FAM46A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory receptor cell differentiation (GO:0042491)4.71279244
2neutrophil activation involved in immune response (GO:0002283)4.50806838
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46738777
4regulation of type B pancreatic cell apoptotic process (GO:2000674)4.29619325
5negative regulation of complement activation (GO:0045916)4.26962434
6production of molecular mediator involved in inflammatory response (GO:0002532)4.15618449
7positive regulation by symbiont of host defense response (GO:0052509)4.11174102
8modulation by symbiont of host defense response (GO:0052031)4.11174102
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.11174102
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.11174102
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.11174102
12modulation by symbiont of host immune response (GO:0052553)4.11174102
13regulation of hexokinase activity (GO:1903299)4.10519515
14regulation of glucokinase activity (GO:0033131)4.10519515
15signal peptide processing (GO:0006465)4.05262356
16eosinophil chemotaxis (GO:0048245)4.00767331
17respiratory burst (GO:0045730)3.87372029
18response to peptidoglycan (GO:0032494)3.86543594
19negative regulation of protein activation cascade (GO:2000258)3.85878589
20keratan sulfate catabolic process (GO:0042340)3.85689630
21Golgi transport vesicle coating (GO:0048200)3.76691192
22COPI coating of Golgi vesicle (GO:0048205)3.76691192
23regulation of interferon-beta biosynthetic process (GO:0045357)3.70981081
24inositol phosphate catabolic process (GO:0071545)3.59395775
25phosphorylated carbohydrate dephosphorylation (GO:0046838)3.58270655
26inositol phosphate dephosphorylation (GO:0046855)3.58270655
27eosinophil migration (GO:0072677)3.57769724
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57743592
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57743592
30positive regulation of interferon-alpha production (GO:0032727)3.56630640
31angiotensin maturation (GO:0002003)3.56064055
32antigen processing and presentation of endogenous antigen (GO:0019883)3.54213694
33cellular extravasation (GO:0045123)3.47032933
34endocrine pancreas development (GO:0031018)3.45949913
35macrophage activation involved in immune response (GO:0002281)3.45596310
36regulation of B cell apoptotic process (GO:0002902)3.45503352
37regulation of interferon-alpha production (GO:0032647)3.43393812
38negative regulation of humoral immune response (GO:0002921)3.38354752
39neutrophil activation (GO:0042119)3.37399972
40response to type I interferon (GO:0034340)3.32610044
41detection of molecule of bacterial origin (GO:0032490)3.31516167
42granulocyte activation (GO:0036230)3.29062528
43cellular response to type I interferon (GO:0071357)3.28155992
44type I interferon signaling pathway (GO:0060337)3.28155992
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.27515967
46positive regulation of glycolytic process (GO:0045821)3.23597533
47positive regulation of mast cell activation (GO:0033005)3.23135179
48positive regulation of mast cell activation involved in immune response (GO:0033008)3.21837105
49positive regulation of mast cell degranulation (GO:0043306)3.21837105
50positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.17822250
51negative regulation of acute inflammatory response (GO:0002674)3.14737662
52insulin secretion (GO:0030073)3.13769964
53cellular ketone body metabolic process (GO:0046950)3.12296389
54lipoxygenase pathway (GO:0019372)3.11413689
55polyol catabolic process (GO:0046174)3.08764863
56reactive oxygen species biosynthetic process (GO:1903409)3.08602153
57inositol phosphate-mediated signaling (GO:0048016)3.07034070
58keratinocyte development (GO:0003334)3.06954532
59negative regulation of execution phase of apoptosis (GO:1900118)3.04840820
60lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01877968
61regulation of mast cell degranulation (GO:0043304)3.01140068
62regulation of mast cell activation (GO:0033003)3.00253353
63endosome to pigment granule transport (GO:0043485)2.99664708
64endosome to melanosome transport (GO:0035646)2.99664708
65positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.98982659
66nitric oxide biosynthetic process (GO:0006809)2.97230506
67positive regulation of histone H3-K4 methylation (GO:0051571)2.95273638
68early endosome to late endosome transport (GO:0045022)2.95109515
69hydrogen peroxide biosynthetic process (GO:0050665)2.92439503
70definitive hemopoiesis (GO:0060216)2.90154669
71ketone body metabolic process (GO:1902224)2.89761689
72positive regulation of antigen processing and presentation (GO:0002579)2.88720105
73regulation of mast cell activation involved in immune response (GO:0033006)2.87357996
74protein retention in ER lumen (GO:0006621)2.86176719
75detection of external biotic stimulus (GO:0098581)2.86077656
76imidazole-containing compound metabolic process (GO:0052803)2.85684299
77positive regulation of protein autophosphorylation (GO:0031954)2.85618418
78estrogen metabolic process (GO:0008210)2.84964579
79positive regulation of monocyte chemotaxis (GO:0090026)2.83113108
80response to host immune response (GO:0052572)2.81780503
81response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.81780503
82regulation of B cell receptor signaling pathway (GO:0050855)2.81065463
83regulation of protein glycosylation (GO:0060049)2.80098355
84macrophage activation (GO:0042116)2.80078064
85immunoglobulin mediated immune response (GO:0016064)2.79508762
86sequestering of metal ion (GO:0051238)2.79236238
87response to hydroperoxide (GO:0033194)2.77104813
88oligosaccharide catabolic process (GO:0009313)2.76802658
89regulation of mononuclear cell migration (GO:0071675)2.76627658
90nodal signaling pathway (GO:0038092)2.75470102
91xenobiotic catabolic process (GO:0042178)2.75096532
92myeloid cell activation involved in immune response (GO:0002275)2.74763149
93glycerophospholipid catabolic process (GO:0046475)2.74376673
94sequestering of extracellular ligand from receptor (GO:0035581)2.74285840
95interferon-gamma-mediated signaling pathway (GO:0060333)2.73196129
96regulation of apoptotic cell clearance (GO:2000425)2.72756018
97positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.72649166
98cell wall macromolecule catabolic process (GO:0016998)2.72601053
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71281335
100detection of other organism (GO:0098543)2.68938256
