FAM72A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.22503094
2mitotic metaphase plate congression (GO:0007080)5.65728890
3protein localization to chromosome, centromeric region (GO:0071459)5.60165262
4DNA topological change (GO:0006265)5.40860971
5attachment of spindle microtubules to kinetochore (GO:0008608)4.86558717
6mitotic sister chromatid segregation (GO:0000070)4.82917640
7metaphase plate congression (GO:0051310)4.79975313
8regulation of spindle organization (GO:0090224)4.77520725
9mitotic chromosome condensation (GO:0007076)4.73172179
10DNA ligation (GO:0006266)4.62942224
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.59558758
12establishment of chromosome localization (GO:0051303)4.51501950
13DNA replication checkpoint (GO:0000076)4.50958991
14mitotic nuclear envelope disassembly (GO:0007077)4.34352022
15CENP-A containing nucleosome assembly (GO:0034080)4.32830067
16DNA replication initiation (GO:0006270)4.27020465
17sister chromatid segregation (GO:0000819)4.25613528
18DNA strand elongation involved in DNA replication (GO:0006271)4.20070347
19chromatin remodeling at centromere (GO:0031055)4.19551477
20protein localization to chromosome (GO:0034502)4.12528378
21folic acid-containing compound biosynthetic process (GO:0009396)4.12029746
22kinetochore organization (GO:0051383)4.11699429
23DNA strand elongation (GO:0022616)4.06272538
24meiotic chromosome segregation (GO:0045132)4.04339307
25establishment of integrated proviral latency (GO:0075713)4.01317509
26positive regulation of chromosome segregation (GO:0051984)4.00205611
27membrane disassembly (GO:0030397)3.99167149
28nuclear envelope disassembly (GO:0051081)3.99167149
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.97166544
30regulation of mitotic spindle organization (GO:0060236)3.96197958
31telomere maintenance via semi-conservative replication (GO:0032201)3.95069117
32pore complex assembly (GO:0046931)3.93778601
33microtubule depolymerization (GO:0007019)3.84922909
34purine nucleobase biosynthetic process (GO:0009113)3.81233073
35DNA replication-independent nucleosome assembly (GO:0006336)3.80428367
36DNA replication-independent nucleosome organization (GO:0034724)3.80428367
37kinetochore assembly (GO:0051382)3.76903977
38DNA unwinding involved in DNA replication (GO:0006268)3.76757517
39DNA packaging (GO:0006323)3.76271556
40nucleobase biosynthetic process (GO:0046112)3.73771115
41spindle checkpoint (GO:0031577)3.67428765
42regulation of chromosome segregation (GO:0051983)3.67205042
43telomere maintenance via recombination (GO:0000722)3.63396339
44histone exchange (GO:0043486)3.60480526
45chromosome segregation (GO:0007059)3.60129141
46ribosomal small subunit biogenesis (GO:0042274)3.60038571
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.58597043
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.58597043
49positive regulation of mitotic sister chromatid separation (GO:1901970)3.58597043
50mitotic recombination (GO:0006312)3.55242997
51protein K6-linked ubiquitination (GO:0085020)3.53359882
52regulation of sister chromatid cohesion (GO:0007063)3.45281840
53regulation of centriole replication (GO:0046599)3.44701479
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.39677418
55negative regulation of chromosome segregation (GO:0051985)3.37744792
56regulation of translational fidelity (GO:0006450)3.37728549
57regulation of exit from mitosis (GO:0007096)3.36652167
58negative regulation of mitosis (GO:0045839)3.35319992
59regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.34978167
60ribosome assembly (GO:0042255)3.34049108
61regulation of telomere maintenance via telomerase (GO:0032210)3.32534523
62maturation of SSU-rRNA (GO:0030490)3.32506868
63DNA deamination (GO:0045006)3.31224044
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.30391883
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30391883
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30391883
67negative regulation of sister chromatid segregation (GO:0033046)3.30391883
68regulation of mitotic metaphase/anaphase transition (GO:0030071)3.27742774
69spindle assembly checkpoint (GO:0071173)3.27501688
70nuclear envelope organization (GO:0006998)3.22318594
71DNA conformation change (GO:0071103)3.21226091
72ribosomal small subunit assembly (GO:0000028)3.20754151
73mitotic spindle checkpoint (GO:0071174)3.19730093
74mitotic spindle assembly checkpoint (GO:0007094)3.19281954
75telomere maintenance via telomere lengthening (GO:0010833)3.18825363
76DNA replication-dependent nucleosome assembly (GO:0006335)3.17435220
77DNA replication-dependent nucleosome organization (GO:0034723)3.17435220
78viral transcription (GO:0019083)3.16374057
79translational termination (GO:0006415)3.14450185
80chromatin assembly or disassembly (GO:0006333)3.13723934
