FAM3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytokine-like protein. The expression of this gene may be regulated by peroxisome proliferator-activated receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.14313635
2Golgi transport vesicle coating (GO:0048200)6.14313635
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.96434825
4protein retention in ER lumen (GO:0006621)4.68629680
5regulation of cholesterol homeostasis (GO:2000188)4.13184461
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.07469127
7L-phenylalanine metabolic process (GO:0006558)4.07469127
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.02746024
9L-phenylalanine catabolic process (GO:0006559)4.02746024
10alpha-linolenic acid metabolic process (GO:0036109)4.02662037
11fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.88681253
12activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.70364239
13tricarboxylic acid metabolic process (GO:0072350)3.66139589
14negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.61439655
15valine metabolic process (GO:0006573)3.57963469
16sulfur amino acid catabolic process (GO:0000098)3.54079397
17positive regulation of nuclease activity (GO:0032075)3.48809826
18COPII vesicle coating (GO:0048208)3.42347856
19pyrimidine nucleoside salvage (GO:0043097)3.36680300
20pyrimidine-containing compound salvage (GO:0008655)3.36680300
21peptide catabolic process (GO:0043171)3.35681352
22retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.32151439
23GDP-mannose metabolic process (GO:0019673)3.31313243
24macroautophagy (GO:0016236)3.27250092
25endoplasmic reticulum unfolded protein response (GO:0030968)3.26706829
26signal peptide processing (GO:0006465)3.23803060
27regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.19949884
284-hydroxyproline metabolic process (GO:0019471)3.19749296
29positive regulation of triglyceride biosynthetic process (GO:0010867)3.19424353
30fatty acid beta-oxidation (GO:0006635)3.15194634
31cellular response to unfolded protein (GO:0034620)3.14056058
32regulation of triglyceride catabolic process (GO:0010896)3.10611337
33opioid receptor signaling pathway (GO:0038003)3.09126591
34regulation of nuclease activity (GO:0032069)3.08115834
35regulation of interferon-beta biosynthetic process (GO:0045357)3.07887852
36L-alpha-amino acid transmembrane transport (GO:1902475)3.07580698
37positive regulation of lipoprotein lipase activity (GO:0051006)3.01733134
38positive regulation of triglyceride lipase activity (GO:0061365)3.01733134
39ER-nucleus signaling pathway (GO:0006984)3.00837740
402-oxoglutarate metabolic process (GO:0006103)2.99193355
41apoptotic cell clearance (GO:0043277)2.95904704
42cellular response to topologically incorrect protein (GO:0035967)2.95875903
43oxaloacetate metabolic process (GO:0006107)2.95189133
44drug catabolic process (GO:0042737)2.93692476
45lysine metabolic process (GO:0006553)2.93421123
46lysine catabolic process (GO:0006554)2.93421123
47fatty acid oxidation (GO:0019395)2.92022713
48response to pheromone (GO:0019236)2.87873789
49positive regulation of fatty acid biosynthetic process (GO:0045723)2.87021394
50regulation of hydrogen peroxide metabolic process (GO:0010310)2.86229049
51acylglycerol homeostasis (GO:0055090)2.85939056
52triglyceride homeostasis (GO:0070328)2.85939056
53aromatic amino acid family catabolic process (GO:0009074)2.84259412
54sequestering of metal ion (GO:0051238)2.83866004
55lipid oxidation (GO:0034440)2.82868873
56protein carboxylation (GO:0018214)2.82609327
57peptidyl-glutamic acid carboxylation (GO:0017187)2.82609327
58fatty acid catabolic process (GO:0009062)2.81889281
59flavonoid metabolic process (GO:0009812)2.80763060
60glyoxylate metabolic process (GO:0046487)2.79979249
61sulfation (GO:0051923)2.79091668
62positive regulation of fatty acid transport (GO:2000193)2.76469811
63positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.75397289
64hormone catabolic process (GO:0042447)2.75388867
65protein maturation by protein folding (GO:0022417)2.73576105
66endocrine pancreas development (GO:0031018)2.72889483
67nucleoside salvage (GO:0043174)2.70897993
68positive regulation of triglyceride metabolic process (GO:0090208)2.68943281
69response to misfolded protein (GO:0051788)2.68189503
70negative regulation of cAMP-mediated signaling (GO:0043951)2.68116189
71positive regulation of defense response to virus by host (GO:0002230)2.67116549
72regulation of triglyceride metabolic process (GO:0090207)2.66616170
73positive regulation of icosanoid secretion (GO:0032305)2.66471769
74peptide hormone processing (GO:0016486)2.65672863
75transcytosis (GO:0045056)2.65412845
76ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.64607156
77auditory receptor cell stereocilium organization (GO:0060088)2.64095305
78positive regulation of protein kinase C signaling (GO:0090037)2.63466404
79glandular epithelial cell development (GO:0002068)2.61654953
80vesicle coating (GO:0006901)2.61019416
81xenobiotic catabolic process (GO:0042178)2.60806017
82detection of molecule of bacterial origin (GO:0032490)2.60064865
83negative regulation of fibrinolysis (GO:0051918)2.58308897
84monocarboxylic acid catabolic process (GO:0072329)2.56983161
85autophagic vacuole fusion (GO:0000046)2.56519252
86exocrine pancreas development (GO:0031017)2.56396724
87cellular response to exogenous dsRNA (GO:0071360)2.55742359
88regulation of cholesterol storage (GO:0010885)2.54304901
89ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.53725980
90toxin metabolic process (GO:0009404)2.53310869
91regulation of cholesterol biosynthetic process (GO:0045540)2.51576626
92response to endoplasmic reticulum stress (GO:0034976)2.50915642
93uronic acid metabolic process (GO:0006063)2.50598542
94glucuronate metabolic process (GO:0019585)2.50598542
95drug transmembrane transport (GO:0006855)2.50049121
96negative regulation of glycoprotein biosynthetic process (GO:0010561)2.49462145
