FAM218A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)8.30538296
2nucleobase catabolic process (GO:0046113)6.96894331
3gamma-aminobutyric acid transport (GO:0015812)5.44900260
4neuron cell-cell adhesion (GO:0007158)4.78706015
5presynaptic membrane assembly (GO:0097105)4.71262194
6DNA double-strand break processing (GO:0000729)4.43821312
7positive regulation of amino acid transport (GO:0051957)4.40949438
8cell migration in hindbrain (GO:0021535)4.30302267
9protein localization to synapse (GO:0035418)4.22412226
10presynaptic membrane organization (GO:0097090)4.18756809
11vocalization behavior (GO:0071625)4.07191091
12water-soluble vitamin biosynthetic process (GO:0042364)4.06596148
13positive regulation of mitochondrial fission (GO:0090141)3.93524836
14nonmotile primary cilium assembly (GO:0035058)3.93218264
15positive regulation of synapse assembly (GO:0051965)3.73730354
16negative regulation of synaptic transmission, GABAergic (GO:0032229)3.70670993
17cerebral cortex radially oriented cell migration (GO:0021799)3.68910439
18establishment of mitochondrion localization (GO:0051654)3.49374567
19glycosphingolipid biosynthetic process (GO:0006688)3.42482125
20G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.35965638
21positive regulation of dendritic spine morphogenesis (GO:0061003)3.33055725
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31872671
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.31872671
24NADH dehydrogenase complex assembly (GO:0010257)3.31872671
25synapse assembly (GO:0007416)3.31193916
26auditory behavior (GO:0031223)3.26052666
27postsynaptic membrane organization (GO:0001941)3.25180200
28DNA integration (GO:0015074)3.15112209
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.13155476
30limb bud formation (GO:0060174)3.09330704
31ribonucleoprotein complex disassembly (GO:0032988)3.06520332
32olfactory bulb development (GO:0021772)3.05342086
33protein polyglutamylation (GO:0018095)3.04320972
34cullin deneddylation (GO:0010388)3.03724478
35regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.00293871
36protein complex biogenesis (GO:0070271)2.98014413
37regulation of synapse assembly (GO:0051963)2.97391654
38ionotropic glutamate receptor signaling pathway (GO:0035235)2.95947300
39mitochondrial respiratory chain complex assembly (GO:0033108)2.93689292
40glutamate receptor signaling pathway (GO:0007215)2.91476431
41hippocampus development (GO:0021766)2.89221296
42protein deneddylation (GO:0000338)2.88719876
43regulation of telomere maintenance via telomerase (GO:0032210)2.88618999
44retinal ganglion cell axon guidance (GO:0031290)2.86920417
45somite development (GO:0061053)2.80757109
46righting reflex (GO:0060013)2.79616803
47establishment of melanosome localization (GO:0032401)2.76813717
48organelle disassembly (GO:1903008)2.76731703
49positive regulation of amine transport (GO:0051954)2.75186424
50layer formation in cerebral cortex (GO:0021819)2.74232680
51neurotransmitter secretion (GO:0007269)2.72721302
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.70851356
53peptidyl-cysteine modification (GO:0018198)2.70602411
54central nervous system projection neuron axonogenesis (GO:0021952)2.68257095
55calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.67587402
56axonal fasciculation (GO:0007413)2.66702417
57melanosome transport (GO:0032402)2.66195813
58neuron recognition (GO:0008038)2.65171154
59regulation of telomere maintenance (GO:0032204)2.65069701
60sequestering of actin monomers (GO:0042989)2.63128610
61establishment of pigment granule localization (GO:0051905)2.62986060
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.62739610
63dendrite morphogenesis (GO:0048813)2.62082977
64DNA damage response, detection of DNA damage (GO:0042769)2.61941242
65synaptic transmission, glutamatergic (GO:0035249)2.61889890
66negative regulation of JAK-STAT cascade (GO:0046426)2.61692022
67protein insertion into membrane (GO:0051205)2.61678820
68startle response (GO:0001964)2.59505037
69iron-sulfur cluster assembly (GO:0016226)2.58420366
70metallo-sulfur cluster assembly (GO:0031163)2.58420366
