FANK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.85328720
2motile cilium assembly (GO:0044458)9.55773660
3piRNA metabolic process (GO:0034587)9.50959779
4binding of sperm to zona pellucida (GO:0007339)9.45537863
5plasma membrane fusion (GO:0045026)9.39882383
6cell-cell recognition (GO:0009988)9.17788915
7cilium movement (GO:0003341)9.04097724
8spermatid development (GO:0007286)8.63798884
9reproduction (GO:0000003)8.54891149
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.53657639
11male meiosis (GO:0007140)8.41657217
12regulation of cilium movement (GO:0003352)7.90872567
13synaptonemal complex organization (GO:0070193)7.65798230
14synaptonemal complex assembly (GO:0007130)7.32114389
15single fertilization (GO:0007338)7.10330451
16left/right axis specification (GO:0070986)6.93685977
17fertilization (GO:0009566)6.17325875
18negative regulation of inclusion body assembly (GO:0090084)6.14770155
19DNA methylation involved in gamete generation (GO:0043046)6.09657947
20spermatogenesis (GO:0007283)6.00293513
21sperm capacitation (GO:0048240)5.99663188
22male gamete generation (GO:0048232)5.98201862
23male meiosis I (GO:0007141)5.85019047
24gamete generation (GO:0007276)5.59235235
25microtubule depolymerization (GO:0007019)5.54978886
26ventricular system development (GO:0021591)5.37657651
27microtubule severing (GO:0051013)5.29890395
28chromosome organization involved in meiosis (GO:0070192)5.07905036
29regulation of inclusion body assembly (GO:0090083)5.07241240
30meiotic nuclear division (GO:0007126)5.02931774
31cellular process involved in reproduction in multicellular organism (GO:0022412)4.96736441
32germ cell development (GO:0007281)4.96549647
33primary alcohol catabolic process (GO:0034310)4.94485491
34meiosis I (GO:0007127)4.81607575
35calcium ion-dependent exocytosis (GO:0017156)4.73762939
36organic cation transport (GO:0015695)4.71534946
37meiotic cell cycle (GO:0051321)4.70985511
38regulation of microtubule-based movement (GO:0060632)4.66526109
39cell recognition (GO:0008037)4.56953117
40axoneme assembly (GO:0035082)4.54890967
41vitamin transmembrane transport (GO:0035461)4.54571578
42cell projection assembly (GO:0030031)4.48205826
43protein localization to cilium (GO:0061512)4.41858025
44seminiferous tubule development (GO:0072520)4.39477849
45multicellular organismal reproductive process (GO:0048609)4.38240200
46diterpenoid biosynthetic process (GO:0016102)4.27407256
47protein polyglutamylation (GO:0018095)4.17122115
48spermatid nucleus differentiation (GO:0007289)4.12172761
49intraciliary transport (GO:0042073)4.12172637
50ethanol metabolic process (GO:0006067)4.08636582
51monoubiquitinated protein deubiquitination (GO:0035520)4.02893124
52left/right pattern formation (GO:0060972)3.78968433
53negative regulation of T cell differentiation in thymus (GO:0033085)3.76423470
54lateral ventricle development (GO:0021670)3.75562255
55chromosome condensation (GO:0030261)3.72129682
56regulation of meiosis I (GO:0060631)3.70005155
57nucleoside diphosphate phosphorylation (GO:0006165)3.69695080
58lung epithelium development (GO:0060428)3.69036260
59one-carbon compound transport (GO:0019755)3.67135842
60smoothened signaling pathway (GO:0007224)3.63569065
61establishment of planar polarity (GO:0001736)3.60419154
62establishment of tissue polarity (GO:0007164)3.60419154
63determination of left/right symmetry (GO:0007368)3.58472547
64pyrimidine-containing compound transmembrane transport (GO:0072531)3.58029602
65cilium organization (GO:0044782)3.57018134
66gene silencing by RNA (GO:0031047)3.55302588
67DNA packaging (GO:0006323)3.55035581
68response to xenobiotic stimulus (GO:0009410)3.53023192
69chaperone-mediated protein complex assembly (GO:0051131)3.49215085
70retinal rod cell development (GO:0046548)3.48635038
71lateral sprouting from an epithelium (GO:0060601)3.46801932
72glycerol ether metabolic process (GO:0006662)3.46656997
73centriole assembly (GO:0098534)3.45147435
74cilium assembly (GO:0042384)3.44747635
75determination of bilateral symmetry (GO:0009855)3.44394477
76meiotic cell cycle process (GO:1903046)3.44303707
77glomerular epithelial cell development (GO:0072310)3.42300203
78nonmotile primary cilium assembly (GO:0035058)3.41462357
79microtubule-based movement (GO:0007018)3.41069540
80specification of symmetry (GO:0009799)3.40629505
81multicellular organismal development (GO:0007275)3.39263518
82centriole replication (GO:0007099)3.39117733
83cilium morphogenesis (GO:0060271)3.37289203
84cytoplasmic microtubule organization (GO:0031122)3.35442873
85establishment of apical/basal cell polarity (GO:0035089)3.34685016
86establishment or maintenance of monopolar cell polarity (GO:0061339)3.33447374
87establishment of monopolar cell polarity (GO:0061162)3.33447374
88GTP biosynthetic process (GO:0006183)3.32794848
89regulation of interleukin-5 production (GO:0032674)3.30873351
90terpenoid biosynthetic process (GO:0016114)3.30278617
91retinoic acid metabolic process (GO:0042573)3.22326217
92cellular component assembly involved in morphogenesis (GO:0010927)3.21532060
93regulation of spindle checkpoint (GO:0090231)3.20797655
94ether metabolic process (GO:0018904)3.19520596
95genitalia morphogenesis (GO:0035112)3.19504813
96single strand break repair (GO:0000012)3.15516223
97negative regulation of B cell mediated immunity (GO:0002713)3.04408264
98negative regulation of immunoglobulin mediated immune response (GO:0002890)3.04408264
99microtubule polymerization or depolymerization (GO:0031109)3.02973077
100polyol catabolic process (GO:0046174)3.01791338
101tolerance induction (GO:0002507)2.99648403
102retinal cone cell development (GO:0046549)2.99281441