81resolution of meiotic recombination intermediates (GO:0000712)3.11974504
82folic acid metabolic process (GO:0046655)3.11733984
83regulation of sister chromatid segregation (GO:0033045)3.09490646
84regulation of mitotic sister chromatid separation (GO:0010965)3.09490646
85regulation of mitotic sister chromatid segregation (GO:0033047)3.09490646
86formation of translation preinitiation complex (GO:0001731)3.08482218
87IMP biosynthetic process (GO:0006188)3.07727271
88establishment of viral latency (GO:0019043)3.07675180
89ribosomal large subunit biogenesis (GO:0042273)3.06204427
90mitotic sister chromatid cohesion (GO:0007064)3.05183247
91negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.04492142
92IMP metabolic process (GO:0046040)3.03148215
93regulation of DNA endoreduplication (GO:0032875)3.03109989
94histone-serine phosphorylation (GO:0035404)2.99856373
95nuclear pore organization (GO:0006999)2.99573306
96ribonucleoprotein complex biogenesis (GO:0022613)2.99324153
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98990975
98ribosome biogenesis (GO:0042254)2.98816528
99nucleotide-excision repair, DNA gap filling (GO:0006297)2.97874111
100protein complex localization (GO:0031503)2.96417091
101chromosome organization (GO:0051276)2.94423865
102negative regulation of cell division (GO:0051782)2.93213105
103synapsis (GO:0007129)2.92551643
104mitotic cell cycle (GO:0000278)2.92108050
105regulation of centrosome cycle (GO:0046605)2.90052346
106chromosome condensation (GO:0030261)2.89461563
107spliceosomal snRNP assembly (GO:0000387)2.82398397
108nuclear pore complex assembly (GO:0051292)2.81943386
109regulation of double-strand break repair via homologous recombination (GO:0010569)2.80932765
110rRNA modification (GO:0000154)2.78874754
111ATP-dependent chromatin remodeling (GO:0043044)2.77225252
112negative regulation of telomere maintenance (GO:0032205)2.73626062
113cell cycle G1/S phase transition (GO:0044843)2.71439846
114G1/S transition of mitotic cell cycle (GO:0000082)2.71439846
115mismatch repair (GO:0006298)2.71183973
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66556160
117regulation of histone H3-K27 methylation (GO:0061085)2.66420790
118DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.64737043
119DNA duplex unwinding (GO:0032508)2.64603989
120DNA geometric change (GO:0032392)2.64559872
121maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64100839
122telomere maintenance (GO:0000723)2.63607398
123telomere organization (GO:0032200)2.61994386
124mitotic nuclear division (GO:0007067)2.61844387
125mitotic G2/M transition checkpoint (GO:0044818)2.61563774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.69088676
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.16831261
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06780447
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.92461511
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.51091002
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92451226
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87405069
8AR_21909140_ChIP-Seq_LNCAP_Human2.54986646
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45551260
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44520992
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.43349955
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.41263018
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.40352600
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.39285833
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33495612
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33264377
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32305412
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30144058
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29795397
20XRN2_22483619_ChIP-Seq_HELA_Human2.15368504
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.06727863
22VDR_23849224_ChIP-Seq_CD4+_Human2.01764690
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96332667
24DCP1A_22483619_ChIP-Seq_HELA_Human1.94440764
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91714642
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90688640
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83926781
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83877538
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82778645
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82231183
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81742621
32FOXP3_21729870_ChIP-Seq_TREG_Human1.79325448
33GABP_19822575_ChIP-Seq_HepG2_Human1.72043541
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71794547
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62469682
36MYC_22102868_ChIP-Seq_BL_Human1.61914656
