FAM83F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)7.07786964
2desmosome organization (GO:0002934)6.82703738
3hemidesmosome assembly (GO:0031581)6.55115104
4bundle of His cell to Purkinje myocyte communication (GO:0086069)5.56935307
5intestinal absorption (GO:0050892)5.09493796
6keratinization (GO:0031424)4.94490610
7regulation of water loss via skin (GO:0033561)4.84266393
8cellular ketone body metabolic process (GO:0046950)4.76462265
9establishment of skin barrier (GO:0061436)4.74294459
10behavioral response to nicotine (GO:0035095)4.52636534
11ketone body metabolic process (GO:1902224)4.26500642
12fucose catabolic process (GO:0019317)4.25829479
13L-fucose metabolic process (GO:0042354)4.25829479
14L-fucose catabolic process (GO:0042355)4.25829479
15sulfur amino acid catabolic process (GO:0000098)4.05359706
16exocrine pancreas development (GO:0031017)3.91288907
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.82479931
18response to pheromone (GO:0019236)3.81307960
19transcytosis (GO:0045056)3.76731141
20cysteine metabolic process (GO:0006534)3.74782773
21phospholipid efflux (GO:0033700)3.71264682
22protein retention in ER lumen (GO:0006621)3.70561284
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.70454089
24thyroid hormone metabolic process (GO:0042403)3.64960276
25tryptophan catabolic process (GO:0006569)3.64411644
26indole-containing compound catabolic process (GO:0042436)3.64411644
27indolalkylamine catabolic process (GO:0046218)3.64411644
28digestion (GO:0007586)3.62972106
29regulation of hippo signaling (GO:0035330)3.62393457
30water-soluble vitamin biosynthetic process (GO:0042364)3.62226272
31homocysteine metabolic process (GO:0050667)3.61579039
32intestinal epithelial cell development (GO:0060576)3.60589873
33indolalkylamine metabolic process (GO:0006586)3.56865013
34kidney morphogenesis (GO:0060993)3.52424513
35keratinocyte development (GO:0003334)3.47663409
36L-phenylalanine catabolic process (GO:0006559)3.47293183
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.47293183
38axoneme assembly (GO:0035082)3.44660096
39L-phenylalanine metabolic process (GO:0006558)3.44264067
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.44264067
41regulation of gene silencing by RNA (GO:0060966)3.43088032
42regulation of posttranscriptional gene silencing (GO:0060147)3.43088032
43regulation of gene silencing by miRNA (GO:0060964)3.43088032
44high-density lipoprotein particle remodeling (GO:0034375)3.40003083
45regulation of phospholipase A2 activity (GO:0032429)3.39679973
46regulation of cholesterol homeostasis (GO:2000188)3.37653013
47molting cycle (GO:0042303)3.37038686
48hair cycle (GO:0042633)3.37038686
49kynurenine metabolic process (GO:0070189)3.36828510
50negative regulation of cholesterol transport (GO:0032375)3.33951739
51negative regulation of sterol transport (GO:0032372)3.33951739
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29951173
53keratinocyte differentiation (GO:0030216)3.27954830
54phosphatidylinositol acyl-chain remodeling (GO:0036149)3.26500105
55reverse cholesterol transport (GO:0043691)3.26128127
56multicellular organismal water homeostasis (GO:0050891)3.24262599
57primary alcohol catabolic process (GO:0034310)3.21997609
58cellular modified amino acid catabolic process (GO:0042219)3.21258405
59signal peptide processing (GO:0006465)3.17545056
60negative regulation of translation, ncRNA-mediated (GO:0040033)3.10826402
61regulation of translation, ncRNA-mediated (GO:0045974)3.10826402
62negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.10826402
63tryptophan metabolic process (GO:0006568)3.10731100
64reflex (GO:0060004)3.09517612
65urea cycle (GO:0000050)3.08804139
66urea metabolic process (GO:0019627)3.08804139
67sulfation (GO:0051923)3.08128310
68plasma lipoprotein particle clearance (GO:0034381)3.05464793
69epithelial cell differentiation involved in prostate gland development (GO:0060742)3.04911756
70keratinocyte proliferation (GO:0043616)3.02712630
71thyroid hormone generation (GO:0006590)3.01508886
72cholesterol homeostasis (GO:0042632)3.01479594
73lipoprotein metabolic process (GO:0042157)2.99612648
74regulation of triglyceride catabolic process (GO:0010896)2.99295567
75low-density lipoprotein particle clearance (GO:0034383)2.98921219
76photoreceptor cell maintenance (GO:0045494)2.98794650
77sterol homeostasis (GO:0055092)2.97866565
78cholesterol transport (GO:0030301)2.97830529
79sterol transport (GO:0015918)2.97830529
80protein carboxylation (GO:0018214)2.97749583
81peptidyl-glutamic acid carboxylation (GO:0017187)2.97749583
82ethanol metabolic process (GO:0006067)2.97744887
83phosphatidylserine acyl-chain remodeling (GO:0036150)2.97010502
84positive regulation of lipoprotein lipase activity (GO:0051006)2.95324057
85positive regulation of triglyceride lipase activity (GO:0061365)2.95324057
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94386676
87adhesion of symbiont to host cell (GO:0044650)2.93594752
88virion attachment to host cell (GO:0019062)2.93594752
89water homeostasis (GO:0030104)2.93506555
90cilium or flagellum-dependent cell motility (GO:0001539)2.92806869
91adhesion of symbiont to host (GO:0044406)2.92467110
92plasma lipoprotein particle assembly (GO:0034377)2.92317089
93protein-lipid complex assembly (GO:0065005)2.92268362
94positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.92098819
95regulation of keratinocyte proliferation (GO:0010837)2.91663716
96detection of light stimulus involved in sensory perception (GO:0050962)2.90442167
97detection of light stimulus involved in visual perception (GO:0050908)2.90442167
98regulation of hexokinase activity (GO:1903299)2.90098895
99regulation of glucokinase activity (GO:0033131)2.90098895
100interferon-gamma secretion (GO:0072643)2.88825948
1013-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.87420848
102purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.87420848
103respiratory chain complex IV assembly (GO:0008535)2.86098189
104cholesterol efflux (GO:0033344)2.85899127
105alpha-linolenic acid metabolic process (GO:0036109)2.84769110
106skin morphogenesis (GO:0043589)2.83226792
107phospholipid homeostasis (GO:0055091)2.82623294
1084-hydroxyproline metabolic process (GO:0019471)2.82061159
