FAM35DP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)5.45434070
2proteasome assembly (GO:0043248)4.44999211
3rRNA methylation (GO:0031167)3.72959053
4cullin deneddylation (GO:0010388)3.71347834
5rRNA modification (GO:0000154)3.68078969
6respiratory chain complex IV assembly (GO:0008535)3.51791477
7branched-chain amino acid catabolic process (GO:0009083)3.45327870
8establishment of protein localization to mitochondrial membrane (GO:0090151)3.41995189
9mitochondrial respiratory chain complex assembly (GO:0033108)3.39986491
10inner mitochondrial membrane organization (GO:0007007)3.38762588
11sequestering of actin monomers (GO:0042989)3.37632926
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35472878
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.35187617
14ribosome assembly (GO:0042255)3.26390157
15protein complex biogenesis (GO:0070271)3.26136522
16vitamin biosynthetic process (GO:0009110)3.24292954
17response to nitrosative stress (GO:0051409)3.23531494
18positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.22071387
19protein deneddylation (GO:0000338)3.20068344
20mitochondrial RNA metabolic process (GO:0000959)3.16212415
21DNA damage response, detection of DNA damage (GO:0042769)3.16153043
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14307254
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.14307254
24NADH dehydrogenase complex assembly (GO:0010257)3.14307254
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13680936
26IMP biosynthetic process (GO:0006188)3.12323078
27GTP biosynthetic process (GO:0006183)3.10478063
28platelet dense granule organization (GO:0060155)3.09716438
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09589382
30preassembly of GPI anchor in ER membrane (GO:0016254)3.06852869
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.05165815
32regulation of mitotic spindle checkpoint (GO:1903504)3.05165815
33RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.03123284
34protein neddylation (GO:0045116)2.97627553
35cytochrome complex assembly (GO:0017004)2.96158992
36purine nucleobase biosynthetic process (GO:0009113)2.94449092
37regulation of cellular amino acid metabolic process (GO:0006521)2.94206117
38somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.92988658
39isotype switching (GO:0045190)2.92988658
40somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.92988658
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92052880
42negative regulation of ligase activity (GO:0051352)2.92052880
43chromatin remodeling at centromere (GO:0031055)2.90294771
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89275143
45drug catabolic process (GO:0042737)2.88762754
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87101358
47lysine catabolic process (GO:0006554)2.86974541
48lysine metabolic process (GO:0006553)2.86974541
49bile acid biosynthetic process (GO:0006699)2.82085007
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81074628
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81074628
52IMP metabolic process (GO:0046040)2.78961480
53spliceosomal snRNP assembly (GO:0000387)2.78755917
54regulation of mitochondrial translation (GO:0070129)2.77300574
55nucleoside diphosphate phosphorylation (GO:0006165)2.77062442
56cholesterol biosynthetic process (GO:0006695)2.76833288
57ATP synthesis coupled proton transport (GO:0015986)2.76039506
58energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76039506
59glucuronate metabolic process (GO:0019585)2.74241793
60uronic acid metabolic process (GO:0006063)2.74241793
61L-serine metabolic process (GO:0006563)2.73178645
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73147121
63dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.71174945
64branched-chain amino acid metabolic process (GO:0009081)2.70815145
65histone mRNA metabolic process (GO:0008334)2.69038307
66exogenous drug catabolic process (GO:0042738)2.69017470
67tRNA metabolic process (GO:0006399)2.68491492
68neural tube formation (GO:0001841)2.67127651
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66277541
70CENP-A containing nucleosome assembly (GO:0034080)2.66205395
71tRNA aminoacylation for protein translation (GO:0006418)2.64626099