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58693268
38CIITA_25753668_ChIP-Seq_RAJI_Human1.57742205
39TTF2_22483619_ChIP-Seq_HELA_Human1.57521301
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56459955
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55461797
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54782547
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54437615
44* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52884013
45KDM5A_27292631_Chip-Seq_BREAST_Human1.51767833
46* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45255901
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44038364
48ELK1_19687146_ChIP-ChIP_HELA_Human1.39700892
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39242055
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37158457
51E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.36880581
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33265381
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32091010
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29834748
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.29639050
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29374359
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29003623
58TFEB_21752829_ChIP-Seq_HELA_Human1.28591476
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27340347
60VDR_21846776_ChIP-Seq_THP-1_Human1.27142738
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26546033
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.25563577
63* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25559126
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24694452
65SPI1_23547873_ChIP-Seq_NB4_Human1.20588005
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.19328142
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.18469008
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16916188
69ZNF263_19887448_ChIP-Seq_K562_Human1.16260145
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13056243
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12793440
72* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11554885
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11181023
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09947201
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07787820
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06454493
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05681097
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03112490
79MYC_18940864_ChIP-ChIP_HL60_Human1.01338386
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00936212
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99399898
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99298488
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98188509
84TP63_19390658_ChIP-ChIP_HaCaT_Human0.97704576
85BP1_19119308_ChIP-ChIP_Hs578T_Human0.97284956
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94574706
87GATA1_22025678_ChIP-Seq_K562_Human0.94011028
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93210917
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90828016
90SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87654976
91NCOR1_26117541_ChIP-Seq_K562_Human0.87372726
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87368134
93* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87252131
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86604540
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86058476
96* MYB_26560356_Chip-Seq_TH2_Human0.85541446
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83635506
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83362815
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.82840491
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82789590
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81837413
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81561675
103SALL1_21062744_ChIP-ChIP_HESCs_Human0.80826662
104* CHD1_26751641_Chip-Seq_LNCaP_Human0.80453301
105BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79932060
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79550990
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.79320727
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79001394
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.77399282
110* MYB_26560356_Chip-Seq_TH1_Human0.76414200
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76308629
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74783253
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.74628218
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74209687
115SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.74097487
116* RUNX1_22412390_ChIP-Seq_EML_Mouse0.73411159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.89953345
