FANCL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.07737162
2DNA double-strand break processing (GO:0000729)5.04110324
3telomere maintenance via semi-conservative replication (GO:0032201)4.67984017
4DNA strand elongation involved in DNA replication (GO:0006271)4.66689305
5synapsis (GO:0007129)4.55325834
6DNA strand elongation (GO:0022616)4.44788345
7formation of translation preinitiation complex (GO:0001731)4.27158512
8telomere maintenance via recombination (GO:0000722)4.27041409
9DNA replication initiation (GO:0006270)4.25132415
10tRNA methylation (GO:0030488)4.22283684
11DNA replication checkpoint (GO:0000076)4.21570514
12maturation of SSU-rRNA (GO:0030490)4.06504629
13DNA ligation (GO:0006266)4.04446419
14negative regulation of DNA-dependent DNA replication (GO:2000104)4.03875481
15mitotic recombination (GO:0006312)3.95251095
16CENP-A containing nucleosome assembly (GO:0034080)3.94939013
17replication fork processing (GO:0031297)3.91857044
18DNA deamination (GO:0045006)3.86990800
19chromatin remodeling at centromere (GO:0031055)3.85681409
20spliceosomal snRNP assembly (GO:0000387)3.83072571
21mitotic metaphase plate congression (GO:0007080)3.81361480
22proteasome assembly (GO:0043248)3.80521646
23viral transcription (GO:0019083)3.78139494
24ribosomal small subunit biogenesis (GO:0042274)3.77491955
25nucleobase biosynthetic process (GO:0046112)3.75852004
26telomere maintenance via telomere lengthening (GO:0010833)3.74452141
27translational termination (GO:0006415)3.74347682
28regulation of DNA endoreduplication (GO:0032875)3.70046886
29kinetochore organization (GO:0051383)3.57802726
30resolution of meiotic recombination intermediates (GO:0000712)3.57411464
31purine nucleobase biosynthetic process (GO:0009113)3.49259148
32IMP metabolic process (GO:0046040)3.48793032
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47718976
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.46820119
35ribosomal large subunit biogenesis (GO:0042273)3.46475637
36DNA unwinding involved in DNA replication (GO:0006268)3.44245718
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43254937
38DNA replication-independent nucleosome organization (GO:0034724)3.42984563
39DNA replication-independent nucleosome assembly (GO:0006336)3.42984563
40ribonucleoprotein complex biogenesis (GO:0022613)3.42972672
41cotranslational protein targeting to membrane (GO:0006613)3.39955357
42translational elongation (GO:0006414)3.39611502
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.38189681
44protein targeting to ER (GO:0045047)3.36099852
45regulation of mitotic spindle checkpoint (GO:1903504)3.35957078
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.35957078
47metaphase plate congression (GO:0051310)3.34980637
48centriole replication (GO:0007099)3.34788925
49spindle checkpoint (GO:0031577)3.34029122
50transcription-coupled nucleotide-excision repair (GO:0006283)3.33322233
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32329216
52regulation of centriole replication (GO:0046599)3.31911318
53histone H2A acetylation (GO:0043968)3.31860482
54ribosome biogenesis (GO:0042254)3.31191810
55mitotic sister chromatid cohesion (GO:0007064)3.29639256
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.28897469
57negative regulation of mitotic sister chromatid separation (GO:2000816)3.27880400
58negative regulation of sister chromatid segregation (GO:0033046)3.27880400
59negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.27880400
60negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27880400
61negative regulation of mitotic sister chromatid segregation (GO:0033048)3.27880400
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.27341162
63sister chromatid segregation (GO:0000819)3.27186293
64protein localization to endoplasmic reticulum (GO:0070972)3.26595189
65attachment of spindle microtubules to kinetochore (GO:0008608)3.25777671
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25543134
67translational initiation (GO:0006413)3.25216326
68regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.24852523
69mitotic spindle checkpoint (GO:0071174)3.24787621
70kinetochore assembly (GO:0051382)3.23917141
71somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23344529
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.23344529
73negative regulation of DNA recombination (GO:0045910)3.23054278
74negative regulation of chromosome segregation (GO:0051985)3.21938924
75mitotic sister chromatid segregation (GO:0000070)3.21703223
76IMP biosynthetic process (GO:0006188)3.21663570
77rRNA processing (GO:0006364)3.20909198
78non-recombinational repair (GO:0000726)3.19635589
79double-strand break repair via nonhomologous end joining (GO:0006303)3.19635589
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19255446
81postreplication repair (GO:0006301)3.19189785
82mitotic G2/M transition checkpoint (GO:0044818)3.18999216
83protein localization to kinetochore (GO:0034501)3.18591384
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18540868
85histone exchange (GO:0043486)3.18438612
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16916745
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15323395
88establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13479668
89rRNA metabolic process (GO:0016072)3.13393647
90DNA damage response, detection of DNA damage (GO:0042769)3.12521273
91establishment of chromosome localization (GO:0051303)3.12251022
92transcription elongation from RNA polymerase III promoter (GO:0006385)3.12086819
93termination of RNA polymerase III transcription (GO:0006386)3.12086819
