FANCD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.53219040
2DNA unwinding involved in DNA replication (GO:0006268)5.32261745
3nuclear pore organization (GO:0006999)5.32183036
4nuclear pore complex assembly (GO:0051292)5.26048280
5DNA strand elongation involved in DNA replication (GO:0006271)4.90101213
6DNA replication initiation (GO:0006270)4.86242147
7mitotic chromosome condensation (GO:0007076)4.85367826
8protein localization to chromosome, centromeric region (GO:0071459)4.78820439
9DNA replication-dependent nucleosome organization (GO:0034723)4.78059652
10DNA replication-dependent nucleosome assembly (GO:0006335)4.78059652
11mitotic sister chromatid segregation (GO:0000070)4.72089404
12DNA strand elongation (GO:0022616)4.63799263
13telomere maintenance via semi-conservative replication (GO:0032201)4.60626641
14DNA replication checkpoint (GO:0000076)4.59054679
15sister chromatid segregation (GO:0000819)4.52704504
16mitotic metaphase plate congression (GO:0007080)4.48104216
17attachment of spindle microtubules to kinetochore (GO:0008608)4.44568735
18mitotic nuclear envelope disassembly (GO:0007077)4.40804666
19chromatin remodeling at centromere (GO:0031055)4.37828953
20kinetochore organization (GO:0051383)4.36151731
21mitotic recombination (GO:0006312)4.28618609
22CENP-A containing nucleosome assembly (GO:0034080)4.28078721
23telomere maintenance via recombination (GO:0000722)4.28024736
24replication fork processing (GO:0031297)4.26624354
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.22184817
26regulation of DNA endoreduplication (GO:0032875)4.13299713
27nuclear envelope disassembly (GO:0051081)4.11952586
28membrane disassembly (GO:0030397)4.11952586
29DNA ligation (GO:0006266)4.08525079
30metaphase plate congression (GO:0051310)4.08418191
31pore complex assembly (GO:0046931)4.04781874
32negative regulation of DNA-dependent DNA replication (GO:2000104)4.01506719
33DNA replication-independent nucleosome organization (GO:0034724)4.01428089
34DNA replication-independent nucleosome assembly (GO:0006336)4.01428089
35DNA double-strand break processing (GO:0000729)3.97129634
36mitotic sister chromatid cohesion (GO:0007064)3.94101400
37DNA geometric change (GO:0032392)3.93198352
38meiotic chromosome segregation (GO:0045132)3.93083831
39regulation of histone H3-K9 methylation (GO:0051570)3.92878177
40DNA duplex unwinding (GO:0032508)3.92043606
41histone exchange (GO:0043486)3.88767963
42positive regulation of chromosome segregation (GO:0051984)3.84956959
43regulation of sister chromatid cohesion (GO:0007063)3.83846742
44DNA topological change (GO:0006265)3.80029991
45nucleotide-excision repair, DNA gap filling (GO:0006297)3.77679024
46regulation of spindle organization (GO:0090224)3.75676144
47establishment of chromosome localization (GO:0051303)3.74746465
48protein K6-linked ubiquitination (GO:0085020)3.71903819
49telomere maintenance via telomere lengthening (GO:0010833)3.71669829
50spindle assembly involved in mitosis (GO:0090307)3.71444134
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.71266959
52folic acid-containing compound biosynthetic process (GO:0009396)3.70313434
53IMP biosynthetic process (GO:0006188)3.69684733
54DNA strand renaturation (GO:0000733)3.68861922
55regulation of chromosome segregation (GO:0051983)3.68600793
56nucleobase biosynthetic process (GO:0046112)3.67971400
57kinetochore assembly (GO:0051382)3.62695528
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.58518324
59positive regulation of mitotic sister chromatid separation (GO:1901970)3.58518324
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.58518324
61chromatin assembly or disassembly (GO:0006333)3.58125905
62double-strand break repair via nonhomologous end joining (GO:0006303)3.57536946
63non-recombinational repair (GO:0000726)3.57536946
64regulation of centrosome cycle (GO:0046605)3.55494876
65establishment of integrated proviral latency (GO:0075713)3.55370640
66protein localization to chromosome (GO:0034502)3.53005688
67spindle checkpoint (GO:0031577)3.50110293
68chromosome condensation (GO:0030261)3.48860280
69negative regulation of chromosome segregation (GO:0051985)3.48285580
70chromosome segregation (GO:0007059)3.45956535
71DNA conformation change (GO:0071103)3.45554498
72regulation of mitotic metaphase/anaphase transition (GO:0030071)3.43645156
73regulation of centriole replication (GO:0046599)3.43494962
74somatic hypermutation of immunoglobulin genes (GO:0016446)3.42390567
75somatic diversification of immune receptors via somatic mutation (GO:0002566)3.42390567
76negative regulation of histone methylation (GO:0031061)3.41977136
77regulation of mitotic spindle organization (GO:0060236)3.41369416
78spindle assembly checkpoint (GO:0071173)3.41057163
79negative regulation of mitotic sister chromatid separation (GO:2000816)3.39582460
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.39582460
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.39582460
