FAM71B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.99681218
2cell-cell recognition (GO:0009988)9.91893923
3plasma membrane fusion (GO:0045026)9.71913683
4epithelial cilium movement (GO:0003351)9.57960525
5response to pheromone (GO:0019236)9.47462860
6axonemal dynein complex assembly (GO:0070286)9.41297553
7spermatid development (GO:0007286)9.40701810
8motile cilium assembly (GO:0044458)9.09190198
9reproduction (GO:0000003)9.05270570
10cilium or flagellum-dependent cell motility (GO:0001539)9.00091014
11regulation of cilium movement (GO:0003352)8.53657214
12cilium movement (GO:0003341)7.65886806
13negative regulation of inclusion body assembly (GO:0090084)7.15598229
14rRNA methylation (GO:0031167)7.09315346
15single fertilization (GO:0007338)7.07253495
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.04919869
17sperm capacitation (GO:0048240)7.00113551
18synaptonemal complex organization (GO:0070193)6.60845161
19protein targeting to Golgi (GO:0000042)6.52146652
20male meiosis (GO:0007140)6.47967930
21synaptonemal complex assembly (GO:0007130)6.38117249
22spermatogenesis (GO:0007283)6.36734216
23male gamete generation (GO:0048232)6.34493162
24piRNA metabolic process (GO:0034587)6.31401560
25establishment of protein localization to Golgi (GO:0072600)6.27126980
26phosphatidylethanolamine biosynthetic process (GO:0006646)6.25402816
27microtubule depolymerization (GO:0007019)6.16051581
28retrograde transport, vesicle recycling within Golgi (GO:0000301)6.06917466
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.99846910
30fertilization (GO:0009566)5.97859835
31rRNA modification (GO:0000154)5.96278610
32organic cation transport (GO:0015695)5.94679822
33gamete generation (GO:0007276)5.83130391
34cellular ketone body metabolic process (GO:0046950)5.79006909
35phosphatidylethanolamine metabolic process (GO:0046337)5.76737096
36regulation of inclusion body assembly (GO:0090083)5.75327455
37centriole replication (GO:0007099)5.36734325
38germ cell development (GO:0007281)5.19955110
39calcium ion-dependent exocytosis (GO:0017156)5.15863572
40chromosome condensation (GO:0030261)5.13873934
41cellular process involved in reproduction in multicellular organism (GO:0022412)5.12144196
42regulation of Rab GTPase activity (GO:0032313)5.12003324
43positive regulation of Rab GTPase activity (GO:0032851)5.12003324
44ketone body metabolic process (GO:1902224)5.11057088
45ventricular system development (GO:0021591)5.00328811
46spermatid nucleus differentiation (GO:0007289)4.97831104
47regulation of microtubule-based movement (GO:0060632)4.86682624
48DNA packaging (GO:0006323)4.85730532
49cell recognition (GO:0008037)4.72618216
50protein localization to Golgi apparatus (GO:0034067)4.71361598
51glycerol ether metabolic process (GO:0006662)4.70337819
52multicellular organismal reproductive process (GO:0048609)4.59500665
53male meiosis I (GO:0007141)4.59466965
54sexual reproduction (GO:0019953)4.53128446
55regulation of transcription involved in cell fate commitment (GO:0060850)4.42658350
56chromosome organization involved in meiosis (GO:0070192)4.38685053
57regulation of centriole replication (GO:0046599)4.38216017
58ether metabolic process (GO:0018904)4.33053693
59seminiferous tubule development (GO:0072520)4.31651573
60microtubule severing (GO:0051013)4.16208011
61left/right pattern formation (GO:0060972)4.07206951
62coenzyme catabolic process (GO:0009109)4.02723256
63single strand break repair (GO:0000012)3.99821885
64meiotic nuclear division (GO:0007126)3.99359200
65DNA methylation involved in gamete generation (GO:0043046)3.96184556
66negative regulation of Rho protein signal transduction (GO:0035024)3.95493514
67chaperone-mediated protein complex assembly (GO:0051131)3.84207059
68sequestering of actin monomers (GO:0042989)3.78913782
69genitalia morphogenesis (GO:0035112)3.71979297
70monoubiquitinated protein deubiquitination (GO:0035520)3.69550608
71meiosis I (GO:0007127)3.68446190
72multicellular organismal development (GO:0007275)3.65452850
73multicellular organismal movement (GO:0050879)3.62570961
74musculoskeletal movement (GO:0050881)3.62570961
75glomerular visceral epithelial cell development (GO:0072015)3.56784395
76negative regulation of gene expression, epigenetic (GO:0045814)3.52051308
77glomerular epithelial cell development (GO:0072310)3.43931491
78protein-DNA complex disassembly (GO:0032986)3.39978170
79nucleosome disassembly (GO:0006337)3.39978170
80nucleus organization (GO:0006997)3.39641846
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.38434808
82protein refolding (GO:0042026)3.38215725
83protein K11-linked deubiquitination (GO:0035871)3.37450452
84mitotic sister chromatid cohesion (GO:0007064)3.35362492
85response to acidic pH (GO:0010447)3.27476821
86glycolytic process (GO:0006096)3.26469016
87regulation of interleukin-13 production (GO:0032656)3.25052186
88peptidyl-threonine dephosphorylation (GO:0035970)3.23800548
89cerebral cortex neuron differentiation (GO:0021895)3.18538271
90interferon-gamma secretion (GO:0072643)3.17214705
91meiotic cell cycle (GO:0051321)3.16699789
92mesenchymal cell differentiation involved in kidney development (GO:0072161)3.16565640
93mesenchymal cell differentiation involved in renal system development (GO:2001012)3.16565640
94protein polyglutamylation (GO:0018095)3.15882459
95histone H3-K9 demethylation (GO:0033169)3.15080526
96cellular response to pH (GO:0071467)3.14793299
97protein depolymerization (GO:0051261)3.14555633
98regulation of T-helper 2 cell differentiation (GO:0045628)3.13795495
99regulation of spindle checkpoint (GO:0090231)3.13610944
100microtubule nucleation (GO:0007020)3.12384502
101cell differentiation involved in metanephros development (GO:0072202)3.11325758