94viral mRNA export from host cell nucleus (GO:0046784)3.09912522
95mitotic spindle assembly checkpoint (GO:0007094)3.09581229
96recombinational repair (GO:0000725)3.08163961
97spindle assembly checkpoint (GO:0071173)3.07095354
98translation (GO:0006412)3.06566839
99regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06047444
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06047444
101double-strand break repair via homologous recombination (GO:0000724)3.05713402
102nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05584776
103mitotic nuclear envelope disassembly (GO:0007077)3.04923207
104rRNA modification (GO:0000154)3.04229581
105transcription from RNA polymerase I promoter (GO:0006360)3.02262090
106histone-serine phosphorylation (GO:0035404)3.02128736
107regulation of nuclear cell cycle DNA replication (GO:0033262)3.01305569
108establishment of protein localization to mitochondrial membrane (GO:0090151)3.00552186
109respiratory chain complex IV assembly (GO:0008535)3.00162029
110cellular protein complex disassembly (GO:0043624)2.99118717
111protein localization to chromosome, centromeric region (GO:0071459)2.98537647
112cell cycle G1/S phase transition (GO:0044843)2.98214597
113G1/S transition of mitotic cell cycle (GO:0000082)2.98214597
114negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98043897
115negative regulation of ligase activity (GO:0051352)2.98043897
116regulation of mitotic sister chromatid separation (GO:0010965)2.97213499
117regulation of mitotic sister chromatid segregation (GO:0033047)2.97213499
118regulation of sister chromatid segregation (GO:0033045)2.97213499
119folic acid-containing compound biosynthetic process (GO:0009396)2.96334638
120DNA replication-dependent nucleosome assembly (GO:0006335)2.96233823
121DNA replication-dependent nucleosome organization (GO:0034723)2.96233823
122regulation of helicase activity (GO:0051095)2.96125418
123reciprocal DNA recombination (GO:0035825)2.95965511
124reciprocal meiotic recombination (GO:0007131)2.95965511
1257-methylguanosine mRNA capping (GO:0006370)2.95379837
126meiotic chromosome segregation (GO:0045132)2.94637671
1277-methylguanosine RNA capping (GO:0009452)2.93511194
128RNA capping (GO:0036260)2.93511194
129pseudouridine synthesis (GO:0001522)2.93461698
130histone mRNA metabolic process (GO:0008334)2.92906789
131intra-S DNA damage checkpoint (GO:0031573)2.92454542
132DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92419372
133cullin deneddylation (GO:0010388)2.92218038
134establishment of integrated proviral latency (GO:0075713)2.91818224
135viral life cycle (GO:0019058)2.90760196
136spliceosomal complex assembly (GO:0000245)2.90276184
137telomere organization (GO:0032200)2.90262091
138telomere maintenance (GO:0000723)2.90081877
139signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87908019
140intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87908019
141protein K6-linked ubiquitination (GO:0085020)2.86731564
142signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86708203
143signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86708203
144signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86708203
145DNA catabolic process, exonucleolytic (GO:0000738)2.86611737
146ATP-dependent chromatin remodeling (GO:0043044)2.86596065
147transcription initiation from RNA polymerase I promoter (GO:0006361)2.85183801
148N-terminal protein amino acid acetylation (GO:0006474)2.85092005
149maturation of 5.8S rRNA (GO:0000460)2.83894549
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83492186
151chromosome organization involved in meiosis (GO:0070192)2.80813551
152termination of RNA polymerase I transcription (GO:0006363)2.80493090
153cellular component biogenesis (GO:0044085)2.80390020
154DNA topological change (GO:0006265)2.79362427
155regulation of chromosome segregation (GO:0051983)2.78377982
156protein deneddylation (GO:0000338)2.76961232
157translesion synthesis (GO:0019985)2.75685497
158regulation of mitochondrial translation (GO:0070129)2.75222021
159cytochrome complex assembly (GO:0017004)2.75050678
160energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74585358
161ATP synthesis coupled proton transport (GO:0015986)2.74585358
162regulation of meiosis I (GO:0060631)2.74146019
163response to X-ray (GO:0010165)2.74059312
164protein complex biogenesis (GO:0070271)2.73672200
165DNA strand renaturation (GO:0000733)2.73484566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.68464079
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.17454816
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.02129744
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67423158
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55215937
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.39248417
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.24187196
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15319009
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.13546286
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.12108696
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.11365228
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00415555
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98441949
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91766549
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.87861698
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84358105
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75655641
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73865343