82negative regulation of sister chromatid segregation (GO:0033046)3.39582460
83regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.36734095
84translesion synthesis (GO:0019985)3.35519422
85regulation of posttranscriptional gene silencing (GO:0060147)3.33207116
86regulation of gene silencing by miRNA (GO:0060964)3.33207116
87regulation of gene silencing by RNA (GO:0060966)3.33207116
88heterochromatin organization (GO:0070828)3.32553047
89recombinational repair (GO:0000725)3.32276300
90regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31531410
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.30758226
92double-strand break repair via homologous recombination (GO:0000724)3.30116902
93DNA catabolic process, exonucleolytic (GO:0000738)3.29862782
94regulation of mitotic sister chromatid separation (GO:0010965)3.29860255
95regulation of mitotic sister chromatid segregation (GO:0033047)3.29860255
96regulation of sister chromatid segregation (GO:0033045)3.29860255
97mitotic spindle assembly checkpoint (GO:0007094)3.29787121
98mitotic spindle checkpoint (GO:0071174)3.29653983
99mitotic G2/M transition checkpoint (GO:0044818)3.27706376
100resolution of meiotic recombination intermediates (GO:0000712)3.27194207
101microtubule depolymerization (GO:0007019)3.25952187
102regulation of mitotic spindle checkpoint (GO:1903504)3.24640754
103regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24640754
104DNA packaging (GO:0006323)3.24284453
105formation of translation preinitiation complex (GO:0001731)3.23035667
106ATP-dependent chromatin remodeling (GO:0043044)3.20924240
107postreplication repair (GO:0006301)3.19952032
108pre-miRNA processing (GO:0031054)3.19025192
109purine nucleobase biosynthetic process (GO:0009113)3.18248731
110IMP metabolic process (GO:0046040)3.18046679
111telomere maintenance (GO:0000723)3.17584707
112inner cell mass cell proliferation (GO:0001833)3.17275849
113chromatin assembly (GO:0031497)3.16988511
114telomere organization (GO:0032200)3.16133079
115somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.15112435
116somatic cell DNA recombination (GO:0016444)3.15112435
117nuclear envelope organization (GO:0006998)3.14580000
118centriole replication (GO:0007099)3.14019022
119somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.13519625
120somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.13519625
121isotype switching (GO:0045190)3.13519625
122regulation of nuclear cell cycle DNA replication (GO:0033262)3.12803863
123somatic recombination of immunoglobulin gene segments (GO:0016447)3.11158064
124microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.10557931
125regulation of double-strand break repair via homologous recombination (GO:0010569)3.09049771
126regulation of helicase activity (GO:0051095)3.08109176
127maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.06150082
128mismatch repair (GO:0006298)3.05250168
129dosage compensation (GO:0007549)3.04410953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.97824285
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.69220857
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.81178077
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.79181768
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97916995
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.81530684
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79454501
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60781466
9AR_21909140_ChIP-Seq_LNCAP_Human2.51570923
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.46520079
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.40641517
12* E2F1_21310950_ChIP-Seq_MCF-7_Human2.39139364
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32097671
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31462638
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.24060844
16* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.20268822
17* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18619517
18* XRN2_22483619_ChIP-Seq_HELA_Human2.03745852
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00262318
20* E2F7_22180533_ChIP-Seq_HELA_Human11.0632946
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.99774203
22* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95491497
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93619610
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91146351
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90228959
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.85502502
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84828218
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80684426
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78665227
30* VDR_23849224_ChIP-Seq_CD4+_Human1.76064123
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75286804
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.69751186
33FOXP3_21729870_ChIP-Seq_TREG_Human1.64895896
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63992798