71sialylation (GO:0097503)2.58136186
72positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.56789409
73mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.56789409
74regulation of cilium movement (GO:0003352)2.56537740
75retinal cone cell development (GO:0046549)2.56447585
76regulation of cofactor metabolic process (GO:0051193)2.55977325
77regulation of coenzyme metabolic process (GO:0051196)2.55977325
78transmission of nerve impulse (GO:0019226)2.55460277
79regulation of dendritic spine morphogenesis (GO:0061001)2.55282335
80ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.52706578
81de novo posttranslational protein folding (GO:0051084)2.52413253
82pigment granule transport (GO:0051904)2.52222257
83cerebral cortex cell migration (GO:0021795)2.51591914
84negative regulation of response to food (GO:0032096)2.51362048
85negative regulation of appetite (GO:0032099)2.51362048
86intraciliary transport (GO:0042073)2.51113516
87epithelial cilium movement (GO:0003351)2.50486700
88neurofilament cytoskeleton organization (GO:0060052)2.49369110
89microtubule depolymerization (GO:0007019)2.49027737
90aldehyde catabolic process (GO:0046185)2.48898511
91mechanosensory behavior (GO:0007638)2.48420832
92protein localization to peroxisome (GO:0072662)2.48108106
93protein targeting to peroxisome (GO:0006625)2.48108106
94establishment of protein localization to peroxisome (GO:0072663)2.48108106
95regulation of feeding behavior (GO:0060259)2.48075281
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.46552012
97regulation of mitochondrial fission (GO:0090140)2.44383315
98negative regulation of telomere maintenance (GO:0032205)2.44244470
99mannosylation (GO:0097502)2.43816685
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43221006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.60472795
2IGF1R_20145208_ChIP-Seq_DFB_Human3.57591740
3GBX2_23144817_ChIP-Seq_PC3_Human3.41288421
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.06507710
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85021378
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82477799
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72025380
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63373276
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.63293851
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51562018
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49689726
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.47358488
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.40730016
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.39480966
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.34913942
16TAF15_26573619_Chip-Seq_HEK293_Human2.30188519
17FUS_26573619_Chip-Seq_HEK293_Human2.28410310
18EZH2_22144423_ChIP-Seq_EOC_Human2.18910220
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12913294
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97989123
21VDR_22108803_ChIP-Seq_LS180_Human1.97128125
22RNF2_27304074_Chip-Seq_NSC_Mouse1.88126444
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85497947
24EWS_26573619_Chip-Seq_HEK293_Human1.81699606
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.80394302
26REST_21632747_ChIP-Seq_MESCs_Mouse1.80347239
27P300_19829295_ChIP-Seq_ESCs_Human1.80106915
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79701175
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65622124
30ELK1_19687146_ChIP-ChIP_HELA_Human1.65251537
31CBP_20019798_ChIP-Seq_JUKART_Human1.58069365
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58069365
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.56388933
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.53670906
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53593483
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51549390
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49932211
38VDR_23849224_ChIP-Seq_CD4+_Human1.48894158
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47273482
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47059925
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44011868
