FAM209A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.24302842
2response to pheromone (GO:0019236)9.09459410
3DNA packaging (GO:0006323)8.85941060
4sperm capacitation (GO:0048240)8.79174549
5plasma membrane fusion (GO:0045026)8.39665473
6spermatid nucleus differentiation (GO:0007289)7.96196008
7microtubule depolymerization (GO:0007019)7.88785122
8single strand break repair (GO:0000012)7.81496572
9spermatid development (GO:0007286)7.52785082
10sperm-egg recognition (GO:0035036)7.31508798
11rRNA methylation (GO:0031167)7.04144143
12multicellular organism reproduction (GO:0032504)6.78275370
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.69135914
14protein targeting to Golgi (GO:0000042)6.69099664
15binding of sperm to zona pellucida (GO:0007339)6.57573983
16microtubule polymerization or depolymerization (GO:0031109)6.47207352
17protein polyglutamylation (GO:0018095)6.46251441
18negative regulation of inclusion body assembly (GO:0090084)6.43975627
19reproduction (GO:0000003)6.40598996
20establishment of protein localization to Golgi (GO:0072600)6.40250711
21sexual reproduction (GO:0019953)6.27752949
22calcium ion-dependent exocytosis (GO:0017156)6.22616546
23retrograde transport, vesicle recycling within Golgi (GO:0000301)6.21671239
24phosphatidylethanolamine biosynthetic process (GO:0006646)6.16082793
25cell-cell recognition (GO:0009988)6.02032531
26rRNA modification (GO:0000154)6.00582015
27spermatogenesis (GO:0007283)5.94600473
28male gamete generation (GO:0048232)5.92460481
29centriole replication (GO:0007099)5.83333979
30axonemal dynein complex assembly (GO:0070286)5.82832962
31phosphatidylethanolamine metabolic process (GO:0046337)5.70411182
32RNA destabilization (GO:0050779)5.54708188
33gamete generation (GO:0007276)5.42181027
34positive regulation of Rab GTPase activity (GO:0032851)5.15677497
35regulation of Rab GTPase activity (GO:0032313)5.15677497
36cellular ketone body metabolic process (GO:0046950)5.15596656
37centriole assembly (GO:0098534)5.11440564
38protein localization to Golgi apparatus (GO:0034067)5.09713673
39microtubule severing (GO:0051013)4.98193393
40regulation of cilium movement (GO:0003352)4.85699334
41motile cilium assembly (GO:0044458)4.78030239
42single fertilization (GO:0007338)4.75135981
43chromatin silencing (GO:0006342)4.59443963
44cell wall macromolecule catabolic process (GO:0016998)4.56855584
45ketone body metabolic process (GO:1902224)4.55710952
46regulation of inclusion body assembly (GO:0090083)4.46956424
47regulation of transcription involved in cell fate commitment (GO:0060850)4.40984753
48cilium or flagellum-dependent cell motility (GO:0001539)4.39526177
49multicellular organismal reproductive process (GO:0048609)4.33140665
50germ cell development (GO:0007281)4.29895105
51cell wall macromolecule metabolic process (GO:0044036)4.29325818
52negative regulation of Rho protein signal transduction (GO:0035024)4.22713295
53cellular process involved in reproduction in multicellular organism (GO:0022412)4.16310276
54regulation of somitogenesis (GO:0014807)4.14027004
55regulation of T-helper 2 cell differentiation (GO:0045628)3.98422824
56seminiferous tubule development (GO:0072520)3.92196778
57fertilization (GO:0009566)3.91268372
58nucleus organization (GO:0006997)3.89140993
59regulation of centriole replication (GO:0046599)3.78246572
60glycerol ether metabolic process (GO:0006662)3.73365433
61coenzyme catabolic process (GO:0009109)3.63518307
62epithelial cilium movement (GO:0003351)3.47906028
63organic cation transport (GO:0015695)3.46057181
64ether metabolic process (GO:0018904)3.42941115