2MP0003111_abnormal_nucleus_morphology5.03216698
3MP0010094_abnormal_chromosome_stability4.70326776
4MP0003077_abnormal_cell_cycle4.27913363
5MP0008057_abnormal_DNA_replication4.26735637
6MP0004957_abnormal_blastocyst_morpholog4.03018274
7MP0008007_abnormal_cellular_replicative2.77148958
8MP0008058_abnormal_DNA_repair2.64309694
9MP0003718_maternal_effect2.44687542
10MP0010307_abnormal_tumor_latency2.34683746
11MP0000350_abnormal_cell_proliferation2.32725864
12MP0008932_abnormal_embryonic_tissue2.30112444
13MP0002396_abnormal_hematopoietic_system2.28006022
14MP0009697_abnormal_copulation2.21514198
15MP0001730_embryonic_growth_arrest2.16937936
16MP0000490_abnormal_crypts_of1.81690286
17MP0004808_abnormal_hematopoietic_stem1.78225182
18MP0010352_gastrointestinal_tract_polyps1.74001957
19MP0005076_abnormal_cell_differentiation1.71089319
20MP0002877_abnormal_melanocyte_morpholog1.67689402
21MP0002019_abnormal_tumor_incidence1.66667064
22MP0001697_abnormal_embryo_size1.63928115
23MP0001672_abnormal_embryogenesis/_devel1.60315131
24MP0005380_embryogenesis_phenotype1.60315131
25MP0008877_abnormal_DNA_methylation1.55492056
26MP0000313_abnormal_cell_death1.50480209
27MP0010030_abnormal_orbit_morphology1.47708253
28MP0002080_prenatal_lethality1.45237711
29MP0009333_abnormal_splenocyte_physiolog1.45107773
30MP0002398_abnormal_bone_marrow1.44962915
31MP0003984_embryonic_growth_retardation1.43116116
32MP0005397_hematopoietic_system_phenotyp1.42951406
33MP0001545_abnormal_hematopoietic_system1.42951406
34MP0009379_abnormal_foot_pigmentation1.38797079
35MP0006054_spinal_hemorrhage1.38232519
36MP0002088_abnormal_embryonic_growth/wei1.38144065
37MP0006035_abnormal_mitochondrial_morpho1.35656770
38MP0002085_abnormal_embryonic_tissue1.34637538
39MP0003786_premature_aging1.30676795
40MP0000689_abnormal_spleen_morphology1.29860156
41MP0002722_abnormal_immune_system1.29332483
42MP0003941_abnormal_skin_development1.27744376
43MP0003123_paternal_imprinting1.27644874
44MP0004185_abnormal_adipocyte_glucose1.27530662
45MP0001293_anophthalmia1.25652768
46MP0002086_abnormal_extraembryonic_tissu1.24903839
47MP0002210_abnormal_sex_determination1.22474166
48MP0000703_abnormal_thymus_morphology1.20747597
49MP0003221_abnormal_cardiomyocyte_apopto1.20709403
50MP0001800_abnormal_humoral_immune1.18940020
51MP0005451_abnormal_body_composition1.18742072
52MP0003763_abnormal_thymus_physiology1.17946629
53MP0000858_altered_metastatic_potential1.16601003
54MP0003136_yellow_coat_color1.14122510
55MP0001915_intracranial_hemorrhage1.13393016
56MP0002429_abnormal_blood_cell1.12593966
57MP0002452_abnormal_antigen_presenting1.10959504
58MP0002084_abnormal_developmental_patter1.10399134
59MP0001119_abnormal_female_reproductive1.09331224
60MP0000716_abnormal_immune_system1.08992518
61MP0001929_abnormal_gametogenesis1.07917604
62MP0009840_abnormal_foam_cell1.07236844
63MP0006036_abnormal_mitochondrial_physio1.06330715
64MP0003303_peritoneal_inflammation1.03697599
65MP0003646_muscle_fatigue1.03596712
66MP0001835_abnormal_antigen_presentation1.02962327
67MP0002420_abnormal_adaptive_immunity1.01973670
68MP0005621_abnormal_cell_physiology1.01712780
69MP0001819_abnormal_immune_cell1.01559695
70MP0003806_abnormal_nucleotide_metabolis1.00735429
71MP0002102_abnormal_ear_morphology1.00471306
72MP0006292_abnormal_olfactory_placode1.00238673
73MP0002723_abnormal_immune_serum1.00227063
74MP0000685_abnormal_immune_system1.00126619
75MP0008995_early_reproductive_senescence0.99941012
76MP0003937_abnormal_limbs/digits/tail_de0.99578589
77MP0003436_decreased_susceptibility_to0.98938977
78MP0002697_abnormal_eye_size0.98650522
79MP0001145_abnormal_male_reproductive0.98626805
80MP0006082_CNS_inflammation0.98129241
81MP0000653_abnormal_sex_gland0.97831658
82MP0003186_abnormal_redox_activity0.94605603
83MP0004197_abnormal_fetal_growth/weight/0.92571346
84MP0009278_abnormal_bone_marrow0.92353944
85MP0004233_abnormal_muscle_weight0.92263184
86MP0001286_abnormal_eye_development0.90235682
87MP0003448_altered_tumor_morphology0.89855498
88MP0003705_abnormal_hypodermis_morpholog0.89801603
89MP0001346_abnormal_lacrimal_gland0.89135724
90MP0009785_altered_susceptibility_to0.88998911
91MP0005384_cellular_phenotype0.87872042
92MP0002111_abnormal_tail_morphology0.86999095
93MP0005000_abnormal_immune_tolerance0.86882083
94MP0003699_abnormal_female_reproductive0.86719404
95MP0005671_abnormal_response_to0.85162103
96MP0002419_abnormal_innate_immunity0.84554430
97MP0005501_abnormal_skin_physiology0.81821733
98MP0001881_abnormal_mammary_gland0.81683255
99MP0005025_abnormal_response_to0.81666162
100MP0001661_extended_life_span0.81375313
101MP0002132_abnormal_respiratory_system0.81253578
102MP0002938_white_spotting0.80596088
