FAM65B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.98574620
2negative regulation of cell killing (GO:0031342)6.21458017
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.21458017
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.73980930
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.69104365
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.69104365
7modulation by symbiont of host immune response (GO:0052553)5.69104365
8positive regulation by symbiont of host defense response (GO:0052509)5.69104365
9modulation by symbiont of host defense response (GO:0052031)5.69104365
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.69104365
11regulation of B cell receptor signaling pathway (GO:0050855)5.29121215
12negative T cell selection (GO:0043383)5.27919641
13negative thymic T cell selection (GO:0045060)5.13952363
14regulation of gamma-delta T cell differentiation (GO:0045586)5.04999651
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.96495517
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.96495517
17regulation of gamma-delta T cell activation (GO:0046643)4.83397919
18leukocyte aggregation (GO:0070486)4.81734801
19cellular response to interleukin-15 (GO:0071350)4.78832755
20macrophage activation involved in immune response (GO:0002281)4.71462228
21response to interleukin-15 (GO:0070672)4.70924981
22antigen processing and presentation of endogenous antigen (GO:0019883)4.67591209
23detection of other organism (GO:0098543)4.64936745
24positive T cell selection (GO:0043368)4.63230598
25B cell receptor signaling pathway (GO:0050853)4.61457611
26interferon-gamma production (GO:0032609)4.60696264
27positive thymic T cell selection (GO:0045059)4.53570301
28detection of molecule of bacterial origin (GO:0032490)4.51725208
29microglial cell activation (GO:0001774)4.40817057
30neutrophil activation involved in immune response (GO:0002283)4.38431355
31T cell migration (GO:0072678)4.36722949
32T cell selection (GO:0045058)4.36721020
33regulation of B cell differentiation (GO:0045577)4.34853456
34detection of bacterium (GO:0016045)4.31264585
35ribosomal small subunit assembly (GO:0000028)4.28177928
36detection of external biotic stimulus (GO:0098581)4.23196063
37thymic T cell selection (GO:0045061)4.22813543
38mature B cell differentiation (GO:0002335)4.21601960
39positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.15317375
40mast cell activation (GO:0045576)4.14838194
41positive regulation of B cell differentiation (GO:0045579)4.11892867
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.11353137
43regulation of interferon-beta biosynthetic process (GO:0045357)4.07642379
44negative regulation of interleukin-12 production (GO:0032695)3.99961141
45negative regulation of leukocyte mediated immunity (GO:0002704)3.97956953
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.92217244
47response to host immune response (GO:0052572)3.92217244
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.91471177
49regulation of isotype switching to IgG isotypes (GO:0048302)3.83839513
50antigen receptor-mediated signaling pathway (GO:0050851)3.82307634
51respiratory burst (GO:0045730)3.81798803
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.80601125
53mast cell activation involved in immune response (GO:0002279)3.79927882
54mast cell degranulation (GO:0043303)3.79927882
55negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.77642400
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.74533415
57response to peptidoglycan (GO:0032494)3.72786765
58neutrophil mediated immunity (GO:0002446)3.72624891
59negative regulation of T cell mediated immunity (GO:0002710)3.71261662
60mature B cell differentiation involved in immune response (GO:0002313)3.68709920
61macrophage activation (GO:0042116)3.67249157
62detection of biotic stimulus (GO:0009595)3.67177461
63regulation of T cell receptor signaling pathway (GO:0050856)3.66556786
64T cell homeostasis (GO:0043029)3.65456694
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.61610313
66response to host (GO:0075136)3.61610313
67response to host defenses (GO:0052200)3.61610313
68T cell receptor signaling pathway (GO:0050852)3.60761791
69leukocyte migration involved in inflammatory response (GO:0002523)3.60737456
70myeloid cell activation involved in immune response (GO:0002275)3.55630406
71regulation of regulatory T cell differentiation (GO:0045589)3.50950782
72immunoglobulin mediated immune response (GO:0016064)3.47105227
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.46837180
74regulation of alpha-beta T cell proliferation (GO:0046640)3.44292081
75regulation of tolerance induction (GO:0002643)3.42021550
76negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.41662995
77negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.40929614
78granulocyte activation (GO:0036230)3.37427608
79negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.35158362
80negative regulation of T-helper cell differentiation (GO:0045623)3.35158362
81myeloid leukocyte mediated immunity (GO:0002444)3.34461187
82negative regulation of erythrocyte differentiation (GO:0045647)3.34418305
83regulation of T cell mediated cytotoxicity (GO:0001914)3.32702008
84production of molecular mediator involved in inflammatory response (GO:0002532)3.30738688
85dendritic cell migration (GO:0036336)3.27239802
86T cell costimulation (GO:0031295)3.22018418
87viral transcription (GO:0019083)3.21986420
88definitive hemopoiesis (GO:0060216)3.21910737
89lymphocyte homeostasis (GO:0002260)3.20016612
90lymphocyte costimulation (GO:0031294)3.18613165
91myeloid dendritic cell activation (GO:0001773)3.18371055
92regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.17653427
93regulation of natural killer cell mediated immunity (GO:0002715)3.17653427
94positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16615868
95negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.14391355
96negative regulation of adaptive immune response (GO:0002820)3.14266846
97positive regulation of mast cell activation (GO:0033005)3.14034988
98CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.13171223
99regulation of T cell tolerance induction (GO:0002664)3.10626142
100megakaryocyte development (GO:0035855)3.09503062
101positive regulation of alpha-beta T cell proliferation (GO:0046641)3.09125516
102negative regulation of lymphocyte mediated immunity (GO:0002707)3.09097051
103regulation of interleukin-2 biosynthetic process (GO:0045076)3.08263176
104regulation of mast cell degranulation (GO:0043304)3.08058366
105activated T cell proliferation (GO:0050798)3.07527037
106T cell differentiation (GO:0030217)3.07259995
107positive regulation of granulocyte differentiation (GO:0030854)3.06439306
108negative regulation of phagocytosis (GO:0050765)3.05969841
109negative regulation of B cell mediated immunity (GO:0002713)3.03994714
110negative regulation of immunoglobulin mediated immune response (GO:0002890)3.03994714
111positive regulation of interleukin-2 production (GO:0032743)3.03128174
112alpha-beta T cell activation (GO:0046631)3.01946347
113cellular response to zinc ion (GO:0071294)3.01042854
114lymphoid progenitor cell differentiation (GO:0002320)2.98782596
115leukocyte cell-cell adhesion (GO:0007159)2.98746815
116cellular extravasation (GO:0045123)2.98264290
117lymph node development (GO:0048535)2.97517130
118translational termination (GO:0006415)2.97130509
119negative regulation of type 2 immune response (GO:0002829)2.96755786
120tolerance induction (GO:0002507)2.96257224
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.94980528
122regulation of mast cell activation (GO:0033003)2.94880562
123response to protozoan (GO:0001562)2.93332140
124negative regulation of T cell receptor signaling pathway (GO:0050860)2.92976180
125T cell proliferation (GO:0042098)2.92969422
126leukocyte homeostasis (GO:0001776)2.92264490
127defense response to protozoan (GO:0042832)2.89620254
128NIK/NF-kappaB signaling (GO:0038061)2.88651269
129interferon-gamma-mediated signaling pathway (GO:0060333)2.86529240
130positive regulation of isotype switching (GO:0045830)2.85913878
131B cell homeostasis (GO:0001782)2.84527934
132Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84449826
133neutrophil activation (GO:0042119)2.82790086
134antigen processing and presentation via MHC class Ib (GO:0002475)2.82054249
135natural killer cell activation (GO:0030101)2.81791757
136alpha-beta T cell differentiation (GO:0046632)2.81294075
137immune response-activating cell surface receptor signaling pathway (GO:0002429)2.79221401
138response to type I interferon (GO:0034340)2.78945397
139positive regulation of DNA recombination (GO:0045911)2.76368544
140B cell activation (GO:0042113)2.75279576
141positive regulation of B cell activation (GO:0050871)2.74841430
142B cell differentiation (GO:0030183)2.74495810
143type I interferon signaling pathway (GO:0060337)2.74442035
144cellular response to type I interferon (GO:0071357)2.74442035
145T cell activation (GO:0042110)2.73613495
146positive regulation of tolerance induction (GO:0002645)2.73441190
147lymphocyte differentiation (GO:0030098)2.72411543
148leukocyte degranulation (GO:0043299)2.70708640
149dendritic cell chemotaxis (GO:0002407)2.70359869
150B cell proliferation (GO:0042100)2.67817435
151T cell lineage commitment (GO:0002360)2.66127206
152positive regulation of B cell proliferation (GO:0030890)2.65630342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.20241214