109transepithelial transport (GO:0070633)2.80097500
110epithelial cilium movement (GO:0003351)2.79751583
111nitrogen cycle metabolic process (GO:0071941)2.79228187
112preassembly of GPI anchor in ER membrane (GO:0016254)2.77009201
113protein-lipid complex remodeling (GO:0034368)2.76691199
114macromolecular complex remodeling (GO:0034367)2.76691199
115plasma lipoprotein particle remodeling (GO:0034369)2.76691199
116negative regulation of keratinocyte proliferation (GO:0010839)2.76617815
117protein K11-linked deubiquitination (GO:0035871)2.73822333
118cilium movement (GO:0003341)2.73417036
119negative regulation of digestive system process (GO:0060457)2.72902334
120drug catabolic process (GO:0042737)2.72553307
121antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.70922142
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70922142
123antigen processing and presentation of endogenous antigen (GO:0019883)2.69893282
124regulation of cholesterol esterification (GO:0010872)2.69629911
125fibrinolysis (GO:0042730)2.69618969
126bile acid and bile salt transport (GO:0015721)2.69493165
127epidermal cell differentiation (GO:0009913)2.68569033
128UDP-N-acetylglucosamine metabolic process (GO:0006047)2.68228884
129peptide cross-linking (GO:0018149)2.68019919
130aromatic amino acid family catabolic process (GO:0009074)2.67584033
131phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.67336415
132intermediate filament organization (GO:0045109)2.65777446
133regulation of heart rate by cardiac conduction (GO:0086091)2.65429114
134multicellular organism reproduction (GO:0032504)2.65150311
135Golgi transport vesicle coating (GO:0048200)2.65006110
136COPI coating of Golgi vesicle (GO:0048205)2.65006110
137amino-acid betaine metabolic process (GO:0006577)2.64660417
138indole-containing compound metabolic process (GO:0042430)2.63907057
139regulation of cholesterol transport (GO:0032374)2.61445463
140regulation of sterol transport (GO:0032371)2.61445463
141regulation of mesoderm development (GO:2000380)2.61189324
142peptide catabolic process (GO:0043171)2.60788463
143organic cation transport (GO:0015695)2.60391863
144magnesium ion transport (GO:0015693)2.60040917
145triglyceride homeostasis (GO:0070328)2.58220069
146acylglycerol homeostasis (GO:0055090)2.58220069
147exogenous drug catabolic process (GO:0042738)2.58193658
148fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.56970603
149positive regulation of triglyceride metabolic process (GO:0090208)2.56811624
150positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56094892
151regulation of action potential (GO:0098900)2.55269727
152lysine catabolic process (GO:0006554)2.55095947
153lysine metabolic process (GO:0006553)2.55095947
154cytochrome complex assembly (GO:0017004)2.54713563
155cornea development in camera-type eye (GO:0061303)2.54460171
156positive regulation of fatty acid transport (GO:2000193)2.52575035
157protein localization to cilium (GO:0061512)2.52499037
158negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51435987
159auditory receptor cell differentiation (GO:0042491)2.50538725
160regulation of bile acid biosynthetic process (GO:0070857)2.49444066
161auditory receptor cell stereocilium organization (GO:0060088)2.48663250
162amine catabolic process (GO:0009310)2.48233148
163cellular biogenic amine catabolic process (GO:0042402)2.48233148
164angiotensin maturation (GO:0002003)2.47828261
165serine family amino acid biosynthetic process (GO:0009070)2.47686744
166polarized epithelial cell differentiation (GO:0030859)2.47354238
167hormone catabolic process (GO:0042447)2.45044217
168bile acid metabolic process (GO:0008206)2.44917863
169very-low-density lipoprotein particle assembly (GO:0034379)2.44882869
170cilium organization (GO:0044782)2.44713112
171proline transport (GO:0015824)2.43903944
172cell-substrate junction assembly (GO:0007044)2.42992071
173polyol catabolic process (GO:0046174)2.42367058
174NAD biosynthetic process (GO:0009435)2.42339387
175neural tube formation (GO:0001841)2.41444830
176axonemal dynein complex assembly (GO:0070286)2.41222050
177nephron epithelium morphogenesis (GO:0072088)2.40834626
178nephron tubule morphogenesis (GO:0072078)2.40834626
179phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.40554384
180somite rostral/caudal axis specification (GO:0032525)2.40059284
181protein-cofactor linkage (GO:0018065)2.38674120
182DNA deamination (GO:0045006)2.38249500
183fucosylation (GO:0036065)2.38140094
184positive regulation of sodium ion transmembrane transport (GO:1902307)2.38003933
185gamma-aminobutyric acid transport (GO:0015812)2.37385742
186retinol metabolic process (GO:0042572)2.36992587
187cilium assembly (GO:0042384)2.36943530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.76203939
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.06321299
3ZNF274_21170338_ChIP-Seq_K562_Hela3.70286176
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.60216196
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.58417196
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.38630887
7VDR_22108803_ChIP-Seq_LS180_Human3.21943559
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.08106014
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.99448191
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.70806473
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.42712836
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.41046152
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.37727791
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32840413
15GBX2_23144817_ChIP-Seq_PC3_Human2.23549304
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20012574
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19635715
18IGF1R_20145208_ChIP-Seq_DFB_Human2.19466360
19SOX2_27498859_Chip-Seq_STOMACH_Mouse2.17746329
20P63_26484246_Chip-Seq_KERATINOCYTES_Human2.14133916
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.08078482
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04755425
23* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01840583
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.01613086
25ZNF263_19887448_ChIP-Seq_K562_Human2.00881846
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.99641465
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.99521922
