FAM83G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.49984184
2establishment of skin barrier (GO:0061436)9.46164654
3regulation of water loss via skin (GO:0033561)9.26668855
4bundle of His cell to Purkinje myocyte communication (GO:0086069)6.92976011
5multicellular organismal water homeostasis (GO:0050891)6.64134647
6keratinocyte differentiation (GO:0030216)6.02960396
7interferon-gamma secretion (GO:0072643)5.77428444
8intermediate filament organization (GO:0045109)5.76320911
9water homeostasis (GO:0030104)5.66288374
10peptide cross-linking (GO:0018149)5.17763198
11keratinocyte proliferation (GO:0043616)5.11243771
12keratinocyte development (GO:0003334)4.95457577
13intestinal epithelial cell development (GO:0060576)4.93911675
14epidermal cell differentiation (GO:0009913)4.83607723
15epidermis development (GO:0008544)4.70130130
16negative regulation of keratinocyte proliferation (GO:0010839)4.60064365
17COPI coating of Golgi vesicle (GO:0048205)4.40347182
18Golgi transport vesicle coating (GO:0048200)4.40347182
19skin morphogenesis (GO:0043589)4.29836808
20gap junction assembly (GO:0016264)4.21325929
21virion attachment to host cell (GO:0019062)3.96103263
22adhesion of symbiont to host cell (GO:0044650)3.96103263
23positive regulation of Cdc42 GTPase activity (GO:0043089)3.76569649
24protein localization to endosome (GO:0036010)3.75394868
25ectoderm development (GO:0007398)3.73093808
26sphingosine metabolic process (GO:0006670)3.61190502
27intermediate filament cytoskeleton organization (GO:0045104)3.58481161
28intermediate filament-based process (GO:0045103)3.48458990
29focal adhesion assembly (GO:0048041)3.45097894
30cell-substrate adherens junction assembly (GO:0007045)3.45097894
31negative regulation of fibrinolysis (GO:0051918)3.43444017
32columnar/cuboidal epithelial cell development (GO:0002066)3.42380654
33intestinal absorption (GO:0050892)3.41923176
34activation of Rac GTPase activity (GO:0032863)3.41185054
35adherens junction assembly (GO:0034333)3.40737708
36cell-substrate junction assembly (GO:0007044)3.39558369
37negative regulation of cell fate specification (GO:0009996)3.38908120
38oocyte development (GO:0048599)3.37034356
39positive regulation of epidermal cell differentiation (GO:0045606)3.29594113
40regulation of keratinocyte proliferation (GO:0010837)3.28870478
41diol metabolic process (GO:0034311)3.27356449
42adhesion of symbiont to host (GO:0044406)3.26898063
43positive regulation of epidermis development (GO:0045684)3.25972300
44cell adhesion mediated by integrin (GO:0033627)3.24989911
45urea cycle (GO:0000050)3.23965915
46urea metabolic process (GO:0019627)3.21726566
47atrioventricular valve morphogenesis (GO:0003181)3.21588039
48regulation of transforming growth factor beta2 production (GO:0032909)3.20461703
49sphingoid metabolic process (GO:0046519)3.20261449
50peptide catabolic process (GO:0043171)3.19895750
51regulation of keratinocyte differentiation (GO:0045616)3.19439500
52polarized epithelial cell differentiation (GO:0030859)3.16549875
53regulation of epidermis development (GO:0045682)3.15412625
54regulation of cardioblast differentiation (GO:0051890)3.14167854
55trophectodermal cell differentiation (GO:0001829)3.13791137
56glandular epithelial cell differentiation (GO:0002067)3.12206446
57regulation of ruffle assembly (GO:1900027)3.11651953
58cellular response to vitamin D (GO:0071305)3.07189845
59negative regulation of fatty acid transport (GO:2000192)3.06483189
60regulation of cholesterol homeostasis (GO:2000188)3.05106348
61proline biosynthetic process (GO:0006561)3.04791999
62skin development (GO:0043588)3.03323016
63apoptotic process involved in morphogenesis (GO:0060561)3.01937901
64intestinal cholesterol absorption (GO:0030299)3.00192561
65regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.94883400
66planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92873711
67renal absorption (GO:0070293)2.92026377
68regulation of fibrinolysis (GO:0051917)2.90586463
69epithelial cell-cell adhesion (GO:0090136)2.88949091
70maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88726834
71branching involved in mammary gland duct morphogenesis (GO:0060444)2.88307155
72COPII vesicle coating (GO:0048208)2.87232326
73glandular epithelial cell development (GO:0002068)2.86708084
74regulation of hair follicle development (GO:0051797)2.86330366
75regulation of chemokine secretion (GO:0090196)2.86105122
76gland morphogenesis (GO:0022612)2.85958655
77glucosamine-containing compound catabolic process (GO:1901072)2.83817305
78regulation of apoptotic process involved in morphogenesis (GO:1902337)2.80949133
79activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.79669804
80linoleic acid metabolic process (GO:0043651)2.78852864
81tight junction assembly (GO:0070830)2.77985854
82epithelial cell fate commitment (GO:0072148)2.77519106
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77288325
84citrulline biosynthetic process (GO:0019240)2.76763932
85regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76244228
86regulation of epidermal cell differentiation (GO:0045604)2.74096651
87negative regulation of cell fate commitment (GO:0010454)2.73850332
88hormone catabolic process (GO:0042447)2.71324558