97branched-chain amino acid metabolic process (GO:0009081)2.48694270
98drug metabolic process (GO:0017144)2.48388035
99cellular ketone body metabolic process (GO:0046950)2.48252801
100cellular biogenic amine catabolic process (GO:0042402)2.47776443
101amine catabolic process (GO:0009310)2.47776443
102negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.47259401
103regulation of type B pancreatic cell apoptotic process (GO:2000674)2.47004896
104intestinal cholesterol absorption (GO:0030299)2.46633748
105lytic vacuole organization (GO:0080171)2.46046428
106lysosome organization (GO:0007040)2.46046428
107negative regulation of digestive system process (GO:0060457)2.45383086
108negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.43817960
109mannosylation (GO:0097502)2.42105368
110fusion of sperm to egg plasma membrane (GO:0007342)2.41935877
111NADH metabolic process (GO:0006734)2.41722942
112indolalkylamine catabolic process (GO:0046218)2.41368534
113tryptophan catabolic process (GO:0006569)2.41368534
114indole-containing compound catabolic process (GO:0042436)2.41368534
115cofactor catabolic process (GO:0051187)2.40687958
116antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.40089929
117antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.40089929
118arginine catabolic process (GO:0006527)2.39837102
119protein N-linked glycosylation via asparagine (GO:0018279)2.39684573
120oxidative demethylation (GO:0070989)2.38816868
121peptidyl-asparagine modification (GO:0018196)2.38790120
122tyrosine metabolic process (GO:0006570)2.38431331
123cysteine metabolic process (GO:0006534)2.38033159
124negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.37238467
125glutathione biosynthetic process (GO:0006750)2.36929342
126indolalkylamine metabolic process (GO:0006586)2.36276987
127regulation of triglyceride biosynthetic process (GO:0010866)2.35303664
128regulation of cholesterol metabolic process (GO:0090181)2.35082730
129beta-amyloid metabolic process (GO:0050435)2.32680809
130ketone body metabolic process (GO:1902224)2.32677748
131cellular modified amino acid catabolic process (GO:0042219)2.32395756
132positive regulation of glycolytic process (GO:0045821)2.32206789
133response to unfolded protein (GO:0006986)2.32187905
134bile acid biosynthetic process (GO:0006699)2.31219272
135response to mercury ion (GO:0046689)2.30785791
136nucleotide transmembrane transport (GO:1901679)2.30783042
137amyloid precursor protein catabolic process (GO:0042987)2.30745397
138phosphatidylglycerol biosynthetic process (GO:0006655)2.30429406
139exogenous drug catabolic process (GO:0042738)2.28246753
140glandular epithelial cell differentiation (GO:0002067)2.27548457
141short-chain fatty acid metabolic process (GO:0046459)2.25515120
142phosphatidylinositol acyl-chain remodeling (GO:0036149)2.23904364
143NAD biosynthetic process (GO:0009435)2.23641963
144amyloid precursor protein metabolic process (GO:0042982)2.21689174
145epoxygenase P450 pathway (GO:0019373)2.21664999
146L-fucose metabolic process (GO:0042354)2.20452941
147L-fucose catabolic process (GO:0042355)2.20452941
148fucose catabolic process (GO:0019317)2.20452941
149indole-containing compound metabolic process (GO:0042430)2.19631981
150purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.19572499
1513-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.19572499
152positive regulation of CREB transcription factor activity (GO:0032793)2.19129486
153myelin maintenance (GO:0043217)2.17714609
154positive regulation of fatty acid oxidation (GO:0046321)2.17658706
155creatine metabolic process (GO:0006600)2.16959555
156cardiolipin metabolic process (GO:0032048)2.16138163
157female mating behavior (GO:0060180)2.15809216
158negative regulation of cell size (GO:0045792)2.15236088
159tryptophan metabolic process (GO:0006568)2.14190319
160peptide biosynthetic process (GO:0043043)2.13433185
161regulation of defense response to virus by host (GO:0050691)2.11223288
162regulation of sequestering of triglyceride (GO:0010889)2.10545430
163arginine metabolic process (GO:0006525)2.10306501
164fucosylation (GO:0036065)2.10163793
165regulation of memory T cell differentiation (GO:0043380)2.08845535
166proline metabolic process (GO:0006560)2.07790591
167catecholamine transport (GO:0051937)2.07601238
168regulation of female receptivity (GO:0045924)2.06660390
169positive regulation of prostaglandin secretion (GO:0032308)2.06212578
170nonribosomal peptide biosynthetic process (GO:0019184)2.05928424
171negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.03277476
172alkaloid metabolic process (GO:0009820)2.03003525
173phosphatidylethanolamine biosynthetic process (GO:0006646)2.01854406
174plasma membrane fusion (GO:0045026)2.00649706
175organelle membrane fusion (GO:0090174)2.00357053
176glycosylceramide metabolic process (GO:0006677)1.98722289
177regulation of apoptotic process involved in morphogenesis (GO:1902337)1.98495420
178nucleoside transmembrane transport (GO:1901642)1.97698150
179neurotransmitter catabolic process (GO:0042135)1.97635130
180deoxyribonucleoside monophosphate metabolic process (GO:0009162)1.97353266
181positive regulation of T cell mediated cytotoxicity (GO:0001916)1.96420327
182cornea development in camera-type eye (GO:0061303)1.96235827
183carbohydrate phosphorylation (GO:0046835)1.95499533
184lipopolysaccharide biosynthetic process (GO:0009103)1.95025676
185regulation of guanylate cyclase activity (GO:0031282)1.94726821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.39129175
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.18697711
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.11807632
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.84058860
5GATA1_22025678_ChIP-Seq_K562_Human3.29192416
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.28323713
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.25900815
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79892261
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.68460292