101hair cell differentiation (GO:0035315)2.67929482
102cellular response to exogenous dsRNA (GO:0071360)2.67843790
103regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.67765376
104protein prenylation (GO:0018342)2.67140299
105prenylation (GO:0097354)2.67140299
106microglial cell activation (GO:0001774)2.66749585
107superoxide anion generation (GO:0042554)2.66045268
108urate metabolic process (GO:0046415)2.65183461
109estrogen biosynthetic process (GO:0006703)2.64278661
110neutrophil mediated immunity (GO:0002446)2.64126145
111negative regulation of interleukin-8 production (GO:0032717)2.63329219
112cellular response to zinc ion (GO:0071294)2.62640778
113positive regulation of leukocyte degranulation (GO:0043302)2.62392943
114regulation of antigen processing and presentation (GO:0002577)2.60910142
115sphingomyelin metabolic process (GO:0006684)2.60672380
116negative regulation of bone resorption (GO:0045779)2.60383721
117JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.59663573
118apoptotic cell clearance (GO:0043277)2.59404456
119positive regulation of T cell migration (GO:2000406)2.58800560
120zinc ion transport (GO:0006829)2.57739768
121intestinal epithelial cell development (GO:0060576)2.56849331
122positive regulation of interferon-beta production (GO:0032728)2.56036254
123peptide hormone processing (GO:0016486)2.55626709
124regulation of T cell chemotaxis (GO:0010819)2.54375311
125positive regulation of T cell chemotaxis (GO:0010820)2.54375311
126positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54134501
127leukotriene metabolic process (GO:0006691)2.54041043
128negative regulation of interleukin-12 production (GO:0032695)2.54036163
129pinocytosis (GO:0006907)2.53426494
130lymphocyte chemotaxis (GO:0048247)2.53278278
131ER overload response (GO:0006983)2.53063542
132negative regulation of protein autophosphorylation (GO:0031953)2.52229216
133T-helper 1 type immune response (GO:0042088)2.52107607
134L-fucose catabolic process (GO:0042355)2.52053470
135fucose catabolic process (GO:0019317)2.52053470
136L-fucose metabolic process (GO:0042354)2.52053470
137negative regulation of mast cell activation (GO:0033004)2.51834017
138positive regulation of chemokine biosynthetic process (GO:0045080)2.51380809
139positive regulation of lymphocyte migration (GO:2000403)2.50890242
140positive regulation of insulin secretion (GO:0032024)2.50564414
141leukocyte aggregation (GO:0070486)2.49755186
142regulation of interleukin-12 biosynthetic process (GO:0045075)2.49298256
143UDP-N-acetylglucosamine metabolic process (GO:0006047)2.48329974
144positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.48325885
145cellular response to interferon-beta (GO:0035458)2.47787921
146protein K11-linked deubiquitination (GO:0035871)2.47606703
147positive regulation of macrophage differentiation (GO:0045651)2.46549477
148regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.46390473
149regulation of monocyte chemotaxis (GO:0090025)2.44992698
150regulation of fever generation (GO:0031620)2.44950940
151T cell migration (GO:0072678)2.44349652
152negative regulation of growth of symbiont in host (GO:0044130)2.44328574
153negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.44328574
154modulation of growth of symbiont involved in interaction with host (GO:0044144)2.44328574
155regulation of growth of symbiont in host (GO:0044126)2.44328574
156response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.44107113
157response to host (GO:0075136)2.44107113
158response to host defenses (GO:0052200)2.44107113
159regulation of interleukin-8 biosynthetic process (GO:0045414)2.43647885
160positive regulation of tumor necrosis factor production (GO:0032760)2.43290624
161regulation of myeloid leukocyte mediated immunity (GO:0002886)2.43241966
162regulation of extracellular matrix disassembly (GO:0010715)2.42408218
163nitric oxide mediated signal transduction (GO:0007263)2.40912003
164positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.39297784
165transcytosis (GO:0045056)2.39125413
166prostate gland growth (GO:0060736)2.37130939
167negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.36951467
168regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.36630638
169retinol metabolic process (GO:0042572)2.34401002
170cell wall macromolecule metabolic process (GO:0044036)2.33739632
171mesenchymal-epithelial cell signaling (GO:0060638)2.32857121
172glandular epithelial cell differentiation (GO:0002067)2.31990062
173inner ear receptor cell differentiation (GO:0060113)2.31932659
174cytochrome complex assembly (GO:0017004)2.31293265
175respiratory chain complex IV assembly (GO:0008535)2.31066788
176regulation of execution phase of apoptosis (GO:1900117)2.29916641
177negative regulation of hormone biosynthetic process (GO:0032353)2.29587567
178retrograde transport, vesicle recycling within Golgi (GO:0000301)2.29324441
179parental behavior (GO:0060746)2.28288531
180negative regulation of hormone metabolic process (GO:0032351)2.28017412
181cellular response to ethanol (GO:0071361)2.27995224
182catechol-containing compound biosynthetic process (GO:0009713)2.27150810
183catecholamine biosynthetic process (GO:0042423)2.27150810
184lactate metabolic process (GO:0006089)2.26576484
185positive regulation of peptide hormone secretion (GO:0090277)2.23941524
186intra-Golgi vesicle-mediated transport (GO:0006891)2.23128786
187hydrogen peroxide catabolic process (GO:0042744)2.20983725
188regulation of carbohydrate catabolic process (GO:0043470)2.20044163
189regulation of cellular carbohydrate catabolic process (GO:0043471)2.20044163
190regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.19854767
191positive regulation of gluconeogenesis (GO:0045722)2.18884100
192glucosamine-containing compound catabolic process (GO:1901072)2.18548602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.01792677
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.39764903
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.96210498
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.75408315
5* IRF8_27001747_Chip-Seq_BMDM_Mouse3.75135544
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.65996531
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.31956372
8GATA1_22025678_ChIP-Seq_K562_Human3.25431102
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.22792906
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22134932