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63082935
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63082935
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63082935
75glyoxylate metabolic process (GO:0046487)2.63020371
76transcription elongation from RNA polymerase I promoter (GO:0006362)2.62860357
77AMP metabolic process (GO:0046033)2.62703440
78protein-cofactor linkage (GO:0018065)2.62101647
79nucleobase biosynthetic process (GO:0046112)2.60761173
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.59540338
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.59540338
82amino acid activation (GO:0043038)2.59405827
83tRNA aminoacylation (GO:0043039)2.59405827
84intestinal cholesterol absorption (GO:0030299)2.58945175
85lactate metabolic process (GO:0006089)2.58873670
86pteridine-containing compound biosynthetic process (GO:0042559)2.58473198
87tryptophan metabolic process (GO:0006568)2.57519140
88sterol biosynthetic process (GO:0016126)2.57371157
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.54626546
90tRNA processing (GO:0008033)2.54145239
91dopamine transport (GO:0015872)2.50883393
92L-alpha-amino acid transmembrane transport (GO:1902475)2.50573117
93aldehyde catabolic process (GO:0046185)2.50291425
94cellular glucuronidation (GO:0052695)2.50244408
95C4-dicarboxylate transport (GO:0015740)2.48902707
96UTP metabolic process (GO:0046051)2.48643134
97indolalkylamine metabolic process (GO:0006586)2.47519393
98UTP biosynthetic process (GO:0006228)2.47396690
99signal transduction involved in DNA damage checkpoint (GO:0072422)2.46338419
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.46338419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25320737
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.46893460
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.44491402
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.20200824
5IGF1R_20145208_ChIP-Seq_DFB_Human3.01129398
6ZNF274_21170338_ChIP-Seq_K562_Hela2.92762883
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.63567570
8ELK1_19687146_ChIP-ChIP_HELA_Human2.59672731
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52026239
10VDR_22108803_ChIP-Seq_LS180_Human2.42559813
11TAF15_26573619_Chip-Seq_HEK293_Human2.40310564
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.30767782
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20482420
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16596346
15FUS_26573619_Chip-Seq_HEK293_Human2.06712675
16E2F7_22180533_ChIP-Seq_HELA_Human2.04363717
17EWS_26573619_Chip-Seq_HEK293_Human1.99528548
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98092709
19VDR_23849224_ChIP-Seq_CD4+_Human1.96247945
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92132736
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91821212
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.91475179
23P300_19829295_ChIP-Seq_ESCs_Human1.90803560
24GBX2_23144817_ChIP-Seq_PC3_Human1.90556453
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86644672
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85844518
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79373308
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75007829
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71303786
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.70967375
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.65047163
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.64655296
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.64336406
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57415467
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56851935
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56192103
37FOXP3_21729870_ChIP-Seq_TREG_Human1.53878155
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53770201
39IRF1_19129219_ChIP-ChIP_H3396_Human1.47764967
40RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44314963
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.44167391
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.43735332
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41313685
