FAM229B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)8.73400085
2acrosome reaction (GO:0007340)8.14543068
3cilium or flagellum-dependent cell motility (GO:0001539)7.67877860
4axonemal dynein complex assembly (GO:0070286)7.67509480
5motile cilium assembly (GO:0044458)7.48941161
6fusion of sperm to egg plasma membrane (GO:0007342)7.41658676
7acrosome assembly (GO:0001675)7.28823420
8multicellular organism reproduction (GO:0032504)7.17094921
9cell wall macromolecule metabolic process (GO:0044036)6.94610842
10cell wall macromolecule catabolic process (GO:0016998)6.94610842
11epithelial cilium movement (GO:0003351)6.90855810
12sperm-egg recognition (GO:0035036)6.46466846
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.19194476
14cilium movement (GO:0003341)6.14769451
15spermatid development (GO:0007286)6.14389818
16piRNA metabolic process (GO:0034587)6.11196454
17male meiosis (GO:0007140)5.81399413
18cell-cell recognition (GO:0009988)5.75472624
19reproduction (GO:0000003)5.68686586
20binding of sperm to zona pellucida (GO:0007339)5.66753820
21plasma membrane fusion (GO:0045026)5.62228227
22microtubule depolymerization (GO:0007019)5.52373964
23regulation of cilium movement (GO:0003352)5.10819222
24DNA methylation involved in gamete generation (GO:0043046)4.98943296
25single fertilization (GO:0007338)4.97274757
26synaptonemal complex organization (GO:0070193)4.75808928
27pyrimidine nucleobase catabolic process (GO:0006208)4.64559537
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.59994158
29synaptonemal complex assembly (GO:0007130)4.59634949
30negative regulation of inclusion body assembly (GO:0090084)4.59245981
31sperm capacitation (GO:0048240)4.49961837
32spermatogenesis (GO:0007283)4.44810492
33male gamete generation (GO:0048232)4.42846483
34male meiosis I (GO:0007141)4.30033600
35ventricular system development (GO:0021591)4.28300153
36gamete generation (GO:0007276)4.22962533
37fertilization (GO:0009566)4.22837062
38energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21839734
39ATP synthesis coupled proton transport (GO:0015986)4.21839734
40organic cation transport (GO:0015695)4.05264461
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02478659
42protein K11-linked deubiquitination (GO:0035871)3.91484945
43calcium ion-dependent exocytosis (GO:0017156)3.87529553
44regulation of spindle checkpoint (GO:0090231)3.84768397
45nucleobase catabolic process (GO:0046113)3.76198296
46behavioral response to nicotine (GO:0035095)3.76068468
47mitotic sister chromatid cohesion (GO:0007064)3.74602377
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.71435547
49positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.71317362
50nonmotile primary cilium assembly (GO:0035058)3.69587604
51centriole assembly (GO:0098534)3.59635175
52microtubule severing (GO:0051013)3.56735966
53germ cell development (GO:0007281)3.56649787
54sequestering of actin monomers (GO:0042989)3.56536284
55cellular process involved in reproduction in multicellular organism (GO:0022412)3.55283225
56respiratory electron transport chain (GO:0022904)3.54768274
57electron transport chain (GO:0022900)3.53366079
58protein complex biogenesis (GO:0070271)3.49346760
59DNA packaging (GO:0006323)3.47953312
60protein localization to cilium (GO:0061512)3.47443431
61presynaptic membrane assembly (GO:0097105)3.45925452
62presynaptic membrane organization (GO:0097090)3.45893314
63sulfate transmembrane transport (GO:1902358)3.39414858
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38694226
65mitochondrial respiratory chain complex I assembly (GO:0032981)3.38694226
66NADH dehydrogenase complex assembly (GO:0010257)3.38694226
67cilium morphogenesis (GO:0060271)3.38553644
68chromosome organization involved in meiosis (GO:0070192)3.37666831
69microtubule polymerization or depolymerization (GO:0031109)3.34591687
70multicellular organismal reproductive process (GO:0048609)3.29586580
71regulation of inclusion body assembly (GO:0090083)3.27253737
72retinal ganglion cell axon guidance (GO:0031290)3.26061414
73centriole replication (GO:0007099)3.24141832
74cell recognition (GO:0008037)3.23415159
75spermatid nucleus differentiation (GO:0007289)3.23351541
76axoneme assembly (GO:0035082)3.19643219
77cilium organization (GO:0044782)3.19553242
78meiosis I (GO:0007127)3.18749705
79G-protein coupled receptor internalization (GO:0002031)3.17344379
80postsynaptic membrane organization (GO:0001941)3.16427093
81mitochondrial respiratory chain complex assembly (GO:0033108)3.14376125
82cilium assembly (GO:0042384)3.13601256
83maintenance of protein location in nucleus (GO:0051457)3.13550836
84gamma-aminobutyric acid transport (GO:0015812)3.12724119
85transmission of nerve impulse (GO:0019226)3.12591586
86neuron cell-cell adhesion (GO:0007158)3.11920104
87meiotic nuclear division (GO:0007126)3.10825140
88single strand break repair (GO:0000012)3.10345234
89neuron fate determination (GO:0048664)3.05420273
90histone H3-K4 trimethylation (GO:0080182)3.04761039
91chaperone-mediated protein transport (GO:0072321)3.04662155
92axonal fasciculation (GO:0007413)3.02065855
93chromosome condensation (GO:0030261)3.01283662
94RNA destabilization (GO:0050779)3.01132005
95left/right pattern formation (GO:0060972)2.97649796
96sulfate transport (GO:0008272)2.95590056
97protein polyglutamylation (GO:0018095)2.93651765
98neuron recognition (GO:0008038)2.91851278
99cellular component assembly involved in morphogenesis (GO:0010927)2.84594682
100positive regulation of CREB transcription factor activity (GO:0032793)2.83442660
101auditory behavior (GO:0031223)2.82941055
102protein neddylation (GO:0045116)2.82267282
103seminiferous tubule development (GO:0072520)2.81078309