89eyelid development in camera-type eye (GO:0061029)2.70647219
90fibrinolysis (GO:0042730)2.69160977
91regulation of transforming growth factor beta1 production (GO:0032908)2.69102742
92nitrogen cycle metabolic process (GO:0071941)2.68802016
93cellular protein complex localization (GO:0034629)2.68487061
94ventricular cardiac muscle cell action potential (GO:0086005)2.68236806
95regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.67907418
96regulation of mammary gland epithelial cell proliferation (GO:0033599)2.66415662
97hair follicle morphogenesis (GO:0031069)2.66330286
98positive regulation of nuclease activity (GO:0032075)2.65852613
99dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.64295724
100regulation of translational termination (GO:0006449)2.64125276
101regulation of phospholipase A2 activity (GO:0032429)2.63876353
102type B pancreatic cell development (GO:0003323)2.62670272
103protein carboxylation (GO:0018214)2.62648586
104peptidyl-glutamic acid carboxylation (GO:0017187)2.62648586
105regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.62114844
106endocrine pancreas development (GO:0031018)2.61522158
107negative regulation of viral release from host cell (GO:1902187)2.61420967
108phosphatidylinositol acyl-chain remodeling (GO:0036149)2.61188036
109surfactant homeostasis (GO:0043129)2.59999571
110proline metabolic process (GO:0006560)2.59397423
111negative regulation of glycoprotein biosynthetic process (GO:0010561)2.58297174
112regulation of type B pancreatic cell apoptotic process (GO:2000674)2.57442131
113protein complex localization (GO:0031503)2.54999985
114glucose 6-phosphate metabolic process (GO:0051156)2.54702620
115negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.54573599
116establishment of apical/basal cell polarity (GO:0035089)2.54558341
117mitotic G1 DNA damage checkpoint (GO:0031571)2.53480608
118epithelial cell differentiation involved in prostate gland development (GO:0060742)2.51506143
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.50994343
120protein retention in ER lumen (GO:0006621)2.50406955
121embryonic process involved in female pregnancy (GO:0060136)2.50334251
122basement membrane organization (GO:0071711)2.50244943
123regulation of cell fate specification (GO:0042659)2.49890314
124establishment of planar polarity (GO:0001736)2.48380038
125establishment of tissue polarity (GO:0007164)2.48380038
126regulation of early endosome to late endosome transport (GO:2000641)2.48357875
127regulation of hippo signaling (GO:0035330)2.48250758
128regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.47272968
129mitotic G1/S transition checkpoint (GO:0044819)2.46647083
130regulation of Cdc42 GTPase activity (GO:0043088)2.46160353
131epithelium development (GO:0060429)2.46032494
132peptide hormone processing (GO:0016486)2.45320395
133positive regulation of interleukin-8 secretion (GO:2000484)2.45208193
134low-density lipoprotein particle clearance (GO:0034383)2.45138468
135regulation of nuclease activity (GO:0032069)2.44795105
136cardiac right ventricle morphogenesis (GO:0003215)2.44256621
137cell junction assembly (GO:0034329)2.43509501
138endodermal cell differentiation (GO:0035987)2.42665716
139positive regulation of hormone biosynthetic process (GO:0046886)2.42423208
140cell junction organization (GO:0034330)2.41032664
141dorsal/ventral axis specification (GO:0009950)2.40650209
142negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.39829002
143positive regulation of keratinocyte differentiation (GO:0045618)2.38905785
144protein localization to microtubule (GO:0035372)2.38871143
145cellular response to vitamin (GO:0071295)2.38164385
146regulation of endothelial cell chemotaxis (GO:2001026)2.37922609
147regulation of translational fidelity (GO:0006450)2.37836594
148regulation of bile acid biosynthetic process (GO:0070857)2.37137437
149mesodermal cell differentiation (GO:0048333)2.34969438
150Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.33258007
151regulation of cholesterol biosynthetic process (GO:0045540)2.32024990
152nucleotide-sugar biosynthetic process (GO:0009226)2.30759103
153desmosome organization (GO:0002934)11.8822651
154hemidesmosome assembly (GO:0031581)10.0457548
155hair cycle (GO:0042633)10.0204153
156molting cycle (GO:0042303)10.0204153

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.12351602
2ESR1_21235772_ChIP-Seq_MCF-7_Human2.84145653
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.68931423
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.62292502
5ZNF263_19887448_ChIP-Seq_K562_Human2.49371790
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.43157621
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34203338
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.21728324
9FOXO3_23340844_ChIP-Seq_DLD1_Human2.05688432
10TP63_17297297_ChIP-ChIP_HaCaT_Human14.9653876
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.96241041
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.96241041
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.91313653
14KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.90814201
15ATF3_27146783_Chip-Seq_COLON_Human1.89408132
16RACK7_27058665_Chip-Seq_MCF-7_Human1.88472890