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70507533
20VDR_23849224_ChIP-Seq_CD4+_Human2.61711818
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.60748270
22* FUS_26573619_Chip-Seq_HEK293_Human2.31475791
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30214050
24FOXP3_21729870_ChIP-Seq_TREG_Human2.28505353
25XRN2_22483619_ChIP-Seq_HELA_Human2.27119973
26ZNF274_21170338_ChIP-Seq_K562_Hela2.24550824
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24237568
28* EWS_26573619_Chip-Seq_HEK293_Human2.21739169
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16644789
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13710342
31* DCP1A_22483619_ChIP-Seq_HELA_Human2.11308714
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10021189
33* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08419112
34* ELK1_19687146_ChIP-ChIP_HELA_Human2.03781627
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99898486
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99260215
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97919601
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.97829138
39TTF2_22483619_ChIP-Seq_HELA_Human1.95861910
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95228320
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92830806
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.91416950
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.90404435
44* GABP_19822575_ChIP-Seq_HepG2_Human1.87210930
45VDR_22108803_ChIP-Seq_LS180_Human1.80542792
46IGF1R_20145208_ChIP-Seq_DFB_Human1.77381275
47AR_21909140_ChIP-Seq_LNCAP_Human1.72765953
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72507996
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71888486
50TAF15_26573619_Chip-Seq_HEK293_Human1.70404557
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66669824
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65300490
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65209673
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64811584
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.62687453
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59789629
57* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59253085
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58085417
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57381211
60* P300_19829295_ChIP-Seq_ESCs_Human1.55615212
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55286499
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55263068
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54272657
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.53204875
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53161060
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49531770
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49038516
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47402624
69CIITA_25753668_ChIP-Seq_RAJI_Human1.46162838
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43822086
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42129937
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40539237
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40263746
74KDM5A_27292631_Chip-Seq_BREAST_Human1.39006724
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38808798
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.38698142
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35237155
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32887056
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32849555
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31891023
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29193891
82* NANOG_16153702_ChIP-ChIP_HESCs_Human1.28293868
83MYC_18940864_ChIP-ChIP_HL60_Human1.27760097
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25945130
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24929049
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23187161
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.22610283
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19907193
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.19312703
90GBX2_23144817_ChIP-Seq_PC3_Human1.17641260
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16893051
92* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12575812
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12551132
94* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12068671
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11634915
96SPI1_23547873_ChIP-Seq_NB4_Human1.09879448
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08999661
98* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08934014
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.08345241
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08008258
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07470791
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.06007208
103* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03207618
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02890131
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02853995
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01813254
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99100175
108IRF8_22096565_ChIP-ChIP_GC-B_Human0.98528907
109* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98206832
110* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97343001
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97279574
112IRF1_19129219_ChIP-ChIP_H3396_Human0.97272891
113ER_23166858_ChIP-Seq_MCF-7_Human0.95990793
