FAM92A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intraciliary transport (GO:0042073)3.42790901
2DNA double-strand break processing (GO:0000729)3.40492956
3nonmotile primary cilium assembly (GO:0035058)3.18127854
4chromatin remodeling at centromere (GO:0031055)3.17798095
5epithelial cilium movement (GO:0003351)3.16506368
6histone exchange (GO:0043486)3.09618175
7centriole replication (GO:0007099)3.07937781
8synapsis (GO:0007129)3.06831558
9response to pheromone (GO:0019236)3.02953573
10CENP-A containing nucleosome assembly (GO:0034080)2.98620231
11resolution of meiotic recombination intermediates (GO:0000712)2.91021523
12presynaptic membrane assembly (GO:0097105)2.85236190
13somite development (GO:0061053)2.83610876
14acrosome reaction (GO:0007340)2.82893211
15protein polyglutamylation (GO:0018095)2.81144102
16microtubule depolymerization (GO:0007019)2.80085256
17regulation of cilium movement (GO:0003352)2.72932877
18sperm motility (GO:0030317)2.71023608
19presynaptic membrane organization (GO:0097090)2.69470358
20cilium assembly (GO:0042384)2.69276027
21behavioral response to nicotine (GO:0035095)2.68611971
22cilium organization (GO:0044782)2.68306207
23cilium morphogenesis (GO:0060271)2.68297818
24cilium movement (GO:0003341)2.67156976
25limb bud formation (GO:0060174)2.67134841
26replication fork processing (GO:0031297)2.66072512
27axonemal dynein complex assembly (GO:0070286)2.64784987
28retinal ganglion cell axon guidance (GO:0031290)2.63318161
29regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.59796144
30neural tube formation (GO:0001841)2.58014466
31male meiosis (GO:0007140)2.55607566
32protein complex biogenesis (GO:0070271)2.53512678
33pyrimidine nucleobase catabolic process (GO:0006208)2.53470883
34spermatid development (GO:0007286)2.51600725
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.50973613
36mitochondrial respiratory chain complex I assembly (GO:0032981)2.46551311
37NADH dehydrogenase complex assembly (GO:0010257)2.46551311
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46551311
39chaperone-mediated protein transport (GO:0072321)2.44588519
40centriole assembly (GO:0098534)2.44550437
41regulation of centriole replication (GO:0046599)2.43158300
42mitochondrial respiratory chain complex assembly (GO:0033108)2.42510555
43positive regulation of mitochondrial fission (GO:0090141)2.40364324
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39964066
45microtubule polymerization or depolymerization (GO:0031109)2.37053301
46water-soluble vitamin biosynthetic process (GO:0042364)2.36333849
47cullin deneddylation (GO:0010388)2.36209003
48regulation of acyl-CoA biosynthetic process (GO:0050812)2.36073747
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.35457700
50smoothened signaling pathway (GO:0007224)2.32350680
51establishment of protein localization to mitochondrial membrane (GO:0090151)2.31237478
52appendage development (GO:0048736)2.29504227
53limb development (GO:0060173)2.29504227
54protein localization to cilium (GO:0061512)2.29294055
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.26013200
56cerebral cortex radially oriented cell migration (GO:0021799)2.25479986
57establishment of integrated proviral latency (GO:0075713)2.23492404
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.22767212
59neuron fate determination (GO:0048664)2.20679350
60kinetochore organization (GO:0051383)2.19971476
61DNA ligation (GO:0006266)2.19550289
62DNA replication-independent nucleosome assembly (GO:0006336)2.19252216
63DNA replication-independent nucleosome organization (GO:0034724)2.19252216
64regulation of meiosis I (GO:0060631)2.17016637
65postsynaptic membrane organization (GO:0001941)2.16595342
66regulation of cofactor metabolic process (GO:0051193)2.16527537
67regulation of coenzyme metabolic process (GO:0051196)2.16527537
68axonal fasciculation (GO:0007413)2.15462759
69male meiosis I (GO:0007141)2.15394951
70protein K6-linked ubiquitination (GO:0085020)2.15357304
71regulation of sulfur metabolic process (GO:0042762)2.13703078
72olfactory bulb development (GO:0021772)2.13551441
