FAM205A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.50257121
2sperm capacitation (GO:0048240)9.41420261
3response to pheromone (GO:0019236)9.18337213
4DNA packaging (GO:0006323)9.14303218
5plasma membrane fusion (GO:0045026)8.63609240
6single strand break repair (GO:0000012)8.45238308
7spermatid nucleus differentiation (GO:0007289)8.38098310
8microtubule depolymerization (GO:0007019)8.28886998
9spermatid development (GO:0007286)8.14233971
10sperm-egg recognition (GO:0035036)7.55074173
11multicellular organism reproduction (GO:0032504)7.13189152
12sexual reproduction (GO:0019953)7.09130473
13binding of sperm to zona pellucida (GO:0007339)7.01942681
14reproduction (GO:0000003)6.87163085
15microtubule polymerization or depolymerization (GO:0031109)6.83211125
16rRNA methylation (GO:0031167)6.81016726
17protein polyglutamylation (GO:0018095)6.76925623
18calcium ion-dependent exocytosis (GO:0017156)6.72833102
19negative regulation of inclusion body assembly (GO:0090084)6.67211046
20protein targeting to Golgi (GO:0000042)6.65090087
21establishment of protein localization to Golgi (GO:0072600)6.39921476
22phosphatidylethanolamine biosynthetic process (GO:0006646)6.32455884
23cell-cell recognition (GO:0009988)6.21650811
24retrograde transport, vesicle recycling within Golgi (GO:0000301)6.20419991
25axonemal dynein complex assembly (GO:0070286)6.19990721
26spermatogenesis (GO:0007283)6.09573669
27male gamete generation (GO:0048232)6.07455406
28phosphatidylethanolamine metabolic process (GO:0046337)5.84547829
29microtubule severing (GO:0051013)5.72853760
30rRNA modification (GO:0000154)5.69440508
31cellular ketone body metabolic process (GO:0046950)5.62011722
32gamete generation (GO:0007276)5.55338537
33centriole replication (GO:0007099)5.46103320
34positive regulation of Rab GTPase activity (GO:0032851)5.37773567
35regulation of Rab GTPase activity (GO:0032313)5.37773567
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.30940935
37regulation of cilium movement (GO:0003352)5.10948300
38single fertilization (GO:0007338)4.96152843
39ketone body metabolic process (GO:1902224)4.95425997
40motile cilium assembly (GO:0044458)4.93269177
41chromatin silencing (GO:0006342)4.82847143
42centriole assembly (GO:0098534)4.80857077
43protein localization to Golgi apparatus (GO:0034067)4.75455668
44regulation of inclusion body assembly (GO:0090083)4.75220024
45cilium or flagellum-dependent cell motility (GO:0001539)4.73896954
46regulation of transcription involved in cell fate commitment (GO:0060850)4.66314417
47germ cell development (GO:0007281)4.60946776
48RNA destabilization (GO:0050779)4.45916199
49multicellular organismal reproductive process (GO:0048609)4.45234279
50regulation of centriole replication (GO:0046599)4.42693269
51cellular process involved in reproduction in multicellular organism (GO:0022412)4.42311582
52cell wall macromolecule catabolic process (GO:0016998)4.31691228
53cell wall macromolecule metabolic process (GO:0044036)4.24001103
54nucleus organization (GO:0006997)4.17937956
55fertilization (GO:0009566)4.08505150
56seminiferous tubule development (GO:0072520)4.05383065
57coenzyme catabolic process (GO:0009109)3.98506935
58epithelial cilium movement (GO:0003351)3.95585474
59glycerol ether metabolic process (GO:0006662)3.75871042
60musculoskeletal movement (GO:0050881)3.66409803
61multicellular organismal movement (GO:0050879)3.66409803
62negative regulation of Rho protein signal transduction (GO:0035024)3.60675727
63organic cation transport (GO:0015695)3.57714158
64cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.53372700
65protein-DNA complex disassembly (GO:0032986)3.50474311
66nucleosome disassembly (GO:0006337)3.50474311
67cilium movement (GO:0003341)3.49081405
68ether metabolic process (GO:0018904)3.46329889
69response to acidic pH (GO:0010447)3.44407001
70peptidyl-threonine dephosphorylation (GO:0035970)3.40311837
71polyamine biosynthetic process (GO:0006596)3.38004436
72regulation of microtubule-based movement (GO:0060632)3.32223026
73glomerular visceral epithelial cell development (GO:0072015)3.30413884
74negative regulation of gene expression, epigenetic (GO:0045814)3.30270088
75cerebral cortex neuron differentiation (GO:0021895)3.29811861
76histone H3-K9 demethylation (GO:0033169)3.22439099
77cellular response to pH (GO:0071467)3.22427880
78regulation of interleukin-13 production (GO:0032656)3.19386424
79glomerular epithelial cell development (GO:0072310)3.18770611
80protein depolymerization (GO:0051261)3.14427205
81regulation of T-helper 2 cell differentiation (GO:0045628)3.14151180
82membrane protein intracellular domain proteolysis (GO:0031293)3.11025030
83microtubule nucleation (GO:0007020)3.10604556
84mesenchymal cell differentiation involved in kidney development (GO:0072161)3.09062078
85mesenchymal cell differentiation involved in renal system development (GO:2001012)3.09062078
