FAM86C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.82172862
2DNA strand elongation involved in DNA replication (GO:0006271)4.51568364
3DNA strand elongation (GO:0022616)4.42056353
4formation of translation preinitiation complex (GO:0001731)4.33498904
5telomere maintenance via semi-conservative replication (GO:0032201)4.24220543
6ribosome assembly (GO:0042255)4.22329771
7IMP biosynthetic process (GO:0006188)4.05501385
8proteasome assembly (GO:0043248)3.98443004
9DNA unwinding involved in DNA replication (GO:0006268)3.88814732
10nucleobase biosynthetic process (GO:0046112)3.88647379
11establishment of viral latency (GO:0019043)3.86115167
12purine nucleobase biosynthetic process (GO:0009113)3.85873867
13ribosomal large subunit biogenesis (GO:0042273)3.81356116
14telomere maintenance via recombination (GO:0000722)3.79556226
15CENP-A containing nucleosome assembly (GO:0034080)3.66110981
16mitotic metaphase plate congression (GO:0007080)3.65145879
17chromatin remodeling at centromere (GO:0031055)3.63527883
18tRNA aminoacylation for protein translation (GO:0006418)3.60573262
19regulation of translational fidelity (GO:0006450)3.59569294
20mitotic recombination (GO:0006312)3.58875084
21pseudouridine synthesis (GO:0001522)3.58464863
22mitochondrial RNA metabolic process (GO:0000959)3.57504880
23rRNA modification (GO:0000154)3.57115710
24ribosome biogenesis (GO:0042254)3.51821482
25amino acid activation (GO:0043038)3.51234170
26tRNA aminoacylation (GO:0043039)3.51234170
27IMP metabolic process (GO:0046040)3.48758207
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44713752
29non-recombinational repair (GO:0000726)3.44360678
30double-strand break repair via nonhomologous end joining (GO:0006303)3.44360678
31ribosomal small subunit assembly (GO:0000028)3.42555689
32DNA replication checkpoint (GO:0000076)3.41983030
33ribonucleoprotein complex biogenesis (GO:0022613)3.41303855
34DNA replication initiation (GO:0006270)3.36265595
35maturation of 5.8S rRNA (GO:0000460)3.35072509
36peptidyl-arginine omega-N-methylation (GO:0035247)3.26378737
37protein maturation by protein folding (GO:0022417)3.25816955
38L-serine metabolic process (GO:0006563)3.25774454
39peptidyl-histidine modification (GO:0018202)3.25525536
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24081179
41telomere maintenance via telomere lengthening (GO:0010833)3.23703152
42spliceosomal snRNP assembly (GO:0000387)3.23212846
43base-excision repair (GO:0006284)3.20251629
44folic acid-containing compound biosynthetic process (GO:0009396)3.20234412
45nucleotide-excision repair, DNA gap filling (GO:0006297)3.19346256
46transcription from mitochondrial promoter (GO:0006390)3.17612295
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.17191951
48negative regulation of ligase activity (GO:0051352)3.17191951
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16169317
50rRNA processing (GO:0006364)3.16119920
51metaphase plate congression (GO:0051310)3.15433534
52DNA double-strand break processing (GO:0000729)3.14260466
53regulation of mitochondrial translation (GO:0070129)3.13215484
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11123923
55DNA ligation (GO:0006266)3.09834118
56DNA replication-dependent nucleosome organization (GO:0034723)3.09466630
57DNA replication-dependent nucleosome assembly (GO:0006335)3.09466630
58viral mRNA export from host cell nucleus (GO:0046784)3.08513808
59pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04731211
60histone arginine methylation (GO:0034969)3.04520770
61DNA replication-independent nucleosome organization (GO:0034724)3.02789364
62DNA replication-independent nucleosome assembly (GO:0006336)3.02789364
63transcription-coupled nucleotide-excision repair (GO:0006283)3.01072905
64DNA catabolic process, exonucleolytic (GO:0000738)3.01016524
65tRNA methylation (GO:0030488)2.98790253
66ncRNA 3-end processing (GO:0043628)2.98081702
67rRNA metabolic process (GO:0016072)2.97545511
68ribosomal small subunit biogenesis (GO:0042274)2.96817240
69histone exchange (GO:0043486)2.96096789
70cellular component biogenesis (GO:0044085)2.93718940
71cullin deneddylation (GO:0010388)2.90938064
72rRNA methylation (GO:0031167)2.90838480
