FAM83H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a cause of amelogenesis imperfecta type 3 (AI3). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.76729957
2proline metabolic process (GO:0006560)6.87613373
3embryonic process involved in female pregnancy (GO:0060136)6.37570049
4establishment of apical/basal cell polarity (GO:0035089)6.08641656
5transcription from mitochondrial promoter (GO:0006390)5.69002852
6regulation of integrin activation (GO:0033623)5.22464260
7hemidesmosome assembly (GO:0031581)5.22412350
8establishment or maintenance of monopolar cell polarity (GO:0061339)5.15759573
9establishment of monopolar cell polarity (GO:0061162)5.15759573
10sulfur amino acid catabolic process (GO:0000098)4.85805063
11positive regulation of protein homooligomerization (GO:0032464)4.63314672
12intestinal cholesterol absorption (GO:0030299)4.55447477
13regulation of protein homooligomerization (GO:0032462)4.45090807
14oxidative demethylation (GO:0070989)4.38974828
15negative regulation of fatty acid biosynthetic process (GO:0045717)4.38467734
16cell-substrate junction assembly (GO:0007044)4.35021248
17multicellular organismal water homeostasis (GO:0050891)4.30871806
18glutamine family amino acid biosynthetic process (GO:0009084)4.29735835
19replication fork processing (GO:0031297)4.28830257
20desmosome organization (GO:0002934)4.22450161
21embryonic placenta development (GO:0001892)4.17093950
22Golgi transport vesicle coating (GO:0048200)4.15949627
23COPI coating of Golgi vesicle (GO:0048205)4.15949627
24positive regulation of epidermal cell differentiation (GO:0045606)4.14308807
25planar cell polarity pathway involved in neural tube closure (GO:0090179)4.10332789
26hair cycle (GO:0042633)4.10278596
27molting cycle (GO:0042303)4.10278596
28trophectodermal cell differentiation (GO:0001829)4.07707798
29regulation of translational fidelity (GO:0006450)4.05558203
30positive regulation of keratinocyte differentiation (GO:0045618)4.02466905
31regulation of cholesterol homeostasis (GO:2000188)3.99709207
32positive regulation of Cdc42 GTPase activity (GO:0043089)3.97458119
33regulation of hippo signaling (GO:0035330)3.93461804
34epithelial cell differentiation involved in prostate gland development (GO:0060742)3.87733958
35atrioventricular valve morphogenesis (GO:0003181)3.87430800
36mitochondrial DNA metabolic process (GO:0032042)3.86786422
37intestinal epithelial cell development (GO:0060576)3.79742928
38embryonic camera-type eye development (GO:0031076)3.78932263
39regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.77650228
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.75598230
41apoptotic process involved in morphogenesis (GO:0060561)3.75425904
42gap junction assembly (GO:0016264)3.73465001
43regulation of cholesterol biosynthetic process (GO:0045540)3.71867870
44bundle of His cell to Purkinje myocyte communication (GO:0086069)3.71295559
45semaphorin-plexin signaling pathway (GO:0071526)3.69492496
46mitotic G1 DNA damage checkpoint (GO:0031571)3.65181984
47focal adhesion assembly (GO:0048041)3.64314482
48cell-substrate adherens junction assembly (GO:0007045)3.64314482
49dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.64221300
50negative regulation of keratinocyte proliferation (GO:0010839)3.63654169
51negative regulation of Ras GTPase activity (GO:0034261)3.63100049
52adherens junction assembly (GO:0034333)3.56606502
53cytoskeletal anchoring at plasma membrane (GO:0007016)3.49664616
54keratinization (GO:0031424)3.47382513
55positive regulation of epidermis development (GO:0045684)3.44565883
56regulation of posttranscriptional gene silencing (GO:0060147)3.42154102
57regulation of gene silencing by miRNA (GO:0060964)3.42154102
58regulation of gene silencing by RNA (GO:0060966)3.42154102
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.41974921
60water homeostasis (GO:0030104)3.39015876
61branching involved in salivary gland morphogenesis (GO:0060445)3.38645555
62anatomical structure regression (GO:0060033)3.38322906
63very-low-density lipoprotein particle assembly (GO:0034379)3.36029273
64negative regulation of cell fate specification (GO:0009996)3.35603073
65keratinocyte proliferation (GO:0043616)3.35521438
66mitotic G1/S transition checkpoint (GO:0044819)3.35209289
67anterior/posterior axis specification, embryo (GO:0008595)3.34758873
68negative regulation of cell size (GO:0045792)3.32963191
69maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.26212072
70intestinal absorption (GO:0050892)3.25223390
71cellular response to ATP (GO:0071318)3.23927346
72alkaloid metabolic process (GO:0009820)3.18735493
73DNA deamination (GO:0045006)3.18177585
74activation of Rac GTPase activity (GO:0032863)3.16754105
75convergent extension (GO:0060026)3.16429355
76hypotonic response (GO:0006971)3.14342221
77surfactant homeostasis (GO:0043129)3.13955044
78G1 DNA damage checkpoint (GO:0044783)3.13874445
79somatic hypermutation of immunoglobulin genes (GO:0016446)3.12778223
80somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12778223
81labyrinthine layer development (GO:0060711)3.11201483
82positive regulation of protein oligomerization (GO:0032461)3.10757049
83protein localization to endosome (GO:0036010)3.10327270
84regulation of endothelial cell chemotaxis (GO:2001026)3.10271739
85negative regulation of cell cycle arrest (GO:0071157)3.10054650
86face development (GO:0060324)3.07093267
87regulation of water loss via skin (GO:0033561)3.06769234
88negative regulation of protein oligomerization (GO:0032460)3.06092911
89morphogenesis of embryonic epithelium (GO:0016331)3.06017905