102RNA localization (GO:0006403)3.08124763
103microtubule polymerization or depolymerization (GO:0031109)3.04587290
104homeostasis of number of cells within a tissue (GO:0048873)3.04494894
105DNA conformation change (GO:0071103)3.02790784
106cranial nerve morphogenesis (GO:0021602)2.96635318
107lactate metabolic process (GO:0006089)2.94762868
108nuclear pore complex assembly (GO:0051292)2.94276142
109RNA destabilization (GO:0050779)2.85936300
110NAD biosynthetic process (GO:0009435)2.84662531
111chromatin silencing (GO:0006342)2.81830133
112receptor recycling (GO:0001881)2.74922600
113regulation of ARF GTPase activity (GO:0032312)2.70886996
114meiotic cell cycle process (GO:1903046)2.70130949
115regulation of phosphoprotein phosphatase activity (GO:0043666)2.68760377
116negative regulation of histone methylation (GO:0031061)2.68275735
117gene silencing by RNA (GO:0031047)2.67501660
118regulation of somitogenesis (GO:0014807)2.66364456
119polyol catabolic process (GO:0046174)2.65663149
120amino-acid betaine transport (GO:0015838)2.65585022
121carnitine transport (GO:0015879)2.65585022
122protein localization to cilium (GO:0061512)2.65479391
123negative regulation of organelle assembly (GO:1902116)2.59355688
124gene silencing (GO:0016458)2.58904515
125activated T cell proliferation (GO:0050798)2.56291582
126regulation of cilium assembly (GO:1902017)2.55968717
127microtubule-based movement (GO:0007018)2.54838062
128negative regulation of skeletal muscle tissue development (GO:0048642)2.53732434
129membrane protein intracellular domain proteolysis (GO:0031293)2.52813011
130cilium organization (GO:0044782)2.51562291
131carnitine transmembrane transport (GO:1902603)2.47960669
132protein localization to chromosome, centromeric region (GO:0071459)2.47453233
133nucleoside diphosphate phosphorylation (GO:0006165)2.46840677
134polyamine biosynthetic process (GO:0006596)2.46315071
135centriole assembly (GO:0098534)2.45566558
136positive regulation of glycolytic process (GO:0045821)2.44591051
137positive regulation of macrophage activation (GO:0043032)2.43344462
138synapsis (GO:0007129)2.43250126
139alditol metabolic process (GO:0019400)2.39646146
140cilium assembly (GO:0042384)2.39475500
141sperm motility (GO:0030317)13.7514652
142fusion of sperm to egg plasma membrane (GO:0007342)12.7511230
143cell wall macromolecule catabolic process (GO:0016998)11.8308295
144cell wall macromolecule metabolic process (GO:0044036)11.8308295
145acrosome reaction (GO:0007340)11.7183096
146sperm-egg recognition (GO:0035036)10.9610449
147acrosome assembly (GO:0001675)10.3704377
148multicellular organism reproduction (GO:0032504)10.3445403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.35081328
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.56910984
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.07726736
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.72749793
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.25681097
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.21527706
7EZH2_22144423_ChIP-Seq_EOC_Human2.95169597
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.91594994
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.89807478
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.48717997
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.43875050
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19000586
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16762947
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.12866612
15VDR_22108803_ChIP-Seq_LS180_Human2.07924788
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.06178171
17ERA_21632823_ChIP-Seq_H3396_Human2.01051288
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00526913
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98058894
20RAC3_21632823_ChIP-Seq_H3396_Human1.93317192
21DROSHA_22980978_ChIP-Seq_HELA_Human1.93144575
22FUS_26573619_Chip-Seq_HEK293_Human1.92302773
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.91998671
24FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88204903
25RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.83161780
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.80850525
27NANOG_20526341_ChIP-Seq_ESCs_Human1.79853648
28CTCF_27219007_Chip-Seq_Bcells_Human1.79017581
29EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.78912734
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73480494
31BCL6_27268052_Chip-Seq_Bcells_Human1.70768669
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67956251
33WDR5_24793694_ChIP-Seq_LNCAP_Human1.67921419
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.64962678
35E2F1_20622854_ChIP-Seq_HELA_Human1.63185857
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.61997858
37TAF2_19829295_ChIP-Seq_ESCs_Human1.60967122
38SMC4_20622854_ChIP-Seq_HELA_Human1.59758718
39GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.59370311
40MYC_19829295_ChIP-Seq_ESCs_Human1.59103613
41ER_23166858_ChIP-Seq_MCF-7_Human1.58796073
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57685968
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.56761072
44SMAD4_21741376_ChIP-Seq_EPCs_Human1.52570326
45* STAT1_17558387_ChIP-Seq_HELA_Human1.52418955
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.51907486
47P68_20966046_ChIP-Seq_HELA_Human1.51266495
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51014929
49KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.48521922
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.48012597
51SOX2_22085726_ChIP-Seq_NPCs_Mouse1.47051169
52TP63_22573176_ChIP-Seq_HFKS_Human1.46306175
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.43387905
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43076016
