FANCA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.73666643
2chromosome condensation (GO:0030261)4.73140330
3kinetochore organization (GO:0051383)4.57858371
4regulation of sister chromatid cohesion (GO:0007063)4.34550049
5negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.17530536
6kinetochore assembly (GO:0051382)4.16834081
7DNA replication initiation (GO:0006270)4.15216878
8DNA strand elongation involved in DNA replication (GO:0006271)4.14322894
9telomere maintenance via semi-conservative replication (GO:0032201)4.11713536
10nuclear pore organization (GO:0006999)4.09986878
11DNA packaging (GO:0006323)4.09838856
12protein localization to chromosome, centromeric region (GO:0071459)4.09378776
13DNA unwinding involved in DNA replication (GO:0006268)4.05301942
14nuclear pore complex assembly (GO:0051292)4.04403166
15regulation of translational fidelity (GO:0006450)4.03384785
16DNA strand elongation (GO:0022616)3.99879319
17heterochromatin organization (GO:0070828)3.98891049
18folic acid-containing compound biosynthetic process (GO:0009396)3.97912070
19CENP-A containing nucleosome assembly (GO:0034080)3.91239350
20mitotic sister chromatid segregation (GO:0000070)3.91140645
21chromatin remodeling at centromere (GO:0031055)3.89665224
22telomere maintenance via recombination (GO:0000722)3.89253425
23meiotic chromosome segregation (GO:0045132)3.88368627
24mitotic recombination (GO:0006312)3.86407399
25DNA strand renaturation (GO:0000733)3.82984740
26sister chromatid segregation (GO:0000819)3.69921763
27regulation of DNA endoreduplication (GO:0032875)3.69481198
28DNA replication checkpoint (GO:0000076)3.68491025
29mitotic metaphase plate congression (GO:0007080)3.68385453
30negative regulation of mRNA processing (GO:0050686)3.65386937
31pore complex assembly (GO:0046931)3.55413376
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.52358042
33microtubule depolymerization (GO:0007019)3.50614748
34mitotic chromosome condensation (GO:0007076)3.50424922
35protein K6-linked ubiquitination (GO:0085020)3.50141677
36L-serine metabolic process (GO:0006563)3.48930865
37DNA replication-independent nucleosome assembly (GO:0006336)3.47669179
38DNA replication-independent nucleosome organization (GO:0034724)3.47669179
39regulation of mammary gland epithelial cell proliferation (GO:0033599)3.46859418
40viral mRNA export from host cell nucleus (GO:0046784)3.46178308
41telomere maintenance via telomere lengthening (GO:0010833)3.44523496
42DNA synthesis involved in DNA repair (GO:0000731)3.43332299
43mitotic nuclear envelope disassembly (GO:0007077)3.40379422
44maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.39155322
45metaphase plate congression (GO:0051310)3.37066054
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.34966007
47DNA geometric change (GO:0032392)3.33710005
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33564286
49folic acid metabolic process (GO:0046655)3.33249232
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32778944
51DNA duplex unwinding (GO:0032508)3.31298486
52negative regulation of mRNA metabolic process (GO:1903312)3.30632780
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.29122832
54negative regulation of RNA splicing (GO:0033119)3.25468224
55mitotic sister chromatid cohesion (GO:0007064)3.25080612
56regulation of histone H3-K9 methylation (GO:0051570)3.24549237
57establishment of chromosome localization (GO:0051303)3.23965326
58mismatch repair (GO:0006298)3.18701867
59peptidyl-lysine dimethylation (GO:0018027)3.17681558
60attachment of spindle microtubules to kinetochore (GO:0008608)3.17321226
61histone exchange (GO:0043486)3.15153241
62DNA replication-dependent nucleosome organization (GO:0034723)3.14962659
63DNA replication-dependent nucleosome assembly (GO:0006335)3.14962659
64positive regulation of chromosome segregation (GO:0051984)3.13071347
65telomere maintenance (GO:0000723)3.11307945
66translesion synthesis (GO:0019985)3.11299139
67IMP biosynthetic process (GO:0006188)3.10341436
68nuclear envelope organization (GO:0006998)3.09147100
69telomere organization (GO:0032200)3.08859287
70chromosome organization (GO:0051276)3.06513144
71membrane disassembly (GO:0030397)3.05690095
72nuclear envelope disassembly (GO:0051081)3.05690095
73sister chromatid cohesion (GO:0007062)3.04095914
74DNA biosynthetic process (GO:0071897)3.03728654
75regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02724881
76intra-S DNA damage checkpoint (GO:0031573)3.01644166
77chromatin assembly or disassembly (GO:0006333)2.99568918
78protein localization to chromosome (GO:0034502)2.97605329
79nucleobase biosynthetic process (GO:0046112)2.97527656
80V(D)J recombination (GO:0033151)2.96875090
81regulation of double-strand break repair via homologous recombination (GO:0010569)2.96779617
82spindle checkpoint (GO:0031577)2.96687970
83nucleosome disassembly (GO:0006337)2.96212510
84protein-DNA complex disassembly (GO:0032986)2.96212510
85regulation of mitotic spindle organization (GO:0060236)2.95927349
86regulation of centrosome duplication (GO:0010824)2.94555127