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86658162
18GATA6_25053715_ChIP-Seq_YYC3_Human1.81307276
19HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77731693
20KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.77306386
21SOX2_27498859_Chip-Seq_STOMACH_Mouse1.76637106
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75418318
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.65602274
24MYC_22102868_ChIP-Seq_BL_Human1.65423167
25CLOCK_20551151_ChIP-Seq_293T_Human1.61115946
26E2F7_22180533_ChIP-Seq_HELA_Human1.58166905
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55753916
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53990173
29TP53_22127205_ChIP-Seq_IMR90_Human1.52490968
30* GATA4_25053715_ChIP-Seq_YYC3_Human1.52373578
31ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.50729166
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46176551
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45862092
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45354896
35GATA3_24758297_ChIP-Seq_MCF-7_Human1.41934248
36VDR_21846776_ChIP-Seq_THP-1_Human1.41299217
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36486859
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36398155
39SOX2_20726797_ChIP-Seq_SW620_Human1.35187153
40UBF1/2_26484160_Chip-Seq_HMECs_Human1.33274979
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33059047
42CDX2_20551321_ChIP-Seq_CACO-2_Human1.33013489
43* TP63_22573176_ChIP-Seq_HFKS_Human1.31415727
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31363049
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31049318
46FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30838882
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30145931
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27331515
49KLF5_25053715_ChIP-Seq_YYC3_Human1.26308140
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25930874
51GATA1_22025678_ChIP-Seq_K562_Human1.23231234
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.20480576
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18913510
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18280801
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17945712
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16655231
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16547563
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16477700
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.16032101
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15497060
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.13348264
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.12521202
63SMC4_20622854_ChIP-Seq_HELA_Human1.11951903
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09936105
65LXR_22292898_ChIP-Seq_THP-1_Human1.08255443
66CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08142691
67* KDM2B_26808549_Chip-Seq_DND41_Human1.07829857
68SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06215706
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06147401
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06125458
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05114613
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04768594
73TP63_23658742_ChIP-Seq_EP156T_Human1.04609835
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04304301
75EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03617940
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02329380
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01734739
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00621354
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00506875
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99551882
81ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98684798
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98620214
83RXR_22158963_ChIP-Seq_LIVER_Mouse0.98569158
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97832985
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97032725
86CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96896397
87* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95996204
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95977630
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94244967
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94213647
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93577426
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.93313802
93LXR_22158963_ChIP-Seq_LIVER_Mouse0.92565846
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92066314
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92043698
96CHD1_26751641_Chip-Seq_LNCaP_Human0.91337808
97NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91279183
98BCOR_27268052_Chip-Seq_Bcells_Human0.90892864
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90845195
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90411835
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89537125
102MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89337935
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89027211
104HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88585563
105AR_21909140_ChIP-Seq_LNCAP_Human0.88226840
