FAM214A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.18390990
2L-phenylalanine catabolic process (GO:0006559)6.18390990
3L-phenylalanine metabolic process (GO:0006558)5.53436004
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.53436004
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.07212154
6aromatic amino acid family catabolic process (GO:0009074)5.02149531
7piRNA metabolic process (GO:0034587)4.80047653
8fatty acid elongation (GO:0030497)4.66913982
9alpha-linolenic acid metabolic process (GO:0036109)4.44473996
10bile acid biosynthetic process (GO:0006699)4.38256518
11cysteine metabolic process (GO:0006534)4.07168120
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.06585484
13central nervous system myelination (GO:0022010)4.03906417
14axon ensheathment in central nervous system (GO:0032291)4.03906417
15tryptophan catabolic process (GO:0006569)4.01248074
16indole-containing compound catabolic process (GO:0042436)4.01248074
17indolalkylamine catabolic process (GO:0046218)4.01248074
18histone H3-K4 trimethylation (GO:0080182)3.98835815
19glyoxylate metabolic process (GO:0046487)3.89051076
20tryptophan metabolic process (GO:0006568)3.80565790
21kynurenine metabolic process (GO:0070189)3.80161996
22complement activation, alternative pathway (GO:0006957)3.79361380
23bile acid metabolic process (GO:0008206)3.78250844
24histone H3-K36 demethylation (GO:0070544)3.75150310
25tyrosine metabolic process (GO:0006570)3.74035398
26short-chain fatty acid metabolic process (GO:0046459)3.73410895
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.72965666
28DNA methylation involved in gamete generation (GO:0043046)3.72923119
29fatty-acyl-CoA biosynthetic process (GO:0046949)3.67828896
30sulfur amino acid catabolic process (GO:0000098)3.65993976
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.65026896
32acetyl-CoA metabolic process (GO:0006084)3.63128412
33cellular ketone body metabolic process (GO:0046950)3.61089102
34very long-chain fatty acid metabolic process (GO:0000038)3.58594392
35long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.56825051
36urea metabolic process (GO:0019627)3.54403672
37urea cycle (GO:0000050)3.54403672
38myelination (GO:0042552)3.52464433
39ensheathment of neurons (GO:0007272)3.51878068
40axon ensheathment (GO:0008366)3.51878068
41nitrogen cycle metabolic process (GO:0071941)3.49233171
42regulation of protein activation cascade (GO:2000257)3.47001037
43aromatic amino acid family metabolic process (GO:0009072)3.46405741
44regulation of triglyceride catabolic process (GO:0010896)3.45445138
45plasma lipoprotein particle clearance (GO:0034381)3.45006727
46high-density lipoprotein particle remodeling (GO:0034375)3.44006422
47acyl-CoA biosynthetic process (GO:0071616)3.40754648
48thioester biosynthetic process (GO:0035384)3.40754648
49regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.40542869
50positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.40542869
51negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.37623175
52negative regulation of T-helper cell differentiation (GO:0045623)3.37623175
53peptidyl-glutamic acid carboxylation (GO:0017187)3.37272109
54protein carboxylation (GO:0018214)3.37272109
55histone H3-K9 demethylation (GO:0033169)3.36744600
56glycerophospholipid catabolic process (GO:0046475)3.33715065
57negative regulation of fibrinolysis (GO:0051918)3.33664011
58regulation of fibrinolysis (GO:0051917)3.31295977
59establishment of protein localization to Golgi (GO:0072600)3.30389597
60Golgi to endosome transport (GO:0006895)3.29676551
61keratinocyte development (GO:0003334)3.27514635
62regulation of complement activation (GO:0030449)3.26368937
63coenzyme catabolic process (GO:0009109)3.22926735
64male meiosis (GO:0007140)3.22210069
65glutamate metabolic process (GO:0006536)3.21999559
66protein targeting to Golgi (GO:0000042)3.20996763
67alpha-amino acid catabolic process (GO:1901606)3.20923677
68fatty-acyl-CoA metabolic process (GO:0035337)3.20189415
69triglyceride homeostasis (GO:0070328)3.19534620
70acylglycerol homeostasis (GO:0055090)3.19534620
71homocysteine metabolic process (GO:0050667)3.19136580
72ethanol oxidation (GO:0006069)3.19018118
73protein K11-linked deubiquitination (GO:0035871)3.18959516
74cilium or flagellum-dependent cell motility (GO:0001539)3.16998171
75biotin metabolic process (GO:0006768)3.16562036
76regulation of bile acid biosynthetic process (GO:0070857)3.15468609
77synapsis (GO:0007129)3.15247502
78retrograde transport, vesicle recycling within Golgi (GO:0000301)3.15118750
79negative regulation of cAMP-mediated signaling (GO:0043951)3.14894718
80positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.13959577
81regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.13959577
82peptidyl-lysine trimethylation (GO:0018023)3.13048565
83fatty acid beta-oxidation (GO:0006635)3.12690686
84ketone body metabolic process (GO:1902224)3.10199128
85reverse cholesterol transport (GO:0043691)3.09192517
86macroautophagy (GO:0016236)3.08529048
87cholesterol efflux (GO:0033344)3.06291441
88cellular amino acid catabolic process (GO:0009063)3.02769785
89negative regulation of neurotransmitter secretion (GO:0046929)3.02505479
90amino-acid betaine metabolic process (GO:0006577)3.02401191
91fatty acid oxidation (GO:0019395)3.01747916
92indolalkylamine metabolic process (GO:0006586)3.01408807
93fatty acid catabolic process (GO:0009062)3.00532777
94serine family amino acid catabolic process (GO:0009071)2.98574168
95adhesion of symbiont to host cell (GO:0044650)2.98020713
96virion attachment to host cell (GO:0019062)2.98020713
97negative regulation of lipase activity (GO:0060192)2.97950528
98histone lysine demethylation (GO:0070076)2.97911014
99monocarboxylic acid catabolic process (GO:0072329)2.97759148
100creatine metabolic process (GO:0006600)2.97629924
101lysine catabolic process (GO:0006554)2.97196477
102lysine metabolic process (GO:0006553)2.97196477
103histone demethylation (GO:0016577)2.97098432
104regulation of germinal center formation (GO:0002634)2.96705553
105cellular response to ethanol (GO:0071361)2.96286934
106lipid oxidation (GO:0034440)2.95929968
107regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.95879782
108protein-lipid complex remodeling (GO:0034368)2.94317730
109macromolecular complex remodeling (GO:0034367)2.94317730
110plasma lipoprotein particle remodeling (GO:0034369)2.94317730
