FAM205BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.91517759
2DNA packaging (GO:0006323)9.52990359
3response to pheromone (GO:0019236)9.30160194
4sperm capacitation (GO:0048240)9.07255641
5single strand break repair (GO:0000012)8.80131531
6spermatid nucleus differentiation (GO:0007289)8.72107845
7plasma membrane fusion (GO:0045026)7.88758248
8spermatid development (GO:0007286)7.85697110
9microtubule depolymerization (GO:0007019)7.71842955
10sexual reproduction (GO:0019953)7.39112135
11sperm-egg recognition (GO:0035036)7.27021285
12protein targeting to Golgi (GO:0000042)7.16875170
13establishment of protein localization to Golgi (GO:0072600)6.97186160
14rRNA methylation (GO:0031167)6.95218418
15protein polyglutamylation (GO:0018095)6.94193147
16binding of sperm to zona pellucida (GO:0007339)6.77451756
17multicellular organism reproduction (GO:0032504)6.70798907
18microtubule polymerization or depolymerization (GO:0031109)6.68478014
19retrograde transport, vesicle recycling within Golgi (GO:0000301)6.68410376
20reproduction (GO:0000003)6.65520056
21calcium ion-dependent exocytosis (GO:0017156)6.49403311
22axonemal dynein complex assembly (GO:0070286)6.29360427
23negative regulation of inclusion body assembly (GO:0090084)6.20815222
24phosphatidylethanolamine biosynthetic process (GO:0006646)6.13689938
25spermatogenesis (GO:0007283)6.13455809
26male gamete generation (GO:0048232)6.11371204
27cell-cell recognition (GO:0009988)5.97026731
28rRNA modification (GO:0000154)5.87563054
29phosphatidylethanolamine metabolic process (GO:0046337)5.68691635
30gamete generation (GO:0007276)5.59312577
31microtubule severing (GO:0051013)5.53204505
32centriole replication (GO:0007099)5.53076154
33cellular ketone body metabolic process (GO:0046950)5.48786751
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44247749
35chromatin silencing (GO:0006342)5.26182565
36positive regulation of Rab GTPase activity (GO:0032851)5.17078211
37regulation of Rab GTPase activity (GO:0032313)5.17078211
38motile cilium assembly (GO:0044458)5.15860575
39protein localization to Golgi apparatus (GO:0034067)5.15666107
40regulation of cilium movement (GO:0003352)5.08959254
41cilium or flagellum-dependent cell motility (GO:0001539)4.99914908
42single fertilization (GO:0007338)4.84386250
43centriole assembly (GO:0098534)4.83733048
44ketone body metabolic process (GO:1902224)4.83607987
45regulation of centriole replication (GO:0046599)4.63587626
46RNA destabilization (GO:0050779)4.61085239
47germ cell development (GO:0007281)4.53381800
48multicellular organismal reproductive process (GO:0048609)4.47958105
49cell wall macromolecule catabolic process (GO:0016998)4.40638647
50cell wall macromolecule metabolic process (GO:0044036)4.34408935
51regulation of inclusion body assembly (GO:0090083)4.34346670
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.32544054
53nucleus organization (GO:0006997)4.32406164
54seminiferous tubule development (GO:0072520)4.31249362
55regulation of transcription involved in cell fate commitment (GO:0060850)4.19122817
56fertilization (GO:0009566)4.09768318
57epithelial cilium movement (GO:0003351)4.03526465
58musculoskeletal movement (GO:0050881)3.85027788
59multicellular organismal movement (GO:0050879)3.85027788
60coenzyme catabolic process (GO:0009109)3.83483643
61glycerol ether metabolic process (GO:0006662)3.82914796
62negative regulation of Rho protein signal transduction (GO:0035024)3.82472883
63glomerular visceral epithelial cell development (GO:0072015)3.66688579
64cilium movement (GO:0003341)3.61647696
