FAM9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a gene family which arose through duplication on the X chromosome. The encoded protein may be localized to the nucleus as the protein contains several nuclear localization signals, and has similarity to a synaptonemal complex protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.22465210
2response to pheromone (GO:0019236)4.64151181
3piRNA metabolic process (GO:0034587)4.00162910
4water-soluble vitamin biosynthetic process (GO:0042364)3.96841258
5tryptophan catabolic process (GO:0006569)3.72723153
6indole-containing compound catabolic process (GO:0042436)3.72723153
7indolalkylamine catabolic process (GO:0046218)3.72723153
8DNA deamination (GO:0045006)3.64171553
9platelet dense granule organization (GO:0060155)3.59711995
10fucose catabolic process (GO:0019317)3.57888781
11L-fucose metabolic process (GO:0042354)3.57888781
12L-fucose catabolic process (GO:0042355)3.57888781
13detection of light stimulus involved in visual perception (GO:0050908)3.56377621
14detection of light stimulus involved in sensory perception (GO:0050962)3.56377621
15detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.46048918
16axoneme assembly (GO:0035082)3.44406000
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.43086996
18kynurenine metabolic process (GO:0070189)3.39516790
19sulfation (GO:0051923)3.39442715
20nonmotile primary cilium assembly (GO:0035058)3.38833270
21regulation of cilium movement (GO:0003352)3.37405713
22respiratory chain complex IV assembly (GO:0008535)3.37009942
23protein complex biogenesis (GO:0070271)3.34986001
24transmission of nerve impulse (GO:0019226)3.33555559
25indolalkylamine metabolic process (GO:0006586)3.30350734
26epithelial cilium movement (GO:0003351)3.27725189
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.24570488
28NADH dehydrogenase complex assembly (GO:0010257)3.24570488
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24570488
30synapsis (GO:0007129)3.20938057
31DNA methylation involved in gamete generation (GO:0043046)3.19216828
32rRNA catabolic process (GO:0016075)3.12678576
33negative regulation of telomere maintenance (GO:0032205)3.11366162
34negative regulation of mast cell activation (GO:0033004)3.09179164
35cellular ketone body metabolic process (GO:0046950)3.04846112
36tryptophan metabolic process (GO:0006568)3.00468231
37mitochondrial respiratory chain complex assembly (GO:0033108)2.97430207
38cytochrome complex assembly (GO:0017004)2.95263621
39dopamine transport (GO:0015872)2.94866312
40male meiosis I (GO:0007141)2.90405645
41regulation of rhodopsin mediated signaling pathway (GO:0022400)2.88510635
42rhodopsin mediated signaling pathway (GO:0016056)2.84160165
43negative regulation of transcription regulatory region DNA binding (GO:2000678)2.82358451
44protein polyglutamylation (GO:0018095)2.80504831
45protein-cofactor linkage (GO:0018065)2.80161971
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77835461
47ubiquinone biosynthetic process (GO:0006744)2.77527609
48oxidative demethylation (GO:0070989)2.77073110
49protein K11-linked deubiquitination (GO:0035871)2.76539738
50S-adenosylmethionine metabolic process (GO:0046500)2.69573831
51kidney morphogenesis (GO:0060993)2.69318762
52ketone body metabolic process (GO:1902224)2.69018308
53photoreceptor cell maintenance (GO:0045494)2.68814421
54male meiosis (GO:0007140)2.68760110
55cornea development in camera-type eye (GO:0061303)2.68487107
56reciprocal meiotic recombination (GO:0007131)2.68024539
57reciprocal DNA recombination (GO:0035825)2.68024539
58regulation of action potential (GO:0098900)2.67537364
59protein localization to cilium (GO:0061512)2.66086129
60regulation of meiosis I (GO:0060631)2.64321521
61negative regulation of synaptic transmission, GABAergic (GO:0032229)2.63945324
62neuronal action potential (GO:0019228)2.63708857
63amine catabolic process (GO:0009310)2.63114982
64cellular biogenic amine catabolic process (GO:0042402)2.63114982
65retinal cone cell development (GO:0046549)2.63042079
66parturition (GO:0007567)2.61109674
67gamma-aminobutyric acid transport (GO:0015812)2.60452105
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.60035791