111long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.94308049
112acyl-CoA metabolic process (GO:0006637)2.94292603
113thioester metabolic process (GO:0035383)2.94292603
114axoneme assembly (GO:0035082)2.93946921
115regulation of clathrin-mediated endocytosis (GO:2000369)2.92759928
116opsonization (GO:0008228)2.89819522
117regulation of protein glycosylation (GO:0060049)2.89786376
118brain morphogenesis (GO:0048854)2.88146605
119complement activation, classical pathway (GO:0006958)2.87519346
120cholesterol biosynthetic process (GO:0006695)2.87167211
121male meiosis I (GO:0007141)2.87042625
122positive regulation of fatty acid beta-oxidation (GO:0032000)2.83864104
123interkinetic nuclear migration (GO:0022027)2.83804972
124very-low-density lipoprotein particle assembly (GO:0034379)2.83449783
125organic acid catabolic process (GO:0016054)2.82914924
126carboxylic acid catabolic process (GO:0046395)2.82914924
127histone H3-K9 modification (GO:0061647)2.81678985
128complement activation (GO:0006956)2.81276927
129cellular biogenic amine catabolic process (GO:0042402)2.80429237
130amine catabolic process (GO:0009310)2.80429237
131regulation of cholesterol esterification (GO:0010872)2.79453109
132negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.78967563
133early endosome to late endosome transport (GO:0045022)2.78518655
134retinal cone cell development (GO:0046549)2.78034494
135regulation of cholesterol metabolic process (GO:0090181)2.77617187
136epithelial cilium movement (GO:0003351)2.75969738
137peptidyl-tyrosine autophosphorylation (GO:0038083)2.75675205
138aspartate family amino acid catabolic process (GO:0009068)2.75309792
139cellular glucuronidation (GO:0052695)2.74414086
140histone H3-K9 methylation (GO:0051567)2.73712415
141adhesion of symbiont to host (GO:0044406)2.72194246
142glycerolipid catabolic process (GO:0046503)2.70383727
143protein localization to Golgi apparatus (GO:0034067)2.70240267
144T-helper cell differentiation (GO:0042093)2.68888238
145CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.68888238
146regulation of meiosis I (GO:0060631)2.68204362
147protein dealkylation (GO:0008214)2.67547872
148protein demethylation (GO:0006482)2.67547872
149histone H3-K4 methylation (GO:0051568)2.66234682
150cilium movement (GO:0003341)2.62059571
151multicellular organism reproduction (GO:0032504)2.60846714
152intestinal epithelial cell development (GO:0060576)2.57456677
153regulation of acrosome reaction (GO:0060046)2.57241833
154positive regulation of mRNA catabolic process (GO:0061014)2.56475048
155relaxation of smooth muscle (GO:0044557)2.53847886
156regulation of female receptivity (GO:0045924)2.52284310
157growth hormone receptor signaling pathway (GO:0060396)2.51027805
158synaptonemal complex organization (GO:0070193)2.48974157
159B cell receptor signaling pathway (GO:0050853)2.48643472
160protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.45861916
161gene silencing by RNA (GO:0031047)2.45105731
162neural tube formation (GO:0001841)2.43801316
163interleukin-6-mediated signaling pathway (GO:0070102)2.43780065
164chromosome organization involved in meiosis (GO:0070192)2.40083767
165peptidyl-lysine methylation (GO:0018022)2.39685292
166histone lysine methylation (GO:0034968)2.39144463
167T cell differentiation involved in immune response (GO:0002292)2.38324099
168alpha-beta T cell differentiation involved in immune response (GO:0002293)2.38324099
169alpha-beta T cell activation involved in immune response (GO:0002287)2.38324099
170synaptonemal complex assembly (GO:0007130)2.34343782
171positive regulation of mRNA 3-end processing (GO:0031442)2.32201720
172CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.32150616
173intra-Golgi vesicle-mediated transport (GO:0006891)2.31365672
174detection of light stimulus involved in sensory perception (GO:0050962)2.31283538
175detection of light stimulus involved in visual perception (GO:0050908)2.31283538
176negative regulation of alpha-beta T cell differentiation (GO:0046639)2.30955564
177oocyte development (GO:0048599)2.30811553
178Rap protein signal transduction (GO:0032486)2.30482323
179positive regulation of granulocyte differentiation (GO:0030854)2.30407716
180acrosome assembly (GO:0001675)2.27770960
181regulation of protein polyubiquitination (GO:1902914)2.26432164
182cytoplasmic mRNA processing body assembly (GO:0033962)2.25424406
183relaxation of cardiac muscle (GO:0055119)2.22583813
184regulation of gamma-delta T cell differentiation (GO:0045586)2.22509655
185tachykinin receptor signaling pathway (GO:0007217)2.20782726
186cellular response to growth hormone stimulus (GO:0071378)2.19226047
187negative regulation of JUN kinase activity (GO:0043508)2.18854507
188sister chromatid cohesion (GO:0007062)2.16542624
189cell wall macromolecule metabolic process (GO:0044036)2.15010653
190negative regulation of complement activation (GO:0045916)2.14432518
191positive regulation of glycolytic process (GO:0045821)2.13814299
192regulation of mRNA 3-end processing (GO:0031440)2.10884428
193monoubiquitinated protein deubiquitination (GO:0035520)2.10568286
194smooth muscle tissue development (GO:0048745)2.10171594
195negative regulation of neurotransmitter transport (GO:0051589)2.09804044
196prostate gland growth (GO:0060736)2.07865587
197N-terminal protein amino acid acetylation (GO:0006474)2.06675705
198RNA destabilization (GO:0050779)2.02708345
199endosome to lysosome transport (GO:0008333)2.01084604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.69774598
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.25015265
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.75702752
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.41809496
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.12256968
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11580738
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.79812274
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.72237301
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.50816862
10GBX2_23144817_ChIP-Seq_PC3_Human2.50497275
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50124155
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.45147126
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.36136462
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07654536
15IGF1R_20145208_ChIP-Seq_DFB_Human1.87246301