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99284051
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98968621
30* GATA4_25053715_ChIP-Seq_YYC3_Human1.97530677
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93454442
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.90347370
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89373860
34GATA6_25053715_ChIP-Seq_YYC3_Human1.88034586
35* FOXO3_23340844_ChIP-Seq_DLD1_Human1.86390272
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85709180
37CLOCK_20551151_ChIP-Seq_293T_Human1.82982930
38ER_23166858_ChIP-Seq_MCF-7_Human1.80332107
39RACK7_27058665_Chip-Seq_MCF-7_Human1.76369228
40P300_19829295_ChIP-Seq_ESCs_Human1.76188031
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75000543
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74541346
43BCAT_22108803_ChIP-Seq_LS180_Human1.69337875
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67437039
45SOX2_20726797_ChIP-Seq_SW620_Human1.65411128
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63121189
47FUS_26573619_Chip-Seq_HEK293_Human1.61285270
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59575331
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.58572501
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.58557233
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58329519
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57890862
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56230657
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.54647378
55TAF15_26573619_Chip-Seq_HEK293_Human1.54306479
56STAT3_23295773_ChIP-Seq_U87_Human1.53856139
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.53651250
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52192281
59TCF4_23295773_ChIP-Seq_U87_Human1.51851035
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.50812509
61AR_25329375_ChIP-Seq_VCAP_Human1.50507205
62CDX2_22108803_ChIP-Seq_LS180_Human1.50426600
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50072276
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.49903008
65EWS_26573619_Chip-Seq_HEK293_Human1.49433460
66ATF3_27146783_Chip-Seq_COLON_Human1.48094089
67CBP_20019798_ChIP-Seq_JUKART_Human1.46086206
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46086206
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45854989
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45854989
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44797087
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44729971
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.44694796
74TCF4_22108803_ChIP-Seq_LS180_Human1.43889970
75LXR_22292898_ChIP-Seq_THP-1_Human1.43445991
76* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42825748
77AHR_22903824_ChIP-Seq_MCF-7_Human1.41589711
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41115076
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40147881
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.40147881
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39966235
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39143354
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38694560
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38694560
85* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38691780
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.36866715
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36155903
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.36053158
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35135450
90IRF1_19129219_ChIP-ChIP_H3396_Human1.33899570
91HOXB7_26014856_ChIP-Seq_BT474_Human1.33717157
92* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33323760
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33074658
94AR_20517297_ChIP-Seq_VCAP_Human1.31602679
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.30094212
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29645781
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29470667
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29446423
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29039615
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26274510
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25052406
102AR_21572438_ChIP-Seq_LNCaP_Human1.24573294
103RUNX2_22187159_ChIP-Seq_PCA_Human1.24405323
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23397108
105GATA3_21878914_ChIP-Seq_MCF-7_Human1.23046883
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.22852533
107NANOG_19829295_ChIP-Seq_ESCs_Human1.21955743
108SOX2_19829295_ChIP-Seq_ESCs_Human1.21955743
109* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21951470
110RXR_22108803_ChIP-Seq_LS180_Human1.19614494
111NCOR_22424771_ChIP-Seq_293T_Human1.17912050
112EZH2_22144423_ChIP-Seq_EOC_Human1.17737212
113TP53_22573176_ChIP-Seq_HFKS_Human1.17190900
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15926962
115ELK3_25401928_ChIP-Seq_HUVEC_Human1.15831512
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14823650
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13708425
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13697094
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13371275
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12968174
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11799422
122KLF5_25053715_ChIP-Seq_YYC3_Human1.11747993
123FOXA1_25552417_ChIP-Seq_VCAP_Human1.11483681
124NFE2_27457419_Chip-Seq_LIVER_Mouse1.10781279
125GATA3_24758297_ChIP-Seq_MCF-7_Human1.09910722
126* TP63_23658742_ChIP-Seq_EP156T_Human1.09230410
127HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09178834
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08446244
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08321894
130* SMAD3_21741376_ChIP-Seq_HESCs_Human1.06700537
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05940936
132FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05935516
133NOTCH1_21737748_ChIP-Seq_TLL_Human1.05820160
134DROSHA_22980978_ChIP-Seq_HELA_Human1.05718572
135BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05683643
136* TP63_22573176_ChIP-Seq_HFKS_Human1.04966692
137THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04646358
138ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04639327
139REST_21632747_ChIP-Seq_MESCs_Mouse1.04607984
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.04376075
141FOXA2_19822575_ChIP-Seq_HepG2_Human1.04326304
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03760249
143GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.03282799
144ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03239849
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02135119
146EGR1_19032775_ChIP-ChIP_M12_Human1.01821439
147ETV1_20927104_ChIP-Seq_GIST48_Human1.01512775
148PHF8_20622853_ChIP-Seq_HELA_Human1.01193018
149TBL1_22424771_ChIP-Seq_293T_Human1.01070719
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99103944
151ERA_21632823_ChIP-Seq_H3396_Human0.98394515
152PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98022562
153CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97908921
154NFYB_21822215_ChIP-Seq_K562_Human0.97823496
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.96481761
156* MYC_19829295_ChIP-Seq_ESCs_Human0.96271595
157ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96001630
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.95721214
159ESR1_20079471_ChIP-ChIP_T-47D_Human0.94560168
160BCOR_27268052_Chip-Seq_Bcells_Human0.93701905
161TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93531314
162UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93415720
163* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93200290
164* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92970818
165* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91166294
166E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90991415
167ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90205140
168SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89492236
169* IRF8_27001747_Chip-Seq_BMDM_Mouse0.88033469
170FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87372286
171IRF8_21731497_ChIP-ChIP_J774_Mouse0.86792627
172SA1_27219007_Chip-Seq_ERYTHROID_Human0.86505783
173PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86101521
174FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85775161
175TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85426593
176TCF7_22412390_ChIP-Seq_EML_Mouse0.84328559
177JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84227418
178ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84061290
179* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82934860
180GATA2_19941826_ChIP-Seq_K562_Human0.82440413
181* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80649028
182CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79737094
183RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.79645121
184GATA2_21666600_ChIP-Seq_HMVEC_Human0.78775930
185JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78742181
186CREB1_26743006_Chip-Seq_LNCaP_Human0.77926348
187CJUN_26792858_Chip-Seq_BT549_Human0.77493771
188KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76922536
189IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.76619234
190HNF4A_19822575_ChIP-Seq_HepG2_Human0.75536365
191NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74624245

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.48905441
2MP0001666_abnormal_nutrient_absorption4.31382553
3MP0002796_impaired_skin_barrier4.19087431
4MP0002254_reproductive_system_inflammat3.89713924
5MP0005360_urolithiasis3.87916019
6MP0005365_abnormal_bile_salt3.42528996
7MP0003705_abnormal_hypodermis_morpholog3.41585326
8MP0005083_abnormal_biliary_tract3.39202441
9MP0002139_abnormal_hepatobiliary_system3.07935280
10MP0004043_abnormal_pH_regulation3.05919781
11MP0005275_abnormal_skin_tensile2.93068641
12MP0005085_abnormal_gallbladder_physiolo2.87793086
13MP0003195_calcinosis2.76714263
14MP0002876_abnormal_thyroid_physiology2.64945303
15MP0005501_abnormal_skin_physiology2.45066260
16MP0003191_abnormal_cellular_cholesterol2.42218522
17MP0000579_abnormal_nail_morphology2.35735325
18MP0004264_abnormal_extraembryonic_tissu2.35465190
19MP0002060_abnormal_skin_morphology2.31039819
20MP0010678_abnormal_skin_adnexa2.29626012
21MP0004885_abnormal_endolymph2.27706142
22MP0004147_increased_porphyrin_level2.23446299
23MP0009840_abnormal_foam_cell2.23212354
24MP0002098_abnormal_vibrissa_morphology2.14804837
25MP0003453_abnormal_keratinocyte_physiol2.13573724
26MP0004947_skin_inflammation2.13101577
27MP0008872_abnormal_physiological_respon2.12084985
28MP0000383_abnormal_hair_follicle2.11060390
29MP0001216_abnormal_epidermal_layer2.08196738
30MP0001485_abnormal_pinna_reflex2.05659971
31MP0005551_abnormal_eye_electrophysiolog2.05402342
32MP0008875_abnormal_xenobiotic_pharmacok1.91733603
33MP0003878_abnormal_ear_physiology1.85218815
34MP0005377_hearing/vestibular/ear_phenot1.85218815
35MP0008877_abnormal_DNA_methylation1.85149373
36MP0010329_abnormal_lipoprotein_level1.84258300
37MP0000566_synostosis1.83827975
38MP0001501_abnormal_sleep_pattern1.82144513
39MP0005645_abnormal_hypothalamus_physiol1.77652341
40MP0003566_abnormal_cell_adhesion1.73100527
41MP0003718_maternal_effect1.70456722
42MP0003941_abnormal_skin_development1.66753038
43MP0000377_abnormal_hair_follicle1.62209987
44MP0005220_abnormal_exocrine_pancreas1.61838172
45MP0001984_abnormal_olfaction1.60710490
46MP0004133_heterotaxia1.58647873
47MP0005646_abnormal_pituitary_gland1.58095593
48MP0005451_abnormal_body_composition1.57507602
49MP0010771_integument_phenotype1.57278151
50MP0001873_stomach_inflammation1.56513797
51MP0003300_gastrointestinal_ulcer1.51229605
52MP0000647_abnormal_sebaceous_gland1.50895018
53MP0004381_abnormal_hair_follicle1.50391682
54MP0003252_abnormal_bile_duct1.46819651
55MP0004019_abnormal_vitamin_homeostasis1.44973689
56MP0003868_abnormal_feces_composition1.43274504
57MP0003890_abnormal_embryonic-extraembry1.40748642
58MP0001849_ear_inflammation1.38993530
59MP0010352_gastrointestinal_tract_polyps1.38897319
60MP0000467_abnormal_esophagus_morphology1.38831659
61MP0006072_abnormal_retinal_apoptosis1.35214624
62MP0001968_abnormal_touch/_nociception1.34847364
63MP0003646_muscle_fatigue1.34568682
64MP0000569_abnormal_digit_pigmentation1.33844514
65MP0002653_abnormal_ependyma_morphology1.32044957
66MP0001765_abnormal_ion_homeostasis1.28654691