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41913849
43SMAD4_21799915_ChIP-Seq_A2780_Human1.38982307
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36424066
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36248525
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34830470
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34347267
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33737944
49ER_23166858_ChIP-Seq_MCF-7_Human1.33113543
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30883807
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.29141623
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.28286520
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27471836
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27414706
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26226797
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26052726
57IRF1_19129219_ChIP-ChIP_H3396_Human1.25625102
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25182909
59TP53_22573176_ChIP-Seq_HFKS_Human1.25033139
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24139645
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.23792729
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23552072
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22203617
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.21356788
65AR_25329375_ChIP-Seq_VCAP_Human1.18737368
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.18006795
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17848026
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15781794
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15764797
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14700394
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.13892348
72AR_21572438_ChIP-Seq_LNCaP_Human1.13566530
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.13455457
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12956367
75MYC_18940864_ChIP-ChIP_HL60_Human1.10747178
76GABP_19822575_ChIP-Seq_HepG2_Human1.10534624
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10261593
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10261593
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09297685
80STAT3_23295773_ChIP-Seq_U87_Human1.09294616
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09192026
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.08352969
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07453595
84JUN_21703547_ChIP-Seq_K562_Human1.04977498
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.02703590
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02684297
87RUNX2_22187159_ChIP-Seq_PCA_Human1.01467767
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.00294416
89YY1_21170310_ChIP-Seq_MESCs_Mouse0.99978604
90BCAT_22108803_ChIP-Seq_LS180_Human0.97591726
91TCF4_23295773_ChIP-Seq_U87_Human0.97388379
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96570583
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96457561
94DCP1A_22483619_ChIP-Seq_HELA_Human0.96054445
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.94400773
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93937555
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.92738191
98JARID2_20064375_ChIP-Seq_MESCs_Mouse0.92097510
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89807786
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89203820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.92359315
2MP0004859_abnormal_synaptic_plasticity3.15999208
3MP0005499_abnormal_olfactory_system3.12351069
4MP0005394_taste/olfaction_phenotype3.12351069
5MP0002822_catalepsy2.94228862
6MP0004270_analgesia2.93428939
7MP0001986_abnormal_taste_sensitivity2.82594951
8MP0008789_abnormal_olfactory_epithelium2.82293680
9MP0001984_abnormal_olfaction2.33537991
10MP0003122_maternal_imprinting2.27604256
11MP0001968_abnormal_touch/_nociception2.26501931
12MP0002735_abnormal_chemical_nociception2.23566314
13MP0000778_abnormal_nervous_system2.19777527
14MP0002736_abnormal_nociception_after2.18996553
15MP0005423_abnormal_somatic_nervous2.13964606
16MP0003635_abnormal_synaptic_transmissio2.09401035