104meiotic cell cycle (GO:0051321)2.79978840
105smoothened signaling pathway (GO:0007224)2.78992484
106multicellular organismal development (GO:0007275)2.77648153
107monoubiquitinated protein deubiquitination (GO:0035520)2.77043383
108microtubule bundle formation (GO:0001578)2.75880951
109positive regulation of icosanoid secretion (GO:0032305)2.74792961
110hydrogen ion transmembrane transport (GO:1902600)2.73085797
111positive regulation of gastrulation (GO:2000543)2.69797376
112histone H2B ubiquitination (GO:0033523)2.67130243
113ATP biosynthetic process (GO:0006754)2.65922788
114central nervous system myelination (GO:0022010)2.65502994
115axon ensheathment in central nervous system (GO:0032291)2.65502994
116vocalization behavior (GO:0071625)2.63706361
117urinary tract smooth muscle contraction (GO:0014848)2.62741436
118substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.61912122
119substrate-independent telencephalic tangential migration (GO:0021826)2.61912122
120spinal cord association neuron differentiation (GO:0021527)2.61449606
121purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.61304527
122regulation of mitotic spindle checkpoint (GO:1903504)2.61216189
123regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61216189
124genitalia morphogenesis (GO:0035112)2.59214767
125DNA alkylation (GO:0006305)2.58526334
126DNA methylation (GO:0006306)2.58526334
127spinal cord motor neuron differentiation (GO:0021522)2.58524333
128protein localization to synapse (GO:0035418)2.58240031
129purine nucleoside triphosphate biosynthetic process (GO:0009145)2.57392612
130calcium ion import (GO:0070509)2.57100594
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56152114
132proton transport (GO:0015992)2.55660975
133sister chromatid cohesion (GO:0007062)2.55220163
134regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55189692
135dendritic spine morphogenesis (GO:0060997)2.54194487
136intraciliary transport (GO:0042073)2.54034535
137establishment of mitochondrion localization (GO:0051654)2.52538808
138positive regulation of heat generation (GO:0031652)2.51453509
139hydrogen transport (GO:0006818)2.51130782
140cell differentiation in spinal cord (GO:0021515)2.50860758
141nucleoside diphosphate phosphorylation (GO:0006165)2.50519584
142determination of left/right symmetry (GO:0007368)2.50065004
143protein-cofactor linkage (GO:0018065)2.49520095
144aldehyde catabolic process (GO:0046185)2.48756784
145synapsis (GO:0007129)2.48462870
146histone H3-K9 methylation (GO:0051567)2.47887338
147synapse assembly (GO:0007416)2.47192343
148GTP biosynthetic process (GO:0006183)2.46680035
149limb bud formation (GO:0060174)2.46630648
150positive regulation of mitochondrial fission (GO:0090141)2.45589298
151positive regulation of meiosis (GO:0045836)2.45553441
152regulation of microtubule-based movement (GO:0060632)2.45528875
153response to pheromone (GO:0019236)2.44274359
154neurofilament cytoskeleton organization (GO:0060052)2.44271111
155mechanosensory behavior (GO:0007638)2.42963087
156viral transcription (GO:0019083)2.42712421
157platelet dense granule organization (GO:0060155)2.42441815
158translational termination (GO:0006415)2.41140411
159positive regulation of fatty acid transport (GO:2000193)2.41117911
160left/right axis specification (GO:0070986)2.41104718
161short-term memory (GO:0007614)2.40754458
162regulation of synapse structural plasticity (GO:0051823)2.40265984
163regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.39922321
164female gonad development (GO:0008585)2.38910130
165detection of light stimulus involved in sensory perception (GO:0050962)2.38523104
166detection of light stimulus involved in visual perception (GO:0050908)2.38523104
167somite development (GO:0061053)2.38370172
168startle response (GO:0001964)2.38157659
169positive regulation of synapse assembly (GO:0051965)2.37518810
170negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37331122
171regulation of fever generation (GO:0031620)2.36750726
172microtubule-based movement (GO:0007018)2.35437456
173appendage development (GO:0048736)2.35414523
174limb development (GO:0060173)2.35414523
175neural tube formation (GO:0001841)2.35385912
176determination of bilateral symmetry (GO:0009855)2.33962191
177G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32911307
178neurotransmitter-gated ion channel clustering (GO:0072578)2.31856954
179intracellular protein transmembrane import (GO:0044743)2.30352859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.74357091
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.61869092
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.09673154
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.02165776
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.95244813
6GBX2_23144817_ChIP-Seq_PC3_Human2.61745118
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56257048
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.55064493
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.49476467
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45111155
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35578455
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21664485
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17593617
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.14192373
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03596496
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.02669502
17NFE2_27457419_Chip-Seq_LIVER_Mouse2.02357412
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.91596293
19TAF15_26573619_Chip-Seq_HEK293_Human1.91462427
20TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.89213958