16VDR_22108803_ChIP-Seq_LS180_Human1.83002744
17TAF15_26573619_Chip-Seq_HEK293_Human1.80987843
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.75813177
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72771995
20FOXM1_26456572_ChIP-Seq_MCF-7_Human1.67262159
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.63426179
22DROSHA_22980978_ChIP-Seq_HELA_Human1.59052767
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58810874
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57689511
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55763151
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.54665768
27ZNF274_21170338_ChIP-Seq_K562_Hela1.52751948
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50288116
29RUNX_20019798_ChIP-Seq_JUKART_Human1.49679912
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49133240
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44256389
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43507915
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.41374910
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41014783
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40373397
36HTT_18923047_ChIP-ChIP_STHdh_Human1.40222753
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35184254
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34867149
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34768413
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33321261
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32558130
42CDX2_22108803_ChIP-Seq_LS180_Human1.30654523
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.29541123
44AR_25329375_ChIP-Seq_VCAP_Human1.29038590
45FUS_26573619_Chip-Seq_HEK293_Human1.28492522
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27816973
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27816973
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26904337
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26715978
50CBP_20019798_ChIP-Seq_JUKART_Human1.26715978
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25453137
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25087608
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23760634
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23703301
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.23644346
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23183613
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.22773397
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21260789
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20966865
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.20659847
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.20050320
62ER_23166858_ChIP-Seq_MCF-7_Human1.19670998
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.19209493
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18327334
65TCF4_22108803_ChIP-Seq_LS180_Human1.17758850
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15943177
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15547308
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15468576
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14450194
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14450194
71P53_22387025_ChIP-Seq_ESCs_Mouse1.13214295
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13089674
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13043073
74RXR_22108803_ChIP-Seq_LS180_Human1.12931798
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12260035
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.12004238
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11490884
78RUNX2_22187159_ChIP-Seq_PCA_Human1.11440600
79AR_21572438_ChIP-Seq_LNCaP_Human1.11282174
80FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.10777101
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10691613
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10563829
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10451393
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.09745390
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09632928
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.09594729
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09243647
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.08627675
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08313011
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07060197
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07033534
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.05823902
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05780412
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05176718
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04568305
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04568305
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04156762
98STAT3_23295773_ChIP-Seq_U87_Human1.03333499
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.02763949
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02632978
101TP63_23658742_ChIP-Seq_EP156T_Human1.01920626
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01749024
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.01310696
104CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01161781
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01064897
106VDR_24787735_ChIP-Seq_THP-1_Human1.01016784
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99886066
108PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99789244
109TP53_16413492_ChIP-PET_HCT116_Human0.99566583
110STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99350865
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98584814
112OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98157895
113SMRT_27268052_Chip-Seq_Bcells_Human0.97830953
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.97810558
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96366390
116FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96166149
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95321494
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93355953
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.92526436
120AHR_22903824_ChIP-Seq_MCF-7_Human0.89932838
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.89577343
122SMAD4_21799915_ChIP-Seq_A2780_Human0.89288929
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89108910
