FAM86B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1inner mitochondrial membrane organization (GO:0007007)6.66611633
2protein complex biogenesis (GO:0070271)5.39311131
3positive regulation of glycoprotein biosynthetic process (GO:0010560)5.30467748
4respiratory chain complex IV assembly (GO:0008535)5.29706305
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.19467997
6mitochondrial respiratory chain complex I assembly (GO:0032981)5.19467997
7NADH dehydrogenase complex assembly (GO:0010257)5.19467997
8mitochondrial respiratory chain complex assembly (GO:0033108)5.09821970
9interferon-gamma production (GO:0032609)5.07342664
10proteasome assembly (GO:0043248)5.05417453
11positive regulation of T cell chemotaxis (GO:0010820)5.01438018
12regulation of T cell chemotaxis (GO:0010819)5.01438018
13cytochrome complex assembly (GO:0017004)5.00633614
14positive regulation of T cell cytokine production (GO:0002726)4.96355136
15iron-sulfur cluster assembly (GO:0016226)4.82821302
16metallo-sulfur cluster assembly (GO:0031163)4.82821302
17positive regulation of glycoprotein metabolic process (GO:1903020)4.62540577
18peptidyl-histidine modification (GO:0018202)4.52793558
19regulation of hexokinase activity (GO:1903299)4.46881097
20regulation of glucokinase activity (GO:0033131)4.46881097
21energy homeostasis (GO:0097009)4.39924860
22positive regulation of transforming growth factor beta production (GO:0071636)4.19023280
23aggressive behavior (GO:0002118)4.07920157
24positive regulation of actin filament depolymerization (GO:0030836)3.86048086
25lactate metabolic process (GO:0006089)3.78122246
26artery smooth muscle contraction (GO:0014824)3.71939133
27mannosylation (GO:0097502)3.64689458
28negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.60724696
29epithelial cilium movement (GO:0003351)3.58213508
30negative regulation of T cell mediated immunity (GO:0002710)3.40940287
31regulation of T cell cytokine production (GO:0002724)3.38966787
32protein neddylation (GO:0045116)3.35638379
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31375199
34poly(A)+ mRNA export from nucleus (GO:0016973)3.27114003
35platelet dense granule organization (GO:0060155)3.24470854
36misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.24062327
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.19006737
38activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.18917964
39regulation of mitochondrial translation (GO:0070129)3.15683130
40positive regulation of T-helper 1 type immune response (GO:0002827)3.12301521
41cellular ketone body metabolic process (GO:0046950)3.11532796
42magnesium ion transport (GO:0015693)3.10228333
43DNA double-strand break processing (GO:0000729)3.09904139
44phasic smooth muscle contraction (GO:0014821)3.08656557
45ubiquinone metabolic process (GO:0006743)3.08131194
46tonic smooth muscle contraction (GO:0014820)3.07912868
47fructose metabolic process (GO:0006000)3.01169629
48dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.01146582
49positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)3.00899759
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95302173
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94996923
52somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92851612
53somatic hypermutation of immunoglobulin genes (GO:0016446)2.92851612
54urate metabolic process (GO:0046415)2.92737133
55synapsis (GO:0007129)2.92406697
56sterol biosynthetic process (GO:0016126)2.91738747
57chaperone-mediated protein transport (GO:0072321)2.91384165
58vascular smooth muscle contraction (GO:0014829)2.86839338
59cholesterol biosynthetic process (GO:0006695)2.86838284
60DNA damage response, detection of DNA damage (GO:0042769)2.86259541
61negative regulation of interleukin-2 production (GO:0032703)2.83971816
62preassembly of GPI anchor in ER membrane (GO:0016254)2.78274121
63amino-acid betaine metabolic process (GO:0006577)2.76598141
64cilium movement (GO:0003341)2.73788137
65ketone body metabolic process (GO:1902224)2.73576171
66cullin deneddylation (GO:0010388)2.73571491
67GPI anchor biosynthetic process (GO:0006506)2.73272693
68DNA deamination (GO:0045006)2.73102393