87double-strand break repair via nonhomologous end joining (GO:0006303)2.94345448
88non-recombinational repair (GO:0000726)2.94345448
89positive regulation of mitotic sister chromatid separation (GO:1901970)2.93698749
90positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93698749
91positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93698749
92regulation of DNA methylation (GO:0044030)2.92349421
93centrosome duplication (GO:0051298)2.92243304
94DNA conformation change (GO:0071103)2.92017974
95positive regulation of cell cycle checkpoint (GO:1901978)2.91935468
96proline biosynthetic process (GO:0006561)2.91390792
97chromosome segregation (GO:0007059)2.90947240
98replication fork processing (GO:0031297)2.89945884
99regulation of chromosome segregation (GO:0051983)2.84793085
100DNA topological change (GO:0006265)2.84330293
101spindle assembly checkpoint (GO:0071173)2.83211476
102negative regulation of chromosome segregation (GO:0051985)2.81566795
103regulation of mitotic metaphase/anaphase transition (GO:0030071)2.81336563
104regulation of telomere maintenance via telomerase (GO:0032210)2.78762156
105regulation of centrosome cycle (GO:0046605)2.78237256
106DNA ligation (GO:0006266)2.76514151
107regulation of helicase activity (GO:0051095)2.74394518
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.73980713
109negative regulation of sister chromatid segregation (GO:0033046)2.73980713
110negative regulation of mitotic sister chromatid separation (GO:2000816)2.73980713
111negative regulation of mitotic sister chromatid segregation (GO:0033048)2.73980713
112positive regulation of DNA-dependent DNA replication (GO:2000105)2.73820688
113regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.73611081
114regulation of DNA-dependent DNA replication (GO:0090329)2.73084163
115ATP-dependent chromatin remodeling (GO:0043044)2.73013651
116chromatin assembly (GO:0031497)2.72461890
117DNA replication (GO:0006260)2.71473780
118regulation of mitotic sister chromatid separation (GO:0010965)2.71258456
119regulation of mitotic sister chromatid segregation (GO:0033047)2.71258456
120regulation of sister chromatid segregation (GO:0033045)2.71258456
121mitotic spindle checkpoint (GO:0071174)2.70081451
122dosage compensation (GO:0007549)2.69725421
123base-excision repair (GO:0006284)2.69615545
124regulation of spindle organization (GO:0090224)2.69497961
125histone H3-K9 methylation (GO:0051567)2.69248109
126somatic hypermutation of immunoglobulin genes (GO:0016446)2.68121891
127somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68121891
128mitotic spindle assembly checkpoint (GO:0007094)2.68094656
129DNA double-strand break processing (GO:0000729)2.67434430
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64199379
131regulation of centriole replication (GO:0046599)2.62250427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.08463562
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.92988678
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.01331926
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.14598387
5TP63_19390658_ChIP-ChIP_HaCaT_Human2.56000469
6* E2F1_21310950_ChIP-Seq_MCF-7_Human2.45820440
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43009255
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31362237
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27255423
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26933426
11MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23992951
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20644205
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20586055
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.16611057
15E2F7_22180533_ChIP-Seq_HELA_Human12.3193797
16MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90465689
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.89682360
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89636850
19AR_21909140_ChIP-Seq_LNCAP_Human1.87426947
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80614404
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75943663
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72895710
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72886920
24FOXP3_21729870_ChIP-Seq_TREG_Human1.70291090
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70249470
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.67780412
27VDR_23849224_ChIP-Seq_CD4+_Human1.67041579
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66750510
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64281072
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61711043
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61024697
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55089586
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54980144
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54684308
35ELK1_19687146_ChIP-ChIP_HELA_Human1.54549462
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52176520
37CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51274767
38XRN2_22483619_ChIP-Seq_HELA_Human1.49767029
39CIITA_25753668_ChIP-Seq_RAJI_Human1.49207383