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.74305885
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.59418182
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.13812098
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.85728587
6SCL_19346495_ChIP-Seq_HPC-7_Human3.53460362
7RUNX_20019798_ChIP-Seq_JUKART_Human3.46918521
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.44058024
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.21030526
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.09850269
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.06659920
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.97800730
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.94901812
14MYC_22102868_ChIP-Seq_BL_Human2.92583945
15* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.87679787
16* MYB_26560356_Chip-Seq_TH2_Human2.70345910
17EZH2_22144423_ChIP-Seq_EOC_Human2.62640581
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.51987956
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.49228746
20VDR_21846776_ChIP-Seq_THP-1_Human2.44855300
21MAF_26560356_Chip-Seq_TH1_Human2.44549920
22* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38595428
23* IRF8_27001747_Chip-Seq_BMDM_Mouse2.35385512
24MYB_26560356_Chip-Seq_TH1_Human2.33210349
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.31705778
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24677354
27UTX_26944678_Chip-Seq_JUKART_Human2.24499197
28SPI1_23547873_ChIP-Seq_NB4_Human2.18821081
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18721343
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18657296
31SMAD_19615063_ChIP-ChIP_OVARY_Human2.17950624
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13194970
33VDR_24763502_ChIP-Seq_THP-1_Human1.99345703
34* RUNX1_22412390_ChIP-Seq_EML_Mouse1.97996989
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94906540
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91669766
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90133167
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84261076
39SPI1_23127762_ChIP-Seq_K562_Human1.80587318
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76065265
41TCF7_22412390_ChIP-Seq_EML_Mouse1.71958185
42MAF_26560356_Chip-Seq_TH2_Human1.69613355
43* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68744138
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66868227
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64490276
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.58022694
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54522128
48GATA3_27048872_Chip-Seq_THYMUS_Human1.54422499
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47705250
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47006448
51E2F7_22180533_ChIP-Seq_HELA_Human1.42428740
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42370588
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40059983
54* PU_27001747_Chip-Seq_BMDM_Mouse1.34456354
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32576716
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29512351
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29055580
58CIITA_25753668_ChIP-Seq_RAJI_Human1.27240623
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.26334104
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21867119
61* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21565651
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21510679
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20927799
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19726311
65* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19541286
66GATA1_22025678_ChIP-Seq_K562_Human1.12444337
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12298245
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10119041
69GATA1_19941826_ChIP-Seq_K562_Human1.09788981
70KDM2B_26808549_Chip-Seq_DND41_Human1.09373714
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.09166885
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08466756
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06976934
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04416302
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03940710
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03762143
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02139802
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00565209
79* SMRT_27268052_Chip-Seq_Bcells_Human0.99752690
80* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98627890
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98125888
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97047170
83VDR_24787735_ChIP-Seq_THP-1_Human0.94682914
84* GATA3_26560356_Chip-Seq_TH2_Human0.94676003