17MP0006276_abnormal_autonomic_nervous2.05370397
18MP0002734_abnormal_mechanical_nocicepti2.00867778
19MP0006292_abnormal_olfactory_placode1.98950430
20MP0003880_abnormal_central_pattern1.98791694
21MP0008877_abnormal_DNA_methylation1.97913528
22MP0009745_abnormal_behavioral_response1.97551625
23MP0009046_muscle_twitch1.82533026
24MP0002063_abnormal_learning/memory/cond1.81839661
25MP0001188_hyperpigmentation1.79257993
26MP0002102_abnormal_ear_morphology1.71389759
27MP0004924_abnormal_behavior1.71379224
28MP0005386_behavior/neurological_phenoty1.71379224
29MP0005645_abnormal_hypothalamus_physiol1.70646220
30MP0001486_abnormal_startle_reflex1.65856084
31MP0002572_abnormal_emotion/affect_behav1.63638343
32MP0003121_genomic_imprinting1.63203402
33MP0002272_abnormal_nervous_system1.61984296
34MP0002653_abnormal_ependyma_morphology1.59920822
35MP0008995_early_reproductive_senescence1.56302419
36MP0002234_abnormal_pharynx_morphology1.55306956
37MP0002184_abnormal_innervation1.52293378
38MP0004811_abnormal_neuron_physiology1.51644917
39MP0002751_abnormal_autonomic_nervous1.50681089
40MP0002733_abnormal_thermal_nociception1.46690802
41MP0001970_abnormal_pain_threshold1.44769720
42MP0002557_abnormal_social/conspecific_i1.44212889
43MP0002067_abnormal_sensory_capabilities1.43725245
44MP0003787_abnormal_imprinting1.43539392
45MP0001905_abnormal_dopamine_level1.39853286
46MP0002064_seizures1.37026708
47MP0000955_abnormal_spinal_cord1.35254004
48MP0005551_abnormal_eye_electrophysiolog1.32199582
49MP0005187_abnormal_penis_morphology1.32161205
50MP0006072_abnormal_retinal_apoptosis1.29567613
51MP0005253_abnormal_eye_physiology1.29489509
52MP0002837_dystrophic_cardiac_calcinosis1.28680401
53MP0000049_abnormal_middle_ear1.28267918
54MP0002882_abnormal_neuron_morphology1.26583414
55MP0000631_abnormal_neuroendocrine_gland1.26208699
56MP0006035_abnormal_mitochondrial_morpho1.24479028
57MP0008058_abnormal_DNA_repair1.21990489
58MP0003221_abnormal_cardiomyocyte_apopto1.19385098
59MP0004142_abnormal_muscle_tone1.16683708
60MP0003119_abnormal_digestive_system1.12334030
61MP0003011_delayed_dark_adaptation1.11425937
62MP0000569_abnormal_digit_pigmentation1.09799429
63MP0002638_abnormal_pupillary_reflex1.07632435
64MP0003938_abnormal_ear_development1.04160466
65MP0002752_abnormal_somatic_nervous1.04144824
66MP0002909_abnormal_adrenal_gland1.00726872
67MP0002152_abnormal_brain_morphology0.99551220
68MP0003937_abnormal_limbs/digits/tail_de0.98567299
69MP0002066_abnormal_motor_capabilities/c0.98022614
70MP0004133_heterotaxia0.96287077
71MP0003195_calcinosis0.95723829
72MP0002160_abnormal_reproductive_system0.95066323
73MP0003861_abnormal_nervous_system0.94415367
74MP0003137_abnormal_impulse_conducting0.93943967
75MP0001177_atelectasis0.92592713
76MP0005623_abnormal_meninges_morphology0.92587194
77MP0002069_abnormal_eating/drinking_beha0.92195410
78MP0000013_abnormal_adipose_tissue0.88840038
79MP0003718_maternal_effect0.88315138
80MP0000372_irregular_coat_pigmentation0.87044755
81MP0002233_abnormal_nose_morphology0.86172200
82MP0000647_abnormal_sebaceous_gland0.85955858
83MP0004885_abnormal_endolymph0.85908164
84MP0000026_abnormal_inner_ear0.85710286
85MP0002938_white_spotting0.83863107
86MP0005084_abnormal_gallbladder_morpholo0.83672588
87MP0002229_neurodegeneration0.82030030
88MP0001286_abnormal_eye_development0.80980104
89MP0008569_lethality_at_weaning0.77958705
90MP0005248_abnormal_Harderian_gland0.76058349
91MP0001299_abnormal_eye_distance/0.75158074
92MP0004085_abnormal_heartbeat0.74783209
93MP0005195_abnormal_posterior_eye0.73795047
94MP0003698_abnormal_male_reproductive0.73697508
95MP0004742_abnormal_vestibular_system0.73442269
96MP0000358_abnormal_cell_content/0.72209244
97MP0001293_anophthalmia0.71576693
98MP0009697_abnormal_copulation0.67657904
99MP0003890_abnormal_embryonic-extraembry0.66891314
100MP0001502_abnormal_circadian_rhythm0.66622523

Predicted human phenotypes

RankGene SetZ-score
1Gait imbalance (HP:0002141)4.59118407
2Medial flaring of the eyebrow (HP:0010747)4.50861978
3Congenital primary aphakia (HP:0007707)4.27369235
4Hyperventilation (HP:0002883)3.75097149
