.58073035
145CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.58073035
146positive regulation of interleukin-2 production (GO:0032743)2.57394551
147regulation of response to interferon-gamma (GO:0060330)2.55765890
148positive regulation of B cell mediated immunity (GO:0002714)2.54478989
149positive regulation of immunoglobulin mediated immune response (GO:0002891)2.54478989
150cellular response to interferon-alpha (GO:0035457)2.54003776
151positive regulation of interleukin-17 production (GO:0032740)2.53317836
152cellular response to exogenous dsRNA (GO:0071360)2.52038159
153detection of molecule of bacterial origin (GO:0032490)2.51853720
154positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.51461354
155positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.51100525
156positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.49249188
157cellular response to interferon-gamma (GO:0071346)2.48600980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.99946705
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.40519965
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.39692776
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.98941230
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.53370251
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.77309980
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56248296
8* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.51834263
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.44616234
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.28872283
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83408993
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75985221
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.68128478
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.67916185
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67844889
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.63509416
17* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.56513846
18* RXR_22158963_ChIP-Seq_LIVER_Mouse2.52763963
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40369438
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34423076
21* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31635973
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.23745695
23* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.21956543
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16611251
25* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07564332
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93755991
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92806598
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.89468804
29* TP63_17297297_ChIP-ChIP_HaCaT_Human1.77848406
30RUNX_20019798_ChIP-Seq_JUKART_Human1.73605917
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69086321
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.68854986
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68479276
34VDR_24787735_ChIP-Seq_THP-1_Human1.68195473
35NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.67963635
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.66226735
37MYB_26560356_Chip-Seq_TH2_Human1.65432893
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.62569397
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57867662
40* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57116353
41* MAF_26560356_Chip-Seq_TH1_Human1.53586251
42GATA1_22025678_ChIP-Seq_K562_Human1.50801751
43* MYB_26560356_Chip-Seq_TH1_Human1.37981449
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36112049
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35315859
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34278400
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32735911
48SPI1_23547873_ChIP-Seq_NB4_Human1.30844524
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30085212