85KDM2B_26808549_Chip-Seq_JURKAT_Human0.94418574
86FLI1_27457419_Chip-Seq_LIVER_Mouse0.94134095
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89295474
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86568063
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86328689
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85271054
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83138974
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82261047
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81009156
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80865691
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79792142
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79353137
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78787911
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78353169
99JARID2_20064375_ChIP-Seq_MESCs_Mouse0.77214687
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76782430
101RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76151875
102* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75968622
103GATA3_26560356_Chip-Seq_TH1_Human0.75916091
104SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.74415131
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73099597
106KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.71748364
107* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71230843
108ETS1_22383799_ChIP-Seq_G1ME_Mouse0.70336535
109TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.70083256
110DROSHA_22980978_ChIP-Seq_HELA_Human0.69443193
111ELK1_19687146_ChIP-ChIP_HELA_Human0.69141164
112CTCF_27219007_Chip-Seq_ERYTHROID_Human0.68458744
113BCL6_27268052_Chip-Seq_Bcells_Human0.68400291
114FOXP3_21729870_ChIP-Seq_TREG_Human0.68290168
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68109509
116NFE2_27457419_Chip-Seq_LIVER_Mouse0.66463725
117GATA2_21666600_ChIP-Seq_HMVEC_Human0.65898630
118* VDR_23849224_ChIP-Seq_CD4+_Human0.65378992
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65003894
120GATA2_19941826_ChIP-Seq_K562_Human0.64953201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.98426385
2MP0001835_abnormal_antigen_presentation3.75201444
3MP0005671_abnormal_response_to3.54993700
4MP0001800_abnormal_humoral_immune3.20831832
5MP0000685_abnormal_immune_system3.08740312
6MP0001790_abnormal_immune_system2.84777679
7MP0005387_immune_system_phenotype2.84777679
8MP0009785_altered_susceptibility_to2.84219624
9MP0005000_abnormal_immune_tolerance2.79559358
10MP0002420_abnormal_adaptive_immunity2.78989344
11MP0005174_abnormal_tail_pigmentation2.77456564
12MP0001819_abnormal_immune_cell2.75132861
13MP0002452_abnormal_antigen_presenting2.73755148
14MP0002398_abnormal_bone_marrow2.66791339
15MP0002723_abnormal_immune_serum2.66329633
16MP0002396_abnormal_hematopoietic_system2.50213228
17MP0005025_abnormal_response_to2.46556871
18MP0003436_decreased_susceptibility_to2.39604950
19MP0000716_abnormal_immune_system2.33880013
20MP0003303_peritoneal_inflammation2.30345502
21MP0002148_abnormal_hypersensitivity_rea2.22341828
22MP0002419_abnormal_innate_immunity2.21513041
23MP0005464_abnormal_platelet_physiology2.14227271
24MP0000689_abnormal_spleen_morphology2.09601372
25MP0002722_abnormal_immune_system2.05987491
26MP0002166_altered_tumor_susceptibility2.04876844
27MP0000703_abnormal_thymus_morphology2.03651604
28MP0000015_abnormal_ear_pigmentation2.03367178
29MP0003724_increased_susceptibility_to1.97744217
30MP0001873_stomach_inflammation1.96824299
31MP0004808_abnormal_hematopoietic_stem1.95183222
32MP0005409_darkened_coat_color1.94376280
33MP0009333_abnormal_splenocyte_physiolog1.93390814
34MP0005075_abnormal_melanosome_morpholog1.91426944
35MP0002429_abnormal_blood_cell1.89310718
36MP0002405_respiratory_system_inflammati1.87654223
37MP0004510_myositis1.85314562
38MP0010155_abnormal_intestine_physiology1.83444257
39MP0002006_tumorigenesis1.75355814
40MP0003866_abnormal_defecation1.74062499
41MP0004381_abnormal_hair_follicle1.73152761
42MP0004883_abnormal_blood_vessel1.71566221
43MP0000465_gastrointestinal_hemorrhage1.70925010
44MP0003191_abnormal_cellular_cholesterol1.62467583
45MP0003172_abnormal_lysosome_physiology1.61527249
46MP0001853_heart_inflammation1.53718188
47MP0001188_hyperpigmentation1.51883470
48MP0001845_abnormal_inflammatory_respons1.51850198
49MP0002095_abnormal_skin_pigmentation1.51007449
50MP0009379_abnormal_foot_pigmentation1.49686296
51MP0005397_hematopoietic_system_phenotyp1.44624652
52MP0001545_abnormal_hematopoietic_system1.44624652
53MP0001986_abnormal_taste_sensitivity1.43804986
54MP0005451_abnormal_body_composition1.37020923
55MP0002933_joint_inflammation1.24812079
56MP0003880_abnormal_central_pattern1.24505510
57MP0000858_altered_metastatic_potential1.22029447