73reciprocal meiotic recombination (GO:0007131)2.13004396
74reciprocal DNA recombination (GO:0035825)2.13004396
75single strand break repair (GO:0000012)2.12972253
76protein-cofactor linkage (GO:0018065)2.12936073
77cellular component assembly involved in morphogenesis (GO:0010927)2.12932375
78chromosome organization involved in meiosis (GO:0070192)2.12529679
79piRNA metabolic process (GO:0034587)2.12466000
80DNA replication checkpoint (GO:0000076)2.11570525
81negative regulation of transcription regulatory region DNA binding (GO:2000678)2.10937755
82seminiferous tubule development (GO:0072520)2.10479780
83behavioral response to ethanol (GO:0048149)2.08411178
84recombinational repair (GO:0000725)2.07801012
85DNA damage response, detection of DNA damage (GO:0042769)2.07564496
86energy coupled proton transport, down electrochemical gradient (GO:0015985)2.07149208
87ATP synthesis coupled proton transport (GO:0015986)2.07149208
88cell proliferation in forebrain (GO:0021846)2.06562518
89binding of sperm to zona pellucida (GO:0007339)2.05700813
90double-strand break repair via homologous recombination (GO:0000724)2.05087401
91nucleobase catabolic process (GO:0046113)2.05017076
92DNA integration (GO:0015074)2.04090143
93protein deneddylation (GO:0000338)2.03987694
94otic vesicle formation (GO:0030916)2.03913541
95regulation of DNA endoreduplication (GO:0032875)2.02649280
96determination of left/right symmetry (GO:0007368)2.02302545
97regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.02236067
98proteasome assembly (GO:0043248)2.02108624
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.01924670
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.00765541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.57223279
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.33862053
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.83900090
4FUS_26573619_Chip-Seq_HEK293_Human2.82599713
5IGF1R_20145208_ChIP-Seq_DFB_Human2.67111074
6* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53158283
7ZNF274_21170338_ChIP-Seq_K562_Hela2.42125805
8VDR_22108803_ChIP-Seq_LS180_Human2.36688391
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34014735
10GBX2_23144817_ChIP-Seq_PC3_Human2.33862501
11EWS_26573619_Chip-Seq_HEK293_Human2.27496262
12TAF15_26573619_Chip-Seq_HEK293_Human2.24182356
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22566870
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.11566614
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07876189
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07341690
17* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01611163
18P300_19829295_ChIP-Seq_ESCs_Human2.00944462
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97339771
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95967508
21EZH2_22144423_ChIP-Seq_EOC_Human1.94393183
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91167959
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91123138
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85265259
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.82147553
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.79651199
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78003243
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65058103
29ELK1_19687146_ChIP-ChIP_HELA_Human1.63233650
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59476683
31RNF2_27304074_Chip-Seq_NSC_Mouse1.58981394
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58967313
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57255639
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56618982
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54257670
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.53447342
37MYC_18940864_ChIP-ChIP_HL60_Human1.45828166
38* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45287486
39* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44255188
40SMAD4_21799915_ChIP-Seq_A2780_Human1.43794796
41* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41656216