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.13818067
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.96503758
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91786952
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89663011
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.77875539
16* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.74222872
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.61812445
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54053852
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40751252
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.34544275
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.31281097
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.26283419
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20365624
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.93688303
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.91707145
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88519038
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.84845499
28* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83986596
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.83201498
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82761898
31GBX2_23144817_ChIP-Seq_PC3_Human1.82378127
32ER_23166858_ChIP-Seq_MCF-7_Human1.81828962
33* TRIM28_21343339_ChIP-Seq_HEK293_Human1.77812853
34* VDR_24787735_ChIP-Seq_THP-1_Human1.75304317
35* SPI1_23547873_ChIP-Seq_NB4_Human1.74312378
36MYB_26560356_Chip-Seq_TH2_Human1.74097319
37PU_27001747_Chip-Seq_BMDM_Mouse1.72458843
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70782988
39* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65438969
40* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63268381
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57130480
42* VDR_24763502_ChIP-Seq_THP-1_Human1.57113662
43SOX2_20726797_ChIP-Seq_SW620_Human1.53398479
44P300_19829295_ChIP-Seq_ESCs_Human1.52515914
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51441091
46FUS_26573619_Chip-Seq_HEK293_Human1.51233937
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.50877885
48AHR_22903824_ChIP-Seq_MCF-7_Human1.49835655
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45409515
50* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44930743
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44441140
52* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44326534
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.44129440
54SMAD4_21799915_ChIP-Seq_A2780_Human1.41599905
55RUNX_20019798_ChIP-Seq_JUKART_Human1.41396423
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39827943
57* BRD4_25478319_ChIP-Seq_HGPS_Human1.37578810
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35911030
59SPI1_23127762_ChIP-Seq_K562_Human1.35878978
60SCL_19346495_ChIP-Seq_HPC-7_Human1.34328511
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33742788
62BCAT_22108803_ChIP-Seq_LS180_Human1.33681774
63MYB_26560356_Chip-Seq_TH1_Human1.33176121
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31448649
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30377455
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30247173
67EWS_26573619_Chip-Seq_HEK293_Human1.30132321
68GATA3_26560356_Chip-Seq_TH2_Human1.29289183
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28975820
70* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28935960
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28526040
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28399041
73CDX2_22108803_ChIP-Seq_LS180_Human1.27992024
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27883639
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27837784
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.27458910
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26744871
78* ARNT_22903824_ChIP-Seq_MCF-7_Human1.26727234
79EGR1_19032775_ChIP-ChIP_M12_Human1.25970139
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25850229
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25140267
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.24705957
83ZNF274_21170338_ChIP-Seq_K562_Hela1.24645660
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24098393
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23391559
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22640351
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22307384
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22302315
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21727150
90* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20955626
91GATA3_27048872_Chip-Seq_THYMUS_Human1.20610749
92STAT3_23295773_ChIP-Seq_U87_Human1.19836829
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19799627
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19770038
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19188109
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18330756
97AR_25329375_ChIP-Seq_VCAP_Human1.18211937
98* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17930077
99* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17577803
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.17423305
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17223429
102* CJUN_26792858_Chip-Seq_BT549_Human1.16712400
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16654006
104NANOG_19829295_ChIP-Seq_ESCs_Human1.16310912
105SOX2_19829295_ChIP-Seq_ESCs_Human1.16310912
106TAF15_26573619_Chip-Seq_HEK293_Human1.15243091
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.14200202
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.11840406
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11763238
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11763238
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11055034
112P53_22387025_ChIP-Seq_ESCs_Mouse1.10689242
113CBP_20019798_ChIP-Seq_JUKART_Human1.10654385
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10654385
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.10227862
116TCF4_23295773_ChIP-Seq_U87_Human1.08565198
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.07895706
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.07434866
119* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06691552
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.06137575