58MP0009278_abnormal_bone_marrow1.21007534
59MP0006292_abnormal_olfactory_placode1.20397913
60MP0004130_abnormal_muscle_cell1.19538840
61MP0000490_abnormal_crypts_of1.16483730
62MP0006082_CNS_inflammation1.14639268
63MP0005164_abnormal_response_to1.13068802
64MP0003690_abnormal_glial_cell1.10222089
65MP0002009_preneoplasia1.07854093
66MP0004947_skin_inflammation1.06561653
67MP0004859_abnormal_synaptic_plasticity1.04778268
68MP0003136_yellow_coat_color0.98185473
69MP0003787_abnormal_imprinting0.96926267
70MP0001663_abnormal_digestive_system0.92570699
71MP0008469_abnormal_protein_level0.91992804
72MP0003183_abnormal_peptide_metabolism0.91731472
73MP0009764_decreased_sensitivity_to0.91542918
74MP0002132_abnormal_respiratory_system0.91246264
75MP0005310_abnormal_salivary_gland0.90755963
76MP0001533_abnormal_skeleton_physiology0.90461832
77MP0008569_lethality_at_weaning0.90170087
78MP0002735_abnormal_chemical_nociception0.89106938
79MP0002822_catalepsy0.85429250
80MP0003221_abnormal_cardiomyocyte_apopto0.85007734
81MP0000569_abnormal_digit_pigmentation0.84142482
82MP0002277_abnormal_respiratory_mucosa0.83371087
83MP0003300_gastrointestinal_ulcer0.82694340
84MP0002019_abnormal_tumor_incidence0.81519795
85MP0000372_irregular_coat_pigmentation0.79786826
86MP0004484_altered_response_of0.79254241
87MP0009763_increased_sensitivity_to0.78314918
88MP0001968_abnormal_touch/_nociception0.75953932
89MP0009745_abnormal_behavioral_response0.74394519
90MP0003448_altered_tumor_morphology0.74334933
91MP0008874_decreased_physiological_sensi0.72763868
92MP0003075_altered_response_to0.72678445
93MP0002332_abnormal_exercise_endurance0.68454566
94MP0005390_skeleton_phenotype0.65975077
95MP0002138_abnormal_hepatobiliary_system0.65415066
96MP0000249_abnormal_blood_vessel0.63060506
97MP0003045_fibrosis0.62744698
98MP0002998_abnormal_bone_remodeling0.61704667
99MP0000604_amyloidosis0.61436706
100MP0008260_abnormal_autophagy0.61349030
101MP0008058_abnormal_DNA_repair0.61037596
102MP0003635_abnormal_synaptic_transmissio0.60347349
103MP0002133_abnormal_respiratory_system0.54670319
104MP0005388_respiratory_system_phenotype0.54670319
105MP0008004_abnormal_stomach_pH0.54174242
106MP0005423_abnormal_somatic_nervous0.54064264
107MP0003828_pulmonary_edema0.53481854
108MP0005376_homeostasis/metabolism_phenot0.53357692
109MP0002876_abnormal_thyroid_physiology0.52556240
110MP0002736_abnormal_nociception_after0.52423738
111MP0001851_eye_inflammation0.51418413
112MP0003091_abnormal_cell_migration0.50057904
113MP0001919_abnormal_reproductive_system0.49454847
114MP0002693_abnormal_pancreas_physiology0.49205651
115MP0000681_abnormal_thyroid_gland0.49063710
116MP0003795_abnormal_bone_structure0.49057006
117MP0003252_abnormal_bile_duct0.47774200
118MP0002928_abnormal_bile_duct0.47135011
119MP0009765_abnormal_xenobiotic_induced0.46304210
120MP0005645_abnormal_hypothalamus_physiol0.46027648
121MP0005166_decreased_susceptibility_to0.45996480
122MP0003656_abnormal_erythrocyte_physiolo0.43069998
123MP0008995_early_reproductive_senescence0.42891729
124MP0001501_abnormal_sleep_pattern0.40950669

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.08233887
2Chronic otitis media (HP:0000389)4.66068421
3Panhypogammaglobulinemia (HP:0003139)4.44662783
4Recurrent abscess formation (HP:0002722)4.40383103
5Meningitis (HP:0001287)4.38083027
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.26911906
7Chronic mucocutaneous candidiasis (HP:0002728)4.26078011
8Recurrent cutaneous fungal infections (HP:0011370)4.26078011
9IgM deficiency (HP:0002850)4.24301430
10Recurrent fungal infections (HP:0002841)4.17320116
11Recurrent bronchitis (HP:0002837)4.13474635
12Elevated erythrocyte sedimentation rate (HP:0003565)4.07053104
13Stomatitis (HP:0010280)3.99953256
14T lymphocytopenia (HP:0005403)3.91350321
15Recurrent viral infections (HP:0004429)3.85875694
16Mediastinal lymphadenopathy (HP:0100721)3.85340845
17Eczematoid dermatitis (HP:0000976)3.83908384
18Abnormality of T cell number (HP:0011839)3.77615374
19Myositis (HP:0100614)3.73882573
20Cellulitis (HP:0100658)3.73622503
21Recurrent bacterial skin infections (HP:0005406)3.68406496
22Chronic obstructive pulmonary disease (HP:0006510)3.60323808
23Obstructive lung disease (HP:0006536)3.60323808
24Prolonged bleeding time (HP:0003010)3.57167812
25Recurrent sinusitis (HP:0011108)3.37260386
26Abnormality of T cells (HP:0002843)3.37051501
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.33306209
28Hypochromic microcytic anemia (HP:0004840)3.33105396
29Recurrent skin infections (HP:0001581)3.24124240
30IgG deficiency (HP:0004315)3.16409163
31Urticaria (HP:0001025)3.15408682
32Gingival bleeding (HP:0000225)3.14988983
33Thrombocytosis (HP:0001894)3.09952132
34Nasal polyposis (HP:0100582)3.08617980