65regulation of interleukin-13 production (GO:0032656)3.42850645
66multicellular organismal movement (GO:0050879)3.39684584
67musculoskeletal movement (GO:0050881)3.39684584
68regulation of microtubule-based movement (GO:0060632)3.38103358
69microtubule nucleation (GO:0007020)3.29684639
70NAD biosynthetic process (GO:0009435)3.26779478
71peptidyl-threonine dephosphorylation (GO:0035970)3.24642617
72negative regulation of gene expression, epigenetic (GO:0045814)3.21809259
73histone H3-K9 demethylation (GO:0033169)3.21444040
74polyamine biosynthetic process (GO:0006596)3.16594611
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.14901574
76cranial nerve morphogenesis (GO:0021602)3.07826551
77response to acidic pH (GO:0010447)3.07688537
78homeostasis of number of cells within a tissue (GO:0048873)3.03305709
79cilium movement (GO:0003341)3.00477102
80cellular response to pH (GO:0071467)2.97591802
81multicellular organismal development (GO:0007275)2.93472662
82cerebral cortex neuron differentiation (GO:0021895)2.92999553
83membrane protein intracellular domain proteolysis (GO:0031293)2.92192925
84protein-DNA complex disassembly (GO:0032986)2.88026027
85nucleosome disassembly (GO:0006337)2.88026027
86cell differentiation involved in metanephros development (GO:0072202)2.85435911
87cell recognition (GO:0008037)2.81297460
88regulation of ARF GTPase activity (GO:0032312)2.80120747
89negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.78277205
90glomerular visceral epithelial cell development (GO:0072015)2.76130156
91tooth mineralization (GO:0034505)2.72893039
92positive regulation of type 2 immune response (GO:0002830)2.72480026
93detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.70004330
94positive regulation of T cell mediated cytotoxicity (GO:0001916)2.69946439
95mesenchymal cell differentiation involved in kidney development (GO:0072161)2.68981496
96mesenchymal cell differentiation involved in renal system development (GO:2001012)2.68981496
97protein depolymerization (GO:0051261)2.67857853
98acrosome reaction (GO:0007340)11.7366327
99sperm motility (GO:0030317)11.2191454
100fusion of sperm to egg plasma membrane (GO:0007342)11.1025121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.84711837
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.82371804
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.03590583
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43007665
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.43007665
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.23632133
7ELF1_20517297_ChIP-Seq_JURKAT_Human2.06737528
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04586991
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.98474901
10CBP_20019798_ChIP-Seq_JUKART_Human1.98474901
11CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98172430
12DROSHA_22980978_ChIP-Seq_HELA_Human1.95848442
13EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.93859287
14RUNX_20019798_ChIP-Seq_JUKART_Human1.92499605
15ERA_21632823_ChIP-Seq_H3396_Human1.90980914
16RAC3_21632823_ChIP-Seq_H3396_Human1.89669014
17NANOG_20526341_ChIP-Seq_ESCs_Human1.87534836
18* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.87150771
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86375495
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78304966
21BCL6_27268052_Chip-Seq_Bcells_Human1.76324439
22E2F1_20622854_ChIP-Seq_HELA_Human1.72264172
23EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.69467518
24CTCF_27219007_Chip-Seq_Bcells_Human1.65770903
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65579360