69ubiquinone metabolic process (GO:0006743)2.59770665
70replication fork processing (GO:0031297)2.58993698
71indole-containing compound metabolic process (GO:0042430)2.58945360
72cilium movement (GO:0003341)2.58935132
73somite development (GO:0061053)2.56974083
74positive regulation of fatty acid transport (GO:2000193)2.56840451
75recombinational repair (GO:0000725)2.56675239
76double-strand break repair via homologous recombination (GO:0000724)2.56373317
77cilium morphogenesis (GO:0060271)2.53514570
78multicellular organism reproduction (GO:0032504)2.52515812
79synaptic transmission, cholinergic (GO:0007271)2.52229176
80reflex (GO:0060004)2.51570148
81behavioral response to ethanol (GO:0048149)2.49161560
82negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49072275
83preassembly of GPI anchor in ER membrane (GO:0016254)2.47904467
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46932315
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.44431628
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.44431628
87cilium organization (GO:0044782)2.44196058
88neural tube formation (GO:0001841)2.43836778
89glycerophospholipid catabolic process (GO:0046475)2.43180495
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.41150790
91membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40487898
92photoreceptor cell development (GO:0042461)2.40206017
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.39877588
94benzene-containing compound metabolic process (GO:0042537)2.39403509
95phosphatidylinositol acyl-chain remodeling (GO:0036149)2.38070840
96tachykinin receptor signaling pathway (GO:0007217)2.37930337
97positive regulation of meiosis (GO:0045836)2.37564309
98regulation of microtubule-based movement (GO:0060632)2.36663948
99proline transport (GO:0015824)2.36464793
100cilium assembly (GO:0042384)2.35756895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.82976752
2VDR_22108803_ChIP-Seq_LS180_Human3.40793771
3EZH2_22144423_ChIP-Seq_EOC_Human3.40543762
4GBX2_23144817_ChIP-Seq_PC3_Human2.91870277
5IGF1R_20145208_ChIP-Seq_DFB_Human2.84823913
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67926786
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64949160
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51854419
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.28198165
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21838927
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20812760
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03896753
13* EWS_26573619_Chip-Seq_HEK293_Human2.03207863
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99902798
15P300_19829295_ChIP-Seq_ESCs_Human1.98126895
16FUS_26573619_Chip-Seq_HEK293_Human1.96971887
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90024752
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87342152
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85995667
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85138819
21ER_23166858_ChIP-Seq_MCF-7_Human1.84246600
22TAF15_26573619_Chip-Seq_HEK293_Human1.77638200
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77581279
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76831946
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74884802
26TP53_22573176_ChIP-Seq_HFKS_Human1.67840181
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.59506649
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56348398
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56345228
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56141465
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.54490528
32BCAT_22108803_ChIP-Seq_LS180_Human1.53297709
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52354990
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51816148
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51322944
36CBP_20019798_ChIP-Seq_JUKART_Human1.51322944
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.51216643
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.48463984
39AR_25329375_ChIP-Seq_VCAP_Human1.46164441
40STAT3_23295773_ChIP-Seq_U87_Human1.44864521
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44688268
42* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44415463
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.44131817
44MYC_18940864_ChIP-ChIP_HL60_Human1.41706048
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39802917
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.39332497
47SOX2_19829295_ChIP-Seq_ESCs_Human1.39046188
48NANOG_19829295_ChIP-Seq_ESCs_Human1.39046188
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.38662885
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37100193
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.37100193
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36444151
53TCF4_23295773_ChIP-Seq_U87_Human1.36414485
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34702159
55RNF2_27304074_Chip-Seq_NSC_Mouse1.34415772
56REST_21632747_ChIP-Seq_MESCs_Mouse1.33827553
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32640396
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31864927
59IRF1_19129219_ChIP-ChIP_H3396_Human1.30663639
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26208970
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25980121
62* TCF4_22108803_ChIP-Seq_LS180_Human1.24820550
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24256871
64NCOR_22424771_ChIP-Seq_293T_Human1.23836895
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23542061
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.23434557
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.23065370
68AR_20517297_ChIP-Seq_VCAP_Human1.21628360
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.21395701
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.21197160
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19911354
72* RUNX2_22187159_ChIP-Seq_PCA_Human1.19647896
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18195188
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17544431
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15870733
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.14324449
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13971129
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13971129
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11336887
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.09292299
81ELK1_19687146_ChIP-ChIP_HELA_Human1.08951925
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08854551
83HOXB7_26014856_ChIP-Seq_BT474_Human1.08295689
84MYC_19829295_ChIP-Seq_ESCs_Human1.08269146
85VDR_23849224_ChIP-Seq_CD4+_Human1.06752984
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.06602985
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05730497
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03881609
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03593989
90FOXH1_21741376_ChIP-Seq_EPCs_Human1.02396157
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.01732703
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.99894294
93EZH2_27304074_Chip-Seq_ESCs_Mouse0.99547980
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99019364
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98730254
96HTT_18923047_ChIP-ChIP_STHdh_Human0.98506521
97AR_21572438_ChIP-Seq_LNCaP_Human0.96958042
98REST_18959480_ChIP-ChIP_MESCs_Mouse0.96596530
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95928724
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95692562

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.10664990
2MP0002102_abnormal_ear_morphology2.84191038
3MP0008877_abnormal_DNA_methylation2.71550267
4MP0005551_abnormal_eye_electrophysiolog2.62443461
5MP0003646_muscle_fatigue2.58227342
6MP0002837_dystrophic_cardiac_calcinosis2.37865409
7MP0005646_abnormal_pituitary_gland2.26266435
8MP0001968_abnormal_touch/_nociception2.24650004
9MP0003011_delayed_dark_adaptation2.17331429
10MP0003136_yellow_coat_color2.15864761
11MP0001986_abnormal_taste_sensitivity2.10904234
12MP0008875_abnormal_xenobiotic_pharmacok2.08495568
13MP0006292_abnormal_olfactory_placode2.03053608
14MP0005645_abnormal_hypothalamus_physiol2.00926144
15MP0006072_abnormal_retinal_apoptosis1.94620169
16MP0008872_abnormal_physiological_respon1.92496678