35Chronic sinusitis (HP:0011109)3.06869438
36Lymphopenia (HP:0001888)3.04014998
37Thyroiditis (HP:0100646)3.02104822
38Peritonitis (HP:0002586)3.01253564
39Abnormality of the fingertips (HP:0001211)2.97411792
40Inflammation of the large intestine (HP:0002037)2.96558327
41Hypochromic anemia (HP:0001931)2.96046368
42Verrucae (HP:0200043)2.95004016
43Papilloma (HP:0012740)2.95004016
44Encephalitis (HP:0002383)2.94356816
45Optic neuritis (HP:0100653)2.93550221
46Retrobulbar optic neuritis (HP:0100654)2.93550221
47Vasculitis (HP:0002633)2.93071807
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.92888694
49Petechiae (HP:0000967)2.82047243
50Gastrointestinal inflammation (HP:0004386)2.79704065
51Pulmonary embolism (HP:0002204)2.78860186
52Anorexia (HP:0002039)2.77463420
53Episodic fever (HP:0001954)2.74870069
54Abnormality of the nasal mucosa (HP:0000433)2.69807631
55Epistaxis (HP:0000421)2.64720929
56Abnormality of T cell physiology (HP:0011840)2.64523279
57Hemoptysis (HP:0002105)2.62645347
58Severe combined immunodeficiency (HP:0004430)2.59854348
59Abnormality of the prostate (HP:0008775)2.59198120
60B lymphocytopenia (HP:0010976)2.58072476
61Abnormality of B cell number (HP:0010975)2.58072476
62Increased IgM level (HP:0003496)2.55419267
63Gastrointestinal stroma tumor (HP:0100723)2.50572652
64Colitis (HP:0002583)2.50008752
65Orchitis (HP:0100796)2.48819392
66Pustule (HP:0200039)2.47385959
67Abnormality of eosinophils (HP:0001879)2.46722280
68Slow saccadic eye movements (HP:0000514)2.39589723
69Abnormality of the pleura (HP:0002103)2.36328360
70Gangrene (HP:0100758)2.36063357
71Pulmonary infiltrates (HP:0002113)2.33786455
72Leukocytosis (HP:0001974)2.32260732
73Viral hepatitis (HP:0006562)2.31735904
74Eosinophilia (HP:0001880)2.30357817
75Combined immunodeficiency (HP:0005387)2.28567672
76Abnormality of the peritoneum (HP:0002585)2.27373492
77Cheilitis (HP:0100825)2.26885210
78Chronic diarrhea (HP:0002028)2.26870869
79Keratoconjunctivitis sicca (HP:0001097)2.24334970
80Bronchitis (HP:0012387)2.23566823
81Subacute progressive viral hepatitis (HP:0006572)2.23013522
82Lymphoma (HP:0002665)2.22306430
83Spontaneous hematomas (HP:0007420)2.21984264
84Granulocytopenia (HP:0001913)2.19735509
85Recurrent gram-negative bacterial infections (HP:0005420)2.18380696
86Keratitis (HP:0000491)2.18285727
87Autoimmune hemolytic anemia (HP:0001890)2.17775983
88Acute hepatic failure (HP:0006554)2.13553102
89Abnormal hair whorl (HP:0010721)2.13102662
90Increased IgE level (HP:0003212)2.12715357
91Abnormality of the endocardium (HP:0004306)2.12667294
92Abnormal platelet volume (HP:0011876)2.11460062
93Abnormality of macrophages (HP:0004311)2.10956311
94Stomach cancer (HP:0012126)2.09692280
95Arterial thrombosis (HP:0004420)2.09570195
96Hemiplegia (HP:0002301)2.09114102
97Osteomyelitis (HP:0002754)2.08874743
98Recurrent pneumonia (HP:0006532)2.07154432
99Chest pain (HP:0100749)2.06866887
100Keratoconjunctivitis (HP:0001096)2.05667171
101Hypergammaglobulinemia (HP:0010702)2.05113474
102Reticulocytopenia (HP:0001896)2.04515223
103Glomerulopathy (HP:0100820)2.02438920
104Vertigo (HP:0002321)2.01667573
105Type I transferrin isoform profile (HP:0003642)2.01503676
106Sepsis (HP:0100806)2.00532230
107Aplastic anemia (HP:0001915)1.99400760
108Gastrointestinal infarctions (HP:0005244)1.99184171
109Papilledema (HP:0001085)1.97469749
110Abnormality of cells of the erythroid lineage (HP:0012130)1.97108507
111Reduced antithrombin III activity (HP:0001976)1.96854805
112Skin ulcer (HP:0200042)1.96699117
113Autoimmune thrombocytopenia (HP:0001973)1.96301787
114Impaired platelet aggregation (HP:0003540)1.96071380
115Abnormal platelet function (HP:0011869)1.96071380
116Microcytic anemia (HP:0001935)1.95854436
117Recurrent lower respiratory tract infections (HP:0002783)1.95784308
118Skin rash (HP:0000988)1.94977404
119Gingivitis (HP:0000230)1.94864755
120Absent frontal sinuses (HP:0002688)1.91445672
121Clubbing of toes (HP:0100760)1.90932209
122Recurrent otitis media (HP:0000403)1.90743877
123Dry hair (HP:0011359)1.89508366
124Abnormal number of erythroid precursors (HP:0012131)1.88323896
125Poikiloderma (HP:0001029)1.88061804
126Joint swelling (HP:0001386)1.86788023
127Amyloidosis (HP:0011034)1.84713709
128Neoplasm of the tracheobronchial system (HP:0100552)1.81092325
129Acne (HP:0001061)1.80192255
130Polyneuropathy (HP:0001271)1.72641348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.01580591
2TXK4.07772639
3GRK62.68529361
4TEC2.64798152
5BTK2.39756280
6JAK32.38920827
7IRAK42.38065697
8FES2.27163540
9RIPK42.23669248
10MAP3K142.22859848
11NME22.22679331
12SYK2.11630853
13ITK2.07862704
14NLK2.05549696
15IKBKE2.03287845
16CLK11.95872353
17KIT1.87225995
18MAP3K121.85023501
19ZAP701.84202293