26BCOR_27268052_Chip-Seq_Bcells_Human1.65331375
27TDRD3_21172665_ChIP-Seq_MCF-7_Human1.64995414
28FUS_26573619_Chip-Seq_HEK293_Human1.64814412
29WDR5_24793694_ChIP-Seq_LNCAP_Human1.62861689
30TAF2_19829295_ChIP-Seq_ESCs_Human1.61475636
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60193719
32MYC_19829295_ChIP-Seq_ESCs_Human1.56235610
33YY1_22570637_ChIP-Seq_MALME-3M_Human1.55012151
34P68_20966046_ChIP-Seq_HELA_Human1.54320573
35SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52825691
36ER_23166858_ChIP-Seq_MCF-7_Human1.52191064
37EZH2_22144423_ChIP-Seq_EOC_Human1.51016277
38P300_27268052_Chip-Seq_Bcells_Human1.49570746
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.49057772
40PHF8_20622854_ChIP-Seq_HELA_Human1.48236880
41OCT4_20526341_ChIP-Seq_ESCs_Human1.47849018
42SMC4_20622854_ChIP-Seq_HELA_Human1.47563053
43LXR_22292898_ChIP-Seq_THP-1_Human1.45053484
44CTCF_20526341_ChIP-Seq_ESCs_Human1.44535259
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.41128275
46TP63_22573176_ChIP-Seq_HFKS_Human1.40195639
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.39871859
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39566031
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.35566978
50CEBPB_22108803_ChIP-Seq_LS180_Human1.35378510
51SMAD4_21741376_ChIP-Seq_EPCs_Human1.33541206
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30266739
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.30192016
54CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29761982
55ERG_20517297_ChIP-Seq_VCAP_Human1.29275135
56AR_25329375_ChIP-Seq_VCAP_Human1.28973400
57RBPJ_21746931_ChIP-Seq_IB4_Human1.27980162
58VDR_24787735_ChIP-Seq_THP-1_Human1.27370502
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26885483
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.26191139
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.26151916
62TAF15_26573619_Chip-Seq_HEK293_Human1.25936085
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24716777
64SOX2_22085726_ChIP-Seq_NPCs_Mouse1.24400770
65ETV1_20927104_ChIP-Seq_GIST48_Human1.23772274
66P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.22865464
67SA1_27219007_Chip-Seq_Bcells_Human1.21130244
68KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20733186
69SMRT_27268052_Chip-Seq_Bcells_Human1.18269821
70GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18153398
71SMAD3_21741376_ChIP-Seq_ESCs_Human1.15544041
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15140689
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14399321
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12829452
75GATA1_19941826_ChIP-Seq_K562_Human1.12131936
76P53_21459846_ChIP-Seq_SAOS-2_Human1.11916321
77SPI1_20517297_ChIP-Seq_HL60_Human1.11419812
78NFYB_21822215_ChIP-Seq_K562_Human1.10806071
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10034041
80OCT1_27270436_Chip-Seq_PROSTATE_Human1.09417975
81TBL1_22424771_ChIP-Seq_293T_Human1.07581280
82GATA6_21074721_ChIP-Seq_CACO-2_Human1.05926923
83PHF8_20622853_ChIP-Seq_HELA_Human1.05815730
84TP53_18474530_ChIP-ChIP_U2OS_Human1.05006913
85STAT1_20625510_ChIP-Seq_HELA_Human1.04300555
86P300_19829295_ChIP-Seq_ESCs_Human1.03308153
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.02658856
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01761844
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00348585
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.00161721
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98749682
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.97687522
93FOXH1_21741376_ChIP-Seq_ESCs_Human0.96779382