35MYC_22102868_ChIP-Seq_BL_Human1.58461795
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.56729447
37* TTF2_22483619_ChIP-Seq_HELA_Human1.56457161
38DCP1A_22483619_ChIP-Seq_HELA_Human1.54587102
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53246276
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53242596
41EWS_26573619_Chip-Seq_HEK293_Human1.52116805
42ELK1_19687146_ChIP-ChIP_HELA_Human1.45907613
43CIITA_25753668_ChIP-Seq_RAJI_Human1.44134532
44* GABP_19822575_ChIP-Seq_HepG2_Human1.43314882
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42904480
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42265901
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42028422
48KDM5A_27292631_Chip-Seq_BREAST_Human1.41391523
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.40923750
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37376983
51FUS_26573619_Chip-Seq_HEK293_Human1.37223877
52IRF1_19129219_ChIP-ChIP_H3396_Human1.36596767
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35987080
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35508520
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33716515
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.31155188
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31141503
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29934664
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28538582
60ZNF274_21170338_ChIP-Seq_K562_Hela1.27172508
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26700539
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.26176655
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.25437559
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25342853
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25342853
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25342853
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23310449
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20704937
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20406319
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19361304
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18352117
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16823809
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15334960
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14650907
75* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14596930
76TFEB_21752829_ChIP-Seq_HELA_Human1.11791974
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.10523502
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10022320
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.04679027
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04307388
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04123443
82* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03719301
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01153888
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01109289
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01023638
86VDR_22108803_ChIP-Seq_LS180_Human0.99993786
87NANOG_21062744_ChIP-ChIP_HESCs_Human0.99066711
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98693464
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97424317
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96150185
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94548430
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92739746
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91095427
94* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91036169
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89943873
96VDR_21846776_ChIP-Seq_THP-1_Human0.89145121
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88518437
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87976607
99MYC_18940864_ChIP-ChIP_HL60_Human0.86935418
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86311332
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84165123
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83639281
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83405261
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83084524
105TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82996155
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80832821
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80059013
108PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78958737
109IGF1R_20145208_ChIP-Seq_DFB_Human0.78574542
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.77320928
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77292348
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75494179
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73935279
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.72382768
115SOX2_18692474_ChIP-Seq_MESCs_Mouse0.71874304
116* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70515215
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69686759
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.68941002