103photoreceptor cell maintenance (GO:0045494)2.99178790
104synapsis (GO:0007129)2.97709781
105ethanol oxidation (GO:0006069)2.93925953
106microtubule-based process (GO:0007017)2.93883224
107UTP biosynthetic process (GO:0006228)2.91383536
108protein K11-linked deubiquitination (GO:0035871)2.90515184
109positive regulation of smoothened signaling pathway (GO:0045880)2.87894212
110regulation of centriole replication (GO:0046599)2.87587195
111apical protein localization (GO:0045176)2.86543470
112negative regulation of humoral immune response (GO:0002921)2.86521524
113alditol metabolic process (GO:0019400)2.85068436
114interferon-gamma secretion (GO:0072643)2.84063929
115organelle assembly (GO:0070925)2.82779628
116embryonic camera-type eye development (GO:0031076)2.80990000
117protein refolding (GO:0042026)2.80481572
118regulation of collateral sprouting (GO:0048670)2.76754925
119negative regulation of organelle assembly (GO:1902116)2.76622902
120mitotic sister chromatid cohesion (GO:0007064)2.76384502
121aldehyde catabolic process (GO:0046185)2.73040624
122nucleus organization (GO:0006997)2.72515759
123exogenous drug catabolic process (GO:0042738)2.69918362
124lactate metabolic process (GO:0006089)2.68740685
125amino-acid betaine transport (GO:0015838)2.66526922
126carnitine transport (GO:0015879)2.66526922
127heart looping (GO:0001947)2.61515329
128glutathione derivative metabolic process (GO:1901685)2.60714565
129glutathione derivative biosynthetic process (GO:1901687)2.60714565
130carnitine transmembrane transport (GO:1902603)2.58192635
131regulation of interleukin-13 production (GO:0032656)2.57761810
132gene silencing (GO:0016458)2.57269401
133UTP metabolic process (GO:0046051)2.56080148
134regulation of smoothened signaling pathway (GO:0008589)2.55532503
135phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.54821717
136histone exchange (GO:0043486)2.51923089
137microtubule bundle formation (GO:0001578)2.51178934
138O-glycan processing (GO:0016266)2.51178527
139regulation of acrosome reaction (GO:0060046)2.50140309
140retinol metabolic process (GO:0042572)2.49402275
141glycerol metabolic process (GO:0006071)2.48362557
142guanosine-containing compound biosynthetic process (GO:1901070)2.47889637
143limb development (GO:0060173)2.41478541
144appendage development (GO:0048736)2.41478541
145primary alcohol metabolic process (GO:0034308)2.40706499
146embryonic heart tube morphogenesis (GO:0003143)2.40233925
147phenol-containing compound catabolic process (GO:0019336)2.38324779
148regulation of germinal center formation (GO:0002634)2.37749802
149excretion (GO:0007588)2.34327540
150asymmetric protein localization (GO:0008105)2.33731261
151intra-S DNA damage checkpoint (GO:0031573)2.30483876
152positive regulation of tolerance induction (GO:0002645)2.26811274
153drug catabolic process (GO:0042737)2.20354412
154nucleotide phosphorylation (GO:0046939)2.18414111
155carnitine metabolic process (GO:0009437)2.16834040
156phosphatidylcholine biosynthetic process (GO:0006656)2.16769870
157regulation of cilium assembly (GO:1902017)2.16633325
158neurotransmitter catabolic process (GO:0042135)2.14546815
159fusion of sperm to egg plasma membrane (GO:0007342)12.3402164
160cilium or flagellum-dependent cell motility (GO:0001539)12.3166946
161sperm motility (GO:0030317)11.3572384
162axonemal dynein complex assembly (GO:0070286)11.0401620
163cell wall macromolecule metabolic process (GO:0044036)10.5216699
164cell wall macromolecule catabolic process (GO:0016998)10.5216699
165multicellular organism reproduction (GO:0032504)10.3571303
166acrosome assembly (GO:0001675)10.3096179
167sperm-egg recognition (GO:0035036)10.3022249
168epithelial cilium movement (GO:0003351)10.0356002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.39888421
2EZH2_22144423_ChIP-Seq_EOC_Human5.04048788
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.81721721
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.65489012
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.68118558
6DROSHA_22980978_ChIP-Seq_HELA_Human2.68944309
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.47446614
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.42985538
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.42460072
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23592694
11VDR_22108803_ChIP-Seq_LS180_Human2.18391271
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15231488
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.14918348
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.13526858
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08570136
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08274428
17KAP1_22055183_ChIP-Seq_ESCs_Mouse2.02708168
18* GATA1_26923725_Chip-Seq_HPCs_Mouse2.00269446
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00225012
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91429308
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87168349
22ELK4_26923725_Chip-Seq_MESODERM_Mouse1.83006432
23ZNF274_21170338_ChIP-Seq_K562_Hela1.82439054
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.78398124
25* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78101482
26NR3C1_21868756_ChIP-Seq_MCF10A_Human1.74886252
27AHR_22903824_ChIP-Seq_MCF-7_Human1.72955506
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69479458
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.69436185
30STAT1_17558387_ChIP-Seq_HELA_Human1.65801707
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65545600
32TP53_18474530_ChIP-ChIP_U2OS_Human1.63717499
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.61733377
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.61654015
35* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57306043
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.57155948
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54695876
38* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54140839
39RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.53907039
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52590313
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.51606910
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51052658
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.50095178
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.49598576
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.47588876
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.47230047
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45046991
48KDM2B_26808549_Chip-Seq_REH_Human1.43683013
49FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42766277
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42613877
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.42009542
52AR_21572438_ChIP-Seq_LNCaP_Human1.41770583
53GATA3_21867929_ChIP-Seq_CD8_Mouse1.40455567
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.40008431
55* TP63_23658742_ChIP-Seq_EP156T_Human1.39558246
56RNF2_27304074_Chip-Seq_NSC_Mouse1.39290467
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39048976
58REST_21632747_ChIP-Seq_MESCs_Mouse1.38557053
59SOX2_22085726_ChIP-Seq_NPCs_Mouse1.36950823
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35174673
61* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34717130
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33404990
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33242458
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33136132
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33136132
66STAT3_23295773_ChIP-Seq_U87_Human1.31857954
67* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31054532
68FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.30802954
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.29437062
70GATA3_21867929_ChIP-Seq_TH1_Mouse1.28710376
71CBP_20019798_ChIP-Seq_JUKART_Human1.28497226
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28497226
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.28302111
74* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27498576
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.26833727
76PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.26652188
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26307760
78HNFA_21074721_ChIP-Seq_CACO-2_Human1.26225546
79* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24841897
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24267045
81* PHF8_20622853_ChIP-Seq_HELA_Human1.23069655
82* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.21145633
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20772181
84* TBL1_22424771_ChIP-Seq_293T_Human1.19135326
85P300_19829295_ChIP-Seq_ESCs_Human1.17816004
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17596186
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17062091
88LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.16862494
89* NFYA_21822215_ChIP-Seq_K562_Human1.16267913
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16162933
91SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16074348
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15410996
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.14925316
94TAF15_26573619_Chip-Seq_HEK293_Human1.14878594
95* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13919528
96* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13854883
97SMRT_27268052_Chip-Seq_Bcells_Human1.13530402
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13318053
99RBPJ_21746931_ChIP-Seq_IB4_Human1.13122657
100RUNX2_22187159_ChIP-Seq_PCA_Human1.12383065
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.11937605
102* TCF4_22108803_ChIP-Seq_LS180_Human1.11903702
103BCAT_22108803_ChIP-Seq_LS180_Human1.10382885
104TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09855901
105CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09717837
106* GF1_26923725_Chip-Seq_HPCs_Mouse1.08830868
107P53_22387025_ChIP-Seq_ESCs_Mouse1.08606941
108KLF4_18555785_Chip-Seq_ESCs_Mouse1.07708911
109AR_25329375_ChIP-Seq_VCAP_Human1.06410081
110* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06125134
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06037936
112FOXA1_25552417_ChIP-Seq_VCAP_Human1.05479642
113CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05312099
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05274884
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05124094
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.04952266
117P53_21459846_ChIP-Seq_SAOS-2_Human1.04820079
118GBX2_23144817_ChIP-Seq_PC3_Human1.04819223
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04805223
120* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04422120
121* TCF4_23295773_ChIP-Seq_U87_Human1.03787344
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.02943005
123EWS_26573619_Chip-Seq_HEK293_Human1.02467597
124P300_18555785_Chip-Seq_ESCs_Mouse1.01657857
125* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01363338
126GATA6_21074721_ChIP-Seq_CACO-2_Human1.01159649
127IGF1R_20145208_ChIP-Seq_DFB_Human1.00899191
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.00865864
129ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00801566
130STAT1_20625510_ChIP-Seq_HELA_Human1.00797462
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00377120
132KLF5_25053715_ChIP-Seq_YYC3_Human0.99194970
133OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98942517
134SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98344412
135* ER_23166858_ChIP-Seq_MCF-7_Human0.98195187
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97454332
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97359006
138ERG_20517297_ChIP-Seq_VCAP_Human0.97336047
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96575198
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96200772
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.95754702
142SOX2_18555785_Chip-Seq_ESCs_Mouse0.95639690
143* RUNX1_27514584_Chip-Seq_MCF-7_Human0.95182459
144SPI1_26923725_Chip-Seq_HPCs_Mouse0.94883074
145STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93052003
146* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92644646
147GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92240410
148AR_20517297_ChIP-Seq_VCAP_Human0.91654511
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.91651663
150CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91187018
151SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90921636
152CTCF_18555785_Chip-Seq_ESCs_Mouse0.90885225
153FUS_26573619_Chip-Seq_HEK293_Human0.90512220
154PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90410516
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.90333419
156* GF1B_26923725_Chip-Seq_HPCs_Mouse0.90271633
157SMAD3_21741376_ChIP-Seq_ESCs_Human0.89858899
158NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89394326
159TP63_22573176_ChIP-Seq_HFKS_Human0.89034346
160CTCF_27219007_Chip-Seq_Bcells_Human0.88883994
161* CBP_21632823_ChIP-Seq_H3396_Human0.88595554
162NFYB_21822215_ChIP-Seq_K562_Human0.88353583
163ESET_19884257_ChIP-Seq_ESCs_Mouse0.88335979
164E2F1_18555785_Chip-Seq_ESCs_Mouse0.88048081
165ZFX_18555785_Chip-Seq_ESCs_Mouse0.87870899
166RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87673651
167ETV1_20927104_ChIP-Seq_GIST48_Human0.87553951
168SOX9_26525672_Chip-Seq_HEART_Mouse0.87448764
169RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87367214
170PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87164216
171PU1_27457419_Chip-Seq_LIVER_Mouse0.87055442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.67804240
2MP0001929_abnormal_gametogenesis5.48836617
3MP0008877_abnormal_DNA_methylation5.15426723
4MP0008875_abnormal_xenobiotic_pharmacok4.47325615
5MP0002653_abnormal_ependyma_morphology4.03809740
6MP0002210_abnormal_sex_determination3.79738006
7MP0002132_abnormal_respiratory_system3.55564453
8MP0002161_abnormal_fertility/fecundity3.25888936
9MP0001145_abnormal_male_reproductive3.12674957
10MP0000566_synostosis2.89335613
11MP0000653_abnormal_sex_gland2.88338902
12MP0004043_abnormal_pH_regulation2.73709974
13MP0009780_abnormal_chondrocyte_physiolo2.61528389
14MP0000383_abnormal_hair_follicle2.45603002
15MP0002277_abnormal_respiratory_mucosa2.41038628
16MP0010030_abnormal_orbit_morphology2.32210511
17MP0003646_muscle_fatigue2.30158265
18MP0003136_yellow_coat_color2.24837393
19MP0001984_abnormal_olfaction2.18678247
20MP0002160_abnormal_reproductive_system2.15245425
21MP0005410_abnormal_fertilization13.9172786
22MP0010678_abnormal_skin_adnexa1.84791764
23MP0005083_abnormal_biliary_tract1.84120508
24MP0005623_abnormal_meninges_morphology1.67044376
25MP0004019_abnormal_vitamin_homeostasis1.59236633
26MP0008057_abnormal_DNA_replication1.59044629
27MP0002638_abnormal_pupillary_reflex1.58330019
28MP0002102_abnormal_ear_morphology1.57498898
29MP0005670_abnormal_white_adipose1.56980329
30MP0001485_abnormal_pinna_reflex1.49171826
31MP0002822_catalepsy1.35065811
32MP0008058_abnormal_DNA_repair1.30448747
33MP0000026_abnormal_inner_ear1.28522567
34MP0010094_abnormal_chromosome_stability1.26101636
35MP0005389_reproductive_system_phenotype1.25759838
36MP0009046_muscle_twitch1.25662644
37MP0002282_abnormal_trachea_morphology1.23525384
38MP0001346_abnormal_lacrimal_gland1.21906406
39MP0002735_abnormal_chemical_nociception1.21744742
40MP0000049_abnormal_middle_ear1.20522804
41MP0005248_abnormal_Harderian_gland1.20021337
42MP0002168_other_aberrant_phenotype1.19414623
43MP0004233_abnormal_muscle_weight1.16523942
44MP0002909_abnormal_adrenal_gland1.14110111
45MP0002249_abnormal_larynx_morphology1.12323909
46MP0003718_maternal_effect1.11776586
47MP0000678_abnormal_parathyroid_gland1.07250814
48MP0003938_abnormal_ear_development1.05403979
49MP0009379_abnormal_foot_pigmentation1.03148435
50MP0001324_abnormal_eye_pigmentation1.01486298
51MP0005195_abnormal_posterior_eye1.01381857
52MP0003111_abnormal_nucleus_morphology1.00488309
53MP0005647_abnormal_sex_gland0.99860684
54MP0001299_abnormal_eye_distance/0.99576599
55MP0002876_abnormal_thyroid_physiology0.99381927
56MP0001963_abnormal_hearing_physiology0.93184479
57MP0003880_abnormal_central_pattern0.92342168
58MP0003942_abnormal_urinary_system0.91868001
59MP0003699_abnormal_female_reproductive0.91632872
60MP0001765_abnormal_ion_homeostasis0.90773547
61MP0003693_abnormal_embryo_hatching0.90027283
62MP0003656_abnormal_erythrocyte_physiolo0.89451121
63MP0006276_abnormal_autonomic_nervous0.88565427
64MP0002234_abnormal_pharynx_morphology0.86441921
65MP0001119_abnormal_female_reproductive0.85353146
66MP0008995_early_reproductive_senescence0.85202821
67MP0002116_abnormal_craniofacial_bone0.83900881
68MP0001970_abnormal_pain_threshold0.79720195
69MP0005408_hypopigmentation0.78840744
70MP0005503_abnormal_tendon_morphology0.77828600
71MP0001486_abnormal_startle_reflex0.77055199
72MP0003878_abnormal_ear_physiology0.76782416
73MP0005377_hearing/vestibular/ear_phenot0.76782416
74MP0000955_abnormal_spinal_cord0.72387212
75MP0003786_premature_aging0.71648079
76MP0001879_abnormal_lymphatic_vessel0.71524599