94SOX2_19829295_ChIP-Seq_ESCs_Human0.96701283
95NANOG_19829295_ChIP-Seq_ESCs_Human0.96701283
96RUNX2_22187159_ChIP-Seq_PCA_Human0.96012830
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95776473
98NFYA_21822215_ChIP-Seq_K562_Human0.95135746
99RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93882877
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93871331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.41507606
2MP0003878_abnormal_ear_physiology5.41507606
3MP0005670_abnormal_white_adipose4.21673340
4MP0003698_abnormal_male_reproductive4.08964135
5MP0001929_abnormal_gametogenesis3.51210897
6MP0001348_abnormal_lacrimal_gland3.33602801
7MP0002132_abnormal_respiratory_system2.85239172
8MP0000678_abnormal_parathyroid_gland2.51016199
9MP0002161_abnormal_fertility/fecundity2.22310782
10MP0005379_endocrine/exocrine_gland_phen2.15780327
11MP0003011_delayed_dark_adaptation2.04432964
12MP0005410_abnormal_fertilization11.5663980
13MP0003646_muscle_fatigue1.99002465
14MP0004510_myositis1.91393438
15MP0003718_maternal_effect1.74596011
16MP0005310_abnormal_salivary_gland1.74334319
17MP0005423_abnormal_somatic_nervous1.49950665
18MP0002234_abnormal_pharynx_morphology1.48182887
19MP0002138_abnormal_hepatobiliary_system1.43654397
20MP0002249_abnormal_larynx_morphology1.42927033
21MP0002210_abnormal_sex_determination1.42318684
22MP0001485_abnormal_pinna_reflex1.35573349
23MP0001486_abnormal_startle_reflex1.35230205
24MP0002282_abnormal_trachea_morphology1.29237392
25MP0001145_abnormal_male_reproductive1.24834756
26MP0002735_abnormal_chemical_nociception1.22802297
27MP0002822_catalepsy1.19047413
28MP0000653_abnormal_sex_gland1.18399828
29MP0002127_abnormal_cardiovascular_syste1.17949634
30MP0008877_abnormal_DNA_methylation1.15618290
31MP0005451_abnormal_body_composition1.15437789
32MP0001968_abnormal_touch/_nociception1.13700526
33MP0001765_abnormal_ion_homeostasis1.09935056
34MP0004742_abnormal_vestibular_system1.06147086
35MP0000681_abnormal_thyroid_gland1.01768343
36MP0009053_abnormal_anal_canal1.01567682
37MP0001963_abnormal_hearing_physiology0.99673675
38MP0005248_abnormal_Harderian_gland0.98970451
39MP0003436_decreased_susceptibility_to0.97162329
40MP0000026_abnormal_inner_ear0.93886510
41MP0006292_abnormal_olfactory_placode0.90258953
42MP0009764_decreased_sensitivity_to0.89033814
43MP0003724_increased_susceptibility_to0.88331030
44MP0001835_abnormal_antigen_presentation0.86826545
45MP0002733_abnormal_thermal_nociception0.85676473
46MP0005167_abnormal_blood-brain_barrier0.83544322
47MP0005084_abnormal_gallbladder_morpholo0.83451712
48MP0008961_abnormal_basal_metabolism0.81865389
49MP0009115_abnormal_fat_cell0.80838467
50MP0002163_abnormal_gland_morphology0.78817885
51MP0003303_peritoneal_inflammation0.76121583
52MP0005395_other_phenotype0.74430172
53MP0003879_abnormal_hair_cell0.73161315
54MP0009785_altered_susceptibility_to0.72637939
55MP0000534_abnormal_ureter_morphology0.71670183
56MP0008995_early_reproductive_senescence0.71201545
57MP0002723_abnormal_immune_serum0.70617624
58MP0005666_abnormal_adipose_tissue0.69774737
59MP0002419_abnormal_innate_immunity0.69330564
60MP0002067_abnormal_sensory_capabilities0.68095577
61MP0001800_abnormal_humoral_immune0.67098863
62MP0002229_neurodegeneration0.66959277
63MP0000249_abnormal_blood_vessel0.66121990
64MP0002928_abnormal_bile_duct0.63424259
65MP0000470_abnormal_stomach_morphology0.63244502
66MP0005025_abnormal_response_to0.61800602
67MP0001545_abnormal_hematopoietic_system0.60726526
68MP0005397_hematopoietic_system_phenotyp0.60726526
69MP0005551_abnormal_eye_electrophysiolog0.60449147