17MP0003880_abnormal_central_pattern1.89114084
18MP0002736_abnormal_nociception_after1.87803683
19MP0004147_increased_porphyrin_level1.86022320
20MP0002638_abnormal_pupillary_reflex1.85606463
21MP0009745_abnormal_behavioral_response1.84046885
22MP0001529_abnormal_vocalization1.80430643
23MP0005253_abnormal_eye_physiology1.72620314
24MP0002876_abnormal_thyroid_physiology1.71523187
25MP0002272_abnormal_nervous_system1.69032958
26MP0004142_abnormal_muscle_tone1.68642129
27MP0002160_abnormal_reproductive_system1.68066044
28MP0009046_muscle_twitch1.64062411
29MP0003787_abnormal_imprinting1.63648775
30MP0002653_abnormal_ependyma_morphology1.63145670
31MP0004885_abnormal_endolymph1.62516579
32MP0004133_heterotaxia1.61636728
33MP0000569_abnormal_digit_pigmentation1.61557982
34MP0002138_abnormal_hepatobiliary_system1.59135780
35MP0001485_abnormal_pinna_reflex1.57472978
36MP0004145_abnormal_muscle_electrophysio1.56730802
37MP0006276_abnormal_autonomic_nervous1.55542409
38MP0005389_reproductive_system_phenotype1.55274236
39MP0004043_abnormal_pH_regulation1.47250989
40MP0001501_abnormal_sleep_pattern1.44477515
41MP0003283_abnormal_digestive_organ1.42909636
42MP0000372_irregular_coat_pigmentation1.41955266
43MP0000631_abnormal_neuroendocrine_gland1.39250492
44MP0005423_abnormal_somatic_nervous1.36387561
45MP0000427_abnormal_hair_cycle1.36191517
46MP0001984_abnormal_olfaction1.35493635
47MP0001486_abnormal_startle_reflex1.34788876
48MP0002735_abnormal_chemical_nociception1.34296584
49MP0002938_white_spotting1.33576812
50MP0008995_early_reproductive_senescence1.27395321
51MP0002733_abnormal_thermal_nociception1.25223685
52MP0001970_abnormal_pain_threshold1.21549187
53MP0002557_abnormal_social/conspecific_i1.20298804
54MP0001919_abnormal_reproductive_system1.19998683
55MP0002572_abnormal_emotion/affect_behav1.19024565
56MP0002064_seizures1.16354234
57MP0004742_abnormal_vestibular_system1.15600401
58MP0005386_behavior/neurological_phenoty1.12154758
59MP0004924_abnormal_behavior1.12154758
60MP0003718_maternal_effect1.11461845
61MP0005410_abnormal_fertilization1.08893400
62MP0005085_abnormal_gallbladder_physiolo1.05059638
63MP0002163_abnormal_gland_morphology1.02420783
64MP0000383_abnormal_hair_follicle1.01574534
65MP0005195_abnormal_posterior_eye1.01067233
66MP0003698_abnormal_male_reproductive1.01007615
67MP0001905_abnormal_dopamine_level1.00992861
68MP0003252_abnormal_bile_duct1.00841973
69MP0002928_abnormal_bile_duct0.99750457
70MP0002734_abnormal_mechanical_nocicepti0.99621719
71MP0001764_abnormal_homeostasis0.99598055
72MP0008058_abnormal_DNA_repair0.99240004
73MP0005084_abnormal_gallbladder_morpholo0.98999996
74MP0003635_abnormal_synaptic_transmissio0.96240295
75MP0001929_abnormal_gametogenesis0.95893259
76MP0010386_abnormal_urinary_bladder0.95275924
77MP0002254_reproductive_system_inflammat0.94569711
78MP0002210_abnormal_sex_determination0.94081207
79MP0003122_maternal_imprinting0.93819164
80MP0002067_abnormal_sensory_capabilities0.92994734
81MP0005174_abnormal_tail_pigmentation0.91321444
82MP0005167_abnormal_blood-brain_barrier0.91185620
83MP0002234_abnormal_pharynx_morphology0.90902984
84MP0008775_abnormal_heart_ventricle0.90843649
85MP0002063_abnormal_learning/memory/cond0.90492124
86MP0005379_endocrine/exocrine_gland_phen0.90366721
87MP0002752_abnormal_somatic_nervous0.88438378
88MP0002277_abnormal_respiratory_mucosa0.84883185
89MP0000026_abnormal_inner_ear0.84051370
90MP0008789_abnormal_olfactory_epithelium0.83923474
91MP0005187_abnormal_penis_morphology0.83610508
92MP0003890_abnormal_embryonic-extraembry0.83591294
93MP0001963_abnormal_hearing_physiology0.83495410
94MP0001502_abnormal_circadian_rhythm0.82264914
95MP0003121_genomic_imprinting0.80687856
96MP0002095_abnormal_skin_pigmentation0.79614102
97MP0000647_abnormal_sebaceous_gland0.79337715
98MP0005332_abnormal_amino_acid0.79322464
99MP0000653_abnormal_sex_gland0.78972008
100MP0002229_neurodegeneration0.77983906

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.18857868
2Congenital stationary night blindness (HP:0007642)4.05296307
3True hermaphroditism (HP:0010459)3.86992747
4Pancreatic fibrosis (HP:0100732)3.83878022
