FAM47E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.55941386
2L-phenylalanine catabolic process (GO:0006559)7.55941386
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.15607611
4L-phenylalanine metabolic process (GO:0006558)7.15607611
5aromatic amino acid family catabolic process (GO:0009074)6.95795342
6indole-containing compound catabolic process (GO:0042436)6.38502779
7indolalkylamine catabolic process (GO:0046218)6.38502779
8tryptophan catabolic process (GO:0006569)6.38502779
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.02860156
10kynurenine metabolic process (GO:0070189)6.02710660
11tryptophan metabolic process (GO:0006568)6.02193449
12bile acid biosynthetic process (GO:0006699)5.96893383
13cilium or flagellum-dependent cell motility (GO:0001539)5.88129648
14glyoxylate metabolic process (GO:0046487)5.65550861
15urea cycle (GO:0000050)5.62117848
16urea metabolic process (GO:0019627)5.62117848
17high-density lipoprotein particle remodeling (GO:0034375)5.51373289
18negative regulation of fibrinolysis (GO:0051918)5.45526544
19complement activation, alternative pathway (GO:0006957)5.37068520
20regulation of cholesterol esterification (GO:0010872)5.36743622
21regulation of protein activation cascade (GO:2000257)5.35029425
22alpha-linolenic acid metabolic process (GO:0036109)5.33988781
23peptidyl-glutamic acid carboxylation (GO:0017187)5.29756572
24protein carboxylation (GO:0018214)5.29756572
25regulation of fibrinolysis (GO:0051917)5.29484805
26nitrogen cycle metabolic process (GO:0071941)5.14487468
27cysteine metabolic process (GO:0006534)5.13893791
28bile acid metabolic process (GO:0008206)5.10797685
29regulation of complement activation (GO:0030449)5.03616495
30sulfur amino acid catabolic process (GO:0000098)5.02084587
31aromatic amino acid family metabolic process (GO:0009072)5.01001007
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.99068229
33cilium movement (GO:0003341)4.98979226
34serine family amino acid catabolic process (GO:0009071)4.98820769
35regulation of triglyceride catabolic process (GO:0010896)4.84005771
36reverse cholesterol transport (GO:0043691)4.82329873
37axonemal dynein complex assembly (GO:0070286)4.82267128
38tyrosine metabolic process (GO:0006570)4.79186915
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.75703242
40homocysteine metabolic process (GO:0050667)4.72822772
41plasma lipoprotein particle remodeling (GO:0034369)4.67096284
42protein-lipid complex remodeling (GO:0034368)4.67096284
43macromolecular complex remodeling (GO:0034367)4.67096284
44epithelial cilium movement (GO:0003351)4.65966783
45alpha-amino acid catabolic process (GO:1901606)4.65788938
46acylglycerol homeostasis (GO:0055090)4.57408877
47triglyceride homeostasis (GO:0070328)4.57408877
48cellular biogenic amine catabolic process (GO:0042402)4.57230761
49amine catabolic process (GO:0009310)4.57230761
50amino-acid betaine metabolic process (GO:0006577)4.54559997
51indolalkylamine metabolic process (GO:0006586)4.51984851
52cellular ketone body metabolic process (GO:0046950)4.50003041
53coenzyme catabolic process (GO:0009109)4.47853894
54lysine catabolic process (GO:0006554)4.46902695
55lysine metabolic process (GO:0006553)4.46902695
56aldehyde catabolic process (GO:0046185)4.46078406
57phospholipid efflux (GO:0033700)4.44639515
58bile acid and bile salt transport (GO:0015721)4.44236436
59imidazole-containing compound metabolic process (GO:0052803)4.37974892
60negative regulation of cholesterol transport (GO:0032375)4.34829857
61negative regulation of sterol transport (GO:0032372)4.34829857
62axoneme assembly (GO:0035082)4.23107618
63cellular amino acid catabolic process (GO:0009063)4.22795330
64cellular glucuronidation (GO:0052695)4.20118334
65cholesterol efflux (GO:0033344)4.19920660
66drug catabolic process (GO:0042737)4.18736607
67ethanol oxidation (GO:0006069)4.17112758
68benzene-containing compound metabolic process (GO:0042537)4.16431088
69glutamate metabolic process (GO:0006536)4.14269987
70plasma lipoprotein particle clearance (GO:0034381)4.13067104
71glycine metabolic process (GO:0006544)4.12951286
72serine family amino acid metabolic process (GO:0009069)4.03896796
73fibrinolysis (GO:0042730)4.01663954
74arginine metabolic process (GO:0006525)3.99465161
75low-density lipoprotein particle remodeling (GO:0034374)3.93168230
76ketone body metabolic process (GO:1902224)3.88405664
77cellular modified amino acid catabolic process (GO:0042219)3.88113586
78cofactor catabolic process (GO:0051187)3.84739738
79blood coagulation, intrinsic pathway (GO:0007597)3.82613547
80complement activation, classical pathway (GO:0006958)3.81191234
81uronic acid metabolic process (GO:0006063)3.81043066
82glucuronate metabolic process (GO:0019585)3.81043066
83dicarboxylic acid biosynthetic process (GO:0043650)3.80891283
84serine family amino acid biosynthetic process (GO:0009070)3.79605900
85negative regulation of lipase activity (GO:0060192)3.76527350
86cholesterol homeostasis (GO:0042632)3.75657489
87complement activation (GO:0006956)3.75621098
88regulation of bile acid biosynthetic process (GO:0070857)3.72760603
89positive regulation of triglyceride lipase activity (GO:0061365)3.72743005
90positive regulation of lipoprotein lipase activity (GO:0051006)3.72743005
91protein activation cascade (GO:0072376)3.72551619
92exogenous drug catabolic process (GO:0042738)3.71491999
93organic acid catabolic process (GO:0016054)3.70743160
94carboxylic acid catabolic process (GO:0046395)3.70743160
95detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.70528216
96phospholipid homeostasis (GO:0055091)3.70140071
97plasma lipoprotein particle assembly (GO:0034377)3.70080922
98sterol homeostasis (GO:0055092)3.69048039
99NAD biosynthetic process (GO:0009435)3.68740155
100cytolysis (GO:0019835)3.68419169
101behavioral response to nicotine (GO:0035095)3.67621487
102short-chain fatty acid metabolic process (GO:0046459)3.65920257
103opsonization (GO:0008228)3.64826846
104response to nitrosative stress (GO:0051409)3.59620992
105positive regulation of lipid catabolic process (GO:0050996)3.57791889
106pyridine nucleotide biosynthetic process (GO:0019363)3.56495548