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.56363266
11CLOCK_20551151_ChIP-Seq_293T_Human2.52341020
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.47199552
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35012115
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.34405661
15BCL6_27268052_Chip-Seq_Bcells_Human2.27158686
16P68_20966046_ChIP-Seq_HELA_Human2.17564686
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.97032149
18ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.91767469
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90845343
20ELF1_20517297_ChIP-Seq_JURKAT_Human1.89947982
21LXR_22292898_ChIP-Seq_THP-1_Human1.89685848
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.89203064
23E2F1_20622854_ChIP-Seq_HELA_Human1.77635022
24DROSHA_22980978_ChIP-Seq_HELA_Human1.76502779
25TET1_21451524_ChIP-Seq_MESCs_Mouse1.75669436
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75125424
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74570523
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.72716012
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71012430
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.70922474
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.69610211
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68054920
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67475128
34CTCF_27219007_Chip-Seq_Bcells_Human1.64621247
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63170479
36CTCF_20526341_ChIP-Seq_ESCs_Human1.61907632
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57962891
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56203058
39PHF8_20622854_ChIP-Seq_HELA_Human1.52545631
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51673564
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51426239
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.51279336
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50865255
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.50487264
45STAT1_20625510_ChIP-Seq_HELA_Human1.47943485
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.47523513
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.46847973
48SMC4_20622854_ChIP-Seq_HELA_Human1.46750187
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.46272410
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45450258
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43289570
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42666838
53P300_27268052_Chip-Seq_Bcells_Human1.39324356
54SA1_27219007_Chip-Seq_Bcells_Human1.37344700
55FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.36911948
56RACK7_27058665_Chip-Seq_MCF-7_Human1.35193407
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35017896
58ERA_21632823_ChIP-Seq_H3396_Human1.34694687
59RAC3_21632823_ChIP-Seq_H3396_Human1.32863360
60RARB_24833708_ChIP-Seq_LIVER_Mouse1.31418931
61MYC_22102868_ChIP-Seq_BL_Human1.31129539
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30849988
63TP63_22573176_ChIP-Seq_HFKS_Human1.29174092
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29143015
65* SOX2_20726797_ChIP-Seq_SW620_Human1.27650483
66TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27394238
67CTCF_26484167_Chip-Seq_Bcells_Mouse1.27328832
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26803695
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.26721787
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24259151
71CTCF_21964334_ChIP-Seq_BJAB-B_Human1.22917226
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22234239
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22098315
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.21820412
75TAF2_19829295_ChIP-Seq_ESCs_Human1.20481483
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19977648
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19844577
78OCT4_20526341_ChIP-Seq_ESCs_Human1.19794933
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19576431
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.19137279
81* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16223979
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16128146
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13622278
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12682294
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.12667146
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11144885
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11083322
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.10163208
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09923226
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09635986
91SPI1_23127762_ChIP-Seq_K562_Human1.09330855
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.08898605
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.08898605
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08030139
95JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07975694
96MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07746478
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07531758
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07171597
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06749742
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06746970
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06333447
102EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06150518
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06077010
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06034757
105SPI1_20517297_ChIP-Seq_HL60_Human1.05750189
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05718016
107RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05157157
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05031127
109TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04916690
110VDR_24763502_ChIP-Seq_THP-1_Human1.04074107
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03651045