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29903060
51* NOTCH1_21737748_ChIP-Seq_TLL_Human1.29313424
52PU_27001747_Chip-Seq_BMDM_Mouse1.27326037
53SCL_19346495_ChIP-Seq_HPC-7_Human1.26923531
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26770222
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26231939
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.25353461
57CLOCK_20551151_ChIP-Seq_293T_Human1.23338870
58* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22533980
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22158662
60* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16950077
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16757529
62GATA3_27048872_Chip-Seq_THYMUS_Human1.16304110
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13674516
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13674516
65BRD4_25478319_ChIP-Seq_HGPS_Human1.12450074
66GATA3_26560356_Chip-Seq_TH2_Human1.11664682
67EGR1_19032775_ChIP-ChIP_M12_Human1.11608362
68MYC_22102868_ChIP-Seq_BL_Human1.10370579
69* EGR1_19374776_ChIP-ChIP_THP-1_Human1.10272646
70VDR_24763502_ChIP-Seq_THP-1_Human1.09347853
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09077940
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08158149
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07082964
74TP53_16413492_ChIP-PET_HCT116_Human1.05980494
75* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04875400
76TFEB_21752829_ChIP-Seq_HELA_Human1.04756686
77* SOX2_20726797_ChIP-Seq_SW620_Human1.01349725
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00065851
79SPI1_23127762_ChIP-Seq_K562_Human0.97428766
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96731955
81RUNX1_22412390_ChIP-Seq_EML_Mouse0.95319573
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94718185
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93362437
84VDR_21846776_ChIP-Seq_THP-1_Human0.93117310
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92556750
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90709990
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90437267
88CJUN_26792858_Chip-Seq_BT549_Human0.90067456
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89998558
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86875667
91* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86296440
92* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86296440
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86125051
94TCF7_22412390_ChIP-Seq_EML_Mouse0.84333401
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84251492
96FOXO3_23340844_ChIP-Seq_DLD1_Human0.83543884
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82800190
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82570570
99PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81202333
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80075719
101FLI1_27457419_Chip-Seq_LIVER_Mouse0.79868177
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79383530
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79054776
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.78959094
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78780196
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78688477
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78257260
108GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77818446
109* UTX_26944678_Chip-Seq_JUKART_Human0.76430949
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.76257556
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76059706
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75902507
113* MAF_26560356_Chip-Seq_TH2_Human0.75770995
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75230415
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74857696
116* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74727709
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.74593876
118SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74386824
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74056723
120* TP63_23658742_ChIP-Seq_EP156T_Human0.73071306
121ELK3_25401928_ChIP-Seq_HUVEC_Human0.72639145
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72471261
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72062063
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71616763
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.71141250
126TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.71087354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.55245731
2MP0009785_altered_susceptibility_to3.55574371
3* MP0000685_abnormal_immune_system3.46474375
4MP0003436_decreased_susceptibility_to3.23017545
5MP0002138_abnormal_hepatobiliary_system3.20455233
6* MP0002148_abnormal_hypersensitivity_rea3.11123122
7MP0003724_increased_susceptibility_to3.05046684
8MP0002166_altered_tumor_susceptibility2.93179198
9* MP0005387_immune_system_phenotype2.87872108
10* MP0001790_abnormal_immune_system2.87872108
11MP0005671_abnormal_response_to2.81342685
12* MP0005000_abnormal_immune_tolerance2.70960944
13MP0004510_myositis2.65278947
14MP0002006_tumorigenesis2.62412693
15MP0002254_reproductive_system_inflammat2.60603231
16* MP0005025_abnormal_response_to2.52271876
17* MP0001800_abnormal_humoral_immune2.44159780
18* MP0002419_abnormal_innate_immunity2.35113735
19* MP0002452_abnormal_antigen_presenting2.24405419
20* MP0002723_abnormal_immune_serum2.23310951
21MP0009764_decreased_sensitivity_to2.15861014
22MP0001853_heart_inflammation2.11744244
23MP0002139_abnormal_hepatobiliary_system1.99332173
24* MP0001819_abnormal_immune_cell1.98678625
25* MP0006082_CNS_inflammation1.96838326
26* MP0002420_abnormal_adaptive_immunity1.96034198
27MP0005360_urolithiasis1.93840335
28MP0001533_abnormal_skeleton_physiology1.74330878
29MP0002009_preneoplasia1.70723348
30MP0009840_abnormal_foam_cell1.68107763
31MP0003191_abnormal_cellular_cholesterol1.67738528
32* MP0001845_abnormal_inflammatory_respons1.66351612
33MP0006054_spinal_hemorrhage1.59555583
34MP0003303_peritoneal_inflammation1.58576957
35* MP0008469_abnormal_protein_level1.57100554
36* MP0002405_respiratory_system_inflammati1.56680018
37* MP0004947_skin_inflammation1.53629121
38* MP0003763_abnormal_thymus_physiology1.51589628
39MP0003950_abnormal_plasma_membrane1.50143302
40* MP0000716_abnormal_immune_system1.49494285
41MP0010155_abnormal_intestine_physiology1.47666625
42* MP0005310_abnormal_salivary_gland1.46900653
43MP0000569_abnormal_digit_pigmentation1.43353185
44MP0005464_abnormal_platelet_physiology1.43287369
45MP0005365_abnormal_bile_salt1.42224714
46MP0005085_abnormal_gallbladder_physiolo1.41043873
47MP0003045_fibrosis1.37237942
48MP0003448_altered_tumor_morphology1.36812877
49MP0008260_abnormal_autophagy1.36747883
50* MP0002398_abnormal_bone_marrow1.35520667
51MP0003866_abnormal_defecation1.34776618
52MP0005451_abnormal_body_composition1.31844693
53MP0003252_abnormal_bile_duct1.30414876
54MP0000703_abnormal_thymus_morphology1.29238940
55MP0003186_abnormal_redox_activity1.26583913
56MP0002277_abnormal_respiratory_mucosa1.24036420
57MP0008438_abnormal_cutaneous_collagen1.23663955
58MP0004381_abnormal_hair_follicle1.23449582
59MP0009333_abnormal_splenocyte_physiolog1.16677153
60MP0002933_joint_inflammation1.16362489
61MP0003656_abnormal_erythrocyte_physiolo1.16127128
62MP0002998_abnormal_bone_remodeling1.15560266
63MP0002396_abnormal_hematopoietic_system1.15256400
64MP0000858_altered_metastatic_potential1.14806765
65MP0003075_altered_response_to1.14355072
66MP0001879_abnormal_lymphatic_vessel1.14003725
67MP0001873_stomach_inflammation1.13238182
68MP0002429_abnormal_blood_cell1.13185929
69MP0005076_abnormal_cell_differentiation1.12836298
70MP0004782_abnormal_surfactant_physiolog1.12577946
71MP0001851_eye_inflammation1.12260876
72MP0003828_pulmonary_edema1.12062896