77MP0008007_abnormal_cellular_replicative0.70831390
78MP0004885_abnormal_endolymph0.69296041
79MP0003077_abnormal_cell_cycle0.69167713
80MP0003879_abnormal_hair_cell0.68084324
81MP0009384_cardiac_valve_regurgitation0.67006974
82MP0005451_abnormal_body_composition0.66885399
83MP0003329_amyloid_beta_deposits0.63130219
84MP0005646_abnormal_pituitary_gland0.62692350
85MP0001286_abnormal_eye_development0.61589317
86MP0002882_abnormal_neuron_morphology0.61222773
87MP0001270_distended_abdomen0.60715227
88MP0001502_abnormal_circadian_rhythm0.59881690
89MP0004270_analgesia0.59417904
90MP0003861_abnormal_nervous_system0.58549424
91MP0009745_abnormal_behavioral_response0.57873132
92MP0002092_abnormal_eye_morphology0.57379019
93MP0003943_abnormal_hepatobiliary_system0.57182766
94MP0005551_abnormal_eye_electrophysiolog0.57055183
95MP0005220_abnormal_exocrine_pancreas0.56905373
96MP0008872_abnormal_physiological_respon0.56568475
97MP0000762_abnormal_tongue_morphology0.56389786
98MP0001188_hyperpigmentation0.55425026
99MP0002272_abnormal_nervous_system0.54254781
100MP0005394_taste/olfaction_phenotype0.53816043
101MP0005499_abnormal_olfactory_system0.53816043
102MP0002109_abnormal_limb_morphology0.53015208
103MP0005395_other_phenotype0.51730740
104MP0001730_embryonic_growth_arrest0.50578602
105MP0000358_abnormal_cell_content/0.49710336
106MP0003950_abnormal_plasma_membrane0.49192024
107MP0002736_abnormal_nociception_after0.49039454
108MP0002152_abnormal_brain_morphology0.48957367
109MP0002928_abnormal_bile_duct0.48801778
110MP0008789_abnormal_olfactory_epithelium0.48548895
111MP0003115_abnormal_respiratory_system0.47205435
112MP0001440_abnormal_grooming_behavior0.46813502
113MP0002734_abnormal_mechanical_nocicepti0.46139834
114MP0003787_abnormal_imprinting0.46138825
115MP0003011_delayed_dark_adaptation0.45260615
116MP0002084_abnormal_developmental_patter0.45130963
117MP0001529_abnormal_vocalization0.44372850
118MP0004957_abnormal_blastocyst_morpholog0.43133509
119MP0000778_abnormal_nervous_system0.42300474
120MP0002572_abnormal_emotion/affect_behav0.41204806
121MP0006072_abnormal_retinal_apoptosis0.39386388
122MP0001727_abnormal_embryo_implantation0.39146051
123MP0008932_abnormal_embryonic_tissue0.39063525
124MP0002085_abnormal_embryonic_tissue0.38544722
125MP0001968_abnormal_touch/_nociception0.38274763
126MP0001545_abnormal_hematopoietic_system0.37335766
127MP0005397_hematopoietic_system_phenotyp0.37335766
128MP0005636_abnormal_mineral_homeostasis0.36887558
129MP0003635_abnormal_synaptic_transmissio0.36302362
130MP0005253_abnormal_eye_physiology0.35325739
131MP0002752_abnormal_somatic_nervous0.35164955
132MP0001293_anophthalmia0.34665697
133MP0000534_abnormal_ureter_morphology0.34626762
134MP0003315_abnormal_perineum_morphology0.34586948
135MP0003937_abnormal_limbs/digits/tail_de0.34330362
136MP0001919_abnormal_reproductive_system0.34273307
137MP0002063_abnormal_learning/memory/cond0.34040585
138MP0004811_abnormal_neuron_physiology0.33885471
139MP0004133_heterotaxia0.33159319
140MP0002557_abnormal_social/conspecific_i0.32712122
141MP0004742_abnormal_vestibular_system0.32569412
142MP0005423_abnormal_somatic_nervous0.32323369
143MP0000631_abnormal_neuroendocrine_gland0.32101542
144MP0001697_abnormal_embryo_size0.31850994
145MP0002233_abnormal_nose_morphology0.31272698
146MP0000569_abnormal_digit_pigmentation0.31091119
147MP0003890_abnormal_embryonic-extraembry0.29885654
148MP0001905_abnormal_dopamine_level0.29588680
149MP0005391_vision/eye_phenotype0.28832172
150MP0001672_abnormal_embryogenesis/_devel0.28686029
151MP0005380_embryogenesis_phenotype0.28686029
152MP0000427_abnormal_hair_cycle0.28607807
153MP0000462_abnormal_digestive_system0.28296645
154MP0002229_neurodegeneration0.28221171
155MP0009250_abnormal_appendicular_skeleto0.27497355
156MP0004134_abnormal_chest_morphology0.27371040
157MP0006292_abnormal_olfactory_placode0.27120074

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.10610150
2Abnormal respiratory epithelium morphology (HP:0012253)9.10610150
3Rhinitis (HP:0012384)8.49112361
4Abnormal ciliary motility (HP:0012262)8.27631184
5Chronic bronchitis (HP:0004469)7.59998206
6Infertility (HP:0000789)6.33308946
7Nasal polyposis (HP:0100582)5.73279847
8Bronchiectasis (HP:0002110)4.88393046
9Abnormality of the nasal mucosa (HP:0000433)4.61871571
10Nephronophthisis (HP:0000090)4.44648543
11Male infertility (HP:0003251)4.32609141
12Bronchitis (HP:0012387)4.21708720
13Abnormality of the renal medulla (HP:0100957)3.41432862
14Chronic hepatic failure (HP:0100626)3.32575585
15Abnormality of midbrain morphology (HP:0002418)3.17802719
16Molar tooth sign on MRI (HP:0002419)3.17802719
17Medial flaring of the eyebrow (HP:0010747)3.17068791
18Recurrent sinusitis (HP:0011108)3.10871531
19Recurrent otitis media (HP:0000403)3.10783987
20Abnormal spermatogenesis (HP:0008669)2.88707854
21Atelectasis (HP:0100750)2.78311028
22Tubulointerstitial nephritis (HP:0001970)2.70751642
23Chronic otitis media (HP:0000389)2.54225094
24Tubular atrophy (HP:0000092)2.50303550
25Anencephaly (HP:0002323)2.42693918
26Gait imbalance (HP:0002141)2.33848018
27Pancreatic fibrosis (HP:0100732)2.33110635
28Congenital primary aphakia (HP:0007707)2.31308369
29Tubulointerstitial abnormality (HP:0001969)2.30836167
30Hyperactive renin-angiotensin system (HP:0000841)2.29237681
31Impulsivity (HP:0100710)2.19351402
32Male pseudohermaphroditism (HP:0000037)2.18431838
33Abnormality of the lower motor neuron (HP:0002366)2.18374689
34Azoospermia (HP:0000027)2.14584173
35Postaxial foot polydactyly (HP:0001830)2.14424017
36Gonadotropin excess (HP:0000837)2.14188374
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07526919