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95492047
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93291869
116* SMAD3_21741376_ChIP-Seq_EPCs_Human0.92709649
117PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92612497
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92307186
119TFEB_21752829_ChIP-Seq_HELA_Human0.91735604
120TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91639720
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.91232749
122SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90647817
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88663255
124SOX2_19829295_ChIP-Seq_ESCs_Human0.88494433
125NANOG_19829295_ChIP-Seq_ESCs_Human0.88494433
126KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87855322
127* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87763121
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.87301057
129CBP_20019798_ChIP-Seq_JUKART_Human0.86651673
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86651673
131KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86034399
132RNF2_27304074_Chip-Seq_NSC_Mouse0.85873059
133* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84722404
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84367754
135MYC_22102868_ChIP-Seq_BL_Human0.76468907
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76339327
137IRF8_21731497_ChIP-ChIP_J774_Mouse0.76061722
138SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75416158
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73436905
140CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.72453833
141STAT4_19710469_ChIP-ChIP_TH1__Mouse0.72271519
142FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71492090
143MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.69444358
144* SOX17_20123909_ChIP-Seq_XEN_Mouse0.68902387
145RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.68592403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.12388557
2MP0006292_abnormal_olfactory_placode4.36159314
3MP0010094_abnormal_chromosome_stability4.10824121
4MP0004957_abnormal_blastocyst_morpholog3.94304049
5MP0003077_abnormal_cell_cycle3.41173338
6MP0003111_abnormal_nucleus_morphology3.38002203
7MP0008058_abnormal_DNA_repair3.36168321
8MP0008057_abnormal_DNA_replication3.33085437
9MP0003123_paternal_imprinting3.06062171
10MP0009697_abnormal_copulation2.98567174
11MP0008007_abnormal_cellular_replicative2.87539830
12MP0002396_abnormal_hematopoietic_system2.26512714
13MP0008932_abnormal_embryonic_tissue2.23106457
14MP0009379_abnormal_foot_pigmentation2.22769504
15MP0001529_abnormal_vocalization2.13743871
16MP0004510_myositis2.09369798
17MP0005075_abnormal_melanosome_morpholog2.00235363
18MP0002102_abnormal_ear_morphology1.98997017
19MP0006072_abnormal_retinal_apoptosis1.92706081
20MP0001835_abnormal_antigen_presentation1.92184104
21MP0008995_early_reproductive_senescence1.91852970
22MP0003806_abnormal_nucleotide_metabolis1.88576001
23MP0003763_abnormal_thymus_physiology1.80659985
24MP0003718_maternal_effect1.79200159
25MP0003136_yellow_coat_color1.78880148
26MP0003890_abnormal_embryonic-extraembry1.74727273
27MP0008877_abnormal_DNA_methylation1.74124811
28MP0003786_premature_aging1.73161379
29MP0001730_embryonic_growth_arrest1.67582807
30MP0003122_maternal_imprinting1.66242420
31MP0000490_abnormal_crypts_of1.64746519
32MP0000350_abnormal_cell_proliferation1.60869366
33MP0003880_abnormal_central_pattern1.58959549
34MP0000372_irregular_coat_pigmentation1.56030059
35MP0003937_abnormal_limbs/digits/tail_de1.56024668
36MP0005174_abnormal_tail_pigmentation1.55034455
37MP0001293_anophthalmia1.52365552
38MP0003941_abnormal_skin_development1.46847636
39MP0004808_abnormal_hematopoietic_stem1.45709133
40MP0003787_abnormal_imprinting1.44609539
41MP0003186_abnormal_redox_activity1.44567515
42MP0004147_increased_porphyrin_level1.43202887
43MP0001984_abnormal_olfaction1.42551297
44MP0003656_abnormal_erythrocyte_physiolo1.40236896
45MP0005671_abnormal_response_to1.39347106
46MP0002398_abnormal_bone_marrow1.37493567
47MP0006054_spinal_hemorrhage1.37099256
48MP0002736_abnormal_nociception_after1.35664712
49MP0009333_abnormal_splenocyte_physiolog1.31883535
50MP0000313_abnormal_cell_death1.30843416
51MP0002132_abnormal_respiratory_system1.30325513
52MP0000631_abnormal_neuroendocrine_gland1.30280155
53MP0005253_abnormal_eye_physiology1.28801202
54MP0003119_abnormal_digestive_system1.28256365
55MP0001545_abnormal_hematopoietic_system1.26786632
56MP0005397_hematopoietic_system_phenotyp1.26786632
57MP0002019_abnormal_tumor_incidence1.24991596
58MP0002160_abnormal_reproductive_system1.24067174
59MP0002234_abnormal_pharynx_morphology1.23150620
60MP0002233_abnormal_nose_morphology1.23091341
61MP0000689_abnormal_spleen_morphology1.21667118
62MP0002751_abnormal_autonomic_nervous1.21007540
63MP0005646_abnormal_pituitary_gland1.20926734
64MP0010030_abnormal_orbit_morphology1.17701992
65MP0002722_abnormal_immune_system1.17008287
66MP0003121_genomic_imprinting1.16788243
67MP0006036_abnormal_mitochondrial_physio1.16422378
68MP0003195_calcinosis1.15635270
69MP0005551_abnormal_eye_electrophysiolog1.14434046
70* MP0001697_abnormal_embryo_size1.12806686
71MP0000703_abnormal_thymus_morphology1.11042344
72* MP0002210_abnormal_sex_determination1.10961865
73MP0000015_abnormal_ear_pigmentation1.10723995
74MP0001286_abnormal_eye_development1.10322959
75MP0004381_abnormal_hair_follicle1.08836591
76MP0002095_abnormal_skin_pigmentation1.07408181
77MP0002429_abnormal_blood_cell1.06547823
78MP0005367_renal/urinary_system_phenotyp1.06346530
79MP0000516_abnormal_urinary_system1.06346530