21IGF1R_20145208_ChIP-Seq_DFB_Human1.84739199
22NANOG_18555785_Chip-Seq_ESCs_Mouse1.83798658
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83628397
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.81396320
25EWS_26573619_Chip-Seq_HEK293_Human1.80479450
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80439113
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78181473
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73772235
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.70212484
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66703584
31EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.63934063
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63028016
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62648954
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62648954
35VDR_22108803_ChIP-Seq_LS180_Human1.62607186
36RNF2_27304074_Chip-Seq_NSC_Mouse1.62115974
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.60177374
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.59453627
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59045303
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.59009669
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.58564335
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58316803
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.58206325
44P53_22387025_ChIP-Seq_ESCs_Mouse1.57450732
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55736235
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55706210
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.55088069
48CMYC_18555785_Chip-Seq_ESCs_Mouse1.54127910
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.53886068
50REST_21632747_ChIP-Seq_MESCs_Mouse1.51376340
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50451070
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50064580
53OCT4_18555785_Chip-Seq_ESCs_Mouse1.48552853
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.46749401
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46714255
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46506818
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.45114466
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44469361
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44218320
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44201062
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.43218956
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.42211232
63P300_18555785_Chip-Seq_ESCs_Mouse1.41756933
64SMAD4_21799915_ChIP-Seq_A2780_Human1.40197022
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39770300
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.39091041
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38959212
68KDM2B_26808549_Chip-Seq_REH_Human1.37924006
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37423755
70ESRRB_18555785_Chip-Seq_ESCs_Mouse1.37053987
71ER_23166858_ChIP-Seq_MCF-7_Human1.36916053
72P300_19829295_ChIP-Seq_ESCs_Human1.36121737
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.35936768
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33796425
75RUNX1_27457419_Chip-Seq_LIVER_Mouse1.33769125
76FUS_26573619_Chip-Seq_HEK293_Human1.32757728
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31380700
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31224624
79KLF4_18555785_Chip-Seq_ESCs_Mouse1.30909525
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30552572
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28848155
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.28637346
83CBP_20019798_ChIP-Seq_JUKART_Human1.28321702
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28321702
85ELK4_26923725_Chip-Seq_MESODERM_Mouse1.28143745
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27778693
87AR_25329375_ChIP-Seq_VCAP_Human1.27473603
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.27268836
89PU1_27457419_Chip-Seq_LIVER_Mouse1.26898462
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26658944
91ZFX_18555785_Chip-Seq_ESCs_Mouse1.26509640
92ZNF274_21170338_ChIP-Seq_K562_Hela1.26137389
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.24489550
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23922516
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23373621
96TCF4_23295773_ChIP-Seq_U87_Human1.23072573
97GF1_26923725_Chip-Seq_HPCs_Mouse1.21737748
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.21317478
99RNF2_27304074_Chip-Seq_ESCs_Mouse1.20689538
100EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20467712
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20467712
102JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19321534
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.17937223
104STAT3_23295773_ChIP-Seq_U87_Human1.17759296
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17695340
106TBL1_22424771_ChIP-Seq_293T_Human1.16999783
107SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16467197
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16357138
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16304340
110SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15465463
111EZH2_27294783_Chip-Seq_ESCs_Mouse1.15129715
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14399208
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14110760
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14033697
115LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13594425
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13431668
117MYC_18940864_ChIP-ChIP_HL60_Human1.13409794
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12307579
119TP53_22573176_ChIP-Seq_HFKS_Human1.11293388