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.88408346
125RARB_27405468_Chip-Seq_BRAIN_Mouse0.88375680
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88182499
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87782874
128SOX2_21211035_ChIP-Seq_LN229_Gbm0.87706781
129TCF4_23295773_ChIP-Seq_U87_Human0.87643327
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87278860
131RNF2_27304074_Chip-Seq_ESCs_Mouse0.87229472
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.86747120
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86079421
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86056356
135P300_19829295_ChIP-Seq_ESCs_Human0.85923928
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.85886380
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84767818
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82952822
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82274547
140WT1_19549856_ChIP-ChIP_CCG9911_Human0.81927229
141REST_21632747_ChIP-Seq_MESCs_Mouse0.81878728
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.81611512
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80959774
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80708456
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.80327078
146HNF4A_19822575_ChIP-Seq_HepG2_Human0.79984279
147TBL1_22424771_ChIP-Seq_293T_Human0.79795805
148TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79693968
149ESR2_21235772_ChIP-Seq_MCF-7_Human0.79545964
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79249836
151CBP_21632823_ChIP-Seq_H3396_Human0.79105966
152FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78904694
153AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78242879
154BCAT_22108803_ChIP-Seq_LS180_Human0.78219823
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.75311860
156EZH2_22144423_ChIP-Seq_EOC_Human0.74861045
157CLOCK_20551151_ChIP-Seq_293T_Human0.74799871
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.73258252
159TRIM28_21343339_ChIP-Seq_HEK293_Human0.71932691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.04746361
2MP0005360_urolithiasis5.13300949
3MP0008877_abnormal_DNA_methylation4.73026625
4MP0005365_abnormal_bile_salt4.61438915
5MP0005085_abnormal_gallbladder_physiolo4.36646467
6MP0008875_abnormal_xenobiotic_pharmacok4.03005378
7MP0003787_abnormal_imprinting3.74452371
8MP0003806_abnormal_nucleotide_metabolis3.29278588
9MP0003195_calcinosis2.88994495
10MP0002009_preneoplasia2.87761589
11MP0003252_abnormal_bile_duct2.82886478
12MP0010329_abnormal_lipoprotein_level2.75955013
13MP0003690_abnormal_glial_cell2.62852227
14MP0005451_abnormal_body_composition2.61504355
15MP0000920_abnormal_myelination2.61205305
16MP0000427_abnormal_hair_cycle2.57085178
17MP0005332_abnormal_amino_acid2.43726912
18MP0008995_early_reproductive_senescence2.37625573
19MP0003183_abnormal_peptide_metabolism2.33554993
20MP0002166_altered_tumor_susceptibility2.27969477
21MP0000569_abnormal_digit_pigmentation2.22859943
22MP0002118_abnormal_lipid_homeostasis2.16777856
23MP0008057_abnormal_DNA_replication2.12246682
24MP0010234_abnormal_vibrissa_follicle2.01320932
25MP0004270_analgesia1.95306886
26MP0001666_abnormal_nutrient_absorption1.94746708
27MP0009840_abnormal_foam_cell1.86556691
28MP0001501_abnormal_sleep_pattern1.82159502
29MP0005310_abnormal_salivary_gland1.81124107
30MP0005083_abnormal_biliary_tract1.79309459
31MP0003329_amyloid_beta_deposits1.78494088
32MP0003045_fibrosis1.77710015
33MP0004885_abnormal_endolymph1.72902222
34MP0004036_abnormal_muscle_relaxation1.69078189
35MP0003868_abnormal_feces_composition1.66476334
36MP0002160_abnormal_reproductive_system1.64905150
37MP0001661_extended_life_span1.61963409
38MP0000609_abnormal_liver_physiology1.59303843
39MP0005670_abnormal_white_adipose1.54990032
40MP0004130_abnormal_muscle_cell1.53408601
41MP0004145_abnormal_muscle_electrophysio1.51086818
42MP0003880_abnormal_central_pattern1.49950388
43MP0003828_pulmonary_edema1.48163502
44MP0003724_increased_susceptibility_to1.46499400
45MP0000604_amyloidosis1.42972666
46MP0005584_abnormal_enzyme/coenzyme_acti1.42806932
47MP0003191_abnormal_cellular_cholesterol1.40864720
48MP0010386_abnormal_urinary_bladder1.40797744
49MP0003763_abnormal_thymus_physiology1.39010842
50MP0005666_abnormal_adipose_tissue1.35527741
51MP0001800_abnormal_humoral_immune1.31616785
52MP0008961_abnormal_basal_metabolism1.30642637
53MP0001984_abnormal_olfaction1.27873165
54MP0002971_abnormal_brown_adipose1.27773905
55MP0004019_abnormal_vitamin_homeostasis1.27586288
56MP0003950_abnormal_plasma_membrane1.27064299
57MP0004484_altered_response_of1.24908926
58MP0002837_dystrophic_cardiac_calcinosis1.23380305
59MP0004859_abnormal_synaptic_plasticity1.21671090
60MP0004147_increased_porphyrin_level1.21331478
61MP0004185_abnormal_adipocyte_glucose1.21063016
62MP0004084_abnormal_cardiac_muscle1.20699508
63MP0001486_abnormal_startle_reflex1.19638774
64MP0002876_abnormal_thyroid_physiology1.18739611
65MP0002272_abnormal_nervous_system1.16897095
66MP0004215_abnormal_myocardial_fiber1.16615239
67MP0005389_reproductive_system_phenotype1.16396692
68MP0002229_neurodegeneration1.16070931
69MP0002006_tumorigenesis1.13166620
70MP0004742_abnormal_vestibular_system1.13122709
71MP0002909_abnormal_adrenal_gland1.12937818
72MP0003634_abnormal_glial_cell1.11659151
73MP0000685_abnormal_immune_system1.11032372
74MP0000613_abnormal_salivary_gland1.10891456
75MP0005379_endocrine/exocrine_gland_phen1.09881981
76MP0005319_abnormal_enzyme/_coenzyme1.07698578
77MP0009384_cardiac_valve_regurgitation1.07246953
78MP0005551_abnormal_eye_electrophysiolog1.05578519
79MP0001929_abnormal_gametogenesis1.05241646
80MP0002168_other_aberrant_phenotype1.03969881
81MP0010678_abnormal_skin_adnexa1.03081118
82MP0002127_abnormal_cardiovascular_syste1.02707078
83MP0005375_adipose_tissue_phenotype1.02322260
84MP0005408_hypopigmentation1.02241382
85MP0000465_gastrointestinal_hemorrhage1.02161850
86MP0001986_abnormal_taste_sensitivity1.01371423
87MP0004264_abnormal_extraembryonic_tissu1.01341600
88MP0004883_abnormal_blood_vessel1.01090468
89MP0003632_abnormal_nervous_system1.00890204
90MP0009115_abnormal_fat_cell1.00809155
91MP0003011_delayed_dark_adaptation1.00517233
92MP0004043_abnormal_pH_regulation1.00163002
93MP0001485_abnormal_pinna_reflex1.00001047
94MP0001944_abnormal_pancreas_morphology0.99047251
95MP0000383_abnormal_hair_follicle0.98504629
96MP0002064_seizures0.97793177