70MP0004484_altered_response_of0.58824690
71MP0005367_renal/urinary_system_phenotyp0.58576527
72MP0000516_abnormal_urinary_system0.58576527
73MP0009278_abnormal_bone_marrow0.57366628
74MP0001533_abnormal_skeleton_physiology0.56932057
75MP0005166_decreased_susceptibility_to0.56275161
76MP0000703_abnormal_thymus_morphology0.56052318
77MP0000955_abnormal_spinal_cord0.55508117
78MP0002653_abnormal_ependyma_morphology0.55209991
79MP0005535_abnormal_body_temperature0.55134262
80MP0005636_abnormal_mineral_homeostasis0.54580648
81MP0002452_abnormal_antigen_presenting0.54478451
82MP0005000_abnormal_immune_tolerance0.54063810
83MP0003172_abnormal_lysosome_physiology0.53353339
84MP0001970_abnormal_pain_threshold0.52250017
85MP0005375_adipose_tissue_phenotype0.52069598
86MP0001905_abnormal_dopamine_level0.51883657
87MP0005647_abnormal_sex_gland0.51570548
88MP0001879_abnormal_lymphatic_vessel0.50725090
89MP0000049_abnormal_middle_ear0.49324818
90MP0001873_stomach_inflammation0.49030689
91MP0003183_abnormal_peptide_metabolism0.47939422
92MP0004085_abnormal_heartbeat0.46470193
93MP0002420_abnormal_adaptive_immunity0.46060719
94MP0001819_abnormal_immune_cell0.43894386
95MP0002722_abnormal_immune_system0.43468507
96MP0005083_abnormal_biliary_tract0.42712527
97MP0008569_lethality_at_weaning0.42323090
98MP0002398_abnormal_bone_marrow0.42208614
99MP0001440_abnormal_grooming_behavior0.42188819
100MP0001501_abnormal_sleep_pattern0.41366794

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.03979429
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.12898695
3Absent/shortened dynein arms (HP:0200106)6.12898695
4Asymmetric septal hypertrophy (HP:0001670)5.39914608
5Attenuation of retinal blood vessels (HP:0007843)5.14913404
6Bony spicule pigmentary retinopathy (HP:0007737)4.74305947
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.65998852
8Abnormal ciliary motility (HP:0012262)4.42506805
9Resting tremor (HP:0002322)4.37923252
10Tubulointerstitial nephritis (HP:0001970)4.37541443
11Nasal polyposis (HP:0100582)4.32965840
12Abnormal respiratory epithelium morphology (HP:0012253)4.29876891
13Abnormal respiratory motile cilium morphology (HP:0005938)4.29876891
14Abnormal respiratory motile cilium physiology (HP:0012261)4.23607144
15Abnormal rod and cone electroretinograms (HP:0008323)4.05992775
16Chronic hepatic failure (HP:0100626)4.04041357
17Hyperkalemia (HP:0002153)3.95801868
18Enlarged epiphyses (HP:0010580)3.92804096
19Abnormality of macular pigmentation (HP:0008002)3.85739305
20Infertility (HP:0000789)3.79155640
21Potter facies (HP:0002009)3.76338310
22Facial shape deformation (HP:0011334)3.76338310
23Cone-rod dystrophy (HP:0000548)3.57896978
24Male infertility (HP:0003251)3.56039054
25Bell-shaped thorax (HP:0001591)3.55958325
26Azoospermia (HP:0000027)3.54275848
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.51025453
28Abnormal spermatogenesis (HP:0008669)3.48339273
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.43044235
30Unilateral renal agenesis (HP:0000122)3.42014011
31Abnormality of the nasal mucosa (HP:0000433)3.41394699
32Hypoplastic ischia (HP:0003175)3.38226694
33Abnormality of the costochondral junction (HP:0000919)3.04263059
34Impulsivity (HP:0100710)3.04001080
35Postural instability (HP:0002172)2.98783712
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.89671824
37Abnormality of the ischium (HP:0003174)2.85602910
38Hypoplasia of the thymus (HP:0000778)2.85413874
39Amelogenesis imperfecta (HP:0000705)2.81722120
40Abnormal urine output (HP:0012590)2.77833356
41Double outlet right ventricle (HP:0001719)2.66372021