20TNIK1.81878534
21EPHB11.80290248
22TLK11.79090441
23MAP3K131.72622515
24MKNK21.71959857
25ERN11.66849463
26FGR1.65540873
27TYK21.62173837
28CASK1.61030850
29STK101.58239770
30BLK1.56018346
31LCK1.54252975
32HCK1.52508648
33SIK21.49842072
34IRAK31.32359304
35MAP3K31.30939402
36TNK21.30082150
37JAK11.29994294
38IKBKB1.27235436
39CSK1.24097073
40LYN1.18402240
41PRKD21.14968436
42FGFR31.14116310
43PIM11.11697380
44TBK11.10438347
45MAP3K111.08470821
46KSR21.05238806
47MAP3K11.04182570
48MUSK1.01980702
49CSF1R1.01917457
50PIK3CG0.99669690
51MAPK120.99223069
52TGFBR20.97990371
53PRKCQ0.95039997
54MAP2K70.93786564
55MAPK130.93077454
56MARK30.91647421
57PTK2B0.91493896
58SIK30.89977330
59MAP3K20.88896236
60FGFR40.88739022
61MAP3K100.85587355
62HIPK20.83108189
63PRPF4B0.81968634
64MAP3K60.81361204
65MKNK10.75176812
66CAMKK10.74074482
67IRAK20.73448074
68MAPK40.72568326
69BMPR20.71374389
70ADRBK20.70504550
71LRRK20.69546927
72MAP3K70.69295490
73JAK20.69042139
74PTK60.68295080
75MAP2K30.68184338
76EEF2K0.67672072
77WNK10.65896574
78CDK190.64082059
79DYRK1B0.63670880
80PRKCH0.63034769
81MST40.62430689
82EIF2AK30.61924878
83CAMK10.61176880
84YES10.60693082
85MAP2K40.58747095
86FRK0.57793597
87TAOK30.54851981
88IRAK10.53318509
89MAP3K50.52831555
90TRPM70.52024957
91PDPK10.49995185
92SGK2230.49504526
93SGK4940.49504526
94MAPK110.49112829
95MAP2K60.49092713
96RPS6KA60.48833804
97MARK20.46554088
98KSR10.45210433
99STK110.44050578
100CHUK0.43631666
101RET0.42405080
102NTRK30.42285278
103RPS6KL10.42170200
104RPS6KC10.42170200
105EPHA30.41702536
106GRK50.41510030
107MAPK70.40505265
108PDK10.40436559
109CDC42BPA0.39857633
110GRK70.39638453
111CAMKK20.38598328
112SGK20.37956722
113CAMK40.37090327
114SGK30.36505369
115RAF10.35879491
116RPS6KA40.34400353
117STK40.33299474
118CDK40.33217847
119FYN0.32704826
120MATK0.32595365
121TAOK10.32469460
122PRKCD0.32438075
123TAOK20.30394860
124CCNB10.30121928
125PRKCZ0.30002735
126CDK90.29033988
127PRKG20.28265327
128DAPK10.27601829
129STK380.27551001
130SRPK10.25648236

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.18330509
2B cell receptor signaling pathway_Homo sapiens_hsa046622.52732314
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.44613257
4Staphylococcus aureus infection_Homo sapiens_hsa051502.36183807
5T cell receptor signaling pathway_Homo sapiens_hsa046602.27952791
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.20403711
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.15834548
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05536506
9Leishmaniasis_Homo sapiens_hsa051402.02771652
10Measles_Homo sapiens_hsa051622.00429917
11Ribosome_Homo sapiens_hsa030102.00420521
12Hematopoietic cell lineage_Homo sapiens_hsa046401.98552214
13Osteoclast differentiation_Homo sapiens_hsa043801.87815999
14Graft-versus-host disease_Homo sapiens_hsa053321.75544132
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66680357
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65463989
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58544453
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.45973354
19Allograft rejection_Homo sapiens_hsa053301.45749393
20Chemokine signaling pathway_Homo sapiens_hsa040621.43938799
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39921723
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39416657
23Acute myeloid leukemia_Homo sapiens_hsa052211.35219705
24Antigen processing and presentation_Homo sapiens_hsa046121.34748159
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34050290
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28465576
27Legionellosis_Homo sapiens_hsa051341.25872824
28Herpes simplex infection_Homo sapiens_hsa051681.24764494
29Platelet activation_Homo sapiens_hsa046111.23333276
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23062750
31Hepatitis B_Homo sapiens_hsa051611.21233703
32Olfactory transduction_Homo sapiens_hsa047401.14039110
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12288793
34Phagosome_Homo sapiens_hsa041451.09206470
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.09094468
36Tuberculosis_Homo sapiens_hsa051521.03227818
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02606613
38TNF signaling pathway_Homo sapiens_hsa046680.99075529
39Morphine addiction_Homo sapiens_hsa050320.97302968
40Influenza A_Homo sapiens_hsa051640.97054061
41Shigellosis_Homo sapiens_hsa051310.95466063
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93592996
43Dorso-ventral axis formation_Homo sapiens_hsa043200.92143632
44Toxoplasmosis_Homo sapiens_hsa051450.91596262
45Autoimmune thyroid disease_Homo sapiens_hsa053200.90073847
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89431895
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88074491