97MP0002210_abnormal_sex_determination0.97586255
98MP0002332_abnormal_exercise_endurance0.97300737
99MP0005535_abnormal_body_temperature0.97036512
100MP0005334_abnormal_fat_pad0.93378207
101MP0005075_abnormal_melanosome_morpholog0.92435040
102MP0002108_abnormal_muscle_morphology0.92165008
103MP0005647_abnormal_sex_gland0.91290527
104MP0003646_muscle_fatigue0.90974461
105MP0000653_abnormal_sex_gland0.90639189
106MP0009046_muscle_twitch0.90309941
107MP0001835_abnormal_antigen_presentation0.89949063
108MP0000749_muscle_degeneration0.89840738
109MP0002693_abnormal_pancreas_physiology0.89608473
110MP0001765_abnormal_ion_homeostasis0.89488254
111MP0003698_abnormal_male_reproductive0.88992713
112MP0009643_abnormal_urine_homeostasis0.88620833
113MP0000230_abnormal_systemic_arterial0.87611667
114MP0003656_abnormal_erythrocyte_physiolo0.86282611
115MP0008872_abnormal_physiological_respon0.86131780
116MP0005220_abnormal_exocrine_pancreas0.85895966
117MP0002078_abnormal_glucose_homeostasis0.85247014
118MP0000470_abnormal_stomach_morphology0.83120173
119MP0001440_abnormal_grooming_behavior0.82753783
120MP0003943_abnormal_hepatobiliary_system0.81755714
121MP0000639_abnormal_adrenal_gland0.80517295
122MP0001764_abnormal_homeostasis0.79773336
123MP0004142_abnormal_muscle_tone0.79682037
124MP0001145_abnormal_male_reproductive0.79475492
125MP0000003_abnormal_adipose_tissue0.79355156
126MP0005620_abnormal_muscle_contractility0.79002312
127MP0001905_abnormal_dopamine_level0.77431996
128MP0000778_abnormal_nervous_system0.77093429
129MP0008874_decreased_physiological_sensi0.76224707
130MP0009780_abnormal_chondrocyte_physiolo0.76145649
131MP0002638_abnormal_pupillary_reflex0.76070052
132MP0000372_irregular_coat_pigmentation0.75826758
133MP0005000_abnormal_immune_tolerance0.75768711
134MP0005409_darkened_coat_color0.75566655
135MP0001919_abnormal_reproductive_system0.75273956
136MP0005386_behavior/neurological_phenoty0.75199635
137MP0004924_abnormal_behavior0.75199635
138MP0005645_abnormal_hypothalamus_physiol0.74900374
139MP0009745_abnormal_behavioral_response0.74897909
140MP0001873_stomach_inflammation0.74152198
141MP0000462_abnormal_digestive_system0.74055622
142MP0000747_muscle_weakness0.73989540
143MP0005174_abnormal_tail_pigmentation0.73853846
144MP0004782_abnormal_surfactant_physiolog0.73086830
145MP0001790_abnormal_immune_system0.72746721
146MP0005387_immune_system_phenotype0.72746721
147MP0002295_abnormal_pulmonary_circulatio0.72242371
148MP0001502_abnormal_circadian_rhythm0.72108427
149MP0003635_abnormal_synaptic_transmissio0.72004978
150MP0002090_abnormal_vision0.71858009
151MP0001346_abnormal_lacrimal_gland0.71376670
152MP0003121_genomic_imprinting0.71173328
153MP0005646_abnormal_pituitary_gland0.71019854
154MP0001756_abnormal_urination0.69956618
155MP0005410_abnormal_fertilization0.69818251
156MP0002138_abnormal_hepatobiliary_system0.69046599
157MP0003631_nervous_system_phenotype0.68205294
158MP0002136_abnormal_kidney_physiology0.67252611
159MP0009765_abnormal_xenobiotic_induced0.65677008
160MP0001177_atelectasis0.65299020
161MP0002066_abnormal_motor_capabilities/c0.61724762
162MP0003633_abnormal_nervous_system0.61449087
163MP0000579_abnormal_nail_morphology0.61350288
164MP0002254_reproductive_system_inflammat0.61036679
165MP0000566_synostosis0.59299219
166MP0004381_abnormal_hair_follicle0.59261771
167MP0005448_abnormal_energy_balance0.59195041
168MP0001529_abnormal_vocalization0.58612718
169MP0009642_abnormal_blood_homeostasis0.56634880
170MP0002822_catalepsy0.55641546
171MP0000955_abnormal_spinal_cord0.55335639
172MP0009697_abnormal_copulation0.54545471
173MP0002734_abnormal_mechanical_nocicepti0.53301712

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.87351427
2Deep venous thrombosis (HP:0002625)5.62152493
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.39720255
4Hyperlipoproteinemia (HP:0010980)5.06256873
5Xanthomatosis (HP:0000991)4.75254676
6Sensory axonal neuropathy (HP:0003390)4.41220202
7Prolonged partial thromboplastin time (HP:0003645)4.37231850
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.26656421
9Complement deficiency (HP:0004431)4.19642889
10Hyperglycinemia (HP:0002154)4.10768788
11Lip pit (HP:0100267)3.92020317
12Neurofibrillary tangles (HP:0002185)3.86186409
13Ketosis (HP:0001946)3.86055776
14Hypobetalipoproteinemia (HP:0003563)3.79116387
15Abnormality of glycine metabolism (HP:0010895)3.69297754
16Abnormality of serine family amino acid metabolism (HP:0010894)3.69297754
17Degeneration of the lateral corticospinal tracts (HP:0002314)3.61226770
18Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.61226770
19Epidermoid cyst (HP:0200040)3.56331802
20Muscle hypertrophy of the lower extremities (HP:0008968)3.46641765
21Hyperammonemia (HP:0001987)3.40133419
22Parakeratosis (HP:0001036)3.37910306
23Hyperglycinuria (HP:0003108)3.33768060
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.25651252
25Fair hair (HP:0002286)3.25512013
26Conjugated hyperbilirubinemia (HP:0002908)3.24444090
27Gaze-evoked nystagmus (HP:0000640)3.14435670
28Fat malabsorption (HP:0002630)3.13797649
29Febrile seizures (HP:0002373)3.11964016
30Abnormality of the corticospinal tract (HP:0002492)3.11447435
31Hypolipoproteinemia (HP:0010981)3.08919715
32Abnormality of methionine metabolism (HP:0010901)3.00408746
33Spastic paraparesis (HP:0002313)3.00222250
34Hypoalphalipoproteinemia (HP:0003233)2.99928751
35Ketoacidosis (HP:0001993)2.99261542
36Volvulus (HP:0002580)2.96240213
37Calf muscle hypertrophy (HP:0008981)2.91963583
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91215843
39Hyperkalemia (HP:0002153)2.89021213
40Generalized hypopigmentation of hair (HP:0011358)2.84220970
41Decreased circulating renin level (HP:0003351)2.82849888
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.82648780
43Intention tremor (HP:0002080)2.81575042
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.79086770
45Cerebral inclusion bodies (HP:0100314)2.78996732
46Hypoglycemic coma (HP:0001325)2.77033934
47Metaphyseal dysplasia (HP:0100255)2.76930204
48Joint hemorrhage (HP:0005261)2.75808316
49Abnormality of fatty-acid metabolism (HP:0004359)2.74532124
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.72609988
51Absent/shortened dynein arms (HP:0200106)2.72609988
52Abnormal rod and cone electroretinograms (HP:0008323)2.71958616
53Papillary thyroid carcinoma (HP:0002895)2.67502570
