FANCG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.02304348
2establishment of integrated proviral latency (GO:0075713)4.83665505
3telomere maintenance via semi-conservative replication (GO:0032201)4.80561598
4DNA strand elongation (GO:0022616)4.76609749
5DNA unwinding involved in DNA replication (GO:0006268)4.43454329
6DNA replication initiation (GO:0006270)4.43034976
7telomere maintenance via recombination (GO:0000722)4.31332793
8somatic hypermutation of immunoglobulin genes (GO:0016446)4.29705768
9somatic diversification of immune receptors via somatic mutation (GO:0002566)4.29705768
10mitotic recombination (GO:0006312)4.14583146
11heterochromatin organization (GO:0070828)4.03763525
12ribosomal small subunit assembly (GO:0000028)3.98178311
13protein localization to kinetochore (GO:0034501)3.95140774
14protein localization to chromosome, centromeric region (GO:0071459)3.91236358
15establishment of viral latency (GO:0019043)3.91144140
16DNA replication checkpoint (GO:0000076)3.87885920
17DNA deamination (GO:0045006)3.84212047
18DNA topological change (GO:0006265)3.82776269
19maturation of SSU-rRNA (GO:0030490)3.79525177
20translesion synthesis (GO:0019985)3.73570797
21DNA replication-dependent nucleosome organization (GO:0034723)3.68294564
22DNA replication-dependent nucleosome assembly (GO:0006335)3.68294564
23nucleotide-excision repair, DNA gap filling (GO:0006297)3.68197003
24DNA ligation (GO:0006266)3.61525552
25telomere maintenance via telomere lengthening (GO:0010833)3.61087943
26mitotic sister chromatid segregation (GO:0000070)3.58163852
27regulation of mitotic spindle organization (GO:0060236)3.49243330
28positive regulation of chromosome segregation (GO:0051984)3.48615878
29regulation of translational fidelity (GO:0006450)3.47706720
30pore complex assembly (GO:0046931)3.45418106
31piRNA metabolic process (GO:0034587)3.43996789
32chromatin remodeling at centromere (GO:0031055)3.41652364
33mitotic chromosome condensation (GO:0007076)3.41051666
34ribosome assembly (GO:0042255)3.39750896
35mitotic nuclear envelope disassembly (GO:0007077)3.38691516
36DNA replication-independent nucleosome organization (GO:0034724)3.35418093
37DNA replication-independent nucleosome assembly (GO:0006336)3.35418093
38regulation of sister chromatid cohesion (GO:0007063)3.33773430
39CENP-A containing nucleosome assembly (GO:0034080)3.33514163
40maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.28238600
41viral mRNA export from host cell nucleus (GO:0046784)3.27433813
42spliceosomal tri-snRNP complex assembly (GO:0000244)3.26168923
43protein complex localization (GO:0031503)3.26063087
44regulation of mammary gland epithelial cell proliferation (GO:0033599)3.23925618
45postreplication repair (GO:0006301)3.20476044
46sister chromatid segregation (GO:0000819)3.20453597
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20321521
48meiotic chromosome segregation (GO:0045132)3.19976395
49spindle checkpoint (GO:0031577)3.19552010
50regulation of histone H3-K9 methylation (GO:0051570)3.18583015
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.16428238
52negative regulation of sister chromatid segregation (GO:0033046)3.16428238
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16428238
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16428238
55negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16428238
56nuclear envelope organization (GO:0006998)3.16378643
57histone exchange (GO:0043486)3.15318159
58peptidyl-arginine omega-N-methylation (GO:0035247)3.14408631
59mitotic spindle assembly checkpoint (GO:0007094)3.13282334
60mitotic sister chromatid cohesion (GO:0007064)3.12144806
61kinetochore organization (GO:0051383)3.10087288
62L-serine metabolic process (GO:0006563)3.10020224
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09463466
64nuclear envelope disassembly (GO:0051081)3.08366651
65membrane disassembly (GO:0030397)3.08366651
66DNA duplex unwinding (GO:0032508)3.08083728
67mitotic spindle checkpoint (GO:0071174)3.07963305
68chromatin assembly (GO:0031497)3.07946604
69DNA geometric change (GO:0032392)3.07816570
70regulation of nuclear cell cycle DNA replication (GO:0033262)3.07794929
71negative regulation of mRNA processing (GO:0050686)3.07639866
72spindle assembly checkpoint (GO:0071173)3.07001383
73nucleobase-containing small molecule interconversion (GO:0015949)3.06368595
74attachment of spindle microtubules to kinetochore (GO:0008608)3.04672369
75IMP biosynthetic process (GO:0006188)3.03714301
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02428630
77regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02428630
78DNA strand renaturation (GO:0000733)3.02189150
79regulation of sister chromatid segregation (GO:0033045)3.00435927
80regulation of mitotic sister chromatid separation (GO:0010965)3.00435927
81regulation of mitotic sister chromatid segregation (GO:0033047)3.00435927
82mismatch repair (GO:0006298)2.97762148
83protein-DNA complex disassembly (GO:0032986)2.95896519
84nucleosome disassembly (GO:0006337)2.95896519
85non-recombinational repair (GO:0000726)2.95188533
86double-strand break repair via nonhomologous end joining (GO:0006303)2.95188533
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94083108
88nuclear pore complex assembly (GO:0051292)2.93776613