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.05615418
122MAF_26560356_Chip-Seq_TH1_Human1.04902512
123SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04743604
124STAT3_18555785_Chip-Seq_ESCs_Mouse1.04677051
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04534625
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.03325566
127IGF1R_20145208_ChIP-Seq_DFB_Human1.02674624
128ESR1_21235772_ChIP-Seq_MCF-7_Human1.02582092
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02566125
130* FOXA1_25552417_ChIP-Seq_VCAP_Human1.02343003
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02063038
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01899009
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01449087
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01139232
135GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00510336
136* FOXA1_25329375_ChIP-Seq_VCAP_Human1.00020888
137* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00020888
138LXR_22158963_ChIP-Seq_LIVER_Mouse0.99488711
139TP53_18474530_ChIP-ChIP_U2OS_Human0.99082270
140HTT_18923047_ChIP-ChIP_STHdh_Human0.98648399
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98614374
142CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97359755
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96494923
144* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96470760
145FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95258881
146GATA2_19941826_ChIP-Seq_K562_Human0.92961029
147* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86513106
148PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85404974
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83639299
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80991366
151SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80964755
152RXR_22158963_ChIP-Seq_LIVER_Mouse0.80501974
153SMRT_27268052_Chip-Seq_Bcells_Human0.80498169
154SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80340504
155SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80340504
156* WT1_19549856_ChIP-ChIP_CCG9911_Human0.79623270
157EZH2_27294783_Chip-Seq_NPCs_Mouse0.79367546
158GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79252626
159GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78569442
160SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76439016
161FOXO3_23340844_ChIP-Seq_DLD1_Human0.74562435
162SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73387609
163* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73301958
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.73009057
165GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72864800
166TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72689674
167* TP63_23658742_ChIP-Seq_EP156T_Human0.72641462
168* GATA4_25053715_ChIP-Seq_YYC3_Human0.72504833
169P63_26484246_Chip-Seq_KERATINOCYTES_Human0.72229972
170E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.71913017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.94897869
2MP0003436_decreased_susceptibility_to3.70479493
3MP0003724_increased_susceptibility_to3.59153620
4MP0001835_abnormal_antigen_presentation3.55711572
5MP0002163_abnormal_gland_morphology3.16953068
6MP0002148_abnormal_hypersensitivity_rea3.05701061
7MP0005058_abnormal_lysosome_morphology2.87946266
8MP0003303_peritoneal_inflammation2.83598541
9MP0002419_abnormal_innate_immunity2.82236487
10MP0001533_abnormal_skeleton_physiology2.81855918
11MP0002139_abnormal_hepatobiliary_system2.79875056
12MP0005387_immune_system_phenotype2.68739102
13MP0001790_abnormal_immune_system2.68739102
14MP0005000_abnormal_immune_tolerance2.66286653
15MP0009785_altered_susceptibility_to2.63614844
16MP0005174_abnormal_tail_pigmentation2.62361219
17MP0005025_abnormal_response_to2.43585276
18MP0000372_irregular_coat_pigmentation2.43382928
19MP0000569_abnormal_digit_pigmentation2.30785821
20MP0005671_abnormal_response_to2.26904371
21MP0002933_joint_inflammation2.23850797
22MP0002254_reproductive_system_inflammat2.21470317
23MP0000013_abnormal_adipose_tissue2.20558501
24MP0006082_CNS_inflammation2.13914151
25MP0008438_abnormal_cutaneous_collagen2.13801245
26MP0002877_abnormal_melanocyte_morpholog2.12192090
27MP0002452_abnormal_antigen_presenting2.11726432
28MP0010234_abnormal_vibrissa_follicle2.07707946
29MP0003183_abnormal_peptide_metabolism2.06459006
30MP0005220_abnormal_exocrine_pancreas2.01809137
31MP0003300_gastrointestinal_ulcer1.99727179
32MP0001800_abnormal_humoral_immune1.94441594
33MP0003283_abnormal_digestive_organ1.92496244
34MP0003950_abnormal_plasma_membrane1.91993325
35MP0005075_abnormal_melanosome_morpholog1.91039385
36MP0000685_abnormal_immune_system1.88439689
37MP0002723_abnormal_immune_serum1.88406262
38MP0002998_abnormal_bone_remodeling1.85738677
39MP0001819_abnormal_immune_cell1.80634958
40MP0002420_abnormal_adaptive_immunity1.79099208
41MP0000015_abnormal_ear_pigmentation1.77821508
42MP0001845_abnormal_inflammatory_respons1.71833297
43MP0002166_altered_tumor_susceptibility1.71709352
44MP0005464_abnormal_platelet_physiology1.69998831
45MP0001756_abnormal_urination1.63371415
46MP0005390_skeleton_phenotype1.60675518
47MP0002006_tumorigenesis1.60252385
48MP0010329_abnormal_lipoprotein_level1.58331944
49MP0002405_respiratory_system_inflammati1.58055214
50MP0010155_abnormal_intestine_physiology1.54292316
51MP0004947_skin_inflammation1.53003547
52MP0003045_fibrosis1.49595899
53MP0000516_abnormal_urinary_system1.49526599
54MP0005367_renal/urinary_system_phenotyp1.49526599
55MP0003191_abnormal_cellular_cholesterol1.49265104
56MP0003795_abnormal_bone_structure1.48848346
57MP0005332_abnormal_amino_acid1.47995964
58MP0000343_altered_response_to1.47826837
59MP0002928_abnormal_bile_duct1.44203229
60MP0008469_abnormal_protein_level1.44130343
61MP0006054_spinal_hemorrhage1.42748411
62MP0000003_abnormal_adipose_tissue1.42402212
63MP0005646_abnormal_pituitary_gland1.41491963
64MP0003172_abnormal_lysosome_physiology1.41138600
65MP0004019_abnormal_vitamin_homeostasis1.40036656
66MP0004510_myositis1.38846652
67MP0009333_abnormal_splenocyte_physiolog1.38383017
68MP0009764_decreased_sensitivity_to1.37119995
69MP0003252_abnormal_bile_duct1.37008455
70MP0005379_endocrine/exocrine_gland_phen1.33629835
71MP0003866_abnormal_defecation1.32662633
72MP0001542_abnormal_bone_strength1.31834151
73MP0002909_abnormal_adrenal_gland1.31003125
74MP0009840_abnormal_foam_cell1.29452622
75MP0003448_altered_tumor_morphology1.29355055