54Thyroiditis (HP:0100646)2.65433576
55Tubulointerstitial nephritis (HP:0001970)2.64738273
56Spastic gait (HP:0002064)2.64467095
57Chronic hepatic failure (HP:0100626)2.59532049
58Neoplasm of the tracheobronchial system (HP:0100552)2.56499182
59Abnormality of glutamine family amino acid metabolism (HP:0010902)2.55053714
60Abnormality of complement system (HP:0005339)2.55041630
61Steatorrhea (HP:0002570)2.54714244
62Abnormality of the common coagulation pathway (HP:0010990)2.54487196
63Truncal obesity (HP:0001956)2.54292211
64Genetic anticipation (HP:0003743)2.53488790
65Abnormality of the renal cortex (HP:0011035)2.51079648
66Hypercholesterolemia (HP:0003124)2.47995244
67Hyperventilation (HP:0002883)2.43861169
68Widely spaced teeth (HP:0000687)2.43606414
69Alveolar cell carcinoma (HP:0006519)2.41582107
70Sparse lateral eyebrow (HP:0005338)2.41189252
71Chronic sinusitis (HP:0011109)2.40134639
72Abnormality of serum amino acid levels (HP:0003112)2.39725971
73Stomach cancer (HP:0012126)2.39057995
74Abnormal ciliary motility (HP:0012262)2.38599250
75Akinesia (HP:0002304)2.35895542
76Supranuclear gaze palsy (HP:0000605)2.34370165
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32632994
78Abnormality of the axillary hair (HP:0100134)2.32173350
79Abnormality of secondary sexual hair (HP:0009888)2.32173350
80Delayed CNS myelination (HP:0002188)2.29541530
81Abnormality of the intrinsic pathway (HP:0010989)2.25522094
82Macroorchidism (HP:0000053)2.23998712
83Recurrent bronchitis (HP:0002837)2.23519929
84Hematochezia (HP:0002573)2.21690313
85Gonadotropin excess (HP:0000837)2.21628972
86Abnormal respiratory motile cilium physiology (HP:0012261)2.21352120
87Dicarboxylic aciduria (HP:0003215)2.21037872
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21037872
89Mitral stenosis (HP:0001718)2.19608863
90Attenuation of retinal blood vessels (HP:0007843)2.19456799
91Paraparesis (HP:0002385)2.18848067
92Vascular calcification (HP:0004934)2.17660076
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16792401
94Abnormal respiratory motile cilium morphology (HP:0005938)2.16691551
95Abnormal respiratory epithelium morphology (HP:0012253)2.16691551
96Hyperbilirubinemia (HP:0002904)2.15348012
97Progressive cerebellar ataxia (HP:0002073)2.14368220
98Curly hair (HP:0002212)2.14104338
99Hypoglycemic seizures (HP:0002173)2.13939228
100Tubular atrophy (HP:0000092)2.13785944
101Methylmalonic acidemia (HP:0002912)2.12803462
102Bronchiectasis (HP:0002110)2.11849920
103Metabolic acidosis (HP:0001942)2.10847670
104Neonatal hypoglycemia (HP:0001998)2.10605195
105Testicular neoplasm (HP:0010788)2.09539329
106Hypothermia (HP:0002045)2.08101635
107Cone-rod dystrophy (HP:0000548)2.08087615
108Cerebral hemorrhage (HP:0001342)2.06506512
109Dysmetria (HP:0001310)2.06029870
110Rimmed vacuoles (HP:0003805)2.05365705
111Chronic diarrhea (HP:0002028)2.04873735
112Skin nodule (HP:0200036)2.04541366
113Slow saccadic eye movements (HP:0000514)2.03056079
114Absent speech (HP:0001344)2.03010874
115Scanning speech (HP:0002168)2.01850077
116Medial flaring of the eyebrow (HP:0010747)2.01264860
117Abnormality of the frontal sinuses (HP:0002687)2.01217668
118Hypophosphatemic rickets (HP:0004912)2.00925209
119Hemorrhage of the eye (HP:0011885)1.98548680
120Bronchitis (HP:0012387)1.98458682
121Pigmentary retinal degeneration (HP:0001146)1.97957021
122Rhinitis (HP:0012384)1.97041577
123Urinary bladder sphincter dysfunction (HP:0002839)1.96069916
124Thickened helices (HP:0000391)1.95816553
125Abnormal gallbladder morphology (HP:0012437)1.95664235
126Abnormal pancreas size (HP:0012094)1.94753032
127Abnormality of vitamin metabolism (HP:0100508)1.93394059
128Cardiovascular calcification (HP:0011915)1.92671219
129Abnormality of the renal medulla (HP:0100957)1.92367350
130Amyloidosis (HP:0011034)1.92336103
131Papilledema (HP:0001085)1.92226049
132Hyperinsulinemic hypoglycemia (HP:0000825)1.92193704
133Impaired vibratory sensation (HP:0002495)1.91977244
134Onion bulb formation (HP:0003383)1.91906705
135Infantile muscular hypotonia (HP:0008947)1.91837132
136Azoospermia (HP:0000027)1.91500070
137Exercise-induced myalgia (HP:0003738)1.90497296
138Recurrent sinusitis (HP:0011108)1.89989380
139Dysdiadochokinesis (HP:0002075)1.87927227
140Abnormality of purine metabolism (HP:0004352)1.87700904
141Syncope (HP:0001279)1.86391423
142Turricephaly (HP:0000262)1.85711056
143Exocrine pancreatic insufficiency (HP:0001738)1.85048973
144Brushfield spots (HP:0001088)1.83327671
145Spontaneous hematomas (HP:0007420)1.82136598
146Breast carcinoma (HP:0003002)1.81738046
147Malnutrition (HP:0004395)1.81727417
148Acute myeloid leukemia (HP:0004808)1.81288050
149Myocardial infarction (HP:0001658)1.80518336
150Pancreatic cysts (HP:0001737)1.80016442
151Hip dysplasia (HP:0001385)1.79823141
152Abnormality of the fingertips (HP:0001211)1.79770404
153Back pain (HP:0003418)1.79447504
154Bundle branch block (HP:0011710)1.79267158
155Lethargy (HP:0001254)1.78446660
156Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77022042
157Spontaneous abortion (HP:0005268)1.76824264
158Hyporeflexia of lower limbs (HP:0002600)1.76278109
159Rickets (HP:0002748)1.75903012
160Macular degeneration (HP:0000608)1.75808191
161Hypoplastic iliac wings (HP:0002866)1.74746690
162Increased circulating renin level (HP:0000848)1.74308286
163Gout (HP:0001997)1.73577327
164Methylmalonic aciduria (HP:0012120)1.73084431
165Thyroid carcinoma (HP:0002890)1.72194921
166Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.70930468
167Nephronophthisis (HP:0000090)1.70284699
168Dysmetric saccades (HP:0000641)1.69838118
169Cholelithiasis (HP:0001081)1.69795661
170Irritability (HP:0000737)1.69540714
171Pancreatitis (HP:0001733)1.69472513
172Generalized myoclonic seizures (HP:0002123)1.69050806
173Enlarged penis (HP:0000040)1.68938871
174Generalized aminoaciduria (HP:0002909)1.66811778
175Depressed nasal tip (HP:0000437)1.66721385
176Spastic tetraparesis (HP:0001285)1.65526673
177Alkalosis (HP:0001948)1.65354627
178Overgrowth (HP:0001548)1.64937507
179Morphological abnormality of the pyramidal tract (HP:0002062)1.63855243
180Bony spicule pigmentary retinopathy (HP:0007737)1.63282002
181Status epilepticus (HP:0002133)1.63219782
182Alacrima (HP:0000522)1.63218020
183Protuberant abdomen (HP:0001538)1.63153282
184Difficulty running (HP:0009046)1.62708102
185Concave nail (HP:0001598)1.62587964