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.65418620
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65308168
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.63038758
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.62390227
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.61266029
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.59066563
125HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.58225294
126SOX9_26525672_Chip-Seq_HEART_Mouse0.55776665
127FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.54823120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability5.18140939
2MP0003111_abnormal_nucleus_morphology4.89882999
3MP0003693_abnormal_embryo_hatching4.85913542
4MP0008057_abnormal_DNA_replication4.65372988
5MP0004957_abnormal_blastocyst_morpholog4.26288153
6MP0003077_abnormal_cell_cycle4.23833349
7MP0008058_abnormal_DNA_repair3.31334232
8MP0008877_abnormal_DNA_methylation3.21871754
9MP0010307_abnormal_tumor_latency2.62905890
10MP0008932_abnormal_embryonic_tissue2.61216514
11MP0001730_embryonic_growth_arrest2.54549317
12MP0008007_abnormal_cellular_replicative2.54433715
13MP0010352_gastrointestinal_tract_polyps2.50853552
14MP0000350_abnormal_cell_proliferation2.40304073
15MP0003123_paternal_imprinting2.21778132
16MP0005076_abnormal_cell_differentiation2.00502517
17MP0003786_premature_aging1.97342162
18MP0001672_abnormal_embryogenesis/_devel1.94942032
19MP0005380_embryogenesis_phenotype1.94942032
20MP0009697_abnormal_copulation1.91844325
21MP0001697_abnormal_embryo_size1.87042612
22MP0002396_abnormal_hematopoietic_system1.84724914
23MP0002085_abnormal_embryonic_tissue1.78493503
24MP0002938_white_spotting1.78087411
25MP0002084_abnormal_developmental_patter1.72734575
26MP0003984_embryonic_growth_retardation1.71350697
27MP0003890_abnormal_embryonic-extraembry1.69285299
28* MP0002210_abnormal_sex_determination1.69169923
29MP0003121_genomic_imprinting1.68258242
30MP0002088_abnormal_embryonic_growth/wei1.67198535
31MP0002080_prenatal_lethality1.67013569
32MP0000372_irregular_coat_pigmentation1.66934067
33* MP0004197_abnormal_fetal_growth/weight/1.59731517
34MP0002086_abnormal_extraembryonic_tissu1.59527721
35MP0004808_abnormal_hematopoietic_stem1.49919387
36* MP0001929_abnormal_gametogenesis1.48736597
37MP0000490_abnormal_crypts_of1.48049628
38* MP0001145_abnormal_male_reproductive1.47099028
39* MP0000313_abnormal_cell_death1.44070008
40MP0002102_abnormal_ear_morphology1.42119457
41MP0003567_abnormal_fetal_cardiomyocyte1.40520387
42* MP0002019_abnormal_tumor_incidence1.37996853
43MP0001293_anophthalmia1.37282525
44MP0006072_abnormal_retinal_apoptosis1.26700214
45* MP0000653_abnormal_sex_gland1.24674377
46MP0001485_abnormal_pinna_reflex1.15705782
47MP0003705_abnormal_hypodermis_morpholog1.14845005
48MP0000049_abnormal_middle_ear1.13706612
49MP0006035_abnormal_mitochondrial_morpho1.13474496
50MP0003718_maternal_effect1.11336238
51MP0000537_abnormal_urethra_morphology1.08582921
52MP0002751_abnormal_autonomic_nervous1.07680956
53MP0005075_abnormal_melanosome_morpholog1.05455646
54MP0005397_hematopoietic_system_phenotyp1.04648520
55MP0001545_abnormal_hematopoietic_system1.04648520
56MP0002653_abnormal_ependyma_morphology1.02998091
57MP0009278_abnormal_bone_marrow1.01532199
58MP0003698_abnormal_male_reproductive1.00838773
59MP0000703_abnormal_thymus_morphology1.00520771
60MP0004147_increased_porphyrin_level0.99490611
61MP0003119_abnormal_digestive_system0.99472079
62MP0000631_abnormal_neuroendocrine_gland0.98164916
63MP0010030_abnormal_orbit_morphology0.97593367
64MP0003937_abnormal_limbs/digits/tail_de0.97094351
65MP0003315_abnormal_perineum_morphology0.96661837
66MP0005171_absent_coat_pigmentation0.96171069
67MP0001661_extended_life_span0.95031651
68MP0000516_abnormal_urinary_system0.94416801
69MP0005367_renal/urinary_system_phenotyp0.94416801
70MP0008789_abnormal_olfactory_epithelium0.93437833
71MP0003566_abnormal_cell_adhesion0.93197422
72MP0004133_heterotaxia0.90079919
73MP0009672_abnormal_birth_weight0.89742417
74MP0002160_abnormal_reproductive_system0.85290484
75MP0001529_abnormal_vocalization0.84284226
76MP0005621_abnormal_cell_physiology0.83992209
77MP0005384_cellular_phenotype0.83972975
78MP0009703_decreased_birth_body0.83438674
79MP0002009_preneoplasia0.83208930
80MP0002095_abnormal_skin_pigmentation0.82665843
81MP0000569_abnormal_digit_pigmentation0.81898212
82MP0001915_intracranial_hemorrhage0.81376569
83MP0002398_abnormal_bone_marrow0.81361707
84MP0002111_abnormal_tail_morphology0.79682181
85MP0002092_abnormal_eye_morphology0.79108066
86* MP0001119_abnormal_female_reproductive0.77980661
87MP0009053_abnormal_anal_canal0.77916442
88MP0005174_abnormal_tail_pigmentation0.77911926
89MP0002722_abnormal_immune_system0.77700856
90MP0002163_abnormal_gland_morphology0.76989727
91MP0002233_abnormal_nose_morphology0.76839623
92MP0005253_abnormal_eye_physiology0.75061113
93MP0003806_abnormal_nucleotide_metabolis0.74764833