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40694479
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.39887122
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39821689
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39637055
46CBP_20019798_ChIP-Seq_JUKART_Human1.39637055
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38454306
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37630667
49* ER_23166858_ChIP-Seq_MCF-7_Human1.37363248
50* PIAS1_25552417_ChIP-Seq_VCAP_Human1.34724490
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31775730
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31650340
53IRF1_19129219_ChIP-ChIP_H3396_Human1.25782337
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25123282
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24626406
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24619392
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23962934
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23463128
59E2F7_22180533_ChIP-Seq_HELA_Human1.22920663
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22887995
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22887995
62* AR_25329375_ChIP-Seq_VCAP_Human1.22361197
63STAT3_23295773_ChIP-Seq_U87_Human1.21157476
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.19360945
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.18777889
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.18118253
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16657263
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.14865889
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12090328
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.10485114
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09982324
72RUNX2_22187159_ChIP-Seq_PCA_Human1.09795323
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09095280
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06538338
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05975192
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05245185
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03327386
78SOX9_26525672_Chip-Seq_HEART_Mouse1.03289856
79* TCF4_23295773_ChIP-Seq_U87_Human1.02793659
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.01960687
81* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01470335
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00329265
83* BCAT_22108803_ChIP-Seq_LS180_Human1.00135681
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97392979
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.97271963
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96449269
87* TCF4_22108803_ChIP-Seq_LS180_Human0.96438664
88SMAD4_21741376_ChIP-Seq_EPCs_Human0.96056781
89VDR_23849224_ChIP-Seq_CD4+_Human0.95868298
90TAL1_26923725_Chip-Seq_HPCs_Mouse0.95519748
91NANOG_19829295_ChIP-Seq_ESCs_Human0.95044731
92SOX2_19829295_ChIP-Seq_ESCs_Human0.95044731
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95009791
94JUN_21703547_ChIP-Seq_K562_Human0.94694138
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.94487134
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94018894
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92519646
98* TP53_22573176_ChIP-Seq_HFKS_Human0.90795030
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90542269
100P53_22387025_ChIP-Seq_ESCs_Mouse0.89207937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode2.87796775
2MP0003880_abnormal_central_pattern2.58019691
3MP0008789_abnormal_olfactory_epithelium2.15950860
4MP0001529_abnormal_vocalization2.13613505
5MP0010030_abnormal_orbit_morphology2.11893964
6MP0002102_abnormal_ear_morphology2.10947607
7MP0002234_abnormal_pharynx_morphology2.00968419
8MP0002938_white_spotting1.99527383
9MP0005499_abnormal_olfactory_system1.91419144
10MP0005394_taste/olfaction_phenotype1.91419144
11MP0001293_anophthalmia1.88665995
12MP0006072_abnormal_retinal_apoptosis1.87431217
13MP0003136_yellow_coat_color1.85113771
14MP0008877_abnormal_DNA_methylation1.81169485
15MP0000778_abnormal_nervous_system1.76934995
16MP0001984_abnormal_olfaction1.76276236
