FAM72D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)6.55032146
2mitotic sister chromatid segregation (GO:0000070)6.35184708
3sister chromatid segregation (GO:0000819)6.11452635
4nuclear pore complex assembly (GO:0051292)6.02889337
5protein localization to chromosome, centromeric region (GO:0071459)5.92672013
6mitotic metaphase plate congression (GO:0007080)5.81979909
7protein localization to kinetochore (GO:0034501)5.77874508
8DNA unwinding involved in DNA replication (GO:0006268)5.71428562
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.46806709
10nuclear pore organization (GO:0006999)5.36930144
11metaphase plate congression (GO:0051310)5.10544320
12DNA topological change (GO:0006265)5.05324014
13regulation of mitotic spindle organization (GO:0060236)4.88210006
14kinetochore organization (GO:0051383)4.78832112
15regulation of spindle organization (GO:0090224)4.78159607
16DNA strand elongation involved in DNA replication (GO:0006271)4.68042768
17DNA strand elongation (GO:0022616)4.55570784
18pore complex assembly (GO:0046931)4.50868288
19mitotic nuclear envelope disassembly (GO:0007077)4.48314740
20establishment of chromosome localization (GO:0051303)4.48128474
21mitotic sister chromatid cohesion (GO:0007064)4.42176708
22positive regulation of chromosome segregation (GO:0051984)4.32864457
23regulation of chromosome segregation (GO:0051983)4.32614335
24chromosome condensation (GO:0030261)4.32076221
25CENP-A containing nucleosome assembly (GO:0034080)4.31377219
26telomere maintenance via semi-conservative replication (GO:0032201)4.30280803
27negative regulation of chromosome segregation (GO:0051985)4.21331254
28membrane disassembly (GO:0030397)4.20464406
29nuclear envelope disassembly (GO:0051081)4.20464406
30spindle checkpoint (GO:0031577)4.17127297
31DNA replication checkpoint (GO:0000076)4.10824519
32DNA ligation (GO:0006266)4.10449790
33establishment of integrated proviral latency (GO:0075713)4.10124703
34negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.09423721
35negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.09423721
36negative regulation of mitotic sister chromatid segregation (GO:0033048)4.09423721
37negative regulation of mitotic sister chromatid separation (GO:2000816)4.09423721
38negative regulation of sister chromatid segregation (GO:0033046)4.09423721
39chromatin remodeling at centromere (GO:0031055)4.07966404
40mitotic spindle checkpoint (GO:0071174)4.07517073
41chromosome segregation (GO:0007059)4.07299797
42mitotic spindle assembly checkpoint (GO:0007094)4.02609670
43meiotic chromosome segregation (GO:0045132)4.02434020
44protein localization to chromosome (GO:0034502)3.99933388
45regulation of mitotic metaphase/anaphase transition (GO:0030071)3.98344082
46regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.98344082
47spindle assembly checkpoint (GO:0071173)3.96580721
48DNA replication initiation (GO:0006270)3.93915791
49regulation of sister chromatid segregation (GO:0033045)3.93689561
50regulation of mitotic sister chromatid separation (GO:0010965)3.93689561
51regulation of mitotic sister chromatid segregation (GO:0033047)3.93689561
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.93530945
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.93530945
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.93530945
55kinetochore assembly (GO:0051382)3.92071572
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.84281951
57mitotic recombination (GO:0006312)3.82547185
58formation of translation preinitiation complex (GO:0001731)3.81056772
59regulation of translational fidelity (GO:0006450)3.79750526
60DNA packaging (GO:0006323)3.78991517
61telomere maintenance via recombination (GO:0000722)3.75810186
62DNA replication-independent nucleosome assembly (GO:0006336)3.65800342
63DNA replication-independent nucleosome organization (GO:0034724)3.65800342
64histone exchange (GO:0043486)3.47378242
65attachment of spindle microtubules to kinetochore (GO:0008608)3.46953883
66regulation of centriole replication (GO:0046599)3.46670940
67regulation of sister chromatid cohesion (GO:0007063)3.45382714
68regulation of centrosome cycle (GO:0046605)3.45143623