38Fibular hypoplasia (HP:0003038)2.05453269
39Nephrogenic diabetes insipidus (HP:0009806)2.05046850
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5294295
41Dynein arm defect of respiratory motile cilia (HP:0012255)11.7360076
42Absent/shortened dynein arms (HP:0200106)11.7360076
43Abnormal respiratory motile cilium physiology (HP:0012261)10.0614900
44Congenital hepatic fibrosis (HP:0002612)1.98974658
45Chronic sinusitis (HP:0011109)1.98031840
46Recurrent bronchitis (HP:0002837)1.96182396
47True hermaphroditism (HP:0010459)1.95485891
48Stage 5 chronic kidney disease (HP:0003774)1.91180427
49Supernumerary spleens (HP:0009799)1.89346429
50Postaxial hand polydactyly (HP:0001162)1.88656915
51Amyotrophic lateral sclerosis (HP:0007354)1.88214559
52Tubulointerstitial fibrosis (HP:0005576)1.87980049
53Poor coordination (HP:0002370)1.86906377
54Aplasia/Hypoplasia of the spleen (HP:0010451)1.83903190
55Furrowed tongue (HP:0000221)1.83630096
56Aplasia/Hypoplasia of the tongue (HP:0010295)1.83592696
57Oculomotor apraxia (HP:0000657)1.82940492
58Asplenia (HP:0001746)1.80988245
59Median cleft lip (HP:0000161)1.79390912
60Microglossia (HP:0000171)1.78933655
61Abnormality of the dental root (HP:0006486)1.78511011
62Taurodontia (HP:0000679)1.78511011
63Abnormality of permanent molar morphology (HP:0011071)1.78511011
64Cystic liver disease (HP:0006706)1.78480898
65Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77905771
66Aplasia/Hypoplasia of the lens (HP:0008063)1.74919023
67Genital tract atresia (HP:0001827)1.74633158
68Abnormality of dentin (HP:0010299)1.72444079
69Pancreatic cysts (HP:0001737)1.72218197
70Vaginal atresia (HP:0000148)1.71946387
71Abnormal rod and cone electroretinograms (HP:0008323)1.67783227
72Facial cleft (HP:0002006)1.67026306
73Preaxial hand polydactyly (HP:0001177)1.66877841
74Polydipsia (HP:0001959)1.66621770
75Abnormal drinking behavior (HP:0030082)1.66621770
76Abnormality of molar morphology (HP:0011070)1.64209506
77Abnormality of molar (HP:0011077)1.64209506
78Abnormality of the renal cortex (HP:0011035)1.61779479
79Abnormality of the dental pulp (HP:0006479)1.60688190
80Renal dysplasia (HP:0000110)1.60575988
81Occipital encephalocele (HP:0002085)1.60283836
82Short ribs (HP:0000773)1.55557740
83Decreased circulating renin level (HP:0003351)1.49364851
84Impaired proprioception (HP:0010831)1.46138677
85Short nail (HP:0001799)1.45132212
86Aplasia/Hypoplasia of the fibula (HP:0006492)1.44978118
87Renal salt wasting (HP:0000127)1.44714790
88Abnormal gallbladder physiology (HP:0012438)1.43082528
89Cholecystitis (HP:0001082)1.43082528
90Abnormality of the anterior horn cell (HP:0006802)1.42372512
91Degeneration of anterior horn cells (HP:0002398)1.42372512
92Papillary thyroid carcinoma (HP:0002895)1.41682431
93Absent epiphyses (HP:0010577)1.41315366
94Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.41315366
95Bile duct proliferation (HP:0001408)1.40431980
96Abnormal biliary tract physiology (HP:0012439)1.40431980
97Retinal dysplasia (HP:0007973)1.40017567
98Hyperkalemia (HP:0002153)1.39496963
99Heterotopia (HP:0002282)1.38798208
100Abnormality of renal excretion (HP:0011036)1.36999448
101Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.34513988
102Spastic tetraparesis (HP:0001285)1.34135999
103Dyschromatopsia (HP:0007641)1.29497045
104Decreased central vision (HP:0007663)1.28288925
105Cone-rod dystrophy (HP:0000548)1.26204818
106Bell-shaped thorax (HP:0001591)1.25479640
107Abnormality of macular pigmentation (HP:0008002)1.25197686
108Retinitis pigmentosa (HP:0000510)1.23808354
109Short thorax (HP:0010306)1.23207865
110Broad distal phalanx of finger (HP:0009836)1.21612273
111Narrow forehead (HP:0000341)1.19268268
112Nephropathy (HP:0000112)1.17319162
113Hyperaldosteronism (HP:0000859)1.16590259
114Prominent nasal bridge (HP:0000426)1.16290535
115Short femoral neck (HP:0100864)1.16056642
116Abnormality of ocular smooth pursuit (HP:0000617)1.15984451
117Hip dysplasia (HP:0001385)1.15331457
118Sclerocornea (HP:0000647)1.14670141
119Abnormality of chloride homeostasis (HP:0011422)1.14283276
120Sloping forehead (HP:0000340)1.14153338
121Absent frontal sinuses (HP:0002688)1.13887360
122Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.13773943
123Aganglionic megacolon (HP:0002251)1.13226250
124Abnormality of the frontal sinuses (HP:0002687)1.12993272
125Broad foot (HP:0001769)1.12854686
126Multicystic kidney dysplasia (HP:0000003)1.12758034
127Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.12152974
128Upper motor neuron abnormality (HP:0002127)1.11985611
129Holoprosencephaly (HP:0001360)1.06722370
130Abnormality of the middle phalanges of the toes (HP:0010183)1.06292300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.23940765
2PDK48.23940765
3PDK25.28407473
4TESK14.53534602
5MST44.28022419
6PRKD34.20546447
7EPHA23.26714715
8ICK3.02312009
9PNCK2.84557024
10BCR2.24242735
11PTK2B2.11663358
12STK242.07010222
13NEK21.98695724
14STK381.83024901
15WNK41.82596915
16MAP3K21.80566810
17STK391.78803392
18STK38L1.69498259
19MAP3K121.56242601
20PLK41.38047876
21ERBB31.28567545
22NME11.25286728
23CASK1.23420429
24TTK1.20046242
25MAPK151.16697080
26INSRR1.16064830
27TYRO31.12186284
28STK31.11337028
29STK161.10575234
30MAP3K71.08682374
31BRAF1.07152338
32MUSK1.06552095
33MAP4K21.06483054
34CCNB11.04830431
35ADRBK20.96769461
36MST1R0.96317580
37EEF2K0.95995714
38DYRK30.90874547
39LATS10.89683548
40CHEK20.89396809
41CDC70.88832646
42EPHB10.86761555
43PDK10.86296847
44MAP3K60.85326558
45TSSK60.82821355
46EPHA40.81636202
47GRK10.80431526
48TRIM280.79916205
49MET0.79810627
50PBK0.79062868
51EPHA30.78853601
52WEE10.77634013
53MAP3K40.75965318