107nicotinamide nucleotide biosynthetic process (GO:0019359)3.56495548
108photoreceptor cell maintenance (GO:0045494)3.55966045
109negative regulation of protein activation cascade (GO:2000258)3.53256142
110detection of light stimulus involved in sensory perception (GO:0050962)3.49717342
111detection of light stimulus involved in visual perception (GO:0050908)3.49717342
112fucose catabolic process (GO:0019317)3.48493647
113L-fucose metabolic process (GO:0042354)3.48493647
114L-fucose catabolic process (GO:0042355)3.48493647
115motile cilium assembly (GO:0044458)3.48048094
116signal peptide processing (GO:0006465)3.44078106
117indole-containing compound metabolic process (GO:0042430)3.37246671
118cilium organization (GO:0044782)3.34814371
119sphingoid metabolic process (GO:0046519)3.30711596
120regulation of cilium movement (GO:0003352)3.30049610
121protein localization to cilium (GO:0061512)3.28776691
122cilium assembly (GO:0042384)3.28604577
123negative regulation of cytosolic calcium ion concentration (GO:0051481)3.28055498
124intraciliary transport (GO:0042073)3.21474290
125gamma-aminobutyric acid transport (GO:0015812)3.10295520
126oxidative demethylation (GO:0070989)3.10078987
127cilium morphogenesis (GO:0060271)3.03955961
128auditory receptor cell stereocilium organization (GO:0060088)3.02418919
129water-soluble vitamin biosynthetic process (GO:0042364)2.89129409
130establishment of protein localization to Golgi (GO:0072600)2.84332471
131neural tube formation (GO:0001841)2.82783517
132L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82190912
133amino acid salvage (GO:0043102)2.81615050
134L-methionine salvage (GO:0071267)2.81615050
135L-methionine biosynthetic process (GO:0071265)2.81615050
136piRNA metabolic process (GO:0034587)2.80717055
137retinal cone cell development (GO:0046549)2.77433717
138reflex (GO:0060004)2.76737728
139behavioral response to ethanol (GO:0048149)2.76264487
140xenobiotic catabolic process (GO:0042178)2.74057024
141response to pheromone (GO:0019236)2.71849139
142cellular component assembly involved in morphogenesis (GO:0010927)2.70952631
143primary amino compound metabolic process (GO:1901160)2.70747367
144regulation of memory T cell differentiation (GO:0043380)2.69235540
145dopamine transport (GO:0015872)2.66963106
146left/right axis specification (GO:0070986)2.66171072
147thyroid hormone metabolic process (GO:0042403)2.66130986
148proline transport (GO:0015824)2.64875361
149serotonin metabolic process (GO:0042428)2.64583674
150neuronal action potential propagation (GO:0019227)2.62954757
151inner ear receptor stereocilium organization (GO:0060122)2.62718794
152DNA methylation involved in gamete generation (GO:0043046)2.57904685
153negative regulation of multicellular organism growth (GO:0040015)2.57733315
154protein polyglutamylation (GO:0018095)2.57410344
155flavonoid metabolic process (GO:0009812)2.56295237
156regulation of action potential (GO:0098900)2.55550500
157one-carbon compound transport (GO:0019755)2.54150959
158neuronal action potential (GO:0019228)2.52862388
159sphingosine metabolic process (GO:0006670)2.51499358
160adaptation of signaling pathway (GO:0023058)2.50807877
161regulation of establishment of cell polarity (GO:2000114)2.47593906
162regulation of glucokinase activity (GO:0033131)2.46387543
163regulation of hexokinase activity (GO:1903299)2.46387543
164regulation of hippo signaling (GO:0035330)2.42382153
165nonmotile primary cilium assembly (GO:0035058)2.40503410
166detection of mechanical stimulus involved in sensory perception (GO:0050974)2.38712452
167rRNA catabolic process (GO:0016075)2.38647332
168organic cation transport (GO:0015695)2.37988288
169photoreceptor cell development (GO:0042461)2.37360128
170ADP metabolic process (GO:0046031)2.36754920
171sex differentiation (GO:0007548)2.36743915
172transmission of nerve impulse (GO:0019226)2.36446701
173S-adenosylmethionine metabolic process (GO:0046500)2.36089070
174regulation of acrosome reaction (GO:0060046)2.35335285
175diol metabolic process (GO:0034311)2.33620896
176methionine biosynthetic process (GO:0009086)2.32450876
177tachykinin receptor signaling pathway (GO:0007217)2.32338724
178epoxygenase P450 pathway (GO:0019373)2.32266210
179G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32009952
180multicellular organism reproduction (GO:0032504)2.27679428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.88773272
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.04575595
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.66772611
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.21431439
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.94525902
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.85448502
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.05938398
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.91434673
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.83752403
10GBX2_23144817_ChIP-Seq_PC3_Human3.34905106
11VDR_22108803_ChIP-Seq_LS180_Human3.15930547
12ZNF274_21170338_ChIP-Seq_K562_Hela2.87996151
13IGF1R_20145208_ChIP-Seq_DFB_Human2.78382670
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63224616
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49857585
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35480182
17EZH2_22144423_ChIP-Seq_EOC_Human2.24208401
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12699860
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.12638392
20P300_19829295_ChIP-Seq_ESCs_Human2.01955839
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2542213
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97760864
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93982905
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90918232
25ER_23166858_ChIP-Seq_MCF-7_Human1.90786506
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89414337
27SMAD4_21799915_ChIP-Seq_A2780_Human1.85988496
28FUS_26573619_Chip-Seq_HEK293_Human1.85069624
29STAT3_23295773_ChIP-Seq_U87_Human1.83836744
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.83076335
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82429600
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73805710