89mitotic cell cycle (GO:0000278)2.93712674
90folic acid metabolic process (GO:0046655)2.93446340
91replication fork processing (GO:0031297)2.93096493
92nucleobase biosynthetic process (GO:0046112)2.92756114
93chromatin assembly or disassembly (GO:0006333)2.92256739
94nuclear pore organization (GO:0006999)2.91719274
95rRNA transcription (GO:0009303)2.91489071
96telomere maintenance (GO:0000723)2.90989982
97cilium or flagellum-dependent cell motility (GO:0001539)2.90488599
98DNA conformation change (GO:0071103)2.90265855
99telomere organization (GO:0032200)2.90261569
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86821373
101microtubule depolymerization (GO:0007019)2.86496366
102IMP metabolic process (GO:0046040)2.85549170
103intra-S DNA damage checkpoint (GO:0031573)2.85242291
104fusion of sperm to egg plasma membrane (GO:0007342)2.84134311
105base-excision repair (GO:0006284)2.84076669
106regulation of centriole replication (GO:0046599)2.82298939
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81486148
108viral transcription (GO:0019083)2.81371928
109mitotic metaphase plate congression (GO:0007080)2.81267592
110chromosome condensation (GO:0030261)2.81012286
111chromosome segregation (GO:0007059)2.78633510
112formation of translation preinitiation complex (GO:0001731)2.75637250
113protein localization to chromosome (GO:0034502)2.75390068
114histone H2A acetylation (GO:0043968)2.75245368
115translational elongation (GO:0006414)2.74959906
116DNA packaging (GO:0006323)2.74280627
117mitotic G1 DNA damage checkpoint (GO:0031571)2.72965982
118translational termination (GO:0006415)2.72542869
119regulation of chromosome segregation (GO:0051983)2.70725519
120binding of sperm to zona pellucida (GO:0007339)2.70452557
121regulation of double-strand break repair via homologous recombination (GO:0010569)2.69349248
122folic acid-containing compound biosynthetic process (GO:0009396)2.68246091
123DNA replication (GO:0006260)2.66965005
124regulation of spindle checkpoint (GO:0090231)2.65138005
125kinetochore assembly (GO:0051382)2.64668304
126regulation of centrosome cycle (GO:0046605)2.63911180
127negative regulation of RNA splicing (GO:0033119)2.62684643
128regulation of spindle organization (GO:0090224)2.62075699
129regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.61728743
130meiotic nuclear division (GO:0007126)2.61588988
131establishment of chromosome localization (GO:0051303)2.61093399
132sperm-egg recognition (GO:0035036)2.60240559
133DNA biosynthetic process (GO:0071897)2.60190387
134male meiosis (GO:0007140)2.59443525
135termination of RNA polymerase II transcription (GO:0006369)2.58128922
136synaptonemal complex assembly (GO:0007130)2.55708191
137chromosome organization (GO:0051276)2.55610095
138metaphase plate congression (GO:0051310)2.55097719
139DNA methylation involved in gamete generation (GO:0043046)2.55092164
140purine nucleobase biosynthetic process (GO:0009113)2.54591782
141resolution of meiotic recombination intermediates (GO:0000712)2.54438998
142regulation of helicase activity (GO:0051095)2.53709327
143negative regulation of chromosome segregation (GO:0051985)2.53252495
144ATP-dependent chromatin remodeling (GO:0043044)2.52496499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.27070390
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.86285668
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.79958941
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48148616
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30594169
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.09634186
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84025037
8MYC_22102868_ChIP-Seq_BL_Human2.37318968
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31001858
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28392353
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24899717
12* EST1_17652178_ChIP-ChIP_JURKAT_Human2.23183590
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17430347
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14621256
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13866423
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.06643991
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04774462
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.99834822
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98483432
20VDR_21846776_ChIP-Seq_THP-1_Human1.93464440
21XRN2_22483619_ChIP-Seq_HELA_Human1.88774284
22VDR_23849224_ChIP-Seq_CD4+_Human1.87758038
23* E2F1_21310950_ChIP-Seq_MCF-7_Human1.87580777
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83968750
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81802422
26FOXP3_21729870_ChIP-Seq_TREG_Human1.81144324
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78819871
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78374039
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77515040
30CIITA_25753668_ChIP-Seq_RAJI_Human1.75427939
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.74486422
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73096894
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72108918
34AR_21909140_ChIP-Seq_LNCAP_Human1.69927384
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69290345