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40861583
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39946805
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39387863
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35754148
48MYC_18940864_ChIP-ChIP_HL60_Human1.34137124
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33934157
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33070476
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31123892
52SOX2_19829295_ChIP-Seq_ESCs_Human1.29183045
53NANOG_19829295_ChIP-Seq_ESCs_Human1.29183045
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28836358
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26154115
56ER_23166858_ChIP-Seq_MCF-7_Human1.26123266
57BCAT_22108803_ChIP-Seq_LS180_Human1.23797699
58TP53_22573176_ChIP-Seq_HFKS_Human1.22969785
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.21785502
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20569312
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19382414
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17539445
63DCP1A_22483619_ChIP-Seq_HELA_Human1.16801407
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16031235
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15765739
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15709534
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15295177
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14402452
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.14402452
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13772230
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.13485334
72TCF4_22108803_ChIP-Seq_LS180_Human1.13145411
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12850296
74AR_21909140_ChIP-Seq_LNCAP_Human1.12774951
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12380846
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11968442
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.10680929
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10422998
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.08464046
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07881501
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.07520528
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.05820193
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04966783
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04538765
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03902660
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03739916
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03693456
88AR_20517297_ChIP-Seq_VCAP_Human1.03473089
89P300_18555785_Chip-Seq_ESCs_Mouse1.02652942
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02543561
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01162494
92CDX2_22108803_ChIP-Seq_LS180_Human1.00749472
93CBP_20019798_ChIP-Seq_JUKART_Human0.99697964
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99697964
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.98761054
96E2F1_18555785_Chip-Seq_ESCs_Mouse0.98503330
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98458509
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97863210
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95673065
100GABP_19822575_ChIP-Seq_HepG2_Human0.95662140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.30949808
2MP0008058_abnormal_DNA_repair3.21735559
3MP0005085_abnormal_gallbladder_physiolo3.17263855
4MP0002139_abnormal_hepatobiliary_system2.98972162
5MP0000372_irregular_coat_pigmentation2.84939340
6MP0000569_abnormal_digit_pigmentation2.79572537
7MP0006054_spinal_hemorrhage2.74072559
8MP0008875_abnormal_xenobiotic_pharmacok2.69180885
9MP0003693_abnormal_embryo_hatching2.64875338
10MP0003252_abnormal_bile_duct2.64491970
11MP0003806_abnormal_nucleotide_metabolis2.47545790
12MP0002102_abnormal_ear_morphology2.35353178
13MP0002254_reproductive_system_inflammat2.34870891
14MP0005365_abnormal_bile_salt2.32669945
15MP0005084_abnormal_gallbladder_morpholo2.30933175
16MP0003011_delayed_dark_adaptation2.20247713
17MP0003718_maternal_effect2.18578264
18MP0010094_abnormal_chromosome_stability2.11267527