106* CTCF_20526341_ChIP-Seq_ESCs_Human0.87075457
107CTCF_27219007_Chip-Seq_Bcells_Human0.86468993
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86178135
109EGR1_19374776_ChIP-ChIP_THP-1_Human0.86063590
110CREB1_26743006_Chip-Seq_LNCaP_Human0.86057011
111CJUN_26792858_Chip-Seq_BT549_Human0.85297576
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84659948
113TCF4_18268006_ChIP-ChIP_LS174T_Human0.84403006
114KDM2B_26808549_Chip-Seq_K562_Human0.83733133
115* SA1_27219007_Chip-Seq_ERYTHROID_Human0.83492937
116GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83343499
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82714822
118P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82394780
119* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81720934
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81489887
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81003125
122TCF7_22412390_ChIP-Seq_EML_Mouse0.80605859
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79924802
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75417126
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75360627
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73665132
127YY1_22570637_ChIP-Seq_MALME-3M_Human0.72870268
128ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71905821
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71771377
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.71696887
131TP53_20018659_ChIP-ChIP_R1E_Mouse0.71519063
132FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.70324832
133RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.69076674
134* P68_20966046_ChIP-Seq_HELA_Human0.69031920
135ERG_20517297_ChIP-Seq_VCAP_Human0.67234187
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.67035906
137GATA6_21074721_ChIP-Seq_CACO-2_Human0.66191911
138FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.65896368
139NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.64713306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.65284120
2MP0002254_reproductive_system_inflammat5.02619559
3MP0010234_abnormal_vibrissa_follicle4.59120117
4MP0000579_abnormal_nail_morphology4.15072452
5MP0005275_abnormal_skin_tensile3.65465708
6MP0005501_abnormal_skin_physiology3.52578682
7MP0003941_abnormal_skin_development3.40808540
8MP0002098_abnormal_vibrissa_morphology3.38316710
9MP0000383_abnormal_hair_follicle3.17748913
10MP0003705_abnormal_hypodermis_morpholog3.01708760
11MP0002060_abnormal_skin_morphology2.98625729
12MP0001216_abnormal_epidermal_layer2.95668868
13MP0002877_abnormal_melanocyte_morpholog2.93817540
14MP0010678_abnormal_skin_adnexa2.93062401
15MP0003453_abnormal_keratinocyte_physiol2.80203541
16MP0000647_abnormal_sebaceous_gland2.74328311
17MP0004264_abnormal_extraembryonic_tissu2.58082207
18MP0000467_abnormal_esophagus_morphology2.45040547
19MP0000377_abnormal_hair_follicle2.34793209
20MP0000427_abnormal_hair_cycle2.22435683
21MP0010771_integument_phenotype2.22193737
22MP0001346_abnormal_lacrimal_gland2.15512189
23MP0004947_skin_inflammation2.12707405
24MP0003566_abnormal_cell_adhesion2.05921827
25MP0002234_abnormal_pharynx_morphology2.05319586
26MP0005409_darkened_coat_color2.00698407
27MP0005360_urolithiasis1.99755358
28MP0005257_abnormal_intraocular_pressure1.97585304
29MP0000762_abnormal_tongue_morphology1.93528500
30MP0002139_abnormal_hepatobiliary_system1.79654008
31MP0010352_gastrointestinal_tract_polyps1.65578471
32MP0001849_ear_inflammation1.65414659
33MP0004381_abnormal_hair_follicle1.61830293
34MP0000678_abnormal_parathyroid_gland1.57957812
35MP0000566_synostosis1.47321320
36MP0009931_abnormal_skin_appearance1.41254021
37MP0008438_abnormal_cutaneous_collagen1.41068950
38MP0009379_abnormal_foot_pigmentation1.38360652
39MP0004185_abnormal_adipocyte_glucose1.37725649
40MP0009053_abnormal_anal_canal1.36903440
41MP0009840_abnormal_foam_cell1.35169773
42MP0001191_abnormal_skin_condition1.30007605
43MP0001243_abnormal_dermal_layer1.28588275
44MP0000367_abnormal_coat/_hair1.27210923
45MP0004858_abnormal_nervous_system1.24670334
46MP0002089_abnormal_postnatal_growth/wei1.24075758
47MP0003300_gastrointestinal_ulcer1.22534275
48MP0003950_abnormal_plasma_membrane1.21683920
49MP0010030_abnormal_orbit_morphology1.15755088
50MP0004233_abnormal_muscle_weight1.13615124
51MP0005076_abnormal_cell_differentiation1.12436990
52MP0005623_abnormal_meninges_morphology1.11798698
53MP0005451_abnormal_body_composition1.10620206
54MP0000613_abnormal_salivary_gland1.09795584
55MP0008789_abnormal_olfactory_epithelium1.09282544
56MP0005023_abnormal_wound_healing1.09116945
57MP0003091_abnormal_cell_migration1.06025072
58MP0000462_abnormal_digestive_system1.05557366
59MP0001666_abnormal_nutrient_absorption1.04098301
60MP0000538_abnormal_urinary_bladder1.03964557
61MP0005365_abnormal_bile_salt1.03446292
62MP0009780_abnormal_chondrocyte_physiolo1.03188598
63MP0002909_abnormal_adrenal_gland1.01700313
64MP0000858_altered_metastatic_potential1.01312544
65MP0000537_abnormal_urethra_morphology0.98094958
66MP0003283_abnormal_digestive_organ0.89799202
67MP0008961_abnormal_basal_metabolism0.89192691
68MP0001348_abnormal_lacrimal_gland0.88622915
69MP0002693_abnormal_pancreas_physiology0.86303237