76MP0009780_abnormal_chondrocyte_physiolo1.25926747
77MP0002693_abnormal_pancreas_physiology1.25723297
78MP0003075_altered_response_to1.25373693
79MP0000716_abnormal_immune_system1.23293473
80MP0005310_abnormal_salivary_gland1.23236544
81MP0003566_abnormal_cell_adhesion1.21600090
82MP0004782_abnormal_surfactant_physiolog1.21448307
83MP0005171_absent_coat_pigmentation1.21194350
84MP0005408_hypopigmentation1.20904111
85MP0001853_heart_inflammation1.20881305
86MP0005084_abnormal_gallbladder_morpholo1.19991444
87MP0002138_abnormal_hepatobiliary_system1.19154900
88MP0010678_abnormal_skin_adnexa1.18855605
89MP0010352_gastrointestinal_tract_polyps1.16262656
90MP0002078_abnormal_glucose_homeostasis1.15779718
91MP0002896_abnormal_bone_mineralization1.15394599
92MP0002971_abnormal_brown_adipose1.15331603
93MP0004484_altered_response_of1.13046783
94MP0004808_abnormal_hematopoietic_stem1.12488421
95MP0008004_abnormal_stomach_pH1.10695208
96MP0005164_abnormal_response_to1.09496433
97MP0000465_gastrointestinal_hemorrhage1.07323868
98MP0008875_abnormal_xenobiotic_pharmacok1.06978611
99MP0003195_calcinosis1.06768278
100MP0000858_altered_metastatic_potential1.05684399
101MP0005365_abnormal_bile_salt1.05588267
102MP0001663_abnormal_digestive_system1.05543830
103MP0010386_abnormal_urinary_bladder1.03857324
104MP0000427_abnormal_hair_cycle1.03726060
105MP0002398_abnormal_bone_marrow1.02116666
106MP0005166_decreased_susceptibility_to1.01068376
107MP0006072_abnormal_retinal_apoptosis0.95035396
108MP0001764_abnormal_homeostasis0.94517356
109MP0002429_abnormal_blood_cell0.93829473
110MP0005636_abnormal_mineral_homeostasis0.93522454
111MP0000371_diluted_coat_color0.93243963
112MP0009763_increased_sensitivity_to0.92604317
113MP0004134_abnormal_chest_morphology0.92500803
114MP0005448_abnormal_energy_balance0.91803537
115MP0005645_abnormal_hypothalamus_physiol0.91700029
116MP0002876_abnormal_thyroid_physiology0.91588352
117MP0001851_eye_inflammation0.90790244
118MP0002115_abnormal_skeleton_extremities0.90163366
119MP0002118_abnormal_lipid_homeostasis0.90069593
120MP0005076_abnormal_cell_differentiation0.88201761
121MP0001765_abnormal_ion_homeostasis0.87869732
122MP0003953_abnormal_hormone_level0.87683507
123MP0005275_abnormal_skin_tensile0.87055726
124MP0000639_abnormal_adrenal_gland0.86807041
125MP0005389_reproductive_system_phenotype0.86236101
126MP0001501_abnormal_sleep_pattern0.86069315
127MP0005319_abnormal_enzyme/_coenzyme0.84461842
128MP0001873_stomach_inflammation0.84080245
129MP0000538_abnormal_urinary_bladder0.83862370
130MP0000163_abnormal_cartilage_morphology0.83402429
131MP0002113_abnormal_skeleton_development0.83051361
132MP0005503_abnormal_tendon_morphology0.82714671
133MP0002277_abnormal_respiratory_mucosa0.82275264
134MP0008961_abnormal_basal_metabolism0.81773173
135MP0000689_abnormal_spleen_morphology0.81509572
136MP0005381_digestive/alimentary_phenotyp0.81205248
137MP0002938_white_spotting0.81020385
138MP0009115_abnormal_fat_cell0.80939164
139MP0005085_abnormal_gallbladder_physiolo0.80218639
140MP0002168_other_aberrant_phenotype0.80198862
141MP0000249_abnormal_blood_vessel0.79332953
142MP0002009_preneoplasia0.78948471
143MP0002295_abnormal_pulmonary_circulatio0.78882196
144MP0003786_premature_aging0.78767041
145MP0000383_abnormal_hair_follicle0.77922997
146MP0005551_abnormal_eye_electrophysiolog0.77434567
147MP0003787_abnormal_imprinting0.76815110
148MP0003690_abnormal_glial_cell0.75656475
149MP0008057_abnormal_DNA_replication0.75222191
150MP0005647_abnormal_sex_gland0.75097935
151MP0003279_aneurysm0.74777643
152MP0002160_abnormal_reproductive_system0.74582171
153MP0001545_abnormal_hematopoietic_system0.74457872
154MP0005397_hematopoietic_system_phenotyp0.74457872
155MP0004043_abnormal_pH_regulation0.73654308
156MP0002722_abnormal_immune_system0.73339307
157MP0003186_abnormal_redox_activity0.72920882
158MP0002060_abnormal_skin_morphology0.72744208
159MP0009384_cardiac_valve_regurgitation0.72105251
160MP0005165_increased_susceptibility_to0.71442208
161MP0002396_abnormal_hematopoietic_system0.71122091
162MP0008877_abnormal_DNA_methylation0.70378252
163MP0003763_abnormal_thymus_physiology0.70070667
164MP0005535_abnormal_body_temperature0.68493534
165MP0001944_abnormal_pancreas_morphology0.66211072
166MP0009643_abnormal_urine_homeostasis0.66023874
167MP0005023_abnormal_wound_healing0.65469234
168MP0003656_abnormal_erythrocyte_physiolo0.64469717
169MP0004264_abnormal_extraembryonic_tissu0.63256390
170MP0002136_abnormal_kidney_physiology0.62469865
171MP0003828_pulmonary_edema0.61449772
172MP0000604_amyloidosis0.60904124

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)5.55251861
2Irregular epiphyses (HP:0010582)4.52932656
3Eczematoid dermatitis (HP:0000976)4.51224773
4Systemic lupus erythematosus (HP:0002725)4.41150606
5Recurrent abscess formation (HP:0002722)4.37966829
6Recurrent bacterial skin infections (HP:0005406)4.02861913
7Hyperglycemia (HP:0003074)3.92283801
8Cupped ribs (HP:0000887)3.85207465
9Large for gestational age (HP:0001520)3.79867641
10Vacuolated lymphocytes (HP:0001922)3.68960260
11Increased CSF protein (HP:0002922)3.68464588
12Hypothermia (HP:0002045)3.54405654
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.50172128
14Albinism (HP:0001022)3.46126500
15Small epiphyses (HP:0010585)3.43614264
16Vitreoretinal degeneration (HP:0000655)3.36969471
17Flat acetabular roof (HP:0003180)3.34963522
18Congenital sensorineural hearing impairment (HP:0008527)3.32135705
19Recurrent gram-negative bacterial infections (HP:0005420)3.30918033
20Abnormal tarsal ossification (HP:0008369)3.30889046
21Flat capital femoral epiphysis (HP:0003370)3.22319762
22Vascular calcification (HP:0004934)3.22295176
23Glomerulonephritis (HP:0000099)3.17932879
24Hypoplastic ischia (HP:0003175)3.17789429
25Metaphyseal cupping (HP:0003021)3.15433975
26Dysostosis multiplex (HP:0000943)3.13526602
27Cardiovascular calcification (HP:0011915)3.12711060
28Cervical subluxation (HP:0003308)3.12549623
29Episodic fever (HP:0001954)3.04087280
30Hypoglycemic coma (HP:0001325)2.98054216
31Abnormal foot bone ossification (HP:0010675)2.95280145
32Hematochezia (HP:0002573)2.94391089
33Hyperinsulinemic hypoglycemia (HP:0000825)2.92287026
34Arthropathy (HP:0003040)2.91186865
35Insulin-resistant diabetes mellitus (HP:0000831)2.89902621
36Cutaneous melanoma (HP:0012056)2.86030261
37Abnormality of the vertebral endplates (HP:0005106)2.85824578