73MP0000465_gastrointestinal_hemorrhage1.11036498
74* MP0001346_abnormal_lacrimal_gland1.10786785
75* MP0009763_increased_sensitivity_to1.06031081
76* MP0001348_abnormal_lacrimal_gland1.05270963
77* MP0000689_abnormal_spleen_morphology1.03616117
78* MP0000609_abnormal_liver_physiology1.01577409
79* MP0002722_abnormal_immune_system1.01241935
80MP0005397_hematopoietic_system_phenotyp0.99914059
81MP0001545_abnormal_hematopoietic_system0.99914059
82MP0000343_altered_response_to0.98856160
83MP0005058_abnormal_lysosome_morphology0.97953038
84MP0003091_abnormal_cell_migration0.97492686
85MP0002877_abnormal_melanocyte_morpholog0.96415496
86MP0003300_gastrointestinal_ulcer0.95529689
87MP0005164_abnormal_response_to0.94647650
88MP0010329_abnormal_lipoprotein_level0.92328776
89MP0003705_abnormal_hypodermis_morpholog0.90096397
90MP0001542_abnormal_bone_strength0.89511739
91* MP0002163_abnormal_gland_morphology0.89467233
92MP0001881_abnormal_mammary_gland0.88974156
93MP0003453_abnormal_keratinocyte_physiol0.88256044
94MP0002132_abnormal_respiratory_system0.88110949
95MP0005166_decreased_susceptibility_to0.88091579
96MP0005167_abnormal_blood-brain_barrier0.87128617
97MP0008875_abnormal_xenobiotic_pharmacok0.86689279
98MP0005083_abnormal_biliary_tract0.86585045
99MP0009278_abnormal_bone_marrow0.86029009
100* MP0000249_abnormal_blood_vessel0.85741765
101MP0003172_abnormal_lysosome_physiology0.85487440
102MP0003806_abnormal_nucleotide_metabolis0.84419858
103MP0005390_skeleton_phenotype0.83562921
104MP0004808_abnormal_hematopoietic_stem0.82811387
105MP0005319_abnormal_enzyme/_coenzyme0.81711533
106MP0000604_amyloidosis0.81109193
107MP0010368_abnormal_lymphatic_system0.79650637
108MP0010352_gastrointestinal_tract_polyps0.79359263
109MP0005623_abnormal_meninges_morphology0.79348183
110MP0002295_abnormal_pulmonary_circulatio0.78679251
111MP0003183_abnormal_peptide_metabolism0.78127981
112MP0002168_other_aberrant_phenotype0.76664450
113MP0005084_abnormal_gallbladder_morpholo0.76640516
114MP0003566_abnormal_cell_adhesion0.76346012
115* MP0002136_abnormal_kidney_physiology0.74663788
116MP0003279_aneurysm0.73514643
117MP0002060_abnormal_skin_morphology0.73365095
118MP0000767_abnormal_smooth_muscle0.71209504
119MP0005275_abnormal_skin_tensile0.70448620
120MP0005023_abnormal_wound_healing0.69284796
121MP0003795_abnormal_bone_structure0.69121762
122* MP0005584_abnormal_enzyme/coenzyme_acti0.67924520
123MP0001958_emphysema0.65911486
124MP0001243_abnormal_dermal_layer0.65185791
125MP0004883_abnormal_blood_vessel0.63962257
126MP0009765_abnormal_xenobiotic_induced0.63815671
127* MP0005332_abnormal_amino_acid0.63750582
128MP0000371_diluted_coat_color0.63445811
129MP0008057_abnormal_DNA_replication0.62688118

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.96241212
2Recurrent gram-negative bacterial infections (HP:0005420)5.29181687
3Recurrent abscess formation (HP:0002722)4.83812713
4Retrobulbar optic neuritis (HP:0100654)4.76736729
5Optic neuritis (HP:0100653)4.76736729
6Orchitis (HP:0100796)4.74238303
7Myositis (HP:0100614)4.71489930
8Recurrent bacterial skin infections (HP:0005406)4.68901819
9Elevated erythrocyte sedimentation rate (HP:0003565)4.68645053
10* Increased IgM level (HP:0003496)4.08023417
11Recurrent fungal infections (HP:0002841)3.86248876
12Mediastinal lymphadenopathy (HP:0100721)3.58722378
13* Abnormal delayed hypersensitivity skin test (HP:0002963)3.55924161
14Stomatitis (HP:0010280)3.53570498
15Abnormality of macrophages (HP:0004311)3.53244956
16Tetraparesis (HP:0002273)3.50871793
17Recurrent skin infections (HP:0001581)3.49144983
18Systemic lupus erythematosus (HP:0002725)3.48486902
19* Vasculitis (HP:0002633)3.43817215
20Keratoconjunctivitis (HP:0001096)3.25405711
21* Autoimmune thrombocytopenia (HP:0001973)3.24525846
22Keratoconjunctivitis sicca (HP:0001097)3.21944011
23Gingivitis (HP:0000230)3.20452870
24Myocardial infarction (HP:0001658)3.17755467