70MP0005499_abnormal_olfactory_system0.84698813
71MP0005394_taste/olfaction_phenotype0.84698813
72MP0006054_spinal_hemorrhage0.82808136
73MP0008260_abnormal_autophagy0.80420075
74MP0001340_abnormal_eyelid_morphology0.79920623
75MP0001730_embryonic_growth_arrest0.79292815
76MP0003191_abnormal_cellular_cholesterol0.79256916
77MP0001851_eye_inflammation0.78470948
78MP0000465_gastrointestinal_hemorrhage0.78418925
79MP0002896_abnormal_bone_mineralization0.75786360
80MP0005058_abnormal_lysosome_morphology0.75258925
81MP0003119_abnormal_digestive_system0.75250042
82MP0001944_abnormal_pancreas_morphology0.75121078
83MP0010368_abnormal_lymphatic_system0.74469938
84MP0002697_abnormal_eye_size0.74434737
85MP0001661_extended_life_span0.73049022
86MP0000627_abnormal_mammary_gland0.72935524
87MP0004019_abnormal_vitamin_homeostasis0.72221925
88MP0003183_abnormal_peptide_metabolism0.71919992
89MP0000003_abnormal_adipose_tissue0.71715133
90MP0005085_abnormal_gallbladder_physiolo0.70333723
91MP0009672_abnormal_birth_weight0.68649728
92MP0002111_abnormal_tail_morphology0.68337262
93MP0005367_renal/urinary_system_phenotyp0.67483830
94MP0000516_abnormal_urinary_system0.67483830
95MP0000470_abnormal_stomach_morphology0.66654142
96MP0002177_abnormal_outer_ear0.66468519
97MP0003755_abnormal_palate_morphology0.66121348
98MP0003693_abnormal_embryo_hatching0.65847181
99MP0004197_abnormal_fetal_growth/weight/0.65313637
100MP0002249_abnormal_larynx_morphology0.65236956
101MP0002086_abnormal_extraembryonic_tissu0.64535381
102MP0004782_abnormal_surfactant_physiolog0.64175319
103MP0002009_preneoplasia0.63383786
104MP0000733_abnormal_muscle_development0.62020388
105MP0003111_abnormal_nucleus_morphology0.61768533
106MP0000490_abnormal_crypts_of0.58449552
107MP0000013_abnormal_adipose_tissue0.57456890
108MP0000350_abnormal_cell_proliferation0.56875593
109MP0001915_intracranial_hemorrhage0.56160434
110MP0005666_abnormal_adipose_tissue0.55713132
111MP0003866_abnormal_defecation0.55267304
112MP0005621_abnormal_cell_physiology0.55132870
113MP0002233_abnormal_nose_morphology0.54488021
114MP0000767_abnormal_smooth_muscle0.53996303
115MP0005197_abnormal_uvea_morphology0.53666074
116MP0005220_abnormal_exocrine_pancreas0.53265351
117MP0009333_abnormal_splenocyte_physiolog0.53244175
118MP0003937_abnormal_limbs/digits/tail_de0.52806173
119MP0000477_abnormal_intestine_morphology0.52805324
120MP0003984_embryonic_growth_retardation0.52207925
121MP0001672_abnormal_embryogenesis/_devel0.52177231
122MP0009643_abnormal_urine_homeostasis0.51747849
123MP0004043_abnormal_pH_regulation0.50564763
124MP0005375_adipose_tissue_phenotype0.50431810
125MP0001784_abnormal_fluid_regulation0.49561163
126MP0000428_abnormal_craniofacial_morphol0.48683784
127MP0005248_abnormal_Harderian_gland0.47477298
128MP0010155_abnormal_intestine_physiology0.47064010
129MP0003315_abnormal_perineum_morphology0.46043134
130MP0009384_cardiac_valve_regurgitation0.46011893
131MP0005310_abnormal_salivary_gland0.44037621
132MP0000432_abnormal_head_morphology0.43720443
133MP0003763_abnormal_thymus_physiology0.43577624
134MP0001756_abnormal_urination0.43294538
135MP0004957_abnormal_blastocyst_morpholog0.42884972
136MP0004272_abnormal_basement_membrane0.41820118
137MP0003195_calcinosis0.37639582

Predicted human phenotypes

RankGene SetZ-score
1Plantar hyperkeratosis (HP:0007556)6.62514490
2Fragile nails (HP:0001808)6.40601390
3Hypotrichosis (HP:0001006)6.35259601
4Milia (HP:0001056)6.18283867
5Woolly hair (HP:0002224)6.09750222
6Onycholysis (HP:0001806)5.91182276
7Right ventricular cardiomyopathy (HP:0011663)5.82314415
8Pili torti (HP:0003777)5.73687980
9Palmoplantar hyperkeratosis (HP:0000972)5.59748337
10Palmar hyperkeratosis (HP:0010765)5.29939066
11Abnormality of nail color (HP:0100643)5.11255938
12Increased IgE level (HP:0003212)5.00646822
13Lip pit (HP:0100267)4.70295174
14Nail dystrophy (HP:0008404)4.40597576
15Abnormal blistering of the skin (HP:0008066)4.02527912
16Atrophic scars (HP:0001075)4.00422180
17Thick nail (HP:0001805)3.83422697
18Alopecia of scalp (HP:0002293)3.83049037
19Abnormal hair laboratory examination (HP:0003328)3.73178582
20Erythema (HP:0010783)3.11976864
21Congenital ichthyosiform erythroderma (HP:0007431)3.07184812
22Natal tooth (HP:0000695)3.05972525
23Premature rupture of membranes (HP:0001788)2.98565449
24Conjunctival hamartoma (HP:0100780)2.94304702
25Selective tooth agenesis (HP:0001592)2.92895948
26Ridged nail (HP:0001807)2.91050446
27Deep venous thrombosis (HP:0002625)2.88172243
28Curly hair (HP:0002212)2.87414185
29Erythroderma (HP:0001019)2.85668849
30Abnormality of the gastric mucosa (HP:0004295)2.79735078
31Sparse eyelashes (HP:0000653)2.74681584
32Hypoplastic labia majora (HP:0000059)2.72129133
33Ulnar bowing (HP:0003031)2.70736314
34Advanced eruption of teeth (HP:0006288)2.69859958
35Abnormality of the distal phalanges of the toes (HP:0010182)2.67401759
36Fragile skin (HP:0001030)2.67011756
37Hyperacusis (HP:0010780)2.59789903
38Sparse scalp hair (HP:0002209)2.58909656
39Hypoplasia of dental enamel (HP:0006297)2.56288508
40Hyperinsulinemic hypoglycemia (HP:0000825)2.52979480
41Unilateral renal agenesis (HP:0000122)2.52270548
42Ectropion (HP:0000656)2.51107992