19MP0005379_endocrine/exocrine_gland_phen2.08062081
20MP0001666_abnormal_nutrient_absorption2.04288959
21MP0001529_abnormal_vocalization2.02074719
22MP0005332_abnormal_amino_acid1.92683907
23MP0002163_abnormal_gland_morphology1.86079653
24MP0002938_white_spotting1.84630649
25MP0005551_abnormal_eye_electrophysiolog1.79698671
26MP0004133_heterotaxia1.75685907
27MP0006035_abnormal_mitochondrial_morpho1.73533631
28MP0003941_abnormal_skin_development1.72450800
29MP0003786_premature_aging1.69807237
30MP0001764_abnormal_homeostasis1.63302501
31MP0010329_abnormal_lipoprotein_level1.58808066
32MP0009697_abnormal_copulation1.58246390
33MP0006072_abnormal_retinal_apoptosis1.54775640
34MP0008995_early_reproductive_senescence1.52275208
35MP0005408_hypopigmentation1.51363761
36MP0006036_abnormal_mitochondrial_physio1.47979057
37MP0003186_abnormal_redox_activity1.42625380
38MP0002736_abnormal_nociception_after1.38409223
39MP0001293_anophthalmia1.38336146
40MP0001501_abnormal_sleep_pattern1.37467069
41MP0003880_abnormal_central_pattern1.37294898
42MP0004957_abnormal_blastocyst_morpholog1.37206671
43MP0006292_abnormal_olfactory_placode1.34456877
44MP0005647_abnormal_sex_gland1.33881406
45MP0001324_abnormal_eye_pigmentation1.33563834
46MP0002090_abnormal_vision1.33194030
47MP0004147_increased_porphyrin_level1.32608480
48MP0003122_maternal_imprinting1.31575785
49MP0005253_abnormal_eye_physiology1.29536028
50MP0004019_abnormal_vitamin_homeostasis1.28939435
51MP0000427_abnormal_hair_cycle1.28115504
52MP0006276_abnormal_autonomic_nervous1.22119814
53MP0000647_abnormal_sebaceous_gland1.17906976
54MP0003111_abnormal_nucleus_morphology1.11650686
55MP0005377_hearing/vestibular/ear_phenot1.05657276
56MP0003878_abnormal_ear_physiology1.05657276
57MP0000383_abnormal_hair_follicle1.04633944
58MP0003943_abnormal_hepatobiliary_system1.00858690
59MP0008932_abnormal_embryonic_tissue1.00177624
60MP0003136_yellow_coat_color0.99035562
61MP0005075_abnormal_melanosome_morpholog0.96746841
62MP0003077_abnormal_cell_cycle0.95949962
63MP0004142_abnormal_muscle_tone0.95198343
64MP0001485_abnormal_pinna_reflex0.91446516
65MP0002928_abnormal_bile_duct0.91169766
66MP0008877_abnormal_DNA_methylation0.91123664
67MP0001119_abnormal_female_reproductive0.89449247
68MP0003937_abnormal_limbs/digits/tail_de0.88459152
69MP0008872_abnormal_physiological_respon0.83859788
70MP0004742_abnormal_vestibular_system0.83321537
71MP0008007_abnormal_cellular_replicative0.82351576
72MP0005410_abnormal_fertilization0.79061589
73MP0003123_paternal_imprinting0.78829273
74MP0009764_decreased_sensitivity_to0.78465802
75MP0000371_diluted_coat_color0.78447133
76MP0005187_abnormal_penis_morphology0.77516858
77MP0002160_abnormal_reproductive_system0.77382869
78MP0005174_abnormal_tail_pigmentation0.75718079
79MP0005389_reproductive_system_phenotype0.73768869
80MP0003183_abnormal_peptide_metabolism0.73666286
81MP0005220_abnormal_exocrine_pancreas0.73215285
82MP0002233_abnormal_nose_morphology0.71513162
83MP0002138_abnormal_hepatobiliary_system0.70639955
84MP0005395_other_phenotype0.69122013
85MP0005310_abnormal_salivary_gland0.68904682
86MP0005646_abnormal_pituitary_gland0.68581140
87MP0005319_abnormal_enzyme/_coenzyme0.68279507
88MP0001177_atelectasis0.68116710
89MP0010386_abnormal_urinary_bladder0.66811465
90MP0000358_abnormal_cell_content/0.65213238
91MP0003121_genomic_imprinting0.64953161
92MP0002751_abnormal_autonomic_nervous0.64621242
93MP0000538_abnormal_urinary_bladder0.64101759
94MP0001286_abnormal_eye_development0.63356595
95MP0003868_abnormal_feces_composition0.62457933
96MP0000653_abnormal_sex_gland0.61667342
97MP0000598_abnormal_liver_morphology0.60909599
98MP0003567_abnormal_fetal_cardiomyocyte0.60012202
99MP0009672_abnormal_birth_weight0.59865194
100MP0000609_abnormal_liver_physiology0.58493508

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)3.77692341
2Lipid accumulation in hepatocytes (HP:0006561)3.59970907
3Abnormality of methionine metabolism (HP:0010901)3.52663879
4Hyperglycinemia (HP:0002154)3.45980331
5Increased serum pyruvate (HP:0003542)3.26521163
6Abnormality of glycine metabolism (HP:0010895)3.18423985
7Abnormality of serine family amino acid metabolism (HP:0010894)3.18423985