90glucose 6-phosphate metabolic process (GO:0051156)3.05070704
91regulation of glucose import in response to insulin stimulus (GO:2001273)3.03844460
92regulation of fatty acid beta-oxidation (GO:0031998)3.02470523
93regulation of podosome assembly (GO:0071801)3.01080806
94negative regulation of JAK-STAT cascade (GO:0046426)3.00831908
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00095127
96ear development (GO:0043583)2.99411769
97polarized epithelial cell differentiation (GO:0030859)2.98925602
98cell differentiation involved in embryonic placenta development (GO:0060706)2.98452786
99mRNA cleavage (GO:0006379)2.97988374
100response to food (GO:0032094)2.97384742
101glucose catabolic process (GO:0006007)2.94183578
102regulation of keratinocyte differentiation (GO:0045616)2.92344021
103protein retention in ER lumen (GO:0006621)2.92225944
104poly(A)+ mRNA export from nucleus (GO:0016973)2.92036046
105L-ascorbic acid metabolic process (GO:0019852)2.89255061
106regulation of protein oligomerization (GO:0032459)2.86472216
107columnar/cuboidal epithelial cell development (GO:0002066)2.86100095
108regulation of cardioblast differentiation (GO:0051890)2.85132110
109regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.84557274
110negative regulation of fatty acid metabolic process (GO:0045922)2.84206004
111peptidyl-tyrosine autophosphorylation (GO:0038083)2.83372508
112L-alpha-amino acid transmembrane transport (GO:1902475)2.83145674
113tight junction assembly (GO:0070830)2.82541755
114endothelial cell chemotaxis (GO:0035767)2.81224474
115regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80031663
116spliceosomal tri-snRNP complex assembly (GO:0000244)2.79254881
117nodal signaling pathway (GO:0038092)2.77816372
118formation of translation preinitiation complex (GO:0001731)2.77663151
119negative regulation of chondrocyte differentiation (GO:0032331)2.76677850
120cardiac right ventricle morphogenesis (GO:0003215)2.76519957
121asymmetric protein localization (GO:0008105)2.75632321
122DNA strand renaturation (GO:0000733)2.74716723
123urea cycle (GO:0000050)2.74687080
124Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.74646643
1254-hydroxyproline metabolic process (GO:0019471)2.74399913
126cell-cell junction maintenance (GO:0045217)2.73661865
127maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73149945
128branching involved in mammary gland duct morphogenesis (GO:0060444)2.72897575
129regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.69877151
130negative regulation of viral release from host cell (GO:1902187)2.67481604
131triglyceride homeostasis (GO:0070328)2.66993222
132acylglycerol homeostasis (GO:0055090)2.66993222
133positive regulation by host of viral transcription (GO:0043923)2.66925424
134bone morphogenesis (GO:0060349)2.66613915
135keratinocyte differentiation (GO:0030216)2.65883989
136establishment of skin barrier (GO:0061436)2.65780405
137embryonic eye morphogenesis (GO:0048048)2.65001279
138L-phenylalanine metabolic process (GO:0006558)2.64655014
139erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.64655014
140cell-cell junction assembly (GO:0007043)2.64485647
141negative regulation of fatty acid transport (GO:2000192)2.63973374
142regulation of sister chromatid cohesion (GO:0007063)2.63756818
143epithelial cell-cell adhesion (GO:0090136)2.63561901
144ectoderm development (GO:0007398)2.63345629
145biotin metabolic process (GO:0006768)2.62934286
146apoptotic process involved in development (GO:1902742)2.62598874
147regulation of cell proliferation involved in kidney development (GO:1901722)2.62330210
148dosage compensation (GO:0007549)2.62037610
149mammary gland epithelial cell differentiation (GO:0060644)2.61954367
150negative regulation of cartilage development (GO:0061037)2.59818552
151regulation of establishment of planar polarity (GO:0090175)2.59403266
152protein localization to microtubule (GO:0035372)2.59196966
153heme transport (GO:0015886)2.57775211
154interferon-gamma secretion (GO:0072643)2.57183188
155receptor catabolic process (GO:0032801)2.56798762
156chemical homeostasis within a tissue (GO:0048875)2.56555193
157pentose-phosphate shunt (GO:0006098)2.55959703
158cellular zinc ion homeostasis (GO:0006882)2.55405672
159regulation of RNA export from nucleus (GO:0046831)2.55365452
160negative regulation of cell fate commitment (GO:0010454)2.54613795
161keratinocyte development (GO:0003334)2.54440213
162maternal placenta development (GO:0001893)2.54340286
163establishment or maintenance of apical/basal cell polarity (GO:0035088)2.54202839
164establishment or maintenance of bipolar cell polarity (GO:0061245)2.54202839
165establishment of planar polarity (GO:0001736)2.54168404
166establishment of tissue polarity (GO:0007164)2.54168404
167epidermis development (GO:0008544)2.53838004
168regulation of early endosome to late endosome transport (GO:2000641)2.53075452
169regulation of epidermal cell differentiation (GO:0045604)2.51570154
170regulation of cholesterol metabolic process (GO:0090181)2.51175774
171amyloid precursor protein catabolic process (GO:0042987)2.50837039
172regulation of epidermis development (GO:0045682)2.50680265
173urea metabolic process (GO:0019627)2.50558660
174GDP-mannose metabolic process (GO:0019673)2.50425849

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.73126724
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.25213935
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.70653228
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.68725855
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.65126168