17MP0000049_abnormal_middle_ear1.73564814
18MP0003890_abnormal_embryonic-extraembry1.72845674
19MP0002233_abnormal_nose_morphology1.71801806
20MP0003937_abnormal_limbs/digits/tail_de1.65072623
21MP0005187_abnormal_penis_morphology1.56262763
22MP0003122_maternal_imprinting1.56109065
23MP0003121_genomic_imprinting1.54881489
24MP0008058_abnormal_DNA_repair1.53793851
25MP0000631_abnormal_neuroendocrine_gland1.50802793
26MP0009697_abnormal_copulation1.48603095
27MP0002160_abnormal_reproductive_system1.47801950
28MP0005253_abnormal_eye_physiology1.44888135
29MP0003119_abnormal_digestive_system1.40690402
30MP0005551_abnormal_eye_electrophysiolog1.36893652
31MP0004133_heterotaxia1.35424325
32MP0005248_abnormal_Harderian_gland1.34779413
33MP0006276_abnormal_autonomic_nervous1.30561251
34MP0002837_dystrophic_cardiac_calcinosis1.26553582
35MP0001188_hyperpigmentation1.26126666
36MP0005410_abnormal_fertilization1.25072197
37MP0003283_abnormal_digestive_organ1.23481448
38MP0003938_abnormal_ear_development1.22440686
39MP0002653_abnormal_ependyma_morphology1.21449044
40MP0003787_abnormal_imprinting1.21237635
41MP0001286_abnormal_eye_development1.21211624
42MP0009046_muscle_twitch1.20063159
43MP0003698_abnormal_male_reproductive1.19397801
44MP0001929_abnormal_gametogenesis1.18971930
45MP0002751_abnormal_autonomic_nervous1.17975519
46MP0003755_abnormal_palate_morphology1.16754024
47MP0002184_abnormal_innervation1.16318436
48MP0002210_abnormal_sex_determination1.15050367
49MP0005391_vision/eye_phenotype1.14999492
50MP0010094_abnormal_chromosome_stability1.14348629
51MP0005646_abnormal_pituitary_gland1.13012420
52MP0002638_abnormal_pupillary_reflex1.12593375
53MP0001486_abnormal_startle_reflex1.11644967
54MP0002282_abnormal_trachea_morphology1.11152561
55MP0001299_abnormal_eye_distance/1.09563817
56MP0001485_abnormal_pinna_reflex1.09554179
57MP0002697_abnormal_eye_size1.09161480
58MP0002272_abnormal_nervous_system1.08523237
59MP0004215_abnormal_myocardial_fiber1.06399436
60MP0009250_abnormal_appendicular_skeleto1.05672575
61MP0000566_synostosis1.05314337
62MP0000955_abnormal_spinal_cord1.05169937
63MP0003315_abnormal_perineum_morphology1.04615743
64MP0008057_abnormal_DNA_replication1.03932247
65MP0002752_abnormal_somatic_nervous1.03390624
66MP0008932_abnormal_embryonic_tissue1.00581019
67MP0002822_catalepsy1.00532696
68MP0003385_abnormal_body_wall1.00386926
69MP0000026_abnormal_inner_ear0.99251577
70MP0003861_abnormal_nervous_system0.98035242
71MP0003718_maternal_effect0.96307618
72MP0000653_abnormal_sex_gland0.95833475
73MP0003567_abnormal_fetal_cardiomyocyte0.95001774
74MP0001145_abnormal_male_reproductive0.94635459
75MP0005195_abnormal_posterior_eye0.94383540
76MP0009745_abnormal_behavioral_response0.94129620
77MP0004885_abnormal_endolymph0.92706840
78MP0003693_abnormal_embryo_hatching0.92589232
79MP0009379_abnormal_foot_pigmentation0.91900373
80MP0002557_abnormal_social/conspecific_i0.90979842
81MP0003935_abnormal_craniofacial_develop0.90931915
82MP0005084_abnormal_gallbladder_morpholo0.90906090
83MP0002736_abnormal_nociception_after0.89399166
84MP0004142_abnormal_muscle_tone0.88475294
85MP0003942_abnormal_urinary_system0.88259287
86MP0000427_abnormal_hair_cycle0.88185502
87MP0000569_abnormal_digit_pigmentation0.87710352
88MP0003123_paternal_imprinting0.87105311
89MP0009053_abnormal_anal_canal0.85182930
90MP0002734_abnormal_mechanical_nocicepti0.84527505
91MP0004270_analgesia0.84105626
92MP0002882_abnormal_neuron_morphology0.83177850
93MP0009780_abnormal_chondrocyte_physiolo0.82873973
94MP0005389_reproductive_system_phenotype0.82353747
95MP0002928_abnormal_bile_duct0.82192343
96MP0005423_abnormal_somatic_nervous0.81948039
97MP0003635_abnormal_synaptic_transmissio0.80972150
98MP0000647_abnormal_sebaceous_gland0.80786012
99MP0002092_abnormal_eye_morphology0.80493559
100MP0005379_endocrine/exocrine_gland_phen0.80396763

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)3.26064850
2True hermaphroditism (HP:0010459)3.24086775
3Medial flaring of the eyebrow (HP:0010747)3.16512978
4Gait imbalance (HP:0002141)3.01752972