55AR_25329375_ChIP-Seq_VCAP_Human1.42091887
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41628394
57TP53_18474530_ChIP-ChIP_U2OS_Human1.41300533
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40380117
59FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39669004
60LXR_22292898_ChIP-Seq_THP-1_Human1.39524734
61MYB_26560356_Chip-Seq_TH2_Human1.39260160
62GATA3_21867929_ChIP-Seq_CD8_Mouse1.39053085
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38594145
64CBP_20019798_ChIP-Seq_JUKART_Human1.38397668
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38397668
66LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.37745498
67* OCT4_20526341_ChIP-Seq_ESCs_Human1.36585182
68HNFA_21074721_ChIP-Seq_CACO-2_Human1.36224434
69ZNF274_21170338_ChIP-Seq_K562_Hela1.36219702
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35941635
71CBX2_22325352_ChIP-Seq_293T-Rex_Human1.35743292
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34748050
73KDM2B_26808549_Chip-Seq_REH_Human1.33667495
74P300_27268052_Chip-Seq_Bcells_Human1.33024079
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31684039
76SMAD3_21741376_ChIP-Seq_ESCs_Human1.31655737
77RBPJ_21746931_ChIP-Seq_IB4_Human1.31387553
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30991309
79RUNX_20019798_ChIP-Seq_JUKART_Human1.30725655
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29891748
81SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29598829
82CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28517360
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.28311150
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28258505
85P53_21459846_ChIP-Seq_SAOS-2_Human1.28159173
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.27053468
87ETV1_20927104_ChIP-Seq_GIST48_Human1.26372058
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25106367
89CEBPB_22108803_ChIP-Seq_LS180_Human1.24129021
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22561243
91P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.22070083
92GATA3_21867929_ChIP-Seq_TH1_Mouse1.21921067
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21042937
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.20860275
95P300_19829295_ChIP-Seq_ESCs_Human1.20240671
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19281629
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18287856
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18249595
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.16867626
100SMAD4_21741376_ChIP-Seq_HESCs_Human1.15753424
101* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15713638
102GATA1_19941827_ChIP-Seq_MEL86_Mouse1.14979455
103TBL1_22424771_ChIP-Seq_293T_Human1.13720418
104MYB_26560356_Chip-Seq_TH1_Human1.13395248
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13331648
106SMRT_27268052_Chip-Seq_Bcells_Human1.13192048
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13017176
108ELF1_20517297_ChIP-Seq_JURKAT_Human1.12225826
109SA1_27219007_Chip-Seq_Bcells_Human1.12208013
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11933777
111GF1_26923725_Chip-Seq_HPCs_Mouse1.11813165
112KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11616897
113SPI1_26923725_Chip-Seq_HPCs_Mouse1.11417186
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11334865
115SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10620357
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.09841848
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.09702740
118PHF8_20622853_ChIP-Seq_HELA_Human1.09567679
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08150617
120EZH2_27294783_Chip-Seq_ESCs_Mouse1.08060772
121* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07264332
122PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07130297
123RUNX2_22187159_ChIP-Seq_PCA_Human1.06044591
124GATA6_21074721_ChIP-Seq_CACO-2_Human1.05866899
125CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05270209
126* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05047678
127EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04619636
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03927907
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03927907
130RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03254925
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02971446
132* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02259244
133NANOG_19829295_ChIP-Seq_ESCs_Human1.01998433
134SOX2_19829295_ChIP-Seq_ESCs_Human1.01998433
135* FLI1_21867929_ChIP-Seq_CD8_Mouse1.01507893
136HOXB7_26014856_ChIP-Seq_BT474_Human1.01494070
137STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01226937
138RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00230113
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00227548
140E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00072482
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99474263
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99158039
143NFYA_21822215_ChIP-Seq_K562_Human0.99006655
144OCT1_27270436_Chip-Seq_PROSTATE_Human0.98685370
145ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98644101
146PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98541066
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98370901
148MYC_27129775_Chip-Seq_CORNEA_Mouse0.98315601
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98253701
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97105604
151SA1_27219007_Chip-Seq_ERYTHROID_Human0.96452882
152KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96199817
153GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96143049
154RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95749687
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95614698