65negative regulation of gene expression, epigenetic (GO:0045814)3.59956098
66ether metabolic process (GO:0018904)3.52815885
67protein-DNA complex disassembly (GO:0032986)3.52121753
68nucleosome disassembly (GO:0006337)3.52121753
69glomerular epithelial cell development (GO:0072310)3.50470069
70microtubule nucleation (GO:0007020)3.44913414
71cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.42099620
72organic cation transport (GO:0015695)3.38785174
73regulation of microtubule-based movement (GO:0060632)3.33336857
74histone H3-K9 demethylation (GO:0033169)3.28573013
75regulation of interleukin-13 production (GO:0032656)3.23412243
76polyamine biosynthetic process (GO:0006596)3.23260957
77regulation of T-helper 2 cell differentiation (GO:0045628)3.10422170
78cellular response to pH (GO:0071467)3.09959628
79homeostasis of number of cells within a tissue (GO:0048873)3.08024548
80cerebral cortex neuron differentiation (GO:0021895)3.06992025
81response to acidic pH (GO:0010447)3.05888019
82DNA conformation change (GO:0071103)3.04819506
83cranial nerve morphogenesis (GO:0021602)3.00991929
84mesenchymal cell differentiation involved in kidney development (GO:0072161)2.99299469
85mesenchymal cell differentiation involved in renal system development (GO:2001012)2.99299469
86multicellular organismal development (GO:0007275)2.98794739
87peptidyl-threonine dephosphorylation (GO:0035970)2.96107881
88NAD biosynthetic process (GO:0009435)2.94856264
89cell recognition (GO:0008037)2.91086396
90protein depolymerization (GO:0051261)2.90692096
91receptor recycling (GO:0001881)2.90583363
92regulation of somitogenesis (GO:0014807)2.89999312
93cell differentiation involved in metanephros development (GO:0072202)2.83760178
94negative regulation of histone methylation (GO:0031061)2.81892412
95regulation of ARF GTPase activity (GO:0032312)2.77180247
96regulation of phosphoprotein phosphatase activity (GO:0043666)2.75514192
97membrane protein intracellular domain proteolysis (GO:0031293)2.72923383
98acrosome reaction (GO:0007340)11.9744284
99sperm motility (GO:0030317)11.7180561
100fusion of sperm to egg plasma membrane (GO:0007342)10.4242174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.32389830
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.22454132
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.42251692
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43982688
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.43982688
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24836923
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.19101339
8CBP_20019798_ChIP-Seq_JUKART_Human2.19101339
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11609793
10DROSHA_22980978_ChIP-Seq_HELA_Human2.04841484
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.04604478
12EZH2_22144423_ChIP-Seq_EOC_Human2.03164522
13ERA_21632823_ChIP-Seq_H3396_Human1.98027790
14ELF1_20517297_ChIP-Seq_JURKAT_Human1.90485464
15FUS_26573619_Chip-Seq_HEK293_Human1.86536647
16EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.86276177
17RAC3_21632823_ChIP-Seq_H3396_Human1.83720045
18WDR5_24793694_ChIP-Seq_LNCAP_Human1.83202318
19NANOG_20526341_ChIP-Seq_ESCs_Human1.75195243
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72999070
21ER_23166858_ChIP-Seq_MCF-7_Human1.72768935
22RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.69942830
23EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.69934342
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67307138
25CTCF_27219007_Chip-Seq_Bcells_Human1.64160921
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.56223407