5Congenital primary aphakia (HP:0007707)2.96262288
6Nephronophthisis (HP:0000090)2.92409941
7Pancreatic cysts (HP:0001737)2.86117188
8Chronic hepatic failure (HP:0100626)2.84212940
9Molar tooth sign on MRI (HP:0002419)2.82246180
10Abnormality of midbrain morphology (HP:0002418)2.82246180
11Genital tract atresia (HP:0001827)2.72896999
12Nephrogenic diabetes insipidus (HP:0009806)2.68912276
13Vaginal atresia (HP:0000148)2.61779645
14Anophthalmia (HP:0000528)2.48955950
15Aplasia/Hypoplasia of the tongue (HP:0010295)2.46490223
16Abnormality of the labia minora (HP:0012880)2.44787510
17Abnormality of the renal medulla (HP:0100957)2.40445466
18Type II lissencephaly (HP:0007260)2.40310063
19Oligodactyly (hands) (HP:0001180)2.35394322
20Sclerocornea (HP:0000647)2.32324216
21Short tibia (HP:0005736)2.30194964
22Occipital encephalocele (HP:0002085)2.29646510
23Intestinal atresia (HP:0011100)2.29279678
24Cerebellar dysplasia (HP:0007033)2.29161704
25Aplasia/Hypoplasia of the tibia (HP:0005772)2.26612122
26Volvulus (HP:0002580)2.25332950
27Postaxial foot polydactyly (HP:0001830)2.24734944
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.23860436
29Tubulointerstitial nephritis (HP:0001970)2.22653072
30Acute necrotizing encephalopathy (HP:0006965)2.21081480
31Abnormal respiratory motile cilium physiology (HP:0012261)2.20113517
32Colon cancer (HP:0003003)2.18786466
33Retinal dysplasia (HP:0007973)2.18081594
34Postaxial hand polydactyly (HP:0001162)2.17735009
35Poor coordination (HP:0002370)2.17585575
36Abnormal ciliary motility (HP:0012262)2.16357910
37Optic nerve hypoplasia (HP:0000609)2.11888969
38Supernumerary spleens (HP:0009799)2.11714405
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.10573168
40Male pseudohermaphroditism (HP:0000037)2.10297277
41Preaxial hand polydactyly (HP:0001177)2.09106776
42Anencephaly (HP:0002323)2.08065371
43Absent/shortened dynein arms (HP:0200106)2.07863582
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.07863582
45Meckel diverticulum (HP:0002245)2.04395672
46Rhinitis (HP:0012384)2.04318438
47Abnormality of the ileum (HP:0001549)2.03020600
48Progressive macrocephaly (HP:0004481)1.99194355
49Ectopic kidney (HP:0000086)1.97228153
50Increased hepatocellular lipid droplets (HP:0006565)1.96951006
51Acute encephalopathy (HP:0006846)1.94660251
52Triphalangeal thumb (HP:0001199)1.94022661
53Hyperglycinemia (HP:0002154)1.92354392
54Abnormal respiratory motile cilium morphology (HP:0005938)1.90426891
55Abnormal respiratory epithelium morphology (HP:0012253)1.90426891
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89889414
57Lipid accumulation in hepatocytes (HP:0006561)1.88989449
58Gastrointestinal atresia (HP:0002589)1.88870573
59Abnormality of chromosome stability (HP:0003220)1.87274641
60Adrenal hypoplasia (HP:0000835)1.86413989
61Abnormal lung lobation (HP:0002101)1.84759468
62Abnormal mitochondria in muscle tissue (HP:0008316)1.81111406
63Specific learning disability (HP:0001328)1.79902570
64Broad foot (HP:0001769)1.79860981
65Cystic liver disease (HP:0006706)1.79765200
66Mitochondrial inheritance (HP:0001427)1.76650541
67Median cleft lip (HP:0000161)1.76075317
68Oligodactyly (HP:0012165)1.73299761
69Astigmatism (HP:0000483)1.71245316
70Renal hypoplasia (HP:0000089)1.70237549
71Lissencephaly (HP:0001339)1.69181919
72Aganglionic megacolon (HP:0002251)1.68235073
73Drooling (HP:0002307)1.67942391
74Reticulocytopenia (HP:0001896)1.67531157
75Increased CSF lactate (HP:0002490)1.66676449
76Bifid tongue (HP:0010297)1.66604155
77Abnormality of the renal cortex (HP:0011035)1.66100083
78Decreased testicular size (HP:0008734)1.64530424
79Abnormality of the duodenum (HP:0002246)1.64135110
80Chromsome breakage (HP:0040012)1.61476869
81Bilateral microphthalmos (HP:0007633)1.61164107
82Abnormal sex determination (HP:0012244)1.61159056
83Sex reversal (HP:0012245)1.61159056
84Congenital hepatic fibrosis (HP:0002612)1.60755108
85Abnormality of the metopic suture (HP:0005556)1.60752820
86Dandy-Walker malformation (HP:0001305)1.60509052
87Abnormality of macular pigmentation (HP:0008002)1.60387560