156REST_21632747_ChIP-Seq_MESCs_Mouse0.95454628
157ERG_20517297_ChIP-Seq_VCAP_Human0.95051955
158CTCF_20526341_ChIP-Seq_ESCs_Human0.94676798
159SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.94665090
160TCF7_22412390_ChIP-Seq_EML_Mouse0.94242965
161SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93754623
162BCOR_27268052_Chip-Seq_Bcells_Human0.93718394
163TET1_21451524_ChIP-Seq_MESCs_Mouse0.93599188
164RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93422871
165SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93284770
166TAF15_26573619_Chip-Seq_HEK293_Human0.93101381
167PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92755702
168YY1_22570637_ChIP-Seq_MALME-3M_Human0.91897211
169CRX_20693478_ChIP-Seq_RETINA_Mouse0.91847557
170JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91302995
171CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89715197
172PHF8_20622854_ChIP-Seq_HELA_Human0.89554644
173GATA3_27048872_Chip-Seq_THYMUS_Human0.89417271
174NFYB_21822215_ChIP-Seq_K562_Human0.88850078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.62714933
2MP0001929_abnormal_gametogenesis5.14757315
3MP0001348_abnormal_lacrimal_gland3.87044704
4MP0008877_abnormal_DNA_methylation3.85757835
5MP0002210_abnormal_sex_determination3.06863820
6MP0002161_abnormal_fertility/fecundity3.05245312
7MP0005670_abnormal_white_adipose2.81725427
8MP0000678_abnormal_parathyroid_gland2.70571848
9MP0001145_abnormal_male_reproductive2.59782058
10MP0000653_abnormal_sex_gland2.22006601
11MP0003718_maternal_effect2.12094319
12MP0005410_abnormal_fertilization15.5834005
13MP0005379_endocrine/exocrine_gland_phen1.82182522
14MP0002653_abnormal_ependyma_morphology1.81830323
15MP0004510_myositis1.71066450
16MP0003763_abnormal_thymus_physiology1.64732076
17MP0005423_abnormal_somatic_nervous1.60996261
18MP0002249_abnormal_larynx_morphology1.60702237
19MP0001485_abnormal_pinna_reflex1.52883439
20MP0001486_abnormal_startle_reflex1.52407279
21MP0009053_abnormal_anal_canal1.43102304
22MP0005310_abnormal_salivary_gland1.38745813
23MP0002138_abnormal_hepatobiliary_system1.33645125
24MP0001765_abnormal_ion_homeostasis1.26467916
25MP0000685_abnormal_immune_system1.26049503
26MP0002735_abnormal_chemical_nociception1.24936456
27MP0005671_abnormal_response_to1.22418529
28MP0000534_abnormal_ureter_morphology1.22082188
29MP0004742_abnormal_vestibular_system1.21846967
30MP0002160_abnormal_reproductive_system1.20365183
31MP0002405_respiratory_system_inflammati1.20246927
32MP0004859_abnormal_synaptic_plasticity1.15279236
33MP0005623_abnormal_meninges_morphology1.10627398
34MP0002127_abnormal_cardiovascular_syste1.10115229
35MP0001968_abnormal_touch/_nociception1.09639784
36MP0005248_abnormal_Harderian_gland1.09260063
37MP0001963_abnormal_hearing_physiology1.08270945
38MP0002282_abnormal_trachea_morphology1.04877565
39MP0003879_abnormal_hair_cell1.04010241
40MP0003436_decreased_susceptibility_to1.03728097
41MP0005395_other_phenotype0.99117668
42MP0009278_abnormal_bone_marrow0.97427869
43MP0005397_hematopoietic_system_phenotyp0.96560484
44MP0001545_abnormal_hematopoietic_system0.96560484
45MP0002398_abnormal_bone_marrow0.96138256
46MP0005451_abnormal_body_composition0.95842230
47MP0004233_abnormal_muscle_weight0.95681294
48MP0000026_abnormal_inner_ear0.95312948
49MP0000703_abnormal_thymus_morphology0.94067107
50MP0003300_gastrointestinal_ulcer0.91343699
51MP0003646_muscle_fatigue0.89758813
52MP0004808_abnormal_hematopoietic_stem0.89162157
53MP0002723_abnormal_immune_serum0.88868575
54MP0000681_abnormal_thyroid_gland0.87906315
55MP0001835_abnormal_antigen_presentation0.87898418
56MP0001800_abnormal_humoral_immune0.87295734
57MP0009785_altered_susceptibility_to0.86222938
58MP0002229_neurodegeneration0.84782545
59MP0003866_abnormal_defecation0.81750839
60MP0008058_abnormal_DNA_repair0.81581882
61MP0000955_abnormal_spinal_cord0.80797653
62MP0002733_abnormal_thermal_nociception0.79397949
63MP0002420_abnormal_adaptive_immunity0.79336462
64MP0000516_abnormal_urinary_system0.78364622
65MP0005367_renal/urinary_system_phenotyp0.78364622
66MP0001819_abnormal_immune_cell0.78136562
67MP0000049_abnormal_middle_ear0.78015629
68MP0002132_abnormal_respiratory_system0.77491037
69MP0005551_abnormal_eye_electrophysiolog0.76867100
70MP0010094_abnormal_chromosome_stability0.76637448
71MP0002166_altered_tumor_susceptibility0.76334458
72MP0004085_abnormal_heartbeat0.75655561
73MP0006082_CNS_inflammation0.75371372
74MP0005636_abnormal_mineral_homeostasis0.73403459
75MP0000716_abnormal_immune_system0.72913684
76MP0001873_stomach_inflammation0.72399757
77MP0005025_abnormal_response_to0.72180300
78MP0005000_abnormal_immune_tolerance0.70891145
79MP0009333_abnormal_splenocyte_physiolog0.70762046
80MP0002067_abnormal_sensory_capabilities0.70145339
81MP0008569_lethality_at_weaning0.68587808
82MP0005647_abnormal_sex_gland0.68550650
83MP0001879_abnormal_lymphatic_vessel0.68292374
84MP0001790_abnormal_immune_system0.68167327
85MP0005387_immune_system_phenotype0.68167327
86MP0005083_abnormal_biliary_tract0.67048098
87MP0008961_abnormal_basal_metabolism0.66895252
88MP0002452_abnormal_antigen_presenting0.66776512
89MP0000689_abnormal_spleen_morphology0.65221610
90MP0005666_abnormal_adipose_tissue0.65175372
91MP0003115_abnormal_respiratory_system0.63163032
92MP0008995_early_reproductive_senescence0.63155780
93MP0002006_tumorigenesis0.62796084
94MP0005377_hearing/vestibular/ear_phenot0.62716470
95MP0003878_abnormal_ear_physiology0.62716470
96MP0005253_abnormal_eye_physiology0.62578168
97MP0002722_abnormal_immune_system0.62280720
98MP0005375_adipose_tissue_phenotype0.62082677
99MP0002557_abnormal_social/conspecific_i0.61601556
100MP0002429_abnormal_blood_cell0.59444438