80MP0003567_abnormal_fetal_cardiomyocyte1.06332555
81* MP0002080_prenatal_lethality1.06161489
82MP0001764_abnormal_homeostasis1.05656255
83MP0006276_abnormal_autonomic_nervous1.05364239
84* MP0005389_reproductive_system_phenotype1.02711471
85MP0001800_abnormal_humoral_immune1.02542832
86MP0000647_abnormal_sebaceous_gland1.02297705
87MP0005380_embryogenesis_phenotype1.01798598
88MP0001672_abnormal_embryogenesis/_devel1.01798598
89MP0009785_altered_susceptibility_to1.01319777
90* MP0003698_abnormal_male_reproductive0.99100949
91MP0000716_abnormal_immune_system0.96821271
92MP0002090_abnormal_vision0.96570598
93MP0002638_abnormal_pupillary_reflex0.96299002
94* MP0001919_abnormal_reproductive_system0.95596898
95MP0000049_abnormal_middle_ear0.94277841
96MP0005391_vision/eye_phenotype0.93767053
97MP0001853_heart_inflammation0.93687897
98MP0002084_abnormal_developmental_patter0.93401688
99MP0005408_hypopigmentation0.92559515
100* MP0001145_abnormal_male_reproductive0.91091594
101MP0003315_abnormal_perineum_morphology0.90779388
102MP0001485_abnormal_pinna_reflex0.90382343
103MP0005248_abnormal_Harderian_gland0.90370357
104MP0000778_abnormal_nervous_system0.90307511
105MP0010307_abnormal_tumor_latency0.89064732
106MP0009703_decreased_birth_body0.89056307
107MP0002420_abnormal_adaptive_immunity0.88126484
108MP0008789_abnormal_olfactory_epithelium0.88120905
109MP0001819_abnormal_immune_cell0.87462783
110MP0002697_abnormal_eye_size0.85854610
111MP0002938_white_spotting0.84555374
112MP0005187_abnormal_penis_morphology0.84519485
113MP0001177_atelectasis0.84419793
114MP0004215_abnormal_myocardial_fiber0.83635536
115MP0002452_abnormal_antigen_presenting0.83618707
116MP0001324_abnormal_eye_pigmentation0.83572563
117MP0009046_muscle_twitch0.83269011
118MP0000858_altered_metastatic_potential0.83042134
119* MP0001929_abnormal_gametogenesis0.82389313
120MP0002111_abnormal_tail_morphology0.81523823
121MP0001188_hyperpigmentation0.80693524
122MP0000569_abnormal_digit_pigmentation0.79794608
123MP0003984_embryonic_growth_retardation0.79593213
124* MP0000653_abnormal_sex_gland0.79354611
125MP0002166_altered_tumor_susceptibility0.79285102
126MP0000427_abnormal_hair_cycle0.79275329
127MP0002723_abnormal_immune_serum0.79092710
128MP0002085_abnormal_embryonic_tissue0.78296098
129MP0005171_absent_coat_pigmentation0.77931959
130MP0002088_abnormal_embryonic_growth/wei0.76260054
131MP0003943_abnormal_hepatobiliary_system0.75888617
132MP0002086_abnormal_extraembryonic_tissu0.75636849
133MP0001968_abnormal_touch/_nociception0.75065900
134MP0003755_abnormal_palate_morphology0.74635522
135MP0004133_heterotaxia0.74534263
136MP0005084_abnormal_gallbladder_morpholo0.73771046
137MP0003861_abnormal_nervous_system0.73081092
138MP0000566_synostosis0.72003936
139MP0005025_abnormal_response_to0.69973807
140* MP0001119_abnormal_female_reproductive0.69243807
141MP0000678_abnormal_parathyroid_gland0.68807069
142MP0003724_increased_susceptibility_to0.67494256
143MP0002148_abnormal_hypersensitivity_rea0.66277706
144MP0005499_abnormal_olfactory_system0.65548861
145MP0005394_taste/olfaction_phenotype0.65548861
146MP0006035_abnormal_mitochondrial_morpho0.65471406
147MP0002006_tumorigenesis0.65064034
148MP0002405_respiratory_system_inflammati0.65049649
149MP0005000_abnormal_immune_tolerance0.64793570
150MP0002075_abnormal_coat/hair_pigmentati0.63218615

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.76383358
2Reticulocytopenia (HP:0001896)4.18577423
3Abnormal number of erythroid precursors (HP:0012131)4.10310834
4Abnormality of cells of the erythroid lineage (HP:0012130)4.05461858
5Breast hypoplasia (HP:0003187)3.81636188
6Abnormality of the anterior horn cell (HP:0006802)3.61537708
7Degeneration of anterior horn cells (HP:0002398)3.61537708
8Volvulus (HP:0002580)3.57964864
9Abnormality of the labia minora (HP:0012880)3.54358197
1011 pairs of ribs (HP:0000878)3.36696533
11Aplastic anemia (HP:0001915)3.35236464
12Oral leukoplakia (HP:0002745)3.26964251
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.17361495
14Aplasia/Hypoplasia of the sacrum (HP:0008517)3.14936401
15Chromsome breakage (HP:0040012)3.11093010
16Acute encephalopathy (HP:0006846)3.02717736
17* Abnormality of the preputium (HP:0100587)3.00844796
18Microretrognathia (HP:0000308)2.96177207
19Abnormal lung lobation (HP:0002101)2.87392667
20* Meckel diverticulum (HP:0002245)2.84077695
21Macrocytic anemia (HP:0001972)2.83092760
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81058551
23Progressive macrocephaly (HP:0004481)2.78687338
24* Abnormality of the ileum (HP:0001549)2.74200831
25Absent thumb (HP:0009777)2.74049172
26Type I transferrin isoform profile (HP:0003642)2.73760290
27* Abnormality of chromosome stability (HP:0003220)2.72764774
28Microvesicular hepatic steatosis (HP:0001414)2.70750289
29Pallor (HP:0000980)2.70031699
30* Aplasia/Hypoplasia of the uvula (HP:0010293)2.67492206
31* Myelodysplasia (HP:0002863)2.63078154
32Selective tooth agenesis (HP:0001592)2.62977596
333-Methylglutaconic aciduria (HP:0003535)2.61269298
34Rough bone trabeculation (HP:0100670)2.59181364
35* Small intestinal stenosis (HP:0012848)2.59021638
36* Duodenal stenosis (HP:0100867)2.59021638
37Intestinal atresia (HP:0011100)2.56675436
38Patellar aplasia (HP:0006443)2.50263578
39Lipid accumulation in hepatocytes (HP:0006561)2.48699017
40Hyperglycinemia (HP:0002154)2.45171892
41Colon cancer (HP:0003003)2.44670886
42Medulloblastoma (HP:0002885)2.44447117
43Agnosia (HP:0010524)2.43129633
44Abnormal number of incisors (HP:0011064)2.40228168
45Hepatocellular necrosis (HP:0001404)2.39498079