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10542205
121SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10015027
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09396285
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08744987
124RUNX2_22187159_ChIP-Seq_PCA_Human1.08517694
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08404664
126BCAT_22108803_ChIP-Seq_LS180_Human1.08135428
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08111777
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07838062
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07595457
130IRF1_19129219_ChIP-ChIP_H3396_Human1.07558766
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07533166
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06866483
133FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05986295
134ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05485525
135WDR5_24793694_ChIP-Seq_LNCAP_Human1.04804595
136SALL1_21062744_ChIP-ChIP_HESCs_Human1.04444831
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03276171
138STAT1_17558387_ChIP-Seq_HELA_Human1.02941460
139TCF4_22108803_ChIP-Seq_LS180_Human1.02675716
140SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02267746
141NFYB_21822215_ChIP-Seq_K562_Human1.01433287
142KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01147942
143TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00474249
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99851507
145SOX2_19829295_ChIP-Seq_ESCs_Human0.99772184
146NANOG_19829295_ChIP-Seq_ESCs_Human0.99772184
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96815436
148ELK1_19687146_ChIP-ChIP_HELA_Human0.96104165
149JUN_21703547_ChIP-Seq_K562_Human0.95983032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.55621840
2MP0000566_synostosis5.29313596
3MP0005257_abnormal_intraocular_pressure4.63592757
4MP0008877_abnormal_DNA_methylation3.60883363
5MP0003698_abnormal_male_reproductive3.60273461
6MP0001929_abnormal_gametogenesis3.06285449
7MP0006292_abnormal_olfactory_placode2.72394788
8MP0003787_abnormal_imprinting2.43337014
9MP0002102_abnormal_ear_morphology2.26442085
10MP0000569_abnormal_digit_pigmentation2.25228137
11MP0002163_abnormal_gland_morphology2.24010911
12MP0002210_abnormal_sex_determination2.19792593
13MP0002822_catalepsy2.00177013
14MP0005670_abnormal_white_adipose1.96459754
15MP0004133_heterotaxia1.94151878
16MP0005645_abnormal_hypothalamus_physiol1.93103710
17MP0008789_abnormal_olfactory_epithelium1.90011423
18MP0002161_abnormal_fertility/fecundity1.87437176
19MP0001486_abnormal_startle_reflex1.86754304
20MP0005379_endocrine/exocrine_gland_phen1.81321659
21MP0002277_abnormal_respiratory_mucosa1.76937805
22MP0005394_taste/olfaction_phenotype1.71853975
23MP0005499_abnormal_olfactory_system1.71853975
24MP0004142_abnormal_muscle_tone1.70669663
25MP0009379_abnormal_foot_pigmentation1.65253292
26MP0001145_abnormal_male_reproductive1.64290807
27MP0009046_muscle_twitch1.58904725
28MP0005646_abnormal_pituitary_gland1.58445386
29MP0006072_abnormal_retinal_apoptosis1.55230746
30MP0001346_abnormal_lacrimal_gland1.53384653
31MP0001986_abnormal_taste_sensitivity1.52719721
32MP0003011_delayed_dark_adaptation1.50005816
33MP0001188_hyperpigmentation1.48513386
34MP0002837_dystrophic_cardiac_calcinosis1.47409932
35MP0000653_abnormal_sex_gland1.46328180
36MP0000955_abnormal_spinal_cord1.45415829
37MP0004885_abnormal_endolymph1.42726659
38MP0003136_yellow_coat_color1.42157921
39MP0001485_abnormal_pinna_reflex1.40085812
40MP0005451_abnormal_body_composition1.39224329
41MP0004742_abnormal_vestibular_system1.37046169
42MP0001984_abnormal_olfaction1.36599240
43MP0003283_abnormal_digestive_organ1.34248539
44MP0002234_abnormal_pharynx_morphology1.34045626
45MP0001905_abnormal_dopamine_level1.32080138
46MP0000049_abnormal_middle_ear1.30130380
47MP0009250_abnormal_appendicular_skeleto1.26928910
48MP0001849_ear_inflammation1.26030424
49MP0010030_abnormal_orbit_morphology1.25114046
50MP0002736_abnormal_nociception_after1.21373231
51MP0002572_abnormal_emotion/affect_behav1.21240217
52MP0001293_anophthalmia1.20765976
53MP0003880_abnormal_central_pattern1.20078033
54MP0005551_abnormal_eye_electrophysiolog1.19787806
55MP0000372_irregular_coat_pigmentation1.19613135
56MP0005423_abnormal_somatic_nervous1.15611692
57MP0008057_abnormal_DNA_replication1.11378794
58MP0001299_abnormal_eye_distance/1.10758265
59MP0002282_abnormal_trachea_morphology1.08328979
60MP0001963_abnormal_hearing_physiology1.08011524
61MP0001968_abnormal_touch/_nociception1.08003865
62MP0002733_abnormal_thermal_nociception1.07664813
63MP0002735_abnormal_chemical_nociception1.06636355
64MP0002751_abnormal_autonomic_nervous1.04700670
65MP0001440_abnormal_grooming_behavior1.03707552
66MP0005187_abnormal_penis_morphology0.99716721
67MP0003938_abnormal_ear_development0.98721743
68MP0004859_abnormal_synaptic_plasticity0.98229758
69MP0001529_abnormal_vocalization0.97646056
70MP0003890_abnormal_embryonic-extraembry0.97226222
71MP0008058_abnormal_DNA_repair0.96675604
72MP0000778_abnormal_nervous_system0.95932609
73MP0002152_abnormal_brain_morphology0.95555387
74MP0002909_abnormal_adrenal_gland0.94470344
75MP0008875_abnormal_xenobiotic_pharmacok0.94197281
76MP0002734_abnormal_mechanical_nocicepti0.94031351
77MP0009745_abnormal_behavioral_response0.93808316
78MP0005386_behavior/neurological_phenoty0.93732283
79MP0004924_abnormal_behavior0.93732283
80MP0000026_abnormal_inner_ear0.93494676
81MP0000631_abnormal_neuroendocrine_gland0.92967974
82MP0003121_genomic_imprinting0.92248272
83MP0004811_abnormal_neuron_physiology0.92050315
84MP0005310_abnormal_salivary_gland0.90981352
85MP0003635_abnormal_synaptic_transmissio0.90964948
