FAM50A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the FAM50 family. The encoded protein is highly conserved in length and sequence across different species. It is a basic protein containing a nuclear localization signal, and may function as a DNA-binding protein or a transcriptional factor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.46527514
2COPI coating of Golgi vesicle (GO:0048205)5.46527514
3protein retention in ER lumen (GO:0006621)5.13419369
4formation of translation preinitiation complex (GO:0001731)5.12896501
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.92934280
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.84542640
7protein localization to endosome (GO:0036010)4.63724835
8barbed-end actin filament capping (GO:0051016)4.60057999
9maturation of SSU-rRNA (GO:0030490)4.46103824
10proteasome assembly (GO:0043248)4.40354680
11DNA strand elongation involved in DNA replication (GO:0006271)4.30564788
12protein maturation by protein folding (GO:0022417)4.26327955
13DNA deamination (GO:0045006)4.25714981
14ribosomal small subunit biogenesis (GO:0042274)4.24518219
15viral transcription (GO:0019083)4.11832480
16regulation of early endosome to late endosome transport (GO:2000641)4.09917936
17telomere maintenance via semi-conservative replication (GO:0032201)4.07770471
18DNA strand elongation (GO:0022616)4.07555154
19DNA replication checkpoint (GO:0000076)4.02937760
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.02808900
21ribosomal small subunit assembly (GO:0000028)4.02018445
22translational termination (GO:0006415)4.00825032
23skin morphogenesis (GO:0043589)3.98592776
24DNA replication initiation (GO:0006270)3.89353715
25translational initiation (GO:0006413)3.77606475
26nucleobase biosynthetic process (GO:0046112)3.76334834
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.71470826
28ribonucleoprotein complex biogenesis (GO:0022613)3.68505075
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67699808
30telomere maintenance via recombination (GO:0000722)3.66959231
31cotranslational protein targeting to membrane (GO:0006613)3.65443047
32ribosome biogenesis (GO:0042254)3.65237632
33ribosome assembly (GO:0042255)3.64920397
34DNA unwinding involved in DNA replication (GO:0006268)3.63199798
35protein targeting to ER (GO:0045047)3.63175941
36purine nucleobase biosynthetic process (GO:0009113)3.58503208
37translational elongation (GO:0006414)3.58161346
38glycosphingolipid catabolic process (GO:0046479)3.56304329
39ribosomal large subunit biogenesis (GO:0042273)3.47249507
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45903210
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.44496392
42mitotic recombination (GO:0006312)3.43060247
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43006747
44protein localization to endoplasmic reticulum (GO:0070972)3.42806392
45negative regulation of ligase activity (GO:0051352)3.42407453
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.42407453
47regulation of mammary gland epithelial cell proliferation (GO:0033599)3.42344761
48protein localization to kinetochore (GO:0034501)3.42337862
49GDP-mannose metabolic process (GO:0019673)3.40852195
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39415313
51glucose 6-phosphate metabolic process (GO:0051156)3.39362627
52rRNA processing (GO:0006364)3.38961373
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38870599
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33187585
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33113984
56cullin deneddylation (GO:0010388)3.30885997
57endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.28705463
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.28531450
59termination of RNA polymerase III transcription (GO:0006386)3.28531450
60pentose-phosphate shunt (GO:0006098)3.26874812
61intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26620366
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26620366
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.25959305
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25247875
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25247875
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25247875
67translation (GO:0006412)3.25123525
68rRNA metabolic process (GO:0016072)3.24727916
69mitotic nuclear envelope reassembly (GO:0007084)3.24352811
70nuclear envelope reassembly (GO:0031468)3.24352811
71glycolipid catabolic process (GO:0019377)3.24346371
72protein deneddylation (GO:0000338)3.23573001
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21114894
74signal transduction involved in DNA damage checkpoint (GO:0072422)3.21114894
75telomere maintenance via telomere lengthening (GO:0010833)3.20908807
76viral life cycle (GO:0019058)3.20678250
77mitotic metaphase plate congression (GO:0007080)3.20638874
78antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.18521124
79nucleotide-excision repair, DNA gap filling (GO:0006297)3.16595630
80signal transduction involved in cell cycle checkpoint (GO:0072395)3.13981528
81cellular protein complex disassembly (GO:0043624)3.09956845
82modulation by symbiont of host cellular process (GO:0044068)3.09661778
83transcription-coupled nucleotide-excision repair (GO:0006283)3.09171885
84G1/S transition of mitotic cell cycle (GO:0000082)3.06608847
85cell cycle G1/S phase transition (GO:0044843)3.06608847
86viral mRNA export from host cell nucleus (GO:0046784)3.05957808
87DNA replication-dependent nucleosome assembly (GO:0006335)3.03406692
88DNA replication-dependent nucleosome organization (GO:0034723)3.03406692
89basement membrane organization (GO:0071711)3.02163908
90vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.01978773
91spliceosomal snRNP assembly (GO:0000387)3.01117831
92stress fiber assembly (GO:0043149)3.00095381
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99707822
94mannose metabolic process (GO:0006013)2.99278277
957-methylguanosine mRNA capping (GO:0006370)2.99264457
96regulation of cellular amino acid metabolic process (GO:0006521)2.97614290
97pseudouridine synthesis (GO:0001522)2.96525170
98glucose catabolic process (GO:0006007)2.94177865
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94108409
100transcription from RNA polymerase I promoter (GO:0006360)2.93478814
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.91763011
102RNA capping (GO:0036260)2.90400514
1037-methylguanosine RNA capping (GO:0009452)2.90400514
104deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89569980