46Premature graying of hair (HP:0002216)2.39479489
47Medial flaring of the eyebrow (HP:0010747)2.36216986
48Supernumerary spleens (HP:0009799)2.34410900
49Aplasia/Hypoplasia of the patella (HP:0006498)2.33271608
50Hepatic necrosis (HP:0002605)2.33149805
51Cerebral edema (HP:0002181)2.32648899
52Embryonal renal neoplasm (HP:0011794)2.32511303
53Increased serum lactate (HP:0002151)2.30658038
54Mitochondrial inheritance (HP:0001427)2.29998655
55Oligodactyly (hands) (HP:0001180)2.29388528
56Hypoplasia of the pons (HP:0012110)2.29270936
57IgM deficiency (HP:0002850)2.27305467
58Cerebral hypomyelination (HP:0006808)2.25600988
59Cleft eyelid (HP:0000625)2.25148034
60Bifid tongue (HP:0010297)2.24678489
61Molar tooth sign on MRI (HP:0002419)2.22933067
62Abnormality of midbrain morphology (HP:0002418)2.22933067
63Abnormality of pyrimidine metabolism (HP:0004353)2.21545621
64Acute necrotizing encephalopathy (HP:0006965)2.20913799
65* Bone marrow hypocellularity (HP:0005528)2.20248353
66Increased CSF lactate (HP:0002490)2.18733710
67Congenital primary aphakia (HP:0007707)2.16841546
68Gonadotropin excess (HP:0000837)2.14637323
69* Abnormality of the duodenum (HP:0002246)2.14114724
70Nephronophthisis (HP:0000090)2.13752531
71Pancytopenia (HP:0001876)2.12865937
72Horseshoe kidney (HP:0000085)2.11771167
73Gait imbalance (HP:0002141)2.10746978
74* Sloping forehead (HP:0000340)2.08488461
75Septo-optic dysplasia (HP:0100842)2.08297930
76True hermaphroditism (HP:0010459)2.07878274
77* Clubbing of toes (HP:0100760)2.05624829
78Exertional dyspnea (HP:0002875)2.04609545
79Bile duct proliferation (HP:0001408)2.03167665
80Abnormal biliary tract physiology (HP:0012439)2.03167665
81Ependymoma (HP:0002888)2.02559821
82Nephrogenic diabetes insipidus (HP:0009806)2.02091236
83Abnormal mitochondria in muscle tissue (HP:0008316)2.01422598
84Rhabdomyosarcoma (HP:0002859)2.01375500
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01371311
86Carpal bone hypoplasia (HP:0001498)2.01303435
87Optic nerve coloboma (HP:0000588)2.00498193
88Abnormality of the pons (HP:0007361)2.00143422
89Sparse eyelashes (HP:0000653)1.99852824
90Genital tract atresia (HP:0001827)1.99049067
91Abnormality of the musculature of the pelvis (HP:0001469)1.98851913
92Abnormality of the hip-girdle musculature (HP:0001445)1.98851913
93Abnormal trabecular bone morphology (HP:0100671)1.98652723
94Abnormality of serum amino acid levels (HP:0003112)1.98326057
95Facial cleft (HP:0002006)1.97571815
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96598309
97Cellular immunodeficiency (HP:0005374)1.96545330
98Lymphoma (HP:0002665)1.95350832
99Vaginal atresia (HP:0000148)1.93523651
100Methylmalonic acidemia (HP:0002912)1.93255509
101Atrophy/Degeneration involving motor neurons (HP:0007373)1.93057107
102* Triphalangeal thumb (HP:0001199)1.92879371
103Preaxial hand polydactyly (HP:0001177)1.90854023
104Aplasia/Hypoplasia of the tongue (HP:0010295)1.90693902
105Absent forearm bone (HP:0003953)1.89798576
106Aplasia involving forearm bones (HP:0009822)1.89798576
107Renal Fanconi syndrome (HP:0001994)1.89448660
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87810084
109Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87810084
110Glioma (HP:0009733)1.87152259
111Abnormality of methionine metabolism (HP:0010901)1.86771826
112Type 2 muscle fiber atrophy (HP:0003554)1.86523742
113Limb-girdle muscle atrophy (HP:0003797)1.86105793
114Increased hepatocellular lipid droplets (HP:0006565)1.85155347
115Muscle fiber atrophy (HP:0100295)1.84180307
116Petechiae (HP:0000967)1.83994486
117Abnormality of reticulocytes (HP:0004312)1.81317533
118Pancreatic cysts (HP:0001737)1.80291779
119Nephroblastoma (Wilms tumor) (HP:0002667)1.79599436
120Abnormal protein glycosylation (HP:0012346)1.79521971
121Abnormal glycosylation (HP:0012345)1.79521971
122Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79521971
123Abnormal protein N-linked glycosylation (HP:0012347)1.79521971
124Ectopic kidney (HP:0000086)1.79139074
125Pancreatic fibrosis (HP:0100732)1.78508093
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78366364
127Gastrointestinal atresia (HP:0002589)1.77869968
128Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77091702
129Hyperglycinuria (HP:0003108)1.77030721
130Missing ribs (HP:0000921)1.76869695
131Abnormality of serine family amino acid metabolism (HP:0010894)1.76564433
132Abnormality of glycine metabolism (HP:0010895)1.76564433
133Increased serum pyruvate (HP:0003542)1.75632917
134Pancreatic islet-cell hyperplasia (HP:0004510)1.75246155
135Absent radius (HP:0003974)1.74886338
136Exercise intolerance (HP:0003546)1.74670586
137Median cleft lip (HP:0000161)1.74495509
138Increased nuchal translucency (HP:0010880)1.73754913
139* Astigmatism (HP:0000483)1.72213305
140Reduced antithrombin III activity (HP:0001976)1.71825000
141Duplicated collecting system (HP:0000081)1.71092529
142Hypoplasia of the radius (HP:0002984)1.70524446
143Abnormality of the astrocytes (HP:0100707)1.70319285
144Astrocytoma (HP:0009592)1.70319285
145Neoplasm of the colon (HP:0100273)1.70208853
146Abnormal spermatogenesis (HP:0008669)1.69372678
147Thrombocytosis (HP:0001894)1.69132661
148Abnormality of the renal medulla (HP:0100957)1.68646983
149Asplenia (HP:0001746)1.68373114
150Dandy-Walker malformation (HP:0001305)1.68271695
151Male pseudohermaphroditism (HP:0000037)1.68160891
152Optic nerve hypoplasia (HP:0000609)1.67625481
153Sclerocornea (HP:0000647)1.67580834
154Lactic acidosis (HP:0003128)1.66709877
155Respiratory failure (HP:0002878)1.66692854