69energy coupled proton transport, down electrochemical gradient (GO:0015985)2.68859915
70ATP synthesis coupled proton transport (GO:0015986)2.68859915
71water-soluble vitamin biosynthetic process (GO:0042364)2.68352214
72phosphorelay signal transduction system (GO:0000160)2.64821607
73isoprenoid biosynthetic process (GO:0008299)2.64335254
74GPI anchor metabolic process (GO:0006505)2.64120289
75carnitine metabolic process (GO:0009437)2.63855139
76behavioral response to nicotine (GO:0035095)2.61039409
77regulation of protein glycosylation (GO:0060049)2.61000588
78intracellular protein transmembrane import (GO:0044743)2.60144741
79negative regulation of Ras GTPase activity (GO:0034261)2.58334353
80GDP-mannose metabolic process (GO:0019673)2.57810509
81cilium morphogenesis (GO:0060271)2.57478618
82lymphocyte chemotaxis (GO:0048247)2.56995503
83DNA strand renaturation (GO:0000733)2.55917519
84male meiosis (GO:0007140)2.52411859
85positive regulation of alpha-beta T cell proliferation (GO:0046641)2.46116495
86termination of RNA polymerase III transcription (GO:0006386)2.45455747
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.45455747
88regulation of nuclear cell cycle DNA replication (GO:0033262)2.44902290
89kidney morphogenesis (GO:0060993)2.43658788
90regulation of lymphocyte chemotaxis (GO:1901623)2.43365436
91protein deneddylation (GO:0000338)2.42992529
92negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.42143151
93C-terminal protein amino acid modification (GO:0018410)2.40967759
94respiratory electron transport chain (GO:0022904)2.40671282
95dopamine transport (GO:0015872)2.40357842
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.40274827
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.40274827
98protein targeting to mitochondrion (GO:0006626)2.38930534
99DNA catabolic process, exonucleolytic (GO:0000738)2.38923239
100oxidative phosphorylation (GO:0006119)2.37999708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.01643985
2ZNF274_21170338_ChIP-Seq_K562_Hela4.31829313
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59063133
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.09409783
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00531290
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70422029
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.63212286
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.38841166
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.38090282
10FUS_26573619_Chip-Seq_HEK293_Human2.29996331
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21758891
12SRF_21415370_ChIP-Seq_HL-1_Mouse2.09397161
13* VDR_22108803_ChIP-Seq_LS180_Human2.07470874
14IGF1R_20145208_ChIP-Seq_DFB_Human2.06344989
15VDR_23849224_ChIP-Seq_CD4+_Human2.02143261
16ELK1_19687146_ChIP-ChIP_HELA_Human2.02108061
17RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98610729
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91491208
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84593122
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82912501
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81062111
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80816159
23FOXP3_21729870_ChIP-Seq_TREG_Human1.80204566
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80187030
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.78136411
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76684750
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70097527
28EWS_26573619_Chip-Seq_HEK293_Human1.68706415
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66510186
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64205431
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.63157121
32ER_23166858_ChIP-Seq_MCF-7_Human1.61822551
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58053138
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56931655
35MYC_18940864_ChIP-ChIP_HL60_Human1.56291862
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.53990545
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.49703419
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46823864