186Abnormality of the calf musculature (HP:0001430)1.62011970
187Chronic bronchitis (HP:0004469)1.62005958
188Germ cell neoplasia (HP:0100728)1.61642351
189Pancreatic fibrosis (HP:0100732)1.60276119
190Infertility (HP:0000789)1.58692328
191Gait imbalance (HP:0002141)1.57207863
192Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56050235
193Autoimmune hemolytic anemia (HP:0001890)1.55999172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.02021696
2FRK4.50201802
3OXSR14.07959883
4TNIK3.99574712
5AKT33.11757436
6MST42.78847388
7BRSK22.78577935
8FGFR22.63382057
9EPHB12.59853199
10ICK2.50652280
11BCKDK2.33017763
12CDK192.28594473
13CASK2.18142665
14WNK42.14323321
15INSRR2.10021190
16TRPM72.08711714
17EPHA42.02123774
18MAP3K131.98789023
19PRPF4B1.97071229
20MET1.91004836
21BCR1.87289634
22SIK11.87196555
23EIF2AK31.86025331
24PAK61.85508998
25MAP3K121.83422598
26BMPR21.78015039
27ERBB41.74194515
28FER1.71170864
29WNK11.65860767
30NEK61.60453051
31CAMK1G1.55580703
32TNK21.55005492
33PKN11.45501686
34CSNK1A1L1.42409883
35PAK31.42158690
36FGFR31.39481237
37NLK1.30244116
38FGFR41.29474821
39CAMK1D1.27605097
40IKBKE1.27367875
41CSNK1G31.26416081
42TEC1.25339365
43CSNK1G11.22181473
44CAMKK21.21446086
45BMPR1B1.18899010
46CSNK1G21.13091639
47TAOK31.11584214
48GRK11.09705993
49LATS11.08619927
50ACVR1B1.06132643
51MAPK131.04340238
52SGK4941.03791186
53SGK2231.03791186
54MARK21.02287647
55MAP3K70.97874678
56MAPKAPK30.97779413
57ARAF0.97069137
58MAP3K90.95103252
59NTRK10.94476978
60PRKCQ0.93376853
61MARK30.91805204
62TRIM280.91654610
63KSR20.90976171
64PDPK10.90436377
65PRKCH0.89315190
66PHKG10.88958261
67PHKG20.88958261
68PRKAA20.87986347
69RPS6KB10.85062677
70MAPK150.84055242
71YES10.83090455
72BRD40.82976105
73CAMK2G0.80973016
74MAP2K40.78449172
75ERBB30.76169176
76PINK10.75218807
77KIT0.74864572
78CAMK2B0.73843032
79MAP3K10.73807278
80TYRO30.73762952
81SIK30.73269196
82CDK50.72817052
83IRAK20.71814107
84IRAK10.71550859
85CAMK2D0.71538678
86BTK0.71536029
87CHUK0.71496784
88STK110.71166647
89MAPK70.71023631
90CDK120.70934109
91SGK30.70336012
92MUSK0.69460760
93ROCK20.68383357
94STK380.68168970
95IKBKB0.68140838
96OBSCN0.65123368
97MAP2K10.64679392
98IRAK40.63639155
99MARK10.62680627
100MAP4K10.62460315
101PIK3CG0.61043413
102PDK10.59908370
103PNCK0.59799442
104DYRK1A0.58508586
105FES0.57746324
106DAPK20.57430498
107MAP3K40.57306843
108NEK90.56314482
109FYN0.55301065
110HCK0.54587031
111SGK10.54213592
112SYK0.53692481
113STK38L0.53125586
114PRKCI0.52853368
115PDGFRB0.51771233
116CAMK2A0.51705563
117FGR0.51376769
118UHMK10.50129446
119MELK0.50079943
120PRKCE0.49017180
121BLK0.48659351
122PTK2B0.48602782
123TYK20.48556614
124NTRK30.47022257
125MAP3K100.46744413
126PBK0.46678056
127PRKD10.46102982
128ERN10.46008809
129PRKAA10.45790135
130ITK0.45610237
131CDK30.45156021
132MAPK110.45038756
133EPHA30.44878553
134RIPK40.44432405
135KSR10.44317796
136JAK20.44245430
137HIPK20.43058383
138WEE10.42539041
139PIK3CA0.42237136
140NUAK10.42044073
141MAPK120.41767322
142PRKG10.41672988
143PKN20.40629355
144PRKD20.40547607
145SGK20.39635084
146CSK0.39484268
147JAK10.39415771
148CAMKK10.39403117
149PRKCZ0.36887488
150RET0.35356124
151NTRK20.35111757
152ABL10.34390738
153MAP3K20.34323886
154ERBB20.33929974
155CDK140.33145148
156CSNK1D0.33099603
157PRKACG0.31058757
158GSK3A0.30430067
159PRKCG0.29733152
160MAP3K60.29327755

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.66007645
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.06443669
3Nitrogen metabolism_Homo sapiens_hsa009102.86808716
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61971444
5Butanoate metabolism_Homo sapiens_hsa006502.58431380
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50508532
7Fatty acid elongation_Homo sapiens_hsa000622.47644886
8Fatty acid degradation_Homo sapiens_hsa000712.41696206
9Propanoate metabolism_Homo sapiens_hsa006402.40049485
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.35888700
11Steroid biosynthesis_Homo sapiens_hsa001002.32491366
12Fatty acid metabolism_Homo sapiens_hsa012122.31878337
13Tryptophan metabolism_Homo sapiens_hsa003802.30192139
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23151012
15Arginine biosynthesis_Homo sapiens_hsa002202.18104209
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.13956682
17Complement and coagulation cascades_Homo sapiens_hsa046102.09980378
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07113001
19PPAR signaling pathway_Homo sapiens_hsa033201.98370195
20Peroxisome_Homo sapiens_hsa041461.93825320
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91119429
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.84598506
23Sulfur metabolism_Homo sapiens_hsa009201.71797260
24Histidine metabolism_Homo sapiens_hsa003401.71038292
25B cell receptor signaling pathway_Homo sapiens_hsa046621.67636407
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61874558
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56351461
28beta-Alanine metabolism_Homo sapiens_hsa004101.55817905
29Chemical carcinogenesis_Homo sapiens_hsa052041.55782806
30Caffeine metabolism_Homo sapiens_hsa002321.54551831
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51798473
32FoxO signaling pathway_Homo sapiens_hsa040681.48646523
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48603606
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48335939
35Inositol phosphate metabolism_Homo sapiens_hsa005621.42658133
36Retinol metabolism_Homo sapiens_hsa008301.40855262
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40482451
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40336842
39mTOR signaling pathway_Homo sapiens_hsa041501.34995810
40Fatty acid biosynthesis_Homo sapiens_hsa000611.32841573
41Bile secretion_Homo sapiens_hsa049761.32221904
42Pyruvate metabolism_Homo sapiens_hsa006201.28432623
43Vitamin B6 metabolism_Homo sapiens_hsa007501.24977272
44T cell receptor signaling pathway_Homo sapiens_hsa046601.24680582
45Staphylococcus aureus infection_Homo sapiens_hsa051501.24363265
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.19978854
47Tyrosine metabolism_Homo sapiens_hsa003501.19852697
48ABC transporters_Homo sapiens_hsa020101.19579948
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18865195
50Phototransduction_Homo sapiens_hsa047441.18706123
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13439052
52Renin secretion_Homo sapiens_hsa049241.10413451