27BCL6_27268052_Chip-Seq_Bcells_Human1.55547812
28TAF2_19829295_ChIP-Seq_ESCs_Human1.54632036
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54523061
30SMC4_20622854_ChIP-Seq_HELA_Human1.54391815
31MYC_19829295_ChIP-Seq_ESCs_Human1.50873818
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.50015548
33SMAD4_21741376_ChIP-Seq_EPCs_Human1.48546468
34E2F1_20622854_ChIP-Seq_HELA_Human1.48072543
35TDRD3_21172665_ChIP-Seq_MCF-7_Human1.48012019
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46761807
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46743581
38CTCF_20526341_ChIP-Seq_ESCs_Human1.46124866
39TP63_22573176_ChIP-Seq_HFKS_Human1.45806131
40BCOR_27268052_Chip-Seq_Bcells_Human1.45166646
41OCT4_20526341_ChIP-Seq_ESCs_Human1.44625363
42AR_25329375_ChIP-Seq_VCAP_Human1.44342506
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.44119141
44P68_20966046_ChIP-Seq_HELA_Human1.43570490
45PHF8_20622854_ChIP-Seq_HELA_Human1.41647749
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.41618633
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39149692
48CBX2_22325352_ChIP-Seq_293T-Rex_Human1.38308428
49TP53_18474530_ChIP-ChIP_U2OS_Human1.37398242
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36434797
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.36163324
52RBPJ_21746931_ChIP-Seq_IB4_Human1.34732929
53CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33069166
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32844569
55ERG_20517297_ChIP-Seq_VCAP_Human1.31187943
56SMAD3_21741376_ChIP-Seq_ESCs_Human1.30771050
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.30611317
58ETV1_20927104_ChIP-Seq_GIST48_Human1.29145004
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28998581
60P300_19829295_ChIP-Seq_ESCs_Human1.28774876
61P300_27268052_Chip-Seq_Bcells_Human1.28015011
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.27961664
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27166950
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27130130
65CEBPB_22108803_ChIP-Seq_LS180_Human1.26639583
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26479748
67TAF15_26573619_Chip-Seq_HEK293_Human1.25630879
68LXR_22292898_ChIP-Seq_THP-1_Human1.24876264
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22303826
70NFYB_21822215_ChIP-Seq_K562_Human1.22077720
71TBL1_22424771_ChIP-Seq_293T_Human1.21819022
72KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19161248
73SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17927570
74ZNF274_21170338_ChIP-Seq_K562_Hela1.16909425
75SMAD4_21741376_ChIP-Seq_HESCs_Human1.16793998
76P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.16118601
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.15953155
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15437389
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14015191
80RUNX_20019798_ChIP-Seq_JUKART_Human1.13652430
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12985825
82PHF8_20622853_ChIP-Seq_HELA_Human1.12952672
83AR_21572438_ChIP-Seq_LNCaP_Human1.12426578
84P53_21459846_ChIP-Seq_SAOS-2_Human1.12391523
85SMRT_27268052_Chip-Seq_Bcells_Human1.12332781
86SA1_27219007_Chip-Seq_Bcells_Human1.10490375
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09999200
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09816916
89RUNX2_22187159_ChIP-Seq_PCA_Human1.09506659
90GATA6_21074721_ChIP-Seq_CACO-2_Human1.07896227
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.06788008
92SMAD4_21799915_ChIP-Seq_A2780_Human1.06313245
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04432396