156Postaxial foot polydactyly (HP:0001830)1.65890016
157Congenital, generalized hypertrichosis (HP:0004540)1.65519588
158Anencephaly (HP:0002323)1.65309930
159Oligodactyly (HP:0012165)1.64674342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.18256727
2BUB14.57922582
3WEE13.58980566
4BRSK23.42199374
5EIF2AK12.96598953
6CDC72.90477435
7VRK12.63885231
8NUAK12.57585141
9WNK32.51118789
10SRPK12.42501972
11TRIM282.26884716
12ACVR1B2.04834975
13TLK12.04616992
14TSSK62.02594277
15BMPR1B2.01988409
16NME21.97129864
17VRK21.94160560
18MST41.93803702
19CDK71.93468854
20TNIK1.91173348
21PNCK1.89356790
22EIF2AK31.85585314
23PLK41.79031282
24BRSK11.70108202
25TXK1.69107745
26MKNK11.65082563
27PLK11.63258404
28MAP4K21.60137731
29RPS6KA41.59982094
30DYRK31.57235525
31PASK1.50877330
32MAP4K11.50750490
33TTK1.50598328
34PLK21.50219893
35CAMKK21.47227812
36ATR1.44931337
37FRK1.40996766
38CCNB11.40882249
39PLK31.38586279
40PBK1.37853364
41NEK21.37169795
42MKNK21.36683023
43BCR1.34335694
44AURKB1.34012330
45PIM21.31421097
46CASK1.31152887
47PDK21.22341917
48TESK21.16826461
49NEK11.15121036
50CSNK1G11.11058567
51ADRBK21.10957529
52MAPK131.03502296
53ZAK1.00180707
54BCKDK0.99787215
55AURKA0.99699101
56TAF10.98792550
57EPHA40.93811370
58STK30.90452121
59CSNK1G30.90174055
60STK40.89929007
61CHEK20.89374576
62RPS6KB20.89280861
63TGFBR10.89168070
64FLT30.88390444
65STK38L0.88163995
66TEC0.86813474
67MAP3K80.85701278
68BRAF0.84909922
69OXSR10.84817387
70PIM10.84666863
71CDK30.83860470
72MAP3K40.83836548
73EIF2AK20.82526078
74CSNK1G20.82179032
75CDK40.81598385
76KDR0.81167327
77RPS6KA50.78391933
78CSNK2A10.75300753
79BTK0.75160676
80CDK80.69234030
81IKBKB0.67925355
82CHEK10.66918013
83CSNK1A1L0.66679789
84NME10.66404856
85FGFR20.65606530
86INSRR0.64648649
87MINK10.64628187
88CSNK2A20.62187663
89DAPK10.62083875
90STK390.61814328
91FGFR10.61405946
92YES10.60924654
93NLK0.60106452
94CLK10.59883017
95MAP2K30.59546068
96LATS10.57990035
97ERBB40.57217094
98BRD40.56554342
99ATM0.55844243
100PAK40.54875025
101ERBB30.53987687
102IRAK40.53334672
103CSF1R0.53021421
104ZAP700.50176876
105NEK90.49864050
106PRKCG0.47006968
107CDK20.46618311
108ARAF0.46344577
109RPS6KA60.46028828
110PRKCE0.44707660
111CDK190.44507453
112STK100.44354807
113TAOK20.43091545
114STK240.42419053
115CSNK1E0.41464655
116PRKDC0.40953327
117MUSK0.40610573
118KIT0.40392087
119DYRK1B0.40276478
120CDK60.39288738
121RPS6KC10.39011188
122RPS6KL10.39011188
123PKN10.38957564
124MAP2K70.37827860
125UHMK10.37595539
126CHUK0.37006899
127CDK10.35527193
128IKBKE0.34903982
129MAP3K140.34899890
130CSNK1A10.34450394
131LYN0.34358085
132SYK0.34083796
133PINK10.32559047
134DYRK20.32321740
135MARK10.31867947
136CDK120.31709071
137MARK30.31638984
138IRAK30.31111608
139MAPKAPK50.30981961
140SIK30.30760189
141GRK10.30399978
142CDK90.30255705
143PAK10.29926436
144CSNK1D0.28689738
145MAP3K120.27649096

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.94601834
2Mismatch repair_Homo sapiens_hsa034304.28941001
3Ribosome_Homo sapiens_hsa030103.97410619
4Proteasome_Homo sapiens_hsa030503.58454689
5RNA polymerase_Homo sapiens_hsa030203.37976311
6Homologous recombination_Homo sapiens_hsa034403.27451294
7Spliceosome_Homo sapiens_hsa030403.19940412
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11895488
9Base excision repair_Homo sapiens_hsa034102.88563774
10Nucleotide excision repair_Homo sapiens_hsa034202.82680826
11RNA transport_Homo sapiens_hsa030132.69847000
12Pyrimidine metabolism_Homo sapiens_hsa002402.69841459
13One carbon pool by folate_Homo sapiens_hsa006702.45750014
14Cell cycle_Homo sapiens_hsa041102.21189259
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19489581
16* Fanconi anemia pathway_Homo sapiens_hsa034602.18347177
17Propanoate metabolism_Homo sapiens_hsa006402.15425592
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13246932
19RNA degradation_Homo sapiens_hsa030182.10858039
20Protein export_Homo sapiens_hsa030601.92808993
21Non-homologous end-joining_Homo sapiens_hsa034501.82235240
22Basal transcription factors_Homo sapiens_hsa030221.71481009
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66130801
24Purine metabolism_Homo sapiens_hsa002301.60887553
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60855842
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54331944
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48428580
28Fatty acid elongation_Homo sapiens_hsa000621.45993358
29Pyruvate metabolism_Homo sapiens_hsa006201.44306790
30Steroid biosynthesis_Homo sapiens_hsa001001.30759649
31mRNA surveillance pathway_Homo sapiens_hsa030151.30240568
32Butanoate metabolism_Homo sapiens_hsa006501.29227029
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29004853
34Parkinsons disease_Homo sapiens_hsa050121.25977464
35Systemic lupus erythematosus_Homo sapiens_hsa053221.23063559
36p53 signaling pathway_Homo sapiens_hsa041151.17547816
37Folate biosynthesis_Homo sapiens_hsa007901.17173383
38Antigen processing and presentation_Homo sapiens_hsa046121.12831994
39Huntingtons disease_Homo sapiens_hsa050161.08494658
40Oxidative phosphorylation_Homo sapiens_hsa001901.06959485
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.06427786
42Vitamin B6 metabolism_Homo sapiens_hsa007501.04660771
43Primary immunodeficiency_Homo sapiens_hsa053401.04494757
44Epstein-Barr virus infection_Homo sapiens_hsa051691.02086910
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94399893
46Phototransduction_Homo sapiens_hsa047440.92090711
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.89738683
48Herpes simplex infection_Homo sapiens_hsa051680.87256288