25Recurrent viral infections (HP:0004429)3.10383436
26Recurrent cutaneous fungal infections (HP:0011370)3.05024271
27Chronic mucocutaneous candidiasis (HP:0002728)3.05024271
28Arterial thrombosis (HP:0004420)2.96290868
29Chronic otitis media (HP:0000389)2.93087084
30Spondylolisthesis (HP:0003302)2.92677869
31Aortic aneurysm (HP:0004942)2.91279177
32Pulmonary infiltrates (HP:0002113)2.86802609
33IgA deficiency (HP:0002720)2.86401536
34Recurrent bronchitis (HP:0002837)2.81946317
35Aortic dissection (HP:0002647)2.81345076
36Gastrointestinal infarctions (HP:0005244)2.78440913
37* Abnormality of T cell physiology (HP:0011840)2.73127576
38IgG deficiency (HP:0004315)2.72585130
39* Autoimmune hemolytic anemia (HP:0001890)2.71445707
40Pustule (HP:0200039)2.70894479
41Interstitial pulmonary disease (HP:0006530)2.70887619
42Amyloidosis (HP:0011034)2.69422240
43Meningitis (HP:0001287)2.68760539
44Basal ganglia calcification (HP:0002135)2.65452301
45Deep venous thrombosis (HP:0002625)2.64870424
46Chest pain (HP:0100749)2.64597945
47* Abnormality of T cell number (HP:0011839)2.62977678
48T lymphocytopenia (HP:0005403)2.62977678
49Periodontitis (HP:0000704)2.61815964
50Esophageal varix (HP:0002040)2.60414973
51Gingival bleeding (HP:0000225)2.57852333
52Vertebral compression fractures (HP:0002953)2.57745177
53* Hypergammaglobulinemia (HP:0010702)2.57742766
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.55079177
55Osteolytic defects of the hand bones (HP:0009699)2.55079177
56Agammaglobulinemia (HP:0004432)2.55057980
57Obstructive lung disease (HP:0006536)2.53694370
58Chronic obstructive pulmonary disease (HP:0006510)2.53694370
59Vascular tortuosity (HP:0004948)2.53445065
60Joint hemorrhage (HP:0005261)2.53269175
61Fatigue (HP:0012378)2.52957507
62Dilatation of the ascending aorta (HP:0005111)2.52419275
63Abnormality of the nasal mucosa (HP:0000433)2.50775823
64Peritonitis (HP:0002586)2.50285863
65Hemoptysis (HP:0002105)2.50176687
66Spontaneous hematomas (HP:0007420)2.47783327
67Cellulitis (HP:0100658)2.47053513
68Complement deficiency (HP:0004431)2.45579892
69Prolonged partial thromboplastin time (HP:0003645)2.45022098
70Abnormality of glutamine family amino acid metabolism (HP:0010902)2.45000647
71Pulmonary embolism (HP:0002204)2.42653161
72Arterial tortuosity (HP:0005116)2.42259874
73Abnormality of proline metabolism (HP:0010907)2.41546631
74Hydroxyprolinuria (HP:0003080)2.41546631
75Thick nail (HP:0001805)2.39920975
76* Joint swelling (HP:0001386)2.37811822
77Xanthomatosis (HP:0000991)2.37568556
78Axonal loss (HP:0003447)2.36894545
79Vacuolated lymphocytes (HP:0001922)2.35040104
80Encephalitis (HP:0002383)2.32346932
81Nasal polyposis (HP:0100582)2.32224880
82Polycythemia (HP:0001901)2.30784833
83Recurrent pneumonia (HP:0006532)2.30755262
84Abnormality of the pleura (HP:0002103)2.30025720
85Keratitis (HP:0000491)2.29960665
86Gastrointestinal stroma tumor (HP:0100723)2.28274826
87Increased IgE level (HP:0003212)2.28197845
88Thrombophlebitis (HP:0004418)2.27378897
89Recurrent lower respiratory tract infections (HP:0002783)2.27091802
90Purpura (HP:0000979)2.25856675
91Glomerulopathy (HP:0100820)2.23881593
92IgM deficiency (HP:0002850)2.19826514
93Chronic sinusitis (HP:0011109)2.18666869
94Lymphopenia (HP:0001888)2.18556353
95Gangrene (HP:0100758)2.15174527
96* Urticaria (HP:0001025)2.14989631
97Emphysema (HP:0002097)2.13715494
98Anorexia (HP:0002039)2.13016331
99* Leukocytosis (HP:0001974)2.11303661
100Mitral stenosis (HP:0001718)2.11253949
101Nephritis (HP:0000123)2.10750134
102Skin ulcer (HP:0200042)2.10410857
103Abnormality of the prostate (HP:0008775)2.10362678
104Abnormality of monocarboxylic acid metabolism (HP:0010996)2.10032419
105Combined immunodeficiency (HP:0005387)2.09613393
106Chronic diarrhea (HP:0002028)2.09144393
107Inflammation of the large intestine (HP:0002037)2.08206582
108Epistaxis (HP:0000421)2.07081280