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.65126168
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.65126168
8ZNF263_19887448_ChIP-Seq_K562_Human2.60351173
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.59246432
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.49724283
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48979883
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.41356807
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.36274976
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10280358
15KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.07442584
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.04716356
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04712614
18RACK7_27058665_Chip-Seq_MCF-7_Human2.04480950
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.01908121
20* LXR_22292898_ChIP-Seq_THP-1_Human2.00491038
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.97973690
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.95527121
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89936702
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.89166044
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.86380403
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.85029697
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84717447
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.84308008
29TCF3_18692474_ChIP-Seq_MEFs_Mouse1.81332240
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79005745
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.77619994
32TCF3_18692474_ChIP-Seq_MESCs_Mouse1.77475688
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.74881792
34POU5F1_16518401_ChIP-PET_MESCs_Mouse1.74076977
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.71644130
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67769351
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.64304242
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59912319
39VDR_21846776_ChIP-Seq_THP-1_Human1.58964416
40CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.58581808
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57403263
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57314981
43E2F7_22180533_ChIP-Seq_HELA_Human1.57147847
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56520890
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56196739
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.52816916
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.51822655
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48796714
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48471823
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46941816
51* ATF3_27146783_Chip-Seq_COLON_Human1.45682764
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.44817843
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42239108
54* TCF7_22412390_ChIP-Seq_EML_Mouse1.41567348
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41192944
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38241514
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.38015231
58GATA6_25053715_ChIP-Seq_YYC3_Human1.36972636
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36918772
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36918772
61* SMC4_20622854_ChIP-Seq_HELA_Human1.36258013
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.35217894
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34324830
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34290787
65* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34258649
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33517162
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32230799
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.26601291
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26303631
70AR_21909140_ChIP-Seq_LNCAP_Human1.26111204
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22464523
72* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21875598
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.21064797
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20322287
75EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20108482
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.19767626
77* KLF5_25053715_ChIP-Seq_YYC3_Human1.19074666
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19004919
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18837057
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18514044
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.15369496
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15040202
83NANOG_18692474_ChIP-Seq_MESCs_Mouse1.14458592
84* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13675814
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12900430
86CHD1_26751641_Chip-Seq_LNCaP_Human1.12818922
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12791424
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12785929
89KDM2B_26808549_Chip-Seq_DND41_Human1.12349920
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11958297
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11917623
92GATA3_24758297_ChIP-Seq_MCF-7_Human1.11908264
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11856193
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11197766
95MYC_22102868_ChIP-Seq_BL_Human1.10893762
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.10479390
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10106773
98TP53_22127205_ChIP-Seq_IMR90_Human1.09879735
99* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09262409
100CREB1_26743006_Chip-Seq_LNCaP_Human1.08973655
101OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08529203
102* TP63_22573176_ChIP-Seq_HFKS_Human1.07835288
103POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07834422
104* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07445734
105MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07321195
106* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06978074
107SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06952098
108MYC_18555785_ChIP-Seq_MESCs_Mouse1.06934877
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06391948
110PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06131113
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05971833
112FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05666386
113* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03831862
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03025028
115CLOCK_20551151_ChIP-Seq_293T_Human1.02781753
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02728223
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02589330
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02518615
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01632349
120BCOR_27268052_Chip-Seq_Bcells_Human1.00910511
121RARA_24833708_ChIP-Seq_LIVER_Mouse1.00413692
122NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00354369
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98632247
124* RARB_24833708_ChIP-Seq_LIVER_Mouse0.98616275
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98089283
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97710115
127CTCF_27219007_Chip-Seq_Bcells_Human0.97133451
128PHF8_20622854_ChIP-Seq_HELA_Human0.96303129
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95774156
130P68_20966046_ChIP-Seq_HELA_Human0.94867239
131EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94763505
132* KDM2B_26808549_Chip-Seq_K562_Human0.94709624
133* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94651318
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94008550
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93573745
136TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93564684
137MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93183381
138NCOR1_26117541_ChIP-Seq_K562_Human0.91626489
139CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91529111
140* SOX2_20726797_ChIP-Seq_SW620_Human0.91226329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.84190684
2MP0002796_impaired_skin_barrier3.81665392
3MP0010234_abnormal_vibrissa_follicle3.68737749
4MP0000579_abnormal_nail_morphology3.61101780
5MP0003705_abnormal_hypodermis_morpholog3.29040260
6MP0005085_abnormal_gallbladder_physiolo2.98705132
7MP0010030_abnormal_orbit_morphology2.87062020
8MP0005360_urolithiasis2.80085670
9MP0003453_abnormal_keratinocyte_physiol2.73310118
10MP0004264_abnormal_extraembryonic_tissu2.73261666
11MP0005365_abnormal_bile_salt2.55844116
12MP0010352_gastrointestinal_tract_polyps2.53174370
13MP0008057_abnormal_DNA_replication2.49564477
14MP0005501_abnormal_skin_physiology2.45741053
15MP0009278_abnormal_bone_marrow2.44778037
16MP0002139_abnormal_hepatobiliary_system2.24713730
17MP0002060_abnormal_skin_morphology2.24354484
18MP0002009_preneoplasia2.14987661
19MP0005275_abnormal_skin_tensile2.07348955
20MP0005451_abnormal_body_composition1.94672370
21MP0005409_darkened_coat_color1.93364544
22MP0003283_abnormal_digestive_organ1.90006044
23MP0004381_abnormal_hair_follicle1.89391247
24MP0000467_abnormal_esophagus_morphology1.88449002
25MP0005076_abnormal_cell_differentiation1.88428628
26MP0000462_abnormal_digestive_system1.87112068
27MP0002098_abnormal_vibrissa_morphology1.84328949
28MP0003566_abnormal_cell_adhesion1.81926570
29MP0002254_reproductive_system_inflammat1.81231803
30MP0009053_abnormal_anal_canal1.80010248
31MP0005171_absent_coat_pigmentation1.74656856
32MP0000762_abnormal_tongue_morphology1.74088095
33MP0004782_abnormal_surfactant_physiolog1.74000994
34MP0000678_abnormal_parathyroid_gland1.70324198
35MP0001666_abnormal_nutrient_absorption1.66506367
36MP0004019_abnormal_vitamin_homeostasis1.66144740
37MP0003941_abnormal_skin_development1.61958550
38MP0004233_abnormal_muscle_weight1.61780666
39MP0003119_abnormal_digestive_system1.60735948
40MP0004858_abnormal_nervous_system1.53688498
41MP0003890_abnormal_embryonic-extraembry1.50257914
42MP0001216_abnormal_epidermal_layer1.48566132
43MP0001849_ear_inflammation1.46543285
44MP0003806_abnormal_nucleotide_metabolis1.40781002
45MP0002282_abnormal_trachea_morphology1.37340208
46MP0003252_abnormal_bile_duct1.36380279
47MP0009840_abnormal_foam_cell1.34573010
48MP0002249_abnormal_larynx_morphology1.33855441
49MP0010678_abnormal_skin_adnexa1.33154539
50MP0005023_abnormal_wound_healing1.31089821
51MP0002089_abnormal_postnatal_growth/wei1.30097391
52MP0002086_abnormal_extraembryonic_tissu1.26226024
53MP0010771_integument_phenotype1.23929100
54MP0009780_abnormal_chondrocyte_physiolo1.23791431
55MP0000537_abnormal_urethra_morphology1.21506844
56MP0003123_paternal_imprinting1.20079575
57MP0004197_abnormal_fetal_growth/weight/1.17968404
58MP0002111_abnormal_tail_morphology1.16776706
59MP0005257_abnormal_intraocular_pressure1.15840432
60MP0008875_abnormal_xenobiotic_pharmacok1.15750216
61MP0002084_abnormal_developmental_patter1.14088525
62MP0002653_abnormal_ependyma_morphology1.13200737
63MP0004133_heterotaxia1.12303336
64MP0000470_abnormal_stomach_morphology1.11865681
65MP0003315_abnormal_perineum_morphology1.11327674
66MP0000377_abnormal_hair_follicle1.11316584
67MP0002877_abnormal_melanocyte_morpholog1.09914838
68MP0008260_abnormal_autophagy1.09241853