73protein deneddylation (GO:0000338)2.88710522
74regulation of cellular amino acid metabolic process (GO:0006521)2.88046841
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86490028
76regulation of double-strand break repair via homologous recombination (GO:0010569)2.84860648
77regulation of centriole replication (GO:0046599)2.82508860
78RNA-dependent DNA replication (GO:0006278)2.82163621
79tRNA metabolic process (GO:0006399)2.81370102
80protein targeting to mitochondrion (GO:0006626)2.80162002
81peptidyl-arginine N-methylation (GO:0035246)2.78065595
82peptidyl-arginine methylation (GO:0018216)2.78065595
83telomere organization (GO:0032200)2.77021729
84DNA strand renaturation (GO:0000733)2.76795252
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76642219
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76642219
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76642219
88nucleobase-containing small molecule interconversion (GO:0015949)2.76338995
89telomere maintenance (GO:0000723)2.75413601
90signal transduction involved in DNA damage checkpoint (GO:0072422)2.75021782
91signal transduction involved in DNA integrity checkpoint (GO:0072401)2.75021782
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74771419
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74667539
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74069282
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74069282
96ncRNA metabolic process (GO:0034660)2.73764464
97rRNA transcription (GO:0009303)2.73626360
98telomere maintenance via telomerase (GO:0007004)2.72609887
99proline biosynthetic process (GO:0006561)2.69884527
100G1/S transition of mitotic cell cycle (GO:0000082)2.69855643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.30954217
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.45462716
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.90296283
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77041399
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.49042052
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.16743478
7MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12855158
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.08291315
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.04985183
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.02440928
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.91773920
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.84377819
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83603646
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81152339
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80826424
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73714857
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48105009
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.44412964
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42098121
20DCP1A_22483619_ChIP-Seq_HELA_Human2.41314277
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31505791
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27938751
23XRN2_22483619_ChIP-Seq_HELA_Human2.27598131
24GABP_19822575_ChIP-Seq_HepG2_Human2.27121802
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25572986
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22973886
27FOXP3_21729870_ChIP-Seq_TREG_Human2.13362547
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12890181
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.04157407
30MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01844877
31ZFX_18555785_ChIP-Seq_MESCs_Mouse1.96872444
32VDR_23849224_ChIP-Seq_CD4+_Human1.95616353
33ZNF263_19887448_ChIP-Seq_K562_Human1.94680837
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.88243783
35TTF2_22483619_ChIP-Seq_HELA_Human1.87856092
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83991852
37ELK1_19687146_ChIP-ChIP_HELA_Human1.81569093
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78602283
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75052454
40AR_21909140_ChIP-Seq_LNCAP_Human1.72490180
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71078034
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70680562