67MP0010386_abnormal_urinary_bladder1.25735001
68MP0000427_abnormal_hair_cycle1.25247934
69MP0005174_abnormal_tail_pigmentation1.24754966
70MP0005058_abnormal_lysosome_morphology1.24297787
71MP0009780_abnormal_chondrocyte_physiolo1.22489368
72MP0002909_abnormal_adrenal_gland1.21640186
73MP0002837_dystrophic_cardiac_calcinosis1.20152218
74MP0004185_abnormal_adipocyte_glucose1.19067029
75MP0000609_abnormal_liver_physiology1.18882880
76MP0005636_abnormal_mineral_homeostasis1.18467158
77MP0005410_abnormal_fertilization1.18442095
78MP0005253_abnormal_eye_physiology1.18372688
79MP0002938_white_spotting1.16966173
80MP0002118_abnormal_lipid_homeostasis1.14644611
81MP0003806_abnormal_nucleotide_metabolis1.14399309
82MP0002638_abnormal_pupillary_reflex1.13157115
83MP0001188_hyperpigmentation1.13051422
84MP0000631_abnormal_neuroendocrine_gland1.11632148
85MP0010155_abnormal_intestine_physiology1.10586494
86MP0009931_abnormal_skin_appearance1.10475051
87MP0009745_abnormal_behavioral_response1.09092147
88MP0009046_muscle_twitch1.08980789
89MP0002736_abnormal_nociception_after1.08462165
90MP0009643_abnormal_urine_homeostasis1.06735252
91MP0000462_abnormal_digestive_system1.05175445
92MP0003787_abnormal_imprinting1.04938874
93MP0001243_abnormal_dermal_layer1.04509149
94MP0005023_abnormal_wound_healing1.03834913
95MP0005332_abnormal_amino_acid1.03474067
96MP0002095_abnormal_skin_pigmentation1.02335422
97MP0000230_abnormal_systemic_arterial1.00043539
98MP0005670_abnormal_white_adipose0.98249208
99MP0001944_abnormal_pancreas_morphology0.97242086
100MP0001986_abnormal_taste_sensitivity0.97207930
101MP0001851_eye_inflammation0.94788366
102MP0005075_abnormal_melanosome_morpholog0.94736526
103MP0005395_other_phenotype0.93285265
104MP0003283_abnormal_digestive_organ0.93240671
105MP0002557_abnormal_social/conspecific_i0.93085982
106MP0002822_catalepsy0.93025498
107MP0006054_spinal_hemorrhage0.91669608
108MP0005448_abnormal_energy_balance0.91353630
109MP0000367_abnormal_coat/_hair0.90899439
110MP0008961_abnormal_basal_metabolism0.90696375
111MP0001191_abnormal_skin_condition0.90437860
112MP0005367_renal/urinary_system_phenotyp0.89612477
113MP0000516_abnormal_urinary_system0.89612477
114MP0003119_abnormal_digestive_system0.89194132
115MP0002693_abnormal_pancreas_physiology0.88804865
116MP0008995_early_reproductive_senescence0.88792214
117MP0002102_abnormal_ear_morphology0.88657153
118MP0004742_abnormal_vestibular_system0.88457037
119MP0000537_abnormal_urethra_morphology0.87704872
120MP0003436_decreased_susceptibility_to0.85760139
121MP0001346_abnormal_lacrimal_gland0.85548707
122MP0003953_abnormal_hormone_level0.83785893
123MP0000538_abnormal_urinary_bladder0.83708729
124MP0004142_abnormal_muscle_tone0.82295437
125MP0004272_abnormal_basement_membrane0.81478562
126MP0005379_endocrine/exocrine_gland_phen0.80897130
127MP0000604_amyloidosis0.79358638
128MP0000762_abnormal_tongue_morphology0.79313388
129MP0003866_abnormal_defecation0.78350521
130MP0002166_altered_tumor_susceptibility0.77186764
131MP0005381_digestive/alimentary_phenotyp0.76683039
132MP0003638_abnormal_response/metabolism_0.76444018
133MP0002138_abnormal_hepatobiliary_system0.76321423
134MP0000490_abnormal_crypts_of0.76024897
135MP0009384_cardiac_valve_regurgitation0.75851063
136MP0005310_abnormal_salivary_gland0.74163457
137MP0000685_abnormal_immune_system0.72893301
138MP0000477_abnormal_intestine_morphology0.72874603
139MP0003303_peritoneal_inflammation0.72860716
140MP0001663_abnormal_digestive_system0.71896328
141MP0005319_abnormal_enzyme/_coenzyme0.71713540
142MP0001756_abnormal_urination0.69989248
143MP0001845_abnormal_inflammatory_respons0.69416331
144MP0001664_abnormal_digestion0.69180321
145MP0005076_abnormal_cell_differentiation0.69109248
146MP0000627_abnormal_mammary_gland0.68445664
147MP0000613_abnormal_salivary_gland0.67756280
148MP0000470_abnormal_stomach_morphology0.67427403
149MP0002136_abnormal_kidney_physiology0.65349301
150MP0008438_abnormal_cutaneous_collagen0.64371781
151MP0005464_abnormal_platelet_physiology0.62880714
152MP0003011_delayed_dark_adaptation0.61298706
153MP0005084_abnormal_gallbladder_morpholo0.61147626
154MP0003183_abnormal_peptide_metabolism0.60670606
155MP0004782_abnormal_surfactant_physiolog0.59812086
156MP0002234_abnormal_pharynx_morphology0.59749258
157MP0000465_gastrointestinal_hemorrhage0.58763194
158MP0009053_abnormal_anal_canal0.58243680
159MP0008469_abnormal_protein_level0.58046238
160MP0001881_abnormal_mammary_gland0.57704148
161MP0006082_CNS_inflammation0.56530136
162MP0000598_abnormal_liver_morphology0.54887156
163MP0003045_fibrosis0.52836608

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.78167220
2Milia (HP:0001056)5.15101002
3Plantar hyperkeratosis (HP:0007556)4.83165964
4Pili torti (HP:0003777)4.82345911
5Onycholysis (HP:0001806)4.68320890
6Fragile nails (HP:0001808)4.27333938
7Woolly hair (HP:0002224)4.19506244
8Increased IgE level (HP:0003212)4.10488721
9Palmoplantar hyperkeratosis (HP:0000972)3.84906585
10Atrophic scars (HP:0001075)3.76082656
11Hypotrichosis (HP:0001006)3.74411615
12Abnormal hair laboratory examination (HP:0003328)3.70246546
13Palmar hyperkeratosis (HP:0010765)3.68038703
14Pancreatic cysts (HP:0001737)3.63838403
15Congenital stationary night blindness (HP:0007642)3.55199425
16Intrahepatic cholestasis (HP:0001406)3.51390198
17Fat malabsorption (HP:0002630)3.50012023
18Xanthomatosis (HP:0000991)3.44104224
19Abnormality of the renal cortex (HP:0011035)3.25859213
20Decreased circulating renin level (HP:0003351)3.23192831
21Deep venous thrombosis (HP:0002625)3.21010615
22Pancreatic fibrosis (HP:0100732)3.19774077
23Alopecia of scalp (HP:0002293)3.19088074
24True hermaphroditism (HP:0010459)3.14128071
25Molar tooth sign on MRI (HP:0002419)3.10603146
26Abnormality of midbrain morphology (HP:0002418)3.10603146
27Abnormality of monocarboxylic acid metabolism (HP:0010996)3.08240179
28Thick nail (HP:0001805)3.06350828
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.03213717
30Steatorrhea (HP:0002570)3.02708884
31Nephronophthisis (HP:0000090)3.02563070
32Nail dystrophy (HP:0008404)3.02009204
33Gaze-evoked nystagmus (HP:0000640)2.98884311
34Conjunctival hamartoma (HP:0100780)2.97701349
35Hypobetalipoproteinemia (HP:0003563)2.95363985