69MP0004272_abnormal_basement_membrane1.05150636
70MP0001340_abnormal_eyelid_morphology1.04905505
71MP0000516_abnormal_urinary_system1.04694273
72MP0005367_renal/urinary_system_phenotyp1.04694273
73MP0003693_abnormal_embryo_hatching1.03289644
74MP0010329_abnormal_lipoprotein_level1.03102569
75MP0001545_abnormal_hematopoietic_system1.02304606
76MP0005397_hematopoietic_system_phenotyp1.02304606
77MP0004185_abnormal_adipocyte_glucose1.01309578
78MP0000383_abnormal_hair_follicle0.99400038
79MP0008995_early_reproductive_senescence0.99053923
80MP0005666_abnormal_adipose_tissue0.97748616
81MP0003045_fibrosis0.97720504
82MP0009931_abnormal_skin_appearance0.97644872
83MP0000477_abnormal_intestine_morphology0.96954732
84MP0000490_abnormal_crypts_of0.96598991
85MP0009672_abnormal_birth_weight0.95512187
86MP0001881_abnormal_mammary_gland0.95002365
87MP0000367_abnormal_coat/_hair0.94348831
88MP0004957_abnormal_blastocyst_morpholog0.93137366
89MP0002085_abnormal_embryonic_tissue0.92755565
90MP0001697_abnormal_embryo_size0.92669598
91MP0003191_abnormal_cellular_cholesterol0.90747660
92MP0001293_anophthalmia0.89331115
93MP0000609_abnormal_liver_physiology0.88267475
94MP0001873_stomach_inflammation0.87464045
95MP0005248_abnormal_Harderian_gland0.85531922
96MP0003755_abnormal_palate_morphology0.83997105
97MP0004947_skin_inflammation0.83904285
98MP0000647_abnormal_sebaceous_gland0.83018299
99MP0001348_abnormal_lacrimal_gland0.82778494
100MP0000003_abnormal_adipose_tissue0.81941811
101MP0005375_adipose_tissue_phenotype0.80634786
102MP0001672_abnormal_embryogenesis/_devel0.80569646
103MP0005380_embryogenesis_phenotype0.80569646
104MP0003115_abnormal_respiratory_system0.79724415
105MP0005332_abnormal_amino_acid0.79124563
106MP0002269_muscular_atrophy0.77765489
107MP0000371_diluted_coat_color0.75783888
108MP0003786_premature_aging0.74063646
109MP0001730_embryonic_growth_arrest0.73331995
110MP0000538_abnormal_urinary_bladder0.72849293
111MP0003942_abnormal_urinary_system0.72715974
112MP0003567_abnormal_fetal_cardiomyocyte0.72310000
113MP0000858_altered_metastatic_potential0.71898494
114MP0005058_abnormal_lysosome_morphology0.70797644
115MP0002234_abnormal_pharynx_morphology0.70790189
116MP0002697_abnormal_eye_size0.69615398
117MP0000627_abnormal_mammary_gland0.68908719
118MP0003935_abnormal_craniofacial_develop0.68815572
119MP0000432_abnormal_head_morphology0.68653258
120MP0002080_prenatal_lethality0.67808515
121MP0006072_abnormal_retinal_apoptosis0.67734309
122MP0001243_abnormal_dermal_layer0.64423460
123MP0005083_abnormal_biliary_tract0.64408709
124MP0002932_abnormal_joint_morphology0.63405240
125MP0001346_abnormal_lacrimal_gland0.63125744
126MP0000427_abnormal_hair_cycle0.62934315
127MP0003984_embryonic_growth_retardation0.62930231
128MP0009379_abnormal_foot_pigmentation0.62831761
129MP0002088_abnormal_embryonic_growth/wei0.62125780
130MP0001664_abnormal_digestion0.58158667
131MP0002896_abnormal_bone_mineralization0.57948617
132MP0000350_abnormal_cell_proliferation0.55950062
133MP0010630_abnormal_cardiac_muscle0.55728858
134MP0005377_hearing/vestibular/ear_phenot0.55440971
135MP0003878_abnormal_ear_physiology0.55440971

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)5.88053602
2Hypotrichosis (HP:0001006)4.75215361
3Milia (HP:0001056)4.27406296
4Turricephaly (HP:0000262)4.19991648
5Pustule (HP:0200039)4.12775065
6Plantar hyperkeratosis (HP:0007556)4.08163749
7Right ventricular cardiomyopathy (HP:0011663)3.96139774
8Ulnar bowing (HP:0003031)3.74883116
9Concave nail (HP:0001598)3.72170813
10Pili torti (HP:0003777)3.67608856
11Septate vagina (HP:0001153)3.56596452
12Nail dystrophy (HP:0008404)3.56150834
13Rib fusion (HP:0000902)3.54907313
14Palmoplantar hyperkeratosis (HP:0000972)3.53327879
15Coronal craniosynostosis (HP:0004440)3.39503037
16Woolly hair (HP:0002224)3.38976445
17Abnormal hemoglobin (HP:0011902)3.36822789
18Onycholysis (HP:0001806)3.36803838
19Palmar hyperkeratosis (HP:0010765)3.35201561
20Hyperacusis (HP:0010780)3.32242180
21Fragile nails (HP:0001808)3.27882218
22Advanced eruption of teeth (HP:0006288)3.26620102
23Broad face (HP:0000283)3.19673626
24Flat acetabular roof (HP:0003180)3.13336196
25Ridged nail (HP:0001807)3.13080120
26Short humerus (HP:0005792)3.12006324
27Facial hemangioma (HP:0000329)2.98876939
28Hypochromic microcytic anemia (HP:0004840)2.98306415
29Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.94825742
30Vertebral hypoplasia (HP:0008417)2.94825742
31Malnutrition (HP:0004395)2.94735957
32Lip pit (HP:0100267)2.88563696
33Annular pancreas (HP:0001734)2.87632683
34Aplasia/hypoplasia of the humerus (HP:0006507)2.86613005
35Atrophic scars (HP:0001075)2.85083504
36Intrahepatic cholestasis (HP:0001406)2.83502459
37Hypobetalipoproteinemia (HP:0003563)2.83411266
38Poikiloderma (HP:0001029)2.80558419
39Distal lower limb muscle weakness (HP:0009053)2.79484525
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.77111279
41Vaginal fistula (HP:0004320)2.72509023
42Natal tooth (HP:0000695)2.70902083
43Male infertility (HP:0003251)2.69271808
44Rectovaginal fistula (HP:0000143)2.65820045
45Rectal fistula (HP:0100590)2.65820045
46Abnormality of the distal phalanges of the toes (HP:0010182)2.64817691
47Sparse eyelashes (HP:0000653)2.64240987
48Hypoplasia of dental enamel (HP:0006297)2.63857941
49Abnormality of the salivary glands (HP:0010286)2.63034598
50Cerebral aneurysm (HP:0004944)2.61738339
51Mucopolysacchariduria (HP:0008155)2.61226413
52Urinary glycosaminoglycan excretion (HP:0003541)2.61226413
53Short nail (HP:0001799)2.50872246
54Squamous cell carcinoma (HP:0002860)2.45260624