103MP0005464_abnormal_platelet_physiology0.79583317
104MP0002092_abnormal_eye_morphology0.77476657
105MP0009703_decreased_birth_body0.76483353
106MP0003566_abnormal_cell_adhesion0.75822174
107MP0001727_abnormal_embryo_implantation0.75272045
108MP0002009_preneoplasia0.74872335
109MP0005408_hypopigmentation0.73628903
110MP0003828_pulmonary_edema0.72849681
111MP0010155_abnormal_intestine_physiology0.72148511
112MP0002405_respiratory_system_inflammati0.71830197
113MP0000465_gastrointestinal_hemorrhage0.71536942
114MP0003890_abnormal_embryonic-extraembry0.71342176
115MP0005395_other_phenotype0.71071512
116MP0003943_abnormal_hepatobiliary_system0.70945187
117MP0002161_abnormal_fertility/fecundity0.70800346
118MP0008260_abnormal_autophagy0.69875742
119MP0001853_heart_inflammation0.68811760
120MP0003656_abnormal_erythrocyte_physiolo0.68428794
121MP0003567_abnormal_fetal_cardiomyocyte0.68306773
122MP0005023_abnormal_wound_healing0.68234052
123MP0000428_abnormal_craniofacial_morphol0.67592905
124MP0004147_increased_porphyrin_level0.67346807
125MP0009672_abnormal_birth_weight0.66375121
126MP0000358_abnormal_cell_content/0.66349961
127MP0002148_abnormal_hypersensitivity_rea0.63993200
128MP0000678_abnormal_parathyroid_gland0.63691418
129MP0003950_abnormal_plasma_membrane0.62835164
130MP0003698_abnormal_male_reproductive0.62500770
131MP0003315_abnormal_perineum_morphology0.62371677
132MP0000015_abnormal_ear_pigmentation0.60769781
133MP0002796_impaired_skin_barrier0.58862093
134MP0001529_abnormal_vocalization0.55598667
135MP0003453_abnormal_keratinocyte_physiol0.54678537
136MP0000566_synostosis0.53820809
137MP0002234_abnormal_pharynx_morphology0.48761957
138MP0003861_abnormal_nervous_system0.48002498
139MP0000372_irregular_coat_pigmentation0.47693746

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.41095541
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.86244317
3Chromsome breakage (HP:0040012)4.79693703
4Breast hypoplasia (HP:0003187)4.28581645
5Abnormality of chromosome stability (HP:0003220)3.67718462
6Meckel diverticulum (HP:0002245)3.63553093
7Reticulocytopenia (HP:0001896)3.61694432
8Carpal bone hypoplasia (HP:0001498)3.54216451
9Abnormality of the preputium (HP:0100587)3.50874872
10Patellar aplasia (HP:0006443)3.50190891
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.45171531
12Abnormality of the ileum (HP:0001549)3.40575473
13Nephroblastoma (Wilms tumor) (HP:0002667)3.37454663
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.33242551
15Cerebral hypomyelination (HP:0006808)3.31776799
16Agnosia (HP:0010524)3.23760985
17Aplasia/Hypoplasia of the patella (HP:0006498)3.22129724
18Myelodysplasia (HP:0002863)3.21054926
19Duodenal stenosis (HP:0100867)3.16372415
20Small intestinal stenosis (HP:0012848)3.16372415
21Embryonal renal neoplasm (HP:0011794)3.16182557
22Abnormality of reticulocytes (HP:0004312)3.07875424
23Oral leukoplakia (HP:0002745)2.99844152
24Colon cancer (HP:0003003)2.88801388
25Bone marrow hypocellularity (HP:0005528)2.84099453
26Premature ovarian failure (HP:0008209)2.79949041
27Rough bone trabeculation (HP:0100670)2.79633447
28Rhabdomyosarcoma (HP:0002859)2.77140443
29Impulsivity (HP:0100710)2.74886436
30Macrocytic anemia (HP:0001972)2.73806233
31Degeneration of anterior horn cells (HP:0002398)2.70767721
32Abnormality of the anterior horn cell (HP:0006802)2.70767721
33Abnormal gallbladder physiology (HP:0012438)2.69963931
34Cholecystitis (HP:0001082)2.69963931
35Overlapping toe (HP:0001845)2.69166879
36Absent radius (HP:0003974)2.67307442
37Aplastic anemia (HP:0001915)2.67085273
38Thrombocytosis (HP:0001894)2.66878034
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.61038426
40Facial hemangioma (HP:0000329)2.58852875
41Duplicated collecting system (HP:0000081)2.57862466
42Sloping forehead (HP:0000340)2.54953496
43Aplasia involving forearm bones (HP:0009822)2.54254632
44Absent forearm bone (HP:0003953)2.54254632
45Volvulus (HP:0002580)2.52505050
46Progressive muscle weakness (HP:0003323)2.49603751
47Abnormality of the duodenum (HP:0002246)2.47353291
48Progressive external ophthalmoplegia (HP:0000590)2.47294241
49Medulloblastoma (HP:0002885)2.46545318
50Microvesicular hepatic steatosis (HP:0001414)2.45580367
51Duplication of thumb phalanx (HP:0009942)2.45578706
52Abnormal number of erythroid precursors (HP:0012131)2.45448610
53Secondary amenorrhea (HP:0000869)2.41534961
54Clubbing of toes (HP:0100760)2.41176267
55Abnormality of the renal collecting system (HP:0004742)2.39799224
56Abnormality of the labia minora (HP:0012880)2.38411865
57Abnormality of cells of the erythroid lineage (HP:0012130)2.37443493
58Increased serum pyruvate (HP:0003542)2.36412959
59Abnormality of glycolysis (HP:0004366)2.36221464
60Abnormality of the carotid arteries (HP:0005344)2.35154733