38Beaking of vertebral bodies (HP:0004568)2.85824474
39Abnormality of the ischium (HP:0003174)2.81541832
40Delayed epiphyseal ossification (HP:0002663)2.80426700
41Myositis (HP:0100614)2.80031837
42Metaphyseal dysplasia (HP:0100255)2.74435501
43Urinary glycosaminoglycan excretion (HP:0003541)2.74373375
44Mucopolysacchariduria (HP:0008155)2.74373375
45Conjunctival hamartoma (HP:0100780)2.74099389
46Ketoacidosis (HP:0001993)2.71466216
47Orchitis (HP:0100796)2.70251650
48Abnormality of macrophages (HP:0004311)2.65325136
49Periodontitis (HP:0000704)2.65059417
50Metaphyseal irregularity (HP:0003025)2.62340263
51Osteoarthritis (HP:0002758)2.61652444
52Elevated erythrocyte sedimentation rate (HP:0003565)2.61170915
53Genu varum (HP:0002970)2.59440933
54Abnormal pancreas size (HP:0012094)2.56684806
55Gingivitis (HP:0000230)2.55503233
56Flattened epiphyses (HP:0003071)2.54609995
57Ovoid vertebral bodies (HP:0003300)2.54324015
58Retrobulbar optic neuritis (HP:0100654)2.53307472
59Optic neuritis (HP:0100653)2.53307472
60Irregular vertebral endplates (HP:0003301)2.52927631
61Chronic obstructive pulmonary disease (HP:0006510)2.52821594
62Obstructive lung disease (HP:0006536)2.52821594
63Hypoglycemic seizures (HP:0002173)2.52643364
64Abnormality of the renal cortex (HP:0011035)2.50750995
65Thoracolumbar scoliosis (HP:0002944)2.50126800
66Protuberant abdomen (HP:0001538)2.48643305
67Abnormality of vitamin B metabolism (HP:0004340)2.48207026
68Postural tremor (HP:0002174)2.47794019
69Hamartoma of the eye (HP:0010568)2.47439731
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.46654860
71Abnormality of polysaccharide metabolism (HP:0011012)2.46654860
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.46654860
73Abnormality of urine glucose concentration (HP:0011016)2.46439626
74Glycosuria (HP:0003076)2.46439626
75Recurrent fungal infections (HP:0002841)2.45720037
76Recurrent skin infections (HP:0001581)2.45263432
77Abnormality of the lumbar spine (HP:0100712)2.44844381
78Hypokinesia (HP:0002375)2.44691910
79Abnormality of complement system (HP:0005339)2.41936809
80Loss of speech (HP:0002371)2.40831888
81Enlarged epiphyses (HP:0010580)2.40253518
82Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.38840626
83Abnormality of femoral epiphyses (HP:0006499)2.38840626
84Autoimmune thrombocytopenia (HP:0001973)2.38680589
85Platyspondyly (HP:0000926)2.35153075
86Tongue fasciculations (HP:0001308)2.31952490
87Prostate neoplasm (HP:0100787)2.28027277
88Aplasia/Hypoplasia of the fovea (HP:0008060)2.27221357
89Hypoplasia of the fovea (HP:0007750)2.27221357
90Mediastinal lymphadenopathy (HP:0100721)2.26263816
91Intestinal atresia (HP:0011100)2.25592062
92Abnormality of liposaccharide metabolism (HP:0010968)2.24813091
93Abnormality of glycosphingolipid metabolism (HP:0004343)2.24813091
94Abnormality of glycolipid metabolism (HP:0010969)2.24813091
95Recurrent viral infections (HP:0004429)2.23293611
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.21920717
97Neonatal short-limb short stature (HP:0008921)2.21678893
98Renal cortical cysts (HP:0000803)2.21569393
99Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.20599158
100Hemiparesis (HP:0001269)2.20454671
101Exocrine pancreatic insufficiency (HP:0001738)2.19768222
102Coxa vara (HP:0002812)2.18371703
103Abnormality of the epiphysis of the femoral head (HP:0010574)2.18006813
104Mild short stature (HP:0003502)2.17163010
105Abnormality of the femoral head (HP:0003368)2.16642740
106Orthostatic hypotension (HP:0001278)2.16605746
107Absent frontal sinuses (HP:0002688)2.15341415
108Widely spaced teeth (HP:0000687)2.15154791
109Abnormal vertebral ossification (HP:0100569)2.14573772
110Polydipsia (HP:0001959)2.13437706
111Abnormal drinking behavior (HP:0030082)2.13437706
112Disproportionate short-trunk short stature (HP:0003521)2.12924600
113Stomatitis (HP:0010280)2.12873887
114Increased cerebral lipofuscin (HP:0011813)2.12578849
115Progressive neurologic deterioration (HP:0002344)2.12327628
116Spondylolisthesis (HP:0003302)2.12313150
117Prolonged bleeding time (HP:0003010)2.09725046
118Bone cyst (HP:0012062)2.09160850
119Vertebral compression fractures (HP:0002953)2.07854588
120Muscle fibrillation (HP:0010546)2.05803412
121Hyperventilation (HP:0002883)2.05633528
122Tetraparesis (HP:0002273)2.05042226
123J-shaped sella turcica (HP:0002680)2.03543347
124Testicular neoplasm (HP:0010788)2.03173012
125Pulmonary infiltrates (HP:0002113)2.02005066
126Abnormal rod and cone electroretinograms (HP:0008323)2.02003658
127Abnormality of carpal bone ossification (HP:0006257)2.01486121
128Spinal cord compression (HP:0002176)2.01306053
129Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00947462
130Vasculitis (HP:0002633)2.00347051
131Gastrointestinal infarctions (HP:0005244)1.99428668
132Sensory axonal neuropathy (HP:0003390)1.99399612
133Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.99154171
134Joint stiffness (HP:0001387)1.99081159
135Patchy hypopigmentation of hair (HP:0011365)1.97952344
136Hypoplasia of the odontoid process (HP:0003311)1.96431905
137Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.96323687
138Vertebral hypoplasia (HP:0008417)1.96323687
139Peritonitis (HP:0002586)1.96147657
140Gaze-evoked nystagmus (HP:0000640)1.95954435
141Thoracic kyphosis (HP:0002942)1.94836214
142Thick nail (HP:0001805)1.94151274
143Sex reversal (HP:0012245)1.93840331
144Abnormal sex determination (HP:0012244)1.93840331
145Petechiae (HP:0000967)1.93775911
146Abnormality of the frontal sinuses (HP:0002687)1.93235553
147Attenuation of retinal blood vessels (HP:0007843)1.92057255
148White forelock (HP:0002211)1.92003004
149Nephritis (HP:0000123)1.91361443
150Ketosis (HP:0001946)1.90712173
151Proximal tubulopathy (HP:0000114)1.90379201
152Congenital stationary night blindness (HP:0007642)1.89464327
153Abnormality of vitamin metabolism (HP:0100508)1.89056468
154Tubular atrophy (HP:0000092)1.89035738
155Osteolytic defects of the hand bones (HP:0009699)1.89021488
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.89021488
157Abnormality of the common coagulation pathway (HP:0010990)1.88779207
158Pustule (HP:0200039)1.88231988
159Complement deficiency (HP:0004431)1.87839249
160Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87344272
161Urethral obstruction (HP:0000796)1.86755768
162Late onset (HP:0003584)1.85969584