69DNA conformation change (GO:0071103)3.39494801
70DNA synthesis involved in DNA repair (GO:0000731)3.38597855
71folic acid-containing compound biosynthetic process (GO:0009396)3.33920461
72microtubule depolymerization (GO:0007019)3.31148911
73nuclear envelope organization (GO:0006998)3.28697856
74DNA duplex unwinding (GO:0032508)3.24350830
75regulation of RNA export from nucleus (GO:0046831)3.22911340
76negative regulation of mitosis (GO:0045839)3.22359503
77regulation of DNA endoreduplication (GO:0032875)3.17655568
78IMP biosynthetic process (GO:0006188)3.16341403
79DNA geometric change (GO:0032392)3.14591979
80ATP-dependent chromatin remodeling (GO:0043044)3.14038902
81chromatin assembly or disassembly (GO:0006333)3.13274131
82purine nucleobase biosynthetic process (GO:0009113)3.12450947
83protein complex localization (GO:0031503)3.09724723
84establishment of viral latency (GO:0019043)3.09626599
85mitotic G2/M transition checkpoint (GO:0044818)3.09038711
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.08174962
87mitotic cell cycle (GO:0000278)3.07473072
88telomere maintenance via telomere lengthening (GO:0010833)3.01602991
89negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.00064655
90negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99292310
91chromosome organization (GO:0051276)2.97451617
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97212873
93resolution of meiotic recombination intermediates (GO:0000712)2.97202963
94regulation of histone H3-K9 methylation (GO:0051570)2.96777418
95synapsis (GO:0007129)2.95838779
96double-strand break repair via nonhomologous end joining (GO:0006303)2.95660827
97non-recombinational repair (GO:0000726)2.95660827
98nucleobase biosynthetic process (GO:0046112)2.95632741
99IMP metabolic process (GO:0046040)2.91788025
100ribosome assembly (GO:0042255)2.88185088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.10624664
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.99840851
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.46162272
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.42916471
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.92421242
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36709524
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.29193760
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16297996
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.14119815
10AR_21909140_ChIP-Seq_LNCAP_Human3.05570696
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77037556
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67603290
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66812931
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59742812
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.40294881
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.32587635
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30945352
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28907250
19XRN2_22483619_ChIP-Seq_HELA_Human2.22964720
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.20867521
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16013898
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10581634
23MYCN_18555785_ChIP-Seq_MESCs_Mouse2.10157339
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.09542213
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05078483
26DCP1A_22483619_ChIP-Seq_HELA_Human2.05073261
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.98273249
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96699615
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91161824
30TTF2_22483619_ChIP-Seq_HELA_Human1.89950119
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87834414
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.86652012
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80296785
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78471410
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74923558
36MYC_22102868_ChIP-Seq_BL_Human1.69838369
37FOXP3_21729870_ChIP-Seq_TREG_Human1.67494538
38GABP_19822575_ChIP-Seq_HepG2_Human1.56772023
39KDM5A_27292631_Chip-Seq_BREAST_Human1.56110944