101MP0003111_abnormal_nucleus_morphology0.59255372
102MP0001984_abnormal_olfaction0.58589766
103MP0000569_abnormal_digit_pigmentation0.58138041
104MP0005167_abnormal_blood-brain_barrier0.58120257
105MP0005389_reproductive_system_phenotype0.56819487
106MP0004484_altered_response_of0.56237806
107MP0003448_altered_tumor_morphology0.55959009
108MP0002572_abnormal_emotion/affect_behav0.54104025
109MP0000358_abnormal_cell_content/0.52919550
110MP0001666_abnormal_nutrient_absorption0.52687449
111MP0001905_abnormal_dopamine_level0.52677428
112MP0002928_abnormal_bile_duct0.51685693
113MP0001970_abnormal_pain_threshold0.51251582
114MP0008057_abnormal_DNA_replication0.51057201
115MP0000003_abnormal_adipose_tissue0.49810577
116MP0009115_abnormal_fat_cell0.49083887
117MP0001501_abnormal_sleep_pattern0.47291681
118MP0003137_abnormal_impulse_conducting0.47022446
119MP0003329_amyloid_beta_deposits0.46964970
120MP0009697_abnormal_copulation0.45642059
121MP0000858_altered_metastatic_potential0.45177424
122MP0005535_abnormal_body_temperature0.44977168
123MP0003699_abnormal_female_reproductive0.43495591
124MP0000604_amyloidosis0.43331075
125MP0002272_abnormal_nervous_system0.43199312
126MP0001845_abnormal_inflammatory_respons0.42982168
127MP0003119_abnormal_digestive_system0.42896010
128MP0009745_abnormal_behavioral_response0.42539374
129MP0002734_abnormal_mechanical_nocicepti0.42464580
130MP0005464_abnormal_platelet_physiology0.41554363
131MP0001440_abnormal_grooming_behavior0.41044056
132MP0006292_abnormal_olfactory_placode0.41031416
133MP0004947_skin_inflammation0.40890118
134MP0003077_abnormal_cell_cycle0.40348560
135MP0000470_abnormal_stomach_morphology0.39925142
136MP0003880_abnormal_central_pattern0.39843996
137MP0000249_abnormal_blood_vessel0.39550332
138MP0002971_abnormal_brown_adipose0.39386448
139MP0001764_abnormal_homeostasis0.39157861
140MP0002419_abnormal_innate_immunity0.38715214
141MP0004036_abnormal_muscle_relaxation0.38689046
142MP0010155_abnormal_intestine_physiology0.37912077
143MP0001851_eye_inflammation0.37851374
144MP0001730_embryonic_growth_arrest0.37681774
145MP0008469_abnormal_protein_level0.37290161
146MP0000230_abnormal_systemic_arterial0.36871973
147MP0002234_abnormal_pharynx_morphology0.36451043
148MP0000313_abnormal_cell_death0.35568165
149MP0003950_abnormal_plasma_membrane0.34774735
150MP0002822_catalepsy0.34572856
151MP0008007_abnormal_cellular_replicative0.34368619
152MP0003045_fibrosis0.34325597
153MP0003011_delayed_dark_adaptation0.33812769
154MP0003936_abnormal_reproductive_system0.33530346
155MP0000613_abnormal_salivary_gland0.33381969
156MP0003303_peritoneal_inflammation0.33196237
157MP0003635_abnormal_synaptic_transmissio0.33167552
158MP0002019_abnormal_tumor_incidence0.33152505
159MP0001853_heart_inflammation0.32496478
160MP0005084_abnormal_gallbladder_morpholo0.32476544
161MP0003787_abnormal_imprinting0.31795426
162MP0005408_hypopigmentation0.31327569
163MP0002396_abnormal_hematopoietic_system0.31321763
164MP0003279_aneurysm0.30858450
165MP0010307_abnormal_tumor_latency0.30426418
166MP0001727_abnormal_embryo_implantation0.30261522
167MP0002148_abnormal_hypersensitivity_rea0.30160332

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.96894811
2Abnormal respiratory epithelium morphology (HP:0012253)8.71137629
3Abnormal respiratory motile cilium morphology (HP:0005938)8.71137629
4Abnormal respiratory motile cilium physiology (HP:0012261)8.54130390
5Nasal polyposis (HP:0100582)7.78024096
6Chronic bronchitis (HP:0004469)7.24480611
7Rhinitis (HP:0012384)6.95846525
8Abnormal ciliary motility (HP:0012262)6.67534275
9Infertility (HP:0000789)6.66348656
10Abnormality of the nasal mucosa (HP:0000433)6.36915848
11Bronchitis (HP:0012387)5.43208771
12Attenuation of retinal blood vessels (HP:0007843)5.33768611
13Bony spicule pigmentary retinopathy (HP:0007737)5.21792552
14Male infertility (HP:0003251)5.05357367
15Bronchiectasis (HP:0002110)5.01015375
16Resting tremor (HP:0002322)4.61038860
17Chronic hepatic failure (HP:0100626)4.36370254
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.31595005
19Abnormal rod and cone electroretinograms (HP:0008323)4.27717716
20Recurrent bronchitis (HP:0002837)4.22360878
21Abnormality of macular pigmentation (HP:0008002)4.13381992
22Hypoplastic ischia (HP:0003175)4.02566452
23Nephronophthisis (HP:0000090)3.98689328
24Potter facies (HP:0002009)3.92786618
25Facial shape deformation (HP:0011334)3.92786618
26Enlarged epiphyses (HP:0010580)3.82283951
27Recurrent sinusitis (HP:0011108)3.76844101
28Abnormal spermatogenesis (HP:0008669)3.71919159
29Cone-rod dystrophy (HP:0000548)3.65311650
30Recurrent otitis media (HP:0000403)3.59339438
31Abnormality of the ischium (HP:0003174)3.58285874
32Aplasia/Hypoplasia of the earlobes (HP:0009906)3.53316088
33Generalized aminoaciduria (HP:0002909)3.21802093
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.21150608
35Unilateral renal agenesis (HP:0000122)3.16644799
36Hypoplasia of the thymus (HP:0000778)3.11517757
37Abnormality of the renal medulla (HP:0100957)3.00827023
38Postural instability (HP:0002172)2.91515022
39Progressive sensorineural hearing impairment (HP:0000408)2.91379523
40Hypoalphalipoproteinemia (HP:0003233)2.74248574
41Impulsivity (HP:0100710)2.68890946
42Abnormality of the aortic arch (HP:0012303)2.68777868
43Renal dysplasia (HP:0000110)2.65148669
44Tubulointerstitial nephritis (HP:0001970)2.63269439
45Progressive cerebellar ataxia (HP:0002073)2.55027867
46Abnormality of potassium homeostasis (HP:0011042)2.52044183
47Abnormality of dental color (HP:0011073)2.49714210
48Amelogenesis imperfecta (HP:0000705)2.48147530
49Abnormality of the costochondral junction (HP:0000919)2.46537962
50Cholecystitis (HP:0001082)2.38483385