43Aplasia cutis congenita (HP:0001057)2.49654046
44Achilles tendon contracture (HP:0001771)2.45955834
45Distal lower limb amyotrophy (HP:0008944)2.44410932
46Abnormality of the labia majora (HP:0012881)2.43220243
47Amelogenesis imperfecta (HP:0000705)2.42728548
48Abnormality of the Achilles tendon (HP:0005109)2.41472520
49Hyperglycemia (HP:0003074)2.39529547
50Protrusio acetabuli (HP:0003179)2.39489250
51Short nail (HP:0001799)2.37766874
52Pterygium (HP:0001059)2.37702686
53Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.36633839
54Broad face (HP:0000283)2.35985623
55Trismus (HP:0000211)2.34982799
56Symptomatic seizures (HP:0011145)2.34073266
57Popliteal pterygium (HP:0009756)2.31777817
58Abnormality of the neuromuscular junction (HP:0003398)2.30881138
59Fatigable weakness (HP:0003473)2.30881138
60Ventricular tachycardia (HP:0004756)2.26994731
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.26646743
62Palmoplantar keratoderma (HP:0000982)2.24775303
63Brittle hair (HP:0002299)2.20492201
64Oral leukoplakia (HP:0002745)2.19252838
65Hypohidrosis (HP:0000966)2.17626602
66Abnormal pancreas size (HP:0012094)2.16140099
67Increased connective tissue (HP:0009025)2.12052317
68Anonychia (HP:0001798)2.10873584
69Insulin-resistant diabetes mellitus (HP:0000831)2.10632254
70Squamous cell carcinoma (HP:0002860)2.09779184
71Hypoglycemic seizures (HP:0002173)2.09394845
72Corneal erosion (HP:0200020)2.08569182
73Hypoglycemic coma (HP:0001325)2.07323324
74Breast hypoplasia (HP:0003187)2.06154965
75Septate vagina (HP:0001153)2.05277671
76Blepharitis (HP:0000498)2.03252154
77Distal lower limb muscle weakness (HP:0009053)2.02613003
78Abnormality of oral frenula (HP:0000190)1.95219660
79Ventricular fibrillation (HP:0001663)1.94693216
80Down-sloping shoulders (HP:0200021)1.94219563
81Slow-growing hair (HP:0002217)1.93879731
82Abnormality of hair growth rate (HP:0011363)1.93879731
83Distal upper limb amyotrophy (HP:0007149)1.93852973
84Upper limb amyotrophy (HP:0009129)1.93852973
85Vertebral compression fractures (HP:0002953)1.91179053
86Abnormality of the distal phalanx of the thumb (HP:0009617)1.90553693
87Villous atrophy (HP:0011473)1.90030730
88Abnormality of small intestinal villus morphology (HP:0011472)1.90030730
89Nasolacrimal duct obstruction (HP:0000579)1.89802270
90Oligodontia (HP:0000677)1.87348971
91Abnormality of carpal bone ossification (HP:0006257)1.87225618
92Cervical subluxation (HP:0003308)1.85505000
93Pruritus (HP:0000989)1.84700918
94Esophageal atresia (HP:0002032)1.84364484
95Ureteral duplication (HP:0000073)1.82074625
96Parakeratosis (HP:0001036)1.81908893
97Premature loss of primary teeth (HP:0006323)1.81843530
98Mildly elevated creatine phosphokinase (HP:0008180)1.81351882
99Hamartoma of the eye (HP:0010568)1.81152344
100Abnormality of the salivary glands (HP:0010286)1.80865350
101Thin bony cortex (HP:0002753)1.80399024
102Vascular calcification (HP:0004934)1.80140134
103Myopathic facies (HP:0002058)1.79442570
104Abnormal ossification of hand bones (HP:0005921)1.78735425
105Pustule (HP:0200039)1.78152630
106Hyporeflexia of lower limbs (HP:0002600)1.78100923
107Aplasia/hypoplasia of the uterus (HP:0008684)1.77232711
108Acanthosis nigricans (HP:0000956)1.76038811
109Cardiovascular calcification (HP:0011915)1.73818506
110Abnormality of the fingernails (HP:0001231)1.73612300
111Elbow flexion contracture (HP:0002987)1.73350432
112Follicular hyperkeratosis (HP:0007502)1.72620508
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.72308117
114Bronchomalacia (HP:0002780)1.71957325
115Deviation of the thumb (HP:0009603)1.71050223
116Dehydration (HP:0001944)1.70354938
117Abdominal distention (HP:0003270)1.70348166
118Absent eyelashes (HP:0000561)1.70284249
119Shallow orbits (HP:0000586)1.69341288
120Flat acetabular roof (HP:0003180)1.69279751
121Malnutrition (HP:0004395)1.68600790
122Skin pits (HP:0100276)1.67681881
123Difficulty climbing stairs (HP:0003551)1.67649074
124Late onset (HP:0003584)1.64918473
125Entropion (HP:0000621)1.64896701
126Spinal rigidity (HP:0003306)1.63393667
127Bowing of the arm (HP:0006488)1.63390050
128Bowed forearm bones (HP:0003956)1.63390050
129Ankle contracture (HP:0006466)1.63285627
130Osteolytic defects of the hand bones (HP:0009699)1.63232042
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.63232042
13211 pairs of ribs (HP:0000878)1.62432172
133Abnormality of the axillary hair (HP:0100134)1.61369640
134Abnormality of secondary sexual hair (HP:0009888)1.61369640
135Upper limb muscle weakness (HP:0003484)1.61326398
136Congenital, generalized hypertrichosis (HP:0004540)1.61216614
137Carious teeth (HP:0000670)1.61207828
138Coronal craniosynostosis (HP:0004440)1.60550500
139Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.60478996
140Ankyloglossia (HP:0010296)1.59877647
141Hypoplasia of the uterus (HP:0000013)1.58967684
142Hyperhidrosis (HP:0000975)1.58817201
143Bladder diverticulum (HP:0000015)1.58479740
144Long palpebral fissure (HP:0000637)1.58470206
145Poikiloderma (HP:0001029)1.56583341
146Abnormality of glutamine family amino acid metabolism (HP:0010902)1.55735198
147Ileus (HP:0002595)1.55472229
148Neonatal death (HP:0003811)1.53418013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.78578131