48Renal cell carcinoma_Homo sapiens_hsa052110.87226570
49Base excision repair_Homo sapiens_hsa034100.84782999
50Non-small cell lung cancer_Homo sapiens_hsa052230.83412149
51Fanconi anemia pathway_Homo sapiens_hsa034600.83393762
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83026598
53Pertussis_Homo sapiens_hsa051330.82874531
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82080356
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81994263
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.81923317
57Asthma_Homo sapiens_hsa053100.80400418
58Non-homologous end-joining_Homo sapiens_hsa034500.80063410
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79227726
60Endometrial cancer_Homo sapiens_hsa052130.78767711
61Homologous recombination_Homo sapiens_hsa034400.77990996
62Apoptosis_Homo sapiens_hsa042100.76587540
63Type I diabetes mellitus_Homo sapiens_hsa049400.75741904
64Pancreatic cancer_Homo sapiens_hsa052120.75672036
65Colorectal cancer_Homo sapiens_hsa052100.75559073
66Salmonella infection_Homo sapiens_hsa051320.75434460
67Long-term potentiation_Homo sapiens_hsa047200.74965922
68Chronic myeloid leukemia_Homo sapiens_hsa052200.74532997
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74490933
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74367163
71Endocytosis_Homo sapiens_hsa041440.69811449
72African trypanosomiasis_Homo sapiens_hsa051430.69698257
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68965891
74Viral myocarditis_Homo sapiens_hsa054160.68872115
75HTLV-I infection_Homo sapiens_hsa051660.68792903
76DNA replication_Homo sapiens_hsa030300.68515412
77Nicotine addiction_Homo sapiens_hsa050330.68347549
78Malaria_Homo sapiens_hsa051440.67952576
79Prolactin signaling pathway_Homo sapiens_hsa049170.67702238
80Regulation of autophagy_Homo sapiens_hsa041400.65964844
81Epstein-Barr virus infection_Homo sapiens_hsa051690.65700602
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65178836
83Hepatitis C_Homo sapiens_hsa051600.63986902
84mTOR signaling pathway_Homo sapiens_hsa041500.63940533
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63852648
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62546135
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62506780
88Notch signaling pathway_Homo sapiens_hsa043300.61671997
89Viral carcinogenesis_Homo sapiens_hsa052030.61619991
90GnRH signaling pathway_Homo sapiens_hsa049120.60693580
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59859631
92VEGF signaling pathway_Homo sapiens_hsa043700.59339397
93Salivary secretion_Homo sapiens_hsa049700.59147643
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58002589
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57329497
96Rheumatoid arthritis_Homo sapiens_hsa053230.57017175
97MAPK signaling pathway_Homo sapiens_hsa040100.56937813
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56459866
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56291901
100Type II diabetes mellitus_Homo sapiens_hsa049300.55806748
101Glutamatergic synapse_Homo sapiens_hsa047240.55545785
102Cholinergic synapse_Homo sapiens_hsa047250.55343494
103Circadian entrainment_Homo sapiens_hsa047130.54340083
104Insulin resistance_Homo sapiens_hsa049310.53617045
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.53442060
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.52558519
107ErbB signaling pathway_Homo sapiens_hsa040120.52557312
108Calcium signaling pathway_Homo sapiens_hsa040200.52292163
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.51847151
110Inositol phosphate metabolism_Homo sapiens_hsa005620.51019620
111FoxO signaling pathway_Homo sapiens_hsa040680.50961765
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50513310
113p53 signaling pathway_Homo sapiens_hsa041150.49981846
114Spliceosome_Homo sapiens_hsa030400.47470098
115Rap1 signaling pathway_Homo sapiens_hsa040150.46013544
116Prostate cancer_Homo sapiens_hsa052150.44711950
117HIF-1 signaling pathway_Homo sapiens_hsa040660.44183623
118Long-term depression_Homo sapiens_hsa047300.43994541
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43594846
120Ras signaling pathway_Homo sapiens_hsa040140.42830123
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.42590064
122cAMP signaling pathway_Homo sapiens_hsa040240.41841392
123Oxytocin signaling pathway_Homo sapiens_hsa049210.40868422
124Other glycan degradation_Homo sapiens_hsa005110.40330868
125Taste transduction_Homo sapiens_hsa047420.40140026
126Choline metabolism in cancer_Homo sapiens_hsa052310.40057612
127Glioma_Homo sapiens_hsa052140.39905961
128Mismatch repair_Homo sapiens_hsa034300.39725447
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38472906

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