55Ankyloglossia (HP:0010296)2.43219232
56Intestinal fistula (HP:0100819)2.41600851
57Tongue fasciculations (HP:0001308)2.40172610
58Asymmetry of the thorax (HP:0001555)2.40106062
59Trismus (HP:0000211)2.37041963
60Thin bony cortex (HP:0002753)2.36693777
61Distal lower limb amyotrophy (HP:0008944)2.36542347
62Bowing of the arm (HP:0006488)2.36062831
63Bowed forearm bones (HP:0003956)2.36062831
64Abnormal hair laboratory examination (HP:0003328)2.35952312
65J-shaped sella turcica (HP:0002680)2.34201897
66Muscle fibrillation (HP:0010546)2.32659761
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.32547587
68Abnormality of polysaccharide metabolism (HP:0011012)2.32547587
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.32547587
70Increased IgM level (HP:0003496)2.32402053
71Selective tooth agenesis (HP:0001592)2.29794170
72Curly hair (HP:0002212)2.28662051
73Abnormality of the aortic arch (HP:0012303)2.26811470
74Sparse lateral eyebrow (HP:0005338)2.26191365
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26164029
76Aplasia cutis congenita (HP:0001057)2.25679438
77Micronodular cirrhosis (HP:0001413)2.21405184
78Xanthomatosis (HP:0000991)2.20773804
79Abnormal blistering of the skin (HP:0008066)2.20457775
80Hamartoma (HP:0010566)2.20367394
81Congenital hip dislocation (HP:0001374)2.20276259
82Acanthosis nigricans (HP:0000956)2.17685586
83Alacrima (HP:0000522)2.17175063
84Congenital ichthyosiform erythroderma (HP:0007431)2.16835245
85Choanal stenosis (HP:0000452)2.16778211
86Deviation of the thumb (HP:0009603)2.16535719
87Polycythemia (HP:0001901)2.15320466
88Orthostatic hypotension (HP:0001278)2.14188885
89Upper limb amyotrophy (HP:0009129)2.13312790
90Distal upper limb amyotrophy (HP:0007149)2.13312790
91Pancreatic islet-cell hyperplasia (HP:0004510)2.11066082
92Myocardial infarction (HP:0001658)2.10378083
93Abnormality of nail color (HP:0100643)2.10326305
94Premature skin wrinkling (HP:0100678)2.09698891
95Popliteal pterygium (HP:0009756)2.07266748
96Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05544653
97Absent radius (HP:0003974)2.04612449
98Cervical subluxation (HP:0003308)2.04371108
99Abnormality of the gastric mucosa (HP:0004295)2.04204792
100Sparse scalp hair (HP:0002209)2.03604118
101Germ cell neoplasia (HP:0100728)2.02639084
102Growth hormone excess (HP:0000845)2.01766100
103Nasolacrimal duct obstruction (HP:0000579)2.01455228
104Abnormality of oral frenula (HP:0000190)2.01229681
105Abnormality of aromatic amino acid family metabolism (HP:0004338)2.01091299
106Bronchomalacia (HP:0002780)1.99933730
107Long palpebral fissure (HP:0000637)1.99898209
108Abdominal distention (HP:0003270)1.99707825
109Hypolipoproteinemia (HP:0010981)1.98915131
110Dysostosis multiplex (HP:0000943)1.98056775
111Basal cell carcinoma (HP:0002671)1.95998898
112Gastrointestinal dysmotility (HP:0002579)1.95252684
113Abnormality of the dental root (HP:0006486)1.94400867
114Taurodontia (HP:0000679)1.94400867
115Abnormality of permanent molar morphology (HP:0011071)1.94400867
116Gastrointestinal atresia (HP:0002589)1.93937944
117Esophageal atresia (HP:0002032)1.93764834
118Dysautonomia (HP:0002459)1.93269139
119Vertebral fusion (HP:0002948)1.92927981
120Diaphragmatic weakness (HP:0009113)1.92886822
121Mildly elevated creatine phosphokinase (HP:0008180)1.91258540
122Absent forearm bone (HP:0003953)1.91106721
123Aplasia involving forearm bones (HP:0009822)1.91106721
124Abnormality of the distal phalanx of the thumb (HP:0009617)1.90442500
125Proximal placement of thumb (HP:0009623)1.89557546
126Achilles tendon contracture (HP:0001771)1.88826840
127Large for gestational age (HP:0001520)1.87321987
128Fragile skin (HP:0001030)1.86500285
129Anonychia (HP:0001798)1.85934031
130Pterygium (HP:0001059)1.85227853
131Intestinal atresia (HP:0011100)1.84969095
132Oligodontia (HP:0000677)1.84191284
133Anteriorly placed anus (HP:0001545)1.84142397
134Focal segmental glomerulosclerosis (HP:0000097)1.84026847
135Absent eyelashes (HP:0000561)1.83616500
136Fat malabsorption (HP:0002630)1.83507520
137Spinal cord compression (HP:0002176)1.82684002
138Deep venous thrombosis (HP:0002625)1.79647336
139Short chin (HP:0000331)1.78394138
140Breast hypoplasia (HP:0003187)1.78343925
141Abnormality of the Achilles tendon (HP:0005109)1.77493633
142Thick nail (HP:0001805)1.76675243
143Increased mean platelet volume (HP:0011877)1.75883387
144Ileus (HP:0002595)1.75740646
145Aplasia of the musculature (HP:0100854)1.75585912
146Hemorrhage of the eye (HP:0011885)1.75182209
147Axonal loss (HP:0003447)1.74944764
148Cheilitis (HP:0100825)1.74437914
149Urethral obstruction (HP:0000796)1.74192083
150Hyperparathyroidism (HP:0000843)1.74096687
151Bilateral sensorineural hearing impairment (HP:0008619)1.73907297
152Abnormality of molar morphology (HP:0011070)1.73496594
153Abnormality of molar (HP:0011077)1.73496594
154Neonatal death (HP:0003811)1.72281458
155Abnormality of the lacrimal duct (HP:0011481)1.71624422
156Abnormality of endocrine pancreas physiology (HP:0012093)1.71465199
157Abnormality of the pancreatic islet cells (HP:0006476)1.71465199
158Coarse hair (HP:0002208)1.69605421
159Increased connective tissue (HP:0009025)1.69535675
160Easy fatigability (HP:0003388)1.68776185
161Stridor (HP:0010307)1.67703799
162Progressive sensorineural hearing impairment (HP:0000408)1.66652536
163Progressive hearing impairment (HP:0001730)1.66484304
164Abnormality of the dental pulp (HP:0006479)1.66031593
165Aplasia involving bones of the extremities (HP:0009825)1.66026207
166Aplasia involving bones of the upper limbs (HP:0009823)1.66026207