105negative regulation of cell size (GO:0045792)2.89569111
106rRNA modification (GO:0000154)2.89492718
107activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.89473724
108semaphorin-plexin signaling pathway (GO:0071526)2.88498773
109positive regulation of ligase activity (GO:0051351)2.87508839
110regulation of double-strand break repair via homologous recombination (GO:0010569)2.87476018
111adhesion of symbiont to host (GO:0044406)2.86523957
112termination of RNA polymerase I transcription (GO:0006363)2.85009362
113regulation of apoptotic process involved in morphogenesis (GO:1902337)2.84859482
114virion assembly (GO:0019068)2.84544395
115adhesion of symbiont to host cell (GO:0044650)2.84382268
116virion attachment to host cell (GO:0019062)2.84382268
117attachment of spindle microtubules to kinetochore (GO:0008608)2.83931652
118positive regulation of Cdc42 GTPase activity (GO:0043089)2.83498737
119positive regulation of cell cycle arrest (GO:0071158)2.83406797
120protein localization to chromosome, centromeric region (GO:0071459)2.81155607
121positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.80279632
122endothelial cell chemotaxis (GO:0035767)2.78758391
123peptidyl-proline hydroxylation (GO:0019511)2.77885859
124transcription elongation from RNA polymerase I promoter (GO:0006362)2.76649901
125positive regulation of nuclease activity (GO:0032075)2.75865573
126nucleobase-containing small molecule interconversion (GO:0015949)2.75862789
127cellular component biogenesis (GO:0044085)2.75809731
128metaphase plate congression (GO:0051310)2.73532875
129spliceosomal complex assembly (GO:0000245)2.73112956
130amino sugar catabolic process (GO:0046348)2.72996003
131activation of MAPKKK activity (GO:0000185)2.72535116
132protein complex disassembly (GO:0043241)2.72371689
133hyaluronan catabolic process (GO:0030214)2.71806040
134NADPH regeneration (GO:0006740)2.71663584
135DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.71606286
136NIK/NF-kappaB signaling (GO:0038061)2.71039117
137regulation of ubiquitin-protein transferase activity (GO:0051438)2.70052725
138embryo implantation (GO:0007566)2.69369554
139apoptotic process involved in morphogenesis (GO:0060561)2.67949055
140cellular copper ion homeostasis (GO:0006878)2.67603099
141adherens junction assembly (GO:0034333)2.66238312
142proline biosynthetic process (GO:0006561)2.64674800
143establishment of integrated proviral latency (GO:0075713)2.64532640
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.63033699
145pinocytosis (GO:0006907)2.62901234
146nuclear-transcribed mRNA catabolic process (GO:0000956)2.62404952
147dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62245946
148regulation of translation in response to stress (GO:0043555)2.62107256
149antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.62072036
150regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.61907313
151regulation of ligase activity (GO:0051340)2.61093923
152regulation of superoxide anion generation (GO:0032928)2.60994922
153macromolecular complex disassembly (GO:0032984)2.60654699
154positive regulation of viral transcription (GO:0050434)2.60115927
155diaphragm development (GO:0060539)2.60088565
156cell adhesion mediated by integrin (GO:0033627)2.59248711
157regulation of extracellular matrix disassembly (GO:0010715)2.58974792
158modulation by virus of host process (GO:0019054)2.58031874
159viral protein processing (GO:0019082)2.56314195
160protein hydroxylation (GO:0018126)2.54813364
161ceramide catabolic process (GO:0046514)2.54712597
162endoplasmic reticulum unfolded protein response (GO:0030968)2.53634522
163positive regulation of protein dephosphorylation (GO:0035307)2.53206356
164negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.49896511
165regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.49846733
166epithelial cell-cell adhesion (GO:0090136)2.47749920
167modulation by virus of host morphology or physiology (GO:0019048)2.47633805
168negative regulation of ERBB signaling pathway (GO:1901185)2.46715710
169glial cell migration (GO:0008347)2.46679650
170cellular response to virus (GO:0098586)2.44883939
171regulation of nuclease activity (GO:0032069)2.43696130
172skeletal muscle organ development (GO:0060538)2.42769499
173apoptotic cell clearance (GO:0043277)2.41789384
174negative regulation of erythrocyte differentiation (GO:0045647)2.40514226
175focal adhesion assembly (GO:0048041)2.40480072
176cell-substrate adherens junction assembly (GO:0007045)2.40480072
177response to thyroid hormone (GO:0097066)2.40354287
178cell-cell junction maintenance (GO:0045217)2.40047967
179maternal placenta development (GO:0001893)2.39636095
180oligosaccharide catabolic process (GO:0009313)2.38856228
181planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38303014
182ER-nucleus signaling pathway (GO:0006984)2.37396509
183endocytic recycling (GO:0032456)2.37373378
184regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.37023289
185positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.36475220
186cortical actin cytoskeleton organization (GO:0030866)2.36157399
187negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)2.34992095
188positive regulation of extracellular matrix organization (GO:1903055)2.34808056
189positive regulation of blood vessel endothelial cell migration (GO:0043536)2.34123395
190lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33563672
191low-density lipoprotein particle clearance (GO:0034383)2.33530736
192cellular response to arsenic-containing substance (GO:0071243)2.32948834
193membrane lipid catabolic process (GO:0046466)2.31518608
194positive regulation of receptor recycling (GO:0001921)2.31225846
195maintenance of protein localization in organelle (GO:0072595)2.30681490
196cellular response to unfolded protein (GO:0034620)2.30530602
197response to peptidoglycan (GO:0032494)2.30193260
198spliceosomal tri-snRNP complex assembly (GO:0000244)2.29969138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.17806196
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.84243692
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75501025
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26153857
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.09947163
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05824797
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.96540677
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.91301830
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.83869926