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45169088
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44441298
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.43369642
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41619184
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41562910
45* TTF2_22483619_ChIP-Seq_HELA_Human1.39500839
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.38016068
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36682485
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36618423
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36137558
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34280196
51CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33526797
52DCP1A_22483619_ChIP-Seq_HELA_Human1.32298028
53ZNF263_19887448_ChIP-Seq_K562_Human1.32282721
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.29136719
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28110022
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27825046
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26104349
58MYC_22102868_ChIP-Seq_BL_Human1.22222067
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22087835
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21443289
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21443289
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21443289
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21211583
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20878913
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20623829
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20247780
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19590727
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19125637
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19058630
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17292304
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16027623
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.15273136
73KDM5A_27292631_Chip-Seq_BREAST_Human1.15044286
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12584041
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12261398
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12101413
77SPI1_23547873_ChIP-Seq_NB4_Human1.08373671
78LXR_22292898_ChIP-Seq_THP-1_Human1.06050883
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05749235
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03861656
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03360186
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03141792
83NCOR1_26117541_ChIP-Seq_K562_Human1.02631877
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.02219342
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00926972
86* GABP_19822575_ChIP-Seq_HepG2_Human0.99318327
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98658469
88P68_20966046_ChIP-Seq_HELA_Human0.97109638
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97096483
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96481730
91STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95699173
92TCF7_22412390_ChIP-Seq_EML_Mouse0.95401227
93IRF1_19129219_ChIP-ChIP_H3396_Human0.92832251
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92181266
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91880265
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91815759
97FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91624640
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91403370
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90999525
100* VDR_21846776_ChIP-Seq_THP-1_Human0.90258575
101MAF_26560356_Chip-Seq_TH2_Human0.90065934
102* RACK7_27058665_Chip-Seq_MCF-7_Human0.90043992
103* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89150256
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87905861
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87804582
106TFEB_21752829_ChIP-Seq_HELA_Human0.87397646
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87260979
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.87148011
109SRF_21415370_ChIP-Seq_HL-1_Mouse0.86586849
110TET1_21451524_ChIP-Seq_MESCs_Mouse0.85761464
111MYC_18940864_ChIP-ChIP_HL60_Human0.85188689
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84667179
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84416362
114SCL_19346495_ChIP-Seq_HPC-7_Human0.83835877
115PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83444654
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82717422
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82465242
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81644911
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.79691106
120CHD1_26751641_Chip-Seq_LNCaP_Human0.79612221
121FOXP1_21924763_ChIP-Seq_HESCs_Human0.79092432
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79054281
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78831985
124EWS_26573619_Chip-Seq_HEK293_Human0.78699782
125MAF_26560356_Chip-Seq_TH1_Human0.78359957
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.78225792
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77471379
128PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76290441
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76251783
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76003433
131MYB_26560356_Chip-Seq_TH1_Human0.75406108
132STAT4_19710469_ChIP-ChIP_TH1__Mouse0.75119845
133UTX_26944678_Chip-Seq_JUKART_Human0.74646272
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73789366
135MYB_26560356_Chip-Seq_TH2_Human0.72620448
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72457024
137* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72016272
138* NANOG_16153702_ChIP-ChIP_HESCs_Human0.68820428
139PCGF2_27294783_Chip-Seq_NPCs_Mouse0.68684998
140TCF3_18692474_ChIP-Seq_MESCs_Mouse0.68180648
141RBPJ_22232070_ChIP-Seq_NCS_Mouse0.65641534
142PCGF2_27294783_Chip-Seq_ESCs_Mouse0.64980427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability4.19487391
2* MP0003111_abnormal_nucleus_morphology4.14486833
3MP0008057_abnormal_DNA_replication4.13523928
4MP0003693_abnormal_embryo_hatching4.02776906
5MP0003077_abnormal_cell_cycle3.28874974
6MP0008058_abnormal_DNA_repair3.24199023
7MP0004957_abnormal_blastocyst_morpholog2.71744252
8MP0003705_abnormal_hypodermis_morpholog2.52136081
9MP0002396_abnormal_hematopoietic_system2.49142046
10MP0008007_abnormal_cellular_replicative2.38165022
11MP0000569_abnormal_digit_pigmentation2.29405052
12MP0004185_abnormal_adipocyte_glucose2.10724003
13MP0008877_abnormal_DNA_methylation2.06543409
14MP0006292_abnormal_olfactory_placode2.03058410
15MP0008932_abnormal_embryonic_tissue1.99660592
16MP0000566_synostosis1.95925036
17MP0005174_abnormal_tail_pigmentation1.93579537
18MP0010307_abnormal_tumor_latency1.83511065
19MP0000490_abnormal_crypts_of1.76958076
20MP0001661_extended_life_span1.76731987
21MP0003121_genomic_imprinting1.72761635
22MP0000015_abnormal_ear_pigmentation1.69664727
23MP0000350_abnormal_cell_proliferation1.67233310
24MP0003941_abnormal_skin_development1.65205220
25MP0003136_yellow_coat_color1.60347358
26MP0003787_abnormal_imprinting1.54928251
27MP0004233_abnormal_muscle_weight1.51565829
28MP0004808_abnormal_hematopoietic_stem1.51530027
29MP0009672_abnormal_birth_weight1.45601744
30MP0001849_ear_inflammation1.45404501
31* MP0003786_premature_aging1.44394729
32MP0001730_embryonic_growth_arrest1.44347793
33MP0005171_absent_coat_pigmentation1.42455456
34MP0010352_gastrointestinal_tract_polyps1.37093712
35MP0009278_abnormal_bone_marrow1.32684114
36* MP0005380_embryogenesis_phenotype1.32335834
37* MP0001672_abnormal_embryogenesis/_devel1.32335834
38MP0002009_preneoplasia1.27736368
39MP0003890_abnormal_embryonic-extraembry1.26993670
40MP0003763_abnormal_thymus_physiology1.25021870
41MP0000313_abnormal_cell_death1.23628121
42MP0002085_abnormal_embryonic_tissue1.23241576
43MP0003943_abnormal_hepatobiliary_system1.21303044
44MP0001293_anophthalmia1.20876365
45MP0001188_hyperpigmentation1.20241810
46MP0002102_abnormal_ear_morphology1.19375956
47MP0003123_paternal_imprinting1.17296994
48MP0000703_abnormal_thymus_morphology1.16960001
49* MP0002398_abnormal_bone_marrow1.16094349
50MP0010030_abnormal_orbit_morphology1.15552557
51MP0001346_abnormal_lacrimal_gland1.15325283
52MP0004264_abnormal_extraembryonic_tissu1.13819685
53MP0004197_abnormal_fetal_growth/weight/1.13559726
54MP0002095_abnormal_skin_pigmentation1.13462510
55* MP0002210_abnormal_sex_determination1.11662311
56MP0001835_abnormal_antigen_presentation1.10549525
57MP0002877_abnormal_melanocyte_morpholog1.10333914
58MP0002019_abnormal_tumor_incidence1.10005412
59MP0002249_abnormal_larynx_morphology1.09643935
60* MP0003984_embryonic_growth_retardation1.09280129
61MP0001697_abnormal_embryo_size1.08151931
62MP0002084_abnormal_developmental_patter1.08045200
63MP0002938_white_spotting1.07913663
64MP0000678_abnormal_parathyroid_gland1.07462609
65MP0000003_abnormal_adipose_tissue1.07195565
66MP0002086_abnormal_extraembryonic_tissu1.07128302
67MP0005451_abnormal_body_composition1.06642598
68MP0005076_abnormal_cell_differentiation1.06331006
69* MP0002088_abnormal_embryonic_growth/wei1.05599976
70MP0002075_abnormal_coat/hair_pigmentati1.05030649
71* MP0002697_abnormal_eye_size1.04108648
72MP0001800_abnormal_humoral_immune1.03457600
73MP0002132_abnormal_respiratory_system1.00955252
74MP0002080_prenatal_lethality1.00398673
75MP0002722_abnormal_immune_system0.98778157
76MP0005075_abnormal_melanosome_morpholog0.98752234
77MP0003718_maternal_effect0.97883779
78MP0001545_abnormal_hematopoietic_system0.97488576
79MP0005397_hematopoietic_system_phenotyp0.97488576
80MP0001186_pigmentation_phenotype0.96694969
81MP0000537_abnormal_urethra_morphology0.96019813
82MP0003937_abnormal_limbs/digits/tail_de0.95674598
83MP0000689_abnormal_spleen_morphology0.94980446
84MP0002452_abnormal_antigen_presenting0.94431041
85MP0003567_abnormal_fetal_cardiomyocyte0.94264999
86MP0002277_abnormal_respiratory_mucosa0.94219979
87MP0004381_abnormal_hair_follicle0.93563082
88MP0003115_abnormal_respiratory_system0.93516123
89* MP0003699_abnormal_female_reproductive0.93457951
90MP0003878_abnormal_ear_physiology0.91699294