2MAP3K34.32430226
3SMG13.76580668
4IRAK33.50094889
5MST1R3.44390646
6MAP3K23.29910174
7MAPKAPK32.99246799
8ERN12.98415316
9LATS12.87481962
10RPS6KB22.59587484
11ICK2.56518163
12FER2.37473611
13MST42.16340192
14MAPK152.09074602
15MET2.08960209
16PASK2.07195297
17MAP2K22.06506133
18TRIB32.06206474
19TTN1.98860524
20PTK61.90310675
21NME21.85526062
22INSRR1.73127673
23TAOK11.63474593
24EEF2K1.61676517
25EPHA31.60806162
26PTK21.58039743
27PRPF4B1.56182497
28FRK1.50895302
29STK101.49812203
30FGFR41.47050319
31TAOK31.46442593
32NME11.45840230
33MAP3K11.45554957
34PRKCI1.44952508
35LMTK21.39953999
36RPS6KA41.37026942
37STK38L1.29116826
38EPHB21.24192455
39EPHB11.23619435
40LRRK21.23124662
41HIPK21.22141970
42PIM21.21662461
43RIPK11.19031256
44SCYL21.10677816
45CDK121.09197376
46MAP3K111.07991230
47DYRK1B1.05585081
48ARAF1.05409263
49NLK1.02571972
50PIK3CG0.95626728
51TAOK20.94418371
52TTK0.89576322
53RPS6KA20.87663810
54STK30.85474744
55CHUK0.83106340
56MAP3K100.81265546
57FGFR10.80496460
58PRKD30.80388229
59LATS20.76717359
60CDK60.76403417
61STK240.76259832
62PDGFRA0.75687267
63MAP2K10.75121429
64MAP3K60.73890404
65PLK40.73882829
66CDK70.73270807
67TYK20.71874445
68MAPKAPK20.71658279
69MAP3K80.71614912
70NTRK10.69930297
71MAPK110.68035622
72TESK10.67071358
73MAP2K30.66950002
74MTOR0.66729848
75PBK0.66600581
76PAK20.66287114
77MAP3K130.65361592
78ERBB40.64227961
79STK380.62466056
80MAP3K140.61985452
81MAP3K70.61286212
82SIK10.59362407
83PKN20.57658974
84CAMK1D0.57163804
85TGFBR10.57016787
86FGFR30.56674123
87CDC42BPA0.56414685
88RPS6KL10.55947938
89RPS6KC10.55947938
90MAP2K60.53994541
91MELK0.52805971
92TESK20.52787936
93ABL20.50403212
94BRSK20.50206708
95ITK0.49817447
96TRPM70.47408516
97BRD40.45233050
98AURKA0.44224314
99AURKB0.43788114
100AKT20.43217572
101JAK30.42538906
102CDK80.42431670
103JAK20.42018947
104RPS6KA60.41603309
105RPS6KA10.41187148
106FLT30.40053217
107ILK0.40001462
108DDR20.39262640
109CDK40.39009998
110GSK3A0.38837686
111DYRK30.38815811
112PRKG20.38701819
113KSR20.38606929
114STK110.37025793
115PRKD10.35407604
116PDPK10.35311598
117ERBB20.34970649
118CDK90.34287101
119TAF10.34021494
120BUB10.33600864
121NEK20.33428495
122CHEK20.32357689
123WNK40.32132557
124IRAK20.32123201
125ALK0.32049726
126RET0.30380083
127BMX0.28695705
128MOS0.28267330
129BCR0.27908139
130MAP3K90.27661495
131BRAF0.26413417
132BMPR20.26194045
133PAK40.25666366
134PRKD20.25600992
135MAP3K50.24557445
136TSSK60.24429579
137PDGFRB0.23742797
138FGFR20.22405546

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.68651897
2Fat digestion and absorption_Homo sapiens_hsa049752.67138069
3Linoleic acid metabolism_Homo sapiens_hsa005912.41483833
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27610206
5Sulfur metabolism_Homo sapiens_hsa009202.25518982
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.01215149
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.92815023
8Cyanoamino acid metabolism_Homo sapiens_hsa004601.89134675
9Phenylalanine metabolism_Homo sapiens_hsa003601.88223253
10Arginine biosynthesis_Homo sapiens_hsa002201.84929391
11Fructose and mannose metabolism_Homo sapiens_hsa000511.84317997
12Central carbon metabolism in cancer_Homo sapiens_hsa052301.83726568
13Histidine metabolism_Homo sapiens_hsa003401.83687902
14Sulfur relay system_Homo sapiens_hsa041221.83453985
15Basal cell carcinoma_Homo sapiens_hsa052171.83037869
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.82686926
17Bladder cancer_Homo sapiens_hsa052191.82207510
18Sphingolipid metabolism_Homo sapiens_hsa006001.76361585
19Adherens junction_Homo sapiens_hsa045201.70369643
20Protein digestion and absorption_Homo sapiens_hsa049741.68831813
21Hippo signaling pathway_Homo sapiens_hsa043901.67703558
22Biosynthesis of amino acids_Homo sapiens_hsa012301.66383864
23Vitamin B6 metabolism_Homo sapiens_hsa007501.57687868
24Folate biosynthesis_Homo sapiens_hsa007901.50362949
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48075021
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46926054
27Pentose phosphate pathway_Homo sapiens_hsa000301.44199788
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43233576
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41480781
30p53 signaling pathway_Homo sapiens_hsa041151.37707965
31Vitamin digestion and absorption_Homo sapiens_hsa049771.37671446
32Arachidonic acid metabolism_Homo sapiens_hsa005901.37220608
33Tight junction_Homo sapiens_hsa045301.36652621
34Hedgehog signaling pathway_Homo sapiens_hsa043401.36546944
35ECM-receptor interaction_Homo sapiens_hsa045121.36033184
36Mineral absorption_Homo sapiens_hsa049781.35817742
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35415990
38Thyroid cancer_Homo sapiens_hsa052161.33956074
39Complement and coagulation cascades_Homo sapiens_hsa046101.33711100
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33213801
41Selenocompound metabolism_Homo sapiens_hsa004501.33122711
42Circadian rhythm_Homo sapiens_hsa047101.30781362
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22813979
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21521710
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20591081
46Antigen processing and presentation_Homo sapiens_hsa046121.17249344