167Aplasia of the phalanges of the hand (HP:0009802)1.66026207
168Glomerulosclerosis (HP:0000096)1.65434736
169Ureteral stenosis (HP:0000071)1.64824297
170Obstructive sleep apnea (HP:0002870)1.61800068
171Back pain (HP:0003418)1.61180226
172Reticulocytosis (HP:0001923)1.61077729
173Ventricular tachycardia (HP:0004756)1.61042093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.06785347
2DDR24.54651929
3MAPK154.54331974
4EPHA23.74630880
5MAP3K63.41934367
6SMG13.15433286
7MAP3K112.96196707
8IRAK32.89375436
9MATK2.47858291
10BMX2.34690790
11TYRO32.33818577
12PDGFRA2.33773146
13FGR2.06799358
14DYRK1B1.98326315
15NME21.96671393
16LMTK21.92935001
17PINK11.88628919
18PIM21.86099692
19LATS11.77857484
20CSK1.76938590
21AKT31.76218037
22PRKD21.73422151
23TRIB31.71492271
24CDK61.65264119
25LATS21.54655884
26TRPM71.48737089
27DAPK11.43790893
28ERN11.42231351
29RPS6KB21.40546289
30MAP3K101.40525965
31CDK71.35818412
32RIPK11.35095846
33UHMK11.30320239
34SIK11.26681420
35MST1R1.25661161
36MUSK1.23122772
37MAPKAPK31.21398111
38YES11.20149104
39PTK21.17386601
40GSK3A1.15717059
41TESK11.09477798
42MAPK111.08462812
43PIM11.06675681
44FER1.05245275
45MTOR1.03963186
46CDK121.03358092
47SCYL21.01617911
48MET1.00648648
49RPS6KC10.98790414
50RPS6KL10.98790414
51CDC42BPA0.96538626
52MAP3K30.94371324
53MST40.93640722
54IRAK20.88663424
55NME10.88285878
56PTK60.85377564
57PRPF4B0.85089939
58PRKD30.84080255
59RPS6KA60.83369228
60MAP2K20.81935600
61TAOK10.78792849
62CAMK1D0.78370006
63STK38L0.77174608
64PBK0.75581735
65FRK0.74560111
66EPHB20.74529460
67PRKCI0.71939586
68ARAF0.71786561
69STK30.71142719
70RPS6KA10.70339946
71RPS6KA20.69650960
72NEK60.65365973
73ILK0.62878151
74PRKAA10.62595451
75PAK40.61872057
76FGFR40.61034607
77NTRK10.58780535
78TESK20.58774298
79PKN20.58154314
80DYRK30.54846256
81PDGFRB0.54151750
82BCKDK0.53833472
83FGFR10.53655033
84EEF2K0.52080997
85EPHB10.52049406
86STK100.52018729
87MAP3K90.51962693
88PAK20.51766421
89CHEK20.51594421
90EIF2AK10.50474635
91HIPK20.50460062
92TTN0.49205408
93VRK20.49044535
94EGFR0.46368399
95ERBB40.46165869
96MAP3K10.46057686
97MAP3K20.45918460
98PDPK10.45268130
99SIK30.44038549
100PHKG20.41475927
101PHKG10.41475927
102MAP2K10.41146908
103PRKAA20.40890676
104MARK20.40867985
105TTK0.40187500
106RPS6KA40.39867570
107CAMK2G0.39069826
108MAP3K80.38291947
109CAMK1G0.37921692
110FLT30.37448852
111STK390.37363609
112TSSK60.37059354
113CDK80.36817195
114MAPKAPK20.35357481
115TAOK20.35051700
116PRKG20.34901413
117NEK10.34888731
118PLK10.34621635
119STK240.33160334
120MAPK10.32975517
121ERBB20.31335865
122ALK0.29603943
123BRAF0.28586020
124LRRK20.28579651
125AURKB0.28318659
126RET0.28173927
127MAPK30.27776674
128STK380.27392142
129CDK90.24624887
130CDK20.24219003
131AURKA0.24185109
132CDK40.23505369
133INSR0.23402980
134PRKD10.23239686
135CAMK2B0.22747570
136CHUK0.22445492
137AKT20.21403875
138GRK60.20510892
139MAPK80.20412817
140CHEK10.19162115

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.13712039
2Arginine biosynthesis_Homo sapiens_hsa002202.37764539
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.23672395
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.16013633
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15370022
6Fat digestion and absorption_Homo sapiens_hsa049752.09373068
7Adherens junction_Homo sapiens_hsa045201.98117663
8Arginine and proline metabolism_Homo sapiens_hsa003301.95926791
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94193042
10Hippo signaling pathway_Homo sapiens_hsa043901.93200223
11Bladder cancer_Homo sapiens_hsa052191.89403106
12Fatty acid metabolism_Homo sapiens_hsa012121.89052827
13Pentose phosphate pathway_Homo sapiens_hsa000301.86598289
14Nitrogen metabolism_Homo sapiens_hsa009101.82541787
15Hedgehog signaling pathway_Homo sapiens_hsa043401.81411515
16Base excision repair_Homo sapiens_hsa034101.77035007
17Folate biosynthesis_Homo sapiens_hsa007901.72303207
18Biosynthesis of amino acids_Homo sapiens_hsa012301.70574456
19Mismatch repair_Homo sapiens_hsa034301.69652466
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.69547171
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65063439
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64526938
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63172927
24Vitamin B6 metabolism_Homo sapiens_hsa007501.59864670
25Basal cell carcinoma_Homo sapiens_hsa052171.56080942
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51663353
27Tryptophan metabolism_Homo sapiens_hsa003801.48594386
28Lysine degradation_Homo sapiens_hsa003101.46804122
29Sulfur relay system_Homo sapiens_hsa041221.46093981
30Insulin signaling pathway_Homo sapiens_hsa049101.40164965
31mTOR signaling pathway_Homo sapiens_hsa041501.38736213
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37992515
33Fructose and mannose metabolism_Homo sapiens_hsa000511.36990702
34Notch signaling pathway_Homo sapiens_hsa043301.34861565
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26521591
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25938182
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25829368
38Selenocompound metabolism_Homo sapiens_hsa004501.24231126
39Tight junction_Homo sapiens_hsa045301.23711755
40Fatty acid degradation_Homo sapiens_hsa000711.20516329
41Sulfur metabolism_Homo sapiens_hsa009201.19854969
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18428020
43ErbB signaling pathway_Homo sapiens_hsa040121.17857934
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17438473
45Other glycan degradation_Homo sapiens_hsa005111.16212693
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15719260