51Abnormal gallbladder physiology (HP:0012438)2.38483385
52Tubular atrophy (HP:0000092)2.36776227
53Portal hypertension (HP:0001409)2.33385170
54Abnormality of midbrain morphology (HP:0002418)2.31286816
55Molar tooth sign on MRI (HP:0002419)2.31286816
56Renovascular hypertension (HP:0100817)2.30681136
57Menstrual irregularities (HP:0000858)2.29896174
58Ventricular tachycardia (HP:0004756)2.29458741
59Insulin-resistant diabetes mellitus (HP:0000831)2.28073110
60Tubulointerstitial abnormality (HP:0001969)2.24559380
61Flattened epiphyses (HP:0003071)2.24078695
62Heterotopia (HP:0002282)2.23890590
63Epiphyseal dysplasia (HP:0002656)2.20587413
64Gonadotropin excess (HP:0000837)2.19640728
65Abnormality of the parathyroid morphology (HP:0011766)2.18108373
66Absent epiphyses (HP:0010577)2.17056044
67Azoospermia (HP:0000027)2.16917780
68Abnormality of the hepatic vasculature (HP:0006707)2.12591912
69Osteomalacia (HP:0002749)2.08140456
70Abnormality of the pubic bones (HP:0003172)2.07260680
71Abnormality of the epiphysis of the femoral head (HP:0010574)2.06115779
72Focal segmental glomerulosclerosis (HP:0000097)2.05834302
73Myokymia (HP:0002411)2.02604737
74Retrobulbar optic neuritis (HP:0100654)2.02139301
75Optic neuritis (HP:0100653)2.02139301
76Hyponatremia (HP:0002902)2.02082723
77Dyschromatopsia (HP:0007641)2.01845389
78Widely patent fontanelles and sutures (HP:0004492)2.00532812
79Dynein arm defect of respiratory motile cilia (HP:0012255)12.9057416
80Absent/shortened dynein arms (HP:0200106)12.9057416
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0910532
82Chronic sinusitis (HP:0011109)1.98078585
83Pendular nystagmus (HP:0012043)1.97184687
84Tetany (HP:0001281)1.94617121
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94197438
86Abnormality of femoral epiphyses (HP:0006499)1.92512632
87Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.92512632
88Optic nerve hypoplasia (HP:0000609)1.92481246
89Medial flaring of the eyebrow (HP:0010747)1.89830730
90Spastic tetraparesis (HP:0001285)1.87863143
91Recurrent corneal erosions (HP:0000495)1.86275743
92Progressive hearing impairment (HP:0001730)1.86274163
93Hypophosphatemic rickets (HP:0004912)1.84170392
94Abnormality of the femoral head (HP:0003368)1.82618391
95Hyperthyroidism (HP:0000836)1.82518460
96Hyperuricemia (HP:0002149)1.82293095
97Increased purine levels (HP:0004368)1.82293095
98Recurrent pneumonia (HP:0006532)1.82108429
99Transposition of the great arteries (HP:0001669)1.82006422
100Abnormal connection of the cardiac segments (HP:0011545)1.82006422
101Abnormal ventriculo-arterial connection (HP:0011563)1.82006422
102Flat capital femoral epiphysis (HP:0003370)1.81589249
103Sensory axonal neuropathy (HP:0003390)1.79864942
104Tubulointerstitial fibrosis (HP:0005576)1.78883065
105Myositis (HP:0100614)1.76144690
106Choroideremia (HP:0001139)1.74462785
107Orchitis (HP:0100796)1.72348691
108T lymphocytopenia (HP:0005403)1.70745091
109Decreased central vision (HP:0007663)1.68604238
110Hemorrhage of the eye (HP:0011885)1.65815335
111Abnormal drinking behavior (HP:0030082)1.64258164
112Polydipsia (HP:0001959)1.64258164
113Abnormality of renal excretion (HP:0011036)1.64101611
114Postaxial foot polydactyly (HP:0001830)1.64001386
115Abnormality of the renal cortex (HP:0011035)1.61651194
116Abnormality of T cell number (HP:0011839)1.60531926
117Stage 5 chronic kidney disease (HP:0003774)1.56113255
118Congenital hepatic fibrosis (HP:0002612)1.54484477
119Asymmetric septal hypertrophy (HP:0001670)1.52150045
120Chronic otitis media (HP:0000389)1.49596611
121Bile duct proliferation (HP:0001408)1.48872164
122Abnormal biliary tract physiology (HP:0012439)1.48872164
123Stomatitis (HP:0010280)1.48807558
124Truncal obesity (HP:0001956)1.48498193
125Short ribs (HP:0000773)1.47862111
126Easy fatigability (HP:0003388)1.47317125
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.45816803
128Absent frontal sinuses (HP:0002688)1.42141279
129Abnormality of the lower motor neuron (HP:0002366)1.42066906
130Constricted visual fields (HP:0001133)1.41728716
131Dysmetric saccades (HP:0000641)1.40467632
132Amyotrophic lateral sclerosis (HP:0007354)1.38659930
133Abnormal urine output (HP:0012590)1.38413536
134Oculomotor apraxia (HP:0000657)1.37711202
135Hyperkalemia (HP:0002153)1.34288319
136Abnormality of permanent molar morphology (HP:0011071)1.28264073
137Abnormality of the dental root (HP:0006486)1.28264073
138Taurodontia (HP:0000679)1.28264073
139Deformed sella turcica (HP:0002681)1.27475195
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.27360360
141Loss of speech (HP:0002371)1.27260147
142Bundle branch block (HP:0011710)1.23428784
143Elevated erythrocyte sedimentation rate (HP:0003565)1.22841860
144Abnormality of ocular smooth pursuit (HP:0000617)1.21177731
145Bell-shaped thorax (HP:0001591)1.19950487
146Abnormality of the dental pulp (HP:0006479)1.18406700
147Fatigable weakness (HP:0003473)1.18318394
148Abnormality of the neuromuscular junction (HP:0003398)1.18318394
149Fatigue (HP:0012378)1.17603491
150Congenital malformation of the right heart (HP:0011723)1.16994775
151Double outlet right ventricle (HP:0001719)1.16994775
152Postaxial hand polydactyly (HP:0001162)1.16817764
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.16763141
154Myoglobinuria (HP:0002913)1.16675041
155Polyuria (HP:0000103)1.16598900
156Keratoconjunctivitis sicca (HP:0001097)1.16407773
157Neurofibrillary tangles (HP:0002185)1.16092480
158Abnormality of saccadic eye movements (HP:0000570)1.15842686
159Arterial thrombosis (HP:0004420)1.15831410
160Nephropathy (HP:0000112)1.15452706
161Abnormality of molar morphology (HP:0011070)1.14805932
162Abnormality of molar (HP:0011077)1.14805932
163Abnormality of T cells (HP:0002843)1.12629354