91MP0005377_hearing/vestibular/ear_phenot0.91699294
92MP0000371_diluted_coat_color0.91619670
93MP0000358_abnormal_cell_content/0.91229761
94* MP0001145_abnormal_male_reproductive0.87729972
95MP0002420_abnormal_adaptive_immunity0.86183276
96MP0001819_abnormal_immune_cell0.85873897
97MP0009333_abnormal_splenocyte_physiolog0.85782520
98MP0000716_abnormal_immune_system0.85156058
99* MP0002429_abnormal_blood_cell0.85023059
100* MP0005621_abnormal_cell_physiology0.83546376
101MP0001286_abnormal_eye_development0.83355661
102MP0000383_abnormal_hair_follicle0.83055645
103* MP0001929_abnormal_gametogenesis0.81237399
104MP0005671_abnormal_response_to0.81188703
105* MP0005384_cellular_phenotype0.79641878
106MP0000432_abnormal_head_morphology0.79297045
107MP0000858_altered_metastatic_potential0.79103815
108MP0005666_abnormal_adipose_tissue0.78595016
109MP0002970_abnormal_white_adipose0.77775425
110MP0002089_abnormal_postnatal_growth/wei0.77216201
111MP0005501_abnormal_skin_physiology0.77078395
112MP0006035_abnormal_mitochondrial_morpho0.75991638
113MP0002092_abnormal_eye_morphology0.75494685
114MP0005387_immune_system_phenotype0.75426737
115MP0001790_abnormal_immune_system0.75426737
116* MP0002161_abnormal_fertility/fecundity0.75275287
117MP0002723_abnormal_immune_serum0.74466231
118MP0009697_abnormal_copulation0.74104074
119* MP0003698_abnormal_male_reproductive0.74064591
120MP0000049_abnormal_middle_ear0.73485783
121MP0003942_abnormal_urinary_system0.73135851
122* MP0001119_abnormal_female_reproductive0.72699234
123MP0005360_urolithiasis0.72142683
124MP0002163_abnormal_gland_morphology0.72003252
125MP0004133_heterotaxia0.71624445
126* MP0000653_abnormal_sex_gland0.71389861
127MP0002111_abnormal_tail_morphology0.71063661
128MP0002405_respiratory_system_inflammati0.70113896
129MP0003861_abnormal_nervous_system0.69467684
130MP0005220_abnormal_exocrine_pancreas0.67783281
131MP0003938_abnormal_ear_development0.67345695
132MP0003315_abnormal_perineum_morphology0.65582943
133MP0003935_abnormal_craniofacial_develop0.65555002
134MP0009703_decreased_birth_body0.65541882
135MP0000428_abnormal_craniofacial_morphol0.61592902
136MP0002160_abnormal_reproductive_system0.59458010
137MP0000477_abnormal_intestine_morphology0.59349509
138MP0000627_abnormal_mammary_gland0.58480596
139MP0001348_abnormal_lacrimal_gland0.58251517
140MP0001873_stomach_inflammation0.55576769

Predicted human phenotypes

RankGene SetZ-score
1* Chromosomal breakage induced by crosslinking agents (HP:0003221)5.50048711
2* Chromsome breakage (HP:0040012)5.32159207
3Abnormality of cochlea (HP:0000375)4.06014638
4* Abnormality of chromosome stability (HP:0003220)3.55098375
5* Abnormality of the preputium (HP:0100587)3.34476188
6* Aplasia/Hypoplasia of the uvula (HP:0010293)3.29151735
7* Meckel diverticulum (HP:0002245)3.18493622
8Birth length less than 3rd percentile (HP:0003561)3.13688203
9* Abnormality of the ileum (HP:0001549)3.13652324
10* Ectopic kidney (HP:0000086)3.07641331
11Morphological abnormality of the inner ear (HP:0011390)2.97780057
12* Duplicated collecting system (HP:0000081)2.79971361
13Impulsivity (HP:0100710)2.69462127
14Selective tooth agenesis (HP:0001592)2.63315502
15Microvesicular hepatic steatosis (HP:0001414)2.63295956
16* Duodenal stenosis (HP:0100867)2.61217617
17* Small intestinal stenosis (HP:0012848)2.61217617
18* Myelodysplasia (HP:0002863)2.61061441
19Volvulus (HP:0002580)2.60567334
20Patellar aplasia (HP:0006443)2.60307261
21* Clubbing of toes (HP:0100760)2.56558286
22Medulloblastoma (HP:0002885)2.56304276
23Nephroblastoma (Wilms tumor) (HP:0002667)2.55984626
24Hyperacusis (HP:0010780)2.55452824
25* Abnormality of the renal collecting system (HP:0004742)2.54236395
26Abnormality of glycolysis (HP:0004366)2.50910163
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49853898
28Progressive muscle weakness (HP:0003323)2.48929608
2911 pairs of ribs (HP:0000878)2.48580040
30High anterior hairline (HP:0009890)2.46477021
31* Abnormality of the carotid arteries (HP:0005344)2.44413936
32* Absent radius (HP:0003974)2.41823309
33Prostate neoplasm (HP:0100787)2.38778513
34Progressive external ophthalmoplegia (HP:0000590)2.37549108
35Embryonal renal neoplasm (HP:0011794)2.35917864
36* Bone marrow hypocellularity (HP:0005528)2.35637336
37Aplasia/Hypoplasia of the patella (HP:0006498)2.35486668
38* Sloping forehead (HP:0000340)2.33728171
39Broad distal phalanx of finger (HP:0009836)2.29190074
40* Absent forearm bone (HP:0003953)2.27926390
41* Aplasia involving forearm bones (HP:0009822)2.27926390
42* Abnormality of DNA repair (HP:0003254)2.25873752
43Breast hypoplasia (HP:0003187)2.24461845
44Abnormal number of incisors (HP:0011064)2.21199720
45Facial hemangioma (HP:0000329)2.16866723
46Abnormality of the fingertips (HP:0001211)2.16550372
47Ulnar bowing (HP:0003031)2.15579508
48Premature graying of hair (HP:0002216)2.14571860
49Flattened epiphyses (HP:0003071)2.11763826
50Increased serum pyruvate (HP:0003542)2.11561189
51Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10737560
52Increased nuchal translucency (HP:0010880)2.10663351