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04192133
95NFYA_21822215_ChIP-Seq_K562_Human1.03930588
96STAT3_23295773_ChIP-Seq_U87_Human1.03136410
97OCT1_27270436_Chip-Seq_PROSTATE_Human1.03006644
98RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02388021
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.01054597
100NANOG_19829295_ChIP-Seq_ESCs_Human1.00414141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.40546980
2MP0003878_abnormal_ear_physiology5.40546980
3MP0005670_abnormal_white_adipose4.63153535
4MP0003698_abnormal_male_reproductive4.33513321
5MP0001348_abnormal_lacrimal_gland4.16235880
6MP0001929_abnormal_gametogenesis3.71076111
7MP0000678_abnormal_parathyroid_gland2.53595689
8MP0002161_abnormal_fertility/fecundity2.38588558
9MP0005379_endocrine/exocrine_gland_phen2.14381905
10MP0002132_abnormal_respiratory_system2.12756399
11MP0003011_delayed_dark_adaptation2.10048452
12MP0003646_muscle_fatigue2.08875079
13MP0003718_maternal_effect2.02642025
14MP0005410_abnormal_fertilization12.1857943
15MP0001485_abnormal_pinna_reflex1.83046887
16MP0002249_abnormal_larynx_morphology1.68398226
17MP0002210_abnormal_sex_determination1.59447814
18MP0001486_abnormal_startle_reflex1.58434857
19MP0005423_abnormal_somatic_nervous1.57741863
20MP0002234_abnormal_pharynx_morphology1.53528739
21MP0002282_abnormal_trachea_morphology1.49026844
22MP0009053_abnormal_anal_canal1.47718480
23MP0005310_abnormal_salivary_gland1.36240828
24MP0003879_abnormal_hair_cell1.35215600
25MP0004742_abnormal_vestibular_system1.32400289
26MP0001145_abnormal_male_reproductive1.31228579
27MP0002735_abnormal_chemical_nociception1.29240555
28MP0004510_myositis1.25516852
29MP0000653_abnormal_sex_gland1.25067265
30MP0002138_abnormal_hepatobiliary_system1.23631741
31MP0001968_abnormal_touch/_nociception1.21534527
32MP0001765_abnormal_ion_homeostasis1.15378083
33MP0002127_abnormal_cardiovascular_syste1.15370860
34MP0000534_abnormal_ureter_morphology1.14706834
35MP0005451_abnormal_body_composition1.11921893
36MP0001963_abnormal_hearing_physiology1.09129087
37MP0004859_abnormal_synaptic_plasticity1.08574413
38MP0005248_abnormal_Harderian_gland1.05874531
39MP0002822_catalepsy1.00661207
40MP0005395_other_phenotype0.98778040
41MP0000026_abnormal_inner_ear0.97731267
42MP0005666_abnormal_adipose_tissue0.88866453
43MP0005551_abnormal_eye_electrophysiolog0.87943482
44MP0002229_neurodegeneration0.86744307
45MP0009115_abnormal_fat_cell0.81177602
46MP0006292_abnormal_olfactory_placode0.80831021
47MP0005083_abnormal_biliary_tract0.79370049
48MP0000681_abnormal_thyroid_gland0.79054793
49MP0000955_abnormal_spinal_cord0.78520019
50MP0002733_abnormal_thermal_nociception0.77869680
51MP0002067_abnormal_sensory_capabilities0.76131799
52MP0004085_abnormal_heartbeat0.72706961
53MP0008877_abnormal_DNA_methylation0.72295213
54MP0000049_abnormal_middle_ear0.71164329
55MP0005375_adipose_tissue_phenotype0.67482119
56MP0002557_abnormal_social/conspecific_i0.66499889
57MP0004233_abnormal_muscle_weight0.64617413
58MP0005253_abnormal_eye_physiology0.63792398
59MP0008569_lethality_at_weaning0.62120453
60MP0001879_abnormal_lymphatic_vessel0.61204937
61MP0005167_abnormal_blood-brain_barrier0.59843770
62MP0002572_abnormal_emotion/affect_behav0.59533107
63MP0001666_abnormal_nutrient_absorption0.58043100
64MP0005367_renal/urinary_system_phenotyp0.56982265
65MP0000516_abnormal_urinary_system0.56982265
66MP0005636_abnormal_mineral_homeostasis0.55237776
67MP0001501_abnormal_sleep_pattern0.54971122
68MP0005535_abnormal_body_temperature0.54748173
69MP0001970_abnormal_pain_threshold0.52284638