86MP0003861_abnormal_nervous_system0.90710625
87MP0000579_abnormal_nail_morphology0.89833514
88MP0002938_white_spotting0.89779762
89MP0005084_abnormal_gallbladder_morpholo0.88064982
90MP0004145_abnormal_muscle_electrophysio0.87447201
91MP0003195_calcinosis0.87433042
92MP0002272_abnormal_nervous_system0.86843980
93MP0005391_vision/eye_phenotype0.84402350
94MP0002249_abnormal_larynx_morphology0.82424113
95MP0003119_abnormal_digestive_system0.82360214
96MP0005253_abnormal_eye_physiology0.81940928
97MP0002067_abnormal_sensory_capabilities0.81760386
98MP0003045_fibrosis0.81519217
99MP0002066_abnormal_motor_capabilities/c0.80929795
100MP0004043_abnormal_pH_regulation0.80344261
101MP0005409_darkened_coat_color0.80078945
102MP0003942_abnormal_urinary_system0.80026015
103MP0002557_abnormal_social/conspecific_i0.79787756
104MP0003937_abnormal_limbs/digits/tail_de0.79519047
105MP0000015_abnormal_ear_pigmentation0.79378097
106MP0002697_abnormal_eye_size0.78828349
107MP0001324_abnormal_eye_pigmentation0.78794365
108MP0002928_abnormal_bile_duct0.78736346
109MP0001501_abnormal_sleep_pattern0.78320595
110MP0001851_eye_inflammation0.77319432
111MP0002063_abnormal_learning/memory/cond0.76374940
112MP0002160_abnormal_reproductive_system0.76149904
113MP0002752_abnormal_somatic_nervous0.75805697
114MP0002116_abnormal_craniofacial_bone0.75215357
115MP0008995_early_reproductive_senescence0.74680980
116MP0002064_seizures0.74475877
117MP0004185_abnormal_adipocyte_glucose0.73946036
118MP0000432_abnormal_head_morphology0.73571988
119MP0005171_absent_coat_pigmentation0.72251439
120MP0002638_abnormal_pupillary_reflex0.70837236
121MP0002653_abnormal_ependyma_morphology0.70354576
122MP0001502_abnormal_circadian_rhythm0.70224555
123MP0003122_maternal_imprinting0.69949011
124MP0002396_abnormal_hematopoietic_system0.68718825
125MP0005174_abnormal_tail_pigmentation0.68404314
126MP0004270_analgesia0.67575981
127MP0005377_hearing/vestibular/ear_phenot0.67195998
128MP0003878_abnormal_ear_physiology0.67195998
129MP0006276_abnormal_autonomic_nervous0.67088934
130MP0003646_muscle_fatigue0.66689106
131MP0002184_abnormal_innervation0.64418346
132MP0001970_abnormal_pain_threshold0.62984814
133MP0004381_abnormal_hair_follicle0.62959427
134MP0003950_abnormal_plasma_membrane0.62692103
135MP0002109_abnormal_limb_morphology0.62445117
136MP0000462_abnormal_digestive_system0.61511215
137MP0002233_abnormal_nose_morphology0.59050063
138MP0003755_abnormal_palate_morphology0.59007509
139MP0005195_abnormal_posterior_eye0.58395766
140MP0002882_abnormal_neuron_morphology0.57521170

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.37403030
2Absent/shortened dynein arms (HP:0200106)9.37403030
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.29782190
4Abnormal respiratory motile cilium physiology (HP:0012261)7.02901872
5Abnormal respiratory motile cilium morphology (HP:0005938)6.67717453
6Abnormal respiratory epithelium morphology (HP:0012253)6.67717453
7Abnormal ciliary motility (HP:0012262)6.33028247
8Rhinitis (HP:0012384)5.04968488
9Nephronophthisis (HP:0000090)4.10711762
10Chronic bronchitis (HP:0004469)4.10645232
11Infertility (HP:0000789)3.75542204
12Abnormality of the renal medulla (HP:0100957)3.37351659
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28915756
14Acute necrotizing encephalopathy (HP:0006965)3.19079912
15Tubulointerstitial nephritis (HP:0001970)3.04388906
16Bronchiectasis (HP:0002110)3.03423750
17Abnormality of midbrain morphology (HP:0002418)3.02752718
18Molar tooth sign on MRI (HP:0002419)3.02752718
19Chromsome breakage (HP:0040012)2.95029435
20Myokymia (HP:0002411)2.94359836
21Mitochondrial inheritance (HP:0001427)2.89656007
22Nasal polyposis (HP:0100582)2.85233665
23Sclerocornea (HP:0000647)2.84731376
24Large eyes (HP:0001090)2.84017877
25Abnormal mitochondria in muscle tissue (HP:0008316)2.81477453
26Decreased central vision (HP:0007663)2.78721707
27Progressive macrocephaly (HP:0004481)2.76502696
28Genital tract atresia (HP:0001827)2.76294647
29Acute encephalopathy (HP:0006846)2.71132868
30Vaginal atresia (HP:0000148)2.70266297
31Medial flaring of the eyebrow (HP:0010747)2.67733544
32Impulsivity (HP:0100710)2.61447177
33Anencephaly (HP:0002323)2.57190968
34Ectopic kidney (HP:0000086)2.55860414
35Recurrent sinusitis (HP:0011108)2.54070579
36Increased CSF lactate (HP:0002490)2.46385651
37Polyphagia (HP:0002591)2.45531653
38Hepatocellular necrosis (HP:0001404)2.43605516
39Prostate neoplasm (HP:0100787)2.41237724
40Congenital hepatic fibrosis (HP:0002612)2.40095567
41Increased hepatocellular lipid droplets (HP:0006565)2.39858980
42Pendular nystagmus (HP:0012043)2.36506239
43Abnormality of the labia minora (HP:0012880)2.32135391
44Limb dystonia (HP:0002451)2.31573735
45Hypoplasia of the capital femoral epiphysis (HP:0003090)2.30824890
46Lipid accumulation in hepatocytes (HP:0006561)2.28675965
47Hepatic necrosis (HP:0002605)2.28020271
48Small epiphyses (HP:0010585)2.25472746
49Febrile seizures (HP:0002373)2.25072145
50Pancreatic fibrosis (HP:0100732)2.24824269
51Recurrent otitis media (HP:0000403)2.20411096
52Cystic liver disease (HP:0006706)2.16390441
53Type II lissencephaly (HP:0007260)2.15291573
54Poor coordination (HP:0002370)2.15157735
55True hermaphroditism (HP:0010459)2.12482614
56Short femoral neck (HP:0100864)2.11972610
57Postaxial foot polydactyly (HP:0001830)2.11490393
58Renal Fanconi syndrome (HP:0001994)2.07611224
59Narrow forehead (HP:0000341)2.05619044
60Specific learning disability (HP:0001328)2.05558641
61Abnormality of the nasal mucosa (HP:0000433)2.04846764
62Focal motor seizures (HP:0011153)2.04824945
63Male infertility (HP:0003251)2.02504530