53* Abnormality of the duodenum (HP:0002246)2.09005585
54Trigonocephaly (HP:0000243)2.08832513
55Optic nerve coloboma (HP:0000588)2.07983181
56Urethral obstruction (HP:0000796)2.05781327
57* Short thumb (HP:0009778)2.04461887
58* Absent thumb (HP:0009777)2.04058945
59* Reticulocytopenia (HP:0001896)2.03159664
60Asplenia (HP:0001746)2.02242831
61* Tracheoesophageal fistula (HP:0002575)2.01709216
62* Triphalangeal thumb (HP:0001199)2.01086559
63Abnormality of the calcaneus (HP:0008364)2.00406546
64Small epiphyses (HP:0010585)1.97502004
65Homocystinuria (HP:0002156)1.97113992
66Abnormality of homocysteine metabolism (HP:0010919)1.97113992
67Lip pit (HP:0100267)1.95450504
68Insomnia (HP:0100785)1.93236756
69Agnosia (HP:0010524)1.92820249
70* Duplication of thumb phalanx (HP:0009942)1.92661506
71Heterotopia (HP:0002282)1.92593065
72Overlapping toe (HP:0001845)1.90917872
73Irregular epiphyses (HP:0010582)1.90891711
74Rough bone trabeculation (HP:0100670)1.90477170
75Abnormal lung lobation (HP:0002101)1.89414493
76Anal stenosis (HP:0002025)1.87352971
77Abnormality of the labia minora (HP:0012880)1.86316916
78Aplasia/Hypoplasia of the spleen (HP:0010451)1.86082715
79Deep philtrum (HP:0002002)1.84963658
80* Arteriovenous malformation (HP:0100026)1.84926150
81Septate vagina (HP:0001153)1.84778168
82Deviation of the thumb (HP:0009603)1.83230664
83Prominent nose (HP:0000448)1.82830865
84Proximal placement of thumb (HP:0009623)1.82684447
85Embryonal neoplasm (HP:0002898)1.82536111
86Abnormality of the phalanges of the hallux (HP:0010057)1.82009666
87Lymphoma (HP:0002665)1.81166674
88Ependymoma (HP:0002888)1.79544275
89Vaginal fistula (HP:0004320)1.78353071
90Dislocated radial head (HP:0003083)1.78144239
91* Abnormality of reticulocytes (HP:0004312)1.77669873
92Obsessive-compulsive behavior (HP:0000722)1.77620387
93Sandal gap (HP:0001852)1.76323537
94Skull defect (HP:0001362)1.75929410
95Supernumerary spleens (HP:0009799)1.75271855
96Poikiloderma (HP:0001029)1.74478055
97Recurrent abscess formation (HP:0002722)1.74241842
98Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74167962
99Mesomelia (HP:0003027)1.74136725
100* Leukopenia (HP:0001882)1.73518381
101IgM deficiency (HP:0002850)1.73217808
102Rectovaginal fistula (HP:0000143)1.73145769
103Rectal fistula (HP:0100590)1.73145769
104Septo-optic dysplasia (HP:0100842)1.73131051
105Abdominal situs inversus (HP:0003363)1.72988959
106Abnormality of abdominal situs (HP:0011620)1.72988959
107Syringomyelia (HP:0003396)1.72790699
108Spinal cord lesions (HP:0100561)1.72790699
109Hypopigmentation of the fundus (HP:0007894)1.72742117
110* Choanal atresia (HP:0000453)1.72559480
111Squamous cell carcinoma (HP:0002860)1.71797601
112* Horseshoe kidney (HP:0000085)1.71459281
113High pitched voice (HP:0001620)1.71275038
114Abnormality of the incisor (HP:0000676)1.70609545
115Abnormal trabecular bone morphology (HP:0100671)1.69449062
116Limited elbow extension (HP:0001377)1.69342136
117Intestinal fistula (HP:0100819)1.69250683
118Rhabdomyosarcoma (HP:0002859)1.69148407
119Short 4th metacarpal (HP:0010044)1.68899548
120Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68899548
121Aplastic anemia (HP:0001915)1.67913752
122Ragged-red muscle fibers (HP:0003200)1.67658651
123Capillary hemangiomas (HP:0005306)1.67469181
124Abnormality of the umbilical cord (HP:0010881)1.67304129
125Abnormality of the prostate (HP:0008775)1.67053147
126Disproportionate tall stature (HP:0001519)1.66054541
127Aplasia cutis congenita (HP:0001057)1.63257320
128Long eyelashes (HP:0000527)1.62618032
129Recurrent pneumonia (HP:0006532)1.61228095
130Abnormality of chromosome segregation (HP:0002916)1.60979194
131* Cafe-au-lait spot (HP:0000957)1.60521426
132Obstructive lung disease (HP:0006536)1.59333316
133Chronic obstructive pulmonary disease (HP:0006510)1.59333316
134Absent epiphyses (HP:0010577)1.59114923
135Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59114923
136Acute lymphatic leukemia (HP:0006721)1.58858736
137Missing ribs (HP:0000921)1.58028186
138Neoplasm of the oral cavity (HP:0100649)1.57712568
139Upper limb muscle weakness (HP:0003484)1.56318988
140Microtia (HP:0008551)1.55201765
141Supernumerary bones of the axial skeleton (HP:0009144)1.54065190
142Cheilitis (HP:0100825)1.51812487
143Ectropion (HP:0000656)1.50956313
144IgA deficiency (HP:0002720)1.50923274
145Rib fusion (HP:0000902)1.50559210
146Intestinal atresia (HP:0011100)1.49384191
147Glioma (HP:0009733)1.48797766
148Cleft eyelid (HP:0000625)1.48767633
149Atresia of the external auditory canal (HP:0000413)1.47875926
150Acute myeloid leukemia (HP:0004808)1.47291715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.25883059
2CDK123.44500573
3SMG13.38687657
4TRIB33.10157722
5NEK22.83373013
6ZAK2.77087099
7SRPK12.76975709
8BUB12.72709397
9BRD42.71927945
10WEE12.69437227
11TTK2.60802551
12ICK2.43923004
13MKNK22.13675766
14MKNK12.13403090
15* ATR2.11717357
16TLK12.01279147
17TAOK31.97333543
18STK161.96984390
19CDK71.88851831
20CHEK21.87356463
21PLK11.82401912
22PLK41.81149720
23STK41.73570480
24NEK11.70954133
25CLK11.69896229
26EPHA21.61772917