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03008748
113FOXA2_19822575_ChIP-Seq_HepG2_Human1.02730868
114GATA1_19941826_ChIP-Seq_K562_Human1.02687210
115P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.02374563
116MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02296724
117GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02201038
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02190896
119RUNX_20019798_ChIP-Seq_JUKART_Human1.02167661
120NANOG_20526341_ChIP-Seq_ESCs_Human1.02130500
121P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02060218
122IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00400127
123KDM2B_26808549_Chip-Seq_K562_Human1.00342884
124OCT4_19829295_ChIP-Seq_ESCs_Human1.00122439
125FOXH1_21741376_ChIP-Seq_ESCs_Human0.98782970
126RARA_24833708_ChIP-Seq_LIVER_Mouse0.98527501
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97991372
128CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96374348
129KDM2B_26808549_Chip-Seq_DND41_Human0.96248828
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96242593
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96074794
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95954992
133MAF_26560356_Chip-Seq_TH2_Human0.94973846
134MAF_26560356_Chip-Seq_TH1_Human0.94706130
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94439445
136RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93635115
137* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93054121
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92715291
139UTX_26944678_Chip-Seq_JUKART_Human0.92697830
140GATA4_25053715_ChIP-Seq_YYC3_Human0.92612471
141MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91940266
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91869555
143ATF3_27146783_Chip-Seq_COLON_Human0.91869310
144VDR_21846776_ChIP-Seq_THP-1_Human0.91547435
145TCF7_22412390_ChIP-Seq_EML_Mouse0.91482815
146CTCF_21964334_Chip-Seq_Bcells_Human0.90234813
147SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89645588
148LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89239568
149PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88910610
150GATA6_25053715_ChIP-Seq_YYC3_Human0.87584348
151GATA2_19941826_ChIP-Seq_K562_Human0.87003997
152NCOR1_26117541_ChIP-Seq_K562_Human0.86694135
153CREB1_26743006_Chip-Seq_LNCaP_Human0.86334954
154SCL_19346495_ChIP-Seq_HPC-7_Human0.86107917
155RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85956128
156ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85296025
157SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84515365
158SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83956066
159IRF8_27001747_Chip-Seq_BMDM_Mouse0.83890449
160BCOR_27268052_Chip-Seq_Bcells_Human0.83839245
161TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82746814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.21372554
2MP0005365_abnormal_bile_salt3.81078181
3MP0003191_abnormal_cellular_cholesterol3.60369593
4MP0002877_abnormal_melanocyte_morpholog2.97339315
5MP0005360_urolithiasis2.86668457
6MP0005058_abnormal_lysosome_morphology2.62187390
7MP0002876_abnormal_thyroid_physiology2.52426801
8MP0009840_abnormal_foam_cell2.41369687
9MP0005085_abnormal_gallbladder_physiolo2.38173777
10MP0000013_abnormal_adipose_tissue2.32191459
11MP0003252_abnormal_bile_duct2.31222917
12MP0010329_abnormal_lipoprotein_level2.19766714
13MP0001968_abnormal_touch/_nociception2.19088594
14MP0010386_abnormal_urinary_bladder2.18778355
15MP0005083_abnormal_biliary_tract2.13678461
16MP0003724_increased_susceptibility_to2.09196330
17MP0008875_abnormal_xenobiotic_pharmacok2.07091330
18MP0009643_abnormal_urine_homeostasis1.99935063
19MP0008438_abnormal_cutaneous_collagen1.98232361
20MP0002837_dystrophic_cardiac_calcinosis1.90014528
21MP0002909_abnormal_adrenal_gland1.85024741
22MP0003806_abnormal_nucleotide_metabolis1.84529819
23MP0001666_abnormal_nutrient_absorption1.84430300
24MP0001958_emphysema1.84079905
25MP0003879_abnormal_hair_cell1.78744056
26MP0005332_abnormal_amino_acid1.78403269
27MP0003646_muscle_fatigue1.76581984
28MP0001501_abnormal_sleep_pattern1.76322144
29MP0000681_abnormal_thyroid_gland1.75235765
30MP0004043_abnormal_pH_regulation1.73831381
31MP0003195_calcinosis1.73460570
32MP0003011_delayed_dark_adaptation1.72741545
33MP0001944_abnormal_pancreas_morphology1.70961923
34MP0004019_abnormal_vitamin_homeostasis1.68746906
35MP0008872_abnormal_physiological_respon1.66353031
36MP0001873_stomach_inflammation1.63945747
37MP0003183_abnormal_peptide_metabolism1.63479829
38MP0003172_abnormal_lysosome_physiology1.57401990
39MP0002118_abnormal_lipid_homeostasis1.55307062
40MP0005220_abnormal_exocrine_pancreas1.54511583
41MP0001756_abnormal_urination1.53582166
42MP0005319_abnormal_enzyme/_coenzyme1.52523981
43MP0003045_fibrosis1.50751060
44MP0002693_abnormal_pancreas_physiology1.48821979
45MP0006054_spinal_hemorrhage1.48402297
46MP0001664_abnormal_digestion1.48128087
47MP0002138_abnormal_hepatobiliary_system1.47418256
48MP0004147_increased_porphyrin_level1.44208315
49MP0002078_abnormal_glucose_homeostasis1.44013667
50MP0003300_gastrointestinal_ulcer1.43826555
51MP0001661_extended_life_span1.38642937
52MP0009780_abnormal_chondrocyte_physiolo1.38457501
53MP0000609_abnormal_liver_physiology1.37348449
54MP0005646_abnormal_pituitary_gland1.36961109
55MP0005670_abnormal_white_adipose1.35880269
56MP0000003_abnormal_adipose_tissue1.32490013
57MP0002736_abnormal_nociception_after1.30446410
58MP0002653_abnormal_ependyma_morphology1.29296115
59MP0008775_abnormal_heart_ventricle1.27973461
60MP0009333_abnormal_splenocyte_physiolog1.23838985
61MP0003329_amyloid_beta_deposits1.23600905
62MP0002249_abnormal_larynx_morphology1.21481018
63MP0003656_abnormal_erythrocyte_physiolo1.19392797
64MP0002090_abnormal_vision1.18787520
65MP0002733_abnormal_thermal_nociception1.17929936
66MP0010368_abnormal_lymphatic_system1.17085876
67MP0000604_amyloidosis1.15269628
68MP0004130_abnormal_muscle_cell1.15109431