54PINK10.75493805
55ARAF0.75125312
56LATS20.73878927
57NTRK20.71862689
58ERBB20.71711697
59DYRK1B0.71274472
60TLK10.70200962
61PRKCI0.68491395
62FRK0.64878525
63CSK0.60842370
64MAP2K70.58310779
65WNK10.58048359
66IRAK10.54763256
67OXSR10.54569677
68LRRK20.53063474
69CHEK10.51983707
70MAPKAPK50.51621758
71DYRK1A0.50797722
72MAP3K90.50720223
73PLK10.49984688
74MAPKAPK30.49300724
75PAK60.47670731
76AKT30.47040291
77BMPR20.46787537
78FER0.46729891
79CDK190.45662290
80EPHB20.45358643
81PRKCQ0.45098756
82PRKCE0.44881493
83PDPK10.43218614
84TAOK10.43033699
85LMTK20.41649033
86PAK10.41446050
87ADRBK10.40444107
88PASK0.40365760
89PRKD20.40146616
90BUB10.37753248
91CAMK2G0.37683929
92RIPK40.37296366
93CAMK1G0.36711682
94NTRK30.36351403
95TNIK0.36327664
96MAP3K30.36302136
97ATM0.35961669
98PRKCG0.35093063
99PRKACA0.34316354
100SGK2230.34019656
101SGK4940.34019656
102AURKA0.33651668
103BCKDK0.33198687
104MOS0.32239391
105PRKCD0.31959582
106SGK10.31762273
107ATR0.30627480
108PRKAA10.30594709
109BMPR1B0.30419124
110ERBB40.30261975
111ACVR1B0.29873246
112DYRK20.28679352
113PAK30.27799005
114ROCK10.27412894
115MARK10.27004669
116CDK30.26697984
117KSR20.26260079
118CSNK1G20.26030012
119TRPM70.25996164
120TGFBR10.25622247
121RPS6KA20.23947641
122TESK20.23806472
123MYLK0.23787571
124BRSK20.23652066
125MAPK130.23380024
126MAP2K40.23112388
127VRK10.22764401
128PRKCA0.22115287
129BRSK10.21949076
130MARK20.21942193
131IRAK20.20943135
132RAF10.20884009
133WNK30.20789830
134MINK10.20724334
135MAP2K60.20265406
136MAP3K50.18729215
137CDK150.16357736
138NEK60.15783348
139CDK180.15409312
140CAMK2A0.15187005
141CAMKK10.14927856
142SRPK10.13293288
143STK110.13018827
144MTOR0.11749706
145CDK11A0.11646848
146PRKCZ0.10546471
147PLK30.09763986
148RPS6KB10.08893681
149CDK10.08267090
150CDK140.08262084
151CDK20.07252019
152STK100.07068276
153GRK50.06646918
154PLK20.06545037
155CDK120.06501284
156MELK0.06338120
157GSK3B0.06144765
158CDK90.05474379
159PRKG10.04913054

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.21836707
2Basal transcription factors_Homo sapiens_hsa030223.61704149
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.47027851
4Histidine metabolism_Homo sapiens_hsa003403.46823154
5Phenylalanine metabolism_Homo sapiens_hsa003603.44632139
6Pyruvate metabolism_Homo sapiens_hsa006203.30767459
7Tyrosine metabolism_Homo sapiens_hsa003502.90166398
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.77641705
9Linoleic acid metabolism_Homo sapiens_hsa005912.77539074
10Fatty acid biosynthesis_Homo sapiens_hsa000612.70386341
11Oocyte meiosis_Homo sapiens_hsa041142.62219798
12beta-Alanine metabolism_Homo sapiens_hsa004102.49440563
13Glucagon signaling pathway_Homo sapiens_hsa049222.47082863
14Dorso-ventral axis formation_Homo sapiens_hsa043202.32761262
15Fanconi anemia pathway_Homo sapiens_hsa034602.30173776
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.27094983
17Retinol metabolism_Homo sapiens_hsa008302.26342624
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15579838
19Propanoate metabolism_Homo sapiens_hsa006402.12714057
20Amphetamine addiction_Homo sapiens_hsa050311.96480742
21Pentose phosphate pathway_Homo sapiens_hsa000301.91678240
22Huntingtons disease_Homo sapiens_hsa050161.86812884
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.84104116
24Caffeine metabolism_Homo sapiens_hsa002321.81678743
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.78533370
26Ether lipid metabolism_Homo sapiens_hsa005651.68607178
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64793591
28Glycerolipid metabolism_Homo sapiens_hsa005611.64674185
29Selenocompound metabolism_Homo sapiens_hsa004501.61247202
30Tight junction_Homo sapiens_hsa045301.59603845
31RNA transport_Homo sapiens_hsa030131.57612554
32Olfactory transduction_Homo sapiens_hsa047401.54312070
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53155273
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.53154405
35ABC transporters_Homo sapiens_hsa020101.51958439
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.47521501
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43029730
38mRNA surveillance pathway_Homo sapiens_hsa030151.41533993
39Peroxisome_Homo sapiens_hsa041461.39592143
40Collecting duct acid secretion_Homo sapiens_hsa049661.35600084
41Purine metabolism_Homo sapiens_hsa002301.33832444
42Basal cell carcinoma_Homo sapiens_hsa052171.32818138
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.32059131
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31524714
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.27956915
46Long-term potentiation_Homo sapiens_hsa047201.26792157
47Renin secretion_Homo sapiens_hsa049241.22265337
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21683288
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20594522
50Fructose and mannose metabolism_Homo sapiens_hsa000511.19728138
51Synaptic vesicle cycle_Homo sapiens_hsa047211.17841581
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17481855
53Fatty acid degradation_Homo sapiens_hsa000711.15820514
54Cell cycle_Homo sapiens_hsa041101.12131107
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10613370
56Cardiac muscle contraction_Homo sapiens_hsa042601.08766694
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03416392
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02256729
59RNA degradation_Homo sapiens_hsa030180.99270955
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99008167
61PPAR signaling pathway_Homo sapiens_hsa033200.98341504
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.96263769
63Butanoate metabolism_Homo sapiens_hsa006500.94984526
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94484523