94MP0002161_abnormal_fertility/fecundity0.73785992
95MP0010234_abnormal_vibrissa_follicle0.72975074
96MP0005646_abnormal_pituitary_gland0.71800563
97MP0006036_abnormal_mitochondrial_physio0.71684722
98MP0005394_taste/olfaction_phenotype0.71471703
99MP0005499_abnormal_olfactory_system0.71471703
100MP0000689_abnormal_spleen_morphology0.71271346
101MP0003941_abnormal_skin_development0.69830532
102MP0005391_vision/eye_phenotype0.69344532
103MP0005023_abnormal_wound_healing0.69003183
104MP0001286_abnormal_eye_development0.68552660
105MP0003936_abnormal_reproductive_system0.68092109
106MP0003861_abnormal_nervous_system0.68084155
107MP0002234_abnormal_pharynx_morphology0.67654161
108MP0003938_abnormal_ear_development0.67438263
109MP0000358_abnormal_cell_content/0.67421157
110MP0004264_abnormal_extraembryonic_tissu0.67108142
111MP0005389_reproductive_system_phenotype0.67091303
112MP0003136_yellow_coat_color0.66516658
113MP0001849_ear_inflammation0.66399212
114MP0002075_abnormal_coat/hair_pigmentati0.66353925
115MP0006292_abnormal_olfactory_placode0.66053955
116MP0000428_abnormal_craniofacial_morphol0.65992569
117MP0000858_altered_metastatic_potential0.65745812
118MP0000432_abnormal_head_morphology0.65629908
119MP0009333_abnormal_splenocyte_physiolog0.65241398
120MP0001919_abnormal_reproductive_system0.64744181
121MP0000647_abnormal_sebaceous_gland0.64495091
122MP0002282_abnormal_trachea_morphology0.64241910
123MP0008995_early_reproductive_senescence0.64082001
124MP0003755_abnormal_palate_morphology0.63739431
125MP0000371_diluted_coat_color0.63421454
126MP0003115_abnormal_respiratory_system0.62940053
127MP0001324_abnormal_eye_pigmentation0.62498518
128MP0002925_abnormal_cardiovascular_devel0.61873802
129MP0006054_spinal_hemorrhage0.61771299
130MP0003787_abnormal_imprinting0.61061901
131* MP0002697_abnormal_eye_size0.60948192
132MP0003448_altered_tumor_morphology0.59579515
133MP0004233_abnormal_muscle_weight0.59251486
134MP0000733_abnormal_muscle_development0.57332918
135MP0005501_abnormal_skin_physiology0.56557304
136MP0002429_abnormal_blood_cell0.56480477
137MP0003699_abnormal_female_reproductive0.56439324

Predicted human phenotypes

RankGene SetZ-score
1* Chromsome breakage (HP:0040012)4.59533885
2* Chromosomal breakage induced by crosslinking agents (HP:0003221)4.32050698
3Birth length less than 3rd percentile (HP:0003561)4.27603527
4Ependymoma (HP:0002888)4.17510277
5Medulloblastoma (HP:0002885)3.85211958
6* Abnormality of chromosome stability (HP:0003220)3.66961321
7Selective tooth agenesis (HP:0001592)3.59510936
8Impulsivity (HP:0100710)3.58549307
9Colon cancer (HP:0003003)3.56124829
10Breast hypoplasia (HP:0003187)3.48236380
11Agnosia (HP:0010524)3.21655840
12Rhabdomyosarcoma (HP:0002859)3.18061706
13* Meckel diverticulum (HP:0002245)3.18056794
14Patellar aplasia (HP:0006443)3.15469445
15Increased nuchal translucency (HP:0010880)3.10999902
16Abnormality of the labia minora (HP:0012880)3.10815085
17* Aplasia/Hypoplasia of the uvula (HP:0010293)3.02803150
18* Abnormality of the ileum (HP:0001549)3.02400593
1911 pairs of ribs (HP:0000878)2.98405677
20Astrocytoma (HP:0009592)2.96471877
21Abnormality of the astrocytes (HP:0100707)2.96471877
22* Abnormality of the preputium (HP:0100587)2.92742137
23Volvulus (HP:0002580)2.91312826
24* Duodenal stenosis (HP:0100867)2.88934970
25* Small intestinal stenosis (HP:0012848)2.88934970
26Aplasia/Hypoplasia of the patella (HP:0006498)2.88516278
27Abnormal number of incisors (HP:0011064)2.81437978
28Stenosis of the external auditory canal (HP:0000402)2.76009454
29Proximal placement of thumb (HP:0009623)2.71727211
30* Sloping forehead (HP:0000340)2.68231732
31Carpal bone hypoplasia (HP:0001498)2.67371415
32* Absent radius (HP:0003974)2.67256891
33Glioma (HP:0009733)2.66751613
34* Myelodysplasia (HP:0002863)2.66568973
35Basal cell carcinoma (HP:0002671)2.65843838
36Abnormal lung lobation (HP:0002101)2.63581935
37Deviation of the thumb (HP:0009603)2.61418562
38Missing ribs (HP:0000921)2.60570069
39* Reticulocytopenia (HP:0001896)2.59632907
40* Ectopic kidney (HP:0000086)2.58634145
41Neoplasm of striated muscle (HP:0009728)2.56488472
42Supernumerary spleens (HP:0009799)2.52103742
43Neoplasm of the oral cavity (HP:0100649)2.51128894
44Nephroblastoma (Wilms tumor) (HP:0002667)2.49960965
45Oral leukoplakia (HP:0002745)2.47493097
46* Absent forearm bone (HP:0003953)2.46411903
47* Aplasia involving forearm bones (HP:0009822)2.46411903
48Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.45787433
49Short 1st metacarpal (HP:0010034)2.45787433
50* Cafe-au-lait spot (HP:0000957)2.45105828
51Short 4th metacarpal (HP:0010044)2.44063677
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44063677
53Prominent nose (HP:0000448)2.42518034
54Abnormality of the anterior horn cell (HP:0006802)2.41601467
55Degeneration of anterior horn cells (HP:0002398)2.41601467
56Neoplasm of the pancreas (HP:0002894)2.41122233
57Abnormality of cochlea (HP:0000375)2.38352376