70MP0001984_abnormal_olfaction0.50977988
71MP0009745_abnormal_behavioral_response0.50671914
72MP0008961_abnormal_basal_metabolism0.49591492
73MP0001905_abnormal_dopamine_level0.49389710
74MP0005623_abnormal_meninges_morphology0.48344418
75MP0009697_abnormal_copulation0.48133011
76MP0004036_abnormal_muscle_relaxation0.45599615
77MP0000230_abnormal_systemic_arterial0.44640603
78MP0002272_abnormal_nervous_system0.44445781
79MP0003136_yellow_coat_color0.44285117
80MP0004484_altered_response_of0.44218089
81MP0003880_abnormal_central_pattern0.43618284
82MP0001440_abnormal_grooming_behavior0.43396167
83MP0000003_abnormal_adipose_tissue0.42744581
84MP0008995_early_reproductive_senescence0.42537103
85MP0003077_abnormal_cell_cycle0.42337681
86MP0002928_abnormal_bile_duct0.41312044
87MP0003137_abnormal_impulse_conducting0.40031589
88MP0002734_abnormal_mechanical_nocicepti0.38555379
89MP0000470_abnormal_stomach_morphology0.37992467
90MP0000249_abnormal_blood_vessel0.37386543
91MP0006276_abnormal_autonomic_nervous0.36353517
92MP0002653_abnormal_ependyma_morphology0.35788502
93MP0003635_abnormal_synaptic_transmissio0.35241658
94MP0003119_abnormal_digestive_system0.34707501
95MP0005084_abnormal_gallbladder_morpholo0.33406360
96MP0002168_other_aberrant_phenotype0.33318436
97MP0005391_vision/eye_phenotype0.32241603
98MP0003699_abnormal_female_reproductive0.31560555
99MP0005647_abnormal_sex_gland0.31118142
100MP0002882_abnormal_neuron_morphology0.30502395

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.27210006
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.44326421
3Absent/shortened dynein arms (HP:0200106)6.44326421
4Asymmetric septal hypertrophy (HP:0001670)5.49605434
5Bony spicule pigmentary retinopathy (HP:0007737)5.27740017
6Attenuation of retinal blood vessels (HP:0007843)5.26887181
7Abnormal ciliary motility (HP:0012262)4.95859393
8Tubulointerstitial nephritis (HP:0001970)4.95180963
9Abnormal respiratory motile cilium physiology (HP:0012261)4.74020451
10Chronic hepatic failure (HP:0100626)4.65423003
11Abnormal respiratory motile cilium morphology (HP:0005938)4.55196431
12Abnormal respiratory epithelium morphology (HP:0012253)4.55196431
13Nasal polyposis (HP:0100582)4.44793600
14Hyperkalemia (HP:0002153)4.37577217
15Resting tremor (HP:0002322)4.25377976
16Male infertility (HP:0003251)4.17327734
17Abnormality of macular pigmentation (HP:0008002)4.16895752
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.16091944
19Infertility (HP:0000789)4.10816118
20Facial shape deformation (HP:0011334)3.94598956
21Potter facies (HP:0002009)3.94598956
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.90733878
23Cone-rod dystrophy (HP:0000548)3.78259932
24Abnormal rod and cone electroretinograms (HP:0008323)3.77700115
25Bell-shaped thorax (HP:0001591)3.68574544
26Abnormality of the nasal mucosa (HP:0000433)3.61153146
27Aplasia/Hypoplasia of the earlobes (HP:0009906)3.57583946
28Hypoplastic ischia (HP:0003175)3.48260459
29Abnormal spermatogenesis (HP:0008669)3.23216371
30Impulsivity (HP:0100710)3.20349471
31Enlarged epiphyses (HP:0010580)3.20150997
32Azoospermia (HP:0000027)3.12502567
33Abnormality of the ischium (HP:0003174)3.10861441
34Hypoplasia of the thymus (HP:0000778)3.05885700
35Progressive cerebellar ataxia (HP:0002073)3.03264512
36Postural instability (HP:0002172)2.97869089
37Amelogenesis imperfecta (HP:0000705)2.96304502
38Progressive sensorineural hearing impairment (HP:0000408)2.89539195
39Unilateral renal agenesis (HP:0000122)2.87927529
40Abnormal urine output (HP:0012590)2.87046389