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46035959
40GABP_19822575_ChIP-Seq_HepG2_Human1.45321807
41P300_19829295_ChIP-Seq_ESCs_Human1.43237565
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41278230
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40586280
44GBX2_23144817_ChIP-Seq_PC3_Human1.36425688
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36374515
46TP53_22573176_ChIP-Seq_HFKS_Human1.34840556
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34356908
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33635667
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32920106
50DCP1A_22483619_ChIP-Seq_HELA_Human1.28807900
51RNF2_27304074_Chip-Seq_NSC_Mouse1.22100513
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21210967
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21161253
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20418715
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19434979
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18036884
57NANOG_19829295_ChIP-Seq_ESCs_Human1.15943496
58SOX2_19829295_ChIP-Seq_ESCs_Human1.15943496
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15704537
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15417128
61P53_22387025_ChIP-Seq_ESCs_Mouse1.14705271
62AR_20517297_ChIP-Seq_VCAP_Human1.14388434
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10799619
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10760568
65CBP_20019798_ChIP-Seq_JUKART_Human1.10760568
66NCOR_22424771_ChIP-Seq_293T_Human1.10422103
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10012452
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09912880
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09756120
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07648613
71EZH2_22144423_ChIP-Seq_EOC_Human1.06664308
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06448486
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05000152
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04448810
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.04262263
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04015520
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.03953463
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03736219
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03601095
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03174006
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01104675
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01011513
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.00806841
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00209544
85MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00169109
86HTT_18923047_ChIP-ChIP_STHdh_Human0.99985021
87P300_18555785_Chip-Seq_ESCs_Mouse0.98962819
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.98765539
89PHF8_20622853_ChIP-Seq_HELA_Human0.98299222
90NFYB_21822215_ChIP-Seq_K562_Human0.97480964
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97384827
92SMAD4_21799915_ChIP-Seq_A2780_Human0.97350576
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96729823
94REST_18959480_ChIP-ChIP_MESCs_Mouse0.95539205
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95305434
96THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95094280
97ZFX_18555785_Chip-Seq_ESCs_Mouse0.94358666
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94313185
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93685087
100STAT3_23295773_ChIP-Seq_U87_Human0.93108609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.18459978
2MP0002938_white_spotting4.49658996
3MP0003787_abnormal_imprinting3.35329628
4MP0006292_abnormal_olfactory_placode3.02255584
5MP0006054_spinal_hemorrhage2.76020296
6MP0002653_abnormal_ependyma_morphology2.72968598
7MP0008995_early_reproductive_senescence2.68638821
8MP0001984_abnormal_olfaction2.63724189
9MP0000647_abnormal_sebaceous_gland2.50789244
10MP0008877_abnormal_DNA_methylation2.35772021
11MP0001986_abnormal_taste_sensitivity2.21314564
12MP0003718_maternal_effect2.17292332
13MP0005174_abnormal_tail_pigmentation2.14778121
14MP0003121_genomic_imprinting2.09255796