42Congenital malformation of the right heart (HP:0011723)2.66372021
43Progressive cerebellar ataxia (HP:0002073)2.64464639
44Generalized aminoaciduria (HP:0002909)2.61735442
45Nephronophthisis (HP:0000090)2.61682405
46Abnormality of the aortic arch (HP:0012303)2.61077365
47Renal dysplasia (HP:0000110)2.59632181
48Abnormality of dental color (HP:0011073)2.55578361
49Polydipsia (HP:0001959)2.48669315
50Abnormal drinking behavior (HP:0030082)2.48669315
51Stage 5 chronic kidney disease (HP:0003774)2.45561834
52Tetany (HP:0001281)2.41162818
53Recurrent pneumonia (HP:0006532)2.38241222
54Abnormality of potassium homeostasis (HP:0011042)2.37148439
55Truncal obesity (HP:0001956)2.35679714
56Abnormality of renal excretion (HP:0011036)2.34225609
57Portal hypertension (HP:0001409)2.32791061
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31167765
59Polyuria (HP:0000103)2.28521475
60Widely patent fontanelles and sutures (HP:0004492)2.24354537
61Abnormality of the renal medulla (HP:0100957)2.21404381
62Menstrual irregularities (HP:0000858)2.19398947
63Abnormality of the pubic bones (HP:0003172)2.17421794
64Rhinitis (HP:0012384)2.16032607
65Tubulointerstitial abnormality (HP:0001969)2.14453518
66Abnormality of the hepatic vasculature (HP:0006707)2.11347504
67Hypoalphalipoproteinemia (HP:0003233)2.11142605
68Osteomalacia (HP:0002749)2.09973202
69Ventricular tachycardia (HP:0004756)2.06392223
70Progressive sensorineural hearing impairment (HP:0000408)2.03692118
71Congenital sensorineural hearing impairment (HP:0008527)2.03672198
72Insulin-resistant diabetes mellitus (HP:0000831)2.03345636
73Hyperthyroidism (HP:0000836)2.03012528
74Bronchiectasis (HP:0002110)2.02446008
75Hypochromic microcytic anemia (HP:0004840)2.00774621
76Abnormality of the parathyroid morphology (HP:0011766)1.97848765
77Renal Fanconi syndrome (HP:0001994)1.97107693
78Abnormality of the epiphysis of the femoral head (HP:0010574)1.94963004
79Gingivitis (HP:0000230)1.91418924
80Decreased central vision (HP:0007663)1.90555331
81Epiphyseal dysplasia (HP:0002656)1.89503132
82Hyponatremia (HP:0002902)1.86280685
83Gastrointestinal infarctions (HP:0005244)1.84261123
84Chronic obstructive pulmonary disease (HP:0006510)1.82911112
85Obstructive lung disease (HP:0006536)1.82911112
86Abnormal ventriculo-arterial connection (HP:0011563)1.81457322
87Transposition of the great arteries (HP:0001669)1.81457322
88Abnormal connection of the cardiac segments (HP:0011545)1.81457322
89Short ribs (HP:0000773)1.78016756
90Optic nerve hypoplasia (HP:0000609)1.77860027
91Flattened epiphyses (HP:0003071)1.76424838
92Abnormality of femoral epiphyses (HP:0006499)1.76111598
93Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.76111598
94Absent epiphyses (HP:0010577)1.75614808
95Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75614808
96Abnormality of chloride homeostasis (HP:0011422)1.73447634
97Photophobia (HP:0000613)1.72728952
98Abnormality of the femoral head (HP:0003368)1.72722290
99Aplasia/Hypoplasia of the thymus (HP:0010515)1.70432457
100Amblyopia (HP:0000646)1.69054576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.20772571
2TESK15.46558401
3DDR24.54109345
4INSRR3.72211111
5BRD43.25278270
6MAP4K22.82567978
7STK382.74304235
8PLK22.58587288
9MAPK152.34404413
10PNCK1.94362472
11PIK3CG1.93264796
12PRKD31.92782171
13WNK11.76023972
14CAMK1G1.72056226
15RIPK41.64084442
16DYRK1B1.61629053
17PDK11.61161257
18CDK121.59985679
19PDPK11.59192094
20STK38L1.51738543
21PTK2B1.46804210
22TXK1.44464552
23BLK1.43092073
24MAP3K111.39267412
25KSR21.30051597
26CDK71.27468954
27AKT31.25447828