5Nephrogenic diabetes insipidus (HP:0009806)3.72527448
6Pancreatic cysts (HP:0001737)3.55996569
7True hermaphroditism (HP:0010459)3.44189784
8Vaginal atresia (HP:0000148)3.31827297
9Pancreatic fibrosis (HP:0100732)3.29987255
10Poor coordination (HP:0002370)3.27521415
11Drooling (HP:0002307)3.26130082
12Genital tract atresia (HP:0001827)3.26038171
13Excessive salivation (HP:0003781)2.98057117
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.91735782
15Absent/shortened dynein arms (HP:0200106)2.91735782
16Lissencephaly (HP:0001339)2.89890182
17Cerebellar dysplasia (HP:0007033)2.86129613
18Absent speech (HP:0001344)2.85254094
19Nephronophthisis (HP:0000090)2.84812797
20Specific learning disability (HP:0001328)2.82503872
21Cortical dysplasia (HP:0002539)2.70681778
22Methylmalonic acidemia (HP:0002912)2.65734388
23Acute necrotizing encephalopathy (HP:0006965)2.60986694
24Acute encephalopathy (HP:0006846)2.56563813
25Abnormality of midbrain morphology (HP:0002418)2.56429315
26Molar tooth sign on MRI (HP:0002419)2.56429315
27Abnormality of the labia minora (HP:0012880)2.55251715
28Pachygyria (HP:0001302)2.50830229
29Hepatocellular necrosis (HP:0001404)2.47807597
30Type II lissencephaly (HP:0007260)2.46559200
31Abnormal mitochondria in muscle tissue (HP:0008316)2.40994824
32Polyphagia (HP:0002591)2.39488898
33Shoulder girdle muscle weakness (HP:0003547)2.38985554
34Amyotrophic lateral sclerosis (HP:0007354)2.37744429
35Myokymia (HP:0002411)2.37184002
36Atonic seizures (HP:0010819)2.35569646
37Retinal dysplasia (HP:0007973)2.33108030
38Decreased testicular size (HP:0008734)2.32835474
39Hypoplasia of the brainstem (HP:0002365)2.31668284
40Aplasia/Hypoplasia of the brainstem (HP:0007362)2.31668284
41Chronic hepatic failure (HP:0100626)2.31452896
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.30940890
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30940890
44Broad foot (HP:0001769)2.28996349
45Abnormal respiratory motile cilium morphology (HP:0005938)2.27857680
46Abnormal respiratory epithelium morphology (HP:0012253)2.27857680
47Aplasia/Hypoplasia of the lens (HP:0008063)2.27052329
48Mitochondrial inheritance (HP:0001427)2.26187397
49Broad-based gait (HP:0002136)2.25749076
50Abnormality of the corticospinal tract (HP:0002492)2.23657943
51Abnormal ciliary motility (HP:0012262)2.22866756
52Microvesicular hepatic steatosis (HP:0001414)2.20727668
53Hyperglycinemia (HP:0002154)2.20445329
54Postaxial hand polydactyly (HP:0001162)2.19026547
55Abnormality of the renal medulla (HP:0100957)2.17856206
56Urinary urgency (HP:0000012)2.17347753
57Pendular nystagmus (HP:0012043)2.16039358
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.15050304
59Muscular hypotonia of the trunk (HP:0008936)2.13860294
60Cystic liver disease (HP:0006706)2.13116111
61Increased CSF lactate (HP:0002490)2.12987573
62Tubulointerstitial nephritis (HP:0001970)2.12775672
63Progressive macrocephaly (HP:0004481)2.12714704
64Hepatic necrosis (HP:0002605)2.11819589
65Abnormality of the hip-girdle musculature (HP:0001445)2.09517536
66Abnormality of the musculature of the pelvis (HP:0001469)2.09517536
67Occipital encephalocele (HP:0002085)2.04051151
68Atrophy/Degeneration involving motor neurons (HP:0007373)2.03704643
69Agitation (HP:0000713)2.01527255
70Fibular aplasia (HP:0002990)2.00016939
71Sclerocornea (HP:0000647)1.98830204
72Epileptic encephalopathy (HP:0200134)1.98384118
73Anencephaly (HP:0002323)1.97367531
74Split foot (HP:0001839)1.96966274
75Failure to thrive in infancy (HP:0001531)1.96048079
76Morphological abnormality of the pyramidal tract (HP:0002062)1.94971147
77Optic nerve hypoplasia (HP:0000609)1.94671500
78Limb dystonia (HP:0002451)1.93994006
79Bifid tongue (HP:0010297)1.92080769
80Focal seizures (HP:0007359)1.88792500
81Oculomotor apraxia (HP:0000657)1.87149196
82Aplasia/hypoplasia of the uterus (HP:0008684)1.86446814
83Left ventricular hypertrophy (HP:0001712)1.84044908
84Hypsarrhythmia (HP:0002521)1.82783914
85Rimmed vacuoles (HP:0003805)1.81231946
86Abnormal respiratory motile cilium physiology (HP:0012261)1.80829145
87Abnormal hair whorl (HP:0010721)1.79245871