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69880436
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69486654
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.68936505
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67222119
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66687435
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66469246
49KDM5A_27292631_Chip-Seq_BREAST_Human1.62807394
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60767208
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60003533
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57778177
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50150807
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49187776
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47089001
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46310574
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43196955
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42057404
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.40583060
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40470511
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38930631
62MYC_22102868_ChIP-Seq_BL_Human1.35951003
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35317548
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33388260
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31596480
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28279138
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25947307
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25226949
69TFEB_21752829_ChIP-Seq_HELA_Human1.17717213
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17138127
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16557378
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11394582
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07931865
74CIITA_25753668_ChIP-Seq_RAJI_Human1.06814812
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.05778203
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05558928
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05269705
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04827381
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03111198
80MYC_18940864_ChIP-ChIP_HL60_Human1.03073433
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02840029
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99436443
83TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96070114
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95718124
85CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94955952
86FOXP1_21924763_ChIP-Seq_HESCs_Human0.93898000
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93707941
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92965175
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92439615
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92096488
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90064658
92ELF5_23300383_ChIP-Seq_T47D_Human0.87296478
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86702596
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84569499
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.82420762
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81302766
97TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80118212
98TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80115319
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.79667280
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79182529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.40433612
2MP0003693_abnormal_embryo_hatching4.24810168
3MP0004957_abnormal_blastocyst_morpholog3.79563116
4MP0000372_irregular_coat_pigmentation3.75574838
5MP0008058_abnormal_DNA_repair3.70020431
6MP0003111_abnormal_nucleus_morphology3.67162700
7MP0009697_abnormal_copulation3.27229276
8MP0003806_abnormal_nucleotide_metabolis3.16631635
9MP0003077_abnormal_cell_cycle2.98538806
10MP0008057_abnormal_DNA_replication2.93437815
11MP0008932_abnormal_embryonic_tissue2.77498744
12MP0003718_maternal_effect2.55132593
13MP0005075_abnormal_melanosome_morpholog2.52535554
14MP0004233_abnormal_muscle_weight2.14794396