88Septo-optic dysplasia (HP:0100842)1.60362176
89Micropenis (HP:0000054)1.60298186
90Aplasia/Hypoplasia of the lens (HP:0008063)1.60196713
91Methylmalonic acidemia (HP:0002912)1.59305599
92Hyperinsulinemic hypoglycemia (HP:0000825)1.59015574
93Preaxial foot polydactyly (HP:0001841)1.58919577
94Esophageal atresia (HP:0002032)1.58592022
95Small intestinal stenosis (HP:0012848)1.58371999
96Duodenal stenosis (HP:0100867)1.58371999
97Narrow forehead (HP:0000341)1.57371424
98Abnormal biliary tract physiology (HP:0012439)1.54336677
99Bile duct proliferation (HP:0001408)1.54336677
100Atonic seizures (HP:0010819)1.53727321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK12.83251489
2TNIK2.64680616
3BMPR1B2.63838194
4PNCK2.40257190
5WNK32.33226759
6MAP4K22.30442415
7PLK42.25077371
8TRIM282.19608940
9CASK2.11868176
10FRK2.00220430
11MAP3K41.98495579
12WEE11.91781539
13EPHA41.86174373
14STK38L1.83839172
15CDC71.80838919
16BCR1.70303633
17BUB11.70147645
18ERBB31.68725143
19PLK21.66606226
20PBK1.63210274
21MAP2K71.51574976
22INSRR1.51032316
23MARK11.50622678
24NUAK11.49965109
25MKNK21.49530464
26BRSK21.48282307
27DYRK31.48043361
28DYRK21.47057715
29ZAK1.43216017
30MKNK11.42751900
31NEK11.32912027
32STK161.32898046
33SRPK11.29374061
34MAPK131.29244420
35PLK31.26482964
36CSNK1G21.12366653
37VRK11.10577605
38EIF2AK31.08443611
39CSNK1G11.05214469
40CDK191.04964246
41CSNK1A1L1.04422671
42EPHB21.02517406
43CSNK1G31.00804778
44MINK11.00043755
45PLK10.99956019
46STK390.98570685
47PAK30.97591934
48NEK20.96687658
49WNK40.92911191
50BRSK10.87946146
51GRK10.87202105
52TTK0.87182934
53LATS10.86862020
54ACVR1B0.81212558
55VRK20.80918845
56OBSCN0.78054774
57BRD40.77430588
58PRKCG0.76752498
59ADRBK20.75344483
60CDK30.73837672
61FGFR20.73824403
62TGFBR10.73645355
63EIF2AK10.71157095
64CCNB10.70168159
65NTRK30.70035581
66STK30.69397766
67FGFR10.67854590
68PRKCE0.67478428
69CDK80.67312847
70MUSK0.65010056
71PASK0.63943162
72NTRK20.61499871
73TLK10.60468881
74ATM0.59947218
75NLK0.58281521
76OXSR10.58229655
77BCKDK0.57408851
78TIE10.53850419
79MAP2K40.52739192
80AKT30.52600770
81TSSK60.51941649
82RPS6KA50.51345489
83ATR0.51108150
84CAMKK20.50855376
85CHEK20.50543141
86RPS6KA40.48873278
87TAF10.48657793
88AURKB0.48342148
89LIMK10.48208056
90MARK30.47339669
91MAPK150.45799857
92UHMK10.45647607
93MYLK0.45098396
94CDK140.43495845
95DYRK1A0.43445647
96CSNK1E0.42502109
97ADRBK10.42151869
98CAMK2A0.40911543
99CAMK10.38689875
100PRKACB0.37231190

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85998698
2Protein export_Homo sapiens_hsa030602.82347769
3Oxidative phosphorylation_Homo sapiens_hsa001902.39330908
4Fanconi anemia pathway_Homo sapiens_hsa034602.20524153
5Parkinsons disease_Homo sapiens_hsa050122.15935198
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96229680
7RNA polymerase_Homo sapiens_hsa030201.95388941
8Non-homologous end-joining_Homo sapiens_hsa034501.94852897
9Ribosome_Homo sapiens_hsa030101.94805979
10Homologous recombination_Homo sapiens_hsa034401.94342095
11Mismatch repair_Homo sapiens_hsa034301.90024228
12Propanoate metabolism_Homo sapiens_hsa006401.87015044
13Basal transcription factors_Homo sapiens_hsa030221.86270380
14Butanoate metabolism_Homo sapiens_hsa006501.85719610
15Hedgehog signaling pathway_Homo sapiens_hsa043401.78721022
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75609203
17Huntingtons disease_Homo sapiens_hsa050161.71254384
18DNA replication_Homo sapiens_hsa030301.67982682
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66537483
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54672728
21Phototransduction_Homo sapiens_hsa047441.53289625
22RNA degradation_Homo sapiens_hsa030181.52045736
23Nicotine addiction_Homo sapiens_hsa050331.51512216
24Nucleotide excision repair_Homo sapiens_hsa034201.51412361
25RNA transport_Homo sapiens_hsa030131.47638694
26Basal cell carcinoma_Homo sapiens_hsa052171.46084632
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43550383
28Cardiac muscle contraction_Homo sapiens_hsa042601.37233425
29Alzheimers disease_Homo sapiens_hsa050101.32544850