5Molar tooth sign on MRI (HP:0002419)3.79442997
6Abnormality of midbrain morphology (HP:0002418)3.79442997
7Nephronophthisis (HP:0000090)3.57011677
8Abnormal rod and cone electroretinograms (HP:0008323)3.40600321
9Abnormality of the renal cortex (HP:0011035)3.22543102
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.15096369
11Abnormality of the renal medulla (HP:0100957)3.07417358
12Type II lissencephaly (HP:0007260)3.06234657
13Medial flaring of the eyebrow (HP:0010747)3.04255592
14Attenuation of retinal blood vessels (HP:0007843)3.03856005
15Decreased central vision (HP:0007663)2.75810938
16Abolished electroretinogram (ERG) (HP:0000550)2.74982405
17Hypothermia (HP:0002045)2.68904943
18Renal cortical cysts (HP:0000803)2.66626539
19Tubular atrophy (HP:0000092)2.60334806
20Pendular nystagmus (HP:0012043)2.58882129
21Abnormal drinking behavior (HP:0030082)2.55595801
22Polydipsia (HP:0001959)2.55595801
23Acute necrotizing encephalopathy (HP:0006965)2.54178487
24Mitochondrial inheritance (HP:0001427)2.53413987
25Increased corneal curvature (HP:0100692)2.52326385
26Keratoconus (HP:0000563)2.52326385
27Gait imbalance (HP:0002141)2.52154044
28Cystic liver disease (HP:0006706)2.50285089
29Increased CSF lactate (HP:0002490)2.48589556
30Methylmalonic acidemia (HP:0002912)2.47750757
31Chronic hepatic failure (HP:0100626)2.47251883
32Congenital, generalized hypertrichosis (HP:0004540)2.45186418
33Congenital primary aphakia (HP:0007707)2.44219933
34Hyperventilation (HP:0002883)2.39913648
35Anencephaly (HP:0002323)2.36795546
36Lipid accumulation in hepatocytes (HP:0006561)2.31040741
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28211893
38Abnormality of alanine metabolism (HP:0010916)2.28211893
39Hyperalaninemia (HP:0003348)2.28211893
40Large for gestational age (HP:0001520)2.27153358
41Nephrogenic diabetes insipidus (HP:0009806)2.25569126
42Increased hepatocellular lipid droplets (HP:0006565)2.25560159
43Progressive macrocephaly (HP:0004481)2.25185053
44Sclerocornea (HP:0000647)2.24651931
45Abnormality of the labia minora (HP:0012880)2.23511628
46Bony spicule pigmentary retinopathy (HP:0007737)2.23060614
47Abnormal mitochondria in muscle tissue (HP:0008316)2.18650158
48Acute encephalopathy (HP:0006846)2.17110327
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.15119625
50Inability to walk (HP:0002540)2.13410291
51Hepatocellular necrosis (HP:0001404)2.13401613
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.11719320
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11300810
54Colon cancer (HP:0003003)2.11083747
55Genital tract atresia (HP:0001827)2.10482462
56Polyuria (HP:0000103)2.09542194
57Congenital hepatic fibrosis (HP:0002612)2.09048117
58Postaxial foot polydactyly (HP:0001830)2.05673267
59Chronic otitis media (HP:0000389)2.05559162
60Vaginal atresia (HP:0000148)2.04365163
61Lissencephaly (HP:0001339)2.03794744
62Progressive cerebellar ataxia (HP:0002073)2.03655267
63Abnormal respiratory epithelium morphology (HP:0012253)2.03376451
64Abnormal respiratory motile cilium morphology (HP:0005938)2.03376451
65Aplasia/Hypoplasia of the spleen (HP:0010451)2.02141807
66Hepatic necrosis (HP:0002605)2.01703503
67Bile duct proliferation (HP:0001408)1.97582224
68Abnormal biliary tract physiology (HP:0012439)1.97582224
69Optic disc pallor (HP:0000543)1.97565147
70Optic nerve hypoplasia (HP:0000609)1.96799423
71Thyroid-stimulating hormone excess (HP:0002925)1.96514708
72Methylmalonic aciduria (HP:0012120)1.96304750
73Absent/shortened dynein arms (HP:0200106)1.96058047
74Dynein arm defect of respiratory motile cilia (HP:0012255)1.96058047
75Asplenia (HP:0001746)1.95680974
76Gaze-evoked nystagmus (HP:0000640)1.93749825
77Oligodactyly (hands) (HP:0001180)1.93158042
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91596562
79Furrowed tongue (HP:0000221)1.90936616
80Chronic sinusitis (HP:0011109)1.89662844
81Male pseudohermaphroditism (HP:0000037)1.88848255
82Cerebellar dysplasia (HP:0007033)1.87602329
83Renal Fanconi syndrome (HP:0001994)1.86640320
84Progressive inability to walk (HP:0002505)1.86530744
85Abnormality of B cell number (HP:0010975)1.85663992
86Abnormality of the pons (HP:0007361)1.85475068