41Stage 5 chronic kidney disease (HP:0003774)2.80195580
42Hypoalphalipoproteinemia (HP:0003233)2.80111583
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.79224402
44Abnormality of dental color (HP:0011073)2.73861963
45Abnormality of the aortic arch (HP:0012303)2.72226501
46Rhinitis (HP:0012384)2.67796132
47Generalized aminoaciduria (HP:0002909)2.65900011
48Congenital malformation of the right heart (HP:0011723)2.58611481
49Double outlet right ventricle (HP:0001719)2.58611481
50Renal dysplasia (HP:0000110)2.58512918
51Nephronophthisis (HP:0000090)2.58284889
52Truncal obesity (HP:0001956)2.58223656
53Abnormality of potassium homeostasis (HP:0011042)2.57206882
54Polydipsia (HP:0001959)2.52906546
55Abnormal drinking behavior (HP:0030082)2.52906546
56Portal hypertension (HP:0001409)2.46973157
57Abnormality of renal excretion (HP:0011036)2.46239980
58Tubulointerstitial abnormality (HP:0001969)2.41503491
59Polyuria (HP:0000103)2.36803572
60Renovascular hypertension (HP:0100817)2.31382430
61Abnormality of the costochondral junction (HP:0000919)2.29517966
62Insulin-resistant diabetes mellitus (HP:0000831)2.28227968
63Abnormality of the hepatic vasculature (HP:0006707)2.25087012
64Menstrual irregularities (HP:0000858)2.23194048
65Abnormality of the renal medulla (HP:0100957)2.23165589
66Ventricular tachycardia (HP:0004756)2.23100005
67Optic nerve hypoplasia (HP:0000609)2.18332595
68Abnormality of the parathyroid morphology (HP:0011766)2.12374851
69Bronchiectasis (HP:0002110)2.07936510
70Focal segmental glomerulosclerosis (HP:0000097)2.05824831
71Decreased central vision (HP:0007663)2.04014669
72Tetany (HP:0001281)2.01598391
73Flattened epiphyses (HP:0003071)1.96425836
74Hyponatremia (HP:0002902)1.95751241
75Intellectual disability, moderate (HP:0002342)1.95654260
76Chronic bronchitis (HP:0004469)1.94839778
77Widely patent fontanelles and sutures (HP:0004492)1.90804996
78Osteomalacia (HP:0002749)1.87672291
79Epiphyseal dysplasia (HP:0002656)1.87440177
80Congenital sensorineural hearing impairment (HP:0008527)1.86473642
81Hyperuricemia (HP:0002149)1.86136974
82Increased purine levels (HP:0004368)1.86136974
83Myokymia (HP:0002411)1.85451933
84Hypophosphatemic rickets (HP:0004912)1.85102852
85Sensory axonal neuropathy (HP:0003390)1.84886399
86Progressive hearing impairment (HP:0001730)1.81138850
87Bradycardia (HP:0001662)1.80392754
88Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80074795
89Pendular nystagmus (HP:0012043)1.80021292
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79947611
91Abnormality of the pubic bones (HP:0003172)1.79830020
92Abnormality of the epiphysis of the femoral head (HP:0010574)1.79384690
93Neoplasm of the heart (HP:0100544)1.79075610
94Hyperthyroidism (HP:0000836)1.77520792
95Hypoparathyroidism (HP:0000829)1.76342451
96Recurrent corneal erosions (HP:0000495)1.75932635
97Flat capital femoral epiphysis (HP:0003370)1.74709553
98Photophobia (HP:0000613)1.71554832
99Abnormal ventriculo-arterial connection (HP:0011563)1.70223560
100Abnormal connection of the cardiac segments (HP:0011545)1.70223560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.75797912
2TESK15.68700163
3INSRR4.43421908
4DDR24.18675976
5MAP4K23.45573235
6BRD43.37375909
7PLK23.25881353
8STK383.05650908
9PNCK2.85597331
10CAMK1G2.37671829
11PIK3CG2.09876964
12MAPK152.08880027
13PRKD32.01560473
14STK38L2.01209808
15WNK11.84443114
16MST1R1.72354716
17PDPK11.63717040
18PDK11.59031273
19CDK121.56844573
20PTK2B1.30728033
21DYRK1B1.26554105
22NEK61.19021039
23CDK71.17414271
24LATS11.11911393
25MAP3K91.01992856
26LATS20.98641479
27CAMK1D0.98271373
28TYRO30.94983689