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72129591
34HTT_18923047_ChIP-ChIP_STHdh_Human1.71839329
35EWS_26573619_Chip-Seq_HEK293_Human1.67555062
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.67231489
37TCF4_23295773_ChIP-Seq_U87_Human1.65837727
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62845222
39AR_25329375_ChIP-Seq_VCAP_Human1.60314112
40CBP_20019798_ChIP-Seq_JUKART_Human1.59258930
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59258930
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57688360
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.55118764
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54304654
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.53869529
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52941361
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47511739
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44964236
49TCF4_22108803_ChIP-Seq_LS180_Human1.44860424
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41626888
51GATA1_22025678_ChIP-Seq_K562_Human1.40751405
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37035597
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36810448
54RUNX2_22187159_ChIP-Seq_PCA_Human1.34162209
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32126921
56NANOG_19829295_ChIP-Seq_ESCs_Human1.31390180
57SOX2_19829295_ChIP-Seq_ESCs_Human1.31390180
58HNF4A_19822575_ChIP-Seq_HepG2_Human1.31122052
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30650001
60REST_21632747_ChIP-Seq_MESCs_Mouse1.29450992
61CLOCK_20551151_ChIP-Seq_293T_Human1.29247508
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29002065
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28105100
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28105100
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27920283
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27169774
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.27126193
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24202673
69DROSHA_22980978_ChIP-Seq_HELA_Human1.23241317
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22211071
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21790773
72TP53_22573176_ChIP-Seq_HFKS_Human1.21559913
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.20992120
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18620797
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.18464162
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16792738
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.16792738
78AHR_22903824_ChIP-Seq_MCF-7_Human1.16603120
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16038639
80P53_22387025_ChIP-Seq_ESCs_Mouse1.15981923
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14548657
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14043175
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14041913
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12441366
85AR_21572438_ChIP-Seq_LNCaP_Human1.12035856
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11897267
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11611812
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.11005308
89KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10368179
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.09941216
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.09307720
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08083755
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07545296
94NCOR_22424771_ChIP-Seq_293T_Human1.06973427
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.05678580
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03925112
97P300_18555785_Chip-Seq_ESCs_Mouse1.02915614
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.02216045
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01785475
100ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01454966
101TBL1_22424771_ChIP-Seq_293T_Human1.01139086
102BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99360737
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99161249
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93642161
105SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92932017
106AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92844539
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91748856
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87038912
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87038912
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86688793
111TAF15_26573619_Chip-Seq_HEK293_Human0.85153695
112GATA4_25053715_ChIP-Seq_YYC3_Human0.84338074
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84179503
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83899250
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83892646
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80641180
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80602465
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77965704
119IRF8_22096565_ChIP-ChIP_GC-B_Human0.77870324
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.73824822
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71223580
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68017735
123* STAT1_17558387_ChIP-Seq_HELA_Human0.67614336
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66942930
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66143689
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.66075739
127RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65843044
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65257562
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.65079681
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.65079197
131NFE2_27457419_Chip-Seq_LIVER_Mouse0.64802640
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.64681161
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.62094149
134CEBPB_22108803_ChIP-Seq_LS180_Human0.61898557
135IRF1_19129219_ChIP-ChIP_H3396_Human0.61279063
136CRX_20693478_ChIP-Seq_RETINA_Mouse0.60681105
137* AR_20517297_ChIP-Seq_VCAP_Human0.60677947
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60504339
139ESR1_15608294_ChIP-ChIP_MCF-7_Human0.60332893
140* RARA_24833708_ChIP-Seq_LIVER_Mouse0.59505352
141ESR2_21235772_ChIP-Seq_MCF-7_Human0.58856171
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.58014438
143RARB_24833708_ChIP-Seq_LIVER_Mouse0.57158640
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.56995532
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.56667309
146OCT4_21477851_ChIP-Seq_ESCs_Mouse0.55730311
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55265018
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.55196761
149E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.55190571
150SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.54846667
151BCAT_22108803_ChIP-Seq_LS180_Human0.53942276
152ESET_19884257_ChIP-Seq_ESCs_Mouse0.53170909
153CBP_21632823_ChIP-Seq_H3396_Human0.52976170
154* CDX2_22108803_ChIP-Seq_LS180_Human0.52143870
155MYC_19915707_ChIP-ChIP_AK7_Human0.52016460
156P53_21459846_ChIP-Seq_SAOS-2_Human0.51928143
157RUNX1_27457419_Chip-Seq_LIVER_Mouse0.50431799
158FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49272700
159ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.48983523
160FOXH1_21741376_ChIP-Seq_EPCs_Human0.48728069
161PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48227237
162ESR1_21235772_ChIP-Seq_MCF-7_Human0.47070477
163FOXM1_26456572_ChIP-Seq_MCF-7_Human0.46964288
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.46291750
165CDX2_20551321_ChIP-Seq_CACO-2_Human0.46169628
166PPAR_26484153_Chip-Seq_NCI-H1993_Human0.45141797
167EGR1_19032775_ChIP-ChIP_M12_Human0.44963720
168SOX2_20726797_ChIP-Seq_SW620_Human0.44451724
169FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43462871
170SMAD4_21741376_ChIP-Seq_EPCs_Human0.42620399
171SMAD1_18555785_Chip-Seq_ESCs_Mouse0.42082805
172SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.41354337
173EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.40171866
174GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.39940517
175MYC_27129775_Chip-Seq_CORNEA_Mouse0.39021442
176KDM2B_26808549_Chip-Seq_REH_Human0.38781204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.35226306
2MP0005360_urolithiasis7.54251696
3MP0005085_abnormal_gallbladder_physiolo6.52263368
4MP0005365_abnormal_bile_salt6.13816772
5MP0008875_abnormal_xenobiotic_pharmacok5.36306226
6MP0003806_abnormal_nucleotide_metabolis4.08619253
7MP0003252_abnormal_bile_duct3.69343054
8MP0010329_abnormal_lipoprotein_level3.48739364
9MP0005083_abnormal_biliary_tract3.15729308
10MP0009840_abnormal_foam_cell3.12755582
11MP0005332_abnormal_amino_acid2.84251066
12MP0003195_calcinosis2.73255375
13MP0005551_abnormal_eye_electrophysiolog2.55942415
14MP0001666_abnormal_nutrient_absorption2.53313163
15MP0009046_muscle_twitch2.49086668
16MP0001968_abnormal_touch/_nociception2.37991506
17MP0008877_abnormal_DNA_methylation2.32655127
18MP0000569_abnormal_digit_pigmentation2.31232143
19MP0002736_abnormal_nociception_after2.29634232
20MP0004019_abnormal_vitamin_homeostasis2.25364433
21MP0003191_abnormal_cellular_cholesterol2.19129331
22MP0001501_abnormal_sleep_pattern2.16047670
23MP0004043_abnormal_pH_regulation2.09533095
24MP0009745_abnormal_behavioral_response2.07271782
25MP0002118_abnormal_lipid_homeostasis2.05288815
26MP0002138_abnormal_hepatobiliary_system2.05237772
27MP0000609_abnormal_liver_physiology2.03096353
28MP0005253_abnormal_eye_physiology1.88965470
29MP0001984_abnormal_olfaction1.87818551
30MP0002638_abnormal_pupillary_reflex1.87635684
31MP0009697_abnormal_copulation1.85998964
32MP0003868_abnormal_feces_composition1.82659938
33MP0010386_abnormal_urinary_bladder1.81033303
34MP0002102_abnormal_ear_morphology1.75396838
35MP0003787_abnormal_imprinting1.73145502
36MP0006072_abnormal_retinal_apoptosis1.71931834
37MP0001986_abnormal_taste_sensitivity1.71859331
38MP0001486_abnormal_startle_reflex1.70232055
39MP0001485_abnormal_pinna_reflex1.69724203
40MP0002272_abnormal_nervous_system1.69625170
41MP0005319_abnormal_enzyme/_coenzyme1.69230138
42MP0001764_abnormal_homeostasis1.67130275
43MP0009780_abnormal_chondrocyte_physiolo1.65600424
44MP0006276_abnormal_autonomic_nervous1.64325690
45MP0005645_abnormal_hypothalamus_physiol1.63461307
46MP0002653_abnormal_ependyma_morphology1.61309014
47MP0002909_abnormal_adrenal_gland1.51364366
48MP0005451_abnormal_body_composition1.49861592
49MP0004147_increased_porphyrin_level1.46995395
50MP0005584_abnormal_enzyme/coenzyme_acti1.46750368
51MP0002064_seizures1.45768151
52MP0003880_abnormal_central_pattern1.45688079
53MP0002735_abnormal_chemical_nociception1.43756600
54MP0003136_yellow_coat_color1.42587990
55MP0003186_abnormal_redox_activity1.39778100
56MP0003646_muscle_fatigue1.37746339
57MP0002572_abnormal_emotion/affect_behav1.37085562
58MP0003011_delayed_dark_adaptation1.36810183
59MP0003878_abnormal_ear_physiology1.33298055
60MP0005377_hearing/vestibular/ear_phenot1.33298055
61MP0003656_abnormal_erythrocyte_physiolo1.31395302
62MP0008057_abnormal_DNA_replication1.29908356
63MP0000383_abnormal_hair_follicle1.29260790
64MP0000631_abnormal_neuroendocrine_gland1.26596621
65MP0004885_abnormal_endolymph1.26469301
66MP0005647_abnormal_sex_gland1.25689716
67MP0004133_heterotaxia1.24229807
68MP0001970_abnormal_pain_threshold1.24101007
69MP0005386_behavior/neurological_phenoty1.23382901
70MP0004924_abnormal_behavior1.23382901
71MP0009643_abnormal_urine_homeostasis1.23075000
72MP0004142_abnormal_muscle_tone1.20338534
73MP0003879_abnormal_hair_cell1.15876170
74MP0005379_endocrine/exocrine_gland_phen1.14086327
75MP0003137_abnormal_impulse_conducting1.13675047
76MP0009764_decreased_sensitivity_to1.11831121
77MP0004215_abnormal_myocardial_fiber1.11199973
78MP0002557_abnormal_social/conspecific_i1.10376362
79MP0003635_abnormal_synaptic_transmissio1.10208652
80MP0002229_neurodegeneration1.09511971
81MP0002733_abnormal_thermal_nociception1.08996701
82MP0000372_irregular_coat_pigmentation1.08285687
83MP0000598_abnormal_liver_morphology1.06121370
84MP0002876_abnormal_thyroid_physiology1.04266645
85MP0002938_white_spotting1.03728192
86MP0004782_abnormal_surfactant_physiolog1.03664113
87MP0002067_abnormal_sensory_capabilities1.03032322
88MP0002693_abnormal_pancreas_physiology1.02484521
89MP0009763_increased_sensitivity_to1.02348486
90MP0002254_reproductive_system_inflammat1.01880247
91MP0003633_abnormal_nervous_system1.01755033
92MP0002734_abnormal_mechanical_nocicepti0.99866555
93MP0004145_abnormal_muscle_electrophysio0.99618519
94MP0001963_abnormal_hearing_physiology0.98098174
95MP0003890_abnormal_embryonic-extraembry0.97895458
96MP0010368_abnormal_lymphatic_system0.97757030
97MP0002063_abnormal_learning/memory/cond0.96909770
98MP0005084_abnormal_gallbladder_morpholo0.95710088
99MP0005636_abnormal_mineral_homeostasis0.95274844
100MP0003950_abnormal_plasma_membrane0.94161839
101MP0005174_abnormal_tail_pigmentation0.93998298
102MP0002160_abnormal_reproductive_system0.93192072
103MP0005410_abnormal_fertilization0.91612661
104MP0000604_amyloidosis0.90249603
105MP0005670_abnormal_white_adipose0.89390887
106MP0003698_abnormal_male_reproductive0.88944909
107MP0001944_abnormal_pancreas_morphology0.88410335
108MP0003045_fibrosis0.88125125
109MP0008469_abnormal_protein_level0.86288731
110MP0005408_hypopigmentation0.84976387
111MP0009642_abnormal_blood_homeostasis0.83406609
112MP0003718_maternal_effect0.81857886
113MP0002234_abnormal_pharynx_morphology0.81196814
114MP0000538_abnormal_urinary_bladder0.80117837
115MP0001765_abnormal_ion_homeostasis0.79745191
116MP0002163_abnormal_gland_morphology0.79128840
117MP0009765_abnormal_xenobiotic_induced0.77455805
118MP0005376_homeostasis/metabolism_phenot0.77384523
119MP0003690_abnormal_glial_cell0.73699056
120MP0003705_abnormal_hypodermis_morpholog0.71358729
121MP0006036_abnormal_mitochondrial_physio0.70375086
122MP0002078_abnormal_glucose_homeostasis0.70342207
123MP0003724_increased_susceptibility_to0.69110038
124MP0005395_other_phenotype0.67203379
125MP0002132_abnormal_respiratory_system0.66656120
126MP0002971_abnormal_brown_adipose0.65879640
127MP0000639_abnormal_adrenal_gland0.64567318
128MP0005535_abnormal_body_temperature0.62976482
129MP0005220_abnormal_exocrine_pancreas0.59831992
130MP0005266_abnormal_metabolism0.59015155
131MP0005334_abnormal_fat_pad0.58452120
132MP0001661_extended_life_span0.55752214
133MP0001756_abnormal_urination0.55439765
134MP0004381_abnormal_hair_follicle0.52437774
135MP0004130_abnormal_muscle_cell0.51950249
136MP0009053_abnormal_anal_canal0.51162738
137MP0003329_amyloid_beta_deposits0.48937496
138MP0000579_abnormal_nail_morphology0.48491410
139MP0002822_catalepsy0.47874430
140MP0002136_abnormal_kidney_physiology0.46642929
141MP0005448_abnormal_energy_balance0.46215223
142MP0008874_decreased_physiological_sensi0.44392214
143MP0005248_abnormal_Harderian_gland0.43873745
144MP0005166_decreased_susceptibility_to0.42234220
145MP0008873_increased_physiological_sensi0.40717308
146MP0006035_abnormal_mitochondrial_morpho0.40405849
147MP0005464_abnormal_platelet_physiology0.40276677
148MP0002168_other_aberrant_phenotype0.39979147
149MP0008872_abnormal_physiological_respon0.39967165
150MP0002928_abnormal_bile_duct0.38043662
151MP0003953_abnormal_hormone_level0.37286898
152MP0003638_abnormal_response/metabolism_0.35960149
153MP0005646_abnormal_pituitary_gland0.34716573
154MP0009115_abnormal_fat_cell0.32526198
155MP0005167_abnormal_blood-brain_barrier0.32438960
156MP0006082_CNS_inflammation0.31596077
157MP0003075_altered_response_to0.30883998
158MP0002837_dystrophic_cardiac_calcinosis0.30465153
159MP0000427_abnormal_hair_cycle0.28992055
160MP0000230_abnormal_systemic_arterial0.28819234
161MP0000249_abnormal_blood_vessel0.27880898
162MP0005666_abnormal_adipose_tissue0.27399647
163MP0001243_abnormal_dermal_layer0.26808884
164MP0005164_abnormal_response_to0.26702324
165MP0002796_impaired_skin_barrier0.26200919
166MP0001845_abnormal_inflammatory_respons0.24110188
167MP0002295_abnormal_pulmonary_circulatio0.23288000
168MP0002060_abnormal_skin_morphology0.22924921
169MP0005595_abnormal_vascular_smooth0.22901843
170MP0001881_abnormal_mammary_gland0.22864508
171MP0001177_atelectasis0.22773077
172MP0003699_abnormal_female_reproductive0.22520436

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.48388442
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.38203788
3Intrahepatic cholestasis (HP:0001406)7.24010473
4Prolonged partial thromboplastin time (HP:0003645)6.82624420
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.56775463
6Hypobetalipoproteinemia (HP:0003563)6.12224149
7Xanthomatosis (HP:0000991)6.06590331
8Complement deficiency (HP:0004431)5.46605700
9Hyperlipoproteinemia (HP:0010980)5.40689205
10Joint hemorrhage (HP:0005261)4.96406364
11Pancreatic cysts (HP:0001737)4.89647795
12Abnormal ciliary motility (HP:0012262)4.65711174
13Pancreatic fibrosis (HP:0100732)4.63042674
14Dynein arm defect of respiratory motile cilia (HP:0012255)4.58622382
15Absent/shortened dynein arms (HP:0200106)4.58622382
16Hypolipoproteinemia (HP:0010981)4.57387758
17Abnormal respiratory epithelium morphology (HP:0012253)4.42786987
18Abnormal respiratory motile cilium morphology (HP:0005938)4.42786987
19Abnormal respiratory motile cilium physiology (HP:0012261)4.40332015
20Hyperammonemia (HP:0001987)4.39887116
21Abnormality of methionine metabolism (HP:0010901)4.39691696
22Epidermoid cyst (HP:0200040)4.34564305
23True hermaphroditism (HP:0010459)4.33404604
24Hyperglycinemia (HP:0002154)4.33203138
25Abnormality of sulfur amino acid metabolism (HP:0004339)4.27842114
26Abnormality of glutamine family amino acid metabolism (HP:0010902)4.25139935
27Ketosis (HP:0001946)4.18827491
28Abnormality of the common coagulation pathway (HP:0010990)4.17826121
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.17102972
30Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15626490
31Fat malabsorption (HP:0002630)4.12867800
32Abnormality of pyrimidine metabolism (HP:0004353)4.07525618
33Hypoalphalipoproteinemia (HP:0003233)4.04221121
34Conjugated hyperbilirubinemia (HP:0002908)3.98832696
35Abnormality of serine family amino acid metabolism (HP:0010894)3.93082032
36Abnormality of glycine metabolism (HP:0010895)3.93082032
37Hyperglycinuria (HP:0003108)3.92587470
38Abnormality of complement system (HP:0005339)3.87277482
39Hypoglycemic coma (HP:0001325)3.82424136
40Abnormality of midbrain morphology (HP:0002418)3.75105991
41Molar tooth sign on MRI (HP:0002419)3.75105991
42Abnormality of the intrinsic pathway (HP:0010989)3.73966990
43Gaze-evoked nystagmus (HP:0000640)3.71998056
44Rhinitis (HP:0012384)3.68708788
45Nephronophthisis (HP:0000090)3.68333073
46Progressive cerebellar ataxia (HP:0002073)3.64255475
47Genetic anticipation (HP:0003743)3.60739328
48Cystic liver disease (HP:0006706)3.47794817
49Abnormality of fatty-acid metabolism (HP:0004359)3.46433395
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39933295
51Abnormality of the renal cortex (HP:0011035)3.37800125
52Hypercholesterolemia (HP:0003124)3.35157213
53Hyperbilirubinemia (HP:0002904)3.33915210
54Abnormality of the renal medulla (HP:0100957)3.27433803
55Hyperventilation (HP:0002883)3.27048815
56Steatorrhea (HP:0002570)3.21285968
57Chronic hepatic failure (HP:0100626)3.19548931
58Medial flaring of the eyebrow (HP:0010747)3.17317048
59Delayed CNS myelination (HP:0002188)3.14260675
60Abnormality of nucleobase metabolism (HP:0010932)3.11001550
61Hypochromic microcytic anemia (HP:0004840)3.07004321
62Abnormality of serum amino acid levels (HP:0003112)3.04327838
63Hepatocellular carcinoma (HP:0001402)3.01681932
64Decreased circulating renin level (HP:0003351)3.00311677
65Attenuation of retinal blood vessels (HP:0007843)2.96847000
66Tubular atrophy (HP:0000092)2.92448874
67Ketoacidosis (HP:0001993)2.88643592
68Abolished electroretinogram (ERG) (HP:0000550)2.88524678
69Spontaneous abortion (HP:0005268)2.86142179
70Systemic lupus erythematosus (HP:0002725)2.85144065
71Congenital stationary night blindness (HP:0007642)2.82424856
72Metabolic acidosis (HP:0001942)2.76323076
73Myocardial infarction (HP:0001658)2.72496687
74Hypoglycemic seizures (HP:0002173)2.71958225
75Bronchiectasis (HP:0002110)2.71930808
76Gait imbalance (HP:0002141)2.68547509
77Vascular calcification (HP:0004934)2.63713002
78Acanthocytosis (HP:0001927)2.63035568
79Abnormality of purine metabolism (HP:0004352)2.62739515
80Congenital primary aphakia (HP:0007707)2.61600310
81Recurrent gram-negative bacterial infections (HP:0005420)2.60447568
82Focal seizures (HP:0007359)2.59709867
83Lethargy (HP:0001254)2.54931927
84Dicarboxylic aciduria (HP:0003215)2.53710626
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53710626
86Chronic bronchitis (HP:0004469)2.53152030
87Dialeptic seizures (HP:0011146)2.51763456
88Gout (HP:0001997)2.50616346
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.50079055
90Congenital hepatic fibrosis (HP:0002612)2.49784718
91Skin nodule (HP:0200036)2.48403556
92Febrile seizures (HP:0002373)2.44478866
93Abnormal gallbladder morphology (HP:0012437)2.43711496
94Furrowed tongue (HP:0000221)2.42497830
95Abnormal drinking behavior (HP:0030082)2.40395636
96Polydipsia (HP:0001959)2.40395636
97Bony spicule pigmentary retinopathy (HP:0007737)2.37695792
98Fair hair (HP:0002286)2.37388084
99Focal motor seizures (HP:0011153)2.36746687
100Spastic diplegia (HP:0001264)2.36439437
101Enlarged kidneys (HP:0000105)2.35744746
102Glomerulonephritis (HP:0000099)2.35337440
103Sclerocornea (HP:0000647)2.34584718
104Abnormal gallbladder physiology (HP:0012438)2.34065491
105Cholecystitis (HP:0001082)2.34065491
106Cerebral edema (HP:0002181)2.32716222
107Cholelithiasis (HP:0001081)2.32182884
108Occipital encephalocele (HP:0002085)2.32000573
109Decreased central vision (HP:0007663)2.31977611
110Nephrogenic diabetes insipidus (HP:0009806)2.31795329
111Absence seizures (HP:0002121)2.30744496
112Absent speech (HP:0001344)2.30617925
113Cardiovascular calcification (HP:0011915)2.30455985
114Mitral stenosis (HP:0001718)2.24911402
115Irritability (HP:0000737)2.24600707
116Brushfield spots (HP:0001088)2.24314933
117Generalized aminoaciduria (HP:0002909)2.24195550
118Large for gestational age (HP:0001520)2.23344569
119Hypothermia (HP:0002045)2.21482668
120Male pseudohermaphroditism (HP:0000037)2.20710897
121Neonatal onset (HP:0003623)2.19296161
122Tubulointerstitial nephritis (HP:0001970)2.18949156
123Pendular nystagmus (HP:0012043)2.18796393
124Amyloidosis (HP:0011034)2.18126947
125Genital tract atresia (HP:0001827)2.18094507
126Postaxial foot polydactyly (HP:0001830)2.17792962
127Hypophosphatemic rickets (HP:0004912)2.16850454
128Congenital sensorineural hearing impairment (HP:0008527)2.14095663
129Abnormality of macular pigmentation (HP:0008002)2.13646001
130Type II lissencephaly (HP:0007260)2.13606744
131Intestinal atresia (HP:0011100)2.13500224
132Broad-based gait (HP:0002136)2.12851435
133Hemiparesis (HP:0001269)2.11328428
134Esophageal varix (HP:0002040)2.11290586
135Aplasia/Hypoplasia of the tibia (HP:0005772)2.11023529
136Aplasia/Hypoplasia of the fovea (HP:0008060)2.10383054
137Hypoplasia of the fovea (HP:0007750)2.10383054
138Hyperinsulinemic hypoglycemia (HP:0000825)2.09951832
139Anencephaly (HP:0002323)2.09732037
140Pancreatitis (HP:0001733)2.09091315
141Hydroxyprolinuria (HP:0003080)2.08653480
142Abnormality of proline metabolism (HP:0010907)2.08653480
143Renal cortical cysts (HP:0000803)2.08287468
144Gingival bleeding (HP:0000225)2.08050861
145Vaginal atresia (HP:0000148)2.06708002
146Retinitis pigmentosa (HP:0000510)2.05278049
147Increased corneal curvature (HP:0100692)2.03867394
148Keratoconus (HP:0000563)2.03867394
149Protruding tongue (HP:0010808)2.03812182
150Menorrhagia (HP:0000132)2.03686211
151Abnormal rod and cone electroretinograms (HP:0008323)2.02771101
152Poikilocytosis (HP:0004447)2.01731560
153Abnormality of the gallbladder (HP:0005264)2.00315168
154Vomiting (HP:0002013)1.99219343
155Opisthotonus (HP:0002179)1.97911702
156Sensorimotor neuropathy (HP:0007141)1.97735029
157Inability to walk (HP:0002540)1.95234542
158Rickets (HP:0002748)1.95169219
159Thrombophlebitis (HP:0004418)1.94016799
160Late onset (HP:0003584)1.92587274
161Clumsiness (HP:0002312)1.92006968
162Alkalosis (HP:0001948)1.91594497
163Malnutrition (HP:0004395)1.88663996
164Symptomatic seizures (HP:0011145)1.85388275
165Hemorrhage of the eye (HP:0011885)1.84234127
166Oculomotor apraxia (HP:0000657)1.83879277
167Hyperglycemia (HP:0003074)1.82338540
168Bile duct proliferation (HP:0001408)1.82301294
169Abnormal biliary tract physiology (HP:0012439)1.82301294
170Abnormality of renin-angiotensin system (HP:0000847)1.82117993
171Postaxial hand polydactyly (HP:0001162)1.80470084
172Polyuria (HP:0000103)1.80299698
173Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80086445
174Elevated hepatic transaminases (HP:0002910)1.79789261
175Action tremor (HP:0002345)1.79077911
176Abnormality of vitamin metabolism (HP:0100508)1.78611827
177Tubulointerstitial abnormality (HP:0001969)1.78413126
178Widely spaced teeth (HP:0000687)1.78039481
179Abnormal enzyme/coenzyme activity (HP:0012379)1.77900014
180Progressive inability to walk (HP:0002505)1.77684782
181Hyperkalemia (HP:0002153)1.76511583
182Generalized hypopigmentation of hair (HP:0011358)1.76378452
183Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75345067
184Poor coordination (HP:0002370)1.75049860
185Chorioretinal atrophy (HP:0000533)1.74092811
186Abnormality of iron homeostasis (HP:0011031)1.73685586
187Aplasia/Hypoplasia of the spleen (HP:0010451)1.71483127
188Chronic sinusitis (HP:0011109)1.71455950
189Constricted visual fields (HP:0001133)1.70039757
190Abnormality of the fovea (HP:0000493)1.68837195
191Disproportionate short-trunk short stature (HP:0003521)1.68445722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.11840843
2SIK14.68040866
3FGFR44.00447283
4INSRR3.65082593
5TIE13.37006022
6TAOK33.36035327
7ERBB43.30779112
8ERN13.22069814
9ACVR1B2.82762082
10ADRBK22.55464636
11MAP4K22.46267453
12WNK32.28304574
13CASK2.22154833
14OXSR12.21713634
15MAP2K42.07223716
16MAPK111.99922159
17PIK3CG1.96276451
18MAPK151.93630276
19MAP3K41.90024061
20PINK11.86327016
21ZAK1.82317221
22CDK191.82096442
23MST1R1.71336361
24MAP3K141.64804260
25LATS11.60229856
26MAPK131.57033621
27NTRK31.56711765
28MST41.55435840
29NEK91.55130190
30GRK11.53250051
31ABL21.41463459
32TYK21.41056163
33FRK1.38759726
34FLT31.38332472
35TNIK1.37305107
36MKNK21.32650405
37FGFR21.31120812
38IRAK21.30834099
39DAPK21.29346809
40STK391.26439436
41PHKG21.26150849
42PHKG11.26150849
43PRKAA21.22315247
44TNK21.18947918
45WNK41.15158773
46JAK11.14058160
47MARK11.07852146
48PAK31.07156619
49PRKCE1.06822325
50PKN11.06406401
51PTK61.04491251
52FER1.03623340
53CSK1.01501265
54JAK21.01212940
55STK38L0.96917013
56CSNK1G10.96494208
57PKN20.96481841
58PRKCZ0.95817087
59MAPK40.93385174
60ADRBK10.93133557
61SGK20.91663219
62KDR0.90319666
63TBK10.87393871
64EPHB10.87115146
65ERBB20.86808896
66PRKCQ0.86229967
67MAP2K70.85342822
68MAP3K70.84774085
69SGK2230.84159566
70SGK4940.84159566
71BRAF0.83675315
72CAMK2G0.81835456
73PTK2B0.81541664
74TRIM280.81532462
75ERBB30.80702035
76TXK0.80043817
77TGFBR20.79812243
78MAPK120.76220452
79IRAK30.76168425
80SGK30.75939698
81GSK3A0.73814936
82PRKACG0.73373814
83PLK20.70979945
84CSNK1A1L0.70228534
85BRSK20.68853798
86IKBKE0.68769395
87PIK3CA0.68082464
88TRIB30.67614776
89NLK0.67213904
90MAPK70.67210326
91STK110.67100436
92NUAK10.66977214
93OBSCN0.66654355
94PRKAA10.65971198
95GRK60.64388821
96CSNK1G30.63814699
97PTK20.63324317
98CAMK2A0.62219534
99AKT30.61777152
100TEC0.61730000
101MET0.61238489
102MAP3K30.60778424
103CAMK1D0.60558526
104MUSK0.59646914
105TRPM70.59126952
106STK380.58889226
107MAPKAPK30.58234755
108PDPK10.56803058
109MAP2K60.55913785
110MAP2K20.52726262
111PRKD30.51852215
112TGFBR10.51498688
113EPHA40.50676980
114PRKCG0.50619126
115TAF10.49401557
116MAP3K130.49061932
117CSNK1G20.48394867
118MYLK0.47750287
119NME10.46835765
120CAMKK20.46831835
121IGF1R0.46343547
122MAP3K60.45644716
123NTRK20.44245206
124MKNK10.43929363
125CSNK1A10.43829937
126RIPK10.43360646
127CSNK1D0.43029695
128ITK0.41618827
129BCR0.41360808
130CDK60.40695839
131TLK10.39169074
132GRK50.38610021
133MAP2K10.37663440
134CAMK10.36190231
135IRAK10.33844528
136MAP2K30.33555844
137MAPKAPK50.32793756
138STK30.32685835
139CDK30.32544499
140EGFR0.32080680
141DYRK20.31799541
142SGK10.31674810
143PRKCH0.31444677
144PRKACB0.31365282
145PNCK0.31005091
146CAMK2D0.30745547
147PRKCA0.30737672
148BMPR1B0.30708369
149FGFR30.29641130
150ABL10.29551812
151EPHA30.28502092
152PRKACA0.28234877
153PRKG10.25903422
154PDK10.25862065
155BMPR20.25482415
156BMX0.25309117
157CSF1R0.25097180
158CAMK40.23002010
159CHUK0.22548431

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.57155517
2Nitrogen metabolism_Homo sapiens_hsa009103.34820160
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30105435
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27472737
5Arginine biosynthesis_Homo sapiens_hsa002202.97768647
6Complement and coagulation cascades_Homo sapiens_hsa046102.79841138
7Tryptophan metabolism_Homo sapiens_hsa003802.79702363
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69675078
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58675977
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53744232
11Fatty acid degradation_Homo sapiens_hsa000712.40615420
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35899980
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.33683309
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24723615
15Butanoate metabolism_Homo sapiens_hsa006502.19847192
16Peroxisome_Homo sapiens_hsa041462.15170548
17Phototransduction_Homo sapiens_hsa047442.12904696
18Histidine metabolism_Homo sapiens_hsa003402.11494882
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.09669463
20Chemical carcinogenesis_Homo sapiens_hsa052042.06344360
21Steroid hormone biosynthesis_Homo sapiens_hsa001402.04267021
22Nicotine addiction_Homo sapiens_hsa050331.89271471
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88200231
24Propanoate metabolism_Homo sapiens_hsa006401.85073027
25PPAR signaling pathway_Homo sapiens_hsa033201.84393708
26Retinol metabolism_Homo sapiens_hsa008301.83962592
27Caffeine metabolism_Homo sapiens_hsa002321.81410352
28beta-Alanine metabolism_Homo sapiens_hsa004101.79275758
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75245241
30Staphylococcus aureus infection_Homo sapiens_hsa051501.71771924
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.69822858
32Phenylalanine metabolism_Homo sapiens_hsa003601.66556409
33Fatty acid metabolism_Homo sapiens_hsa012121.65265220
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63422719
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55987362