61Ectopic kidney (HP:0000086)2.34093997
62Absent thumb (HP:0009777)2.31416650
63Cafe-au-lait spot (HP:0000957)2.30499145
64Slender long bone (HP:0003100)2.28847820
65Ureteral duplication (HP:0000073)2.28317514
66Squamous cell carcinoma (HP:0002860)2.27971733
67Reticulocytosis (HP:0001923)2.19372888
68Abnormality of lateral ventricle (HP:0030047)2.18697040
69Embryonal neoplasm (HP:0002898)2.17830092
70Triphalangeal thumb (HP:0001199)2.17194308
71Recurrent abscess formation (HP:0002722)2.14590204
72Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12097470
73Increased hepatocellular lipid droplets (HP:0006565)2.12079423
74Choanal atresia (HP:0000453)2.11239866
75Abnormality of cochlea (HP:0000375)2.10522853
76Selective tooth agenesis (HP:0001592)2.08254915
77Tracheoesophageal fistula (HP:0002575)2.08212718
78Increased nuchal translucency (HP:0010880)2.04976145
79Leukopenia (HP:0001882)2.04531177
80Recurrent bacterial skin infections (HP:0005406)2.04416571
81Neoplasm of the pancreas (HP:0002894)2.03965121
82Prominent nose (HP:0000448)2.03181061
83Neoplasm of the colon (HP:0100273)2.02927536
84Microretrognathia (HP:0000308)2.02319883
85Type I transferrin isoform profile (HP:0003642)2.01522644
86Missing ribs (HP:0000921)2.01056871
87Homocystinuria (HP:0002156)2.00532568
88Abnormality of homocysteine metabolism (HP:0010919)2.00532568
89Ependymoma (HP:0002888)2.00417356
90Amaurosis fugax (HP:0100576)1.98449198
91Deep philtrum (HP:0002002)1.98013543
9211 pairs of ribs (HP:0000878)1.97226574
93Abnormality of pyrimidine metabolism (HP:0004353)1.96989486
94Premature graying of hair (HP:0002216)1.96874226
95High pitched voice (HP:0001620)1.96263047
96Abnormal trabecular bone morphology (HP:0100671)1.94002033
97Abnormal number of incisors (HP:0011064)1.93433405
98Horseshoe kidney (HP:0000085)1.93203527
99Pancytopenia (HP:0001876)1.93055499
100Reduced antithrombin III activity (HP:0001976)1.91498490
101Abnormality of chromosome segregation (HP:0002916)1.88850839
102Pulmonary fibrosis (HP:0002206)1.88353765
103Cortical dysplasia (HP:0002539)1.87148015
104Small epiphyses (HP:0010585)1.86767617
105Acute necrotizing encephalopathy (HP:0006965)1.85891450
106Abnormality of DNA repair (HP:0003254)1.85364391
107Capillary hemangiomas (HP:0005306)1.84004691
108Arteriovenous malformation (HP:0100026)1.83422572
109Lipid accumulation in hepatocytes (HP:0006561)1.83375392
110Lymphoma (HP:0002665)1.83196696
111Personality changes (HP:0000751)1.82726755
112Abnormal mitochondria in muscle tissue (HP:0008316)1.82438270
113Abnormal glycosylation (HP:0012345)1.82088533
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82088533
115Abnormal protein N-linked glycosylation (HP:0012347)1.82088533
116Abnormal protein glycosylation (HP:0012346)1.82088533
117Abnormality of the septum pellucidum (HP:0007375)1.82013360
118Neoplasm of striated muscle (HP:0009728)1.81143838
119Abnormality of the fingertips (HP:0001211)1.80981690
120Breast aplasia (HP:0100783)1.80687622
121Atresia of the external auditory canal (HP:0000413)1.80142718
122Acute encephalopathy (HP:0006846)1.79631925
123Absent septum pellucidum (HP:0001331)1.79398383
124Pallor (HP:0000980)1.78034182
125Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76449406
126Short middle phalanx of the 5th finger (HP:0004220)1.75841646
127Deviation of the thumb (HP:0009603)1.74839786
128Hypergonadotropic hypogonadism (HP:0000815)1.74177066
129Combined immunodeficiency (HP:0005387)1.74097287
130Short thumb (HP:0009778)1.73794695
131Supernumerary spleens (HP:0009799)1.72544637
132Acute myeloid leukemia (HP:0004808)1.72035916
133Abnormal lung lobation (HP:0002101)1.71258068
134Aplasia/Hypoplasia of the breasts (HP:0010311)1.71063867
135Hypoplasia of the pons (HP:0012110)1.70561672
136Multiple enchondromatosis (HP:0005701)1.69743375
137Abnormality of the pons (HP:0007361)1.69048544
138Proximal placement of thumb (HP:0009623)1.69002356
139Cellular immunodeficiency (HP:0005374)1.68577323
140CNS hypomyelination (HP:0003429)1.68165265
141Morphological abnormality of the inner ear (HP:0011390)1.61492640
142Septate vagina (HP:0001153)1.61485197
143Respiratory difficulties (HP:0002880)1.61464860
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.60618625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.37142535
2WEE14.44011392
3CDC73.62178643
4STK103.29333537
5BRSK23.24593074
6NEK23.21681952
7TTK2.65155009
8ACVR1B2.44917998
9VRK22.40505124
10PLK42.40010739
11EIF2AK12.03753133
12PLK12.01539296
13CDK121.99903372
14DYRK31.93126001
15BRSK11.90591438
16MAP3K101.89731848
17MAP3K81.88783754
18SRPK11.76040230
19RPS6KA41.66948979
20AURKB1.64734872
21EIF2AK31.64210377
22TESK21.58526106
23NEK11.58338120
24CDK41.55734035
25STK41.51508327
26FLT31.44343036
27CHEK21.41946548