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77926868
50Peroxisome_Homo sapiens_hsa041460.77431836
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75554095
52Fatty acid metabolism_Homo sapiens_hsa012120.71650979
53* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71214969
54Fatty acid degradation_Homo sapiens_hsa000710.70945122
55Allograft rejection_Homo sapiens_hsa053300.69578840
56Selenocompound metabolism_Homo sapiens_hsa004500.69523694
57Viral carcinogenesis_Homo sapiens_hsa052030.65566683
58Hedgehog signaling pathway_Homo sapiens_hsa043400.63139926
59Oocyte meiosis_Homo sapiens_hsa041140.62789411
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62234868
61Legionellosis_Homo sapiens_hsa051340.60413840
62beta-Alanine metabolism_Homo sapiens_hsa004100.59700785
63Tryptophan metabolism_Homo sapiens_hsa003800.58921216
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57528021
65Alzheimers disease_Homo sapiens_hsa050100.56808284
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55974847
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55652527
68Biosynthesis of amino acids_Homo sapiens_hsa012300.54826613
69Nicotine addiction_Homo sapiens_hsa050330.53546864
70Nitrogen metabolism_Homo sapiens_hsa009100.52967818
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.52915118
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52845198
73N-Glycan biosynthesis_Homo sapiens_hsa005100.52655705
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52557069
75Basal cell carcinoma_Homo sapiens_hsa052170.51523258
76Measles_Homo sapiens_hsa051620.51177962
77Cardiac muscle contraction_Homo sapiens_hsa042600.50573325
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49504593
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49473627
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.47723553
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47338726
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46496014
83Glutathione metabolism_Homo sapiens_hsa004800.45788774
84Hematopoietic cell lineage_Homo sapiens_hsa046400.44231497
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43396436
86Pentose phosphate pathway_Homo sapiens_hsa000300.42894749
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42764944
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.42738839
89TGF-beta signaling pathway_Homo sapiens_hsa043500.42026740
90Metabolic pathways_Homo sapiens_hsa011000.41700558
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41284922
92Asthma_Homo sapiens_hsa053100.41217270
93HTLV-I infection_Homo sapiens_hsa051660.40147920
94Sulfur relay system_Homo sapiens_hsa041220.39154186
95Thyroid cancer_Homo sapiens_hsa052160.38863686
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37870710
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.37439471
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.36345866
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36201264
100Alcoholism_Homo sapiens_hsa050340.36050666
101Fructose and mannose metabolism_Homo sapiens_hsa000510.34610025
102Viral myocarditis_Homo sapiens_hsa054160.34143038
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33829020
104Taste transduction_Homo sapiens_hsa047420.33499251
105Wnt signaling pathway_Homo sapiens_hsa043100.32715014
106Carbon metabolism_Homo sapiens_hsa012000.32307618
107Arachidonic acid metabolism_Homo sapiens_hsa005900.31264503
108Olfactory transduction_Homo sapiens_hsa047400.30969235
109Galactose metabolism_Homo sapiens_hsa000520.30886252
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30028542
111Vitamin digestion and absorption_Homo sapiens_hsa049770.29656106
112Tyrosine metabolism_Homo sapiens_hsa003500.29298571
113Hippo signaling pathway_Homo sapiens_hsa043900.28577032
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28548922
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27833692
116Lysine degradation_Homo sapiens_hsa003100.27288558
117Shigellosis_Homo sapiens_hsa051310.25870677
118Ether lipid metabolism_Homo sapiens_hsa005650.25707433
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.25356350
120Arginine and proline metabolism_Homo sapiens_hsa003300.25027481
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24985628
122Autoimmune thyroid disease_Homo sapiens_hsa053200.23298317
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22738768
124Fat digestion and absorption_Homo sapiens_hsa049750.22399582
125Apoptosis_Homo sapiens_hsa042100.21243051
126Linoleic acid metabolism_Homo sapiens_hsa005910.20624665
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18601147
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18199263
129Hepatitis B_Homo sapiens_hsa051610.18142790
130Circadian rhythm_Homo sapiens_hsa047100.17373110
131Graft-versus-host disease_Homo sapiens_hsa053320.16613828
132Influenza A_Homo sapiens_hsa051640.16573222
133Retinol metabolism_Homo sapiens_hsa008300.14188132
134Other glycan degradation_Homo sapiens_hsa005110.13002396
135Type I diabetes mellitus_Homo sapiens_hsa049400.12965373
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12405006
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.11782261
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.10770851
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.09356849
140Regulation of autophagy_Homo sapiens_hsa041400.09001932
141Caffeine metabolism_Homo sapiens_hsa002320.08874832
142Chemical carcinogenesis_Homo sapiens_hsa052040.07655350
143Notch signaling pathway_Homo sapiens_hsa043300.07225408

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »