FAM71A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with the Rab2B small GTPase and may be important for integrity of the Golgi body. A knockdown of this gene induces fragmentation of the Golgi, similar to the effect seen with a knockdown of the Rab2B small GTPase. The encoded protein has an N-terminal Rab-binding domain specific for Rab2B. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.16132173
2sperm motility (GO:0030317)8.98104714
3cell wall macromolecule catabolic process (GO:0016998)8.01703815
4cell wall macromolecule metabolic process (GO:0044036)8.01703815
5acrosome reaction (GO:0007340)7.95232474
6chromosome condensation (GO:0030261)7.85097698
7DNA packaging (GO:0006323)7.49684535
8response to pheromone (GO:0019236)7.23309406
9multicellular organism reproduction (GO:0032504)7.01621929
10plasma membrane fusion (GO:0045026)6.97131893
11epithelial cilium movement (GO:0003351)6.95049047
12phosphatidylethanolamine biosynthetic process (GO:0006646)6.89358238
13sperm-egg recognition (GO:0035036)6.59262502
14acrosome assembly (GO:0001675)6.57575021
15axonemal dynein complex assembly (GO:0070286)6.56536535
16phosphatidylethanolamine metabolic process (GO:0046337)6.34612555
17regulation of phosphoprotein phosphatase activity (GO:0043666)6.33246080
18reproduction (GO:0000003)6.20096859
19cilium movement (GO:0003341)5.91474259
20cilium or flagellum-dependent cell motility (GO:0001539)5.90671724
21binding of sperm to zona pellucida (GO:0007339)5.89149681
22cell-cell recognition (GO:0009988)5.87193834
23spermatid development (GO:0007286)5.78474281
24protein polyglutamylation (GO:0018095)5.72825371
25rRNA methylation (GO:0031167)5.67084374
26L-ascorbic acid metabolic process (GO:0019852)5.61732610
27motile cilium assembly (GO:0044458)5.57844500
28microtubule polymerization or depolymerization (GO:0031109)5.57014643
29negative regulation of inclusion body assembly (GO:0090084)5.36698366
30protein-DNA complex disassembly (GO:0032986)5.35140761
31nucleosome disassembly (GO:0006337)5.35140761
32cellular ketone body metabolic process (GO:0046950)5.29355593
33microtubule severing (GO:0051013)5.10062064
34polyamine biosynthetic process (GO:0006596)5.06744876
35organic cation transport (GO:0015695)5.05407861
36protein targeting to Golgi (GO:0000042)5.01389895
37coenzyme catabolic process (GO:0009109)4.95844841
38cellular response to arsenic-containing substance (GO:0071243)4.91609441
39establishment of protein localization to Golgi (GO:0072600)4.81000793
40single fertilization (GO:0007338)4.73568013
41ketone body metabolic process (GO:1902224)4.65793645
42rRNA modification (GO:0000154)4.64901355
43response to acidic pH (GO:0010447)4.64337096
44retrograde transport, vesicle recycling within Golgi (GO:0000301)4.63368747
45regulation of Rab GTPase activity (GO:0032313)4.43524894
46positive regulation of Rab GTPase activity (GO:0032851)4.43524894
47regulation of cilium movement (GO:0003352)4.41921157
48synaptonemal complex organization (GO:0070193)4.40665652
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.36787723
50centriole assembly (GO:0098534)4.16455356
51axoneme assembly (GO:0035082)4.14237997
52regulation of cell proliferation involved in kidney development (GO:1901722)4.13372270
53spermatogenesis (GO:0007283)4.10113134
54positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.08868406
55regulation of transcription involved in cell fate commitment (GO:0060850)4.08223221
56male gamete generation (GO:0048232)4.07700756
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07146578
58regulation of inclusion body assembly (GO:0090083)4.04317648
59fertilization (GO:0009566)4.00083544
60positive regulation of chemokine secretion (GO:0090197)3.95345612
61sperm capacitation (GO:0048240)3.90972982
62centriole replication (GO:0007099)3.86486374
63cellular response to pH (GO:0071467)3.81904794
64gamete generation (GO:0007276)3.78710425
65positive regulation of catecholamine secretion (GO:0033605)3.75600668
66chromatin silencing (GO:0006342)3.71467861
67histone H3-K9 demethylation (GO:0033169)3.71140240
68ventricular system development (GO:0021591)3.57829339
69regulation of chemokine secretion (GO:0090196)3.57335675
70protein localization to Golgi apparatus (GO:0034067)3.55745868
71piRNA metabolic process (GO:0034587)3.49817662
72RNA destabilization (GO:0050779)3.47622813
73histone exchange (GO:0043486)3.47294309
74nucleus organization (GO:0006997)3.44213425
75negative regulation of Rho protein signal transduction (GO:0035024)3.37771217
76cranial nerve morphogenesis (GO:0021602)3.37594920
77male meiosis (GO:0007140)3.37111104
78cellular biogenic amine biosynthetic process (GO:0042401)3.36456960
79sexual reproduction (GO:0019953)3.34759114
80male sex determination (GO:0030238)3.30460182
81photoreceptor cell differentiation (GO:0046530)3.28832056
82eye photoreceptor cell differentiation (GO:0001754)3.28832056
83energy homeostasis (GO:0097009)3.28710336
84negative regulation of leukocyte chemotaxis (GO:0002689)3.27195423
85microtubule depolymerization (GO:0007019)3.24946681
86amine biosynthetic process (GO:0009309)3.24205041
87calcium ion-dependent exocytosis (GO:0017156)3.21078601
88regulation of ARF GTPase activity (GO:0032312)3.18242277
89regulation of meiosis I (GO:0060631)3.14717037
90germ cell development (GO:0007281)3.14486709
91regulation of microtubule-based movement (GO:0060632)3.11493351
92cellular process involved in reproduction in multicellular organism (GO:0022412)3.11365271
93multicellular organismal reproductive process (GO:0048609)3.10557856
94one-carbon compound transport (GO:0019755)3.08178195
95positive regulation of glycolytic process (GO:0045821)3.05218486
96positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.05154945
97left/right pattern formation (GO:0060972)3.02419782
98polyol transport (GO:0015791)3.01194609
99protein K11-linked deubiquitination (GO:0035871)2.98727050
100detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.98435118
101glutathione derivative metabolic process (GO:1901685)2.98343516
102glutathione derivative biosynthetic process (GO:1901687)2.98343516
103synaptonemal complex assembly (GO:0007130)2.93955704
104peptidyl-threonine dephosphorylation (GO:0035970)2.92966316
105positive regulation of cholesterol efflux (GO:0010875)2.91070137
106nucleoside diphosphate catabolic process (GO:0009134)2.89289080
107artery smooth muscle contraction (GO:0014824)2.88998947
108oxygen transport (GO:0015671)2.88818663
109cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.86951761
110mitochondrion degradation (GO:0000422)2.85966858
111protein depolymerization (GO:0051261)2.81466788
112microglial cell activation (GO:0001774)2.81237567
113xenobiotic catabolic process (GO:0042178)2.80714957
114stress fiber assembly (GO:0043149)2.80571498
115positive regulation of glomerulus development (GO:0090193)2.79929525
116regulation of monocyte chemotaxis (GO:0090025)2.79858291
117cofactor catabolic process (GO:0051187)2.77953357
118response to laminar fluid shear stress (GO:0034616)2.77390722
119membrane protein intracellular domain proteolysis (GO:0031293)2.74697091
120interferon-gamma secretion (GO:0072643)2.73205981
121uronic acid metabolic process (GO:0006063)2.72842093
122glucuronate metabolic process (GO:0019585)2.72842093
123positive regulation of meiotic cell cycle (GO:0051446)2.72472286
124Leydig cell differentiation (GO:0033327)2.71224275
125cell recognition (GO:0008037)2.70979519
126cellular glucuronidation (GO:0052695)2.70879044
127genitalia morphogenesis (GO:0035112)2.69904138
128regulation of centriole replication (GO:0046599)2.69535690
129cerebral cortex neuron differentiation (GO:0021895)2.68301449
130response to muramyl dipeptide (GO:0032495)2.64223453
131homeostasis of number of cells within a tissue (GO:0048873)2.64171121
132polyamine metabolic process (GO:0006595)2.63253062
133regulation of phosphatase activity (GO:0010921)2.63191958
134single strand break repair (GO:0000012)2.62776366
135actin filament capping (GO:0051693)2.62728204
136potassium ion export (GO:0071435)2.61808693
137regulation of phospholipase A2 activity (GO:0032429)2.61297831
138positive regulation of meiosis (GO:0045836)2.59672332
139spermatid nucleus differentiation (GO:0007289)2.58108123
140negative regulation of skeletal muscle tissue development (GO:0048642)2.57427074
141multicellular organismal development (GO:0007275)2.57388049
142tonic smooth muscle contraction (GO:0014820)2.54784511
143inositol phosphate-mediated signaling (GO:0048016)2.51949379
144macrophage activation (GO:0042116)2.50741566
145mitotic cell cycle arrest (GO:0071850)2.44940120
146positive regulation of sterol transport (GO:0032373)2.42532396
147positive regulation of cholesterol transport (GO:0032376)2.42532396
148regulation of glomerulus development (GO:0090192)2.41024237
149sequestering of extracellular ligand from receptor (GO:0035581)2.40228651
150positive regulation of macrophage activation (GO:0043032)2.38405717
151lymph vessel development (GO:0001945)2.38150813
152regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.37981907
153positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.37981907
154detection of other organism (GO:0098543)2.31477640
155cellular response to fluid shear stress (GO:0071498)2.31343176
156response to nitrosative stress (GO:0051409)2.30797948
157prostanoid biosynthetic process (GO:0046457)2.28814642
158prostaglandin biosynthetic process (GO:0001516)2.28814642
159glycerol ether metabolic process (GO:0006662)2.28055289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.32018471
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.22008239
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.68388690
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.54731005
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.54509762
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.94840368
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.64445621
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54986956
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.54466805
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42888369
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26464137
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14342828
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.13790930
14CBP_20019798_ChIP-Seq_JUKART_Human2.13790930
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11019597
16NANOG_20526341_ChIP-Seq_ESCs_Human2.09044335
17FUS_26573619_Chip-Seq_HEK293_Human2.08054998
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02712411
19ERA_21632823_ChIP-Seq_H3396_Human2.02161602
20RAC3_21632823_ChIP-Seq_H3396_Human1.98200126
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.92103207
22MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.84432810
23* CTCF_27219007_Chip-Seq_Bcells_Human1.83743032
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.80167566
25EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.77887663
26SMC4_20622854_ChIP-Seq_HELA_Human1.74760501
27ELF1_20517297_ChIP-Seq_JURKAT_Human1.72489402
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70436933
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70376590
30EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.69140653
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68798855
32MYC_19829295_ChIP-Seq_ESCs_Human1.67031524
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65639383
34OCT4_20526341_ChIP-Seq_ESCs_Human1.62405845
35CJUN_26792858_Chip-Seq_BT549_Human1.60461850
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58747907
37IGF1R_20145208_ChIP-Seq_DFB_Human1.57032790
38AR_21572438_ChIP-Seq_LNCaP_Human1.55949694
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.55569262
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55413126
41CTCF_20526341_ChIP-Seq_ESCs_Human1.51740247
42VDR_22108803_ChIP-Seq_LS180_Human1.50576558
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50566515
44BCL6_27268052_Chip-Seq_Bcells_Human1.49630054
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.48027574
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.44583878
47ERG_20517297_ChIP-Seq_VCAP_Human1.42578513
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.41796493
49TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41475931
50P300_27268052_Chip-Seq_Bcells_Human1.39237742
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.39221936
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37698113
53YY1_22570637_ChIP-Seq_MALME-3M_Human1.37595576
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37322106
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36648447
56BCOR_27268052_Chip-Seq_Bcells_Human1.35244583
57* E2F1_20622854_ChIP-Seq_HELA_Human1.34995650
58* PHF8_20622854_ChIP-Seq_HELA_Human1.34268460
59TBL1_22424771_ChIP-Seq_293T_Human1.33874971
60AHR_22903824_ChIP-Seq_MCF-7_Human1.32641639
61TCF4_18268006_ChIP-ChIP_LS174T_Human1.32571510
62* LXR_22292898_ChIP-Seq_THP-1_Human1.31718177
63* TP63_22573176_ChIP-Seq_HFKS_Human1.31501007
64* P68_20966046_ChIP-Seq_HELA_Human1.31405403
65P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.31114081
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29813274
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28480584
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28463541
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28177405
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28071438
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27658638
72* OCT1_27270436_Chip-Seq_PROSTATE_Human1.27024562
73HNFA_21074721_ChIP-Seq_CACO-2_Human1.25996364
74TAF2_19829295_ChIP-Seq_ESCs_Human1.25152869
75* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24836520
76* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24248479
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.23185343
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.20337321
79* TP53_18474530_ChIP-ChIP_U2OS_Human1.20160985
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20056168
81RUNX2_22187159_ChIP-Seq_PCA_Human1.19259051
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18964710
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17710409
84TAF15_26573619_Chip-Seq_HEK293_Human1.17429151
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.16843217
86NANOG_19829295_ChIP-Seq_ESCs_Human1.15961027
87SOX2_19829295_ChIP-Seq_ESCs_Human1.15961027
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14599644
89* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14566480
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13867931
91GF1_26923725_Chip-Seq_HPCs_Mouse1.13046196
92NFYB_21822215_ChIP-Seq_K562_Human1.11940023
93VDR_24787735_ChIP-Seq_THP-1_Human1.11561726
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11342062
95DROSHA_22980978_ChIP-Seq_HELA_Human1.11108983
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10836847
97* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10715379
98* TAL1_26923725_Chip-Seq_HPCs_Mouse1.10248747
99* GATA3_21878914_ChIP-Seq_MCF-7_Human1.09987551
100ETV1_20927104_ChIP-Seq_GIST48_Human1.09695207
101STAT1_17558387_ChIP-Seq_HELA_Human1.08568920
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08563231
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08184489
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08122876
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.07482874
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07478075
107* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07299246
108PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06591392
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06108822
110* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05964991
111* RBPJ_21746931_ChIP-Seq_IB4_Human1.05855609
112SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05230042
113ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04982779
114HOXB7_26014856_ChIP-Seq_BT474_Human1.04764636
115SPI1_20517297_ChIP-Seq_HL60_Human1.04339021
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03376689
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02715138
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.02363297
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.01592434
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01482818
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01482818
122PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00894591
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.99991052
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99751873
125KDM2B_26808549_Chip-Seq_REH_Human0.99732548
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99608535
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99508458
128E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99406203
129EZH2_27294783_Chip-Seq_ESCs_Mouse0.96825503
130CSB_26484114_Chip-Seq_FIBROBLAST_Human0.96773313
131KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96500800
132CEBPB_22108803_ChIP-Seq_LS180_Human0.96063313
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.96013777
134* PHF8_20622853_ChIP-Seq_HELA_Human0.95091288
135CDX2_22108803_ChIP-Seq_LS180_Human0.94782450
136* TP63_23658742_ChIP-Seq_EP156T_Human0.94538666
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.94410961
138GF1B_26923725_Chip-Seq_HPCs_Mouse0.94341647
139SMAD4_21741376_ChIP-Seq_EPCs_Human0.94317907
140NFYA_21822215_ChIP-Seq_K562_Human0.94169105
141* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94090778
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94051605
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93955083
144* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93939815
145ESR2_21235772_ChIP-Seq_MCF-7_Human0.91943691
146SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91895560
147WDR5_24793694_ChIP-Seq_LNCAP_Human0.91044859
148EZH2_22144423_ChIP-Seq_EOC_Human0.90295991
149FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89860375
150RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89658133
151RUNX1_27514584_Chip-Seq_MCF-7_Human0.89061299
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88864509
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88724115
154SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88537177
155JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88071668
156HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88058166
157* NANOG_18555785_Chip-Seq_ESCs_Mouse0.87796814
158RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87580537
159STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87411137
160P300_19829295_ChIP-Seq_ESCs_Human0.86255128
161RNF2_27304074_Chip-Seq_NSC_Mouse0.85905477
162KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85451373
163KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85451373
164KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85451373
165ER_23166858_ChIP-Seq_MCF-7_Human0.84897434
166CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84806786
167TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84338941
168EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84093274
169* SMAD4_21799915_ChIP-Seq_A2780_Human0.83390678
170AR_25329375_ChIP-Seq_VCAP_Human0.83105259
171SMAD3_21741376_ChIP-Seq_ESCs_Human0.82471555
172STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.81883414
173SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81061902
174BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80926458
175* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80924433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.52803458
2MP0001958_emphysema3.82243551
3MP0006054_spinal_hemorrhage3.64490222
4MP0010368_abnormal_lymphatic_system3.62635517
5MP0003724_increased_susceptibility_to2.93630227
6MP0002254_reproductive_system_inflammat2.90066486
7MP0003279_aneurysm2.80376444
8MP0008004_abnormal_stomach_pH2.67772180
9MP0003828_pulmonary_edema2.62345238
10MP0003698_abnormal_male_reproductive2.61098905
11MP0003315_abnormal_perineum_morphology2.53494643
12MP0001542_abnormal_bone_strength2.53103292
13MP0003941_abnormal_skin_development2.52611039
14MP0005503_abnormal_tendon_morphology2.51807467
15MP0005377_hearing/vestibular/ear_phenot2.45197089
16MP0003878_abnormal_ear_physiology2.45197089
17MP0004883_abnormal_blood_vessel2.40363875
18MP0001929_abnormal_gametogenesis2.36999020
19MP0000678_abnormal_parathyroid_gland2.25020965
20MP0002009_preneoplasia2.13291651
21MP0001348_abnormal_lacrimal_gland2.08764041
22MP0001879_abnormal_lymphatic_vessel2.05241001
23MP0003718_maternal_effect2.04967473
24MP0002877_abnormal_melanocyte_morpholog1.98657717
25MP0005670_abnormal_white_adipose1.92700230
26MP0003191_abnormal_cellular_cholesterol1.75505746
27MP0002796_impaired_skin_barrier1.67169581
28MP0000767_abnormal_smooth_muscle1.63149414
29MP0005164_abnormal_response_to1.63124172
30MP0001851_eye_inflammation1.61581588
31MP0002295_abnormal_pulmonary_circulatio1.56109402
32MP0000049_abnormal_middle_ear1.53559042
33MP0009278_abnormal_bone_marrow1.52327286
34MP0005388_respiratory_system_phenotype1.51632401
35MP0002133_abnormal_respiratory_system1.51632401
36MP0010030_abnormal_orbit_morphology1.46367656
37MP0003646_muscle_fatigue1.42989164
38MP0003011_delayed_dark_adaptation1.40476673
39MP0002160_abnormal_reproductive_system1.38336445
40MP0000762_abnormal_tongue_morphology1.35490045
41MP0002210_abnormal_sex_determination1.33257087
42MP0002161_abnormal_fertility/fecundity1.32113940
43MP0009250_abnormal_appendicular_skeleto1.30146217
44MP0001984_abnormal_olfaction1.29469991
45MP0005499_abnormal_olfactory_system1.28686764
46MP0005394_taste/olfaction_phenotype1.28686764
47MP0008789_abnormal_olfactory_epithelium1.27908529
48MP0005508_abnormal_skeleton_morphology1.27280094
49MP0005275_abnormal_skin_tensile1.25763039
50MP0008875_abnormal_xenobiotic_pharmacok1.24505140
51MP0002060_abnormal_skin_morphology1.23638635
52MP0003136_yellow_coat_color1.23448655
53MP0005248_abnormal_Harderian_gland1.22411215
54MP0005395_other_phenotype1.22376757
55MP0003045_fibrosis1.21320630
56MP0005360_urolithiasis1.20265309
57MP0009379_abnormal_foot_pigmentation1.20107115
58MP0005423_abnormal_somatic_nervous1.19931774
59MP0002127_abnormal_cardiovascular_syste1.19312959
60MP0001177_atelectasis1.17131909
61MP0002249_abnormal_larynx_morphology1.14332884
62MP0003943_abnormal_hepatobiliary_system1.13812838
63MP0001145_abnormal_male_reproductive1.11520559
64MP0004484_altered_response_of1.10956466
65MP0001905_abnormal_dopamine_level1.10516082
66MP0003115_abnormal_respiratory_system1.08718294
67MP0001485_abnormal_pinna_reflex1.08284483
68MP0002138_abnormal_hepatobiliary_system1.07839583
69MP0010386_abnormal_urinary_bladder1.07111202
70MP0004510_myositis1.07107883
71MP0001486_abnormal_startle_reflex1.05123473
72MP0000653_abnormal_sex_gland1.04637017
73MP0002234_abnormal_pharynx_morphology1.04441605
74MP0008995_early_reproductive_senescence1.02846780
75MP0003690_abnormal_glial_cell1.02067786
76MP0001968_abnormal_touch/_nociception1.00226791
77MP0002928_abnormal_bile_duct0.98707959
78MP0002405_respiratory_system_inflammati0.97952562
79MP0002822_catalepsy0.97870158
80MP0005390_skeleton_phenotype0.96395594
81MP0002132_abnormal_respiratory_system0.96210501
82MP0005647_abnormal_sex_gland0.95549594
83MP0001849_ear_inflammation0.95309427
84MP0002282_abnormal_trachea_morphology0.93702336
85MP0001270_distended_abdomen0.93461349
86MP0001765_abnormal_ion_homeostasis0.92713973
87MP0001533_abnormal_skeleton_physiology0.91967912
88MP0000534_abnormal_ureter_morphology0.91157543
89MP0004272_abnormal_basement_membrane0.90320410
90MP0004742_abnormal_vestibular_system0.89959117
91MP0004859_abnormal_synaptic_plasticity0.88441831
92MP0004381_abnormal_hair_follicle0.88415192
93MP0003879_abnormal_hair_cell0.87704154
94MP0001963_abnormal_hearing_physiology0.87692587
95MP0005379_endocrine/exocrine_gland_phen0.86630149
96MP0003950_abnormal_plasma_membrane0.85454380
97MP0000026_abnormal_inner_ear0.84231599
98MP0002735_abnormal_chemical_nociception0.84113355
99MP0002998_abnormal_bone_remodeling0.84001417
100MP0003453_abnormal_keratinocyte_physiol0.83819192
101MP0002896_abnormal_bone_mineralization0.83398796
102MP0005167_abnormal_blood-brain_barrier0.83245943
103MP0004019_abnormal_vitamin_homeostasis0.83104226
104MP0008438_abnormal_cutaneous_collagen0.81328411
105MP0000383_abnormal_hair_follicle0.81025668
106MP0005397_hematopoietic_system_phenotyp0.80820909
107MP0001545_abnormal_hematopoietic_system0.80820909
108MP0000249_abnormal_blood_vessel0.80632906
109MP0000681_abnormal_thyroid_gland0.80260966
110MP0000566_synostosis0.79962802
111MP0009697_abnormal_copulation0.77896747
112MP0003566_abnormal_cell_adhesion0.77239873
113MP0005253_abnormal_eye_physiology0.76672000
114MP0010678_abnormal_skin_adnexa0.75349472
115MP0005310_abnormal_salivary_gland0.74814651
116MP0002653_abnormal_ependyma_morphology0.74636725
117MP0003936_abnormal_reproductive_system0.74229440
118MP0005551_abnormal_eye_electrophysiolog0.72417243
119MP0010234_abnormal_vibrissa_follicle0.70486849
120MP0003632_abnormal_nervous_system0.69995955
121MP0002177_abnormal_outer_ear0.69319459
122MP0000470_abnormal_stomach_morphology0.69226567
123MP0001501_abnormal_sleep_pattern0.69073030
124MP0002168_other_aberrant_phenotype0.68846102
125MP0002229_neurodegeneration0.68624238
126MP0001175_abnormal_lung_morphology0.68275965
127MP0001346_abnormal_lacrimal_gland0.67027986
128MP0003385_abnormal_body_wall0.66910673
129MP0001664_abnormal_digestion0.66517704
130MP0002233_abnormal_nose_morphology0.66013239
131MP0003186_abnormal_redox_activity0.64274534
132MP0000163_abnormal_cartilage_morphology0.64193257
133MP0003938_abnormal_ear_development0.63586206
134MP0003631_nervous_system_phenotype0.62489278
135MP0004085_abnormal_heartbeat0.62184801
136MP0001216_abnormal_epidermal_layer0.61286875
137MP0009115_abnormal_fat_cell0.61192311
138MP0000955_abnormal_spinal_cord0.60559048
139MP0009053_abnormal_anal_canal0.59936832
140MP0002067_abnormal_sensory_capabilities0.59494523
141MP0002115_abnormal_skeleton_extremities0.59251212
142MP0005165_increased_susceptibility_to0.59155551
143MP0001915_intracranial_hemorrhage0.58493357
144MP0002108_abnormal_muscle_morphology0.58468357
145MP0003252_abnormal_bile_duct0.57704851
146MP0000647_abnormal_sebaceous_gland0.56557858
147MP0002272_abnormal_nervous_system0.54486445
148MP0005166_decreased_susceptibility_to0.52312530
149MP0000538_abnormal_urinary_bladder0.52085299
150MP0005389_reproductive_system_phenotype0.51829331
151MP0002557_abnormal_social/conspecific_i0.51311685
152MP0000230_abnormal_systemic_arterial0.49732143
153MP0005367_renal/urinary_system_phenotyp0.47091259
154MP0000516_abnormal_urinary_system0.47091259
155MP0004036_abnormal_muscle_relaxation0.45968710
156MP0005451_abnormal_body_composition0.45871781
157MP0002572_abnormal_emotion/affect_behav0.44830534
158MP0003633_abnormal_nervous_system0.43698734
159MP0005595_abnormal_vascular_smooth0.43491236
160MP0005083_abnormal_biliary_tract0.43302411
161MP0008569_lethality_at_weaning0.42606698
162MP0001666_abnormal_nutrient_absorption0.41970580
163MP0004084_abnormal_cardiac_muscle0.41664803
164MP0003699_abnormal_female_reproductive0.41278385
165MP0005058_abnormal_lysosome_morphology0.40767866
166MP0001188_hyperpigmentation0.40175750
167MP0003635_abnormal_synaptic_transmissio0.39108123
168MP0005636_abnormal_mineral_homeostasis0.38760245
169MP0008877_abnormal_DNA_methylation0.38413318
170MP0005391_vision/eye_phenotype0.38048921

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.10509048
2Absent/shortened dynein arms (HP:0200106)8.38825618
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.38825618
4Resting tremor (HP:0002322)6.86036244
5Severe visual impairment (HP:0001141)6.81565578
6Abnormal respiratory motile cilium physiology (HP:0012261)6.42367818
7Abnormal respiratory epithelium morphology (HP:0012253)5.82763018
8Abnormal respiratory motile cilium morphology (HP:0005938)5.82763018
9Abnormal ciliary motility (HP:0012262)5.16610990
10Rhinitis (HP:0012384)5.05438303
11Redundant skin (HP:0001582)5.01842945
12Pulmonary artery stenosis (HP:0004415)4.81672748
13Attenuation of retinal blood vessels (HP:0007843)4.61504168
14Chronic bronchitis (HP:0004469)4.37105698
15Abnormal rod and cone electroretinograms (HP:0008323)4.27628162
16Postural instability (HP:0002172)4.24948582
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.02131076
18Abnormal sex determination (HP:0012244)3.93701228
19Sex reversal (HP:0012245)3.93701228
20Asymmetric septal hypertrophy (HP:0001670)3.76931966
21Abnormality of macular pigmentation (HP:0008002)3.62740303
22Chronic hepatic failure (HP:0100626)3.42410010
23Infertility (HP:0000789)3.39915285
24Short nail (HP:0001799)3.37913283
25Hypoplastic ischia (HP:0003175)3.37555885
26Hyperkalemia (HP:0002153)3.36673972
27Nasal polyposis (HP:0100582)3.32015713
28Elfin facies (HP:0004428)3.31854640
29Azoospermia (HP:0000027)3.29690696
30Osteolytic defects of the hand bones (HP:0009699)3.22308394
31Osteolytic defects of the phalanges of the hand (HP:0009771)3.22308394
32Renovascular hypertension (HP:0100817)3.17639159
33Abnormality of the nasal mucosa (HP:0000433)3.14695154
34Absent frontal sinuses (HP:0002688)3.05479462
35Hypoplasia of the uterus (HP:0000013)3.05329431
36Abnormality of the ischium (HP:0003174)3.05112543
37Bladder diverticulum (HP:0000015)3.04763995
38Premature rupture of membranes (HP:0001788)2.99101657
39Enlarged epiphyses (HP:0010580)2.93782314
40Impulsivity (HP:0100710)2.82839625
41Renal dysplasia (HP:0000110)2.82772658
42Overriding aorta (HP:0002623)2.78036916
43Tubular atrophy (HP:0000092)2.75640867
44Bronchiectasis (HP:0002110)2.69679538
45Cerebellar dysplasia (HP:0007033)2.69155720
46Aplasia/Hypoplasia of the earlobes (HP:0009906)2.69102661
47Gonadal dysgenesis (HP:0000133)2.68230330
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.67115299
49Distal lower limb muscle weakness (HP:0009053)2.65999513
50Aplasia involving bones of the extremities (HP:0009825)2.65349893
51Aplasia involving bones of the upper limbs (HP:0009823)2.65349893
52Aplasia of the phalanges of the hand (HP:0009802)2.65349893
53Broad metatarsal (HP:0001783)2.62492308
54Flat cornea (HP:0007720)2.61874291
55Bell-shaped thorax (HP:0001591)2.61062472
56Flattened epiphyses (HP:0003071)2.56422077
57Cone-rod dystrophy (HP:0000548)2.56414448
58Bronchitis (HP:0012387)2.56347240
59Colitis (HP:0002583)2.56191688
60Nephronophthisis (HP:0000090)2.55509601
61Sensory axonal neuropathy (HP:0003390)2.54123776
62Hyperacusis (HP:0010780)2.52133658
63Stomach cancer (HP:0012126)2.50032107
64Renal duplication (HP:0000075)2.46862668
65Abnormality of the renal medulla (HP:0100957)2.46449619
66Hypoplasia of the thymus (HP:0000778)2.43529455
67Abnormal urine output (HP:0012590)2.43459816
68Abnormality of the frontal sinuses (HP:0002687)2.43224775
69Mitral regurgitation (HP:0001653)2.42421045
70Abnormality of the columella (HP:0009929)2.41902309
71Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.39221677
72Bronchomalacia (HP:0002780)2.38309000
73Congenital sensorineural hearing impairment (HP:0008527)2.37071000
74Male infertility (HP:0003251)2.36990281
75Aortic valve stenosis (HP:0001650)2.33362542
76Double outlet right ventricle (HP:0001719)2.33005350
77Congenital malformation of the right heart (HP:0011723)2.33005350
78Male pseudohermaphroditism (HP:0000037)2.32490311
79Glucose intolerance (HP:0000833)2.30645644
80Unilateral renal agenesis (HP:0000122)2.30371964
81Polydipsia (HP:0001959)2.29921455
82Abnormal drinking behavior (HP:0030082)2.29921455
83Aplasia/hypoplasia of the uterus (HP:0008684)2.29561132
84Abnormality of the aortic arch (HP:0012303)2.27612846
85Tubulointerstitial nephritis (HP:0001970)2.24616906
86Adrenal hypoplasia (HP:0000835)2.20228564
87Generalized aminoaciduria (HP:0002909)2.19614033
88Germ cell neoplasia (HP:0100728)2.19328693
89Atonic seizures (HP:0010819)2.17907332
90Occipital encephalocele (HP:0002085)2.16928450
91Abnormality of the distal phalanges of the toes (HP:0010182)2.16844365
92Epiphyseal dysplasia (HP:0002656)2.16597137
93Optic nerve hypoplasia (HP:0000609)2.11651564
94Upper limb muscle weakness (HP:0003484)2.11572048
95Vascular tortuosity (HP:0004948)2.10532133
96Abnormality of renal excretion (HP:0011036)2.08306237
97Type II lissencephaly (HP:0007260)2.06953616
98Ridged nail (HP:0001807)2.05216160
99Retinal dysplasia (HP:0007973)2.05141833
100Insomnia (HP:0100785)2.04961725
101Abnormality of the diencephalon (HP:0010662)2.03987582
102Recurrent sinusitis (HP:0011108)2.02221052
103Truncal obesity (HP:0001956)2.00457108
104Abnormality of dental color (HP:0011073)1.99989565
105Retinal atrophy (HP:0001105)1.99775480
106Progressive sensorineural hearing impairment (HP:0000408)1.99122467
107Turricephaly (HP:0000262)1.98820630
108Persistence of primary teeth (HP:0006335)1.98301234
109Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.98099253
110Polyuria (HP:0000103)1.97686930
111Abnormality of the middle phalanges of the toes (HP:0010183)1.96892301
112Facial shape deformation (HP:0011334)1.95532922
113Potter facies (HP:0002009)1.95532922
114Abnormality of potassium homeostasis (HP:0011042)1.95162822
115Hypoalphalipoproteinemia (HP:0003233)1.94882349
116Progressive cerebellar ataxia (HP:0002073)1.94094632
117Prostate neoplasm (HP:0100787)1.94048502
118Recurrent corneal erosions (HP:0000495)1.93645264
119Emphysema (HP:0002097)1.91101130
120Spondylolisthesis (HP:0003302)1.89512599
121Tubulointerstitial abnormality (HP:0001969)1.88045434
122Alopecia of scalp (HP:0002293)1.87321501
123Hypodontia (HP:0000668)1.86527675
124Stage 5 chronic kidney disease (HP:0003774)1.85257298
125Atrophic scars (HP:0001075)1.85139825
126Spinal rigidity (HP:0003306)1.84826814
127Bulbous nose (HP:0000414)1.83411284
128Reduced antithrombin III activity (HP:0001976)1.82666254
129Hypoplastic toenails (HP:0001800)1.82445873
130Recurrent otitis media (HP:0000403)1.81826335
131Abnormality of the renal cortex (HP:0011035)1.81432190
132Anterior segment dysgenesis (HP:0007700)1.81186304
133Portal hypertension (HP:0001409)1.81067174
134Aortic regurgitation (HP:0001659)1.80820050
135Humeroradial synostosis (HP:0003041)1.80506827
136Synostosis involving the elbow (HP:0003938)1.80506827
137Submucous cleft hard palate (HP:0000176)1.79284283
138Abnormality of the costochondral junction (HP:0000919)1.78776794
139Photophobia (HP:0000613)1.77931481
140Thoracolumbar scoliosis (HP:0002944)1.77316645
141Wormian bones (HP:0002645)1.75483629
142Abnormality of the hepatic vasculature (HP:0006707)1.73675103
143Decreased central vision (HP:0007663)1.72521345
144Short hallux (HP:0010109)1.72203475
145Abnormal glucose tolerance (HP:0001952)1.71884203
146Ventricular fibrillation (HP:0001663)1.71557666
147Congenital, generalized hypertrichosis (HP:0004540)1.70767430
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70752905
149Absent epiphyses (HP:0010577)1.70752905
150Myocardial infarction (HP:0001658)1.70360202
151Widely patent fontanelles and sutures (HP:0004492)1.69863879
152Down-sloping shoulders (HP:0200021)1.68834817
153Atelectasis (HP:0100750)1.68536317
154Type II diabetes mellitus (HP:0005978)1.68522685
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67484707
156Tubulointerstitial fibrosis (HP:0005576)1.66141029
157Hypophosphatemic rickets (HP:0004912)1.65763340
158Protuberant abdomen (HP:0001538)1.65662199
159Recurrent pneumonia (HP:0006532)1.65330344
160Lip pit (HP:0100267)1.63947384
161Abnormal spermatogenesis (HP:0008669)1.63525252
162Bony spicule pigmentary retinopathy (HP:0007737)1.62950622
163Acanthosis nigricans (HP:0000956)1.62626878
164Bowel diverticulosis (HP:0005222)1.61407629
165Orchitis (HP:0100796)1.60114991
166Medial flaring of the eyebrow (HP:0010747)1.59997291
167Abnormality of the gastric mucosa (HP:0004295)1.59855376
168Optic neuritis (HP:0100653)1.59365926
169Retrobulbar optic neuritis (HP:0100654)1.59365926
170Arnold-Chiari malformation (HP:0002308)1.59114043
171Aortic aneurysm (HP:0004942)1.59043554
172Femoral bowing (HP:0002980)1.58428872
173Abnormality of dentin (HP:0010299)1.57766028
174Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.55520960
175Facial cleft (HP:0002006)1.55006850
176Deviation of the hallux (HP:0010051)1.54525292
177Renal cortical cysts (HP:0000803)1.52893354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.49391998
2MAPK155.44108193
3PDK25.14713430
4PDK34.87159354
5PDK44.87159354
6DDR24.13890645
7MARK33.54031087
8TIE13.47405009
9TESK13.19978419
10MAP3K23.01321488
11TGFBR22.82394052
12MAP4K22.76156007
13MAP2K22.41976965
14TLK12.39267929
15MAP3K142.28904400
16PRKD32.25307454
17LATS12.12069367
18NUAK11.94510014
19PLK21.93298572
20BRD41.93114090
21ICK1.88434259
22MAP3K31.81484511
23BMX1.74400910
24MYLK1.67871880
25RPS6KA51.56733956
26INSRR1.54109745
27NLK1.53863539
28PTK2B1.48389216
29MAP3K91.42005962
30STK391.38501369
31CDK121.31094279
32NEK21.26607604
33MAPK71.18878246
34RIPK41.16953098
35ACVR1B1.12517931
36ADRBK21.05974390
37BMPR1B1.03216570
38MAPKAPK51.01626154
39NME11.00122064
40WNK40.98330646
41ZAK0.97769481
42GRK70.96697844
43CDK30.94682745
44NEK60.94501787
45EPHB10.94386794
46MST40.91319234
47KSR20.90560052
48SGK4940.89719467
49SGK2230.89719467
50GRK10.89268094
51PIK3CG0.88586892
52CDK70.87893212
53PINK10.87867491
54DYRK1B0.87328918
55EPHB20.82280690
56VRK10.80997156
57FRK0.79404342
58WNK10.79145523
59MAP2K70.79038144
60PIM20.73748598
61TEC0.73516316
62CDK60.72325934
63EPHA20.72262171
64FER0.72234714
65ARAF0.71306903
66ROCK10.71145404
67STK100.70954382
68GSK3A0.68856203
69STK380.68049286
70MAP3K10.67121683
71PRKG10.65243713
72MAP3K70.64945143
73DMPK0.62591611
74BRAF0.60935911
75RPS6KA10.58565199
76PDK10.58416014
77IRAK10.56871634
78IKBKB0.56820224
79CAMK10.56532078
80TGFBR10.56488897
81MAP2K10.55951051
82TRPM70.55708148
83PTK60.55565805
84RPS6KA20.55088670
85AKT30.53734998
86BCR0.53674071
87MAPKAPK20.52791835
88MST1R0.52231564
89MAPK120.51729040
90STK30.50869985
91TYK20.50352254
92DYRK30.50274235
93MAP3K40.49073799
94CHUK0.48542429
95EPHA30.48524352
96KDR0.47503576
97STK38L0.47147203
98PKN10.46671063
99PRKCQ0.46185782
100PRKAA20.44793928
101MAP3K130.44708782
102MAP3K80.44506740
103MTOR0.43736163
104CASK0.43166582
105PNCK0.42121743
106ERBB30.41681321
107TBK10.40203387
108TSSK60.39005799
109CDK80.37027230
110ITK0.36794551
111PBK0.36114135
112CAMK1G0.35493433
113MUSK0.34812086
114DYRK20.34224205
115GSK3B0.33877356
116HIPK20.33404416
117CDK140.33169410
118PAK40.32770487
119SIK20.32104610
120RPS6KB20.31567679
121PAK20.31273591
122CAMKK20.30695756
123PDGFRB0.30641486
124PDPK10.30270495
125LATS20.30060333
126OBSCN0.29473797
127UHMK10.29278233
128EIF2AK20.24590872
129CDK40.24529154
130IKBKE0.23795077
131IGF1R0.23731671
132MET0.23552754
133MOS0.23545150
134MAP2K60.23530046
135CAMK40.23422638
136PAK10.22723814
137CDK10.22550467
138RPS6KL10.22358544
139RPS6KC10.22358544
140PRKD10.22044117
141BMPR20.21929579
142FGR0.21518044
143CDK20.20790597
144CDK50.20768675
145MAPK40.20615472
146PRKCD0.20351149
147RPS6KA60.20210550
148MAPK80.19925353
149MAPK10.19565908
150CAMK1D0.18581628
151PRKG20.18524334
152INSR0.16967914
153SGK10.16529980
154CDC42BPA0.15631068
155FGFR20.14978305
156TYRO30.14897043
157CSNK1A1L0.13451275
158SGK20.12696406
159MARK20.12429592
160PRKCG0.12287879
161RPS6KA30.11971234
162AKT10.10489394
163CHEK10.10061403
164PRKCB0.09612908
165MAPK100.09503394
166ATM0.09195448

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.52704628
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.95087209
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.71604212
4Olfactory transduction_Homo sapiens_hsa047403.59205416
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.58493241
6Chemical carcinogenesis_Homo sapiens_hsa052043.18900271
7Pentose and glucuronate interconversions_Homo sapiens_hsa000403.13741550
8Butanoate metabolism_Homo sapiens_hsa006502.89996976
9Gap junction_Homo sapiens_hsa045402.86785380
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.58607375
11Hedgehog signaling pathway_Homo sapiens_hsa043402.46017002
12Arginine biosynthesis_Homo sapiens_hsa002201.98705432
13Nitrogen metabolism_Homo sapiens_hsa009101.93765803
14Glycerophospholipid metabolism_Homo sapiens_hsa005641.87131132
15Complement and coagulation cascades_Homo sapiens_hsa046101.83835196
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.83661024
17Systemic lupus erythematosus_Homo sapiens_hsa053221.73905644
18Glutathione metabolism_Homo sapiens_hsa004801.68168349
19Retinol metabolism_Homo sapiens_hsa008301.61802023
20Phagosome_Homo sapiens_hsa041451.56866831
21Taste transduction_Homo sapiens_hsa047421.56208791
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.53498588
23Mineral absorption_Homo sapiens_hsa049781.51648489
24Protein digestion and absorption_Homo sapiens_hsa049741.50889120
25Phenylalanine metabolism_Homo sapiens_hsa003601.50189793
26Alcoholism_Homo sapiens_hsa050341.47219897
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44541399
28Fatty acid degradation_Homo sapiens_hsa000711.42365229
29Fatty acid biosynthesis_Homo sapiens_hsa000611.41762631
30Rheumatoid arthritis_Homo sapiens_hsa053231.37616402
31Apoptosis_Homo sapiens_hsa042101.36718197
32Linoleic acid metabolism_Homo sapiens_hsa005911.35776266
33ABC transporters_Homo sapiens_hsa020101.35465380
34Malaria_Homo sapiens_hsa051441.30732882
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26228202
36Adherens junction_Homo sapiens_hsa045201.20465483
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17939426
38Starch and sucrose metabolism_Homo sapiens_hsa005001.17745936
39Osteoclast differentiation_Homo sapiens_hsa043801.17081391
40Type I diabetes mellitus_Homo sapiens_hsa049401.15563155
41Type II diabetes mellitus_Homo sapiens_hsa049301.15314409
42Allograft rejection_Homo sapiens_hsa053301.14896697
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13117926
44Vitamin B6 metabolism_Homo sapiens_hsa007501.12864826
45Ether lipid metabolism_Homo sapiens_hsa005651.12149590
46ECM-receptor interaction_Homo sapiens_hsa045121.10813678
47Renin secretion_Homo sapiens_hsa049241.09391471
48Autoimmune thyroid disease_Homo sapiens_hsa053201.09098989
49Amphetamine addiction_Homo sapiens_hsa050311.09097278
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08858579
51Legionellosis_Homo sapiens_hsa051341.08643324
52Sulfur metabolism_Homo sapiens_hsa009201.07877114
53Fatty acid metabolism_Homo sapiens_hsa012121.05931495
54Graft-versus-host disease_Homo sapiens_hsa053321.05470740
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04116075
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02984421
57Dorso-ventral axis formation_Homo sapiens_hsa043201.01754339
58Vitamin digestion and absorption_Homo sapiens_hsa049770.99598127
59TNF signaling pathway_Homo sapiens_hsa046680.98114400
60Oocyte meiosis_Homo sapiens_hsa041140.97336191
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94281996
62Sphingolipid metabolism_Homo sapiens_hsa006000.92019615
63Arachidonic acid metabolism_Homo sapiens_hsa005900.91028806
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90806056
65Antigen processing and presentation_Homo sapiens_hsa046120.90161061
66Glucagon signaling pathway_Homo sapiens_hsa049220.89974899
67Propanoate metabolism_Homo sapiens_hsa006400.89799409
68PPAR signaling pathway_Homo sapiens_hsa033200.89786512
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88481843
70RNA transport_Homo sapiens_hsa030130.87388080
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87182468
72Basal cell carcinoma_Homo sapiens_hsa052170.85986909
73African trypanosomiasis_Homo sapiens_hsa051430.84853435
74TGF-beta signaling pathway_Homo sapiens_hsa043500.84831091
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84741180
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84555265
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83126175
78Arginine and proline metabolism_Homo sapiens_hsa003300.82608889
79Staphylococcus aureus infection_Homo sapiens_hsa051500.82362896
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81304755
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81245101
82Toxoplasmosis_Homo sapiens_hsa051450.78387576
83Phototransduction_Homo sapiens_hsa047440.75092802
84Salivary secretion_Homo sapiens_hsa049700.74945169
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74908771
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74763193
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73584198
88Leishmaniasis_Homo sapiens_hsa051400.73464236
89Estrogen signaling pathway_Homo sapiens_hsa049150.73191735
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72802227
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71421948
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71041243
93B cell receptor signaling pathway_Homo sapiens_hsa046620.69805800
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69299367
95Endocytosis_Homo sapiens_hsa041440.69255064
96Circadian rhythm_Homo sapiens_hsa047100.67826458
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65566529
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63900888
99Pertussis_Homo sapiens_hsa051330.63851121
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.62272825
101Tyrosine metabolism_Homo sapiens_hsa003500.61952829
102Cocaine addiction_Homo sapiens_hsa050300.61717867
103MAPK signaling pathway_Homo sapiens_hsa040100.61313292
104Circadian entrainment_Homo sapiens_hsa047130.61215511
105Viral myocarditis_Homo sapiens_hsa054160.60901516
106Pathways in cancer_Homo sapiens_hsa052000.60043309
107Bile secretion_Homo sapiens_hsa049760.59887522
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59205227
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59126937
110Gastric acid secretion_Homo sapiens_hsa049710.58783161
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58611591
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.58429752
113Influenza A_Homo sapiens_hsa051640.57850222
114Wnt signaling pathway_Homo sapiens_hsa043100.57814751
115Inositol phosphate metabolism_Homo sapiens_hsa005620.57125568
116Rap1 signaling pathway_Homo sapiens_hsa040150.56663570
117Tight junction_Homo sapiens_hsa045300.55811300
118Calcium signaling pathway_Homo sapiens_hsa040200.55247803
119Oxytocin signaling pathway_Homo sapiens_hsa049210.54563101
120Prostate cancer_Homo sapiens_hsa052150.53863270
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.53350380
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53115480
123Synaptic vesicle cycle_Homo sapiens_hsa047210.52735730
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52119875
125Salmonella infection_Homo sapiens_hsa051320.51601115
126HIF-1 signaling pathway_Homo sapiens_hsa040660.51564789
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51170095
128Hippo signaling pathway_Homo sapiens_hsa043900.50713864
129Purine metabolism_Homo sapiens_hsa002300.50618228
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50237789
131Morphine addiction_Homo sapiens_hsa050320.49222015
132Melanogenesis_Homo sapiens_hsa049160.48921323
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47811937
134Focal adhesion_Homo sapiens_hsa045100.47798574
135Ras signaling pathway_Homo sapiens_hsa040140.47486998
136Glycerolipid metabolism_Homo sapiens_hsa005610.45947500
137cAMP signaling pathway_Homo sapiens_hsa040240.45684761
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.45280342
139Other glycan degradation_Homo sapiens_hsa005110.44641751
140mRNA surveillance pathway_Homo sapiens_hsa030150.44509327
141Axon guidance_Homo sapiens_hsa043600.43436227
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43126478
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42186926
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41766894
145HTLV-I infection_Homo sapiens_hsa051660.40780948
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.40635667
147Basal transcription factors_Homo sapiens_hsa030220.39730675
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39564356
149Viral carcinogenesis_Homo sapiens_hsa052030.38927431
150Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37768698
151Selenocompound metabolism_Homo sapiens_hsa004500.35268743
152Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34829227
153Fat digestion and absorption_Homo sapiens_hsa049750.33706555
154VEGF signaling pathway_Homo sapiens_hsa043700.31914902
155Glutamatergic synapse_Homo sapiens_hsa047240.29228478
156Nicotine addiction_Homo sapiens_hsa050330.28442939
157Maturity onset diabetes of the young_Homo sapiens_hsa049500.26662132
158Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25809491
159Pyruvate metabolism_Homo sapiens_hsa006200.24831852
160Herpes simplex infection_Homo sapiens_hsa051680.23627290
161Choline metabolism in cancer_Homo sapiens_hsa052310.22843395
162Insulin secretion_Homo sapiens_hsa049110.22491117
163Cholinergic synapse_Homo sapiens_hsa047250.21510365

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