40ELK1_19687146_ChIP-ChIP_HELA_Human1.54977743
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53000528
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51175669
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50831111
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48399925
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48118803
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47756054
47VDR_23849224_ChIP-Seq_CD4+_Human1.46977984
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.44620101
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42563992
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42517586
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41438285
52E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.40113192
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37882773
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36904318
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34989453
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28425279
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25254481
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23351055
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19523092
60CIITA_25753668_ChIP-Seq_RAJI_Human1.17123634
61ZNF263_19887448_ChIP-Seq_K562_Human1.16306799
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15269329
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13918654
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12933291
65TFEB_21752829_ChIP-Seq_HELA_Human1.11124439
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05336070
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04526314
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03960434
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02687811
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.02526955
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.01683181
72ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98705636
73RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96747782
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96062992
75* CHD1_26751641_Chip-Seq_LNCaP_Human0.95822290
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93881022
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91139869
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90328482
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88932652
80SOX17_20123909_ChIP-Seq_XEN_Mouse0.88565161
81NCOR1_26117541_ChIP-Seq_K562_Human0.88129597
82TP63_19390658_ChIP-ChIP_HaCaT_Human0.86751742
83MYC_18940864_ChIP-ChIP_HL60_Human0.83763911
84SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83586323
85NANOG_21062744_ChIP-ChIP_HESCs_Human0.83581071
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82268607
87SALL1_21062744_ChIP-ChIP_HESCs_Human0.81115821
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80765616
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79780628
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79747380
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76827120
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75948835
93TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75136956
94VDR_21846776_ChIP-Seq_THP-1_Human0.75098421
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74946653
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74644565
97TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74598327
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74223953
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.71395331
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71158225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.71088799
2MP0010094_abnormal_chromosome_stability5.38990320
3MP0003111_abnormal_nucleus_morphology5.30489472
4MP0004957_abnormal_blastocyst_morpholog4.62476346
5MP0003077_abnormal_cell_cycle4.38510007
6MP0008057_abnormal_DNA_replication4.26770006
7MP0008058_abnormal_DNA_repair3.71151377
8MP0008932_abnormal_embryonic_tissue3.21569808
9MP0008007_abnormal_cellular_replicative2.90824000
10MP0001730_embryonic_growth_arrest2.52270448
11MP0000350_abnormal_cell_proliferation2.37369749