109Panhypogammaglobulinemia (HP:0003139)2.06769617
110Osteomyelitis (HP:0002754)2.05658243
111Acute hepatic failure (HP:0006554)2.04421113
112Abnormality of complement system (HP:0005339)2.04076182
113Verrucae (HP:0200043)2.03652357
114Papilloma (HP:0012740)2.03652357
115Cheilitis (HP:0100825)2.03499376
116Skin rash (HP:0000988)2.02855582
117Premature loss of primary teeth (HP:0006323)2.01880070
118* Abnormality of cells of the lymphoid lineage (HP:0012140)2.01644372
119Xerostomia (HP:0000217)2.01404645
120Slow saccadic eye movements (HP:0000514)2.01148181
121Intrahepatic cholestasis (HP:0001406)2.01073248
122Severe combined immunodeficiency (HP:0004430)2.00969824
123Hemorrhage of the eye (HP:0011885)2.00761369
124Abnormality of the pericardium (HP:0001697)2.00359636
125Hematochezia (HP:0002573)2.00153581
126Abnormality of the common coagulation pathway (HP:0010990)1.98913956
127Mucosal telangiectasiae (HP:0100579)1.98879026
128Glomerulonephritis (HP:0000099)1.98849404
129* Eosinophilia (HP:0001880)1.98703607
130Restrictive lung disease (HP:0002091)1.98446427
131Bronchitis (HP:0012387)1.97521206
132* Abnormality of T cells (HP:0002843)1.96718912
133Abnormality of the peritoneum (HP:0002585)1.96714542
134* Arthralgia (HP:0002829)1.90889443
135Gastrointestinal inflammation (HP:0004386)1.88895535
136Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88423438
137Recurrent sinusitis (HP:0011108)1.87516521
138Persistence of primary teeth (HP:0006335)1.87453722
139Viral hepatitis (HP:0006562)1.85650392
140Lymphoma (HP:0002665)1.85404532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.22530421
2TBK13.65516766
3TYK23.32805187
4IKBKE3.23805663
5JAK33.07629902
6MAP3K132.87968881
7IKBKB2.86985630
8FGFR42.58415784
9MAP4K12.36035098
10TXK2.30151525
11CHUK2.22933357
12PIM22.22682389
13IRAK42.17710022
14JAK12.08117548
15PRPF4B1.89364852
16MST41.78632290
17IRAK31.74435148
18ERN11.69410840
19BLK1.69158193
20RIPK41.67925334
21CSK1.67108202
22FES1.62343840
23EPHB11.54894090
24FGFR31.51900266
25SYK1.51462242
26ZAP701.48095751
27KIT1.43678548
28EIF2AK31.42379789
29BMPR21.41166098
30EPHA31.39306592
31NEK91.29648871
32KDR1.25112363
33PBK1.24131341
34TESK11.22273712
35STK241.21168480
36TEC1.16451565
37JAK21.15493389
38BTK1.11103245
39HCK1.05469102
40ACVR1B1.05449291
41PIM11.04220784
42TGFBR21.01727958
43LCK0.98928818
44PTK60.97602004
45ITK0.97183844
46RPS6KA40.96454994
47GRK70.95763690
48INSRR0.93495858
49MAP3K120.92707203
50EIF2AK20.91857171
51PIK3CG0.89882238
52PRKCQ0.89602319
53STK100.87303484
54TIE10.86511453
55TAOK20.85715366
56TNK20.84649426
57LYN0.84568413
58TAOK10.81329085
59SIK10.80531136
60CAMKK20.79509251
61CSF1R0.78998521
62MELK0.78531139
63BMPR1B0.76563428
64PRKD20.73398260
65ABL20.72257766
66RIPK10.71352501
67CLK10.70557396
68NLK0.70075640
69LRRK20.69050914
70BMX0.68950481
71YES10.66964070
72ARAF0.66940310
73TGFBR10.66386083
74DDR20.65797246
75SIK30.65461056
76CDK60.65198765
77CDC42BPA0.64245615
78SMG10.64235163
79STK40.63615348
80ABL10.61449558
81TRPM70.61399036
82PTK2B0.60031506
83PDGFRB0.58366524
84MATK0.57963518
85DYRK1B0.57779233
86MAP3K20.56759566
87ERBB30.56591352
88MST1R0.56301285
89PKN10.55645687
90FGR0.55065270
91TAOK30.54571347
92MAPK110.54499786
93RAF10.53311920
94PRKCH0.52677293
95AKT30.52292664
96KSR20.52279898
97* PRKCD0.51855947
98EGFR0.50870823
99MYLK0.48296138
100TTN0.48263530
101IGF1R0.47037131
102KSR10.46384085
103MOS0.45373932
104MAPK120.44123915
105IRAK20.42299390
106MAP3K30.42274366
107MAP2K30.41848732
108PDK10.41616753
109HIPK20.40424341
110MAPK70.40169814
111BCKDK0.40006686
112NUAK10.39433889
113* MAPKAPK20.39411806
114PAK30.39404705
115GRK60.37348483
116INSR0.37159097
117MAP2K60.37156922
118IRAK10.36534684
119MARK30.34902115
120MAP3K110.32340725
121MAP3K50.32223688
122WNK10.31970687
123GRK10.31515900
124STK380.30699350
125PRKAA20.30327273
126STK30.29925818
127DAPK30.29796551
128NME20.28829534