29AKT30.88098252
30KSR20.86784504
31SIK20.82774125
32PRKG20.77262180
33PRKAA20.72861972
34UHMK10.70294988
35PRKG10.68907458
36WNK40.66430283
37MAP3K110.63161352
38BRAF0.62430394
39RPS6KA20.58424965
40FRK0.57339847
41CDK30.56898658
42CAMK10.55781881
43MAP2K20.54678962
44RPS6KA10.53939955
45BMPR1B0.50433458
46NTRK30.48404728
47STK390.48067440
48MUSK0.46454235
49TIE10.45709190
50GSK3B0.45454360
51SGK2230.44858641
52SGK4940.44858641
53MAP3K20.44405791
54ROCK10.44107271
55PRKCG0.42499258
56MARK10.42005975
57MAPK10.41924857
58CDK20.40624176
59CDK10.40383498
60MTOR0.39432668
61MAP3K80.39373192
62CAMK40.35090943
63CDK40.34404431
64MAPK80.33351760
65OXSR10.32612322
66RPS6KA60.31385550
67RPS6KL10.31333656
68RPS6KC10.31333656
69SGK10.30554895
70PRKCZ0.30339653
71PRKCB0.26139496
72CHEK10.26124091
73MAP3K10.25529399
74BLK0.25102619
75MAPK140.23779926
76TNIK0.23289658
77MAPK100.23243487
78MET0.22293901
79MAP3K40.22060931
80TESK20.20289557
81NEK20.19206993
82AKT10.18922341
83PKN10.18389408
84FER0.18248426
85MAP3K70.17656548
86MARK20.16289526
87PRKACB0.15903141
88MAPK110.15246536
89RIPK40.13337350
90PRKCE0.12531300
91SGK20.12483327
92BRSK10.11651168
93NME10.10976027
94PRKACA0.10928695
95ARAF0.10810043
96PRKAA10.09926403
97ADRBK20.09597126
98CAMK2A0.08562079
99IKBKB0.08342859
100RPS6KA30.07360987

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.45165458
2Fatty acid biosynthesis_Homo sapiens_hsa000615.61336872
3Olfactory transduction_Homo sapiens_hsa047403.88975328
4Butanoate metabolism_Homo sapiens_hsa006502.74714171
5Taste transduction_Homo sapiens_hsa047422.15268488
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.00989801
7Graft-versus-host disease_Homo sapiens_hsa053321.96767080
8Allograft rejection_Homo sapiens_hsa053301.90562945
9Type I diabetes mellitus_Homo sapiens_hsa049401.86750671
10Autoimmune thyroid disease_Homo sapiens_hsa053201.85459170
11Antigen processing and presentation_Homo sapiens_hsa046121.83548898
12Dorso-ventral axis formation_Homo sapiens_hsa043201.65963257
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58078486
14Type II diabetes mellitus_Homo sapiens_hsa049301.55576651
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45323114
16Fatty acid degradation_Homo sapiens_hsa000711.40886614
17Phenylalanine metabolism_Homo sapiens_hsa003601.36323594
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34706164
19Viral myocarditis_Homo sapiens_hsa054161.33938508
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31805607
21RNA transport_Homo sapiens_hsa030131.30017047
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.29237809
23Arginine and proline metabolism_Homo sapiens_hsa003301.22338853
24Phototransduction_Homo sapiens_hsa047441.13820407
25Fatty acid metabolism_Homo sapiens_hsa012121.13667809
26Salivary secretion_Homo sapiens_hsa049701.12669522
27Endocytosis_Homo sapiens_hsa041441.09674729
28Protein digestion and absorption_Homo sapiens_hsa049741.08530530
29Nicotine addiction_Homo sapiens_hsa050331.06018824
30Morphine addiction_Homo sapiens_hsa050321.04461712
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04289327
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01311691
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.00798469
34ABC transporters_Homo sapiens_hsa020100.99584152
35Calcium signaling pathway_Homo sapiens_hsa040200.99158512
36Cardiac muscle contraction_Homo sapiens_hsa042600.95480666
37Inositol phosphate metabolism_Homo sapiens_hsa005620.94789389
38cAMP signaling pathway_Homo sapiens_hsa040240.93131612
39Fat digestion and absorption_Homo sapiens_hsa049750.90450098