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68026341
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67056012
38GABP_19822575_ChIP-Seq_HepG2_Human1.60047727
39* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59488831
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57690399
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55173761
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54925315
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53909089
44DCP1A_22483619_ChIP-Seq_HELA_Human1.51768603
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49642661
46* SPI1_23547873_ChIP-Seq_NB4_Human1.48302353
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47546578
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46639716
49TTF2_22483619_ChIP-Seq_HELA_Human1.43897581
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41918926
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41742974
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34314735
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34288253
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33752594
55ZNF263_19887448_ChIP-Seq_K562_Human1.33396956
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32126611
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.31906634
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.31182365
59KDM5A_27292631_Chip-Seq_BREAST_Human1.29401018
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27980609
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.27621064
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27254007
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.24195835
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23316705
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22844419
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22734618
67SCL_19346495_ChIP-Seq_HPC-7_Human1.22577722
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22080199
69* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21814230
70MAF_26560356_Chip-Seq_TH1_Human1.21760517
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21178163
72MYB_26560356_Chip-Seq_TH1_Human1.20769221
73MYB_26560356_Chip-Seq_TH2_Human1.20681382
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19127052
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18362164
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16471647
77UTX_26944678_Chip-Seq_JUKART_Human1.16468947
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.15641834
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15410373
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15258591
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14550115
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14462608
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13947897
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13741998
85* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13213372
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13062922
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11035647
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09938644
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09903983
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08560916
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.06790024
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06498018
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06371503
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04322344
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03849871
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03487871
97TCF7_22412390_ChIP-Seq_EML_Mouse1.02029572
98VDR_24763502_ChIP-Seq_THP-1_Human1.00641639
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99921910
100TFEB_21752829_ChIP-Seq_HELA_Human0.99832702
101MAF_26560356_Chip-Seq_TH2_Human0.98062336
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98020656
103PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97390849
104ELK1_19687146_ChIP-ChIP_HELA_Human0.96457125
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.96081643
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94641654
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94614806
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93032414
109RACK7_27058665_Chip-Seq_MCF-7_Human0.91808905
110* NANOG_21062744_ChIP-ChIP_HESCs_Human0.90681891
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90515222
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90456985
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89734662
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88906176
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88519531
116* FOXP1_21924763_ChIP-Seq_HESCs_Human0.88362680
117ATF3_27146783_Chip-Seq_COLON_Human0.87907034
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87307812
119CHD1_26751641_Chip-Seq_LNCaP_Human0.87113480
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86838774
121* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86245026
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86087183
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85317586
124TET1_21451524_ChIP-Seq_MESCs_Mouse0.85252127
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84980598