69MP0005375_adipose_tissue_phenotype1.12469007
70MP0001765_abnormal_ion_homeostasis1.12140807
71MP0005451_abnormal_body_composition1.12065638
72MP0003705_abnormal_hypodermis_morpholog1.11834812
73MP0002933_joint_inflammation1.11111011
74MP0002064_seizures1.10824538
75MP0005636_abnormal_mineral_homeostasis1.09870124
76MP0000685_abnormal_immune_system1.08821274
77MP0002971_abnormal_brown_adipose1.08315292
78MP0009745_abnormal_behavioral_response1.06583063
79MP0001970_abnormal_pain_threshold1.06096347
80MP0005584_abnormal_enzyme/coenzyme_acti1.05457777
81MP0004885_abnormal_endolymph1.05416238
82MP0001533_abnormal_skeleton_physiology1.04521836
83MP0002148_abnormal_hypersensitivity_rea1.04413215
84MP0003075_altered_response_to1.04335113
85MP0005666_abnormal_adipose_tissue1.02942448
86MP0005000_abnormal_immune_tolerance1.01938959
87MP0009278_abnormal_bone_marrow1.01043756
88MP0001986_abnormal_taste_sensitivity1.00937271
89MP0001502_abnormal_circadian_rhythm0.99692292
90MP0010155_abnormal_intestine_physiology0.99638869
91MP0008469_abnormal_protein_level0.97990143
92MP0000230_abnormal_systemic_arterial0.97968749
93MP0008874_decreased_physiological_sensi0.97760422
94MP0002163_abnormal_gland_morphology0.96913591
95MP0009764_decreased_sensitivity_to0.95908863
96MP0004145_abnormal_muscle_electrophysio0.95206936
97MP0005410_abnormal_fertilization0.94997679
98MP0002822_catalepsy0.94491220
99MP0002136_abnormal_kidney_physiology0.94427451
100MP0002332_abnormal_exercise_endurance0.94048401
101MP0003866_abnormal_defecation0.93814352
102MP0004510_myositis0.92971324
103MP0003279_aneurysm0.92634178
104MP0000598_abnormal_liver_morphology0.92027729
105MP0005535_abnormal_body_temperature0.91893898
106MP0003436_decreased_susceptibility_to0.91111853
107MP0004264_abnormal_extraembryonic_tissu0.91074817
108MP0001764_abnormal_homeostasis0.90707803
109MP0003137_abnormal_impulse_conducting0.90486286
110MP0003283_abnormal_digestive_organ0.89707095
111MP0005671_abnormal_response_to0.89407185
112MP0003186_abnormal_redox_activity0.88681068
113MP0000538_abnormal_urinary_bladder0.87932375
114MP0000751_myopathy0.87708281
115MP0005025_abnormal_response_to0.87532808
116MP0002723_abnormal_immune_serum0.87333729
117MP0001800_abnormal_humoral_immune0.86757116
118MP0008961_abnormal_basal_metabolism0.85327118
119MP0003638_abnormal_response/metabolism_0.85234397
120MP0009642_abnormal_blood_homeostasis0.85025510
121MP0001663_abnormal_digestive_system0.84950147
122MP0005448_abnormal_energy_balance0.84880980
123MP0005464_abnormal_platelet_physiology0.83416649
124MP0000015_abnormal_ear_pigmentation0.83261616
125MP0005310_abnormal_salivary_gland0.82958126
126MP0006276_abnormal_autonomic_nervous0.82229244
127MP0002928_abnormal_bile_duct0.82166610
128MP0003953_abnormal_hormone_level0.81311142
129MP0005387_immune_system_phenotype0.80861629
130MP0001790_abnormal_immune_system0.80861629
131MP0000747_muscle_weakness0.79941251
132MP0006036_abnormal_mitochondrial_physio0.79333977
133MP0002896_abnormal_bone_mineralization0.79057461
134MP0006082_CNS_inflammation0.78085761
135MP0001542_abnormal_bone_strength0.77975584
136MP0005551_abnormal_eye_electrophysiolog0.77017706
137MP0001270_distended_abdomen0.76012227
138MP0005275_abnormal_skin_tensile0.75284887
139MP0005334_abnormal_fat_pad0.73766845
140MP0005330_cardiomyopathy0.73421463
141MP0000249_abnormal_blood_vessel0.73117294
142MP0004782_abnormal_surfactant_physiolog0.72465992
143MP0004036_abnormal_muscle_relaxation0.71011357
144MP0004185_abnormal_adipocyte_glucose0.69812013
145MP0004233_abnormal_muscle_weight0.69746563
146MP0000343_altered_response_to0.68418686
147MP0002269_muscular_atrophy0.68344803
148MP0010030_abnormal_orbit_morphology0.67412030
149MP0000678_abnormal_parathyroid_gland0.66974354
150MP0001845_abnormal_inflammatory_respons0.66662265
151MP0000749_muscle_degeneration0.66593647
152MP0002998_abnormal_bone_remodeling0.66102206
153MP0004087_abnormal_muscle_fiber0.65825361
154MP0000465_gastrointestinal_hemorrhage0.64123651
155MP0004272_abnormal_basement_membrane0.63876230

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)4.59197736
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.19729612
3Hypoglycemic coma (HP:0001325)4.13434841
4Dysostosis multiplex (HP:0000943)3.71783896
5Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.55400835
6Abnormality of fatty-acid metabolism (HP:0004359)3.52531316
7Ketoacidosis (HP:0001993)3.50766681
8Gout (HP:0001997)3.44415891
9Ketosis (HP:0001946)3.41948875
10Facial diplegia (HP:0001349)3.40677662
11Generalized aminoaciduria (HP:0002909)3.40626516
12Systemic lupus erythematosus (HP:0002725)3.37851109
13Vacuolated lymphocytes (HP:0001922)3.36451472
14Urinary glycosaminoglycan excretion (HP:0003541)3.30355371
15Mucopolysacchariduria (HP:0008155)3.30355371
16Hypoglycemic seizures (HP:0002173)3.14982223
17Hyperinsulinemic hypoglycemia (HP:0000825)3.12195250
18Abnormality of the intrinsic pathway (HP:0010989)3.11678432
19Deep venous thrombosis (HP:0002625)3.06822812
20Elevated erythrocyte sedimentation rate (HP:0003565)3.02139447
21Clumsiness (HP:0002312)2.98573282
22Abnormality of polysaccharide metabolism (HP:0011012)2.97854883
23Abnormality of glycosaminoglycan metabolism (HP:0004371)2.97854883
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.97854883
25Abnormal pancreas size (HP:0012094)2.97029484
26Abnormality of purine metabolism (HP:0004352)2.86890268
27Increased cerebral lipofuscin (HP:0011813)2.86368597
28Late onset (HP:0003584)2.86102482
29Complement deficiency (HP:0004431)2.85210894
30Hydroxyprolinuria (HP:0003080)2.82006034
31Abnormality of proline metabolism (HP:0010907)2.82006034
32Mesangial abnormality (HP:0001966)2.78553302
33Xanthomatosis (HP:0000991)2.77554112
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.75020244
35Retinal atrophy (HP:0001105)2.72832393
36Ragged-red muscle fibers (HP:0003200)2.68152947
37Intrahepatic cholestasis (HP:0001406)2.67000753
38Stridor (HP:0010307)2.62592008