164Short femoral neck (HP:0100864)1.12013404
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.11909663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.48646314
2PDK37.65558598
3PDK47.65558598
4TESK15.87218614
5DDR25.12117598
6PDK24.98159041
7PRKD34.95341364
8ICK4.34026374
9INSRR4.11909561
10MAP4K23.84607821
11BRD43.12698763
12PLK23.09945226
13STK38L2.15067370
14PTK2B2.02261843
15WNK41.96676004
16MAP4K11.92731194
17PNCK1.85561399
18PIK3CG1.80674290
19EEF2K1.79318997
20MST1R1.74239261
21STK391.73890764
22NEK21.72568899
23STK381.58788407
24DYRK1B1.49017926
25TXK1.48057517
26PDK11.31386629
27CDK71.30486113
28ITK1.18831312
29TYRO31.17273915
30MAP3K91.09765456
31KSR21.07283426
32ZAP701.06606304
33JAK30.93853773
34PASK0.93186950
35LATS20.90777258
36STK100.89786136
37IRAK10.84816301
38AKT30.84527697
39WNK10.79937888
40CAMK1D0.79192060
41LMTK20.77889178
42MAP3K100.77850138
43UHMK10.75667772
44BRAF0.72927854
45FGFR40.72418627
46CAMK1G0.71477997
47RPS6KA20.69574334
48MAP3K110.69559959
49PRKAA20.68010683
50DYRK30.67528114
51PRKG10.63346464
52TESK20.62058415
53PDPK10.62006390
54MAP2K60.61871501
55MAP3K20.61712019
56MAP2K20.60421759
57TYK20.59946448
58TEC0.58843039
59PRKCQ0.55451545
60TRIB30.55019443
61MAP3K80.53841136
62MARK20.53228376
63CAMK10.53180958
64CSK0.51327928
65ROCK10.51299671
66MAPK150.51103251
67CHEK10.48815303
68CDK30.48452578
69RIPK40.47242455
70MUSK0.46613615
71LCK0.45970403
72LATS10.44638430
73STK30.44161200
74CDK120.43048626
75CHEK20.42653483
76MARK10.40412254
77BMPR1B0.40197889
78CDK10.40026054
79RPS6KL10.39484151
80RPS6KC10.39484151
81MAPK10.39422153
82BTK0.38845207
83IRAK20.38760365
84SGK2230.38533699
85SGK4940.38533699
86NTRK20.38054788
87MTOR0.37795420
88RPS6KA60.36257808
89HCK0.36185593
90EPHB10.36086802
91TIE10.35857707
92GRK60.35720962
93PIM10.34945456
94NTRK30.34887866
95FGFR30.34783242
96CAMK40.34703476
97TTK0.34699590
98MARK30.34187708
99ATM0.32326858
100ARAF0.32170233
101MAP3K10.31800092
102TAOK10.30948881
103CDC70.30766347
104PAK10.30743618
105PRKCZ0.30269416
106CLK10.28324918
107PAK20.28058678
108SGK10.26206734
109FRK0.26012864
110IKBKE0.25909589
111CDK40.25304186
112MAPK100.25026478
113ATR0.23691322
114JAK10.23317403
115CCNB10.22949399
116MAPK140.21450483
117PRKG20.21046886
118CDK60.20368434
119MET0.20010582
120PRKCH0.17707724
121BRSK10.17616811
122AKT10.17101595
123BLK0.16963743
124MAP3K40.16624202
125SYK0.16306743
126MAPK110.16118124
127PAK40.15963948
128PRKCG0.15637273
129PKN10.14440959
130OXSR10.13550281
131MAP3K140.13295204
132TBK10.13133578
133RPS6KB10.12913035
134EGFR0.12744623
135PDGFRB0.12169802
136PRKACB0.11813434
137FER0.10324944
138PRKACA0.10062351
139ADRBK20.09804871
140IKBKB0.09622464
141RPS6KA10.09157130
142CSNK1D0.08823438
143PRKAA10.08474397
144CSF1R0.08247797
145PKN20.07999634
146PINK10.07445905
147CAMKK10.07328106
148NLK0.06850967
149AURKA0.06759068
150MAP3K70.06702644
151SGK20.06492760
152CDK20.06244685
153MAPK90.05969783
154PRKCB0.05742666
155CAMK2A0.05629068
156PTK60.04621282
157SIK20.04246894
158GSK3B0.04113208
159MAP3K50.03756326
160MAPK80.03413261
161NEK60.03378372
162JAK20.02991807
163STK110.02284672
164CHUK0.02242647
165ALK0.02235529
166INSR0.02169075

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.11940262
2Fatty acid biosynthesis_Homo sapiens_hsa000614.27077263
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.26688263
4Olfactory transduction_Homo sapiens_hsa047403.68459240
5Butanoate metabolism_Homo sapiens_hsa006502.80430540
6Pyruvate metabolism_Homo sapiens_hsa006202.68057286
7Antigen processing and presentation_Homo sapiens_hsa046122.57927771
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.53813920
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.50132438
10Vitamin B6 metabolism_Homo sapiens_hsa007502.49266256
11Glucagon signaling pathway_Homo sapiens_hsa049222.36687373
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.34363934
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26693677
14Linoleic acid metabolism_Homo sapiens_hsa005912.25589424
15T cell receptor signaling pathway_Homo sapiens_hsa046602.21317386
16Primary immunodeficiency_Homo sapiens_hsa053401.99515426
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88785659
18Taste transduction_Homo sapiens_hsa047421.84139394
19Glycerolipid metabolism_Homo sapiens_hsa005611.81366406
20Dorso-ventral axis formation_Homo sapiens_hsa043201.79768289
21Basal transcription factors_Homo sapiens_hsa030221.75353462
22Measles_Homo sapiens_hsa051621.67877504
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.65789225
24Propanoate metabolism_Homo sapiens_hsa006401.65292025
25Type II diabetes mellitus_Homo sapiens_hsa049301.59830075
26Phenylalanine metabolism_Homo sapiens_hsa003601.53013978
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.52793114
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49406342
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45425644
30Oocyte meiosis_Homo sapiens_hsa041141.42513687
31Selenocompound metabolism_Homo sapiens_hsa004501.41521856
32mRNA surveillance pathway_Homo sapiens_hsa030151.39564811
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36013090
34Fructose and mannose metabolism_Homo sapiens_hsa000511.35880604
35PPAR signaling pathway_Homo sapiens_hsa033201.31937338
36Pentose phosphate pathway_Homo sapiens_hsa000301.29268729
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27053640
38Arginine and proline metabolism_Homo sapiens_hsa003301.26430565
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26022939
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25212152
41Mineral absorption_Homo sapiens_hsa049781.20315442
42Legionellosis_Homo sapiens_hsa051341.19529661
43Fanconi anemia pathway_Homo sapiens_hsa034601.14004671