88Dialeptic seizures (HP:0011146)1.79094398
89Short foot (HP:0001773)1.78585928
90Methylmalonic aciduria (HP:0012120)1.78300463
91Retinitis pigmentosa (HP:0000510)1.77998426
92Pelvic girdle muscle weakness (HP:0003749)1.77211763
93Broad alveolar ridges (HP:0000187)1.77196216
94Abolished electroretinogram (ERG) (HP:0000550)1.76872707
95Esotropia (HP:0000565)1.76735264
96Septo-optic dysplasia (HP:0100842)1.76587377
97Micropenis (HP:0000054)1.75810012
98Polymicrogyria (HP:0002126)1.75485000
99Astigmatism (HP:0000483)1.75371438
100Abnormal biliary tract physiology (HP:0012439)1.74239438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.21982851
2MAP2K73.92342780
3MAP3K43.89346195
4BCR3.56012707
5CASK3.34966723
6TRIM283.06893393
7MAPK132.80002828
8DYRK22.51230505
9WNK32.33555800
10ERBB32.23273797
11MAP4K22.14523626
12SRPK12.13625310
13DYRK31.91089786
14DAPK21.83088592
15PBK1.79425224
16CSNK1G31.69170936
17SIK21.63577976
18CSNK1G21.58407370
19CSNK1A1L1.55374210
20STK161.54010713
21CSNK1G11.42108633
22BCKDK1.37231317
23MAP2K41.37169837
24TSSK61.35299395
25UHMK11.33032103
26CCNB11.27226501
27EPHA41.22789358
28CDK191.20893982
29EPHA31.19609703
30FLT31.18923888
31INSRR1.16362550
32IRAK21.15529001
33PRKCG1.14429279
34PAK31.11751837
35IRAK11.07196240
36PRKCE1.00886857
37CAMKK20.99822555
38PKN20.98666672
39NTRK20.95397079
40VRK10.95393617
41BMPR1B0.91752920
42CDC70.89314288
43MINK10.86600063
44DAPK10.82003512
45DYRK1A0.80063224
46CDK50.78010029
47CAMK2B0.75979154
48SGK2230.75917525
49SGK4940.75917525
50NTRK30.75311857
51PKN10.73688282
52KSR10.73250470
53RAF10.73193431
54CDK140.72249423
55MAPK150.71989549
56MKNK10.69989212
57MKNK20.69264332
58GRK10.65494049
59PAK60.64785688
60DYRK1B0.64067284
61NEK10.63096513
62ADRBK20.63010616
63LIMK10.61927444
64TESK10.61393876
65ZAK0.61366967
66FRK0.61010862
67CDK180.59898112
68CAMK2A0.59180276
69PLK30.56986520
70ARAF0.55446709
71CDK150.53766103
72BRD40.53613053
73CAMK2G0.53247963
74CDK11A0.53115879
75PHKG10.52479291
76PHKG20.52479291
77FER0.51812020
78PLK20.48191524
79PRKCZ0.46838558
80RPS6KA40.45844992
81MUSK0.45588617
82TNIK0.43413339
83OXSR10.39954691
84PIM20.38878260
85PRKACB0.38868859
86CSNK1A10.38095884
87PLK10.37718385
88NME10.37372134
89BRSK20.36708584
90PRKACA0.34757045
91MAP3K60.34593788
92AURKA0.34343739
93MAP3K50.33545817
94GRK70.32582598
95CAMK2D0.30244105
96YES10.29737122
97ADRBK10.29345986
98PDK20.29265863
99EPHB20.29208450
100TESK20.29052399

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62780424
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.98347794
3Oxidative phosphorylation_Homo sapiens_hsa001902.52432132
4GABAergic synapse_Homo sapiens_hsa047272.51704684
5Protein export_Homo sapiens_hsa030602.47855371
6Sulfur metabolism_Homo sapiens_hsa009202.43059867
7Parkinsons disease_Homo sapiens_hsa050122.33914905
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31230619
9Phototransduction_Homo sapiens_hsa047442.19216326
10Basal transcription factors_Homo sapiens_hsa030222.14508528
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02823110
12RNA polymerase_Homo sapiens_hsa030201.87842635
13Synaptic vesicle cycle_Homo sapiens_hsa047211.84852114
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75850920
15Regulation of autophagy_Homo sapiens_hsa041401.73079139
16Morphine addiction_Homo sapiens_hsa050321.70298505
17RNA degradation_Homo sapiens_hsa030181.58312493
18Glutamatergic synapse_Homo sapiens_hsa047241.58071451
19Circadian entrainment_Homo sapiens_hsa047131.57249473
20Dopaminergic synapse_Homo sapiens_hsa047281.55745916
21Huntingtons disease_Homo sapiens_hsa050161.54999190
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53148337
23Taste transduction_Homo sapiens_hsa047421.47532988
24Steroid biosynthesis_Homo sapiens_hsa001001.40963491
25Alzheimers disease_Homo sapiens_hsa050101.34214035
26Cocaine addiction_Homo sapiens_hsa050301.29677802
27Fanconi anemia pathway_Homo sapiens_hsa034601.28344303
28Collecting duct acid secretion_Homo sapiens_hsa049661.27801572
29Butanoate metabolism_Homo sapiens_hsa006501.25137125
30Cardiac muscle contraction_Homo sapiens_hsa042601.23373394