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.59308422
40Visual hallucinations (HP:0002367)2.59129355
41Insulin-resistant diabetes mellitus (HP:0000831)2.58332250
42Abnormality of the common coagulation pathway (HP:0010990)2.56289015
43Congenital stationary night blindness (HP:0007642)2.55356270
44Tongue fasciculations (HP:0001308)2.53786204
45Hyperventilation (HP:0002883)2.53682495
46Hyperthyroidism (HP:0000836)2.48630103
47Polycythemia (HP:0001901)2.48467121
48Cerebral palsy (HP:0100021)2.47775048
49Increased purine levels (HP:0004368)2.45129447
50Hyperuricemia (HP:0002149)2.45129447
51Hyperglycemia (HP:0003074)2.44754593
52Skin nodule (HP:0200036)2.44605206
53Ileus (HP:0002595)2.44573406
54Symptomatic seizures (HP:0011145)2.42555889
55Mitral stenosis (HP:0001718)2.37177973
56Sensorimotor neuropathy (HP:0007141)2.36326154
57Hypoalphalipoproteinemia (HP:0003233)2.32356143
58Asymmetric septal hypertrophy (HP:0001670)2.31468437
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30558970
60Vascular calcification (HP:0004934)2.29307545
61Pigmentary retinal degeneration (HP:0001146)2.26462158
62Truncus arteriosus (HP:0001660)2.26034660
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25450538
64Dicarboxylic aciduria (HP:0003215)2.25450538
65Severe muscular hypotonia (HP:0006829)2.21670526
66Thin bony cortex (HP:0002753)2.20073225
67Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.18606543
68Muscle fibrillation (HP:0010546)2.18592586
69Abnormality of liposaccharide metabolism (HP:0010968)2.18256214
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.18256214
71Abnormality of glycolipid metabolism (HP:0010969)2.18256214
72Cardiovascular calcification (HP:0011915)2.18232864
73Type II lissencephaly (HP:0007260)2.16988009
74Anomalous pulmonary venous return (HP:0010772)2.16252382
75Amelogenesis imperfecta (HP:0000705)2.15256126
76Hyperlipoproteinemia (HP:0010980)2.13878978
77Glomerulonephritis (HP:0000099)2.13783449
78Hyperactive renin-angiotensin system (HP:0000841)2.12784512
79Insulin resistance (HP:0000855)2.12764797
80Hyperammonemia (HP:0001987)2.12712920
81Progressive neurologic deterioration (HP:0002344)2.12017543
82Congenital sensorineural hearing impairment (HP:0008527)2.11955148
83Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09992060
84Progressive microcephaly (HP:0000253)2.09508200
85Myoglobinuria (HP:0002913)2.06458570
86Abnormality of the pancreatic islet cells (HP:0006476)2.06422861
87Abnormality of endocrine pancreas physiology (HP:0012093)2.06422861
88Abnormality of nucleobase metabolism (HP:0010932)2.03915870
89Broad metatarsal (HP:0001783)2.03871967
90Myositis (HP:0100614)2.03035935
91Severe visual impairment (HP:0001141)2.00729090
92Ovoid vertebral bodies (HP:0003300)2.00560230
93Abnormality of alanine metabolism (HP:0010916)1.99054311
94Hyperalaninemia (HP:0003348)1.99054311
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99054311
96Prolonged QT interval (HP:0001657)1.99042366
97Pancreatic islet-cell hyperplasia (HP:0004510)1.97933915
98Alkalosis (HP:0001948)1.96883535
99Abnormal EKG (HP:0003115)1.96498099
100Cardiomegaly (HP:0001640)1.96232326
101Syncope (HP:0001279)1.96146065
102Beaking of vertebral bodies (HP:0004568)1.96046594
103Hypokalemia (HP:0002900)1.95380003
104Spondylolisthesis (HP:0003302)1.94638935
105Abnormality of complement system (HP:0005339)1.94147428
106Large for gestational age (HP:0001520)1.91795583
107Irritability (HP:0000737)1.91479740
108Nonimmune hydrops fetalis (HP:0001790)1.91029479
109Protuberant abdomen (HP:0001538)1.89511989
110Hand muscle atrophy (HP:0009130)1.88678988
111Microretrognathia (HP:0000308)1.87958969
112Cerebral aneurysm (HP:0004944)1.87837440
113Abnormality of the heme biosynthetic pathway (HP:0010472)1.86947437
114Hypolipoproteinemia (HP:0010981)1.84670414
115Hyperglycinuria (HP:0003108)1.84627491
116Acne (HP:0001061)1.84356664
117Aortic aneurysm (HP:0004942)1.83286159
118Nephritis (HP:0000123)1.83077245
119Infantile muscular hypotonia (HP:0008947)1.82807772
120Abnormality of the pulmonary veins (HP:0011718)1.82228807
121Generalized amyotrophy (HP:0003700)1.82049304
122Palpitations (HP:0001962)1.81913071
123Right ventricular cardiomyopathy (HP:0011663)1.81085454
124Fat malabsorption (HP:0002630)1.80343572
125Decreased circulating renin level (HP:0003351)1.79986095
126Abnormality of the odontoid process (HP:0003310)1.79897502
127Orchitis (HP:0100796)1.79713075
128Interstitial pulmonary disease (HP:0006530)1.79466804
129Axonal loss (HP:0003447)1.79417574
130Abnormality of glutamine family amino acid metabolism (HP:0010902)1.77515840
131Prolonged neonatal jaundice (HP:0006579)1.77463763
132Bulbar palsy (HP:0001283)1.77102017
133Joint stiffness (HP:0001387)1.75882692
134Abnormal rod and cone electroretinograms (HP:0008323)1.74745879
135Decreased subcutaneous fat (HP:0001002)1.74360290
136Deformed sella turcica (HP:0002681)1.74276771
137Difficulty walking (HP:0002355)1.74096788
138Proximal tubulopathy (HP:0000114)1.74019688
139EMG: myopathic abnormalities (HP:0003458)1.73909636
140Abdominal distention (HP:0003270)1.73203843
141Ventricular fibrillation (HP:0001663)1.72707265
142Abnormality of the aortic arch (HP:0012303)1.72533650
143Increased muscle lipid content (HP:0009058)1.72312541
144Metabolic acidosis (HP:0001942)1.72279980
145Hyperbilirubinemia (HP:0002904)1.71917796
146Upper limb amyotrophy (HP:0009129)1.70731968
147Distal upper limb amyotrophy (HP:0007149)1.70731968
148Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.70621379
149Opisthotonus (HP:0002179)1.69336854
150Dysautonomia (HP:0002459)1.68912021
151Genetic anticipation (HP:0003743)1.68643455
152Attenuation of retinal blood vessels (HP:0007843)1.65766592
153Hemorrhage of the eye (HP:0011885)1.65249733
154Pustule (HP:0200039)1.63658812
155Concave nail (HP:0001598)1.63545495
156Abnormality of transition element cation homeostasis (HP:0011030)1.63110788
157Retinal dysplasia (HP:0007973)1.62456735
158Tented upper lip vermilion (HP:0010804)1.62372305
159Abnormality of dental color (HP:0011073)1.62224658
160Increased serum ferritin (HP:0003281)1.56722331
161Abnormal gallbladder physiology (HP:0012438)1.56358617
162Cholecystitis (HP:0001082)1.56358617
163Optic neuritis (HP:0100653)1.55895283
164Retrobulbar optic neuritis (HP:0100654)1.55895283
165Ventricular arrhythmia (HP:0004308)1.55892417
166Hypoplasia of the odontoid process (HP:0003311)1.55546806
167Supraventricular tachycardia (HP:0004755)1.55303691
168Hypertensive crisis (HP:0100735)1.55118286
169Neonatal respiratory distress (HP:0002643)1.54989333
170Albinism (HP:0001022)1.53066315
171Cystic liver disease (HP:0006706)1.52404199
172Abnormality of the sella turcica (HP:0002679)1.52082801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.48285059
2TRIB33.60703588
3BCKDK3.27485173
4EEF2K2.61744907
5PKN22.42884657
6GRK62.35469771
7MAP2K32.32890227
8TGFBR22.32264347
9MAPK152.31710111
10MAPKAPK32.25656469
11SIK12.23066425
12PRKD32.14326896
13PTK62.11170311
14MAP3K32.04883530
15INSRR2.01567464
16MUSK1.94191283
17ZAP701.93870002
18ADRBK21.93412376
19MAP3K111.88561512
20TESK21.87773784
21BLK1.86388455
22GRK51.79262640
23FLT31.72300059
24WNK41.71483328
25TBK11.70846646
26TNK21.62385925
27DAPK21.61505708
28MAP4K11.59076542
29LMTK21.58210426
30MAP4K21.53434810
31FGFR41.51419722
32EPHA21.36659325
33TAOK31.33867028
34PASK1.33288886
35MAP3K21.32872648
36ACVR1B1.30895514
37TAOK11.27207212
38ADRBK11.25326415
39DYRK1B1.23149318
40IKBKB1.22968703
41MYLK1.22336743
42TAOK21.21994704
43PRKCH1.21118055
44GRK11.20805493
45PIK3CG1.20696250
46NEK91.20470361
47LIMK11.16820406
48PIM21.13538795
49IRAK21.12503244
50WNK31.11801825
51CAMKK11.10665125
52IRAK11.09757856
53ARAF1.08427025
54KIT1.05639874
55MAP3K11.05184429
56TTN1.04725657
57TXK1.04271986
58NTRK31.03613224
59HIPK21.00851594
60PINK11.00657961
61PRKD20.99743929
62NME20.98596069
63PDK20.98594656
64KDR0.98129265
65BMX0.98107461
66PDGFRA0.97922893
67PTK2B0.95891491
68CAMKK20.95251810
69IRAK40.91567622
70DAPK10.90083275
71PTK20.89516796
72RPS6KB20.88436253
73MAPK120.88183019
74LRRK20.86029974
75RIPK40.85133485
76PRKCI0.82830475
77TRPM70.82734889
78PRPF4B0.82335778
79RIPK10.79807667
80MAPKAPK50.78830367
81MATK0.77535793
82EPHB10.75291124
83JAK10.75196937
84BTK0.75160446
85IRAK30.74454461
86STK38L0.74242147
87FES0.71707090
88SYK0.71332755
89JAK20.69284217
90ITK0.69092144
91TYK20.68881179
92PRKD10.68616235
93RPS6KA60.68487805
94RET0.67634532
95MAP2K20.64755922
96TIE10.64290130
97MAP3K70.64168284
98ABL20.64163688
99SMG10.63194901
100TLK10.63095938
101MARK20.62291479
102SIK20.61877179
103STK380.60267228
104MAP3K50.60187593
105MAPK110.60132666
106PDPK10.59953711
107VRK20.57852222
108PRKG20.57431703
109EPHA30.57278205
110SCYL20.56750920
111CAMK2G0.56294392
112NTRK10.55910514
113RPS6KA20.55642584
114CSK0.55205860
115PRKAA10.54890058
116IKBKE0.54668309
117CAMK2B0.54468723
118FER0.52726964
119CAMK2D0.51638738
120MTOR0.50261798
121MAP2K60.50185043
122JAK30.49222904
123GRK70.48631459
124RPS6KC10.48417316
125RPS6KL10.48417316
126PIK3CA0.48053961
127PDK10.47520419
128EIF2AK10.47428870
129IGF1R0.47260107
130TESK10.46572639
131STK100.46379413
132PAK40.45609770
133PAK30.45386351
134MAPK130.45039814
135KSR20.44546348
136PAK60.42859751
137CDC42BPA0.42436712
138PRKAA20.42256279
139PHKG10.42241737
140PHKG20.42241737
141MAPKAPK20.41044665
142MAP2K10.40975771
143FRK0.39707343
144DAPK30.39053978
145MAPK70.39034529
146MAP3K60.38750071
147CAMK10.38450315
148MST1R0.37248922
149ILK0.36321064
150FGFR30.34220445
151PDGFRB0.33174339
152GSK3A0.30745150
153PAK20.28762624
154TGFBR10.27234238
155MAP3K100.25716722

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.18886458
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.29174809
3Sulfur metabolism_Homo sapiens_hsa009202.93806573
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43594548
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38752534
6Fatty acid degradation_Homo sapiens_hsa000712.32324449
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.29484019
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20939257
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15590136
10Tryptophan metabolism_Homo sapiens_hsa003802.14121095
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07735783
12Linoleic acid metabolism_Homo sapiens_hsa005912.06301205
13Lysosome_Homo sapiens_hsa041421.99364767
14Selenocompound metabolism_Homo sapiens_hsa004501.96426930
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92700652
16Butanoate metabolism_Homo sapiens_hsa006501.90445783
17Protein export_Homo sapiens_hsa030601.90187459
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.85188986
19Other glycan degradation_Homo sapiens_hsa005111.84013207
20Peroxisome_Homo sapiens_hsa041461.76513866
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.75855595
22Arachidonic acid metabolism_Homo sapiens_hsa005901.73354059
23Starch and sucrose metabolism_Homo sapiens_hsa005001.69123796
24Staphylococcus aureus infection_Homo sapiens_hsa051501.68704866
25PPAR signaling pathway_Homo sapiens_hsa033201.59447967
26ABC transporters_Homo sapiens_hsa020101.55419842
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53714834
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53258307
29Propanoate metabolism_Homo sapiens_hsa006401.52182579
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.51190849
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46515503
32Complement and coagulation cascades_Homo sapiens_hsa046101.44837669
33Ovarian steroidogenesis_Homo sapiens_hsa049131.40113115
34Fatty acid metabolism_Homo sapiens_hsa012121.38740945
35N-Glycan biosynthesis_Homo sapiens_hsa005101.38162350
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34948420
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32119246
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30207181
39Fructose and mannose metabolism_Homo sapiens_hsa000511.26113847
40Histidine metabolism_Homo sapiens_hsa003401.25148953