30Olfactory transduction_Homo sapiens_hsa047401.24084631
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.19946306
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.16526525
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15959067
34Proteasome_Homo sapiens_hsa030501.12485538
35Purine metabolism_Homo sapiens_hsa002301.09162557
36Base excision repair_Homo sapiens_hsa034101.08476589
37Pyruvate metabolism_Homo sapiens_hsa006201.07996791
38Steroid biosynthesis_Homo sapiens_hsa001001.07748429
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04227572
40Spliceosome_Homo sapiens_hsa030401.01966992
41Folate biosynthesis_Homo sapiens_hsa007901.00135530
42Peroxisome_Homo sapiens_hsa041460.99482117
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99342874
44Cell cycle_Homo sapiens_hsa041100.98441906
45Pyrimidine metabolism_Homo sapiens_hsa002400.98096227
46Hippo signaling pathway_Homo sapiens_hsa043900.96440086
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96406042
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95697340
49Taste transduction_Homo sapiens_hsa047420.92270483
50One carbon pool by folate_Homo sapiens_hsa006700.92110075
51Oocyte meiosis_Homo sapiens_hsa041140.91177362
52Regulation of autophagy_Homo sapiens_hsa041400.90077178
53GABAergic synapse_Homo sapiens_hsa047270.88406866
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87706587
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85026565
56Fatty acid elongation_Homo sapiens_hsa000620.81901760
57TGF-beta signaling pathway_Homo sapiens_hsa043500.80462669
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79851509
59Selenocompound metabolism_Homo sapiens_hsa004500.79850898
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.79715792
61Wnt signaling pathway_Homo sapiens_hsa043100.78316222
62Tryptophan metabolism_Homo sapiens_hsa003800.77092680
63Nitrogen metabolism_Homo sapiens_hsa009100.74985482
64Morphine addiction_Homo sapiens_hsa050320.74401605
65Cocaine addiction_Homo sapiens_hsa050300.73779701
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73742560
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72168334
68Circadian rhythm_Homo sapiens_hsa047100.70826278
69Vitamin B6 metabolism_Homo sapiens_hsa007500.70476637
70mRNA surveillance pathway_Homo sapiens_hsa030150.68560852
71Metabolic pathways_Homo sapiens_hsa011000.68076580
72Circadian entrainment_Homo sapiens_hsa047130.67405546
73beta-Alanine metabolism_Homo sapiens_hsa004100.66480256
74Glutathione metabolism_Homo sapiens_hsa004800.66071745
75Fatty acid metabolism_Homo sapiens_hsa012120.63926622
76Glutamatergic synapse_Homo sapiens_hsa047240.63888893
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63800347
78Alcoholism_Homo sapiens_hsa050340.63426160
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63376387
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62033890
81Gap junction_Homo sapiens_hsa045400.60155469
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58461544
83Axon guidance_Homo sapiens_hsa043600.57736349
84Dopaminergic synapse_Homo sapiens_hsa047280.57402256
85Fatty acid degradation_Homo sapiens_hsa000710.57011826
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56476442
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56058872
88Insulin secretion_Homo sapiens_hsa049110.54965773
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51456921
90Serotonergic synapse_Homo sapiens_hsa047260.49867456
91Chemical carcinogenesis_Homo sapiens_hsa052040.49630002
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48935433
93Retinol metabolism_Homo sapiens_hsa008300.48597278
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44735465
95Melanogenesis_Homo sapiens_hsa049160.44699458
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44643212
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43805338
98Amphetamine addiction_Homo sapiens_hsa050310.43752401
99Caffeine metabolism_Homo sapiens_hsa002320.42891110
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.42675462

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