27AURKB1.61589684
28VRK11.58460081
29VRK21.57951507
30IRAK41.56549593
31MST1R1.54548617
32EEF2K1.50892401
33CDK41.50471507
34BCKDK1.46117789
35YES11.43669138
36PASK1.41952124
37CHEK11.41425785
38EIF2AK21.41182475
39CAMK1D1.39734810
40RPS6KB21.38738319
41MAP3K141.35732449
42SIK31.34137426
43STK101.27984104
44PLK31.27039847
45CAMK1G1.25806411
46BRSK21.23784396
47TESK21.22995120
48ATM1.19930454
49AKT31.19071478
50MAP4K11.14661776
51EIF2AK11.13962434
52PIM11.13435816
53TSSK61.12127153
54MAP2K31.11592519
55PKN21.10575666
56TXK1.10287433
57CDK81.09167539
58MAPK111.07299757
59ACVR1B1.05186676
60SIK21.03924333
61PNCK1.00799232
62IRAK31.00653398
63SCYL20.96801479
64STK30.94305483
65MAP3K80.93534612
66MARK30.91819219
67DYRK30.88783787
68STK38L0.86435370
69CDK20.84756738
70TRPM70.84414060
71TEC0.84366710
72FGFR40.83661162
73BTK0.83119273
74SIK10.81077779
75AURKA0.79196229
76TAF10.77289769
77CDK60.76883476
78CDK10.76375322
79ERN10.71766717
80BLK0.70381125
81CCNB10.69923012
82RPS6KA40.69903555
83CDK90.69209332
84JAK30.63872882
85NUAK10.63018365
86RPS6KA50.62835752
87MAP3K100.62323764
88CHUK0.61632327
89MELK0.60241172
90TNK20.59830308
91BRAF0.59745682
92PAK40.59645060
93MET0.56644317
94TYRO30.55621528
95IKBKB0.55576760
96PBK0.54008188
97AKT20.53555036
98NME10.52225581
99MST40.51105032
100EIF2AK30.50687944
101CSNK2A10.50597492
102CSNK2A20.50363568
103ALK0.49535150
104PRKDC0.48513080
105BMX0.48481965
106BRSK10.48100581
107MAPK140.47483636
108LYN0.46463254
109* AKT10.45507480
110LATS10.45262127
111WNK40.44804257
112PDK20.43595798
113PTK60.43542715
114CSNK1D0.42819786
115CDK30.42587962
116CSF1R0.42090250
117GRK10.39103480
118KSR20.38391095
119KIT0.38098895
120PRPF4B0.36757470
121HCK0.35947826
122MTOR0.35482239
123TGFBR10.34430545
124GSK3B0.34266651
125PAK10.33638646
126MAPK10.33495637
127LCK0.33382702
128NME20.33241814
129ERBB30.33102173
130RPS6KA10.32493184
131RPS6KC10.31831558
132IRAK20.28743758
133MAPKAPK20.27003745
134CSNK1E0.26060557
135KDR0.25788911
136RPS6KB10.25346600

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.45118642
2Mismatch repair_Homo sapiens_hsa034303.89857943
3Homologous recombination_Homo sapiens_hsa034403.44611028
4* Fanconi anemia pathway_Homo sapiens_hsa034603.11023258
5Base excision repair_Homo sapiens_hsa034102.95776072
6Cell cycle_Homo sapiens_hsa041102.72114893
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64366673
8Spliceosome_Homo sapiens_hsa030402.62817387
9Nucleotide excision repair_Homo sapiens_hsa034202.60164260
10Non-homologous end-joining_Homo sapiens_hsa034502.58698556
11One carbon pool by folate_Homo sapiens_hsa006702.52724152
12RNA transport_Homo sapiens_hsa030132.32694433
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16005578
14Biosynthesis of amino acids_Homo sapiens_hsa012301.93105996
15RNA polymerase_Homo sapiens_hsa030201.92586707
16mRNA surveillance pathway_Homo sapiens_hsa030151.79063738
17Sulfur relay system_Homo sapiens_hsa041221.76875090
18RNA degradation_Homo sapiens_hsa030181.74240020
19Pyrimidine metabolism_Homo sapiens_hsa002401.70403202
20Basal transcription factors_Homo sapiens_hsa030221.66916093
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62291729
22p53 signaling pathway_Homo sapiens_hsa041151.59507417
23Systemic lupus erythematosus_Homo sapiens_hsa053221.53978823
24Ribosome_Homo sapiens_hsa030101.50799766
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.40616796
26Herpes simplex infection_Homo sapiens_hsa051681.35591361
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34983500
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.32405663
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29495149
30Primary immunodeficiency_Homo sapiens_hsa053401.28484829
31Viral carcinogenesis_Homo sapiens_hsa052031.17734467
32Bladder cancer_Homo sapiens_hsa052191.14562893
33Pentose phosphate pathway_Homo sapiens_hsa000301.12133870
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10532129
35Epstein-Barr virus infection_Homo sapiens_hsa051691.07929733
36Measles_Homo sapiens_hsa051621.06812533
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06593183
38Fructose and mannose metabolism_Homo sapiens_hsa000511.05162195
39MicroRNAs in cancer_Homo sapiens_hsa052061.04539745
40Proteasome_Homo sapiens_hsa030501.04387364
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04261404
42Galactose metabolism_Homo sapiens_hsa000521.03894794
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.00950003
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.99336329
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.98943907
46Small cell lung cancer_Homo sapiens_hsa052220.98439877
47Hematopoietic cell lineage_Homo sapiens_hsa046400.98389740
48Thyroid cancer_Homo sapiens_hsa052160.98009440
49HTLV-I infection_Homo sapiens_hsa051660.97912884
50Selenocompound metabolism_Homo sapiens_hsa004500.97124954
51Purine metabolism_Homo sapiens_hsa002300.93713005
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93594758
53Carbon metabolism_Homo sapiens_hsa012000.91409368
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91352205
55Vitamin B6 metabolism_Homo sapiens_hsa007500.88913362