41Galactose metabolism_Homo sapiens_hsa000521.24040734
42Insulin resistance_Homo sapiens_hsa049311.22455131
43Folate biosynthesis_Homo sapiens_hsa007901.20260575
44Phenylalanine metabolism_Homo sapiens_hsa003601.19552593
45Ether lipid metabolism_Homo sapiens_hsa005651.17256887
46beta-Alanine metabolism_Homo sapiens_hsa004101.15216278
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13506340
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.10010347
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10005994
50Salivary secretion_Homo sapiens_hsa049701.08186554
51Bile secretion_Homo sapiens_hsa049761.07205563
52Fat digestion and absorption_Homo sapiens_hsa049751.03810584
53Arginine biosynthesis_Homo sapiens_hsa002201.03298684
54Nitrogen metabolism_Homo sapiens_hsa009101.03026444
55Primary immunodeficiency_Homo sapiens_hsa053401.02644335
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01750780
57Pyruvate metabolism_Homo sapiens_hsa006201.00516681
58Prion diseases_Homo sapiens_hsa050200.98921535
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.96359268
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96034558
61Tyrosine metabolism_Homo sapiens_hsa003500.94352073
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92117463
63Vibrio cholerae infection_Homo sapiens_hsa051100.92025743
64Fatty acid elongation_Homo sapiens_hsa000620.91462382
65Carbon metabolism_Homo sapiens_hsa012000.89975719
66Caffeine metabolism_Homo sapiens_hsa002320.88784532
67Morphine addiction_Homo sapiens_hsa050320.88249971
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87643148
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82743374
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82196878
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80946725
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79109633
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78424975
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77967669
75Circadian entrainment_Homo sapiens_hsa047130.77249379
76Phototransduction_Homo sapiens_hsa047440.76694007
77Synaptic vesicle cycle_Homo sapiens_hsa047210.74235138
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74096576
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73682373
80Glycerolipid metabolism_Homo sapiens_hsa005610.73657463
81Mineral absorption_Homo sapiens_hsa049780.73540594
82Protein digestion and absorption_Homo sapiens_hsa049740.72460853
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.70549393
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.70376566
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69349344
86Insulin secretion_Homo sapiens_hsa049110.69282159
87Chemical carcinogenesis_Homo sapiens_hsa052040.66218176
88Sulfur relay system_Homo sapiens_hsa041220.65531419
89Type II diabetes mellitus_Homo sapiens_hsa049300.64151643
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63589494
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63191491
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62796186
93Biosynthesis of amino acids_Homo sapiens_hsa012300.62702267
94Glutathione metabolism_Homo sapiens_hsa004800.60634457
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59544582
96Vitamin digestion and absorption_Homo sapiens_hsa049770.59469850
97Cholinergic synapse_Homo sapiens_hsa047250.59242014
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58800613
99Calcium signaling pathway_Homo sapiens_hsa040200.56858089
100Retinol metabolism_Homo sapiens_hsa008300.56325214
101Gastric acid secretion_Homo sapiens_hsa049710.55836980
102Legionellosis_Homo sapiens_hsa051340.53856449
103Circadian rhythm_Homo sapiens_hsa047100.53793569
104AMPK signaling pathway_Homo sapiens_hsa041520.51660483
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50796714
106Pertussis_Homo sapiens_hsa051330.50674042
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50460413
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50294673
109GABAergic synapse_Homo sapiens_hsa047270.48634061
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47231319
111Sphingolipid metabolism_Homo sapiens_hsa006000.45688146
112Metabolic pathways_Homo sapiens_hsa011000.45176871
113Olfactory transduction_Homo sapiens_hsa047400.44985953
114Insulin signaling pathway_Homo sapiens_hsa049100.44539802
115Taste transduction_Homo sapiens_hsa047420.44192808
116Arginine and proline metabolism_Homo sapiens_hsa003300.44145808
117Glutamatergic synapse_Homo sapiens_hsa047240.44049467
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42332251
119Leishmaniasis_Homo sapiens_hsa051400.41259379
120Hepatitis C_Homo sapiens_hsa051600.40717230
121Renin-angiotensin system_Homo sapiens_hsa046140.40384464
122Pentose phosphate pathway_Homo sapiens_hsa000300.39825696
123Glucagon signaling pathway_Homo sapiens_hsa049220.39642109
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38160188
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36843992
126TNF signaling pathway_Homo sapiens_hsa046680.36709323
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35493422
128Thyroid hormone synthesis_Homo sapiens_hsa049180.35492262
129Regulation of autophagy_Homo sapiens_hsa041400.34102207
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33922888
131Lysine degradation_Homo sapiens_hsa003100.33164776
132Collecting duct acid secretion_Homo sapiens_hsa049660.32726322
133Toxoplasmosis_Homo sapiens_hsa051450.32312072
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32200985
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32014475
136Amoebiasis_Homo sapiens_hsa051460.31992985
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.31680697
138Phagosome_Homo sapiens_hsa041450.31486670
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30428723
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28308415
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.26939326

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