8Methylmalonic acidemia (HP:0002912)3.15562328
9Abnormality of serum amino acid levels (HP:0003112)3.14343331
10Prolonged partial thromboplastin time (HP:0003645)3.12840587
11Abnormality of aspartate family amino acid metabolism (HP:0010899)3.03973488
12Renal Fanconi syndrome (HP:0001994)2.94047094
13Hyperglycinuria (HP:0003108)2.81914567
14Acute encephalopathy (HP:0006846)2.81423821
15Abnormality of glycolysis (HP:0004366)2.74387950
16Pancreatic islet-cell hyperplasia (HP:0004510)2.73220749
17Increased CSF lactate (HP:0002490)2.71849062
18Aplasia/Hypoplasia of the fovea (HP:0008060)2.71769583
19Hypoplasia of the fovea (HP:0007750)2.71769583
20Intrahepatic cholestasis (HP:0001406)2.68797085
21Abnormality of alanine metabolism (HP:0010916)2.68399867
22Hyperalaninemia (HP:0003348)2.68399867
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68399867
24Hypobetalipoproteinemia (HP:0003563)2.62139289
25Meckel diverticulum (HP:0002245)2.61975741
26Intestinal atresia (HP:0011100)2.61644829
27Abolished electroretinogram (ERG) (HP:0000550)2.60188883
28Abnormality of the fovea (HP:0000493)2.59560763
29Mitochondrial inheritance (HP:0001427)2.55064319
30Abnormality of the ileum (HP:0001549)2.53866603
31Methylmalonic aciduria (HP:0012120)2.52041920
32True hermaphroditism (HP:0010459)2.51026061
33Increased intramyocellular lipid droplets (HP:0012240)2.47697181
34Spontaneous abortion (HP:0005268)2.46518836
35Short tibia (HP:0005736)2.44228317
36Increased serum lactate (HP:0002151)2.42307169
37Generalized aminoaciduria (HP:0002909)2.41246911
38Glycosuria (HP:0003076)2.39241538
39Abnormality of urine glucose concentration (HP:0011016)2.39241538
40Supernumerary spleens (HP:0009799)2.33321814
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.32106105
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31486626
43Hypothermia (HP:0002045)2.30787514
44Abnormality of the vitamin B12 metabolism (HP:0004341)2.29593573
45Medial flaring of the eyebrow (HP:0010747)2.27743992
46Pancreatic cysts (HP:0001737)2.27635279
47Exertional dyspnea (HP:0002875)2.26934885
48Abnormality of vitamin B metabolism (HP:0004340)2.26639215
49Cerebral edema (HP:0002181)2.26584419
50Abnormality of the labia minora (HP:0012880)2.25906436
51Hepatocellular necrosis (HP:0001404)2.25283977
52Acute necrotizing encephalopathy (HP:0006965)2.24702407
53Hepatic necrosis (HP:0002605)2.21725110
54Reduced antithrombin III activity (HP:0001976)2.18742982
55Pancreatic fibrosis (HP:0100732)2.18683793
56Abnormality of chromosome stability (HP:0003220)2.16756021
57Type 2 muscle fiber atrophy (HP:0003554)2.15881809
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10867556
59Lethargy (HP:0001254)2.02223464
60Increased muscle lipid content (HP:0009058)1.97929599
61Arthropathy (HP:0003040)1.96243653
62Aplasia/Hypoplasia of the uvula (HP:0010293)1.95441758
63Type I transferrin isoform profile (HP:0003642)1.94866837
64Lactic acidosis (HP:0003128)1.94026796
65Attenuation of retinal blood vessels (HP:0007843)1.93952978
66Renal cortical cysts (HP:0000803)1.93736215
67Chronic hepatic failure (HP:0100626)1.93471737
68Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92672539
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92672539
70Progressive macrocephaly (HP:0004481)1.92361723
71Hypoglycemic coma (HP:0001325)1.92348380
72Abnormal mitochondria in muscle tissue (HP:0008316)1.90973077
73Abnormality of sulfur amino acid metabolism (HP:0004339)1.88768312
74Abnormality of vitamin metabolism (HP:0100508)1.88479451
75Hyperphosphaturia (HP:0003109)1.84524037
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84018642
77Respiratory difficulties (HP:0002880)1.83544003
783-Methylglutaconic aciduria (HP:0003535)1.82486532
79Pancytopenia (HP:0001876)1.81766248
80Abnormal lung lobation (HP:0002101)1.81485554
81Hypolipoproteinemia (HP:0010981)1.81443087
82Abnormality of midbrain morphology (HP:0002418)1.80976529
83Molar tooth sign on MRI (HP:0002419)1.80976529
84Hyperammonemia (HP:0001987)1.79838080
85Aplasia/Hypoplasia of the macula (HP:0008059)1.79813093
86Congenital stationary night blindness (HP:0007642)1.79709736
87Abnormality of renal resorption (HP:0011038)1.79299881