12MP0003718_maternal_effect2.13018507
13MP0002877_abnormal_melanocyte_morpholog2.12984996
14MP0010307_abnormal_tumor_latency2.12370878
15MP0009697_abnormal_copulation2.08326441
16MP0001697_abnormal_embryo_size1.97867816
17MP0005380_embryogenesis_phenotype1.93342170
18MP0001672_abnormal_embryogenesis/_devel1.93342170
19MP0005076_abnormal_cell_differentiation1.86207367
20MP0002080_prenatal_lethality1.80428480
21MP0003786_premature_aging1.79494561
22MP0002396_abnormal_hematopoietic_system1.75314320
23MP0000313_abnormal_cell_death1.72278293
24MP0003984_embryonic_growth_retardation1.70178493
25MP0002088_abnormal_embryonic_growth/wei1.62942671
26MP0004233_abnormal_muscle_weight1.61102477
27MP0010352_gastrointestinal_tract_polyps1.60704254
28MP0004185_abnormal_adipocyte_glucose1.50786635
29MP0002085_abnormal_embryonic_tissue1.50703272
30MP0005451_abnormal_body_composition1.47619663
31MP0009672_abnormal_birth_weight1.41180488
32MP0002084_abnormal_developmental_patter1.40919381
33MP0002086_abnormal_extraembryonic_tissu1.39924897
34MP0003656_abnormal_erythrocyte_physiolo1.32457957
35MP0002210_abnormal_sex_determination1.30513449
36MP0002009_preneoplasia1.30195565
37MP0006035_abnormal_mitochondrial_morpho1.27952446
38MP0004808_abnormal_hematopoietic_stem1.27747638
39MP0010234_abnormal_vibrissa_follicle1.27138345
40MP0003890_abnormal_embryonic-extraembry1.25472879
41MP0004197_abnormal_fetal_growth/weight/1.23384562
42MP0006292_abnormal_olfactory_placode1.23335436
43MP0002019_abnormal_tumor_incidence1.23098943
44MP0003941_abnormal_skin_development1.21391546
45MP0004147_increased_porphyrin_level1.18706516
46MP0001929_abnormal_gametogenesis1.17689601
47MP0003705_abnormal_hypodermis_morpholog1.14600859
48MP0000358_abnormal_cell_content/1.12798278
49MP0005501_abnormal_skin_physiology1.12627585
50MP0008995_early_reproductive_senescence1.11293463
51MP0000490_abnormal_crypts_of1.11041713
52MP0003806_abnormal_nucleotide_metabolis1.09004502
53MP0000678_abnormal_parathyroid_gland1.08737558
54MP0001661_extended_life_span1.04534438
55MP0001145_abnormal_male_reproductive1.03965086
56MP0003221_abnormal_cardiomyocyte_apopto1.02607927
57MP0002796_impaired_skin_barrier1.01636173
58MP0005621_abnormal_cell_physiology0.95643010
59MP0005384_cellular_phenotype0.93821710
60MP0008877_abnormal_DNA_methylation0.90910780
61MP0006036_abnormal_mitochondrial_physio0.89435149
62MP0000653_abnormal_sex_gland0.89341237
63MP0003937_abnormal_limbs/digits/tail_de0.89293873
64MP0000703_abnormal_thymus_morphology0.85841471
65MP0003699_abnormal_female_reproductive0.85338994
66MP0001727_abnormal_embryo_implantation0.83065585
67MP0001293_anophthalmia0.82840544
68MP0003567_abnormal_fetal_cardiomyocyte0.81139022
69MP0009703_decreased_birth_body0.81024958
70MP0002697_abnormal_eye_size0.79124976
71MP0001346_abnormal_lacrimal_gland0.75028703
72MP0010030_abnormal_orbit_morphology0.73446958
73MP0002111_abnormal_tail_morphology0.72623477
74MP0002161_abnormal_fertility/fecundity0.72438755
75MP0003186_abnormal_redox_activity0.69810794
76MP0001881_abnormal_mammary_gland0.68245013
77MP0003698_abnormal_male_reproductive0.67772284
78MP0003315_abnormal_perineum_morphology0.67523436
79MP0000428_abnormal_craniofacial_morphol0.67394787
80MP0000537_abnormal_urethra_morphology0.65830232
81MP0004264_abnormal_extraembryonic_tissu0.62122485
82MP0002092_abnormal_eye_morphology0.61941351
83MP0003950_abnormal_plasma_membrane0.61937965
84MP0001286_abnormal_eye_development0.61917465
85MP0001119_abnormal_female_reproductive0.60990172
86MP0003943_abnormal_hepatobiliary_system0.59750137
87MP0002160_abnormal_reproductive_system0.59551915
88MP0001853_heart_inflammation0.58916469
89MP0003453_abnormal_keratinocyte_physiol0.58200388
90MP0005395_other_phenotype0.57530688
91MP0003123_paternal_imprinting0.57457116
92MP0002722_abnormal_immune_system0.55044089
93MP0002398_abnormal_bone_marrow0.55010538
94MP0002269_muscular_atrophy0.54478774
95MP0002970_abnormal_white_adipose0.54347401
96MP0001915_intracranial_hemorrhage0.54145986
97MP0001216_abnormal_epidermal_layer0.53960505
98MP0000627_abnormal_mammary_gland0.52023888
99MP0003566_abnormal_cell_adhesion0.52012143