56Notch signaling pathway_Homo sapiens_hsa043300.77207567
57Apoptosis_Homo sapiens_hsa042100.76701709
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76317536
59Influenza A_Homo sapiens_hsa051640.74979021
60Pyruvate metabolism_Homo sapiens_hsa006200.74307249
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73760707
62Lysine degradation_Homo sapiens_hsa003100.73401608
63Hepatitis B_Homo sapiens_hsa051610.70963552
64Antigen processing and presentation_Homo sapiens_hsa046120.70860071
65Autoimmune thyroid disease_Homo sapiens_hsa053200.70083452
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69432790
67Folate biosynthesis_Homo sapiens_hsa007900.68485017
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68445537
69Asthma_Homo sapiens_hsa053100.68146881
70Allograft rejection_Homo sapiens_hsa053300.67902793
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66592566
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66104141
73Leishmaniasis_Homo sapiens_hsa051400.65229207
74Basal cell carcinoma_Homo sapiens_hsa052170.64549130
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62732402
76Legionellosis_Homo sapiens_hsa051340.61650466
77Chronic myeloid leukemia_Homo sapiens_hsa052200.61575742
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60077514
79B cell receptor signaling pathway_Homo sapiens_hsa046620.59963548
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59405825
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58309012
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58292689
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57336341
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56197868
85Viral myocarditis_Homo sapiens_hsa054160.55594513
86Melanoma_Homo sapiens_hsa052180.52980936
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52486023
88Alcoholism_Homo sapiens_hsa050340.52341321
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.51845028
90Prostate cancer_Homo sapiens_hsa052150.51826682
91Colorectal cancer_Homo sapiens_hsa052100.50385399
92Pathways in cancer_Homo sapiens_hsa052000.49347204
93Oocyte meiosis_Homo sapiens_hsa041140.48215099
94Vitamin digestion and absorption_Homo sapiens_hsa049770.47843291
95Glioma_Homo sapiens_hsa052140.47573295
96Graft-versus-host disease_Homo sapiens_hsa053320.47481844
97Arginine biosynthesis_Homo sapiens_hsa002200.47405397
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47369646
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47145615
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46680499
101Other glycan degradation_Homo sapiens_hsa005110.45088751
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.44458853
103Adherens junction_Homo sapiens_hsa045200.44292543
104TGF-beta signaling pathway_Homo sapiens_hsa043500.44153599
105Arachidonic acid metabolism_Homo sapiens_hsa005900.43435448
106Pancreatic cancer_Homo sapiens_hsa052120.42882017
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40772374
108Acute myeloid leukemia_Homo sapiens_hsa052210.40750050
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39959770
110Shigellosis_Homo sapiens_hsa051310.39898097
111Osteoclast differentiation_Homo sapiens_hsa043800.38635870
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38606359
113TNF signaling pathway_Homo sapiens_hsa046680.37889839
114Hippo signaling pathway_Homo sapiens_hsa043900.37888802
115T cell receptor signaling pathway_Homo sapiens_hsa046600.35271016
116Toxoplasmosis_Homo sapiens_hsa051450.35270399
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34218493
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33946307
119Sphingolipid metabolism_Homo sapiens_hsa006000.32204181
120Fatty acid biosynthesis_Homo sapiens_hsa000610.32143999
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32057010
122Endometrial cancer_Homo sapiens_hsa052130.31973357
123Hepatitis C_Homo sapiens_hsa051600.30148762
124Tuberculosis_Homo sapiens_hsa051520.29972474
125Non-small cell lung cancer_Homo sapiens_hsa052230.29426692
126N-Glycan biosynthesis_Homo sapiens_hsa005100.29276339
127mTOR signaling pathway_Homo sapiens_hsa041500.28538811
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28234508
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28046185
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27983289
131Chemokine signaling pathway_Homo sapiens_hsa040620.27671308
132FoxO signaling pathway_Homo sapiens_hsa040680.27572853
133Wnt signaling pathway_Homo sapiens_hsa043100.26863609
134VEGF signaling pathway_Homo sapiens_hsa043700.26831651
135Steroid biosynthesis_Homo sapiens_hsa001000.25593947
136AMPK signaling pathway_Homo sapiens_hsa041520.25578565
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21908966
138ErbB signaling pathway_Homo sapiens_hsa040120.20349722
139Insulin signaling pathway_Homo sapiens_hsa049100.19915368
140Choline metabolism in cancer_Homo sapiens_hsa052310.17588431
141HIF-1 signaling pathway_Homo sapiens_hsa040660.12926642
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.12009214

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