47Histidine metabolism_Homo sapiens_hsa003401.15417012
48Mineral absorption_Homo sapiens_hsa049781.13638526
49Insulin resistance_Homo sapiens_hsa049311.12940511
50Bile secretion_Homo sapiens_hsa049761.12309114
51Hepatitis C_Homo sapiens_hsa051601.10601209
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09931780
53Caffeine metabolism_Homo sapiens_hsa002321.09540414
54Starch and sucrose metabolism_Homo sapiens_hsa005001.09381897
55N-Glycan biosynthesis_Homo sapiens_hsa005101.09225959
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07112766
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06535135
58p53 signaling pathway_Homo sapiens_hsa041151.05917719
59TGF-beta signaling pathway_Homo sapiens_hsa043501.05631925
60PPAR signaling pathway_Homo sapiens_hsa033201.05504939
61Galactose metabolism_Homo sapiens_hsa000521.05197467
62Sphingolipid metabolism_Homo sapiens_hsa006001.03558993
63Glutathione metabolism_Homo sapiens_hsa004801.02788392
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.99996161
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99779026
66Circadian rhythm_Homo sapiens_hsa047100.99541686
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98352120
68Non-small cell lung cancer_Homo sapiens_hsa052230.98037617
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94656210
70Renal cell carcinoma_Homo sapiens_hsa052110.93588730
71Small cell lung cancer_Homo sapiens_hsa052220.92783788
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91799406
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89467958
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88478114
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88369344
76Vibrio cholerae infection_Homo sapiens_hsa051100.87028120
77Chemical carcinogenesis_Homo sapiens_hsa052040.86432607
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86308670
79Axon guidance_Homo sapiens_hsa043600.84963986
80Tyrosine metabolism_Homo sapiens_hsa003500.83170400
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.82230158
82Vitamin digestion and absorption_Homo sapiens_hsa049770.81953965
83Prostate cancer_Homo sapiens_hsa052150.80742972
84Inositol phosphate metabolism_Homo sapiens_hsa005620.80699151
85Pancreatic cancer_Homo sapiens_hsa052120.80029441
86Steroid biosynthesis_Homo sapiens_hsa001000.79454583
87Thyroid cancer_Homo sapiens_hsa052160.78861944
88Phenylalanine metabolism_Homo sapiens_hsa003600.78522804
89Glucagon signaling pathway_Homo sapiens_hsa049220.77782916
90Complement and coagulation cascades_Homo sapiens_hsa046100.77542435
91Amoebiasis_Homo sapiens_hsa051460.77510000
92Prion diseases_Homo sapiens_hsa050200.77227793
93Proteoglycans in cancer_Homo sapiens_hsa052050.73550311
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72959298
95beta-Alanine metabolism_Homo sapiens_hsa004100.72792940
96ABC transporters_Homo sapiens_hsa020100.71426401
97Estrogen signaling pathway_Homo sapiens_hsa049150.71013533
98Wnt signaling pathway_Homo sapiens_hsa043100.70494202
99Glioma_Homo sapiens_hsa052140.69589753
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.69582479
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68665266
102Retinol metabolism_Homo sapiens_hsa008300.68390542
103DNA replication_Homo sapiens_hsa030300.67970497
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.66197110
105Renin-angiotensin system_Homo sapiens_hsa046140.65843445
106MicroRNAs in cancer_Homo sapiens_hsa052060.65279006
107VEGF signaling pathway_Homo sapiens_hsa043700.65013447
108Choline metabolism in cancer_Homo sapiens_hsa052310.64304442
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62997473
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61992691
111Glycerolipid metabolism_Homo sapiens_hsa005610.61521756
112AMPK signaling pathway_Homo sapiens_hsa041520.60892595
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60408510
114Focal adhesion_Homo sapiens_hsa045100.60079025
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60031693
116ECM-receptor interaction_Homo sapiens_hsa045120.59784097
117Carbon metabolism_Homo sapiens_hsa012000.58982195
118One carbon pool by folate_Homo sapiens_hsa006700.56113341
119Protein digestion and absorption_Homo sapiens_hsa049740.55687143
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.55249706
121Linoleic acid metabolism_Homo sapiens_hsa005910.53603635
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.53167644
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51469053
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51174793
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51054312
126Fatty acid elongation_Homo sapiens_hsa000620.50435208
127mRNA surveillance pathway_Homo sapiens_hsa030150.50303808
128Peroxisome_Homo sapiens_hsa041460.49141108
129Pyruvate metabolism_Homo sapiens_hsa006200.49097940
130Shigellosis_Homo sapiens_hsa051310.48589665
131GnRH signaling pathway_Homo sapiens_hsa049120.48224310
132Chronic myeloid leukemia_Homo sapiens_hsa052200.48101619
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.47788094
134Butanoate metabolism_Homo sapiens_hsa006500.47321161
135Propanoate metabolism_Homo sapiens_hsa006400.46774155
136RNA transport_Homo sapiens_hsa030130.46348723
137Endometrial cancer_Homo sapiens_hsa052130.46072875
138Pathways in cancer_Homo sapiens_hsa052000.45886644
139Endocytosis_Homo sapiens_hsa041440.44494013
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.44293653
141Acute myeloid leukemia_Homo sapiens_hsa052210.44052926
142Melanogenesis_Homo sapiens_hsa049160.43494988
143Melanoma_Homo sapiens_hsa052180.43349220

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