87Retinal dysplasia (HP:0007973)1.84323515
88Decreased circulating renin level (HP:0003351)1.84316153
89Broad-based gait (HP:0002136)1.83759880
90Hyperglycinemia (HP:0002154)1.83534110
91Stomach cancer (HP:0012126)1.83155864
92Supernumerary spleens (HP:0009799)1.81567176
93Aplasia/hypoplasia of the uterus (HP:0008684)1.80460674
94Postaxial hand polydactyly (HP:0001162)1.79960970
95Short tibia (HP:0005736)1.79819601
96Chorioretinal atrophy (HP:0000533)1.79283155
97Increased serum lactate (HP:0002151)1.79204392
98Congenital sensorineural hearing impairment (HP:0008527)1.79048282
99Focal motor seizures (HP:0011153)1.78740044
100Glycosuria (HP:0003076)1.78076260

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.96612172
2TLK13.06796345
3WNK42.89502744
4MAP4K22.81371355
5ADRBK22.79709748
6WNK32.67035907
7PINK12.63802754
8ZAK2.57677103
9TAOK32.49854268
10GRK12.40922052
11NUAK12.35479451
12BMPR1B2.20664230
13MAPK132.06824173
14STK392.03936360
15ACVR1B1.92880293
16MAP3K41.71009840
17CASK1.68931560
18INSRR1.67836695
19CAMKK21.66215803
20TXK1.64348787
21TNIK1.59544554
22VRK11.46649816
23BCKDK1.41013497
24MUSK1.35478096
25PAK31.34749012
26DAPK21.33252207
27OXSR11.24698525
28MKNK21.21194110
29VRK21.19927771
30ADRBK11.07650076
31EIF2AK31.03991008
32MAP2K71.03209927
33TRIM281.01598654
34DYRK21.00586966
35EPHA40.99477855
36STK38L0.98047166
37PNCK0.96729078
38PLK20.94637220
39PRKCG0.91719132
40MARK10.91240490
41PRKCE0.85684533
42PLK30.80399001
43TIE10.75369721
44CSNK1G10.75170507
45CSNK1G20.74046806
46PTK2B0.71618441
47BRSK20.70858895
48PRKCQ0.70167387
49PHKG10.69551751
50PHKG20.69551751
51MAP3K130.69374367
52CSNK1G30.68630163
53NTRK30.66246488
54MAP3K90.66105891
55ERBB30.64877789
56IKBKB0.63838351
57TGFBR10.61905540
58STK30.61256911
59PKN10.60016994
60NME10.59597844
61RPS6KA50.59106696
62MAPK150.55870611
63NTRK20.55736650
64MKNK10.55582573
65MAPKAPK50.54744677
66PLK40.54423889
67CAMKK10.53654859
68PIK3CA0.53029772
69TEC0.52506001
70PRKCI0.52006430
71PRKACA0.51011502
72NLK0.49764231
73CAMK2A0.49480910
74MAPKAPK30.48914999
75GRK70.47201176
76BCR0.46882940
77PASK0.46644349
78CAMK10.44845713
79PLK10.43960174
80MST40.41807968
81KDR0.40928972
82CSNK1A1L0.40046990
83NEK20.39279666
84PRKCA0.38353870
85WEE10.38202430
86KIT0.37687449
87TNK20.37621578
88LIMK10.37220495
89FGFR20.36075475
90OBSCN0.35793964
91PRKAA20.35785472
92PIK3CG0.35265249
93CSNK1A10.34246957
94ATR0.33150683
95IRAK10.33102535
96MAP2K60.32317253
97STK160.32314791
98TAF10.32279064
99ITK0.31617218
100CCNB10.31127679

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.04916462
2Linoleic acid metabolism_Homo sapiens_hsa005912.73277715
3Oxidative phosphorylation_Homo sapiens_hsa001902.51930082
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.44141728
5Nitrogen metabolism_Homo sapiens_hsa009102.23665730
6Butanoate metabolism_Homo sapiens_hsa006502.18547778
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16237434
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10179974
9Nicotine addiction_Homo sapiens_hsa050332.04679453
10Caffeine metabolism_Homo sapiens_hsa002322.03287408
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01933157
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99670020
13Protein export_Homo sapiens_hsa030601.94378714
14Parkinsons disease_Homo sapiens_hsa050121.91347384
15Selenocompound metabolism_Homo sapiens_hsa004501.80977542
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80672632
17RNA polymerase_Homo sapiens_hsa030201.80139288
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.77973604
19Homologous recombination_Homo sapiens_hsa034401.76672971
20Basal transcription factors_Homo sapiens_hsa030221.70336735
21Ether lipid metabolism_Homo sapiens_hsa005651.67363356
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66013048
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60303332
24RNA degradation_Homo sapiens_hsa030181.52593239
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47885145
26Olfactory transduction_Homo sapiens_hsa047401.47538971
27Fanconi anemia pathway_Homo sapiens_hsa034601.47283439
28Tryptophan metabolism_Homo sapiens_hsa003801.46302725
29Propanoate metabolism_Homo sapiens_hsa006401.41778814