64Abnormal number of erythroid precursors (HP:0012131)1.97608288
65Renal dysplasia (HP:0000110)1.97363327
66Chronic hepatic failure (HP:0100626)1.96829809
67Anophthalmia (HP:0000528)1.96107473
68Polydipsia (HP:0001959)1.95072942
69Abnormal drinking behavior (HP:0030082)1.95072942
70Abnormality of the intervertebral disk (HP:0005108)1.93366752
71Progressive cerebellar ataxia (HP:0002073)1.92979157
72Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.92921969
73Optic nerve hypoplasia (HP:0000609)1.91968218
74Bronchitis (HP:0012387)1.90357361
75Dyschromatopsia (HP:0007641)1.90292333
76Hyperventilation (HP:0002883)1.89671549
77Anomalous pulmonary venous return (HP:0010772)1.89557242
78Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89392392
79Absent epiphyses (HP:0010577)1.89392392
80Cerebral edema (HP:0002181)1.89361761
81Abnormality of cells of the erythroid lineage (HP:0012130)1.88907161
82Furrowed tongue (HP:0000221)1.88534716
83Optic disc pallor (HP:0000543)1.88086254
84Tubulointerstitial abnormality (HP:0001969)1.87403872
85Abnormality of incisor morphology (HP:0011063)1.86388160
86Aplasia cutis congenita (HP:0001057)1.84391495
87Median cleft lip (HP:0000161)1.83405236
88Hyperglycinemia (HP:0002154)1.82804713
89Poor suck (HP:0002033)1.80798445
90Retinal dysplasia (HP:0007973)1.78980675
913-Methylglutaconic aciduria (HP:0003535)1.77088568
92Focal seizures (HP:0007359)1.76230937
93Lissencephaly (HP:0001339)1.75758365
94Postaxial hand polydactyly (HP:0001162)1.75571640
95Concave nail (HP:0001598)1.75390831
96Supernumerary spleens (HP:0009799)1.74195759
97Congenital malformation of the right heart (HP:0011723)1.73021093
98Double outlet right ventricle (HP:0001719)1.73021093
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.71802817
100Widely spaced teeth (HP:0000687)1.71223450
101Hemiparesis (HP:0001269)1.71009059
102Chronic sinusitis (HP:0011109)1.70548135
103Drooling (HP:0002307)1.70104161
104Preaxial hand polydactyly (HP:0001177)1.69962981
105Pancreatic cysts (HP:0001737)1.69289417
106Clubbing of toes (HP:0100760)1.68707353
107Abnormality of the nasal septum (HP:0000419)1.68602347
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67772262
109Abnormal spermatogenesis (HP:0008669)1.67703569
110Left ventricular hypertrophy (HP:0001712)1.67054111
111Oligodactyly (hands) (HP:0001180)1.66440951
112Pachygyria (HP:0001302)1.65875315
113Midline defect of the nose (HP:0004122)1.65597192
114Broad-based gait (HP:0002136)1.65498554
115Abnormal biliary tract physiology (HP:0012439)1.64941895
116Bile duct proliferation (HP:0001408)1.64941895
117Congenital stationary night blindness (HP:0007642)1.63578445
118Polyuria (HP:0000103)1.63433391
119Absent septum pellucidum (HP:0001331)1.62226884
120Abnormality of the pulmonary veins (HP:0011718)1.62139687
121Aplasia/Hypoplasia of the lens (HP:0008063)1.61897610
122Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.61868479
123Decreased activity of mitochondrial respiratory chain (HP:0008972)1.61868479
124Prominent nasal bridge (HP:0000426)1.61808083
125Male pseudohermaphroditism (HP:0000037)1.60017086
126Decreased testicular size (HP:0008734)1.59321535
127Abnormality of molar (HP:0011077)1.58932379
128Abnormality of molar morphology (HP:0011070)1.58932379
129Broad foot (HP:0001769)1.58861497
130Fibular hypoplasia (HP:0003038)1.58544151
131Abnormality of the preputium (HP:0100587)1.58308622
132Abnormality of the dental root (HP:0006486)1.57138365
133Taurodontia (HP:0000679)1.57138365
134Abnormality of permanent molar morphology (HP:0011071)1.57138365
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.56435197
136Tubular atrophy (HP:0000092)1.56175553
137Duplicated collecting system (HP:0000081)1.55942036
138Attenuation of retinal blood vessels (HP:0007843)1.54569586
139Stage 5 chronic kidney disease (HP:0003774)1.54373243
140Nephrogenic diabetes insipidus (HP:0009806)1.54168227
141Patchy hypopigmentation of hair (HP:0011365)1.53709804
142Absent rod-and cone-mediated responses on ERG (HP:0007688)1.53642334
143Oculomotor apraxia (HP:0000657)1.53578451
144Lip pit (HP:0100267)1.53537972
145Abnormality of the renal cortex (HP:0011035)1.53344817
146Abnormality of the parietal bone (HP:0002696)1.53024932
147Gait imbalance (HP:0002141)1.52641872
148Flattened epiphyses (HP:0003071)1.52556957
149Congenital primary aphakia (HP:0007707)1.51253054
150Abnormality of the dental pulp (HP:0006479)1.50940995
151Limited hip movement (HP:0008800)1.50137626
152Absent frontal sinuses (HP:0002688)1.49297918
153Aganglionic megacolon (HP:0002251)1.49152089
154Septo-optic dysplasia (HP:0100842)1.47412862
155Hip dysplasia (HP:0001385)1.45445435
156Occipital encephalocele (HP:0002085)1.43748709
157Abnormality of the renal collecting system (HP:0004742)1.43380073
158Abnormal rod and cone electroretinograms (HP:0008323)1.43131329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.80809746
2PDK33.67229138
3PDK43.67229138
4CDK123.45234874
5WNK33.17288529
6CDK82.66711678
7PDK22.51193651
8DYRK22.35924378
9ICK2.21460390
10TNIK2.08258929
11CASK2.05362960
12PRKD31.99398416
13CAMK1G1.97635595
14SIK21.95809233
15NTRK31.89977402
16SIK31.89504486
17MAP4K21.89329806
18BCR1.86226438
19STK381.83075317
20TRIM281.80390688
21INSRR1.77434296
22RIPK41.76039366
23PNCK1.72014788
24LATS11.70545464
25MUSK1.64945357
26FRK1.60331284
27MAPK151.59190003
28STK38L1.58655795
29STK391.53161338
30PTK2B1.49837490
31CSNK1G21.49670370
32PLK41.47057063
33CHEK21.46614467
34NTRK21.45534819
35GRK71.42095366
36CAMK1D1.40855575
37TESK11.35098683
38PRKCG1.34502408
39CDC71.33642418
40NUAK11.33443857
41VRK21.33205585
42PAK31.31296896
43MAP2K71.30620319
44EIF2AK21.27963812
45MINK11.27633647
46CDK31.26923012
47STK31.26265217