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84844755
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84542298
128SOX17_20123909_ChIP-Seq_XEN_Mouse0.83361318
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83219580
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81712379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.62105212
2* MP0010094_abnormal_chromosome_stability4.32519321
3MP0003111_abnormal_nucleus_morphology3.93305056
4MP0003693_abnormal_embryo_hatching3.84942751
5MP0008877_abnormal_DNA_methylation3.59698473
6MP0002396_abnormal_hematopoietic_system3.53978167
7MP0003077_abnormal_cell_cycle3.29505459
8MP0008058_abnormal_DNA_repair3.25454346
9MP0004957_abnormal_blastocyst_morpholog3.16067089
10MP0005410_abnormal_fertilization2.69766955
11MP0008007_abnormal_cellular_replicative2.65612958
12MP0010030_abnormal_orbit_morphology2.48840921
13MP0004808_abnormal_hematopoietic_stem2.33239315
14MP0001835_abnormal_antigen_presentation2.31240442
15MP0003763_abnormal_thymus_physiology2.27398911
16MP0010307_abnormal_tumor_latency2.21001777
17MP0002398_abnormal_bone_marrow2.14941333
18MP0001545_abnormal_hematopoietic_system2.10406471
19MP0005397_hematopoietic_system_phenotyp2.10406471
20MP0003705_abnormal_hypodermis_morpholog1.98254881
21MP0000490_abnormal_crypts_of1.89861854
22MP0005671_abnormal_response_to1.86519316
23* MP0001929_abnormal_gametogenesis1.85432058
24MP0002877_abnormal_melanocyte_morpholog1.80100524
25MP0000689_abnormal_spleen_morphology1.79649321
26MP0001800_abnormal_humoral_immune1.79375397
27MP0001730_embryonic_growth_arrest1.77569524
28MP0009672_abnormal_birth_weight1.76763503
29MP0000685_abnormal_immune_system1.76278817
30MP0002722_abnormal_immune_system1.75006731
31MP0000350_abnormal_cell_proliferation1.74852588
32MP0000703_abnormal_thymus_morphology1.71890245
33MP0003786_premature_aging1.68054312
34MP0002420_abnormal_adaptive_immunity1.64763032
35MP0000716_abnormal_immune_system1.64607558
36MP0002019_abnormal_tumor_incidence1.64503184
37MP0009333_abnormal_splenocyte_physiolog1.64007224
38MP0005174_abnormal_tail_pigmentation1.63941372
39MP0001819_abnormal_immune_cell1.61521918
40MP0002429_abnormal_blood_cell1.61054384
41* MP0002210_abnormal_sex_determination1.58519347
42MP0002452_abnormal_antigen_presenting1.53646207
43MP0000313_abnormal_cell_death1.53126199
44MP0005257_abnormal_intraocular_pressure1.51373629
45MP0004233_abnormal_muscle_weight1.49866962
46* MP0003698_abnormal_male_reproductive1.48707325
47MP0008932_abnormal_embryonic_tissue1.48598534
48MP0002723_abnormal_immune_serum1.48498125
49MP0009697_abnormal_copulation1.46674793
50MP0002697_abnormal_eye_size1.45719115
51* MP0001145_abnormal_male_reproductive1.44473520
52MP0009278_abnormal_bone_marrow1.44117645
53MP0010352_gastrointestinal_tract_polyps1.43193178
54MP0002166_altered_tumor_susceptibility1.39207490
55MP0005501_abnormal_skin_physiology1.37127046
56MP0005075_abnormal_melanosome_morpholog1.35829753
57MP0003436_decreased_susceptibility_to1.35788747
58MP0005000_abnormal_immune_tolerance1.34967551
59MP0005025_abnormal_response_to1.33396630
60MP0003315_abnormal_perineum_morphology1.32591210
61MP0001346_abnormal_lacrimal_gland1.32084018
62MP0002405_respiratory_system_inflammati1.31937076
63MP0009785_altered_susceptibility_to1.31920842
64MP0001873_stomach_inflammation1.31823085
65MP0001849_ear_inflammation1.29384304
66MP0004185_abnormal_adipocyte_glucose1.27627710
67MP0001697_abnormal_embryo_size1.27312137
68MP0000015_abnormal_ear_pigmentation1.23917032
69MP0003718_maternal_effect1.20813716
70MP0001790_abnormal_immune_system1.20772735
71MP0005387_immune_system_phenotype1.20772735
72MP0002080_prenatal_lethality1.18440790
73MP0004264_abnormal_extraembryonic_tissu1.17864512
74MP0005464_abnormal_platelet_physiology1.17123262
75MP0003303_peritoneal_inflammation1.16742161
76MP0001672_abnormal_embryogenesis/_devel1.16556602
77MP0005380_embryogenesis_phenotype1.16556602
78* MP0000653_abnormal_sex_gland1.16009204
79MP0003937_abnormal_limbs/digits/tail_de1.15168289
80MP0003123_paternal_imprinting1.14906868
81MP0002419_abnormal_innate_immunity1.12670519
82MP0002111_abnormal_tail_morphology1.11573777
83MP0003984_embryonic_growth_retardation1.10907343
84MP0000465_gastrointestinal_hemorrhage1.06808141
85MP0001293_anophthalmia1.05917561
86MP0002088_abnormal_embryonic_growth/wei1.05503839
87MP0002006_tumorigenesis1.05014884
88MP0005451_abnormal_body_composition1.04777384
89MP0000537_abnormal_urethra_morphology1.04288954
90MP0005076_abnormal_cell_differentiation1.03535177
91MP0008260_abnormal_autophagy1.02404556
92MP0002086_abnormal_extraembryonic_tissu1.02201415
93MP0010155_abnormal_intestine_physiology1.01984669
94MP0002653_abnormal_ependyma_morphology1.01972880
95MP0000358_abnormal_cell_content/1.01878751
96MP0003866_abnormal_defecation1.00786711
97MP0002095_abnormal_skin_pigmentation1.00337521
98MP0003385_abnormal_body_wall0.99052081
99MP0003941_abnormal_skin_development0.99047826
100MP0000428_abnormal_craniofacial_morphol0.97696613
101MP0006035_abnormal_mitochondrial_morpho0.97143575
102MP0002163_abnormal_gland_morphology0.95977786
103MP0001661_extended_life_span0.95474761
104MP0004858_abnormal_nervous_system0.95349519
105MP0002092_abnormal_eye_morphology0.93355839
106MP0000858_altered_metastatic_potential0.93055279