36Abnormality of the renal medulla (HP:0100957)2.91510301
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89511377
38Abnormality of nail color (HP:0100643)2.79998423
39Malnutrition (HP:0004395)2.79495580
40Vacuolated lymphocytes (HP:0001922)2.77491325
41Myocardial infarction (HP:0001658)2.74828821
42Abnormality of the axillary hair (HP:0100134)2.74174063
43Abnormality of secondary sexual hair (HP:0009888)2.74174063
44Congenital ichthyosiform erythroderma (HP:0007431)2.74055675
45Furrowed tongue (HP:0000221)2.73771242
46Chronic hepatic failure (HP:0100626)2.73605867
47Genetic anticipation (HP:0003743)2.70908360
48Abnormal blistering of the skin (HP:0008066)2.69923638
49Attenuation of retinal blood vessels (HP:0007843)2.62690459
50Fragile skin (HP:0001030)2.59159860
51Amelogenesis imperfecta (HP:0000705)2.51625227
52Cystic liver disease (HP:0006706)2.50618508
53Erythroderma (HP:0001019)2.50017108
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.49600288
55Hypoplastic labia majora (HP:0000059)2.49594321
56Progressive cerebellar ataxia (HP:0002073)2.47070346
57Hypothermia (HP:0002045)2.47031546
58Hyperventilation (HP:0002883)2.47011295
59Hypolipoproteinemia (HP:0010981)2.46719046
60Abnormality of renin-angiotensin system (HP:0000847)2.45974979
61Tubular atrophy (HP:0000092)2.42883617
62Lip pit (HP:0100267)2.41748706
63Congenital sensorineural hearing impairment (HP:0008527)2.41739113
64Abolished electroretinogram (ERG) (HP:0000550)2.41271890
65Type II lissencephaly (HP:0007260)2.40673432
66Ileus (HP:0002595)2.40321552
67Esophageal varix (HP:0002040)2.39292922
68Duplicated collecting system (HP:0000081)2.38427675
69Large for gestational age (HP:0001520)2.36715225
70Conjugated hyperbilirubinemia (HP:0002908)2.34088630
71Chronic bronchitis (HP:0004469)2.31928006
72Congenital, generalized hypertrichosis (HP:0004540)2.31842914
73Increased CSF protein (HP:0002922)2.30164347
74Hydroxyprolinuria (HP:0003080)2.28909369
75Abnormality of proline metabolism (HP:0010907)2.28909369
76Hyperactive renin-angiotensin system (HP:0000841)2.27170545
77Medial flaring of the eyebrow (HP:0010747)2.26641700
78Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26609969
79Pustule (HP:0200039)2.26401506
80Abnormality of the renal collecting system (HP:0004742)2.25972561
81Hypercholesterolemia (HP:0003124)2.25801934
82Abnormality of vitamin B metabolism (HP:0004340)2.24365055
83Abnormality of the labia majora (HP:0012881)2.23065082
84Ulnar claw (HP:0001178)2.22824760
85Abdominal distention (HP:0003270)2.21573873
86Renal cortical cysts (HP:0000803)2.21438561
87Increased cerebral lipofuscin (HP:0011813)2.20844891
88Epidermoid cyst (HP:0200040)2.20417487
89Hypoalphalipoproteinemia (HP:0003233)2.20148568
90Hyperglycinuria (HP:0003108)2.20125611
91Polydipsia (HP:0001959)2.18377437
92Abnormal drinking behavior (HP:0030082)2.18377437
93Axonal loss (HP:0003447)2.17102485
94Pendular nystagmus (HP:0012043)2.16570546
95Methylmalonic acidemia (HP:0002912)2.15822582
96Curly hair (HP:0002212)2.13861862
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13639246
98Abnormality of alanine metabolism (HP:0010916)2.13639246
99Hyperalaninemia (HP:0003348)2.13639246
100Hyperlipoproteinemia (HP:0010980)2.12909482
101Abnormal rod and cone electroretinograms (HP:0008323)2.12661418
102Abnormality of the nasal septum (HP:0000419)2.12234755
103Abnormality of the gastric mucosa (HP:0004295)2.10997567
104Abnormality of the common coagulation pathway (HP:0010990)2.10615279
105Amyloidosis (HP:0011034)2.09795715
106Abnormality of the intrinsic pathway (HP:0010989)2.09499948
107Erythema (HP:0010783)2.08106065
108Hyperammonemia (HP:0001987)2.07838345
109Decreased central vision (HP:0007663)2.07731236
110Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07587144
111Fair hair (HP:0002286)2.06850097
112Dehydration (HP:0001944)2.06497496
113Abnormality of chloride homeostasis (HP:0011422)2.04116220
114Widely spaced teeth (HP:0000687)2.03156265
115Complement deficiency (HP:0004431)2.02957088
116Type I diabetes mellitus (HP:0100651)2.02440740
117Peripheral demyelination (HP:0011096)2.01414833
118Ketosis (HP:0001946)2.01399863
119Absent/shortened dynein arms (HP:0200106)2.01347412
120Dynein arm defect of respiratory motile cilia (HP:0012255)2.01347412
121Hyperkalemia (HP:0002153)2.00857960
122Methylmalonic aciduria (HP:0012120)2.00616244
123Ketoacidosis (HP:0001993)2.00226906
124Abnormality of the pons (HP:0007361)1.99124606
125Clumsiness (HP:0002312)1.98390086
126Segmental peripheral demyelination/remyelination (HP:0003481)1.97962501
127Abnormal respiratory epithelium morphology (HP:0012253)1.97386147
128Abnormal respiratory motile cilium morphology (HP:0005938)1.97386147
129Labial hypoplasia (HP:0000066)1.96816098
130Ventricular tachycardia (HP:0004756)1.96483303
131Hypoplasia of the uterus (HP:0000013)1.96316976
132Hyperaldosteronism (HP:0000859)1.95064840
133Flat acetabular roof (HP:0003180)1.93369547
134Abnormality of serine family amino acid metabolism (HP:0010894)1.92916952
135Abnormality of glycine metabolism (HP:0010895)1.92916952
136Ectropion (HP:0000656)1.92337805
137Concave nail (HP:0001598)1.91958738
138Corneal erosion (HP:0200020)1.91919662
139Inability to walk (HP:0002540)1.91864118
140Hypoplasia of dental enamel (HP:0006297)1.91753785
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91574938
142Depressed nasal tip (HP:0000437)1.90829960
143Progressive inability to walk (HP:0002505)1.90819227
144Aplasia/hypoplasia of the uterus (HP:0008684)1.89304128
145Myopathic facies (HP:0002058)1.88424413
146Gangrene (HP:0100758)1.88105730
147Hypoplasia of the pons (HP:0012110)1.87080852
148Cerebellar dysplasia (HP:0007033)1.85985784
149Periodontitis (HP:0000704)1.85234773
150Vascular calcification (HP:0004934)1.84869777
151Pancreatitis (HP:0001733)1.84722408
152Abnormality of the vitamin B12 metabolism (HP:0004341)1.84707522
153Chorioretinal atrophy (HP:0000533)1.83833113
154Abnormal ciliary motility (HP:0012262)1.83085963
155Eczematoid dermatitis (HP:0000976)1.82009497
156Sclerocornea (HP:0000647)1.81940219
157Abnormality of the Achilles tendon (HP:0005109)1.81797545
158Bony spicule pigmentary retinopathy (HP:0007737)1.81359842
159Mucopolysacchariduria (HP:0008155)1.80916882