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54832808
37Tyrosine metabolism_Homo sapiens_hsa003501.53384600
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52839865
39Selenocompound metabolism_Homo sapiens_hsa004501.49684360
40Bile secretion_Homo sapiens_hsa049761.45204243
41Sulfur metabolism_Homo sapiens_hsa009201.38925840
42Fatty acid elongation_Homo sapiens_hsa000621.37382963
43Olfactory transduction_Homo sapiens_hsa047401.33912299
44Taste transduction_Homo sapiens_hsa047421.33730021
45Pyruvate metabolism_Homo sapiens_hsa006201.30173337
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30000812
47Steroid biosynthesis_Homo sapiens_hsa001001.29965165
48Morphine addiction_Homo sapiens_hsa050321.24944949
49Starch and sucrose metabolism_Homo sapiens_hsa005001.23726290
50Insulin secretion_Homo sapiens_hsa049111.23511815
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.22712136
52Circadian entrainment_Homo sapiens_hsa047131.21107601
53ABC transporters_Homo sapiens_hsa020101.18743820
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17994259
55GABAergic synapse_Homo sapiens_hsa047271.15347334
56Vitamin B6 metabolism_Homo sapiens_hsa007501.14853888
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14681377
58Sphingolipid metabolism_Homo sapiens_hsa006001.14273409
59Folate biosynthesis_Homo sapiens_hsa007901.09518941
60Glutamatergic synapse_Homo sapiens_hsa047241.08744722
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.08061161
62Serotonergic synapse_Homo sapiens_hsa047261.07105285
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06133395
64Salivary secretion_Homo sapiens_hsa049701.04469190
65Fat digestion and absorption_Homo sapiens_hsa049751.04204676
66Biosynthesis of amino acids_Homo sapiens_hsa012301.04004280
67Arginine and proline metabolism_Homo sapiens_hsa003301.03286997
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01527290
69Carbon metabolism_Homo sapiens_hsa012000.95585529
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94616378
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.90050251
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87859431
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87535032
74Vitamin digestion and absorption_Homo sapiens_hsa049770.86796591
75Circadian rhythm_Homo sapiens_hsa047100.86509692
76Protein export_Homo sapiens_hsa030600.84298036
77Homologous recombination_Homo sapiens_hsa034400.83396570
78Sulfur relay system_Homo sapiens_hsa041220.82561685
79Calcium signaling pathway_Homo sapiens_hsa040200.76300919
80Glutathione metabolism_Homo sapiens_hsa004800.75314111
81Lysine degradation_Homo sapiens_hsa003100.73682444
82Basal transcription factors_Homo sapiens_hsa030220.72642153
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71754950
84Dorso-ventral axis formation_Homo sapiens_hsa043200.69114294
85One carbon pool by folate_Homo sapiens_hsa006700.67295075
86Dopaminergic synapse_Homo sapiens_hsa047280.62036649
87Collecting duct acid secretion_Homo sapiens_hsa049660.61463062
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59886500
89Glycerolipid metabolism_Homo sapiens_hsa005610.59246456
90Fanconi anemia pathway_Homo sapiens_hsa034600.58225330
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.57302027
92Long-term depression_Homo sapiens_hsa047300.56641553
93Renin secretion_Homo sapiens_hsa049240.51488029
94RNA polymerase_Homo sapiens_hsa030200.50988770
95Mineral absorption_Homo sapiens_hsa049780.50606186
96Metabolic pathways_Homo sapiens_hsa011000.47992439
97Amphetamine addiction_Homo sapiens_hsa050310.47908569
98cAMP signaling pathway_Homo sapiens_hsa040240.45262650
99Cocaine addiction_Homo sapiens_hsa050300.42569808
100Fatty acid biosynthesis_Homo sapiens_hsa000610.42447834
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41768422
102Gastric acid secretion_Homo sapiens_hsa049710.41509534
103Prion diseases_Homo sapiens_hsa050200.41243515
104Pentose phosphate pathway_Homo sapiens_hsa000300.39315342
105Cholinergic synapse_Homo sapiens_hsa047250.37820992
106Pancreatic secretion_Homo sapiens_hsa049720.35600112
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35059294
108Oxytocin signaling pathway_Homo sapiens_hsa049210.34493998
109Linoleic acid metabolism_Homo sapiens_hsa005910.31191278
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29628264
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26817500
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24498516
113Fructose and mannose metabolism_Homo sapiens_hsa000510.20200774
114Galactose metabolism_Homo sapiens_hsa000520.19675873
115Insulin resistance_Homo sapiens_hsa049310.18121241
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.14292122
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.11742559
118Ovarian steroidogenesis_Homo sapiens_hsa049130.11415680
119Glucagon signaling pathway_Homo sapiens_hsa049220.06333346
120Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2630513
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.2578996
122Pertussis_Homo sapiens_hsa05133-0.2569959
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.2472892
124Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2433734
125Renin-angiotensin system_Homo sapiens_hsa04614-0.2355636
126Amoebiasis_Homo sapiens_hsa05146-0.2151608
127Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2044096
128Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1941369
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1851654
130Hepatitis C_Homo sapiens_hsa05160-0.1664627
131Regulation of autophagy_Homo sapiens_hsa04140-0.1540099
132Insulin signaling pathway_Homo sapiens_hsa04910-0.1499239
133Ether lipid metabolism_Homo sapiens_hsa00565-0.1246698
134African trypanosomiasis_Homo sapiens_hsa05143-0.1225118
135Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1146947
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0791871
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0755178
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0627031
139AMPK signaling pathway_Homo sapiens_hsa04152-0.0258249
140Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0241183

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