100MP0003861_abnormal_nervous_system0.50782101

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.14965359
2Chromsome breakage (HP:0040012)5.93584944
3Increased nuchal translucency (HP:0010880)4.19251979
4Cortical dysplasia (HP:0002539)3.86964432
5Abnormality of chromosome stability (HP:0003220)3.64903566
6Abnormality of the preputium (HP:0100587)3.64726699
7Nephroblastoma (Wilms tumor) (HP:0002667)3.60821289
8Birth length less than 3rd percentile (HP:0003561)3.49908251
9Meckel diverticulum (HP:0002245)3.48775053
10Small intestinal stenosis (HP:0012848)3.44943132
11Duodenal stenosis (HP:0100867)3.44943132
12Reticulocytopenia (HP:0001896)3.42855784
13Embryonal renal neoplasm (HP:0011794)3.38427858
14Abnormal lung lobation (HP:0002101)3.36242690
15Myelodysplasia (HP:0002863)3.29766366
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.28631023
17Abnormality of the ileum (HP:0001549)3.26763625
18Abnormal gallbladder physiology (HP:0012438)3.13512231
19Cholecystitis (HP:0001082)3.13512231
20Aplasia/Hypoplasia of the sacrum (HP:0008517)2.84247116
21Volvulus (HP:0002580)2.82479809
22Abnormality of the duodenum (HP:0002246)2.79642919
23Progressive external ophthalmoplegia (HP:0000590)2.79276756
24Progressive muscle weakness (HP:0003323)2.76313190
25Abnormality of reticulocytes (HP:0004312)2.73242716
26Microvesicular hepatic steatosis (HP:0001414)2.72365546
27Cafe-au-lait spot (HP:0000957)2.70494338
28Overlapping toe (HP:0001845)2.67145247
29Abnormality of the carotid arteries (HP:0005344)2.52240304
30Multiple enchondromatosis (HP:0005701)2.44214665
31Proximal placement of thumb (HP:0009623)2.44185424
32Abnormality of glycolysis (HP:0004366)2.40929499
33Reticulocytosis (HP:0001923)2.40268104
34Sloping forehead (HP:0000340)2.40245711
35Deviation of the thumb (HP:0009603)2.34027274
36Abnormality of cells of the erythroid lineage (HP:0012130)2.33653583
37Rhabdomyosarcoma (HP:0002859)2.33109452
38Squamous cell carcinoma (HP:0002860)2.30987752
39Deep philtrum (HP:0002002)2.30378634
40Abnormality of chromosome segregation (HP:0002916)2.29426103
41Embryonal neoplasm (HP:0002898)2.28644569
42Horseshoe kidney (HP:0000085)2.28089620
43Absent radius (HP:0003974)2.26760728
44Choanal atresia (HP:0000453)2.22797949
45Abnormality of cochlea (HP:0000375)2.21489429
46Increased serum pyruvate (HP:0003542)2.20224561
47Selective tooth agenesis (HP:0001592)2.20223177
48Breast hypoplasia (HP:0003187)2.20152811
49Ectopic kidney (HP:0000086)2.19101245
50Premature ovarian failure (HP:0008209)2.18618996
51Pallor (HP:0000980)2.17469484
52Ankyloglossia (HP:0010296)2.13830487
53Duplicated collecting system (HP:0000081)2.09635486
54Missing ribs (HP:0000921)2.07435179
55Aplasia involving forearm bones (HP:0009822)2.06446926
56Absent forearm bone (HP:0003953)2.06446926
5711 pairs of ribs (HP:0000878)2.06424245
58Neoplasm of the colon (HP:0100273)2.04827501
59Arteriovenous malformation (HP:0100026)2.02183228
60Abnormal number of erythroid precursors (HP:0012131)1.96181576
61Macrocytic anemia (HP:0001972)1.95529724
62Acute myeloid leukemia (HP:0004808)1.95416029
63Medulloblastoma (HP:0002885)1.94248228
64Carpal bone hypoplasia (HP:0001498)1.93276686
65Orthostatic hypotension (HP:0001278)1.92625500
66Abnormality of DNA repair (HP:0003254)1.89026088
67Poikiloderma (HP:0001029)1.86577923
68Septate vagina (HP:0001153)1.86091939
69Absent thumb (HP:0009777)1.84388087
70Facial hemangioma (HP:0000329)1.83786431
71Insomnia (HP:0100785)1.83640882
72Aplasia/Hypoplasia of the sternum (HP:0006714)1.83192813
73Triphalangeal thumb (HP:0001199)1.82500512
74Clubbing of toes (HP:0100760)1.81954034
75Microglossia (HP:0000171)1.79308987
76Cholelithiasis (HP:0001081)1.79095102
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78707677
78Bone marrow hypocellularity (HP:0005528)1.78135424
79Atresia of the external auditory canal (HP:0000413)1.77259689
80Hypergonadotropic hypogonadism (HP:0000815)1.76665072
81Abnormality of the fetal cardiovascular system (HP:0010948)1.75815420
82Abnormal umbilical cord blood vessels (HP:0011403)1.75815420
83Single umbilical artery (HP:0001195)1.75815420
84Ureteral duplication (HP:0000073)1.72966626