160Urinary glycosaminoglycan excretion (HP:0003541)1.80916882
161Protruding tongue (HP:0010808)1.80580911
162Abnormality of macular pigmentation (HP:0008002)1.80528829
163Increased connective tissue (HP:0009025)1.80026051
164Parakeratosis (HP:0001036)1.79655484
165Male pseudohermaphroditism (HP:0000037)1.79218187
166Abnormality of complement system (HP:0005339)1.78985740
167Abnormality of purine metabolism (HP:0004352)1.78469562
168Hyporeflexia of lower limbs (HP:0002600)1.78213616
169Abnormality of vitamin metabolism (HP:0100508)1.76726121
170Systemic lupus erythematosus (HP:0002725)1.75259758
171Congenital hepatic fibrosis (HP:0002612)1.74692255
172Lissencephaly (HP:0001339)1.74589206
173Acanthosis nigricans (HP:0000956)1.73957934
174Polyuria (HP:0000103)1.73718286
175Hamartoma of the eye (HP:0010568)1.73583772
176Pruritus (HP:0000989)1.72859041
177Hypoalbuminemia (HP:0003073)1.72852092
178Spastic diplegia (HP:0001264)1.71919843
179Sparse eyelashes (HP:0000653)1.71683330
180Prolonged partial thromboplastin time (HP:0003645)1.71222401
181Aplasia cutis congenita (HP:0001057)1.69634593
182Late onset (HP:0003584)1.68414091
183Gout (HP:0001997)1.67681787
184Dysostosis multiplex (HP:0000943)1.67487482

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.65508654
2MST1R3.72028137
3BCKDK3.19096672
4TRIB33.03440710
5MST42.95721013
6INSRR2.92377708
7ACVR1B2.80702240
8MAP2K22.58328129
9MAP4K22.56057332
10PTK62.55203579
11BMPR1B2.54093243
12PKN22.53968642
13EPHA22.46858386
14FRK2.46134390
15MAPKAPK32.44399805
16ADRBK22.44268539
17MAP3K32.43235917
18LATS12.41568393
19WNK32.37157689
20OXSR12.33508377
21ZAK2.33334131
22RIPK12.32131213
23AKT32.30055805
24WNK42.23836103
25EPHB12.11813744
26FGFR41.89630227
27MAP3K21.87209474
28LRRK21.76402412
29FER1.71890259
30RPS6KB21.69443592
31EEF2K1.69386727
32MAP3K111.66527834
33STK101.63216574
34SIK11.58249445
35FGFR21.58050798
36PIK3CG1.51640290
37MET1.51148422
38PINK11.48259130
39CASK1.47629552
40TLK11.46930567
41STK38L1.46922182
42TYK21.43365587
43TBK11.40479392
44TGFBR11.34760324
45TAF11.31928923
46PTK21.18437180
47GRK61.17440487
48MKNK21.16610168
49DAPK21.14753912
50MAP4K11.13116102
51MAP3K101.13007071
52TAOK31.12915935
53PAK31.11143025
54TTN1.09735060
55MAP3K41.06721554
56PRKCE1.05589649
57MAP2K11.02529392
58MAP3K141.02509525
59MAP2K31.02239814
60EPHA31.01179796
61DYRK1B0.98889592
62ADRBK10.98374968
63MAPK130.97010914
64CAMK1G0.96913843
65TNK20.95699038
66TAOK10.95168008
67MAP3K10.93608429
68MAP2K60.93081468
69NLK0.93016544
70BRSK20.92369934
71STK240.87361235
72MAP3K80.84677229
73CDK60.79442272
74SCYL20.77670505
75PAK40.76620193
76LMTK20.76276944
77BMX0.75807683
78MAPK150.75056101
79DDR20.74166747
80NME20.74107794
81PRKCI0.73895089
82CSK0.72459577
83ERBB20.72104028
84TXK0.71385432
85EPHB20.70778356
86IKBKE0.70113737
87TESK10.68720607
88PAK20.68395155
89PNCK0.67687669
90ZAP700.66661791
91PRKG20.66611851
92MAP3K70.65180452
93EIF2AK30.65025996
94PRKAA10.64884792
95IKBKB0.63920786
96MAPKAPK50.63346460
97TRIM280.62960591
98NME10.61691036
99NUAK10.61343873
100MATK0.60765242
101TRPM70.60678959
102PHKG10.59212015
103PHKG20.59212015
104PTK2B0.59092797
105FGFR30.59068751
106JAK20.57260574
107MAPK110.57178418
108PRKCG0.56398864
109STK30.56215284
110STK110.55919734
111TNIK0.54204099
112ERBB40.53420636
113CSNK1G10.52467878
114NTRK30.52256430
115JAK10.50536979
116MTOR0.50527183
117PDGFRB0.50398078
118KIT0.50187438
119RET0.49681483
120SGK20.48518654
121FLT30.47319188
122ITK0.47166578
123PLK20.46814174
124TAOK20.46364640
125BCR0.46298410
126CSNK1A10.45547606
127MAPKAPK20.44830662
128GSK3A0.44781446
129PIM20.44683818
130CSNK1A1L0.43374188
131PRKD30.43279787
132RPS6KA50.42887522
133TGFBR20.42506458
134KSR20.42136976
135CDK120.41961180
136SGK4940.41871863
137SGK2230.41871863
138PRKAA20.40032867
139FGFR10.39522365
140PIK3CA0.38487087
141DYRK20.36700309
142HIPK20.36669008
143CSNK1G20.35706300
144RPS6KA10.35693125
145IRAK10.35614461
146STK390.35586758
147CAMKK20.35509928
148CAMK1D0.35447267
149EGFR0.34856982
150CHUK0.34810427
151IRAK30.34442103
152JAK30.34142406
153GRK10.34131411
154MUSK0.33841495
155PRKCZ0.33592210
156BTK0.33368063
157CSNK1G30.33320963
158BLK0.31881548
159PRKCQ0.31441176
160RPS6KA40.31418821
161CDK90.29848852
162WNK10.29724263
163ABL10.29384440
164PRKCA0.29164762
165MAP2K70.28440757
166PRKACA0.27459257
167PRKD20.24249274

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.07081313
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.60719548
3Phototransduction_Homo sapiens_hsa047442.53636336
4Histidine metabolism_Homo sapiens_hsa003402.36675688
5Sulfur metabolism_Homo sapiens_hsa009202.36461984
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.26101155
7Pancreatic secretion_Homo sapiens_hsa049722.21597806
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.17310418
9Protein digestion and absorption_Homo sapiens_hsa049742.16162336
10Caffeine metabolism_Homo sapiens_hsa002322.13069595
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11203719
12Nitrogen metabolism_Homo sapiens_hsa009101.96161312
13Arginine biosynthesis_Homo sapiens_hsa002201.92020217
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91992427
15Fatty acid degradation_Homo sapiens_hsa000711.85301690
16Folate biosynthesis_Homo sapiens_hsa007901.83688828
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78614480
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77303660
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.73778654
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72404528
21Tryptophan metabolism_Homo sapiens_hsa003801.71150484
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71130160
23Vitamin digestion and absorption_Homo sapiens_hsa049771.69778744
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64056669
25Glycerolipid metabolism_Homo sapiens_hsa005611.62900162
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62544216
27Steroid biosynthesis_Homo sapiens_hsa001001.57008843
28PPAR signaling pathway_Homo sapiens_hsa033201.56206652
29Linoleic acid metabolism_Homo sapiens_hsa005911.47960103
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47135517
31Complement and coagulation cascades_Homo sapiens_hsa046101.45331985
32Staphylococcus aureus infection_Homo sapiens_hsa051501.42851608
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40516174