44Phototransduction_Homo sapiens_hsa047441.13934921
45Renin-angiotensin system_Homo sapiens_hsa046141.10948176
46RNA transport_Homo sapiens_hsa030131.10035002
47Protein digestion and absorption_Homo sapiens_hsa049741.09228304
48Graft-versus-host disease_Homo sapiens_hsa053321.05093767
49Renin secretion_Homo sapiens_hsa049241.04734410
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.03443739
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99975491
52Amphetamine addiction_Homo sapiens_hsa050310.99230307
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.98149538
54B cell receptor signaling pathway_Homo sapiens_hsa046620.97640002
55Arginine biosynthesis_Homo sapiens_hsa002200.92293842
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.91529025
57Carbon metabolism_Homo sapiens_hsa012000.89244946
58Toxoplasmosis_Homo sapiens_hsa051450.88434250
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.88276272
60Morphine addiction_Homo sapiens_hsa050320.86817547
61Calcium signaling pathway_Homo sapiens_hsa040200.86752124
62Fat digestion and absorption_Homo sapiens_hsa049750.80925734
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79758238
64Estrogen signaling pathway_Homo sapiens_hsa049150.79696224
65VEGF signaling pathway_Homo sapiens_hsa043700.79676237
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79618847
67Ether lipid metabolism_Homo sapiens_hsa005650.79440039
68Osteoclast differentiation_Homo sapiens_hsa043800.76684938
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76498577
70Nicotine addiction_Homo sapiens_hsa050330.76224943
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.75665171
72Endocytosis_Homo sapiens_hsa041440.74679984
73Retinol metabolism_Homo sapiens_hsa008300.73543870
74Inositol phosphate metabolism_Homo sapiens_hsa005620.73193568
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72806078
76Fatty acid degradation_Homo sapiens_hsa000710.71001081
77Allograft rejection_Homo sapiens_hsa053300.69702191
78Fatty acid metabolism_Homo sapiens_hsa012120.69554199
79Purine metabolism_Homo sapiens_hsa002300.69503453
80Influenza A_Homo sapiens_hsa051640.69467144
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67946557
82Circadian entrainment_Homo sapiens_hsa047130.67825321
83Herpes simplex infection_Homo sapiens_hsa051680.66914968
84Tyrosine metabolism_Homo sapiens_hsa003500.64891442
85Synaptic vesicle cycle_Homo sapiens_hsa047210.63409163
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.63304028
87Type I diabetes mellitus_Homo sapiens_hsa049400.61806949
88ABC transporters_Homo sapiens_hsa020100.60820077
89Cardiac muscle contraction_Homo sapiens_hsa042600.60498450
90Long-term potentiation_Homo sapiens_hsa047200.59307943
91Biosynthesis of amino acids_Homo sapiens_hsa012300.59173413
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57462577
93HIF-1 signaling pathway_Homo sapiens_hsa040660.56479770
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.56051951
95Glutamatergic synapse_Homo sapiens_hsa047240.54939269
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.54413530
97Viral carcinogenesis_Homo sapiens_hsa052030.53879195
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53639477
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.52532093
100Insulin secretion_Homo sapiens_hsa049110.51824176
101Thyroid hormone synthesis_Homo sapiens_hsa049180.51541300
102Epstein-Barr virus infection_Homo sapiens_hsa051690.51274444
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50454158
104Hematopoietic cell lineage_Homo sapiens_hsa046400.47762447
105Viral myocarditis_Homo sapiens_hsa054160.47494114
106Hedgehog signaling pathway_Homo sapiens_hsa043400.45796173
107AMPK signaling pathway_Homo sapiens_hsa041520.45345615
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45100796
109Autoimmune thyroid disease_Homo sapiens_hsa053200.45066050
110HTLV-I infection_Homo sapiens_hsa051660.44931261
111Bile secretion_Homo sapiens_hsa049760.44858449
112MAPK signaling pathway_Homo sapiens_hsa040100.44129703
113Acute myeloid leukemia_Homo sapiens_hsa052210.39727827
114Pancreatic secretion_Homo sapiens_hsa049720.39620311
115Salmonella infection_Homo sapiens_hsa051320.36415637
116Gastric acid secretion_Homo sapiens_hsa049710.36367213
117Serotonergic synapse_Homo sapiens_hsa047260.35923377
118RNA degradation_Homo sapiens_hsa030180.35110646
119Cholinergic synapse_Homo sapiens_hsa047250.33813437
120Tight junction_Homo sapiens_hsa045300.33246843
121Salivary secretion_Homo sapiens_hsa049700.32211325
122Shigellosis_Homo sapiens_hsa051310.30316419
123Insulin resistance_Homo sapiens_hsa049310.27957489
124Systemic lupus erythematosus_Homo sapiens_hsa053220.27777321
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27372268
126GABAergic synapse_Homo sapiens_hsa047270.27133949
127cAMP signaling pathway_Homo sapiens_hsa040240.27054926
128Oxytocin signaling pathway_Homo sapiens_hsa049210.26701881
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.25763033
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25636935
131Glutathione metabolism_Homo sapiens_hsa004800.23865885
132Nitrogen metabolism_Homo sapiens_hsa009100.23734878
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23198393
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.22961979
135ECM-receptor interaction_Homo sapiens_hsa045120.21886343
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19360515
137Prolactin signaling pathway_Homo sapiens_hsa049170.18960126
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16046204
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15986577
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15845743
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15730942

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