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13432966
48Insulin resistance_Homo sapiens_hsa049311.11206348
49Proteoglycans in cancer_Homo sapiens_hsa052051.09730512
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06410138
51Chemical carcinogenesis_Homo sapiens_hsa052041.05064729
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04308736
53Caffeine metabolism_Homo sapiens_hsa002321.03269496
54Prion diseases_Homo sapiens_hsa050201.02363376
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00524195
56Toxoplasmosis_Homo sapiens_hsa051451.00436717
57Pancreatic secretion_Homo sapiens_hsa049721.00417884
58Small cell lung cancer_Homo sapiens_hsa052220.99963759
59Dorso-ventral axis formation_Homo sapiens_hsa043200.98800243
60Protein export_Homo sapiens_hsa030600.98464257
61Lysine degradation_Homo sapiens_hsa003100.97819781
62ABC transporters_Homo sapiens_hsa020100.96937353
63Prolactin signaling pathway_Homo sapiens_hsa049170.95083272
64Steroid biosynthesis_Homo sapiens_hsa001000.94501451
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94463547
66MicroRNAs in cancer_Homo sapiens_hsa052060.94401189
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94209758
68Ribosome_Homo sapiens_hsa030100.92952020
69Arginine and proline metabolism_Homo sapiens_hsa003300.92783004
70Galactose metabolism_Homo sapiens_hsa000520.92734293
71Retinol metabolism_Homo sapiens_hsa008300.89690745
72Amoebiasis_Homo sapiens_hsa051460.88476307
73Starch and sucrose metabolism_Homo sapiens_hsa005000.85801383
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85497096
75TGF-beta signaling pathway_Homo sapiens_hsa043500.85198973
76VEGF signaling pathway_Homo sapiens_hsa043700.81955678
77Ether lipid metabolism_Homo sapiens_hsa005650.80788977
78PPAR signaling pathway_Homo sapiens_hsa033200.80358809
79N-Glycan biosynthesis_Homo sapiens_hsa005100.79972053
80Glutathione metabolism_Homo sapiens_hsa004800.77390609
81Carbon metabolism_Homo sapiens_hsa012000.76968375
82Acute myeloid leukemia_Homo sapiens_hsa052210.76175376
83Insulin signaling pathway_Homo sapiens_hsa049100.75385197
84Prostate cancer_Homo sapiens_hsa052150.72747349
85Type II diabetes mellitus_Homo sapiens_hsa049300.71162710
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.68773467
87Tyrosine metabolism_Homo sapiens_hsa003500.66073270
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.65629039
89AMPK signaling pathway_Homo sapiens_hsa041520.65589515
90Chronic myeloid leukemia_Homo sapiens_hsa052200.65067441
91ErbB signaling pathway_Homo sapiens_hsa040120.65035388
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.64680676
93HTLV-I infection_Homo sapiens_hsa051660.63302413
94Fatty acid biosynthesis_Homo sapiens_hsa000610.62566601
95Renin-angiotensin system_Homo sapiens_hsa046140.61238087
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61020998
97Notch signaling pathway_Homo sapiens_hsa043300.60113295
98Shigellosis_Homo sapiens_hsa051310.59485728
99Endometrial cancer_Homo sapiens_hsa052130.59248833
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58710547
101Apoptosis_Homo sapiens_hsa042100.58188408
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56997368
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56944047
104Hepatitis C_Homo sapiens_hsa051600.55270209
105Legionellosis_Homo sapiens_hsa051340.55097050
106mTOR signaling pathway_Homo sapiens_hsa041500.54864175
107Melanogenesis_Homo sapiens_hsa049160.53420041
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.52280793
109Vibrio cholerae infection_Homo sapiens_hsa051100.51789348
110Non-small cell lung cancer_Homo sapiens_hsa052230.50919242
111Wnt signaling pathway_Homo sapiens_hsa043100.50831063
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.50752748
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50295637
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49653604
115Insulin secretion_Homo sapiens_hsa049110.49478285
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.49026174
117Other glycan degradation_Homo sapiens_hsa005110.46809670
118Renal cell carcinoma_Homo sapiens_hsa052110.46279822
119Focal adhesion_Homo sapiens_hsa045100.45706512
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.45704039
121GnRH signaling pathway_Homo sapiens_hsa049120.43767848
122Lysosome_Homo sapiens_hsa041420.43612642
123Estrogen signaling pathway_Homo sapiens_hsa049150.43532298
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.43495988
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43490210
126Pancreatic cancer_Homo sapiens_hsa052120.42424464
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.42178700
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41802454
129Pathways in cancer_Homo sapiens_hsa052000.41771972
130TNF signaling pathway_Homo sapiens_hsa046680.40178375
131Inositol phosphate metabolism_Homo sapiens_hsa005620.39328253
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38497467
133Bile secretion_Homo sapiens_hsa049760.37634639
134Glucagon signaling pathway_Homo sapiens_hsa049220.35378594
135Viral carcinogenesis_Homo sapiens_hsa052030.34280295
136beta-Alanine metabolism_Homo sapiens_hsa004100.31624191

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