58* Horseshoe kidney (HP:0000085)2.38315881
59* Abnormality of the carotid arteries (HP:0005344)2.37409643
60* Abnormality of the duodenum (HP:0002246)2.37220189
61High pitched voice (HP:0001620)2.36646989
62Pendular nystagmus (HP:0012043)2.35820529
63Embryonal renal neoplasm (HP:0011794)2.32073639
64Facial hemangioma (HP:0000329)2.29303159
65Rectovaginal fistula (HP:0000143)2.28813293
66Rectal fistula (HP:0100590)2.28813293
67Abnormality of cells of the erythroid lineage (HP:0012130)2.27686343
68Biliary tract neoplasm (HP:0100574)2.27487382
69* Tracheoesophageal fistula (HP:0002575)2.25867941
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.22415651
71Squamous cell carcinoma (HP:0002860)2.21826172
72* Absent thumb (HP:0009777)2.21158691
73* Bone marrow hypocellularity (HP:0005528)2.20863489
74Abnormality of abdominal situs (HP:0011620)2.20430136
75Abdominal situs inversus (HP:0003363)2.20430136
76Atresia of the external auditory canal (HP:0000413)2.16725190
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12371016
78Abnormality of the 1st metacarpal (HP:0010009)2.11547555
79Abnormal number of erythroid precursors (HP:0012131)2.10907914
80Abnormal spermatogenesis (HP:0008669)2.09436095
81Hypoplasia of the pons (HP:0012110)2.09407522
82Premature graying of hair (HP:0002216)2.08443282
83Sandal gap (HP:0001852)2.06457276
84Amaurosis fugax (HP:0100576)2.04521294
85Aplasia/hypoplasia of the humerus (HP:0006507)2.04288922
86Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03904466
87* Short thumb (HP:0009778)2.02445337
88Neoplasm of the colon (HP:0100273)2.01674780
89Abnormality of the pons (HP:0007361)2.00460392
90Ovarian neoplasm (HP:0100615)2.00395477
91Neoplasm of the adrenal cortex (HP:0100641)1.98811462
92Rough bone trabeculation (HP:0100670)1.96299120
93Intestinal fistula (HP:0100819)1.95493113
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94589760
95Abnormality of homocysteine metabolism (HP:0010919)1.91947091
96Homocystinuria (HP:0002156)1.91947091
97Small hand (HP:0200055)1.91621433
98* Choanal atresia (HP:0000453)1.90873659
99Cellular immunodeficiency (HP:0005374)1.89596598
100Cutaneous melanoma (HP:0012056)1.89471918
101Abnormality of the parathyroid morphology (HP:0011766)1.88516873
102Acute necrotizing encephalopathy (HP:0006965)1.88166363
103Gastrointestinal carcinoma (HP:0002672)1.88048502
104Malignant gastrointestinal tract tumors (HP:0006749)1.88048502
105Cortical dysplasia (HP:0002539)1.87803196
106Abnormality of chromosome segregation (HP:0002916)1.87310061
107Morphological abnormality of the inner ear (HP:0011390)1.86931504
108Acute encephalopathy (HP:0006846)1.86747719
109Rib fusion (HP:0000902)1.85978839
110Embryonal neoplasm (HP:0002898)1.85194882
111Pancreatic cysts (HP:0001737)1.84841827
112Optic nerve coloboma (HP:0000588)1.84546701
113Skull defect (HP:0001362)1.83140856
114Metaphyseal cupping (HP:0003021)1.82950004
115Short humerus (HP:0005792)1.80430718
116* Arteriovenous malformation (HP:0100026)1.80404876
117* Triphalangeal thumb (HP:0001199)1.79990679
118Freckling (HP:0001480)1.77416528
119Preaxial hand polydactyly (HP:0001177)1.76850771
120* Clubbing of toes (HP:0100760)1.76819088
121Supernumerary bones of the axial skeleton (HP:0009144)1.75777637
122Hypopigmentation of the fundus (HP:0007894)1.75631793
123Vaginal fistula (HP:0004320)1.75332724
124Aplastic anemia (HP:0001915)1.74482283
125Combined immunodeficiency (HP:0005387)1.73262410
126Overlapping toe (HP:0001845)1.72757188
127Abnormality of the proximal phalanges of the hand (HP:0009834)1.70934698
128Abnormal mitochondria in muscle tissue (HP:0008316)1.69626629
129Supernumerary ribs (HP:0005815)1.69362651
130Abnormality of the calcaneus (HP:0008364)1.68506708
131Aplasia/Hypoplasia of the earlobes (HP:0009906)1.68378124
132Spinal muscular atrophy (HP:0007269)1.68234106
133Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68210547
134Pancreatic fibrosis (HP:0100732)1.67792141
135Hyperglycinemia (HP:0002154)1.65464077
136Intestinal atresia (HP:0011100)1.64955542
137Methylmalonic acidemia (HP:0002912)1.64327618
138Abnormality of methionine metabolism (HP:0010901)1.64303819
139Bilateral microphthalmos (HP:0007633)1.62882702
140Short phalanx of the thumb (HP:0009660)1.62600225
141Increased CSF lactate (HP:0002490)1.62133200
142Dandy-Walker malformation (HP:0001305)1.61282162
143High anterior hairline (HP:0009890)1.59248380
144Holoprosencephaly (HP:0001360)1.57524606
145Septo-optic dysplasia (HP:0100842)1.57015967
146True hermaphroditism (HP:0010459)1.51815661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.52028116
2WEE14.61916396
3BUB13.86783202
4NEK23.54737275
5CDK123.12488860
6NEK12.95201415
7TTK2.91912642
8VRK22.68290222
9BRSK22.44165809
10SRPK12.43322238
11PLK12.25701312
12ACVR1B2.13883099
13TAF12.12134783
14EIF2AK12.00343476
15TLK11.89701660
16NUAK11.88056589
17* ATR1.85754714
18AURKB1.83848047
19EEF2K1.78872390
20CHEK21.76826627
21CDK71.75162430
22PASK1.69398220
23TSSK61.67984494