85Duplication of thumb phalanx (HP:0009942)1.72622420
86Uterine leiomyosarcoma (HP:0002891)1.71931357
87Leiomyosarcoma (HP:0100243)1.71931357
88Nonimmune hydrops fetalis (HP:0001790)1.71381285
89Abnormality of the renal collecting system (HP:0004742)1.71227728
90Secondary amenorrhea (HP:0000869)1.70653402
91Short middle phalanx of the 5th finger (HP:0004220)1.70503312
92Insidious onset (HP:0003587)1.69763100
93Termporal pattern (HP:0011008)1.69763100
94Truncus arteriosus (HP:0001660)1.68327873
95Upper limb muscle weakness (HP:0003484)1.68090339
96Sandal gap (HP:0001852)1.66474531
97Abnormality of the umbilical cord (HP:0010881)1.66317653
98Ependymoma (HP:0002888)1.65480995
99Obsessive-compulsive behavior (HP:0000722)1.64801334
100Hypoparathyroidism (HP:0000829)1.63462795

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.86500604
2TTK4.61733101
3CDC73.68181602
4NEK13.07316151
5WEE12.93033426
6SRPK12.85004704
7PBK2.76463248
8EIF2AK12.69018934
9PLK42.55315404
10NEK22.26793153
11TSSK62.13107641
12CDK122.04498441
13BRSK22.02607854
14PLK11.87494913
15SCYL21.87077066
16PLK31.84594269
17CHEK21.79125517
18MAP3K101.76170883
19NME21.73396751
20BRSK11.72967603
21BRAF1.61619733
22SMG11.61596762
23EEF2K1.56478210
24EIF2AK31.54554404
25VRK21.53329848
26AURKB1.50819020
27MAP3K81.45776980
28ATR1.43823201
29CCNB11.38058561
30RPS6KB21.36822540
31CHEK11.34450850
32CLK11.33394530
33CDK71.30075521
34TAF11.28108041
35STK101.24680939
36MKNK11.23607608
37MST41.20362506
38AURKA1.16699949
39CDK41.15088131
40STK41.11408790
41ZAK1.00459801
42PNCK0.98243634
43EIF2AK20.94910396
44IRAK30.93420028
45KSR20.91166934
46RPS6KA40.90585639
47ICK0.90525767
48MST1R0.89080826
49ATM0.87346969
50MKNK20.87137272
51BRD40.86256843
52RAF10.84708556
53CDK10.83062304
54CDK80.81533211
55LATS20.80988949
56VRK10.77395804
57TRIB30.77314487
58STK30.75485253
59ALK0.74894936
60CDK20.74119861
61DYRK30.71162319
62NME10.70324544
63MET0.70139707
64STK160.70099677
65PAK40.68470429
66PASK0.68261798
67PRPF4B0.67695960
68CDK60.64440784
69BMX0.62429754
70MELK0.61412812
71ARAF0.51943721
72KSR10.51828850
73CDK11A0.49866459
74CSNK2A20.49512875
75PAK10.48779426
76BMPR20.48737728
77CSNK2A10.45449189
78CDK150.44810159
79CDK180.43993686
80MTOR0.43758982
81MAP3K90.42250015
82TAOK20.41110079
83AKT20.40183244
84TESK20.39619769
85CSNK1E0.38576626
86CDK140.38097083
87CDK30.37710816
88YES10.36352839
89CDK90.36135670
90PRKCI0.35843321
91ERBB40.33213532
92TRIM280.32894853
93MARK30.29593060
94PRKDC0.29567788
95MAP3K130.28915485
96NEK90.28741275
97MAPK140.26685225
98PDK20.26175030
99PIM10.24681156
100DMPK0.20969122

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.94926135
2Mismatch repair_Homo sapiens_hsa034304.25135249
3Cell cycle_Homo sapiens_hsa041103.56037840
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.28909068
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14415173
6Homologous recombination_Homo sapiens_hsa034403.05389912
7Base excision repair_Homo sapiens_hsa034102.99104406
8Spliceosome_Homo sapiens_hsa030402.92829372
9RNA transport_Homo sapiens_hsa030132.88342476
10Nucleotide excision repair_Homo sapiens_hsa034202.74332817
11Non-homologous end-joining_Homo sapiens_hsa034502.68297278
12Fanconi anemia pathway_Homo sapiens_hsa034602.62067870
13One carbon pool by folate_Homo sapiens_hsa006702.48261432
14Ribosome_Homo sapiens_hsa030102.26422094
15Proteasome_Homo sapiens_hsa030502.12676955
16mRNA surveillance pathway_Homo sapiens_hsa030152.02195483
17Pyrimidine metabolism_Homo sapiens_hsa002401.73330605
18Basal transcription factors_Homo sapiens_hsa030221.68134080
19RNA polymerase_Homo sapiens_hsa030201.66055892
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65016526
21RNA degradation_Homo sapiens_hsa030181.56167687
22Oocyte meiosis_Homo sapiens_hsa041141.55088443
23Biosynthesis of amino acids_Homo sapiens_hsa012301.49898785
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45925252
25p53 signaling pathway_Homo sapiens_hsa041151.31390652
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26599345
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.24599211
28Thyroid cancer_Homo sapiens_hsa052161.14790478