107MP0000579_abnormal_nail_morphology0.92652178
108MP0002148_abnormal_hypersensitivity_rea0.91522613
109* MP0002161_abnormal_fertility/fecundity0.90430770
110MP0002089_abnormal_postnatal_growth/wei0.89499545
111MP0003172_abnormal_lysosome_physiology0.89231432
112MP0009703_decreased_birth_body0.87791986
113MP0003656_abnormal_erythrocyte_physiolo0.87778660
114MP0003566_abnormal_cell_adhesion0.86468054
115MP0002085_abnormal_embryonic_tissue0.84936233
116MP0002796_impaired_skin_barrier0.84672381
117MP0001853_heart_inflammation0.83696998
118MP0001845_abnormal_inflammatory_respons0.83565159
119MP0002009_preneoplasia0.83268999
120MP0003115_abnormal_respiratory_system0.81848768
121MP0005384_cellular_phenotype0.80752220
122MP0001286_abnormal_eye_development0.80751397
123MP0005621_abnormal_cell_physiology0.80057804
124MP0002084_abnormal_developmental_patter0.79790509
125MP0003942_abnormal_urinary_system0.79411679
126MP0000733_abnormal_muscle_development0.78896719
127MP0003806_abnormal_nucleotide_metabolis0.78760161
128MP0008995_early_reproductive_senescence0.78204881
129MP0010234_abnormal_vibrissa_follicle0.76564174
130MP0002060_abnormal_skin_morphology0.73269119
131MP0003861_abnormal_nervous_system0.72884172
132MP0005171_absent_coat_pigmentation0.72843485
133MP0003221_abnormal_cardiomyocyte_apopto0.69943769
134MP0000003_abnormal_adipose_tissue0.69842731
135MP0009053_abnormal_anal_canal0.69235853
136MP0000566_synostosis0.68067528
137MP0002938_white_spotting0.67439558
138MP0006292_abnormal_olfactory_placode0.66889086
139MP0005623_abnormal_meninges_morphology0.66428403
140MP0003935_abnormal_craniofacial_develop0.65977433
141MP0004197_abnormal_fetal_growth/weight/0.65784700
142MP0000762_abnormal_tongue_morphology0.65513546
143MP0003943_abnormal_hepatobiliary_system0.65013173
144MP0000049_abnormal_middle_ear0.64793459
145MP0003755_abnormal_palate_morphology0.64592682
146MP0006054_spinal_hemorrhage0.64045563
147MP0001881_abnormal_mammary_gland0.63743298
148MP0004147_increased_porphyrin_level0.62862743
149MP0003567_abnormal_fetal_cardiomyocyte0.62483759
150MP0002114_abnormal_axial_skeleton0.61985145
151MP0003121_genomic_imprinting0.61281759
152MP0004947_skin_inflammation0.60300580
153MP0002160_abnormal_reproductive_system0.59570368
154MP0001243_abnormal_dermal_layer0.59483774
155MP0005220_abnormal_exocrine_pancreas0.59434937
156MP0002083_premature_death0.58021076
157MP0000477_abnormal_intestine_morphology0.57535894

Predicted human phenotypes

RankGene SetZ-score
1Agnosia (HP:0010524)3.71754595
211 pairs of ribs (HP:0000878)3.69475603
3Degeneration of anterior horn cells (HP:0002398)3.68367882
4Abnormality of the anterior horn cell (HP:0006802)3.68367882
5Thrombocytosis (HP:0001894)3.59158979
6Selective tooth agenesis (HP:0001592)3.54464128
7Chromsome breakage (HP:0040012)3.49553990
8IgM deficiency (HP:0002850)3.47820645
9Abnormality of cells of the erythroid lineage (HP:0012130)3.43049818
10Abnormal number of erythroid precursors (HP:0012131)3.41930530
11Colon cancer (HP:0003003)3.38345734
12Nasal polyposis (HP:0100582)3.32313310
13Reticulocytopenia (HP:0001896)3.32122705
14Recurrent bronchitis (HP:0002837)3.26521851
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.23300726
16Microvesicular hepatic steatosis (HP:0001414)3.11537231
17* Abnormality of the preputium (HP:0100587)3.09786280
18Birth length less than 3rd percentile (HP:0003561)3.08767900
19* Myelodysplasia (HP:0002863)3.06721380
20* Abnormality of chromosome stability (HP:0003220)3.04612569
21* Aplasia/Hypoplasia of the uvula (HP:0010293)2.97779028
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.96208125
23Abnormality of the nasal mucosa (HP:0000433)2.89655051
24* Abnormality of the ileum (HP:0001549)2.87945101
25Basal cell carcinoma (HP:0002671)2.85577943
26* Meckel diverticulum (HP:0002245)2.83027422
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72586928
28Absent thumb (HP:0009777)2.70460049
29Proximal placement of thumb (HP:0009623)2.69680260
30Impulsivity (HP:0100710)2.65395092
31Deviation of the thumb (HP:0009603)2.61993931
32Progressive muscle weakness (HP:0003323)2.61455748
33High anterior hairline (HP:0009890)2.60698742
34Bronchitis (HP:0012387)2.58484356
35* Bone marrow hypocellularity (HP:0005528)2.58064437
36Poikiloderma (HP:0001029)2.57705419
37High pitched voice (HP:0001620)2.54303395
38Ependymoma (HP:0002888)2.53895557
39Nephroblastoma (Wilms tumor) (HP:0002667)2.45931883
40Prominent nose (HP:0000448)2.45894690
41Lymphoma (HP:0002665)2.44962933
42Recurrent sinusitis (HP:0011108)2.43869909
43Acute lymphatic leukemia (HP:0006721)2.41062699
44Chronic otitis media (HP:0000389)2.40391634
45Squamous cell carcinoma (HP:0002860)2.39892825
46Hypoplasia of the capital femoral epiphysis (HP:0003090)2.38668195
47Amaurosis fugax (HP:0100576)2.37749835
48Volvulus (HP:0002580)2.36790413
49Recurrent viral infections (HP:0004429)2.36785615
50* Sloping forehead (HP:0000340)2.34961998
51Elevated erythrocyte sedimentation rate (HP:0003565)2.34749952
52Atrophy/Degeneration involving motor neurons (HP:0007373)2.34466776
53Absent radius (HP:0003974)2.32809789
54* Abnormality of the carotid arteries (HP:0005344)2.32427142
55* Clubbing of toes (HP:0100760)2.31973252
56Medulloblastoma (HP:0002885)2.31869807