15MP0003186_abnormal_redox_activity2.12395248
16MP0010030_abnormal_orbit_morphology2.03771923
17MP0001730_embryonic_growth_arrest1.99518861
18MP0008007_abnormal_cellular_replicative1.98743541
19MP0010307_abnormal_tumor_latency1.97518292
20MP0003786_premature_aging1.90690654
21MP0005408_hypopigmentation1.74184151
22MP0000350_abnormal_cell_proliferation1.72369506
23MP0005501_abnormal_skin_physiology1.71572372
24MP0006035_abnormal_mitochondrial_morpho1.63581417
25MP0002396_abnormal_hematopoietic_system1.61201386
26MP0006292_abnormal_olfactory_placode1.60249577
27MP0001697_abnormal_embryo_size1.59253746
28MP0005380_embryogenesis_phenotype1.55741361
29MP0001672_abnormal_embryogenesis/_devel1.55741361
30MP0000358_abnormal_cell_content/1.53173644
31MP0002080_prenatal_lethality1.52349277
32MP0006036_abnormal_mitochondrial_physio1.50537156
33MP0002938_white_spotting1.50520706
34MP0005257_abnormal_intraocular_pressure1.49525874
35MP0001661_extended_life_span1.37837555
36MP0000313_abnormal_cell_death1.34118899
37MP0003984_embryonic_growth_retardation1.34031457
38MP0001293_anophthalmia1.31644155
39MP0003941_abnormal_skin_development1.29449920
40MP0002019_abnormal_tumor_incidence1.27038808
41MP0001873_stomach_inflammation1.26772874
42MP0002085_abnormal_embryonic_tissue1.26233303
43MP0002088_abnormal_embryonic_growth/wei1.25420804
44MP0001764_abnormal_homeostasis1.22327945
45MP0002877_abnormal_melanocyte_morpholog1.16698544
46MP0002254_reproductive_system_inflammat1.15606150
47MP0004808_abnormal_hematopoietic_stem1.12263573
48MP0004197_abnormal_fetal_growth/weight/1.12146466
49MP0002084_abnormal_developmental_patter1.11631690
50MP0005451_abnormal_body_composition1.10682877
51MP0008789_abnormal_olfactory_epithelium1.08045879
52MP0008877_abnormal_DNA_methylation1.03692062
53MP0002210_abnormal_sex_determination1.02644718
54MP0002086_abnormal_extraembryonic_tissu1.02296040
55MP0004782_abnormal_surfactant_physiolog1.00007288
56MP0001529_abnormal_vocalization0.99837344
57MP0001881_abnormal_mammary_gland0.98874933
58MP0003136_yellow_coat_color0.97895480
59MP0000490_abnormal_crypts_of0.94489274
60MP0003656_abnormal_erythrocyte_physiolo0.93320871
61MP0002796_impaired_skin_barrier0.93196289
62MP0001849_ear_inflammation0.91733186
63MP0009333_abnormal_splenocyte_physiolog0.88003416
64MP0004147_increased_porphyrin_level0.87635142
65MP0000015_abnormal_ear_pigmentation0.87004817
66MP0005384_cellular_phenotype0.86456390
67MP0010352_gastrointestinal_tract_polyps0.85198775
68MP0003567_abnormal_fetal_cardiomyocyte0.83385116
69MP0009672_abnormal_birth_weight0.81164918
70MP0000627_abnormal_mammary_gland0.80297928
71MP0005499_abnormal_olfactory_system0.79686088
72MP0005394_taste/olfaction_phenotype0.79686088
73MP0001145_abnormal_male_reproductive0.79573687
74MP0003119_abnormal_digestive_system0.78611538
75MP0001929_abnormal_gametogenesis0.76420668
76MP0003315_abnormal_perineum_morphology0.76368531
77MP0000653_abnormal_sex_gland0.74445619
78MP0002132_abnormal_respiratory_system0.74356209
79MP0005395_other_phenotype0.73032368
80MP0005621_abnormal_cell_physiology0.72223821
81MP0002090_abnormal_vision0.69528104
82MP0002111_abnormal_tail_morphology0.69221746
83MP0005171_absent_coat_pigmentation0.69066562
84MP0003890_abnormal_embryonic-extraembry0.68644115
85MP0001324_abnormal_eye_pigmentation0.68637900
86MP0003943_abnormal_hepatobiliary_system0.68058800
87MP0006072_abnormal_retinal_apoptosis0.66643755
88MP0000750_abnormal_muscle_regeneration0.66105503
89MP0003699_abnormal_female_reproductive0.65323034
90MP0002092_abnormal_eye_morphology0.65086549
91MP0008260_abnormal_autophagy0.64629756
92MP0001853_heart_inflammation0.63250961
93MP0001119_abnormal_female_reproductive0.60737368
94MP0001545_abnormal_hematopoietic_system0.60418335
95MP0005397_hematopoietic_system_phenotyp0.60418335
96MP0000678_abnormal_parathyroid_gland0.60339114
97MP0000371_diluted_coat_color0.60231742
98MP0008770_decreased_survivor_rate0.57106251
99MP0003936_abnormal_reproductive_system0.56862505
100MP0002234_abnormal_pharynx_morphology0.56742112

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)4.36821868
2Type I transferrin isoform profile (HP:0003642)3.49972583
3Chromsome breakage (HP:0040012)3.37335747