15MP0005253_abnormal_eye_physiology2.04180169
16MP0005645_abnormal_hypothalamus_physiol1.99464842
17MP0005187_abnormal_penis_morphology1.97030800
18MP0001529_abnormal_vocalization1.90571852
19MP0003786_premature_aging1.87223727
20MP0002736_abnormal_nociception_after1.84865800
21MP0003122_maternal_imprinting1.83997134
22MP0008058_abnormal_DNA_repair1.80318236
23MP0008789_abnormal_olfactory_epithelium1.79631852
24MP0006072_abnormal_retinal_apoptosis1.76921715
25MP0005394_taste/olfaction_phenotype1.75145142
26MP0005499_abnormal_olfactory_system1.75145142
27MP0000566_synostosis1.73839316
28MP0003806_abnormal_nucleotide_metabolis1.68368831
29MP0000613_abnormal_salivary_gland1.60775697
30MP0006035_abnormal_mitochondrial_morpho1.58860187
31MP0004133_heterotaxia1.57129662
32MP0002751_abnormal_autonomic_nervous1.54944848
33MP0001968_abnormal_touch/_nociception1.54878117
34MP0005075_abnormal_melanosome_morpholog1.53885724
35MP0003315_abnormal_perineum_morphology1.53607719
36MP0002006_tumorigenesis1.50096056
37MP0003011_delayed_dark_adaptation1.48897583
38MP0004147_increased_porphyrin_level1.44619326
39MP0003123_paternal_imprinting1.37479448
40MP0010094_abnormal_chromosome_stability1.32982656
41MP0000013_abnormal_adipose_tissue1.29708343
42MP0002557_abnormal_social/conspecific_i1.28495021
43MP0005551_abnormal_eye_electrophysiolog1.23399524
44MP0002234_abnormal_pharynx_morphology1.23258187
45MP0000427_abnormal_hair_cycle1.21676555
46MP0006276_abnormal_autonomic_nervous1.21017774
47MP0001293_anophthalmia1.20759486
48MP0002102_abnormal_ear_morphology1.17128797
49MP0002254_reproductive_system_inflammat1.15743177
50MP0006036_abnormal_mitochondrial_physio1.11696091
51MP0005310_abnormal_salivary_gland1.10588796
52MP0005085_abnormal_gallbladder_physiolo1.05242115
53MP0004957_abnormal_blastocyst_morpholog1.02819921
54MP0004142_abnormal_muscle_tone1.01586943
55MP0008875_abnormal_xenobiotic_pharmacok1.00127399
56MP0008932_abnormal_embryonic_tissue0.99796965
57MP0003119_abnormal_digestive_system0.99584414
58MP0001764_abnormal_homeostasis0.99024989
59MP0003646_muscle_fatigue0.98862003
60MP0002909_abnormal_adrenal_gland0.95289650
61MP0002095_abnormal_skin_pigmentation0.95068930
62MP0009745_abnormal_behavioral_response0.94111956
63MP0005391_vision/eye_phenotype0.93395024
64MP0002163_abnormal_gland_morphology0.93097878
65MP0005395_other_phenotype0.91487481
66MP0001485_abnormal_pinna_reflex0.90850631
67MP0002090_abnormal_vision0.90534747
68MP0000358_abnormal_cell_content/0.88970580
69MP0002572_abnormal_emotion/affect_behav0.88774306
70MP0000372_irregular_coat_pigmentation0.88483409
71MP0000049_abnormal_middle_ear0.87094886
72MP0001501_abnormal_sleep_pattern0.85783740
73MP0002139_abnormal_hepatobiliary_system0.84569777
74MP0002277_abnormal_respiratory_mucosa0.83313343
75MP0008872_abnormal_physiological_respon0.81640011
76MP0001963_abnormal_hearing_physiology0.81213794
77MP0000778_abnormal_nervous_system0.80597193
78MP0004885_abnormal_endolymph0.79797313
79MP0003186_abnormal_redox_activity0.79558067
80MP0004134_abnormal_chest_morphology0.78611141
81MP0001661_extended_life_span0.77196105
82MP0000026_abnormal_inner_ear0.76709452
83MP0002272_abnormal_nervous_system0.76701221
84MP0003136_yellow_coat_color0.76507212
85MP0001929_abnormal_gametogenesis0.76382873
86MP0002233_abnormal_nose_morphology0.74989340
87MP0003698_abnormal_male_reproductive0.74367271
88MP0004215_abnormal_myocardial_fiber0.74075638
89MP0009046_muscle_twitch0.73237289
90MP0000653_abnormal_sex_gland0.71820606
91MP0000751_myopathy0.71766471
92MP0002160_abnormal_reproductive_system0.71715308
93MP0002638_abnormal_pupillary_reflex0.71394968
94MP0003755_abnormal_palate_morphology0.71074571
95MP0000631_abnormal_neuroendocrine_gland0.69778207
96MP0002067_abnormal_sensory_capabilities0.66403413
97MP0002734_abnormal_mechanical_nocicepti0.65697068
98MP0010329_abnormal_lipoprotein_level0.64153264
99MP0002210_abnormal_sex_determination0.62978598
100MP0001145_abnormal_male_reproductive0.61308233

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.29204635
2Hepatic necrosis (HP:0002605)4.06296359
3Microvesicular hepatic steatosis (HP:0001414)3.79309243