48ADRBK21.24526204
49TXK1.24322645
50NEK21.22870993
51MAPK131.21060997
52MARK21.20419141
53DYRK31.18712719
54WNK11.18299986
55WNK41.17717769
56BCKDK1.16711923
57CSNK1G31.15387359
58MAP2K41.15375885
59PHKG21.13032697
60PHKG11.13032697
61ERBB31.12201137
62DMPK1.10456026
63CSNK1G11.05206100
64UHMK11.03787188
65MAP3K61.02260275
66CDK191.01169617
67FGFR20.99755759
68PRPF4B0.99336544
69MAP3K120.98947988
70WEE10.96704867
71CSNK1A1L0.95938128
72ZAK0.92797113
73PRKCE0.91349683
74TLK10.90556851
75NME10.88288099
76PKN10.85752836
77DYRK1A0.84577231
78MAP3K40.83163100
79OXSR10.81301092
80SRPK10.79504790
81MARK30.78781286
82PLK30.78002611
83CDK70.77171168
84GRK10.76375659
85PLK20.75785201
86FGR0.75571937
87ERBB40.74985467
88LIMK10.74365319
89STK160.73654001
90SGK2230.71425137
91SGK4940.71425137
92MKNK20.69648912
93TTK0.69554965
94TAOK10.68715784
95AKT30.68055415
96PRKD20.68012726
97TIE10.67354311
98CCNB10.65657287
99EPHA40.65302625
100BRD40.64612786
101PASK0.63479131
102NEK60.63248131
103BMPR20.62255288
104PRKAA20.61372971
105EPHA30.60780695
106TAF10.60639858
107ADRBK10.60351406
108YES10.59761174
109DYRK1B0.59697199
110CDK50.59539473
111CAMK10.59254975
112PRKACA0.57955015
113CHEK10.57395621
114ATM0.57360333
115IRAK10.55659130
116BMPR1B0.55059406
117MAPK100.54880103
118TAOK30.54317661
119GRK50.53911446
120CAMK40.53049319
121ATR0.51735548
122DAPK20.50625042
123TNK20.50588724
124TGFBR10.50577472
125VRK10.46901499
126OBSCN0.46149332
127MAPK140.45842959
128SGK10.45296933
129EPHB20.45021189
130GSK3B0.44689594
131CSNK1A10.44604375
132LATS20.43792171
133PRKCZ0.42410325
134CAMK2A0.42120725
135PRKAA10.41989323
136PRKG10.41989122
137MKNK10.41975591
138TSSK60.41662609
139CAMK2B0.40122401
140ERBB20.39780236
141CDK140.39742263
142BRSK20.39368691
143CAMKK20.39225737
144PDK10.38789835
145PRKACB0.38689564
146PLK10.38597065
147RPS6KA50.38176131
148STK110.36995762
149PAK60.36879191
150AURKA0.36503853
151CSNK1E0.36077884
152MST40.35520892
153MAPKAPK50.34787317
154CDC42BPA0.34020839
155BLK0.33037007
156CDK10.32944905
157PINK10.32081083
158RPS6KA30.31947164
159SGK20.31106741
160TEC0.28432524

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.27721942
2Basal transcription factors_Homo sapiens_hsa030223.91340008
3Parkinsons disease_Homo sapiens_hsa050123.58022941
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.89937801
5Nicotine addiction_Homo sapiens_hsa050332.74388786
6Protein export_Homo sapiens_hsa030602.65480425
7Ribosome_Homo sapiens_hsa030102.61547698
8Alzheimers disease_Homo sapiens_hsa050102.53901185
9Fanconi anemia pathway_Homo sapiens_hsa034602.17458609
10Taste transduction_Homo sapiens_hsa047421.94979798
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91910371
12Butanoate metabolism_Homo sapiens_hsa006501.90222323
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83462938
14Fatty acid biosynthesis_Homo sapiens_hsa000611.79550855
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74384554
16Ether lipid metabolism_Homo sapiens_hsa005651.72453132
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69578491
18Linoleic acid metabolism_Homo sapiens_hsa005911.68025947
19Phototransduction_Homo sapiens_hsa047441.64690564
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61377677
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61271517
22Amphetamine addiction_Homo sapiens_hsa050311.60400772
23RNA polymerase_Homo sapiens_hsa030201.59894586
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.58551540
25Propanoate metabolism_Homo sapiens_hsa006401.50199442
26Morphine addiction_Homo sapiens_hsa050321.49390817
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.49191079
28Glutamatergic synapse_Homo sapiens_hsa047241.48970926
29Steroid biosynthesis_Homo sapiens_hsa001001.47342080
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46085728
31Vitamin B6 metabolism_Homo sapiens_hsa007501.40326342
32Calcium signaling pathway_Homo sapiens_hsa040201.39430523
33Renin secretion_Homo sapiens_hsa049241.36843871
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.31553731
35Dorso-ventral axis formation_Homo sapiens_hsa043201.26292773
36Olfactory transduction_Homo sapiens_hsa047401.24707750
37Insulin secretion_Homo sapiens_hsa049111.22661767
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22446926
39Salivary secretion_Homo sapiens_hsa049701.21602716
40Autoimmune thyroid disease_Homo sapiens_hsa053201.21399276
41cAMP signaling pathway_Homo sapiens_hsa040241.20561959
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17815615
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16839209
44Circadian entrainment_Homo sapiens_hsa047131.15713009
45Proteasome_Homo sapiens_hsa030501.13530260
46Mineral absorption_Homo sapiens_hsa049781.12305647
47Chemical carcinogenesis_Homo sapiens_hsa052041.09926627
48Serotonergic synapse_Homo sapiens_hsa047261.09587868
49Peroxisome_Homo sapiens_hsa041461.09332071
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09319711
51Glucagon signaling pathway_Homo sapiens_hsa049221.08926854
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06952978
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06507831
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06081385
55Cocaine addiction_Homo sapiens_hsa050301.04684710
56Sphingolipid metabolism_Homo sapiens_hsa006001.03711478
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03593689
58beta-Alanine metabolism_Homo sapiens_hsa004101.01270474
59Nitrogen metabolism_Homo sapiens_hsa009101.00720944
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00521803
61Long-term potentiation_Homo sapiens_hsa047200.98086552
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98007838
63Axon guidance_Homo sapiens_hsa043600.97551326