28CLK11.40794328
29TAF11.36743932
30NME21.35340184
31PIM21.30179380
32CDK71.29395815
33VRK11.26490918
34PLK31.25078259
35MELK1.23407805
36BRAF1.21445884
37ATR1.20155285
38SMG11.19191280
39AURKA1.18432346
40TLK11.18268089
41EEF2K1.15591545
42LATS21.12370718
43PNCK1.10808684
44MAP4K11.10172430
45NME11.09359206
46STK31.08967956
47ARAF1.08807640
48MKNK21.07745227
49CDK81.07682216
50TAOK31.05195161
51MOS1.04901743
52RPS6KB21.02893497
53MKNK11.01544282
54PIM10.98267949
55LRRK20.90604832
56CHEK10.90542171
57BRD40.90110652
58MST40.84314789
59CCNB10.84152530
60MAPKAPK30.83151764
61PKN20.79139672
62PDK20.78298895
63TSSK60.78277743
64PAK10.76866803
65MAP3K50.75357183
66MAP3K60.74987229
67RAF10.74866205
68ZAP700.74286927
69CDK60.71855623
70JAK30.65965006
71BMPR20.65860379
72PAK40.65636821
73CDK20.64547386
74CSF1R0.62606035
75ATM0.60692765
76ZAK0.59738226
77NLK0.59590737
78KIT0.54653592
79TGFBR10.53194905
80STK160.52858577
81MARK30.52653373
82EIF2AK20.51632060
83BLK0.51174609
84CDK30.50662462
85PBK0.49455357
86TYK20.48787859
87CDK10.47999079
88LATS10.47702268
89TRIB30.47366610
90SCYL20.45597148
91CDK90.45124277
92ICK0.44016439
93TEC0.43142818
94KSR20.42707359
95CDK11A0.42336049
96CDK150.39435194
97RPS6KA50.38966021
98ALK0.38294823
99CDK180.36977467
100BMX0.35902490
101BTK0.34998703
102MAP3K110.34810594
103NUAK10.34337902
104RIPK40.34323478
105IRAK30.33901628
106CSNK2A10.33708851
107TNIK0.32925622
108CDK140.32302875
109MAP2K30.31932280
110NEK90.30585663
111DMPK0.30306690
112ERBB40.30122211
113CSNK1E0.29816659
114DYRK20.29668852
115MAP3K90.29654830
116MAPKAPK20.29105461
117TRIM280.28830369
118TAOK20.28402341
119EPHA20.27589204
120AKT20.27271967
121STK38L0.26609300
122ABL20.26322171
123CSNK2A20.25753761
124IRAK40.25202472
125MAP3K140.24997547
126PASK0.24955618
127PRKDC0.23825282
128STK240.22854575
129MAPKAPK50.22565257
130MTOR0.22493840
131MAPK140.21727123
132KSR10.18928368
133MST1R0.18214105

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.76458503
2Mismatch repair_Homo sapiens_hsa034303.64842361
3Cell cycle_Homo sapiens_hsa041103.41072963
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24100647
5Base excision repair_Homo sapiens_hsa034103.22136870
6RNA polymerase_Homo sapiens_hsa030203.19414155
7Homologous recombination_Homo sapiens_hsa034403.02142814
8RNA transport_Homo sapiens_hsa030132.96372396
9Spliceosome_Homo sapiens_hsa030402.70737964
10Fanconi anemia pathway_Homo sapiens_hsa034602.59204644
11Nucleotide excision repair_Homo sapiens_hsa034202.57306355
12One carbon pool by folate_Homo sapiens_hsa006702.54612814
13Proteasome_Homo sapiens_hsa030502.32787264
14Pyrimidine metabolism_Homo sapiens_hsa002402.31028656
15Basal transcription factors_Homo sapiens_hsa030222.30804438
16Non-homologous end-joining_Homo sapiens_hsa034502.02150252
17Ribosome_Homo sapiens_hsa030101.98044756
18RNA degradation_Homo sapiens_hsa030181.93426237
19p53 signaling pathway_Homo sapiens_hsa041151.77915830
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68806828
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51266104
22mRNA surveillance pathway_Homo sapiens_hsa030151.48030866
23Vitamin B6 metabolism_Homo sapiens_hsa007501.42758864
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38973072
25Folate biosynthesis_Homo sapiens_hsa007901.37671849
26Epstein-Barr virus infection_Homo sapiens_hsa051691.28337274
27Herpes simplex infection_Homo sapiens_hsa051681.27959477
28Oocyte meiosis_Homo sapiens_hsa041141.25208345
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24242736
30Antigen processing and presentation_Homo sapiens_hsa046121.18989735
31Systemic lupus erythematosus_Homo sapiens_hsa053221.12350120
32Pyruvate metabolism_Homo sapiens_hsa006201.11442474
33Parkinsons disease_Homo sapiens_hsa050121.10878996
34Oxidative phosphorylation_Homo sapiens_hsa001901.09549851
35Huntingtons disease_Homo sapiens_hsa050161.09489443
36Purine metabolism_Homo sapiens_hsa002301.06933754
37Viral carcinogenesis_Homo sapiens_hsa052031.04626471
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96327791
39Carbon metabolism_Homo sapiens_hsa012000.92328783
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91272321
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88506343
42Apoptosis_Homo sapiens_hsa042100.86776695
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86682488
44Pentose phosphate pathway_Homo sapiens_hsa000300.86485614
45Legionellosis_Homo sapiens_hsa051340.83915983
46HTLV-I infection_Homo sapiens_hsa051660.83723050
47Sulfur relay system_Homo sapiens_hsa041220.82961374
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79772765
49Steroid biosynthesis_Homo sapiens_hsa001000.79763634
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78513966
51Hepatitis B_Homo sapiens_hsa051610.77604156