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84476331
41PPAR signaling pathway_Homo sapiens_hsa033200.83944104
42Circadian entrainment_Homo sapiens_hsa047130.83495341
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80621834
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.80450194
45Renin-angiotensin system_Homo sapiens_hsa046140.79968596
46Glycerolipid metabolism_Homo sapiens_hsa005610.77214317
47Retinol metabolism_Homo sapiens_hsa008300.75770357
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75497747
49Glutamatergic synapse_Homo sapiens_hsa047240.75169425
50Influenza A_Homo sapiens_hsa051640.73590968
51Estrogen signaling pathway_Homo sapiens_hsa049150.72064361
52Arginine biosynthesis_Homo sapiens_hsa002200.71928844
53Oocyte meiosis_Homo sapiens_hsa041140.71068171
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71013142
55Synaptic vesicle cycle_Homo sapiens_hsa047210.68512713
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68048811
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67791609
58Tyrosine metabolism_Homo sapiens_hsa003500.67108842
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65488037
60Hedgehog signaling pathway_Homo sapiens_hsa043400.64142407
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.62238696
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62203792
63Renin secretion_Homo sapiens_hsa049240.60693951
64Serotonergic synapse_Homo sapiens_hsa047260.60180770
65Bile secretion_Homo sapiens_hsa049760.57742231
66Insulin secretion_Homo sapiens_hsa049110.55888797
67Gastric acid secretion_Homo sapiens_hsa049710.54563720
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54443485
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.51945723
70Pancreatic secretion_Homo sapiens_hsa049720.49241942
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48576253
72MAPK signaling pathway_Homo sapiens_hsa040100.47980782
73VEGF signaling pathway_Homo sapiens_hsa043700.47844939
74GABAergic synapse_Homo sapiens_hsa047270.45903007
75Nitrogen metabolism_Homo sapiens_hsa009100.45329830
76Tight junction_Homo sapiens_hsa045300.43346445
77Purine metabolism_Homo sapiens_hsa002300.41331970
78Cholinergic synapse_Homo sapiens_hsa047250.40273638
79ECM-receptor interaction_Homo sapiens_hsa045120.39203558
80Oxytocin signaling pathway_Homo sapiens_hsa049210.34337283
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34076345
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33893160
83Acute myeloid leukemia_Homo sapiens_hsa052210.33263287
84Selenocompound metabolism_Homo sapiens_hsa004500.31087287
85Linoleic acid metabolism_Homo sapiens_hsa005910.30411562
86Long-term potentiation_Homo sapiens_hsa047200.27294320
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.25740265
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.25674646
89Basal transcription factors_Homo sapiens_hsa030220.24935694
90mRNA surveillance pathway_Homo sapiens_hsa030150.20829157
91Viral carcinogenesis_Homo sapiens_hsa052030.20683223
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20318593
93Huntingtons disease_Homo sapiens_hsa050160.19568361
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19464662
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17202244
96Herpes simplex infection_Homo sapiens_hsa051680.17146439
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16815172
98Amphetamine addiction_Homo sapiens_hsa050310.15207078
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15160632
100Chemical carcinogenesis_Homo sapiens_hsa052040.13848499

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