53Endometrial cancer_Homo sapiens_hsa052131.09680758
54Glycerolipid metabolism_Homo sapiens_hsa005611.09491735
55Prolactin signaling pathway_Homo sapiens_hsa049171.08358638
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07864770
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07162742
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.05807825
59Choline metabolism in cancer_Homo sapiens_hsa052311.05001193
60Phenylalanine metabolism_Homo sapiens_hsa003601.04660940
61Arginine and proline metabolism_Homo sapiens_hsa003301.04041177
62Drug metabolism - other enzymes_Homo sapiens_hsa009831.03253785
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01845269
64Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00921711
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98119479
66Fat digestion and absorption_Homo sapiens_hsa049750.94920595
67Type I diabetes mellitus_Homo sapiens_hsa049400.94087797
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93612269
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93504154
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.91755114
71Ether lipid metabolism_Homo sapiens_hsa005650.87049541
72Oxytocin signaling pathway_Homo sapiens_hsa049210.86617363
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85101472
74Acute myeloid leukemia_Homo sapiens_hsa052210.84421166
75Prostate cancer_Homo sapiens_hsa052150.83510005
76Amphetamine addiction_Homo sapiens_hsa050310.83162714
77Starch and sucrose metabolism_Homo sapiens_hsa005000.82691506
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82405251
79Non-small cell lung cancer_Homo sapiens_hsa052230.81559515
80Platelet activation_Homo sapiens_hsa046110.81047588
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.80407807
82Insulin signaling pathway_Homo sapiens_hsa049100.77421922
83ErbB signaling pathway_Homo sapiens_hsa040120.77384426
84Lysine degradation_Homo sapiens_hsa003100.75967333
85Salivary secretion_Homo sapiens_hsa049700.74381307
86Measles_Homo sapiens_hsa051620.73070783
87Linoleic acid metabolism_Homo sapiens_hsa005910.72987360
88Olfactory transduction_Homo sapiens_hsa047400.72056784
89Estrogen signaling pathway_Homo sapiens_hsa049150.71374812
90Circadian entrainment_Homo sapiens_hsa047130.71311459
91Allograft rejection_Homo sapiens_hsa053300.70636843
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70401722
93Vitamin digestion and absorption_Homo sapiens_hsa049770.70308625
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69853562
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.69521172
96Long-term depression_Homo sapiens_hsa047300.68690830
97Carbon metabolism_Homo sapiens_hsa012000.68218333
98Pancreatic secretion_Homo sapiens_hsa049720.68138959
99Primary immunodeficiency_Homo sapiens_hsa053400.68043391
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.67529653
101Folate biosynthesis_Homo sapiens_hsa007900.66763567
102Taste transduction_Homo sapiens_hsa047420.64583889
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.63343409
104Cholinergic synapse_Homo sapiens_hsa047250.63115326
105Calcium signaling pathway_Homo sapiens_hsa040200.62086993
106Dopaminergic synapse_Homo sapiens_hsa047280.61976894
107Ovarian steroidogenesis_Homo sapiens_hsa049130.61322722
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60567760
109Osteoclast differentiation_Homo sapiens_hsa043800.59893666
110Hepatitis C_Homo sapiens_hsa051600.59781198
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.59552386
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59007515
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58694736
114Selenocompound metabolism_Homo sapiens_hsa004500.58431123
115TNF signaling pathway_Homo sapiens_hsa046680.57863363
116Toxoplasmosis_Homo sapiens_hsa051450.57443000
117Influenza A_Homo sapiens_hsa051640.56611940
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56177842
119Tuberculosis_Homo sapiens_hsa051520.55767104
120Biosynthesis of amino acids_Homo sapiens_hsa012300.54472389
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54128148
122Glutathione metabolism_Homo sapiens_hsa004800.54076915
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53078301
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51973930
125Glioma_Homo sapiens_hsa052140.50504894
126Autoimmune thyroid disease_Homo sapiens_hsa053200.50383817
127Axon guidance_Homo sapiens_hsa043600.48801631
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48369109
129GABAergic synapse_Homo sapiens_hsa047270.45173349
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.44956623
131Metabolic pathways_Homo sapiens_hsa011000.40882379
132Sulfur relay system_Homo sapiens_hsa041220.34239084
133Regulation of autophagy_Homo sapiens_hsa041400.34196004
134Glutamatergic synapse_Homo sapiens_hsa047240.30789302
135Insulin resistance_Homo sapiens_hsa049310.29966445
136AMPK signaling pathway_Homo sapiens_hsa041520.29918870
137Sphingolipid metabolism_Homo sapiens_hsa006000.29597191
138Prion diseases_Homo sapiens_hsa050200.26642254
139Protein export_Homo sapiens_hsa030600.24442399
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21968627
141Pentose phosphate pathway_Homo sapiens_hsa000300.21153048
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.20502112
143Dorso-ventral axis formation_Homo sapiens_hsa043200.19320320
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18202750
145Morphine addiction_Homo sapiens_hsa050320.17255679
146Circadian rhythm_Homo sapiens_hsa047100.17151463
147Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16551716
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15370918
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15340085
150Renal cell carcinoma_Homo sapiens_hsa052110.14163067
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.13849250
152Glucagon signaling pathway_Homo sapiens_hsa049220.13077688
153cAMP signaling pathway_Homo sapiens_hsa040240.11547296
154Cocaine addiction_Homo sapiens_hsa050300.09897078
155Thyroid hormone synthesis_Homo sapiens_hsa049180.09840224
156Insulin secretion_Homo sapiens_hsa049110.09819936
157Vascular smooth muscle contraction_Homo sapiens_hsa042700.09249521
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.07817300
159Serotonergic synapse_Homo sapiens_hsa047260.07450306
160Type II diabetes mellitus_Homo sapiens_hsa049300.07016413

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