4Abnormal number of erythroid precursors (HP:0012131)3.28396655
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27362999
6Microvesicular hepatic steatosis (HP:0001414)3.19354688
7Multiple enchondromatosis (HP:0005701)3.19058839
8Abnormal protein glycosylation (HP:0012346)3.12977603
9Abnormal glycosylation (HP:0012345)3.12977603
10Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.12977603
11Abnormal protein N-linked glycosylation (HP:0012347)3.12977603
12Rough bone trabeculation (HP:0100670)3.12753401
13Abnormality of cells of the erythroid lineage (HP:0012130)3.11345879
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.08219664
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.08219664
16Hepatocellular necrosis (HP:0001404)2.98137347
17Poikiloderma (HP:0001029)2.85591888
18Colon cancer (HP:0003003)2.81429027
19Acute encephalopathy (HP:0006846)2.73954764
20Increased serum lactate (HP:0002151)2.71680199
21Entropion (HP:0000621)2.70789002
22Abnormal mitochondria in muscle tissue (HP:0008316)2.70349985
23Progressive muscle weakness (HP:0003323)2.66009266
24Increased CSF lactate (HP:0002490)2.59773847
25Abnormality of glycolysis (HP:0004366)2.55723870
26Abnormal trabecular bone morphology (HP:0100671)2.55471440
27Acute necrotizing encephalopathy (HP:0006965)2.55149546
28Abnormality of the preputium (HP:0100587)2.48284829
29Ependymoma (HP:0002888)2.48047271
30Progressive external ophthalmoplegia (HP:0000590)2.46522691
31Microglossia (HP:0000171)2.43875322
32Increased serum pyruvate (HP:0003542)2.42167266
33Hepatic necrosis (HP:0002605)2.39487062
34Meckel diverticulum (HP:0002245)2.36859343
35Capillary hemangiomas (HP:0005306)2.36085553
36Reticulocytopenia (HP:0001896)2.34062221
37Abnormal lung lobation (HP:0002101)2.31408820
38Mitochondrial inheritance (HP:0001427)2.27243465
39Abnormality of the umbilical cord (HP:0010881)2.24723594
40Abnormality of DNA repair (HP:0003254)2.24199404
41Squamous cell carcinoma (HP:0002860)2.22809113
42Abnormality of the ileum (HP:0001549)2.19806045
43Ragged-red muscle fibers (HP:0003200)2.19006746
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.17277736
45Hypoplastic pelvis (HP:0008839)2.14774513
46Myelodysplasia (HP:0002863)2.12456103
47Lipid accumulation in hepatocytes (HP:0006561)2.11736581
48Birth length less than 3rd percentile (HP:0003561)2.09131065
49Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08709413
50Abnormality of chromosome stability (HP:0003220)2.07223721
51Exercise intolerance (HP:0003546)2.05692128
52Selective tooth agenesis (HP:0001592)2.04984668
53Horseshoe kidney (HP:0000085)2.04692619
54Increased intramyocellular lipid droplets (HP:0012240)2.03414693
55Lactic acidosis (HP:0003128)2.03115481
56Increased hepatocellular lipid droplets (HP:0006565)2.01667904
57Testicular atrophy (HP:0000029)2.01064052
58Cerebral edema (HP:0002181)1.96985844
59Carpal bone hypoplasia (HP:0001498)1.96984735
60Abnormality of methionine metabolism (HP:0010901)1.96732466
61Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94519108
62Macrocytic anemia (HP:0001972)1.94431231
63Gonadal dysgenesis (HP:0000133)1.94322899
64Absent thumb (HP:0009777)1.94273262
65Muscle fiber atrophy (HP:0100295)1.93324650
66Proximal placement of thumb (HP:0009623)1.91184448
67Increased muscle lipid content (HP:0009058)1.90610443
68Thrombocytosis (HP:0001894)1.88229308
69Delayed CNS myelination (HP:0002188)1.86850817
70Small intestinal stenosis (HP:0012848)1.86275224
71Duodenal stenosis (HP:0100867)1.86275224
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85981554
73Pancytopenia (HP:0001876)1.85532468
74Abnormality of the carotid arteries (HP:0005344)1.85270581
75Type 2 muscle fiber atrophy (HP:0003554)1.82169035
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81843329
77Aplastic anemia (HP:0001915)1.80820988
78Deviation of the thumb (HP:0009603)1.80539406
79Opisthotonus (HP:0002179)1.80453105
80Abnormal gallbladder physiology (HP:0012438)1.79100561
81Cholecystitis (HP:0001082)1.79100561
82Abnormality of the anterior horn cell (HP:0006802)1.78784505
83Degeneration of anterior horn cells (HP:0002398)1.78784505
84Thoracic kyphosis (HP:0002942)1.77171127