4Abnormality of the labia minora (HP:0012880)3.62090215
5Mitochondrial inheritance (HP:0001427)3.53957278
6Acute necrotizing encephalopathy (HP:0006965)3.42042561
7Type II lissencephaly (HP:0007260)3.35974509
8Retrobulbar optic neuritis (HP:0100654)3.34087056
9Optic neuritis (HP:0100653)3.34087056
10Amniotic constriction ring (HP:0009775)3.26637387
11Abnormality of placental membranes (HP:0011409)3.26637387
12Increased CSF lactate (HP:0002490)3.25405512
13Abnormal mitochondria in muscle tissue (HP:0008316)3.24441474
14Palpebral edema (HP:0100540)3.16191304
15Acute encephalopathy (HP:0006846)3.13294798
163-Methylglutaconic aciduria (HP:0003535)3.07800733
17Type I transferrin isoform profile (HP:0003642)3.06957775
18Progressive macrocephaly (HP:0004481)3.03342690
19Pancreatic cysts (HP:0001737)3.01289710
20Hypothermia (HP:0002045)2.91439364
21Abnormality of midbrain morphology (HP:0002418)2.89630341
22Molar tooth sign on MRI (HP:0002419)2.89630341
23Abnormality of the pons (HP:0007361)2.87672967
24Hypoplasia of the pons (HP:0012110)2.84127419
25True hermaphroditism (HP:0010459)2.75509005
26Hypoplastic ischia (HP:0003175)2.75428180
27Pancreatic fibrosis (HP:0100732)2.74607976
28Congenital stationary night blindness (HP:0007642)2.70713934
29Abnormal protein glycosylation (HP:0012346)2.70433080
30Abnormal glycosylation (HP:0012345)2.70433080
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.70433080
32Abnormal protein N-linked glycosylation (HP:0012347)2.70433080
33Cerebral hypomyelination (HP:0006808)2.68351099
34Disproportionate short-trunk short stature (HP:0003521)2.60392605
35Orchitis (HP:0100796)2.56912257
36Cerebellar dysplasia (HP:0007033)2.49100254
37Neuroendocrine neoplasm (HP:0100634)2.43943703
38Medial flaring of the eyebrow (HP:0010747)2.43921609
39Increased serum pyruvate (HP:0003542)2.43405865
40Fetal akinesia sequence (HP:0001989)2.42372841
41Nephronophthisis (HP:0000090)2.38773357
42Retinal dysplasia (HP:0007973)2.34229997
43CNS demyelination (HP:0007305)2.33668839
44Abnormality of the ischium (HP:0003174)2.31486024
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29368707
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29368707
47Cutaneous melanoma (HP:0012056)2.26364340
48Increased serum lactate (HP:0002151)2.25670115
49Patchy hypopigmentation of hair (HP:0011365)2.20207822
50Urethral obstruction (HP:0000796)2.20012114
51Keratoconjunctivitis (HP:0001096)2.18531560
52Occipital encephalocele (HP:0002085)2.14601962
53Neoplasm of the adrenal gland (HP:0100631)2.13902042
54Increased hepatocellular lipid droplets (HP:0006565)2.13834011
55Respiratory failure (HP:0002878)2.10817278
56Abnormality of the antihelix (HP:0009738)2.08951715
57Cerebral edema (HP:0002181)2.08106344
58Abnormality of glycolysis (HP:0004366)2.07857663
59Chronic hepatic failure (HP:0100626)2.06320941
60Intestinal atresia (HP:0011100)2.05385541
61Neoplasm of the oral cavity (HP:0100649)2.04680695
62Gait imbalance (HP:0002141)2.03380739
63Congenital primary aphakia (HP:0007707)1.99664299
64Cortical visual impairment (HP:0100704)1.97540201
65Pheochromocytoma (HP:0002666)1.97450075
66Sclerocornea (HP:0000647)1.96012251
67Neoplasm of the adrenal cortex (HP:0100641)1.95834453
68Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95058941
69Gaze-evoked nystagmus (HP:0000640)1.94325653
70Emotional lability (HP:0000712)1.94055729
71Type 2 muscle fiber atrophy (HP:0003554)1.93400535
72Abnormal respiratory epithelium morphology (HP:0012253)1.93374885
73Abnormal respiratory motile cilium morphology (HP:0005938)1.93374885
74Abnormality of lateral ventricle (HP:0030047)1.91998243
75Abnormal ciliary motility (HP:0012262)1.91802120
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.90596911
77Absent speech (HP:0001344)1.88560371
78Poor suck (HP:0002033)1.84765824
79Myositis (HP:0100614)1.84538755
80Lactic acidosis (HP:0003128)1.84477556
81Nephrogenic diabetes insipidus (HP:0009806)1.83715709
82Lissencephaly (HP:0001339)1.80991131
83Cystic liver disease (HP:0006706)1.80622970
84Tubulointerstitial nephritis (HP:0001970)1.80546348
85Keratoconjunctivitis sicca (HP:0001097)1.79598101
86Pendular nystagmus (HP:0012043)1.79001998