57* Small intestinal stenosis (HP:0012848)2.30973666
58* Duodenal stenosis (HP:0100867)2.30973666
59Broad distal phalanx of finger (HP:0009836)2.26492359
60Aplastic anemia (HP:0001915)2.25635846
61Recurrent abscess formation (HP:0002722)2.24905130
62Oral leukoplakia (HP:0002745)2.24553364
63Multiple enchondromatosis (HP:0005701)2.24060379
64Abnormality of T cell physiology (HP:0011840)2.23119944
65Acute myeloid leukemia (HP:0004808)2.23044934
66Embryonal renal neoplasm (HP:0011794)2.21766841
67Abnormality of T cells (HP:0002843)2.21445711
68Abnormal number of incisors (HP:0011064)2.21180251
69Entropion (HP:0000621)2.18730092
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.18707935
71Absent/shortened dynein arms (HP:0200106)2.18707935
72Increased nuchal translucency (HP:0010880)2.17439513
73Absent forearm bone (HP:0003953)2.16115316
74Aplasia involving forearm bones (HP:0009822)2.16115316
75Cortical dysplasia (HP:0002539)2.15697070
76Ectopic kidney (HP:0000086)2.15584658
77Hypoplastic pelvis (HP:0008839)2.14731983
78Abnormal lung lobation (HP:0002101)2.14157823
79Pulmonary fibrosis (HP:0002206)2.11188392
80B lymphocytopenia (HP:0010976)2.10827223
81Abnormality of B cell number (HP:0010975)2.10827223
82* Leukopenia (HP:0001882)2.10509712
83Aplasia/Hypoplasia of the patella (HP:0006498)2.10050933
84Recurrent otitis media (HP:0000403)2.09920706
85Pancytopenia (HP:0001876)2.09654082
86Insomnia (HP:0100785)2.09379608
87Petechiae (HP:0000967)2.08964611
88Abnormality of the lower motor neuron (HP:0002366)2.08957691
89Rough bone trabeculation (HP:0100670)2.08315967
90Ulnar bowing (HP:0003031)2.08236595
91Myositis (HP:0100614)2.08199408
92Horseshoe kidney (HP:0000085)2.07995996
93Combined immunodeficiency (HP:0005387)2.07286075
94Pallor (HP:0000980)2.06712597
95Missing ribs (HP:0000921)2.04608855
96Abnormality of cells of the lymphoid lineage (HP:0012140)2.04036619
97Abnormality of the fingertips (HP:0001211)2.03033898
98Lymphopenia (HP:0001888)2.02898672
99Abnormality of cochlea (HP:0000375)2.02297437
100Asplenia (HP:0001746)2.02124844
101Cutaneous melanoma (HP:0012056)2.02038979
102Microglossia (HP:0000171)2.00836158
103Patellar aplasia (HP:0006443)2.00192038
104Abnormality of the prostate (HP:0008775)2.00167222
105Secondary amenorrhea (HP:0000869)2.00040449
106Homocystinuria (HP:0002156)1.98635532
107Abnormality of homocysteine metabolism (HP:0010919)1.98635532
108Recurrent fungal infections (HP:0002841)1.98553701
109Upper motor neuron abnormality (HP:0002127)1.97820709
110* Tracheoesophageal fistula (HP:0002575)1.97031483
111Rhinitis (HP:0012384)1.96351388
112Chronic obstructive pulmonary disease (HP:0006510)1.95922230
113Obstructive lung disease (HP:0006536)1.95922230
114Short thumb (HP:0009778)1.95861347
115Spastic diplegia (HP:0001264)1.95695546
116Abnormality of DNA repair (HP:0003254)1.95260531
117Duplication of thumb phalanx (HP:0009942)1.93924973
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93129132
119Trismus (HP:0000211)1.92947916
120Cellulitis (HP:0100658)1.92292461
121Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89963062
122Absent epiphyses (HP:0010577)1.89963062
123IgG deficiency (HP:0004315)1.89670393
124* Abnormality of the duodenum (HP:0002246)1.89213759
125Astrocytoma (HP:0009592)1.87824975
126Abnormality of the astrocytes (HP:0100707)1.87824975
127Abnormality of the umbilical cord (HP:0010881)1.87586349
128Abnormal spermatogenesis (HP:0008669)1.86767955
129Abnormal respiratory motile cilium morphology (HP:0005938)1.86145636
130Abnormal respiratory epithelium morphology (HP:0012253)1.86145636
131Breast hypoplasia (HP:0003187)1.86073265
132Atresia of the external auditory canal (HP:0000413)1.85822818
133Testicular atrophy (HP:0000029)1.85495950
134Bronchiectasis (HP:0002110)1.85475636
135Cerebral hypomyelination (HP:0006808)1.85191936
136Shoulder girdle muscle weakness (HP:0003547)1.83935372
137* Cafe-au-lait spot (HP:0000957)1.82005721
138Abnormal gallbladder physiology (HP:0012438)1.81736878
139Cholecystitis (HP:0001082)1.81736878
140Spinal muscular atrophy (HP:0007269)1.81633492
141Facial hemangioma (HP:0000329)1.80929580
142Premature graying of hair (HP:0002216)1.79766189
143Aplasia/Hypoplasia of the spleen (HP:0010451)1.79572225
144Neoplasm of the pancreas (HP:0002894)1.78864727
145Panhypogammaglobulinemia (HP:0003139)1.78731605
146Hyperacusis (HP:0010780)1.78633460
147Long palpebral fissure (HP:0000637)1.77207500
148Progressive external ophthalmoplegia (HP:0000590)1.76237913
149Facial cleft (HP:0002006)1.74088143
150Pointed chin (HP:0000307)1.71438538
151Abnormality of reticulocytes (HP:0004312)1.71104064
152Overriding aorta (HP:0002623)1.70744033
153Glioma (HP:0009733)1.69800592
154Renal cell carcinoma (HP:0005584)1.68718062
155Urethral obstruction (HP:0000796)1.67888825
156* Choanal atresia (HP:0000453)1.67644362
157Abnormality of pyrimidine metabolism (HP:0004353)1.67596520
158Pelvic girdle muscle weakness (HP:0003749)1.67009076
159Glossoptosis (HP:0000162)1.66067040
160Abnormal trabecular bone morphology (HP:0100671)1.61506374
161Abnormality of the calcaneus (HP:0008364)1.61316893
162Deep philtrum (HP:0002002)1.61053634
163Aplasia/Hypoplasia of the breasts (HP:0010311)1.58180195
164Pseudobulbar signs (HP:0002200)1.56412308
165Carpal bone hypoplasia (HP:0001498)1.55677788