85Central scotoma (HP:0000603)1.74537322
86Sparse eyelashes (HP:0000653)1.73591788
87Hypoplasia of the pons (HP:0012110)1.73394634
88Shoulder girdle muscle weakness (HP:0003547)1.71935150
89Hyperglycinuria (HP:0003108)1.71552116
90Dyschromatopsia (HP:0007641)1.71245040
91Trismus (HP:0000211)1.70998046
92Secondary amenorrhea (HP:0000869)1.70983807
93Facial hemangioma (HP:0000329)1.70972796
94Abnormalities of placenta or umbilical cord (HP:0001194)1.70965110
95Nonimmune hydrops fetalis (HP:0001790)1.69743245
96Nephroblastoma (Wilms tumor) (HP:0002667)1.69519940
97Cleft eyelid (HP:0000625)1.68180887
98Progressive macrocephaly (HP:0004481)1.66813305
99Bone marrow hypocellularity (HP:0005528)1.66790465
100Postnatal microcephaly (HP:0005484)1.66716038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.15617880
2NME23.98030452
3CDC73.54089069
4BUB13.07899064
5PBK2.83370219
6EIF2AK12.65761989
7TTK2.56274645
8SCYL22.39497533
9SMG12.30687434
10EIF2AK32.26068703
11NUAK12.19254209
12SRPK12.18764825
13MUSK2.02162402
14TRIM281.92146041
15TSSK61.89637692
16ZAK1.81860251
17PIM21.71313430
18TAF11.70710892
19NME11.69730922
20PLK31.69268830
21BCKDK1.68570641
22NEK11.68442364
23PLK41.65012757
24EPHA21.60241561
25PAK41.50110125
26VRK11.48305568
27MKNK11.47124503
28TESK21.46859871
29CDK71.42819912
30ATR1.41562615
31BRSK21.39560913
32PLK11.35914943
33RPS6KB21.26997215
34WEE11.25355597
35STK161.24262701
36BRSK11.24116742
37CHEK21.21102749
38DAPK11.20433156
39KDR1.20043615
40AURKB1.15784302
41TESK11.11627501
42MST41.08009312
43STK41.01664245
44NEK21.00691258
45AURKA1.00600944
46MAP3K80.99961616
47ERBB40.95781623
48IRAK30.95570305
49CHEK10.84916101
50EIF2AK20.84836334
51BRAF0.83121749
52MKNK20.82307021
53CDK80.80323514
54MST1R0.79979638
55CSNK1G30.78024698
56LATS10.77958459
57FLT30.74041399
58CSNK1A1L0.71952627
59ARAF0.71857264
60RPS6KA40.69779615
61CDK40.68826436
62ATM0.68442148
63CDK120.64682573
64CDK90.62626863
65CDK60.60177779
66LIMK10.60171000
67TAOK20.58284162
68CSNK2A20.58052507
69CSNK1G10.53865051
70AKT20.52199670
71PAK10.51984020
72CDK20.49908357
73DYRK30.49040950
74PRKD30.48423685
75ILK0.48331325
76CSNK2A10.48044077
77PAK20.46997870
78ABL20.46968109
79ALK0.46202208
80CSNK1G20.44172029
81BMPR1B0.42582808
82DAPK30.41052824
83LATS20.40430282
84CDK10.40057664
85PRKCI0.39400003
86MELK0.36715306
87CLK10.35402341
88MATK0.34637342
89MTOR0.31475148
90RAF10.31334214
91SIK30.31024741
92MET0.29308879
93MAP3K120.29107171
94SIK10.27854533
95STK100.27039538
96PIM10.25747808
97MAPKAPK30.25648856
98PDK20.25421029
99WNK30.24033559
100MAP2K30.23841971

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.27049157
2Proteasome_Homo sapiens_hsa030504.05004465
3Mismatch repair_Homo sapiens_hsa034303.60299729
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.31636584
5Base excision repair_Homo sapiens_hsa034103.11358869
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06730961
7Ribosome_Homo sapiens_hsa030102.68952486
8Nucleotide excision repair_Homo sapiens_hsa034202.62476859
9Non-homologous end-joining_Homo sapiens_hsa034502.56360397
10Homologous recombination_Homo sapiens_hsa034402.46746741
11RNA polymerase_Homo sapiens_hsa030202.45221933
12RNA transport_Homo sapiens_hsa030132.31853591
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26787679
14Spliceosome_Homo sapiens_hsa030402.22797442
15One carbon pool by folate_Homo sapiens_hsa006702.11326007
16Fanconi anemia pathway_Homo sapiens_hsa034602.10907133
17Pyrimidine metabolism_Homo sapiens_hsa002402.07118196
18Fatty acid elongation_Homo sapiens_hsa000622.04632760
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90080857
20Cell cycle_Homo sapiens_hsa041101.83641552
21Sulfur relay system_Homo sapiens_hsa041221.83521101
22Biosynthesis of amino acids_Homo sapiens_hsa012301.70604849
23Basal transcription factors_Homo sapiens_hsa030221.65161478
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.59714314
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53485114
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40111205
27Protein export_Homo sapiens_hsa030601.38260527
28Pentose phosphate pathway_Homo sapiens_hsa000301.37825711
29RNA degradation_Homo sapiens_hsa030181.36776679