163Abnormality of the pancreatic islet cells (HP:0006476)1.85309256
164Abnormality of endocrine pancreas physiology (HP:0012093)1.85309256
165Furrowed tongue (HP:0000221)1.85254170
166Follicular hyperkeratosis (HP:0007502)1.84978522
167Double outlet right ventricle (HP:0001719)1.84805608
168Congenital malformation of the right heart (HP:0011723)1.84805608
169Hypergonadotropic hypogonadism (HP:0000815)1.84714599
170Hypoalbuminemia (HP:0003073)1.82675744
171Abnormal albumin level (HP:0012116)1.82675744
172Gingival bleeding (HP:0000225)1.82184363
173Mesangial abnormality (HP:0001966)1.82030696
174Enlarged penis (HP:0000040)1.78796672
175Aplasia/Hypoplasia of the macula (HP:0008059)1.77260027
176Acute myeloid leukemia (HP:0004808)1.77166660
177Neoplasm of the tracheobronchial system (HP:0100552)1.75097527
178Abnormality of renal excretion (HP:0011036)1.73361446
179Thyroiditis (HP:0100646)1.71819487
180Progressive macrocephaly (HP:0004481)1.71303413
181Mitral stenosis (HP:0001718)1.71025552
182Type I diabetes mellitus (HP:0100651)1.70636703
183Cardiomegaly (HP:0001640)1.70105065
184Constricted visual fields (HP:0001133)1.68899860
185Abnormal biliary tract morphology (HP:0012440)1.66815284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.05129952
2IRAK33.30615272
3MAP3K143.25120957
4IRAK43.16895171
5BLK2.68968476
6MAP4K22.51212834
7TRIM282.49692028
8ERN12.43752786
9FER2.35068900
10TYK22.33316455
11MST1R2.32628948
12MST42.26940630
13TBK12.22149874
14TXK2.18966032
15FGFR22.11404257
16GRK12.11253822
17PIM22.08448617
18JAK12.06975624
19INSRR2.03968225
20MAP3K31.93496044
21DAPK21.92601922
22TEC1.88990963
23STK241.88814586
24ACVR1B1.84067661
25MAP4K11.80611217
26STK391.73902416
27PAK31.71716403
28IKBKE1.70712905
29ADRBK21.68276639
30PDK21.67901373
31EPHB11.66284953
32EPHA31.62002138
33JAK31.59627198
34AKT31.59047073
35PNCK1.53985728
36RIPK41.52434585
37LMTK21.50928332
38IRAK11.49373506
39NUAK11.46797461
40WNK31.44632912
41TGFBR21.43526954
42CSK1.43103892
43IKBKB1.43074431
44KIT1.42224737
45ZAP701.35090710
46PHKG11.30473640
47PHKG21.30473640
48TRPM71.30231945
49FRK1.22820078
50PIK3CG1.19789760
51ITK1.18842391
52FGFR31.18371570
53BTK1.18348001
54GRK71.13867318
55MKNK21.11719350
56TAOK11.11185563
57HIPK21.07336597
58STK38L1.07280632
59CLK11.05715428
60RIPK11.04106186
61MAP2K61.04000755
62TNIK1.03356004
63JAK20.98362943
64NEK90.97412695
65BMPR1B0.97330781
66CHUK0.97275378
67PRKG20.95085290
68STK100.92180607
69OXSR10.91702860
70NLK0.91135847
71LYN0.88642854
72TNK20.87876996
73PLK20.87848861
74PBK0.87478021
75STK30.87164700
76PTK2B0.85294049
77BMPR20.85031005
78FGFR40.84778674
79SYK0.84262582
80PIM10.83915791
81LCK0.83161524
82MAP3K120.81784698
83ZAK0.81525959
84EIF2AK20.80530556
85HCK0.79044211
86FLT30.78933186
87MYLK0.76783929
88WNK40.75899549
89DDR20.75695680
90BRSK20.75654407
91MAP3K20.74781623
92CAMK2D0.74220009
93CAMK1D0.73145499
94ADRBK10.72493131
95MATK0.69850463
96PRKCI0.68653485
97MAPK150.67565149
98PRKAA20.67052707
99RPS6KA40.67051274
100PIK3CA0.65690871
101PRKD20.65624267
102SCYL20.63830984
103IRAK20.60545503
104ERBB30.60490165
105MARK30.60052236
106MET0.57988869
107RPS6KA60.57975074
108EIF2AK30.57569351
109GRK60.56886844
110MAP2K30.56736325
111RPS6KL10.56395296
112RPS6KC10.56395296
113MAP3K10.56036612
114MAP3K130.54589733
115CSF1R0.53142323
116PTK60.52483533
117MKNK10.52013153
118FES0.50498825
119CDK60.49436377
120IGF1R0.47390466
121PRKAA10.46883582
122ABL20.46743892
123STK110.46120934
124CAMKK20.45643343
125PRKCQ0.44746201
126MAP2K10.43165774
127GSK3A0.42100240
128PRKCD0.41621151
129ROCK10.39812321
130MAP3K50.38476015
131YES10.37963748
132EGFR0.37597700
133DYRK1B0.35933939
134PINK10.35931530
135PRKD10.34959329
136ABL10.34873320
137CDK90.34794795
138PRKCE0.34372510
139MAPKAPK20.33854258
140RPS6KA20.33301518
141MAP3K40.30857183
142NME20.30718788
143MUSK0.30618342
144NME10.30347424
145CAMK1G0.29993903
146STK40.29721736
147BMX0.28943673
148DMPK0.28311363
149RPS6KA50.28270422
150CDK30.26904613
151PRKACB0.23217349

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.39617122
2Other glycan degradation_Homo sapiens_hsa005113.07515183
3Leishmaniasis_Homo sapiens_hsa051402.68089446
4Protein export_Homo sapiens_hsa030602.66015140
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.34877628
6Pertussis_Homo sapiens_hsa051332.27818388
7Legionellosis_Homo sapiens_hsa051342.20457435
8Butanoate metabolism_Homo sapiens_hsa006502.13463816
9Lysosome_Homo sapiens_hsa041422.11171586
10Asthma_Homo sapiens_hsa053102.04630855
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04400211
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.01267023
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99878502
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.99143116
15Osteoclast differentiation_Homo sapiens_hsa043801.96664412
16Malaria_Homo sapiens_hsa051441.93920361
17Dorso-ventral axis formation_Homo sapiens_hsa043201.86641828
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83932470
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80798821
20Ether lipid metabolism_Homo sapiens_hsa005651.77031372
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.76450845
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75105732
23Hematopoietic cell lineage_Homo sapiens_hsa046401.74753286
24Graft-versus-host disease_Homo sapiens_hsa053321.74361739
25Phagosome_Homo sapiens_hsa041451.71370641
26Sulfur metabolism_Homo sapiens_hsa009201.69976172
27Measles_Homo sapiens_hsa051621.66454103
28Rheumatoid arthritis_Homo sapiens_hsa053231.63157521
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62504614
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60738618
31Tuberculosis_Homo sapiens_hsa051521.59542181
32Type I diabetes mellitus_Homo sapiens_hsa049401.59125800
33Tryptophan metabolism_Homo sapiens_hsa003801.54632939
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52699266
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.49028375
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48163926
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.47200409
38Antigen processing and presentation_Homo sapiens_hsa046121.46659824
39Nitrogen metabolism_Homo sapiens_hsa009101.43059557
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42566935
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42116990
42Allograft rejection_Homo sapiens_hsa053301.41566001
43Collecting duct acid secretion_Homo sapiens_hsa049661.38762995