166Rhabdomyosarcoma (HP:0002859)1.55664844
167Abnormality of methionine metabolism (HP:0010901)1.53349471
168Overlapping toe (HP:0001845)1.53340170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.20131328
2VRK23.57643485
3WEE13.46378069
4NEK23.24682086
5SMG13.13466021
6BUB12.93150181
7MAP4K12.87139316
8CCNB12.74029475
9STK162.55856068
10EEF2K2.52543304
11PDK32.32879993
12PDK42.32879993
13PBK2.23408169
14ZAK2.19624230
15ACVR1B2.14097984
16TRIB32.10167779
17EIF2AK11.94641801
18TESK21.85694677
19STK101.76024883
20TTK1.70941295
21KIT1.68458621
22ATR1.65306290
23TAF11.62307589
24TESK11.55129629
25PASK1.53498120
26VRK11.50921383
27STK41.50560722
28PLK11.50349495
29CDK41.49170928
30EIF2AK31.48057245
31MAP3K101.43585330
32TSSK61.42783643
33NEK11.40955222
34BRSK21.40673305
35EPHA21.39615491
36CSF1R1.39184124
37MST1R1.37422257
38RPS6KB21.35514633
39IRAK31.32710949
40CDK71.32692164
41PNCK1.31172510
42FLT31.24737175
43AURKB1.23550453
44NME21.21102516
45BTK1.20779635
46TGFBR11.17072386
47DAPK11.16556086
48CHEK11.16205704
49CHEK21.15064241
50PIM11.10560325
51DYRK31.07184375
52ZAP701.07111667
53TYK21.04471795
54PIM21.04442342
55PLK41.03982915
56CDK121.03587021
57LRRK21.02397335
58SRPK11.02237715
59NME10.99689411
60TEC0.97251044
61PDK20.97232451
62SCYL20.96976636
63GRK60.95842196
64BRSK10.95350175
65SYK0.93466700
66PRPF4B0.92335935
67MAP3K80.92085072
68SIK10.91660409
69YES10.91516169
70EIF2AK20.91339815
71TXK0.89880282
72MAPKAPK30.88363527
73PKN20.87211987
74ICK0.86362952
75TLK10.84926275
76SIK20.80019005
77MAP2K30.79814336
78CLK10.78408510
79ATM0.77622007
80PRKD30.77336690
81PAK40.75405587
82CDK20.73741510
83BRAF0.69948025
84JAK30.69628174
85MKNK10.68376353
86CDK190.67284354
87AURKA0.67107719
88LYN0.66401133
89CDK60.66148090
90CDK90.65859616
91LCK0.65233697
92MET0.65189418
93MATK0.62378627
94MELK0.61751647
95RPS6KA40.59740597
96MTOR0.59738652
97FES0.59431567
98PLK30.58459276
99BLK0.56723874
100BRD40.55952385
101KDR0.55733980
102HCK0.55421213
103CDK11A0.53908107
104AKT20.53536649
105CDK150.53199999
106CDK180.51409296
107TAOK10.46666250
108PAK10.45843390
109ERBB40.45588593
110TRPM70.45391703
111ALK0.45079809
112MAP3K60.43087102
113ITK0.42476422
114BMX0.42382847
115CDK140.42333695
116* CDK10.41995257
117MAPK110.41684068
118IRAK20.39800850
119CSNK2A10.37856901
120PDGFRA0.37369788
121RAF10.37329742
122PRKCI0.37091412
123CSNK1G30.36219604
124TAOK20.35969245
125CSNK2A20.34782936
126TBK10.34745026
127ARAF0.34551739
128LATS20.34448078
129TTN0.33036921
130MKNK20.32327288
131PTK20.32129540
132IRAK40.31965124
133STK30.30855389
134ERN10.30341855
135CSNK1A1L0.29528234
136FGFR40.29009840
137CDK80.28709178
138MAP3K110.28637606
139PRKDC0.26895990

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.70314814
2Mismatch repair_Homo sapiens_hsa034304.63043511
3Base excision repair_Homo sapiens_hsa034103.91046596
4Homologous recombination_Homo sapiens_hsa034403.52936383
5Spliceosome_Homo sapiens_hsa030402.78675098
6* Fanconi anemia pathway_Homo sapiens_hsa034602.73272962
7Nucleotide excision repair_Homo sapiens_hsa034202.68806401
8Non-homologous end-joining_Homo sapiens_hsa034502.65275589
9Cell cycle_Homo sapiens_hsa041102.57605532
10Ribosome_Homo sapiens_hsa030102.53462206
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49371990
12RNA transport_Homo sapiens_hsa030132.47757880
13Pyrimidine metabolism_Homo sapiens_hsa002402.12182263
14One carbon pool by folate_Homo sapiens_hsa006702.01332667
15RNA polymerase_Homo sapiens_hsa030201.98732870
16Proteasome_Homo sapiens_hsa030501.93774677
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84833627
18Primary immunodeficiency_Homo sapiens_hsa053401.83528547
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75629642
20mRNA surveillance pathway_Homo sapiens_hsa030151.57968325
21RNA degradation_Homo sapiens_hsa030181.49279028
22p53 signaling pathway_Homo sapiens_hsa041151.45629778
23Basal transcription factors_Homo sapiens_hsa030221.44098621
24Antigen processing and presentation_Homo sapiens_hsa046121.34178048
25Pentose phosphate pathway_Homo sapiens_hsa000301.28003470
26Herpes simplex infection_Homo sapiens_hsa051681.24912098
27Folate biosynthesis_Homo sapiens_hsa007901.22028439
28Epstein-Barr virus infection_Homo sapiens_hsa051691.19274095
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18536421
30Purine metabolism_Homo sapiens_hsa002301.17068909
31B cell receptor signaling pathway_Homo sapiens_hsa046621.09800925
32Oocyte meiosis_Homo sapiens_hsa041141.05172857
33Hematopoietic cell lineage_Homo sapiens_hsa046400.99836200
34Measles_Homo sapiens_hsa051620.98176632
35Systemic lupus erythematosus_Homo sapiens_hsa053220.97825180
36Legionellosis_Homo sapiens_hsa051340.94626504
37Bladder cancer_Homo sapiens_hsa052190.94184818
38Viral carcinogenesis_Homo sapiens_hsa052030.92820863
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90565728
40Lysine degradation_Homo sapiens_hsa003100.88953785
41Pyruvate metabolism_Homo sapiens_hsa006200.87276096
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87232410
43HTLV-I infection_Homo sapiens_hsa051660.84650655
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.84492844
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83299051
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.82952921