65Arachidonic acid metabolism_Homo sapiens_hsa005900.93500543
66Mineral absorption_Homo sapiens_hsa049780.93311112
67Estrogen signaling pathway_Homo sapiens_hsa049150.89425289
68Starch and sucrose metabolism_Homo sapiens_hsa005000.88350041
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87539520
70Taste transduction_Homo sapiens_hsa047420.87518972
71Axon guidance_Homo sapiens_hsa043600.86876697
72Notch signaling pathway_Homo sapiens_hsa043300.86666368
73Nitrogen metabolism_Homo sapiens_hsa009100.86169098
74Homologous recombination_Homo sapiens_hsa034400.85939725
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85138260
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83633642
77Hippo signaling pathway_Homo sapiens_hsa043900.83590734
78Oxidative phosphorylation_Homo sapiens_hsa001900.83354965
79Glutathione metabolism_Homo sapiens_hsa004800.81546446
80Protein export_Homo sapiens_hsa030600.81352054
81Hedgehog signaling pathway_Homo sapiens_hsa043400.78147478
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77203846
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75547029
84Insulin secretion_Homo sapiens_hsa049110.74902567
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74235549
86Steroid biosynthesis_Homo sapiens_hsa001000.73771966
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73352066
88Carbon metabolism_Homo sapiens_hsa012000.72558980
89Ovarian steroidogenesis_Homo sapiens_hsa049130.72108235
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71827141
91Calcium signaling pathway_Homo sapiens_hsa040200.69565880
92Regulation of autophagy_Homo sapiens_hsa041400.68065151
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68047683
94Glutamatergic synapse_Homo sapiens_hsa047240.64716298
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63992663
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63588732
97Circadian entrainment_Homo sapiens_hsa047130.63484633
98Tryptophan metabolism_Homo sapiens_hsa003800.61373239
99Inositol phosphate metabolism_Homo sapiens_hsa005620.61305811
100Pyrimidine metabolism_Homo sapiens_hsa002400.60669847
101Dopaminergic synapse_Homo sapiens_hsa047280.59291866
102VEGF signaling pathway_Homo sapiens_hsa043700.58085081
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.56398611
104Serotonergic synapse_Homo sapiens_hsa047260.54886950
105TGF-beta signaling pathway_Homo sapiens_hsa043500.54399781
106Fat digestion and absorption_Homo sapiens_hsa049750.54382958
107Adherens junction_Homo sapiens_hsa045200.53458128
108Nicotine addiction_Homo sapiens_hsa050330.52980419
109Arginine and proline metabolism_Homo sapiens_hsa003300.50367868
110cAMP signaling pathway_Homo sapiens_hsa040240.50084787
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48373103
112Alzheimers disease_Homo sapiens_hsa050100.48338321
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.47561940
114Salivary secretion_Homo sapiens_hsa049700.47518188
115Parkinsons disease_Homo sapiens_hsa050120.46273348
116Chemical carcinogenesis_Homo sapiens_hsa052040.45950779
117Sphingolipid metabolism_Homo sapiens_hsa006000.45096180
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44381152
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44169952
120AMPK signaling pathway_Homo sapiens_hsa041520.43902820
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.43546745
122Biosynthesis of amino acids_Homo sapiens_hsa012300.43154675
123Gastric acid secretion_Homo sapiens_hsa049710.42954433
124Cocaine addiction_Homo sapiens_hsa050300.42781698
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42322430
126Thyroid hormone synthesis_Homo sapiens_hsa049180.41529954
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41441621
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41102435
129Endocytosis_Homo sapiens_hsa041440.40437095
130Antigen processing and presentation_Homo sapiens_hsa046120.40276645
131Phototransduction_Homo sapiens_hsa047440.40030255
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38722340
133Proteasome_Homo sapiens_hsa030500.37632625
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37496344
135Circadian rhythm_Homo sapiens_hsa047100.37131169
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35999625
137Wnt signaling pathway_Homo sapiens_hsa043100.35706552
138Non-homologous end-joining_Homo sapiens_hsa034500.35693911
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34363052
140Metabolic pathways_Homo sapiens_hsa011000.33847510
141Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33826402
142Alcoholism_Homo sapiens_hsa050340.33688212
143Choline metabolism in cancer_Homo sapiens_hsa052310.31054261
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30714354
145Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28792721
146Pancreatic secretion_Homo sapiens_hsa049720.26652273
147Oxytocin signaling pathway_Homo sapiens_hsa049210.26222205
148Melanogenesis_Homo sapiens_hsa049160.25106682
149Gap junction_Homo sapiens_hsa045400.25083896
150Morphine addiction_Homo sapiens_hsa050320.24396868
151ECM-receptor interaction_Homo sapiens_hsa045120.23703353
152Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23588839
153Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23250511
154Central carbon metabolism in cancer_Homo sapiens_hsa052300.23017472
155Dilated cardiomyopathy_Homo sapiens_hsa054140.22065768
156Renin-angiotensin system_Homo sapiens_hsa046140.22055692
157Nucleotide excision repair_Homo sapiens_hsa034200.21837561
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21688308
159Adipocytokine signaling pathway_Homo sapiens_hsa049200.21599329

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