29Carbon metabolism_Homo sapiens_hsa012001.13310832
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11600869
31Pentose phosphate pathway_Homo sapiens_hsa000301.10818538
32Pyruvate metabolism_Homo sapiens_hsa006201.03317869
33Chronic myeloid leukemia_Homo sapiens_hsa052201.02503958
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01508499
35Steroid biosynthesis_Homo sapiens_hsa001000.96502590
36Purine metabolism_Homo sapiens_hsa002300.95775740
37Viral carcinogenesis_Homo sapiens_hsa052030.95204169
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92988882
39Epstein-Barr virus infection_Homo sapiens_hsa051690.87459671
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86121809
41MicroRNAs in cancer_Homo sapiens_hsa052060.85633219
42Central carbon metabolism in cancer_Homo sapiens_hsa052300.85295853
43Selenocompound metabolism_Homo sapiens_hsa004500.79282308
44Bladder cancer_Homo sapiens_hsa052190.77155470
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76574862
46N-Glycan biosynthesis_Homo sapiens_hsa005100.76165687
47Pancreatic cancer_Homo sapiens_hsa052120.75417812
48Folate biosynthesis_Homo sapiens_hsa007900.74553577
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71888441
50Non-small cell lung cancer_Homo sapiens_hsa052230.71449625
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70320575
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70201815
53HTLV-I infection_Homo sapiens_hsa051660.66413891
54Protein export_Homo sapiens_hsa030600.66325092
55Sulfur relay system_Homo sapiens_hsa041220.66160407
56Small cell lung cancer_Homo sapiens_hsa052220.64558938
57Acute myeloid leukemia_Homo sapiens_hsa052210.61480621
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60641494
59Lysine degradation_Homo sapiens_hsa003100.56390796
60Fatty acid elongation_Homo sapiens_hsa000620.55090796
61Herpes simplex infection_Homo sapiens_hsa051680.54753156
62Prostate cancer_Homo sapiens_hsa052150.54040829
63Vitamin B6 metabolism_Homo sapiens_hsa007500.53556037
64Fructose and mannose metabolism_Homo sapiens_hsa000510.53408257
65Colorectal cancer_Homo sapiens_hsa052100.53165585
66Hepatitis B_Homo sapiens_hsa051610.51890514
67Renal cell carcinoma_Homo sapiens_hsa052110.45007153
68Apoptosis_Homo sapiens_hsa042100.43882694
69Huntingtons disease_Homo sapiens_hsa050160.43044113
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42116407
71Adherens junction_Homo sapiens_hsa045200.41587534
72Shigellosis_Homo sapiens_hsa051310.39923041
73Glutathione metabolism_Homo sapiens_hsa004800.39547141
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34160615
75Systemic lupus erythematosus_Homo sapiens_hsa053220.33560727
76Glioma_Homo sapiens_hsa052140.33417449
77Endometrial cancer_Homo sapiens_hsa052130.33187845
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33184031
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31548657
80Galactose metabolism_Homo sapiens_hsa000520.29116910
81Alcoholism_Homo sapiens_hsa050340.28969771
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28503897
83mTOR signaling pathway_Homo sapiens_hsa041500.28052417
84ErbB signaling pathway_Homo sapiens_hsa040120.27844134
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26226582
86HIF-1 signaling pathway_Homo sapiens_hsa040660.26105181
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23698345
88Melanoma_Homo sapiens_hsa052180.22865404
89Parkinsons disease_Homo sapiens_hsa050120.21915587
90Insulin signaling pathway_Homo sapiens_hsa049100.20993659
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20311046
92TGF-beta signaling pathway_Homo sapiens_hsa043500.19951037
93Metabolic pathways_Homo sapiens_hsa011000.19523022
94AMPK signaling pathway_Homo sapiens_hsa041520.19296828
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19169234
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18938254
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18090414
98B cell receptor signaling pathway_Homo sapiens_hsa046620.17680142
99Propanoate metabolism_Homo sapiens_hsa006400.17479027
100Fatty acid metabolism_Homo sapiens_hsa012120.15498072

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