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.75511007
53Selenocompound metabolism_Homo sapiens_hsa004500.73961412
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.73521088
55MicroRNAs in cancer_Homo sapiens_hsa052060.73407324
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.72415749
57Measles_Homo sapiens_hsa051620.69747361
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.69233705
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68535819
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67175486
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65062425
62Small cell lung cancer_Homo sapiens_hsa052220.64506655
63Colorectal cancer_Homo sapiens_hsa052100.62839011
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60938179
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59085931
66Pancreatic cancer_Homo sapiens_hsa052120.58714293
67Biosynthesis of amino acids_Homo sapiens_hsa012300.58458919
68Leishmaniasis_Homo sapiens_hsa051400.57771267
69Chronic myeloid leukemia_Homo sapiens_hsa052200.55193331
70Primary immunodeficiency_Homo sapiens_hsa053400.55094742
71Fructose and mannose metabolism_Homo sapiens_hsa000510.54847780
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.54540382
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52752139
74N-Glycan biosynthesis_Homo sapiens_hsa005100.51175558
75Influenza A_Homo sapiens_hsa051640.51096445
76Thyroid cancer_Homo sapiens_hsa052160.49071627
77Shigellosis_Homo sapiens_hsa051310.49069987
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48540991
79Alzheimers disease_Homo sapiens_hsa050100.48038435
80Graft-versus-host disease_Homo sapiens_hsa053320.44631807
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44314042
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43640680
83Alcoholism_Homo sapiens_hsa050340.42282966
84Hematopoietic cell lineage_Homo sapiens_hsa046400.41716760
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41578747
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40596769
87TGF-beta signaling pathway_Homo sapiens_hsa043500.38915235
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38866563
89Lysine degradation_Homo sapiens_hsa003100.38388224
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37564006
91Regulation of autophagy_Homo sapiens_hsa041400.37466875
92Notch signaling pathway_Homo sapiens_hsa043300.36479407
93B cell receptor signaling pathway_Homo sapiens_hsa046620.36445262
94Malaria_Homo sapiens_hsa051440.35407057
95mTOR signaling pathway_Homo sapiens_hsa041500.33593242
96Protein export_Homo sapiens_hsa030600.33262637
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31920164
98Tuberculosis_Homo sapiens_hsa051520.31343970
99Glutathione metabolism_Homo sapiens_hsa004800.30579735
100Fatty acid elongation_Homo sapiens_hsa000620.30263776
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.30022692
102Metabolic pathways_Homo sapiens_hsa011000.29799573
103Acute myeloid leukemia_Homo sapiens_hsa052210.29279744
104Osteoclast differentiation_Homo sapiens_hsa043800.29074235
105FoxO signaling pathway_Homo sapiens_hsa040680.28346953
106TNF signaling pathway_Homo sapiens_hsa046680.26129179
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.25035571
108Propanoate metabolism_Homo sapiens_hsa006400.24354764
109Pertussis_Homo sapiens_hsa051330.24062195
110Other glycan degradation_Homo sapiens_hsa005110.23989832
111Bladder cancer_Homo sapiens_hsa052190.22753443
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.22662928
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21770572
114Non-small cell lung cancer_Homo sapiens_hsa052230.20254150
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19950258
116HIF-1 signaling pathway_Homo sapiens_hsa040660.19349363
117Toxoplasmosis_Homo sapiens_hsa051450.19224604
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18928570
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18849809
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18589649
121Galactose metabolism_Homo sapiens_hsa000520.17928401
122Asthma_Homo sapiens_hsa053100.16919063
123Prostate cancer_Homo sapiens_hsa052150.16847906
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15997394
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15632320
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14393698
127Adherens junction_Homo sapiens_hsa045200.13765598
128Wnt signaling pathway_Homo sapiens_hsa043100.13649159
129Basal cell carcinoma_Homo sapiens_hsa052170.13643261
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13392099
131Renal cell carcinoma_Homo sapiens_hsa052110.12474116
132Hippo signaling pathway_Homo sapiens_hsa043900.10613236
133Melanoma_Homo sapiens_hsa052180.08730689

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