24RPS6KB21.63970394
25PLK31.61653277
26CCNB11.60007455
27CDK41.58365415
28BRSK11.57265092
29PLK41.54818460
30MAP3K81.50721276
31* CHEK11.50471143
32STK101.49872371
33VRK11.47314279
34BMPR1B1.45817212
35STK41.44142800
36WNK31.41310894
37MKNK11.36697659
38TRIM281.35724481
39BRD41.34254388
40SCYL21.27850293
41TESK21.25938583
42TNIK1.20498603
43AURKA1.20017294
44MAP3K101.18768948
45PNCK1.18538722
46* ATM1.16790830
47DYRK31.16263302
48CDK61.14765209
49EPHA21.08948994
50ZAK1.08658228
51STK161.07610879
52MST41.07483567
53MKNK21.04567524
54RPS6KA41.04131157
55CDK21.02731423
56FRK1.01843718
57PLK20.95539703
58PDK40.95428263
59PDK30.95428263
60PAK40.95306456
61EIF2AK30.95292028
62GRK10.95144657
63MELK0.94394439
64PKN20.93618968
65ALK0.85894395
66STK30.84628131
67NME10.84355961
68PIM10.83495383
69CDK10.83420752
70CLK10.81848377
71FLT30.81105044
72TGFBR10.80602669
73TESK10.77286100
74SMG10.68272007
75MTOR0.64489669
76CSNK2A20.59200403
77CSNK1G10.56681073
78NME20.54487243
79DYRK20.54162274
80CSNK1D0.50670549
81LRRK20.50391089
82MAP4K20.50084392
83RPS6KA50.49705932
84CSNK2A10.49618771
85CSNK1G30.47726792
86CDK30.47678515
87AKT20.47443038
88PAK10.46963200
89* PRKDC0.46885410
90ICK0.45822350
91OXSR10.44563681
92PRKCI0.43299825
93CSNK1A1L0.42476122
94STK38L0.40284375
95GRK60.39742070
96MAP3K40.39178851
97MAPKAPK50.38232958
98CDK90.36958297
99CSNK1E0.36932976
100LATS10.36142607
101PDK20.35895362
102EIF2AK20.35623656
103CSNK1G20.34960079
104NLK0.34684071
105* MAPK140.34564266
106CAMK1G0.33753131
107FGFR10.33309248
108STK390.32836532
109BCR0.31856126
110INSRR0.31766639
111TTN0.31103619
112MAPK130.30275435
113AKT10.29745220
114ADRBK20.29570092
115MET0.29017932
116FGFR20.28117237
117WNK40.26978948
118GSK3B0.26848250
119MAP4K10.26397438
120CDK80.25996489
121BRAF0.25230162
122MARK30.23650864
123MAPK10.21841682
124MAP2K30.21790080
125PBK0.21000983
126CSF1R0.20778497
127CDK150.19719914
128MAPKAPK30.19334636
129CDK11A0.18922993
130RPS6KB10.18623500
131YES10.18410916
132PAK20.17344486
133CDK180.17163888

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.46217210
2Mismatch repair_Homo sapiens_hsa034304.75520596
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55226613
4Homologous recombination_Homo sapiens_hsa034403.38287299
5Cell cycle_Homo sapiens_hsa041103.26238970
6RNA transport_Homo sapiens_hsa030133.24929627
7Spliceosome_Homo sapiens_hsa030403.24402832
8Base excision repair_Homo sapiens_hsa034103.17713513
9Nucleotide excision repair_Homo sapiens_hsa034203.03064301
10One carbon pool by folate_Homo sapiens_hsa006702.97600211
11* Fanconi anemia pathway_Homo sapiens_hsa034602.79256508
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59243965
13Non-homologous end-joining_Homo sapiens_hsa034502.48648573
14RNA polymerase_Homo sapiens_hsa030202.34594058
15mRNA surveillance pathway_Homo sapiens_hsa030152.13695649
16Ribosome_Homo sapiens_hsa030102.10557378
17Pyrimidine metabolism_Homo sapiens_hsa002402.03893909
18Proteasome_Homo sapiens_hsa030502.00172806
19Systemic lupus erythematosus_Homo sapiens_hsa053221.92822465
20Basal transcription factors_Homo sapiens_hsa030221.92062222
21RNA degradation_Homo sapiens_hsa030181.86451652
22p53 signaling pathway_Homo sapiens_hsa041151.78890867
23Oocyte meiosis_Homo sapiens_hsa041141.43332255
24Protein export_Homo sapiens_hsa030601.40969733
25Viral carcinogenesis_Homo sapiens_hsa052031.32731690
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29907715
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27789956
28Epstein-Barr virus infection_Homo sapiens_hsa051691.18290638
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17932129
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16600149
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07148018
32Purine metabolism_Homo sapiens_hsa002301.04495669
33Propanoate metabolism_Homo sapiens_hsa006401.02618473
34Parkinsons disease_Homo sapiens_hsa050121.02239158
35Selenocompound metabolism_Homo sapiens_hsa004501.00770060
36Herpes simplex infection_Homo sapiens_hsa051681.00265867
37MicroRNAs in cancer_Homo sapiens_hsa052060.98576230
38Oxidative phosphorylation_Homo sapiens_hsa001900.98307143
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97867101
40Steroid biosynthesis_Homo sapiens_hsa001000.96735614
41Pyruvate metabolism_Homo sapiens_hsa006200.95499762
42HTLV-I infection_Homo sapiens_hsa051660.91674641
43Antigen processing and presentation_Homo sapiens_hsa046120.90102432
44Alcoholism_Homo sapiens_hsa050340.88675261
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86268551
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86204907
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84545668
48Biosynthesis of amino acids_Homo sapiens_hsa012300.82107450
49Small cell lung cancer_Homo sapiens_hsa052220.75466678
50Pentose phosphate pathway_Homo sapiens_hsa000300.69515056
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68589771
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67744650