28SIK21.21969705
29MAP3K21.07971997
30MST1R0.96850997
31MAP4K10.96813533
32PRKG20.91347364
33NEK60.86885384
34MAP2K20.81518824
35UHMK10.79005668
36MAP3K10.77104884
37GRK60.73685235
38PRKAA20.72988917
39JAK30.72608257
40RPS6KA10.70284913
41CDK30.67349193
42MAP3K90.66436731
43IKBKB0.64750616
44PRKG10.64722331
45BRAF0.64046030
46CAMK10.57979537
47SGK4940.57973997
48SGK2230.57973997
49CAMK1D0.55369448
50MAP2K30.54953174
51RPS6KA20.54153239
52SYK0.53842729
53PASK0.52370971
54CDK40.50058574
55WNK40.49887334
56RPS6KL10.48403160
57RPS6KC10.48403160
58IRAK40.48308400
59TYRO30.48256278
60RPS6KA60.45856886
61CAMK40.45119210
62MAP3K80.45030586
63SGK20.44596296
64TESK20.39955109
65MAPK10.39937204
66MAP3K30.39258338
67TAOK30.39143313
68MARK30.38595915
69ZAK0.38483615
70MARK20.37827517
71SGK10.37524352
72MAPK80.36869208
73MUSK0.36842278
74IKBKE0.36775073
75NTRK30.36192629
76TAOK10.35893362
77TNK20.35792852
78MAP3K70.34164563
79CDK20.33627489
80GSK3B0.33456908
81FES0.32725096
82CSK0.32517231
83SGK30.30637763
84PRKCZ0.30087499
85ZAP700.29980529
86JAK20.29411845
87TLK10.29017077
88HCK0.28932515
89CHUK0.27678938
90BTK0.26748241
91STK110.25417308
92LYN0.24914910
93CDK10.24446408
94DYRK30.23714119
95AKT10.23073396
96GRK70.22215650
97TEC0.22116793
98ROCK10.21463839
99MAP3K130.21438843
100ADRBK20.19535192

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.35750010
2Fatty acid biosynthesis_Homo sapiens_hsa000615.20047104
3Olfactory transduction_Homo sapiens_hsa047403.69099174
4Allograft rejection_Homo sapiens_hsa053302.79922256
5Graft-versus-host disease_Homo sapiens_hsa053322.71279969
6Autoimmune thyroid disease_Homo sapiens_hsa053202.67531415
7Type I diabetes mellitus_Homo sapiens_hsa049402.63418091
8Antigen processing and presentation_Homo sapiens_hsa046122.15745638
9Dorso-ventral axis formation_Homo sapiens_hsa043201.94292710
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.93827939
11Butanoate metabolism_Homo sapiens_hsa006501.91746119
12Taste transduction_Homo sapiens_hsa047421.67410193
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64248890
14Viral myocarditis_Homo sapiens_hsa054161.63081771
15Type II diabetes mellitus_Homo sapiens_hsa049301.61061779
16Influenza A_Homo sapiens_hsa051641.32962297
17Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16366617
18Inositol phosphate metabolism_Homo sapiens_hsa005621.15878874
19Adipocytokine signaling pathway_Homo sapiens_hsa049201.11816331
20B cell receptor signaling pathway_Homo sapiens_hsa046621.09596927
21Acute myeloid leukemia_Homo sapiens_hsa052211.08858387
22Morphine addiction_Homo sapiens_hsa050321.08297311
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06506230
24Endocytosis_Homo sapiens_hsa041441.06371593
25Leishmaniasis_Homo sapiens_hsa051401.06351303
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05617655
27Osteoclast differentiation_Homo sapiens_hsa043801.04434093
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03998682
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03903872
30Intestinal immune network for IgA production_Homo sapiens_hsa046720.98905502
31RNA transport_Homo sapiens_hsa030130.96873900
32Maturity onset diabetes of the young_Homo sapiens_hsa049500.92986205
33Phenylalanine metabolism_Homo sapiens_hsa003600.90409360
34Salivary secretion_Homo sapiens_hsa049700.89621652
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88120700
36Chemokine signaling pathway_Homo sapiens_hsa040620.87656151
37cAMP signaling pathway_Homo sapiens_hsa040240.85889086
38Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82282206
39Herpes simplex infection_Homo sapiens_hsa051680.82256363