87Lipid accumulation in hepatocytes (HP:0006561)1.78031364
88Colon cancer (HP:0003003)1.77865745
89White forelock (HP:0002211)1.77004871
90Prolonged QT interval (HP:0001657)1.76651019
91Dry hair (HP:0011359)1.75412521
92Optic nerve hypoplasia (HP:0000609)1.75328659
93Keratitis (HP:0000491)1.74569380
94Abnormal auditory evoked potentials (HP:0006958)1.74467490
95Abnormality of abdominal situs (HP:0011620)1.71955098
96Abdominal situs inversus (HP:0003363)1.71955098
97Postaxial foot polydactyly (HP:0001830)1.71672162
98Horizontal nystagmus (HP:0000666)1.68163016
99Thyroiditis (HP:0100646)1.67970764
100Decreased central vision (HP:0007663)1.67491317

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK96.73389871
2CDK194.58954796
3SRPK13.04317507
4ZAK2.79574342
5FRK2.67725599
6MAP4K22.43044985
7NEK12.28011660
8VRK22.05625550
9WNK31.99765187
10GRK11.89669921
11MAP3K121.85671908
12MKNK21.75607272
13MKNK11.74320065
14CSNK1G21.73309210
15STK241.66668669
16TRIM281.63390037
17TSSK61.61751728
18WNK41.54257171
19RPS6KA41.51903089
20ADRBK21.45875336
21EPHA31.42075636
22CSNK1G31.39691910
23CASK1.37409989
24TLK11.37368668
25MAPK131.34907036
26CSNK1G11.30033416
27LIMK11.29973526
28PLK31.29039331
29PLK21.27540428
30PRKD31.23468667
31FGFR21.22054175
32OXSR11.18395098
33PTK2B1.15499792
34MAP2K71.14811296
35NME11.09659810
36UHMK11.05849859
37BRSK21.02512707
38STK38L1.00551929
39MAP3K41.00144383
40VRK10.99645237
41MST40.96022107
42TIE10.92734951
43BCKDK0.92171381
44PINK10.91296732
45NUAK10.90271816
46PLK10.88827318
47MARK10.86731253
48DYRK30.85601983
49BUB10.84911828
50CSNK1A1L0.83132376
51DYRK20.82395477
52BCR0.80512007
53ERBB30.78955823
54BMPR1B0.78162321
55PRKCE0.77634277
56PAK40.76280070
57EIF2AK30.74294934
58FER0.70976446
59NTRK20.70945185
60ILK0.67688759
61TAOK30.67486407
62PHKG10.66536217
63PHKG20.66536217
64TESK10.65172298
65OBSCN0.62727577
66ERBB20.62138513
67EIF2AK10.60807291
68CAMK2A0.59950590
69CAMKK20.59902878
70PLK40.59365548
71CHEK20.55546737
72PRKCG0.54154418
73CDK30.54086232
74CAMK2B0.48303542
75CDC70.48046851
76DYRK1B0.47205408
77ACVR1B0.46787408
78BRSK10.46205255
79TTK0.45805095
80INSRR0.45784536
81CAMK2D0.44462008
82DAPK10.43941042
83EPHB20.41653048
84ATR0.41369700
85PBK0.41078407
86RPS6KA50.39697839
87PKN10.39033322
88MYLK0.36495664
89CSNK2A10.36118966
90CAMK40.35466468
91CSNK1A10.35341905
92PASK0.34544352
93CSNK1D0.32857958
94ATM0.31891708
95AURKA0.31703703
96MAP2K40.31652512
97ROCK10.30588005
98CAMK10.29842426
99PTK60.29792558
100PIK3CG0.29494113

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.85578248
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.56000687
3Steroid biosynthesis_Homo sapiens_hsa001003.29266018
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.63872157
5Non-homologous end-joining_Homo sapiens_hsa034502.52284947
6Proteasome_Homo sapiens_hsa030502.49068223
7Protein export_Homo sapiens_hsa030602.48315356
8Oxidative phosphorylation_Homo sapiens_hsa001902.44221532
9RNA polymerase_Homo sapiens_hsa030202.34687566
10Butanoate metabolism_Homo sapiens_hsa006502.27398592
11Parkinsons disease_Homo sapiens_hsa050122.21288110
12Basal transcription factors_Homo sapiens_hsa030222.08358717
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07525028
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01161407
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93975339
16Homologous recombination_Homo sapiens_hsa034401.86116212
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74532317
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73396134
19Propanoate metabolism_Homo sapiens_hsa006401.62395372
20Huntingtons disease_Homo sapiens_hsa050161.55543819
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44700705
22Fatty acid metabolism_Homo sapiens_hsa012121.36362976
23Fructose and mannose metabolism_Homo sapiens_hsa000511.31064790
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31019270
25Mismatch repair_Homo sapiens_hsa034301.30301291
26Alzheimers disease_Homo sapiens_hsa050101.28039047
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23319621
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21064998
29Pyrimidine metabolism_Homo sapiens_hsa002401.20363164