129MAPK40.28292572
130MAP3K70.27368265
131MAP3K10.26167378
132RPS6KA50.25578774
133CDK40.24710478
134SRC0.23697139

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.41770752
2* Allograft rejection_Homo sapiens_hsa053303.19554249
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98321238
4* Graft-versus-host disease_Homo sapiens_hsa053322.83711313
5Staphylococcus aureus infection_Homo sapiens_hsa051502.73582459
6Leishmaniasis_Homo sapiens_hsa051402.68634336
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.67903862
8Primary immunodeficiency_Homo sapiens_hsa053402.55069348
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.29784270
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26271905
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.12763422
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07765866
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.00627457
14* Measles_Homo sapiens_hsa051621.93220394
15* Autoimmune thyroid disease_Homo sapiens_hsa053201.89405797
16Malaria_Homo sapiens_hsa051441.83598987
17Asthma_Homo sapiens_hsa053101.82925513
18Legionellosis_Homo sapiens_hsa051341.82399147
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.80544316
20Osteoclast differentiation_Homo sapiens_hsa043801.78542872
21* TNF signaling pathway_Homo sapiens_hsa046681.71060273
22Complement and coagulation cascades_Homo sapiens_hsa046101.68868000
23Viral myocarditis_Homo sapiens_hsa054161.61232669
24* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.58302581
25Pertussis_Homo sapiens_hsa051331.53025801
26Caffeine metabolism_Homo sapiens_hsa002321.52549951
27Toxoplasmosis_Homo sapiens_hsa051451.51998719
28Antigen processing and presentation_Homo sapiens_hsa046121.45497163
29Rheumatoid arthritis_Homo sapiens_hsa053231.44789495
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.43665345
31* Influenza A_Homo sapiens_hsa051641.43621822
32* Type I diabetes mellitus_Homo sapiens_hsa049401.34329680
33Tuberculosis_Homo sapiens_hsa051521.27085206
34Tryptophan metabolism_Homo sapiens_hsa003801.26009048
35B cell receptor signaling pathway_Homo sapiens_hsa046621.24469489
36* Herpes simplex infection_Homo sapiens_hsa051681.23244300
37Chemokine signaling pathway_Homo sapiens_hsa040621.20792255
38Shigellosis_Homo sapiens_hsa051311.17112336
39* Apoptosis_Homo sapiens_hsa042101.16417921
40* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12177266
41Salmonella infection_Homo sapiens_hsa051321.10796622
42Hematopoietic cell lineage_Homo sapiens_hsa046401.09831419
43Phenylalanine metabolism_Homo sapiens_hsa003601.07966741
44T cell receptor signaling pathway_Homo sapiens_hsa046601.07874545
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07719753
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03949560
47Arginine biosynthesis_Homo sapiens_hsa002201.01033274
48PPAR signaling pathway_Homo sapiens_hsa033200.95914609
49* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95766809
50Hepatitis C_Homo sapiens_hsa051600.91867739
51Non-small cell lung cancer_Homo sapiens_hsa052230.90017477
52* African trypanosomiasis_Homo sapiens_hsa051430.89560541
53Viral carcinogenesis_Homo sapiens_hsa052030.86844554
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86100168
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.83970290
56Fatty acid degradation_Homo sapiens_hsa000710.83063051
57Peroxisome_Homo sapiens_hsa041460.80212442
58Chemical carcinogenesis_Homo sapiens_hsa052040.79956540
59Histidine metabolism_Homo sapiens_hsa003400.78693965
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78165031
61* Hepatitis B_Homo sapiens_hsa051610.76991143
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.75868073
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74616710
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74037398
65Phagosome_Homo sapiens_hsa041450.71171267
66Amoebiasis_Homo sapiens_hsa051460.70070612