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.97308098
65Arachidonic acid metabolism_Homo sapiens_hsa005900.96440601
66Wnt signaling pathway_Homo sapiens_hsa043100.95724964
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.92932884
68Type II diabetes mellitus_Homo sapiens_hsa049300.92608877
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.91681755
70Collecting duct acid secretion_Homo sapiens_hsa049660.90923443
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87967026
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87761819
73Homologous recombination_Homo sapiens_hsa034400.86277471
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86158456
75Tryptophan metabolism_Homo sapiens_hsa003800.85634042
76Rheumatoid arthritis_Homo sapiens_hsa053230.84829289
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82596505
78Oxytocin signaling pathway_Homo sapiens_hsa049210.82467908
79Fatty acid elongation_Homo sapiens_hsa000620.81047143
80mRNA surveillance pathway_Homo sapiens_hsa030150.79863442
81Folate biosynthesis_Homo sapiens_hsa007900.78304354
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.78034985
83Pyruvate metabolism_Homo sapiens_hsa006200.77593870
84Inositol phosphate metabolism_Homo sapiens_hsa005620.77000466
85Metabolic pathways_Homo sapiens_hsa011000.76773392
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76355356
87GABAergic synapse_Homo sapiens_hsa047270.75383843
88Regulation of autophagy_Homo sapiens_hsa041400.74714618
89Retinol metabolism_Homo sapiens_hsa008300.72867431
90Cholinergic synapse_Homo sapiens_hsa047250.71034686
91Cardiac muscle contraction_Homo sapiens_hsa042600.70838296
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70536787
93Non-homologous end-joining_Homo sapiens_hsa034500.70173789
94Hematopoietic cell lineage_Homo sapiens_hsa046400.69782218
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69321923
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.66146442
97Histidine metabolism_Homo sapiens_hsa003400.65895670
98Osteoclast differentiation_Homo sapiens_hsa043800.65788152
99Ras signaling pathway_Homo sapiens_hsa040140.65280926
100Dopaminergic synapse_Homo sapiens_hsa047280.65262869
101Sulfur relay system_Homo sapiens_hsa041220.65242962
102Tyrosine metabolism_Homo sapiens_hsa003500.64928362
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64550904
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63403059
105Glutathione metabolism_Homo sapiens_hsa004800.63349617
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63289567
107Purine metabolism_Homo sapiens_hsa002300.62901118
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.62844951
109Pancreatic secretion_Homo sapiens_hsa049720.62534902
110Ovarian steroidogenesis_Homo sapiens_hsa049130.62317569
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62258290
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62043513
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61943263
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61668629
115Gastric acid secretion_Homo sapiens_hsa049710.61348055
116Hedgehog signaling pathway_Homo sapiens_hsa043400.60216839
117RNA degradation_Homo sapiens_hsa030180.59120510
118Phenylalanine metabolism_Homo sapiens_hsa003600.58448026
119Nucleotide excision repair_Homo sapiens_hsa034200.57730534
120Caffeine metabolism_Homo sapiens_hsa002320.57548387
121Arginine and proline metabolism_Homo sapiens_hsa003300.56332363
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56145542
123Fatty acid degradation_Homo sapiens_hsa000710.55794413
124Estrogen signaling pathway_Homo sapiens_hsa049150.55617638
125Basal cell carcinoma_Homo sapiens_hsa052170.55174780
126Systemic lupus erythematosus_Homo sapiens_hsa053220.54050414
127Choline metabolism in cancer_Homo sapiens_hsa052310.53850103
128Herpes simplex infection_Homo sapiens_hsa051680.53600555
129Alcoholism_Homo sapiens_hsa050340.52660405
130MAPK signaling pathway_Homo sapiens_hsa040100.51820788
131Hippo signaling pathway_Homo sapiens_hsa043900.51784379
132Melanoma_Homo sapiens_hsa052180.51620961
133Synaptic vesicle cycle_Homo sapiens_hsa047210.51452172
134Measles_Homo sapiens_hsa051620.51262051
135African trypanosomiasis_Homo sapiens_hsa051430.49238850
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.49109320
137ABC transporters_Homo sapiens_hsa020100.48317654
138Circadian rhythm_Homo sapiens_hsa047100.48010328
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47643395
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47544671
141B cell receptor signaling pathway_Homo sapiens_hsa046620.47451675
142Pyrimidine metabolism_Homo sapiens_hsa002400.46746629
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46687860
144Fatty acid metabolism_Homo sapiens_hsa012120.46558102
145Vibrio cholerae infection_Homo sapiens_hsa051100.42910091
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42229989
147Notch signaling pathway_Homo sapiens_hsa043300.42157689
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.41954347
149Primary immunodeficiency_Homo sapiens_hsa053400.41253904
150Huntingtons disease_Homo sapiens_hsa050160.41223412
151Glycerolipid metabolism_Homo sapiens_hsa005610.40577790
152Selenocompound metabolism_Homo sapiens_hsa004500.40415162
153T cell receptor signaling pathway_Homo sapiens_hsa046600.39568909
154Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39526848
155Gap junction_Homo sapiens_hsa045400.39205984
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37942012
157Long-term depression_Homo sapiens_hsa047300.35298563
158Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33235362

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