30Nucleotide excision repair_Homo sapiens_hsa034201.19344240
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18353207
32Pyruvate metabolism_Homo sapiens_hsa006201.16800093
33Biosynthesis of amino acids_Homo sapiens_hsa012301.15685763
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.09743212
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08372216
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05427614
37Fatty acid elongation_Homo sapiens_hsa000621.05071203
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03139304
39Peroxisome_Homo sapiens_hsa041461.01479069
40Sulfur relay system_Homo sapiens_hsa041221.01133103
41Folate biosynthesis_Homo sapiens_hsa007901.00091129
42Linoleic acid metabolism_Homo sapiens_hsa005910.99555838
43DNA replication_Homo sapiens_hsa030300.98526777
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98354582
45RNA transport_Homo sapiens_hsa030130.95765861
46Spliceosome_Homo sapiens_hsa030400.94138692
47Fatty acid degradation_Homo sapiens_hsa000710.92182462
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91893322
49Metabolic pathways_Homo sapiens_hsa011000.91040522
50Purine metabolism_Homo sapiens_hsa002300.87332147
51Glutathione metabolism_Homo sapiens_hsa004800.87296586
52Nicotine addiction_Homo sapiens_hsa050330.86920848
53Nitrogen metabolism_Homo sapiens_hsa009100.86781341
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86618882
55Fanconi anemia pathway_Homo sapiens_hsa034600.86446152
56Phototransduction_Homo sapiens_hsa047440.85851804
57Carbon metabolism_Homo sapiens_hsa012000.85723410
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84647306
59Base excision repair_Homo sapiens_hsa034100.82568379
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79752962
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79610916
62Circadian rhythm_Homo sapiens_hsa047100.77291582
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75257156
64N-Glycan biosynthesis_Homo sapiens_hsa005100.73259542
65One carbon pool by folate_Homo sapiens_hsa006700.72411894
66GABAergic synapse_Homo sapiens_hsa047270.70653415
67Ribosome_Homo sapiens_hsa030100.70549302
68RNA degradation_Homo sapiens_hsa030180.69670146
69Cardiac muscle contraction_Homo sapiens_hsa042600.68473504
70Taste transduction_Homo sapiens_hsa047420.67892930
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67539746
72Tryptophan metabolism_Homo sapiens_hsa003800.66661511
73Arginine and proline metabolism_Homo sapiens_hsa003300.64639151
74Vitamin B6 metabolism_Homo sapiens_hsa007500.63834742
75Ether lipid metabolism_Homo sapiens_hsa005650.61846791
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60908740
77Fatty acid biosynthesis_Homo sapiens_hsa000610.59378697
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54871228
79Chemical carcinogenesis_Homo sapiens_hsa052040.52810193
80Caffeine metabolism_Homo sapiens_hsa002320.52361090
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51397140
82Fat digestion and absorption_Homo sapiens_hsa049750.49765845
83p53 signaling pathway_Homo sapiens_hsa041150.47419803
84Retinol metabolism_Homo sapiens_hsa008300.47263349
85Primary immunodeficiency_Homo sapiens_hsa053400.45723727
86Oocyte meiosis_Homo sapiens_hsa041140.43527985
87Selenocompound metabolism_Homo sapiens_hsa004500.42839211
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.41947531
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41937955
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41219155
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39473818
92beta-Alanine metabolism_Homo sapiens_hsa004100.39341217
93Morphine addiction_Homo sapiens_hsa050320.38924272
94Lysine degradation_Homo sapiens_hsa003100.37955379
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37790429
96Serotonergic synapse_Homo sapiens_hsa047260.37512009
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.34147573
98Arachidonic acid metabolism_Homo sapiens_hsa005900.33580500
99Pentose phosphate pathway_Homo sapiens_hsa000300.32057718
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.31585068

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