31Selenocompound metabolism_Homo sapiens_hsa004501.21940197
32Axon guidance_Homo sapiens_hsa043601.19966129
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15447539
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12253492
35mRNA surveillance pathway_Homo sapiens_hsa030151.10975304
36Peroxisome_Homo sapiens_hsa041461.08643385
37Proteasome_Homo sapiens_hsa030501.07120761
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06565443
39Oocyte meiosis_Homo sapiens_hsa041141.06516513
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06445596
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06394648
42Amphetamine addiction_Homo sapiens_hsa050311.06172780
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05931717
44Sulfur relay system_Homo sapiens_hsa041221.05877260
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04224911
46Vibrio cholerae infection_Homo sapiens_hsa051101.04137469
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03454472
48Ether lipid metabolism_Homo sapiens_hsa005651.00584929
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99395290
50Spliceosome_Homo sapiens_hsa030400.98799256
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95584086
52Circadian rhythm_Homo sapiens_hsa047100.95369471
53Serotonergic synapse_Homo sapiens_hsa047260.93616541
54Long-term depression_Homo sapiens_hsa047300.93548772
55Biosynthesis of amino acids_Homo sapiens_hsa012300.90249167
56Purine metabolism_Homo sapiens_hsa002300.90242570
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89323485
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86344559
59Olfactory transduction_Homo sapiens_hsa047400.85424713
60Hedgehog signaling pathway_Homo sapiens_hsa043400.83735243
61Propanoate metabolism_Homo sapiens_hsa006400.83502984
62RNA transport_Homo sapiens_hsa030130.82346109
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81724403
64Base excision repair_Homo sapiens_hsa034100.80827762
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80447349
66Non-homologous end-joining_Homo sapiens_hsa034500.78521171
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75888809
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.75642383
69Fatty acid elongation_Homo sapiens_hsa000620.75318898
70Alcoholism_Homo sapiens_hsa050340.74732603
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74243119
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73129443
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70363153
74Homologous recombination_Homo sapiens_hsa034400.68931454
75Pyrimidine metabolism_Homo sapiens_hsa002400.68317512
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.66069813
77Metabolic pathways_Homo sapiens_hsa011000.65446023
78Insulin secretion_Homo sapiens_hsa049110.62513366
79Gap junction_Homo sapiens_hsa045400.62011155
80Nucleotide excision repair_Homo sapiens_hsa034200.58566152
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57659679
82Hippo signaling pathway_Homo sapiens_hsa043900.57425226
83Tight junction_Homo sapiens_hsa045300.52585693
84Linoleic acid metabolism_Homo sapiens_hsa005910.51914048
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49921230
86Cholinergic synapse_Homo sapiens_hsa047250.49244338
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44988414
88Fructose and mannose metabolism_Homo sapiens_hsa000510.43188933
89Carbon metabolism_Homo sapiens_hsa012000.41385714
90Glutathione metabolism_Homo sapiens_hsa004800.41172979
91Arginine and proline metabolism_Homo sapiens_hsa003300.39250530
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.39062093
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37394824
94beta-Alanine metabolism_Homo sapiens_hsa004100.37349437
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.35727935
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34363283
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.33755566
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32605568
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32145414
100Mismatch repair_Homo sapiens_hsa034300.30127545

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