88Nephronophthisis (HP:0000090)1.78692439
89Bilateral microphthalmos (HP:0007633)1.78526851
90Decreased central vision (HP:0007663)1.78434582
91Abnormal protein glycosylation (HP:0012346)1.78346418
92Abnormal glycosylation (HP:0012345)1.78346418
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78346418
94Abnormal protein N-linked glycosylation (HP:0012347)1.78346418
95Gonadotropin excess (HP:0000837)1.73925558
96Homocystinuria (HP:0002156)1.73109297
97Abnormality of homocysteine metabolism (HP:0010919)1.73109297
98Abnormality of the preputium (HP:0100587)1.72318543
99Colon cancer (HP:0003003)1.70948067
100Sloping forehead (HP:0000340)1.70924462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.46502054
2TSSK63.08454726
3TRIM283.08450350
4MAP4K22.96799590
5PBK2.53369003
6NUAK12.46955393
7WNK32.43706088
8ACVR1B2.40680573
9SRPK12.35609363
10EIF2AK12.23733344
11BCKDK2.15605811
12TAF11.98853155
13PLK31.98377178
14ADRBK21.96487842
15NEK11.95103654
16MST41.89796546
17FRK1.82253789
18STK161.81803286
19BMPR1B1.81151460
20ERBB31.80679617
21PINK11.78494943
22MKNK11.75676905
23NME11.70597279
24MAP3K121.69507114
25GRK71.69094446
26ZAK1.66121722
27BUB11.62685839
28MKNK21.51496943
29TNIK1.48846003
30WNK41.47684969
31STK38L1.42253444
32FER1.30599326
33BRSK21.29525549
34IRAK11.12830595
35PDK21.09862052
36STK391.09001580
37FGFR11.08966955
38BCR1.08408535
39GRK11.08321345
40CSNK1G11.04279449
41EIF2AK21.02017003
42PAK31.01108875
43PLK21.00964185
44BMPR21.00510129
45FGR1.00004940
46FLT31.00003557
47CDK30.98540647
48CDC70.96958553
49PLK10.85181636
50RPS6KA40.83881546
51ERBB40.83402312
52ALK0.83343604
53WEE10.82900608
54VRK10.81426211
55TGFBR10.81040560
56MAP3K90.77134474
57PLK40.77085631
58CSNK1G30.76525977
59MAPK130.76322204
60DAPK10.75898934
61VRK20.75449258
62PRKCE0.72922256
63CASK0.70911717
64TGFBR20.70734706
65OXSR10.69949926
66TEC0.68470194
67TTK0.66231590
68STK30.63788796
69NLK0.59066899
70BLK0.56476238
71INSRR0.55006842
72CSNK1A1L0.52943694
73DYRK30.52550266
74NEK60.51379162
75MUSK0.51291123
76IRAK20.49458734
77ATR0.47509553
78CSNK1G20.47498649
79PASK0.46766024
80PRKG20.45684071
81DAPK20.45031247
82TIE10.44887198
83CAMK2A0.44479452
84AURKB0.40889798
85CSNK2A10.39443065
86STK100.38928724
87DYRK20.38701389
88ATM0.38659103
89MET0.38070914
90MAP2K60.37995657
91PNCK0.37307862
92ADRBK10.35002415
93CSNK2A20.34992304
94CSNK1A10.33658892
95PRKACB0.32181183
96IKBKE0.30695156
97YES10.30285405
98TAOK10.27887361
99MATK0.26790108
100STK40.26669636

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.33548343
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73461375
3Propanoate metabolism_Homo sapiens_hsa006402.64505178
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.46646528
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18589586
6Protein export_Homo sapiens_hsa030602.17189224
7Butanoate metabolism_Homo sapiens_hsa006502.16716483
8Non-homologous end-joining_Homo sapiens_hsa034502.16086832
9One carbon pool by folate_Homo sapiens_hsa006702.03071632
10Vitamin B6 metabolism_Homo sapiens_hsa007501.99970629
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96007683
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91613285
13Oxidative phosphorylation_Homo sapiens_hsa001901.91140897
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91107176
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90705783
16Caffeine metabolism_Homo sapiens_hsa002321.85772276
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.84874352
18Steroid biosynthesis_Homo sapiens_hsa001001.83417552
19Basal transcription factors_Homo sapiens_hsa030221.75745983
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70924099
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70135156
22Pyruvate metabolism_Homo sapiens_hsa006201.67047774
23Parkinsons disease_Homo sapiens_hsa050121.64947599
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.60864847
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58744467
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58185476
27Fatty acid elongation_Homo sapiens_hsa000621.58080528
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57072381
29Tryptophan metabolism_Homo sapiens_hsa003801.54431068