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78461616
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77858230
49Galactose metabolism_Homo sapiens_hsa000520.76359049
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73369333
51Shigellosis_Homo sapiens_hsa051310.72931319
52Basal cell carcinoma_Homo sapiens_hsa052170.72229326
53Glutathione metabolism_Homo sapiens_hsa004800.72133697
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.70740387
55T cell receptor signaling pathway_Homo sapiens_hsa046600.69576162
56Fatty acid elongation_Homo sapiens_hsa000620.68999060
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66719378
58Apoptosis_Homo sapiens_hsa042100.66547967
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66200931
60Influenza A_Homo sapiens_hsa051640.65473567
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63006521
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62708494
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.62649072
64Hepatitis B_Homo sapiens_hsa051610.61975377
65Leishmaniasis_Homo sapiens_hsa051400.61350212
66Hippo signaling pathway_Homo sapiens_hsa043900.60867820
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60806271
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60127936
69Selenocompound metabolism_Homo sapiens_hsa004500.59935840
70Acute myeloid leukemia_Homo sapiens_hsa052210.58301165
71Biosynthesis of amino acids_Homo sapiens_hsa012300.57480714
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56002974
73Colorectal cancer_Homo sapiens_hsa052100.55765602
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55322542
75Prostate cancer_Homo sapiens_hsa052150.54904533
76Fructose and mannose metabolism_Homo sapiens_hsa000510.54673107
77N-Glycan biosynthesis_Homo sapiens_hsa005100.53627414
78Vitamin B6 metabolism_Homo sapiens_hsa007500.53383783
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.51585944
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51365130
81Osteoclast differentiation_Homo sapiens_hsa043800.47024303
82Other glycan degradation_Homo sapiens_hsa005110.46828336
83Chronic myeloid leukemia_Homo sapiens_hsa052200.45968315
84Adherens junction_Homo sapiens_hsa045200.44930367
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44857811
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44519106
87Thyroid cancer_Homo sapiens_hsa052160.44448310
88Steroid biosynthesis_Homo sapiens_hsa001000.44162396
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41831702
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.40786027
91Hedgehog signaling pathway_Homo sapiens_hsa043400.39187892
92Endometrial cancer_Homo sapiens_hsa052130.39179841
93Small cell lung cancer_Homo sapiens_hsa052220.38860306
94Viral myocarditis_Homo sapiens_hsa054160.38256784
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37906314
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37396984
97Non-small cell lung cancer_Homo sapiens_hsa052230.36953418
98Toxoplasmosis_Homo sapiens_hsa051450.36749852
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36676321
100Huntingtons disease_Homo sapiens_hsa050160.35984853
101Pancreatic cancer_Homo sapiens_hsa052120.35888190
102Alcoholism_Homo sapiens_hsa050340.33106792
103Glioma_Homo sapiens_hsa052140.32907944
104Asthma_Homo sapiens_hsa053100.32413165
105Tuberculosis_Homo sapiens_hsa051520.32348300
106Wnt signaling pathway_Homo sapiens_hsa043100.32281783
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32101050
108HIF-1 signaling pathway_Homo sapiens_hsa040660.30931217
109MicroRNAs in cancer_Homo sapiens_hsa052060.30273987
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.30163779
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29803721
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29324723
113Notch signaling pathway_Homo sapiens_hsa043300.29197502
114Melanoma_Homo sapiens_hsa052180.29139116
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29127576
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27604447
117Salmonella infection_Homo sapiens_hsa051320.27563151
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26572492
119Allograft rejection_Homo sapiens_hsa053300.25940679
120Carbon metabolism_Homo sapiens_hsa012000.25731117
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24309405
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24289852
123Metabolic pathways_Homo sapiens_hsa011000.24066007
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.23479047
125TGF-beta signaling pathway_Homo sapiens_hsa043500.22685271
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22620158
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.21878521
128VEGF signaling pathway_Homo sapiens_hsa043700.21841054
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21647830
130Pathways in cancer_Homo sapiens_hsa052000.21587904
131Proteoglycans in cancer_Homo sapiens_hsa052050.21467711
132Platelet activation_Homo sapiens_hsa046110.20815264
133Renin-angiotensin system_Homo sapiens_hsa046140.20550414
134Parkinsons disease_Homo sapiens_hsa050120.20059915
135Sulfur relay system_Homo sapiens_hsa041220.16805779
136Fatty acid metabolism_Homo sapiens_hsa012120.16761657
137Protein export_Homo sapiens_hsa030600.14801482

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