67Retinol metabolism_Homo sapiens_hsa008300.66598737
68* p53 signaling pathway_Homo sapiens_hsa041150.64492088
69Lysosome_Homo sapiens_hsa041420.63829914
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63600520
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62831878
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61795474
73Renal cell carcinoma_Homo sapiens_hsa052110.61033757
74Prion diseases_Homo sapiens_hsa050200.56972265
75Systemic lupus erythematosus_Homo sapiens_hsa053220.56479245
76Prostate cancer_Homo sapiens_hsa052150.56363192
77Small cell lung cancer_Homo sapiens_hsa052220.56290201
78FoxO signaling pathway_Homo sapiens_hsa040680.54905711
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.51355288
80Prolactin signaling pathway_Homo sapiens_hsa049170.51343052
81Focal adhesion_Homo sapiens_hsa045100.51174787
82Tyrosine metabolism_Homo sapiens_hsa003500.49788770
83Nitrogen metabolism_Homo sapiens_hsa009100.49547954
84* Proteoglycans in cancer_Homo sapiens_hsa052050.49521874
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49397153
86beta-Alanine metabolism_Homo sapiens_hsa004100.48665783
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.47334630
88Vitamin digestion and absorption_Homo sapiens_hsa049770.45872811
89ABC transporters_Homo sapiens_hsa020100.45416681
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45024447
91VEGF signaling pathway_Homo sapiens_hsa043700.43908117
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.43519545
93Endocytosis_Homo sapiens_hsa041440.42789077
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40935275
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40815544
96Acute myeloid leukemia_Homo sapiens_hsa052210.40597128
97Other glycan degradation_Homo sapiens_hsa005110.38537475
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38521796
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.38320120
100HIF-1 signaling pathway_Homo sapiens_hsa040660.37292643
101Bladder cancer_Homo sapiens_hsa052190.36992015
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36060234
103Dorso-ventral axis formation_Homo sapiens_hsa043200.35575977
104Folate biosynthesis_Homo sapiens_hsa007900.34997062
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34977765
106Pancreatic cancer_Homo sapiens_hsa052120.34929509
107HTLV-I infection_Homo sapiens_hsa051660.33230454
108Fatty acid metabolism_Homo sapiens_hsa012120.32562456
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32134451
110Insulin resistance_Homo sapiens_hsa049310.31642948
111mTOR signaling pathway_Homo sapiens_hsa041500.29845874
112Starch and sucrose metabolism_Homo sapiens_hsa005000.29436038
113Chronic myeloid leukemia_Homo sapiens_hsa052200.27857668
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27124892
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26867272
116* MAPK signaling pathway_Homo sapiens_hsa040100.26820451
117Epstein-Barr virus infection_Homo sapiens_hsa051690.26515710
118Platelet activation_Homo sapiens_hsa046110.24933217
119Proteasome_Homo sapiens_hsa030500.24811234
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23448383
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23190804
122Steroid biosynthesis_Homo sapiens_hsa001000.22737133
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.22412029
124MicroRNAs in cancer_Homo sapiens_hsa052060.22394794
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22275146
126Adherens junction_Homo sapiens_hsa045200.21459233
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21361304
128Inositol phosphate metabolism_Homo sapiens_hsa005620.21122552
129* Pathways in cancer_Homo sapiens_hsa052000.20631484
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19064546
131Colorectal cancer_Homo sapiens_hsa052100.19044160
132Glioma_Homo sapiens_hsa052140.18144134

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