30RNA polymerase_Homo sapiens_hsa030201.54175168
31Selenocompound metabolism_Homo sapiens_hsa004501.52732103
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52127845
33RNA degradation_Homo sapiens_hsa030181.50430263
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49513462
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48732061
36Fatty acid degradation_Homo sapiens_hsa000711.45533338
37Mismatch repair_Homo sapiens_hsa034301.44597544
38RNA transport_Homo sapiens_hsa030131.38941337
39Glutathione metabolism_Homo sapiens_hsa004801.37220443
40Chemical carcinogenesis_Homo sapiens_hsa052041.36277717
41beta-Alanine metabolism_Homo sapiens_hsa004101.34576922
42Retinol metabolism_Homo sapiens_hsa008301.26423259
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25779019
44Nucleotide excision repair_Homo sapiens_hsa034201.18965697
45DNA replication_Homo sapiens_hsa030301.18260794
46Peroxisome_Homo sapiens_hsa041461.17928720
47Homologous recombination_Homo sapiens_hsa034401.17887824
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15690768
49Fat digestion and absorption_Homo sapiens_hsa049751.13668738
50Complement and coagulation cascades_Homo sapiens_hsa046101.13501033
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.12565449
52Linoleic acid metabolism_Homo sapiens_hsa005911.11666187
53Fanconi anemia pathway_Homo sapiens_hsa034601.10923126
54Sulfur metabolism_Homo sapiens_hsa009201.06232264
55Spliceosome_Homo sapiens_hsa030401.05502288
56Huntingtons disease_Homo sapiens_hsa050161.02157551
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97921738
58Pyrimidine metabolism_Homo sapiens_hsa002400.97835100
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96690672
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.93038689
61Vitamin digestion and absorption_Homo sapiens_hsa049770.90080704
62Fatty acid metabolism_Homo sapiens_hsa012120.89923836
63Purine metabolism_Homo sapiens_hsa002300.85898042
64Metabolic pathways_Homo sapiens_hsa011000.85586340
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84639710
66Alzheimers disease_Homo sapiens_hsa050100.83109951
67N-Glycan biosynthesis_Homo sapiens_hsa005100.82966926
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82549760
69Carbon metabolism_Homo sapiens_hsa012000.76183581
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75830201
71Arginine and proline metabolism_Homo sapiens_hsa003300.73392091
72Arachidonic acid metabolism_Homo sapiens_hsa005900.73317854
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73007695
74Ether lipid metabolism_Homo sapiens_hsa005650.72965838
75Nitrogen metabolism_Homo sapiens_hsa009100.72328351
76Biosynthesis of amino acids_Homo sapiens_hsa012300.66988786
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65325162
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60256677
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59806246
80Base excision repair_Homo sapiens_hsa034100.59698227
81Starch and sucrose metabolism_Homo sapiens_hsa005000.58422231
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.57477884
83Histidine metabolism_Homo sapiens_hsa003400.56080176
84Folate biosynthesis_Homo sapiens_hsa007900.53468375
85Phototransduction_Homo sapiens_hsa047440.50446988
86Tyrosine metabolism_Homo sapiens_hsa003500.50386324
87PPAR signaling pathway_Homo sapiens_hsa033200.43076342
88p53 signaling pathway_Homo sapiens_hsa041150.41982403
89Collecting duct acid secretion_Homo sapiens_hsa049660.41720171
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40610717
91Ribosome_Homo sapiens_hsa030100.39567214
92Arginine biosynthesis_Homo sapiens_hsa002200.35951923
93Cardiac muscle contraction_Homo sapiens_hsa042600.31712887
94Glycerolipid metabolism_Homo sapiens_hsa005610.28474309
95ABC transporters_Homo sapiens_hsa020100.27556305
96Legionellosis_Homo sapiens_hsa051340.27409034
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26045297
98Regulation of autophagy_Homo sapiens_hsa041400.26009059
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25604997
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25145224

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