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.36321593
31One carbon pool by folate_Homo sapiens_hsa006701.35966881
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33181817
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30978480
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28809220
35Chemical carcinogenesis_Homo sapiens_hsa052041.28047850
36Huntingtons disease_Homo sapiens_hsa050161.28017857
37Retinol metabolism_Homo sapiens_hsa008301.26659919
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.25722510
39Cardiac muscle contraction_Homo sapiens_hsa042601.25691224
40Primary immunodeficiency_Homo sapiens_hsa053401.25649512
41Taste transduction_Homo sapiens_hsa047421.24914368
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24108667
43ABC transporters_Homo sapiens_hsa020101.20959096
44Proteasome_Homo sapiens_hsa030501.14613128
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14462843
46Morphine addiction_Homo sapiens_hsa050321.13787183
47Peroxisome_Homo sapiens_hsa041461.10014905
48Alzheimers disease_Homo sapiens_hsa050101.06301767
49Arachidonic acid metabolism_Homo sapiens_hsa005901.01816453
50Insulin secretion_Homo sapiens_hsa049111.00763268
51Collecting duct acid secretion_Homo sapiens_hsa049661.00412876
52Regulation of autophagy_Homo sapiens_hsa041400.99580484
53Ribosome_Homo sapiens_hsa030100.98448502
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97627497
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92251708
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87168669
57GABAergic synapse_Homo sapiens_hsa047270.86329765
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.80593609
59Circadian entrainment_Homo sapiens_hsa047130.79353746
60Fat digestion and absorption_Homo sapiens_hsa049750.79019490
61Purine metabolism_Homo sapiens_hsa002300.78304238
62Glutamatergic synapse_Homo sapiens_hsa047240.76384090
63Serotonergic synapse_Homo sapiens_hsa047260.76371358
64beta-Alanine metabolism_Homo sapiens_hsa004100.73375553
65Steroid biosynthesis_Homo sapiens_hsa001000.72606514
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72404182
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71643166
68Sulfur metabolism_Homo sapiens_hsa009200.69604656
69Ovarian steroidogenesis_Homo sapiens_hsa049130.68373030
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68049146
71Metabolic pathways_Homo sapiens_hsa011000.66038382
72Calcium signaling pathway_Homo sapiens_hsa040200.62834275
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61389706
74Glycerolipid metabolism_Homo sapiens_hsa005610.61332630
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58316688
76Pyrimidine metabolism_Homo sapiens_hsa002400.56590174
77Non-homologous end-joining_Homo sapiens_hsa034500.56193417
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.54978446
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54330700
80Salivary secretion_Homo sapiens_hsa049700.54040847
81Mineral absorption_Homo sapiens_hsa049780.53760236
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49339101
83Fatty acid degradation_Homo sapiens_hsa000710.47962018
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47103657
85Dopaminergic synapse_Homo sapiens_hsa047280.47080617
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45889910
87Dorso-ventral axis formation_Homo sapiens_hsa043200.43812290
88Amphetamine addiction_Homo sapiens_hsa050310.43299862
89Hedgehog signaling pathway_Homo sapiens_hsa043400.43151391
90Type I diabetes mellitus_Homo sapiens_hsa049400.42943367
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39306789
92Histidine metabolism_Homo sapiens_hsa003400.38029812
93Folate biosynthesis_Homo sapiens_hsa007900.37936123
94Vitamin digestion and absorption_Homo sapiens_hsa049770.37583118
95Sulfur relay system_Homo sapiens_hsa041220.34520728
96Basal cell carcinoma_Homo sapiens_hsa052170.33426518
97Fatty acid metabolism_Homo sapiens_hsa012120.30934797
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30495797
99Asthma_Homo sapiens_hsa053100.29903523
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.28706952

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