34beta-Alanine metabolism_Homo sapiens_hsa004101.39644561
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35611409
36Renin-angiotensin system_Homo sapiens_hsa046141.30557607
37Chemical carcinogenesis_Homo sapiens_hsa052041.27591086
38Bile secretion_Homo sapiens_hsa049761.27294915
39Taste transduction_Homo sapiens_hsa047421.27064201
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25678725
41Protein export_Homo sapiens_hsa030601.23683660
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19735415
43Starch and sucrose metabolism_Homo sapiens_hsa005001.17197230
44Phenylalanine metabolism_Homo sapiens_hsa003601.16500761
45Mineral absorption_Homo sapiens_hsa049781.14160017
46Regulation of autophagy_Homo sapiens_hsa041401.07290131
47Circadian rhythm_Homo sapiens_hsa047101.07227652
48Nicotine addiction_Homo sapiens_hsa050331.06827540
49Arginine and proline metabolism_Homo sapiens_hsa003301.05230856
50RNA polymerase_Homo sapiens_hsa030201.03963145
51Sulfur relay system_Homo sapiens_hsa041221.03711017
52Propanoate metabolism_Homo sapiens_hsa006401.00410091
53Peroxisome_Homo sapiens_hsa041460.98707349
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96734229
55Retinol metabolism_Homo sapiens_hsa008300.96041027
56Homologous recombination_Homo sapiens_hsa034400.95509961
57Insulin secretion_Homo sapiens_hsa049110.93436887
58Fatty acid metabolism_Homo sapiens_hsa012120.92461534
59Basal transcription factors_Homo sapiens_hsa030220.91530511
60Serotonergic synapse_Homo sapiens_hsa047260.90319432
61ABC transporters_Homo sapiens_hsa020100.88759205
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88220426
63Ovarian steroidogenesis_Homo sapiens_hsa049130.87105042
64Oxidative phosphorylation_Homo sapiens_hsa001900.86769090
65Glutathione metabolism_Homo sapiens_hsa004800.86767338
66Galactose metabolism_Homo sapiens_hsa000520.85512894
67Lysosome_Homo sapiens_hsa041420.85086001
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83894887
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83779787
70Butanoate metabolism_Homo sapiens_hsa006500.83508177
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83468753
72Olfactory transduction_Homo sapiens_hsa047400.82860622
73Selenocompound metabolism_Homo sapiens_hsa004500.82631981
74Other glycan degradation_Homo sapiens_hsa005110.82398896
75Vitamin B6 metabolism_Homo sapiens_hsa007500.82228519
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80657794
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.79867062
78Collecting duct acid secretion_Homo sapiens_hsa049660.79510691
79Fanconi anemia pathway_Homo sapiens_hsa034600.78010947
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74812679
81One carbon pool by folate_Homo sapiens_hsa006700.74283371
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71808509
83Fructose and mannose metabolism_Homo sapiens_hsa000510.70664530
84Fatty acid elongation_Homo sapiens_hsa000620.70591378
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.69715978
86Bladder cancer_Homo sapiens_hsa052190.69563291
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68058713
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67818403
89Metabolic pathways_Homo sapiens_hsa011000.67343769
90Pyruvate metabolism_Homo sapiens_hsa006200.67044868
91Hepatitis C_Homo sapiens_hsa051600.66714818
92Toxoplasmosis_Homo sapiens_hsa051450.66188309
93Tyrosine metabolism_Homo sapiens_hsa003500.65654575
94Biosynthesis of amino acids_Homo sapiens_hsa012300.63900432
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62402823
96Arachidonic acid metabolism_Homo sapiens_hsa005900.62246143
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.61782273
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.61111501
99ECM-receptor interaction_Homo sapiens_hsa045120.60324000
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59967877
101Sphingolipid metabolism_Homo sapiens_hsa006000.59174156
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.57588259
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56106051
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54412073
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.53901512
106Glutamatergic synapse_Homo sapiens_hsa047240.53800668
107Amoebiasis_Homo sapiens_hsa051460.53367590
108Salivary secretion_Homo sapiens_hsa049700.53302457
109Carbon metabolism_Homo sapiens_hsa012000.51715202
110Dorso-ventral axis formation_Homo sapiens_hsa043200.49581749
111Ether lipid metabolism_Homo sapiens_hsa005650.48517780
112Lysine degradation_Homo sapiens_hsa003100.48497100
113Adherens junction_Homo sapiens_hsa045200.48468065
114Influenza A_Homo sapiens_hsa051640.47467961
115Small cell lung cancer_Homo sapiens_hsa052220.46941551
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.46819359
117Tight junction_Homo sapiens_hsa045300.46530504
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46420443
119Circadian entrainment_Homo sapiens_hsa047130.46135515
120Antigen processing and presentation_Homo sapiens_hsa046120.45763436
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45374621
122Insulin resistance_Homo sapiens_hsa049310.45366450
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41701774
124Pentose phosphate pathway_Homo sapiens_hsa000300.41555659
125Calcium signaling pathway_Homo sapiens_hsa040200.41207488
126RNA degradation_Homo sapiens_hsa030180.40809252
127GABAergic synapse_Homo sapiens_hsa047270.39341635
128Purine metabolism_Homo sapiens_hsa002300.39232667
129Morphine addiction_Homo sapiens_hsa050320.38212923
130Fatty acid biosynthesis_Homo sapiens_hsa000610.37674959
131VEGF signaling pathway_Homo sapiens_hsa043700.37653207
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37183484
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36965209
134Proteoglycans in cancer_Homo sapiens_hsa052050.36670157
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35192392
136Huntingtons disease_Homo sapiens_hsa050160.34245946
137Notch signaling pathway_Homo sapiens_hsa043300.34090262
138Legionellosis_Homo sapiens_hsa051340.33729579
139Apoptosis_Homo sapiens_hsa042100.32903343
140Pertussis_Homo sapiens_hsa051330.31645817
141Renin secretion_Homo sapiens_hsa049240.30647880

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