30Carbon metabolism_Homo sapiens_hsa012001.33360247
31Selenocompound metabolism_Homo sapiens_hsa004501.32529262
32Glutathione metabolism_Homo sapiens_hsa004801.29870298
33Folate biosynthesis_Homo sapiens_hsa007901.25054536
34mRNA surveillance pathway_Homo sapiens_hsa030151.19621151
35Pyruvate metabolism_Homo sapiens_hsa006201.17966001
36Purine metabolism_Homo sapiens_hsa002301.16734303
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09980838
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09574414
39Steroid biosynthesis_Homo sapiens_hsa001001.09371866
40Parkinsons disease_Homo sapiens_hsa050121.08904370
41N-Glycan biosynthesis_Homo sapiens_hsa005101.05689795
42Oxidative phosphorylation_Homo sapiens_hsa001901.05255038
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98739257
44Huntingtons disease_Homo sapiens_hsa050160.94845236
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94223731
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93820189
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91604580
48Thyroid cancer_Homo sapiens_hsa052160.87730581
49Vitamin B6 metabolism_Homo sapiens_hsa007500.86155217
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85949012
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82599585
52Propanoate metabolism_Homo sapiens_hsa006400.81792956
53p53 signaling pathway_Homo sapiens_hsa041150.80405640
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75206420
55Fructose and mannose metabolism_Homo sapiens_hsa000510.71722911
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69024424
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69020834
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68365119
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66346681
60Metabolic pathways_Homo sapiens_hsa011000.64275094
61Fatty acid metabolism_Homo sapiens_hsa012120.62941721
62Epstein-Barr virus infection_Homo sapiens_hsa051690.58813974
63Regulation of autophagy_Homo sapiens_hsa041400.57667775
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57563103
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56024014
66Galactose metabolism_Homo sapiens_hsa000520.49010572
67Peroxisome_Homo sapiens_hsa041460.45820489
68Alzheimers disease_Homo sapiens_hsa050100.44934825
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42267728
70Oocyte meiosis_Homo sapiens_hsa041140.41696648
71Bladder cancer_Homo sapiens_hsa052190.40521615
72Lysine degradation_Homo sapiens_hsa003100.39546036
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.38304017
74Herpes simplex infection_Homo sapiens_hsa051680.38126195
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.35364093
76Arginine and proline metabolism_Homo sapiens_hsa003300.35252259
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29686680
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28961243
79HTLV-I infection_Homo sapiens_hsa051660.28555435
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27605749
81Tyrosine metabolism_Homo sapiens_hsa003500.26007737
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24342000
83Basal cell carcinoma_Homo sapiens_hsa052170.21264554
84Viral carcinogenesis_Homo sapiens_hsa052030.19417606
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17852547
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.16185605
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15318981
88Butanoate metabolism_Homo sapiens_hsa006500.14514328
89Small cell lung cancer_Homo sapiens_hsa052220.14115284
90TGF-beta signaling pathway_Homo sapiens_hsa043500.12948166
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.12530399
92Other glycan degradation_Homo sapiens_hsa005110.09806127
93beta-Alanine metabolism_Homo sapiens_hsa004100.09382731
94Wnt signaling pathway_Homo sapiens_hsa043100.09339605
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07942863
96Phenylalanine metabolism_Homo sapiens_hsa003600.07748555
97Melanoma_Homo sapiens_hsa052180.06828655
98Hippo signaling pathway_Homo sapiens_hsa043900.06776513
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.05816857
100Systemic lupus erythematosus_Homo sapiens_hsa053220.04924254

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