40Jak-STAT signaling pathway_Homo sapiens_hsa046300.81177749
41Phototransduction_Homo sapiens_hsa047440.79085904
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77786503
43Legionellosis_Homo sapiens_hsa051340.75675728
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73942567
45Calcium signaling pathway_Homo sapiens_hsa040200.73425078
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73414859
47Viral carcinogenesis_Homo sapiens_hsa052030.72857838
48Circadian entrainment_Homo sapiens_hsa047130.71902428
49MAPK signaling pathway_Homo sapiens_hsa040100.71838375
50T cell receptor signaling pathway_Homo sapiens_hsa046600.71548843
51Toxoplasmosis_Homo sapiens_hsa051450.70976734
52Fatty acid degradation_Homo sapiens_hsa000710.65685859
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63596431
54VEGF signaling pathway_Homo sapiens_hsa043700.62990683
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62938526
56Glycerolipid metabolism_Homo sapiens_hsa005610.62124331
57ABC transporters_Homo sapiens_hsa020100.60633756
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57643419
59Cardiac muscle contraction_Homo sapiens_hsa042600.57559051
60Arginine and proline metabolism_Homo sapiens_hsa003300.57538874
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56406294
62Arginine biosynthesis_Homo sapiens_hsa002200.56386257
63Measles_Homo sapiens_hsa051620.54848503
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.54825236
65Hedgehog signaling pathway_Homo sapiens_hsa043400.53890679
66Staphylococcus aureus infection_Homo sapiens_hsa051500.53856808
67Regulation of autophagy_Homo sapiens_hsa041400.53434908
68Fat digestion and absorption_Homo sapiens_hsa049750.53305859
69Malaria_Homo sapiens_hsa051440.53094913
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52735703
71Estrogen signaling pathway_Homo sapiens_hsa049150.52127600
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50889341
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50806465
74Hematopoietic cell lineage_Homo sapiens_hsa046400.50322801
75Renin secretion_Homo sapiens_hsa049240.49306942
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49128215
77Serotonergic synapse_Homo sapiens_hsa047260.48810044
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47741311
79Oocyte meiosis_Homo sapiens_hsa041140.46034095
80Epstein-Barr virus infection_Homo sapiens_hsa051690.45776273
81Fatty acid metabolism_Homo sapiens_hsa012120.44858867
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44603677
83Protein digestion and absorption_Homo sapiens_hsa049740.42222193
84Purine metabolism_Homo sapiens_hsa002300.41375350
85African trypanosomiasis_Homo sapiens_hsa051430.40903967
86Cholinergic synapse_Homo sapiens_hsa047250.40232299
87Renin-angiotensin system_Homo sapiens_hsa046140.39873450
88Platelet activation_Homo sapiens_hsa046110.38617853
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38154193
90Synaptic vesicle cycle_Homo sapiens_hsa047210.37814662
91TNF signaling pathway_Homo sapiens_hsa046680.36694208
92Non-small cell lung cancer_Homo sapiens_hsa052230.35420550
93Primary immunodeficiency_Homo sapiens_hsa053400.34389986
94Nitrogen metabolism_Homo sapiens_hsa009100.33733881
95Nicotine addiction_Homo sapiens_hsa050330.33420992
96Prolactin signaling pathway_Homo sapiens_hsa049170.33216471
97Tuberculosis_Homo sapiens_hsa051520.33210608
98Glutamatergic synapse_Homo sapiens_hsa047240.32781279
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.31267736
100Alcoholism_Homo sapiens_hsa050340.30219234

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