44Toxoplasmosis_Homo sapiens_hsa051451.37694165
45Insulin secretion_Homo sapiens_hsa049111.34866438
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33944460
47Sphingolipid metabolism_Homo sapiens_hsa006001.31395756
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31020841
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28990835
50Influenza A_Homo sapiens_hsa051641.28194106
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27076912
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26923994
53TNF signaling pathway_Homo sapiens_hsa046681.26484925
54Chemical carcinogenesis_Homo sapiens_hsa052041.24440070
55Peroxisome_Homo sapiens_hsa041461.19917374
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.18089168
57Complement and coagulation cascades_Homo sapiens_hsa046101.16393115
58Autoimmune thyroid disease_Homo sapiens_hsa053201.13901089
59ECM-receptor interaction_Homo sapiens_hsa045121.13506765
60Fatty acid elongation_Homo sapiens_hsa000621.12087756
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11918471
62Chemokine signaling pathway_Homo sapiens_hsa040621.10067610
63Salmonella infection_Homo sapiens_hsa051321.08956824
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07705094
65Herpes simplex infection_Homo sapiens_hsa051681.07029219
66Protein digestion and absorption_Homo sapiens_hsa049741.05246185
67Phototransduction_Homo sapiens_hsa047441.00993725
68Retinol metabolism_Homo sapiens_hsa008300.99209961
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96963569
70Hepatitis C_Homo sapiens_hsa051600.96554286
71Renin-angiotensin system_Homo sapiens_hsa046140.95130147
72Apoptosis_Homo sapiens_hsa042100.92952058
73B cell receptor signaling pathway_Homo sapiens_hsa046620.92528436
74Glutathione metabolism_Homo sapiens_hsa004800.92095686
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91947816
76Vitamin B6 metabolism_Homo sapiens_hsa007500.91123836
77Selenocompound metabolism_Homo sapiens_hsa004500.90912541
78Galactose metabolism_Homo sapiens_hsa000520.88150331
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87961862
80Hepatitis B_Homo sapiens_hsa051610.87815235
81Arachidonic acid metabolism_Homo sapiens_hsa005900.87660480
82Circadian rhythm_Homo sapiens_hsa047100.86516547
83Fatty acid degradation_Homo sapiens_hsa000710.86450665
84Pancreatic secretion_Homo sapiens_hsa049720.86291552
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86254899
86Propanoate metabolism_Homo sapiens_hsa006400.85598794
87Primary immunodeficiency_Homo sapiens_hsa053400.84688481
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84456151
89Vibrio cholerae infection_Homo sapiens_hsa051100.83704953
90Folate biosynthesis_Homo sapiens_hsa007900.83274034
91Amoebiasis_Homo sapiens_hsa051460.82906643
92N-Glycan biosynthesis_Homo sapiens_hsa005100.81010156
93Caffeine metabolism_Homo sapiens_hsa002320.79690120
94Starch and sucrose metabolism_Homo sapiens_hsa005000.79684415
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74987778
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74986854
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72289370
98Type II diabetes mellitus_Homo sapiens_hsa049300.70873060
99Renin secretion_Homo sapiens_hsa049240.68804168
100Mineral absorption_Homo sapiens_hsa049780.68333777
101Arginine biosynthesis_Homo sapiens_hsa002200.67834618
102Regulation of autophagy_Homo sapiens_hsa041400.67587517
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66884350
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.65423036
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64881031
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62249735
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60301404
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59808366
109T cell receptor signaling pathway_Homo sapiens_hsa046600.58573339
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.57764965
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57227254
112Viral myocarditis_Homo sapiens_hsa054160.57102864
113Prion diseases_Homo sapiens_hsa050200.55825252
114Inositol phosphate metabolism_Homo sapiens_hsa005620.55794320
115Platelet activation_Homo sapiens_hsa046110.55451259
116Prolactin signaling pathway_Homo sapiens_hsa049170.55254174
117Insulin resistance_Homo sapiens_hsa049310.54796242
118Shigellosis_Homo sapiens_hsa051310.53984394
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53866543
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.53639506
121ABC transporters_Homo sapiens_hsa020100.53436160
122Fatty acid metabolism_Homo sapiens_hsa012120.53094319
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52046132
124Histidine metabolism_Homo sapiens_hsa003400.50423287
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.48863296
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48637018
127Acute myeloid leukemia_Homo sapiens_hsa052210.47543629
128Metabolic pathways_Homo sapiens_hsa011000.47380407
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47050373
130Oxidative phosphorylation_Homo sapiens_hsa001900.44603720
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43601350
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.41558108
133African trypanosomiasis_Homo sapiens_hsa051430.41493701
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41026738
135Focal adhesion_Homo sapiens_hsa045100.40975977
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40730175
137Chronic myeloid leukemia_Homo sapiens_hsa052200.39913274
138Pancreatic cancer_Homo sapiens_hsa052120.39731887
139Thyroid hormone synthesis_Homo sapiens_hsa049180.39501613
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39303448
141Glucagon signaling pathway_Homo sapiens_hsa049220.36891835
142Salivary secretion_Homo sapiens_hsa049700.36696886
143Melanoma_Homo sapiens_hsa052180.34503466
144TGF-beta signaling pathway_Homo sapiens_hsa043500.34197750
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33871170
146Vitamin digestion and absorption_Homo sapiens_hsa049770.32967912
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32037037
148Prostate cancer_Homo sapiens_hsa052150.31136999
149Linoleic acid metabolism_Homo sapiens_hsa005910.30037350
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.30018301
151Ovarian steroidogenesis_Homo sapiens_hsa049130.27779656
152Small cell lung cancer_Homo sapiens_hsa052220.25403671

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