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66956724
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.63678463
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59900445
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59628671
57Thyroid cancer_Homo sapiens_hsa052160.54899236
58TGF-beta signaling pathway_Homo sapiens_hsa043500.54752606
59Colorectal cancer_Homo sapiens_hsa052100.54436575
60Hippo signaling pathway_Homo sapiens_hsa043900.54436553
61Basal cell carcinoma_Homo sapiens_hsa052170.53196740
62Fatty acid elongation_Homo sapiens_hsa000620.51753628
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48999856
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.48038642
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47484226
66Alzheimers disease_Homo sapiens_hsa050100.47008751
67Apoptosis_Homo sapiens_hsa042100.46723882
68Butanoate metabolism_Homo sapiens_hsa006500.46329295
69Adherens junction_Homo sapiens_hsa045200.46144750
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45926007
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45752313
72Phototransduction_Homo sapiens_hsa047440.45551987
73Metabolic pathways_Homo sapiens_hsa011000.45225733
74Lysine degradation_Homo sapiens_hsa003100.45211862
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.43647761
76mTOR signaling pathway_Homo sapiens_hsa041500.43163936
77Chronic myeloid leukemia_Homo sapiens_hsa052200.42424891
78Nitrogen metabolism_Homo sapiens_hsa009100.42235350
79Legionellosis_Homo sapiens_hsa051340.41062553
80Hepatitis B_Homo sapiens_hsa051610.39790860
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.38758068
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.37970753
83Notch signaling pathway_Homo sapiens_hsa043300.37602960
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36723699
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35396659
86Carbon metabolism_Homo sapiens_hsa012000.34250405
87Bladder cancer_Homo sapiens_hsa052190.33947934
88Vitamin digestion and absorption_Homo sapiens_hsa049770.33208341
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33086995
90HIF-1 signaling pathway_Homo sapiens_hsa040660.32817522
91Pathways in cancer_Homo sapiens_hsa052000.31912477
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.31859713
93Primary immunodeficiency_Homo sapiens_hsa053400.31657086
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31607178
95Prostate cancer_Homo sapiens_hsa052150.31252888
96Vitamin B6 metabolism_Homo sapiens_hsa007500.30921917
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30648471
98Influenza A_Homo sapiens_hsa051640.28542999
99Viral myocarditis_Homo sapiens_hsa054160.28277466
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27782113
101Measles_Homo sapiens_hsa051620.26997489
102Fructose and mannose metabolism_Homo sapiens_hsa000510.26955586
103Hedgehog signaling pathway_Homo sapiens_hsa043400.26944913
104Non-small cell lung cancer_Homo sapiens_hsa052230.26380757
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24030400
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23408546
107Shigellosis_Homo sapiens_hsa051310.23132049
108Tryptophan metabolism_Homo sapiens_hsa003800.22418595
109Pancreatic cancer_Homo sapiens_hsa052120.22336826
110Olfactory transduction_Homo sapiens_hsa047400.21874516
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21804337
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20363976
113Tight junction_Homo sapiens_hsa045300.18901457
114Wnt signaling pathway_Homo sapiens_hsa043100.18294408
115Glutathione metabolism_Homo sapiens_hsa004800.17656501
116N-Glycan biosynthesis_Homo sapiens_hsa005100.17303259
117FoxO signaling pathway_Homo sapiens_hsa040680.17118465
118Ether lipid metabolism_Homo sapiens_hsa005650.15842000
119Fatty acid metabolism_Homo sapiens_hsa012120.15737856
120Proteoglycans in cancer_Homo sapiens_hsa052050.15723776
121Sulfur relay system_Homo sapiens_hsa041220.14584206
122Melanoma_Homo sapiens_hsa052180.14236911
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.13708386
124Acute myeloid leukemia_Homo sapiens_hsa052210.13437609
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13278007
126Peroxisome_Homo sapiens_hsa041460.13127712
127Renin-angiotensin system_Homo sapiens_hsa046140.12749142
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.10672632
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.10625529
130Endometrial cancer_Homo sapiens_hsa052130.09674853
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09351416
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08932653
133B cell receptor signaling pathway_Homo sapiens_hsa046620.08695195
134Sulfur metabolism_Homo sapiens_hsa009200.08566343
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.06561963
136Huntingtons disease_Homo sapiens_hsa050160.06199259
137Galactose metabolism_Homo sapiens_hsa000520.05408075
138Folate biosynthesis_Homo sapiens_hsa007900.04736425

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