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82201320
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70297645
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69431156
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.58362771
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56106267
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56061489
16LXR_22292898_ChIP-Seq_THP-1_Human2.55239928
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.52870335
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.45886913
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44826199
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.41740995
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39440661
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32494716
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25199733
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23763524
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21098599
26VDR_23849224_ChIP-Seq_CD4+_Human2.20085235
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19065339
28XRN2_22483619_ChIP-Seq_HELA_Human2.16140190
29ZNF263_19887448_ChIP-Seq_K562_Human2.09972839
30RACK7_27058665_Chip-Seq_MCF-7_Human2.09913997
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08806954
32DCP1A_22483619_ChIP-Seq_HELA_Human2.03647176
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02484286
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00146007
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96616010
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95238217
37GABP_19822575_ChIP-Seq_HepG2_Human1.91831649
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85999462
39FOXP3_21729870_ChIP-Seq_TREG_Human1.82756271
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81937372
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78928075
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78317592
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77884859
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77032484
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71258960
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.69363770
47TTF2_22483619_ChIP-Seq_HELA_Human1.69300403
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.65720570
49ELK1_19687146_ChIP-ChIP_HELA_Human1.64677937
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63771085
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.63436615
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61244745
53CLOCK_20551151_ChIP-Seq_293T_Human1.60727202
54TFEB_21752829_ChIP-Seq_HELA_Human1.60515094
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60271495
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60055572
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.57859648
58KDM2B_26808549_Chip-Seq_DND41_Human1.57189322
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55295891
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54267112
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53509004
62AR_21909140_ChIP-Seq_LNCAP_Human1.52797078
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49742738
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49237719
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48861592
66KDM2B_26808549_Chip-Seq_K562_Human1.48489848
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48447216
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.47449579
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47040832
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46546735
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46253516
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44834019
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44834019
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44834019
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42988427
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.41716801
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.41557976
78P68_20966046_ChIP-Seq_HELA_Human1.40828373
79MYC_22102868_ChIP-Seq_BL_Human1.40759627
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39896079
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39830204
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.39789117
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39500213
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39186144
85ATF3_27146783_Chip-Seq_COLON_Human1.38256736
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37961618
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37895169
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37670996
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37394385
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37078738
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36386695
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32940872
93TCF7_22412390_ChIP-Seq_EML_Mouse1.32096493
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31212811
95SPI1_23547873_ChIP-Seq_NB4_Human1.29827100
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.29104951
97KDM5A_27292631_Chip-Seq_BREAST_Human1.28763645
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.28575659
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28189336
100ELK1_22589737_ChIP-Seq_MCF10A_Human1.27300850
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26647418
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26497018
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26216717
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26089139
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25040087
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.24452996
107ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24367622
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24253501
109CIITA_25753668_ChIP-Seq_RAJI_Human1.22920964
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22162201
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20946683
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20424818
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20021586
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19562687
115NCOR1_26117541_ChIP-Seq_K562_Human1.17917104
116TP53_22127205_ChIP-Seq_IMR90_Human1.17624719
117IRF8_21731497_ChIP-ChIP_J774_Mouse1.17499739
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16575770
119CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15976868
120SMC4_20622854_ChIP-Seq_HELA_Human1.15516195
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14226438
122YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13657557
123HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13622015
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12943371
125VDR_24763502_ChIP-Seq_THP-1_Human1.12769973
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11513315
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11092255
128VDR_21846776_ChIP-Seq_THP-1_Human1.10996604
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10719078
130KDM2B_26808549_Chip-Seq_JURKAT_Human1.09753743
131DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09155237
132TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09044201
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08816725
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08319812
135NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06947680
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06309179
137CREB1_26743006_Chip-Seq_LNCaP_Human1.05956213
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05920010
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05287799
140MAF_26560356_Chip-Seq_TH2_Human1.05284215
141SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05035237
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04587792
143CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03882774
144OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03537986
145STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03388694
146BCL6_27268052_Chip-Seq_Bcells_Human1.02953430
147GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02490172
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02473852
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02434434
150BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01261684
151ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01129812
152BCOR_27268052_Chip-Seq_Bcells_Human1.00547685
153NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00341159
154MAF_26560356_Chip-Seq_TH1_Human0.99234320
155SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98986538
156NOTCH1_21737748_ChIP-Seq_TLL_Human0.98743448
157ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98324951
158MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97864634
159NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97817888
160TP63_19390658_ChIP-ChIP_HaCaT_Human0.95234379
161ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95210520
162IRF8_22096565_ChIP-ChIP_GC-B_Human0.91578988
163MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91016008
164SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90190404
165KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88686433
166DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88449811
167IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87501160
168KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87442694
169GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85765041
170CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85570395
171NANOG_21062744_ChIP-ChIP_HESCs_Human0.81870360
172TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80439543

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.30229545
2MP0003705_abnormal_hypodermis_morpholog4.14418107
3MP0004957_abnormal_blastocyst_morpholog3.99219538
4MP0008057_abnormal_DNA_replication3.46781758
5MP0003111_abnormal_nucleus_morphology3.22407805
6MP0003077_abnormal_cell_cycle3.18013827
7MP0010094_abnormal_chromosome_stability3.16544723
8MP0004858_abnormal_nervous_system2.79415295
9MP0005257_abnormal_intraocular_pressure2.56501465
10MP0004510_myositis2.46400579
11MP0008932_abnormal_embryonic_tissue2.41327066
12MP0008058_abnormal_DNA_repair2.35947823
13MP0008007_abnormal_cellular_replicative2.33040695
14MP0005623_abnormal_meninges_morphology2.32467591
15MP0002396_abnormal_hematopoietic_system2.21557338
16MP0003191_abnormal_cellular_cholesterol2.20506757
17MP0004233_abnormal_muscle_weight2.11081658
18MP0009333_abnormal_splenocyte_physiolog2.05089456
19MP0003303_peritoneal_inflammation2.04372088
20MP0010352_gastrointestinal_tract_polyps2.01660850
21MP0003453_abnormal_keratinocyte_physiol1.91156060
22MP0001849_ear_inflammation1.88031200
23MP0003123_paternal_imprinting1.87140003
24MP0000350_abnormal_cell_proliferation1.86866216
25MP0000490_abnormal_crypts_of1.82517116
26MP0003279_aneurysm1.82276080
27MP0001730_embryonic_growth_arrest1.81478696
28MP0003718_maternal_effect1.76071766
29MP0004272_abnormal_basement_membrane1.75687645
30MP0003329_amyloid_beta_deposits1.74964388
31MP0003786_premature_aging1.74396562
32MP0003091_abnormal_cell_migration1.73060574
33MP0005076_abnormal_cell_differentiation1.71345984
34MP0003186_abnormal_redox_activity1.67392865
35MP0005058_abnormal_lysosome_morphology1.65365144
36MP0003436_decreased_susceptibility_to1.62149705
37MP0000751_myopathy1.58633051
38MP0001835_abnormal_antigen_presentation1.55001734
39MP0003806_abnormal_nucleotide_metabolis1.51911778
40MP0004185_abnormal_adipocyte_glucose1.47707954
41MP0003941_abnormal_skin_development1.45529301
42MP0000604_amyloidosis1.44896890
43MP0000733_abnormal_muscle_development1.44788098
44MP0010307_abnormal_tumor_latency1.43772940
45MP0000858_altered_metastatic_potential1.42899783
46MP0003221_abnormal_cardiomyocyte_apopto1.42401668
47MP0005380_embryogenesis_phenotype1.39848681
48MP0001672_abnormal_embryogenesis/_devel1.39848681
49MP0000747_muscle_weakness1.39656192
50MP0005023_abnormal_wound_healing1.39602801
51MP0001697_abnormal_embryo_size1.37999761
52MP0003567_abnormal_fetal_cardiomyocyte1.37312741
53MP0003300_gastrointestinal_ulcer1.37116010
54MP0000678_abnormal_parathyroid_gland1.34186315
55MP0003984_embryonic_growth_retardation1.33935173
56MP0002019_abnormal_tumor_incidence1.33667542
57MP0000313_abnormal_cell_death1.33369596
58MP0003075_altered_response_to1.32731231
59MP0000003_abnormal_adipose_tissue1.31682276
60MP0002132_abnormal_respiratory_system1.31189483
61MP0002088_abnormal_embryonic_growth/wei1.30823458
62MP0009278_abnormal_bone_marrow1.30340220
63MP0002877_abnormal_melanocyte_morpholog1.29936108
64MP0006082_CNS_inflammation1.26969191
65MP0005671_abnormal_response_to1.26754681
66MP0002405_respiratory_system_inflammati1.25312066
67MP0000689_abnormal_spleen_morphology1.24991628
68MP0002080_prenatal_lethality1.24793001
69MP0000685_abnormal_immune_system1.22871905
70MP0002722_abnormal_immune_system1.22393487
71MP0003448_altered_tumor_morphology1.21850077
72MP0002398_abnormal_bone_marrow1.19932418
73MP0001958_emphysema1.18636517
74MP0002060_abnormal_skin_morphology1.17073998
75MP0000759_abnormal_skeletal_muscle1.16869501
76MP0005375_adipose_tissue_phenotype1.14593221
77MP0003763_abnormal_thymus_physiology1.14215148
78MP0003634_abnormal_glial_cell1.13690932
79MP0002086_abnormal_extraembryonic_tissu1.13118427
80MP0001348_abnormal_lacrimal_gland1.11320879
81MP0000767_abnormal_smooth_muscle1.10985788
82MP0002452_abnormal_antigen_presenting1.09492563
83MP0009785_altered_susceptibility_to1.08573468
84MP0005000_abnormal_immune_tolerance1.07918937
85MP0002085_abnormal_embryonic_tissue1.07238033
86MP0000358_abnormal_cell_content/1.06817427
87MP0004808_abnormal_hematopoietic_stem1.05451656
88MP0008438_abnormal_cutaneous_collagen1.04936325
89MP0002429_abnormal_blood_cell1.04847115
90MP0002420_abnormal_adaptive_immunity1.04591013
91MP0002998_abnormal_bone_remodeling1.03365741
92MP0005075_abnormal_melanosome_morpholog1.03188625
93MP0001819_abnormal_immune_cell1.02992817
94MP0003315_abnormal_perineum_morphology1.02407979
95MP0003172_abnormal_lysosome_physiology1.01491086
96MP0005501_abnormal_skin_physiology1.00871877
97MP0005025_abnormal_response_to1.00809124
98MP0001800_abnormal_humoral_immune1.00499019
99MP0005666_abnormal_adipose_tissue1.00464573
100MP0002896_abnormal_bone_mineralization1.00420866
101MP0000716_abnormal_immune_system1.00416799
102MP0002084_abnormal_developmental_patter1.00357154
103MP0003566_abnormal_cell_adhesion1.00174171
104MP0000703_abnormal_thymus_morphology0.99724148
105MP0001243_abnormal_dermal_layer0.98774544
106MP0002723_abnormal_immune_serum0.98614712
107MP0004197_abnormal_fetal_growth/weight/0.97930388
108MP0008260_abnormal_autophagy0.97900270
109MP0005397_hematopoietic_system_phenotyp0.96401377
110MP0001545_abnormal_hematopoietic_system0.96401377
111MP0004947_skin_inflammation0.95240599
112MP0000750_abnormal_muscle_regeneration0.93301825
113MP0002419_abnormal_innate_immunity0.93252627
114MP0005508_abnormal_skeleton_morphology0.91785227
115MP0001542_abnormal_bone_strength0.90478737
116MP0009053_abnormal_anal_canal0.89201790
117MP0002148_abnormal_hypersensitivity_rea0.87887423
118MP0000681_abnormal_thyroid_gland0.86153134
119MP0005390_skeleton_phenotype0.85351754
120MP0005083_abnormal_biliary_tract0.85169031
121MP0003136_yellow_coat_color0.84737892
122MP0001853_heart_inflammation0.84573377
123MP0005330_cardiomyopathy0.83266882
124MP0009840_abnormal_foam_cell0.82706887
125MP0001727_abnormal_embryo_implantation0.81665676
126MP0000749_muscle_degeneration0.81449839
127MP0003011_delayed_dark_adaptation0.81287889
128MP0001790_abnormal_immune_system0.80848324
129MP0005387_immune_system_phenotype0.80848324
130MP0005165_increased_susceptibility_to0.80185569
131MP0005384_cellular_phenotype0.79434242
132MP0002249_abnormal_larynx_morphology0.78303361
133MP0001915_intracranial_hemorrhage0.76787673
134MP0003950_abnormal_plasma_membrane0.76278177
135MP0004087_abnormal_muscle_fiber0.76258050
136MP0005621_abnormal_cell_physiology0.75965374
137MP0008877_abnormal_DNA_methylation0.75749212
138MP0001533_abnormal_skeleton_physiology0.73812111
139MP0010030_abnormal_orbit_morphology0.73187419
140MP0008874_decreased_physiological_sensi0.72036636
141MP0004264_abnormal_extraembryonic_tissu0.71962653
142MP0001293_anophthalmia0.71097868
143MP0000465_gastrointestinal_hemorrhage0.70105194
144MP0006054_spinal_hemorrhage0.69888477
145MP0005451_abnormal_body_composition0.69505353
146MP0002089_abnormal_postnatal_growth/wei0.69505119
147MP0005670_abnormal_white_adipose0.69466755
148MP0000343_altered_response_to0.69311376
149MP0002933_joint_inflammation0.69102250
150MP0002332_abnormal_exercise_endurance0.68732164
151MP0002139_abnormal_hepatobiliary_system0.68122976
152MP0003879_abnormal_hair_cell0.68063969
153MP0002269_muscular_atrophy0.67426778
154MP0001216_abnormal_epidermal_layer0.66365967
155MP0008004_abnormal_stomach_pH0.66314780
156MP0003795_abnormal_bone_structure0.66281050
157MP0000428_abnormal_craniofacial_morphol0.66019505
158MP0005503_abnormal_tendon_morphology0.65871278
159MP0000537_abnormal_urethra_morphology0.64337501
160MP0005464_abnormal_platelet_physiology0.64320554
161MP0010234_abnormal_vibrissa_follicle0.64282055
162MP0002113_abnormal_skeleton_development0.64100197
163MP0000477_abnormal_intestine_morphology0.63810212
164MP0003942_abnormal_urinary_system0.63794971
165MP0002796_impaired_skin_barrier0.63674207
166MP0002295_abnormal_pulmonary_circulatio0.62370627

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.67650634
2Abnormality of cells of the erythroid lineage (HP:0012130)4.10944763
3Multiple enchondromatosis (HP:0005701)4.01529097
4Abnormal number of erythroid precursors (HP:0012131)3.75722851
5Breast hypoplasia (HP:0003187)3.68952865
6Protrusio acetabuli (HP:0003179)3.65793635
7Achilles tendon contracture (HP:0001771)3.48321213
8Nuclear cataract (HP:0100018)3.45641380
9Reticulocytopenia (HP:0001896)3.45325999
10Cerebral hypomyelination (HP:0006808)3.39210385
11Rough bone trabeculation (HP:0100670)3.33360163
12Hyperacusis (HP:0010780)3.24677934
13Axonal loss (HP:0003447)3.16306767
14Trismus (HP:0000211)3.16101818
15Carpal bone hypoplasia (HP:0001498)3.14513308
16Distal upper limb amyotrophy (HP:0007149)3.11254923
17Upper limb amyotrophy (HP:0009129)3.11254923
18Abnormality of the Achilles tendon (HP:0005109)3.06867048
19Distal lower limb amyotrophy (HP:0008944)3.01716157
20Dysostosis multiplex (HP:0000943)2.98952614
21Degeneration of anterior horn cells (HP:0002398)2.98352583
22Abnormality of the anterior horn cell (HP:0006802)2.98352583
23Cholecystitis (HP:0001082)2.92823959
24Abnormal gallbladder physiology (HP:0012438)2.92823959
25Macrocytic anemia (HP:0001972)2.88487341
26Agnosia (HP:0010524)2.84234732
27Increased connective tissue (HP:0009025)2.82148955
28Abnormality of the umbilical cord (HP:0010881)2.81454744
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.77163403
30Patellar aplasia (HP:0006443)2.67583976
31Distal lower limb muscle weakness (HP:0009053)2.64692114
32Selective tooth agenesis (HP:0001592)2.60205171
33Neurofibrillary tangles (HP:0002185)2.60074635
34Aplasia/Hypoplasia of the patella (HP:0006498)2.57845490
35Short nail (HP:0001799)2.57480004
36Hand muscle atrophy (HP:0009130)2.56051187
37Microretrognathia (HP:0000308)2.54834861
38Spinal rigidity (HP:0003306)2.53934688
39Cerebral aneurysm (HP:0004944)2.53872943
40Cervical subluxation (HP:0003308)2.49660853
41Recurrent abscess formation (HP:0002722)2.49650331
42Pallor (HP:0000980)2.48576303
43Vertebral compression fractures (HP:0002953)2.47002563
44Loss of speech (HP:0002371)2.46018163
45Premature graying of hair (HP:0002216)2.42415543
46Abnormal trabecular bone morphology (HP:0100671)2.42236542
47Thrombocytosis (HP:0001894)2.40475871
48J-shaped sella turcica (HP:0002680)2.39816052
49Cerebral inclusion bodies (HP:0100314)2.38646898
50Petechiae (HP:0000967)2.38311894
51Insomnia (HP:0100785)2.36374192
52Ulnar bowing (HP:0003031)2.35957576
53Supranuclear gaze palsy (HP:0000605)2.34842489
54Exertional dyspnea (HP:0002875)2.34330003
55Muscle fiber atrophy (HP:0100295)2.33811770
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31685418
57Oral leukoplakia (HP:0002745)2.29943334
58Aplastic anemia (HP:0001915)2.29499397
59Type I transferrin isoform profile (HP:0003642)2.27964798
60Ankle contracture (HP:0006466)2.27555401
61Personality changes (HP:0000751)2.27351883
62Fragile skin (HP:0001030)2.25973261
63Abnormality of the fetal cardiovascular system (HP:0010948)2.25389259
64Abnormal umbilical cord blood vessels (HP:0011403)2.25389259
65Single umbilical artery (HP:0001195)2.25389259
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24916415
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24916415
68Abnormality of polysaccharide metabolism (HP:0011012)2.24916415
69Abnormality of liposaccharide metabolism (HP:0010968)2.24734305
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.24734305
71Abnormality of glycolipid metabolism (HP:0010969)2.24734305
72Glossoptosis (HP:0000162)2.22620831
73Ependymoma (HP:0002888)2.22126979
74Hyperparathyroidism (HP:0000843)2.21172255
75Prolonged neonatal jaundice (HP:0006579)2.20594876
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.18097824
77Mitral regurgitation (HP:0001653)2.17930531
78Upper motor neuron abnormality (HP:0002127)2.17365905
79Apathy (HP:0000741)2.16908150
80Broad distal phalanx of finger (HP:0009836)2.16433838
81Absent radius (HP:0003974)2.16291108
82Impulsivity (HP:0100710)2.16191543
83Mucopolysacchariduria (HP:0008155)2.13984947
84Urinary glycosaminoglycan excretion (HP:0003541)2.13984947
85Centrally nucleated skeletal muscle fibers (HP:0003687)2.13673699
86Lower limb amyotrophy (HP:0007210)2.12904068
87Secondary amenorrhea (HP:0000869)2.12126725
88Atrophic scars (HP:0001075)2.11952640
89Systemic lupus erythematosus (HP:0002725)2.10187090
90Diminished motivation (HP:0000745)2.10134602
91Bladder diverticulum (HP:0000015)2.09400222
92Pustule (HP:0200039)2.08668008
93Blue sclerae (HP:0000592)2.07750211
94Premature ovarian failure (HP:0008209)2.07621773
95Elbow flexion contracture (HP:0002987)2.07460287
96Poor head control (HP:0002421)2.07192038
97Nonimmune hydrops fetalis (HP:0001790)2.05321937
98Aplasia involving forearm bones (HP:0009822)2.05182274
99Absent forearm bone (HP:0003953)2.05182274
100Long palpebral fissure (HP:0000637)2.05126704
101Abnormal hemoglobin (HP:0011902)2.04334781
102Difficulty climbing stairs (HP:0003551)2.03730846
103Broad face (HP:0000283)2.03364971
104Abnormalities of placenta or umbilical cord (HP:0001194)2.02960953
105Thin bony cortex (HP:0002753)2.02861572
106Generalized amyotrophy (HP:0003700)2.02374798
107Hypertensive crisis (HP:0100735)2.02352544
108Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.02219237
109Genu recurvatum (HP:0002816)2.01068799
110IgM deficiency (HP:0002850)2.00900864
111Abnormality of dentin (HP:0010299)1.99846589
112Aplasia/hypoplasia of the humerus (HP:0006507)1.98004419
113Ragged-red muscle fibers (HP:0003200)1.97816620
114Biconcave vertebral bodies (HP:0004586)1.97550684
115Mildly elevated creatine phosphokinase (HP:0008180)1.96089046
116Type 2 muscle fiber atrophy (HP:0003554)1.95353267
117Wormian bones (HP:0002645)1.93997773
118Increased cerebral lipofuscin (HP:0011813)1.93828352
119Neoplasm of the pancreas (HP:0002894)1.91958264
120Premature rupture of membranes (HP:0001788)1.90736873
121Myopathic facies (HP:0002058)1.90198274
122Disproportionate tall stature (HP:0001519)1.90093214
123Progressive neurologic deterioration (HP:0002344)1.89912428
124Recurrent bacterial skin infections (HP:0005406)1.89817035
125Neuronal loss in central nervous system (HP:0002529)1.89421458
126Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89128642
127Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89128642
128Myocardial infarction (HP:0001658)1.88604927
129Bone marrow hypocellularity (HP:0005528)1.87246695
130Abnormality of glycolysis (HP:0004366)1.86852413
131Increased serum pyruvate (HP:0003542)1.86852413
132Ureteral duplication (HP:0000073)1.86549135
133Fused cervical vertebrae (HP:0002949)1.86022784
134Abnormality of macrophages (HP:0004311)1.85735191
135Stridor (HP:0010307)1.85180175
136Colon cancer (HP:0003003)1.84743890
137Nausea (HP:0002018)1.83971700
138Aplasia/Hypoplasia involving the musculature (HP:0001460)1.83577513
139Vacuolated lymphocytes (HP:0001922)1.82989752
140Joint stiffness (HP:0001387)1.80772731
141Rhabdomyosarcoma (HP:0002859)1.80639795
142Increased variability in muscle fiber diameter (HP:0003557)1.79939651
143Abnormality of the distal phalanges of the toes (HP:0010182)1.79855933
144Abnormality of the tricuspid valve (HP:0001702)1.79820377
145Interstitial pulmonary disease (HP:0006530)1.79720453
146Hepatocellular necrosis (HP:0001404)1.79594304
147Eczematoid dermatitis (HP:0000976)1.79466143
148Calcaneovalgus deformity (HP:0001848)1.78067335
149Increased hepatocellular lipid droplets (HP:0006565)1.75318033
150Bone pain (HP:0002653)1.75267505
151Purpura (HP:0000979)1.74102234
152Sparse lateral eyebrow (HP:0005338)1.74094770
153Abnormality of skeletal muscle fiber size (HP:0012084)1.74078663
154Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74054534
155Slender long bone (HP:0003100)1.73862016
156Atrophy/Degeneration involving motor neurons (HP:0007373)1.73138905
157Atelectasis (HP:0100750)1.73025142
158Tongue fasciculations (HP:0001308)1.72921702
159Amyloidosis (HP:0011034)1.72630178
160Patellar dislocation (HP:0002999)1.72543061
161Absent thumb (HP:0009777)1.71862109
162Hepatic necrosis (HP:0002605)1.71705562
163Granulocytopenia (HP:0001913)1.71692176
164Abnormality of T cell physiology (HP:0011840)1.71361743
165Osteolytic defects of the hand bones (HP:0009699)1.71251163
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.71251163
167Spastic paraparesis (HP:0002313)1.70815303
168Lymphoma (HP:0002665)1.70713226
169Long toe (HP:0010511)1.70696979
170Abnormality of lateral ventricle (HP:0030047)1.70075320
171Hyperthyroidism (HP:0000836)1.69896478
172Deformed tarsal bones (HP:0008119)1.69695153
173Congenital ichthyosiform erythroderma (HP:0007431)1.69557923
174Bulbar palsy (HP:0001283)1.68838419
175Reduced subcutaneous adipose tissue (HP:0003758)1.68826959
176Myelodysplasia (HP:0002863)1.68022871
177Reduced antithrombin III activity (HP:0001976)1.67929626
178Abnormal cartilage morphology (HP:0002763)1.67351468
179Back pain (HP:0003418)1.67162807
180Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.67032436
181Meckel diverticulum (HP:0002245)1.66819814
182Pathologic fracture (HP:0002756)1.66040966
183Sparse eyelashes (HP:0000653)1.65896006
184Short clavicles (HP:0000894)1.65868047
185Increased serum lactate (HP:0002151)1.65493582
186Renal duplication (HP:0000075)1.63992462
187Hypokinesia (HP:0002375)1.63507139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.79251654
2TRIB33.74002024
3NME23.63098497
4WEE13.59760229
5CDC72.82752748
6EIF2AK12.43612886
7TESK22.41331218
8PIM22.38392946
9ICK2.31925469
10SIK12.16425420
11EIF2AK32.03593287
12PRPF4B2.02383983
13TAOK21.98400968
14SMG11.92874610
15STK161.89589856
16ACVR1B1.81202169
17BRSK21.77314399
18PLK11.75579125
19TTK1.75026616
20TTN1.72358229
21NEK21.68612198
22PLK41.68247376
23TSSK61.68166098
24PBK1.63151586
25BLK1.61389885
26STK101.57468028
27RPS6KA41.57147325
28CDK71.56825105
29MAP4K11.55164328
30EPHA21.54928483
31RIPK11.47623376
32KDR1.44923956
33MOS1.44037835
34PAK41.38490501
35VRK11.32556617
36AURKB1.31960927
37PTK21.31779646
38ZAP701.29184199
39NTRK11.28407920
40PKN21.27071887
41TAOK11.25870831
42CHEK21.23015643
43DYRK31.21730843
44SRPK11.20599535
45NEK11.15247574
46EEF2K1.13702581
47AURKA1.13690573
48PIM11.13116944
49EPHB21.10877958
50LMTK21.06383184
51MST1R1.04828749
52MST41.03695756
53LRRK21.03456599
54KIT1.02370620
55IRAK41.01320236
56CDK80.97009829
57IRAK30.96611324
58ZAK0.95593705
59ATR0.93841128
60STK40.92126127
61RPS6KB20.91816483
62CSF1R0.91606175
63CDK40.91521778
64CDC42BPA0.91507153
65IKBKB0.91267182
66MAP3K80.90238864
67RPS6KA20.89182914
68NME10.89139476
69BCKDK0.88722172
70ILK0.88586385
71SIK30.88490121
72MAP3K10.88263522
73ABL20.87952852
74TYK20.87672460
75PAK10.87545270
76KSR20.86239999
77MAP3K110.85058228
78EPHB10.84697398
79SCYL20.84344638
80GRK60.83173461
81CHEK10.81546429
82PRKD30.80603489
83PRKD20.79811416
84IRAK20.79698272
85BRSK10.78002624
86BMX0.77991124
87MTOR0.75926948
88CSNK2A10.74656537
89SIK20.72004049
90PLK30.71047575
91CDK120.70966289
92PASK0.70881251
93MKNK10.70874206
94DMPK0.69812471
95DAPK30.69598108
96ERN10.69583775
97DYRK20.68727125
98FGFR40.68658184
99CSNK2A20.67843264
100LIMK10.67577139
101CDK11A0.66837256
102MAP2K30.66547517
103TXK0.65684981
104PTK60.65586736
105TESK10.65359405
106PDPK10.64375814
107MAP3K30.64286344
108MAP3K130.62546172
109CDK150.62090172
110TBK10.61961713
111BRAF0.61831137
112MAPKAPK30.61299892
113TGFBR20.60991810
114CDK140.59598210
115CDK20.59548984
116TGFBR10.59124464
117RPS6KA50.58292448
118MATK0.57377283
119TLK10.57354178
120CDK180.56705882
121ARAF0.56577785
122CLK10.55087285
123LYN0.54154114
124RPS6KC10.53960820
125RPS6KL10.53960820
126PAK60.53809179
127MET0.53660163
128MAP3K140.53354893
129MAP3K100.53161840
130FLT30.53145358
131CAMK2G0.53003221
132MAP2K20.52036009
133LATS20.51675044
134MARK20.51442305
135TYRO30.51098950
136MAP3K90.50783058
137PAK20.49618946
138CSK0.47755669
139CSNK1G30.47014261
140VRK20.46844419
141MELK0.46753547
142MAP3K120.46299718
143LCK0.45872923
144PRKG20.45219815
145AKT30.45095878
146BTK0.43435433
147DDR20.42674053
148MYLK0.42550861
149CDK90.41742281
150AKT20.40966285
151PRKCI0.39653096
152MAP3K60.39279081
153FGR0.38034048
154DAPK10.37380985
155MAPKAPK20.37089446
156STK240.36664281
157JAK30.36422045
158TEC0.36285130
159PDGFRA0.36212148
160KSR10.35802826
161DYRK1B0.34245277
162ROCK20.32506842

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.20019574
2Proteasome_Homo sapiens_hsa030504.10177315
3Ribosome_Homo sapiens_hsa030103.89419542
4Mismatch repair_Homo sapiens_hsa034303.65406150
5RNA polymerase_Homo sapiens_hsa030203.36230341
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11454360
7Spliceosome_Homo sapiens_hsa030402.83408004
8Base excision repair_Homo sapiens_hsa034102.82846743
9Homologous recombination_Homo sapiens_hsa034402.62101313
10Nucleotide excision repair_Homo sapiens_hsa034202.51684331
11RNA transport_Homo sapiens_hsa030132.44111706
12Pyrimidine metabolism_Homo sapiens_hsa002402.27507075
13Vibrio cholerae infection_Homo sapiens_hsa051102.22448179
14Prion diseases_Homo sapiens_hsa050202.15630735
15Cell cycle_Homo sapiens_hsa041102.07612471
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76509403
17Salmonella infection_Homo sapiens_hsa051321.74305467
18Protein export_Homo sapiens_hsa030601.72626437
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.67611550
20Basal transcription factors_Homo sapiens_hsa030221.66480866
21Chronic myeloid leukemia_Homo sapiens_hsa052201.59477858
22One carbon pool by folate_Homo sapiens_hsa006701.55139120
23Folate biosynthesis_Homo sapiens_hsa007901.54057813
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.53654550
25p53 signaling pathway_Homo sapiens_hsa041151.53444444
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48318328
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46880663
28VEGF signaling pathway_Homo sapiens_hsa043701.46528161
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39933055
30RNA degradation_Homo sapiens_hsa030181.39324713
31Fanconi anemia pathway_Homo sapiens_hsa034601.33212954
32Non-homologous end-joining_Homo sapiens_hsa034501.29144996
33Pancreatic cancer_Homo sapiens_hsa052121.28757680
34Acute myeloid leukemia_Homo sapiens_hsa052211.26359531
35Antigen processing and presentation_Homo sapiens_hsa046121.25539832
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22998688
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19557037
38Epstein-Barr virus infection_Homo sapiens_hsa051691.19350938
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19230779
40Osteoclast differentiation_Homo sapiens_hsa043801.17367688
41Pentose phosphate pathway_Homo sapiens_hsa000301.16631139
42Vitamin B6 metabolism_Homo sapiens_hsa007501.11308372
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.11105082
44Purine metabolism_Homo sapiens_hsa002301.10416871
45Oxidative phosphorylation_Homo sapiens_hsa001901.09745888
46Renal cell carcinoma_Homo sapiens_hsa052111.09573923
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09017244
48Synaptic vesicle cycle_Homo sapiens_hsa047211.08899226
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06868429
50Parkinsons disease_Homo sapiens_hsa050121.06496129
51Endocytosis_Homo sapiens_hsa041441.06217769
52Other glycan degradation_Homo sapiens_hsa005111.03959864
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98074147
54TNF signaling pathway_Homo sapiens_hsa046680.96748441
55Non-small cell lung cancer_Homo sapiens_hsa052230.95963452
56Focal adhesion_Homo sapiens_hsa045100.94824355
57Lysosome_Homo sapiens_hsa041420.93890419
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93835339
59Glutathione metabolism_Homo sapiens_hsa004800.93647324
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93331347
61Pertussis_Homo sapiens_hsa051330.92860996
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92715522
63Amoebiasis_Homo sapiens_hsa051460.92413674
64mRNA surveillance pathway_Homo sapiens_hsa030150.91143442
65Thyroid cancer_Homo sapiens_hsa052160.90085535
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89552261
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88210697
68Proteoglycans in cancer_Homo sapiens_hsa052050.86889416
69Huntingtons disease_Homo sapiens_hsa050160.86509058
70Regulation of autophagy_Homo sapiens_hsa041400.85762186
71Primary immunodeficiency_Homo sapiens_hsa053400.83337450
72Insulin signaling pathway_Homo sapiens_hsa049100.81372399
73Glioma_Homo sapiens_hsa052140.80963363
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.80053361
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79327799
76Galactose metabolism_Homo sapiens_hsa000520.78781662
77Herpes simplex infection_Homo sapiens_hsa051680.78559142
78HIF-1 signaling pathway_Homo sapiens_hsa040660.77450401
79Hepatitis C_Homo sapiens_hsa051600.77214748
80Tuberculosis_Homo sapiens_hsa051520.76124212
81Legionellosis_Homo sapiens_hsa051340.75696121
82Collecting duct acid secretion_Homo sapiens_hsa049660.72218271
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72008672
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71873072
85Fructose and mannose metabolism_Homo sapiens_hsa000510.71148026
86Toxoplasmosis_Homo sapiens_hsa051450.70854450
87Endometrial cancer_Homo sapiens_hsa052130.70850217
88ErbB signaling pathway_Homo sapiens_hsa040120.69634370
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68620707
90Rheumatoid arthritis_Homo sapiens_hsa053230.68543554
91B cell receptor signaling pathway_Homo sapiens_hsa046620.66995736
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.66425672
93Apoptosis_Homo sapiens_hsa042100.64956770
94Sulfur relay system_Homo sapiens_hsa041220.64500366
95Biosynthesis of amino acids_Homo sapiens_hsa012300.63961786
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.63708729
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.61796459
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.59889712
99Leishmaniasis_Homo sapiens_hsa051400.59211935
100Shigellosis_Homo sapiens_hsa051310.56782640
101Viral carcinogenesis_Homo sapiens_hsa052030.56160636
102Arachidonic acid metabolism_Homo sapiens_hsa005900.56123809
103Influenza A_Homo sapiens_hsa051640.54670843
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54371163
105mTOR signaling pathway_Homo sapiens_hsa041500.53932533
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53581517
107HTLV-I infection_Homo sapiens_hsa051660.53187886
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51062458
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50617954
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50512735
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50329868
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.50286852
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.49460268
114Estrogen signaling pathway_Homo sapiens_hsa049150.49359268
115AMPK signaling pathway_Homo sapiens_hsa041520.49168636
116Caffeine metabolism_Homo sapiens_hsa002320.49102520
117Measles_Homo sapiens_hsa051620.49016073
118Hematopoietic cell lineage_Homo sapiens_hsa046400.48577359
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48300669
120Graft-versus-host disease_Homo sapiens_hsa053320.47084502
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46971690
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46474496
123Alzheimers disease_Homo sapiens_hsa050100.45275963
124Dilated cardiomyopathy_Homo sapiens_hsa054140.44956993
125Adherens junction_Homo sapiens_hsa045200.44732708
126Prolactin signaling pathway_Homo sapiens_hsa049170.44577863
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44537453
128GnRH signaling pathway_Homo sapiens_hsa049120.44353369
129Malaria_Homo sapiens_hsa051440.43513964
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.43425396
131Phagosome_Homo sapiens_hsa041450.43011967
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41751469
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.41510063
134Carbon metabolism_Homo sapiens_hsa012000.41113489
135Asthma_Homo sapiens_hsa053100.38442676
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38249673
137Metabolic pathways_Homo sapiens_hsa011000.35989207
138MicroRNAs in cancer_Homo sapiens_hsa052060.34408338
139N-Glycan biosynthesis_Homo sapiens_hsa005100.34048543
140Renin-angiotensin system_Homo sapiens_hsa046140.31879809
141Viral myocarditis_Homo sapiens_hsa054160.31014516
142Bladder cancer_Homo sapiens_hsa052190.30265454
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28995507
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28567158
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.28325368
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27980668
147Arginine and proline metabolism_Homo sapiens_hsa003300.27966832
148Allograft rejection_Homo sapiens_hsa053300.27331766
149TGF-beta signaling pathway_Homo sapiens_hsa043500.26377210
150Notch signaling pathway_Homo sapiens_hsa043300.23683975
151Steroid biosynthesis_Homo sapiens_hsa001000.23651477
152RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23487971
153Small cell lung cancer_Homo sapiens_hsa052220.22956016
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22836714
155Hepatitis B_Homo sapiens_hsa051610.21409651
156Oocyte meiosis_Homo sapiens_hsa041140.20728345
157Autoimmune thyroid disease_Homo sapiens_hsa053200.20256192
158Selenocompound metabolism_Homo sapiens_hsa004500.19036047
159Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17713558
160Sphingolipid metabolism_Homo sapiens_hsa006000.17708533

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