86homeostasis of number of cells within a tissue (GO:0048873)3.06142872
87cell recognition (GO:0008037)3.01753221
88multicellular organismal development (GO:0007275)3.00808964
89cell differentiation involved in metanephros development (GO:0072202)3.00140982
90cranial nerve morphogenesis (GO:0021602)2.96938645
91DNA conformation change (GO:0071103)2.92854884
92regulation of phosphoprotein phosphatase activity (GO:0043666)2.86265294
93NAD biosynthetic process (GO:0009435)2.82670362
94receptor recycling (GO:0001881)2.79665079
95Golgi to endosome transport (GO:0006895)2.76769149
96negative regulation of histone methylation (GO:0031061)2.76471765
97regulation of ARF GTPase activity (GO:0032312)2.75994939
98acrosome reaction (GO:0007340)12.3376298
99sperm motility (GO:0030317)11.8192303
100fusion of sperm to egg plasma membrane (GO:0007342)11.3853749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.61675069
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.68544446
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.54555311
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43735664
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.43735664
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18743763
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.17880184
8CBP_20019798_ChIP-Seq_JUKART_Human2.17880184
9VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.09872275
10ELF1_20517297_ChIP-Seq_JURKAT_Human2.08143311
11EZH2_22144423_ChIP-Seq_EOC_Human2.02276644
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98829307
13ERA_21632823_ChIP-Seq_H3396_Human1.98051532
14DROSHA_22980978_ChIP-Seq_HELA_Human1.93211903
15RAC3_21632823_ChIP-Seq_H3396_Human1.89036999
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84384490
17EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.82707141
18RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.80831200
19NANOG_20526341_ChIP-Seq_ESCs_Human1.80536533
20FUS_26573619_Chip-Seq_HEK293_Human1.79991347
21CTCF_27219007_Chip-Seq_Bcells_Human1.79614178
22EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.79576307
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.78275921
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68457330
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67713717
26BCL6_27268052_Chip-Seq_Bcells_Human1.67102049
27SMC4_20622854_ChIP-Seq_HELA_Human1.64119017
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60746398
29E2F1_20622854_ChIP-Seq_HELA_Human1.60471942
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.59103283
31ER_23166858_ChIP-Seq_MCF-7_Human1.56737104
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.56723110
33MYC_19829295_ChIP-Seq_ESCs_Human1.56036299
34ARNT_22903824_ChIP-Seq_MCF-7_Human1.55725693
35TAF2_19829295_ChIP-Seq_ESCs_Human1.54614331
36BCOR_27268052_Chip-Seq_Bcells_Human1.54536641
37P68_20966046_ChIP-Seq_HELA_Human1.53706903
38PHF8_20622854_ChIP-Seq_HELA_Human1.51611154
39CTCF_20526341_ChIP-Seq_ESCs_Human1.50297011
40TP63_22573176_ChIP-Seq_HFKS_Human1.49616655
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.48284541
42OCT4_20526341_ChIP-Seq_ESCs_Human1.47693595
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47373112
44PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44657321
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42202280
46LXR_22292898_ChIP-Seq_THP-1_Human1.42145344
47AR_25329375_ChIP-Seq_VCAP_Human1.42144706
48TP53_18474530_ChIP-ChIP_U2OS_Human1.40593985
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40086711
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39024019
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37510503
52P300_27268052_Chip-Seq_Bcells_Human1.36558625
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.35531671
54CBX2_22325352_ChIP-Seq_293T-Rex_Human1.34474761
55SMAD3_21741376_ChIP-Seq_ESCs_Human1.31882207
56RBPJ_21746931_ChIP-Seq_IB4_Human1.31752942
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31043303
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31038961
59ERG_20517297_ChIP-Seq_VCAP_Human1.31029615
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30544896
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30247223
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.26559654
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.26270963
64ETV1_20927104_ChIP-Seq_GIST48_Human1.26243120
65P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.24753131
66TAF15_26573619_Chip-Seq_HEK293_Human1.24339720
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23607982
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23228889
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22875864
70CEBPB_22108803_ChIP-Seq_LS180_Human1.20628461
71SOX2_22085726_ChIP-Seq_NPCs_Mouse1.20455695
72NFYB_21822215_ChIP-Seq_K562_Human1.18318481
73P300_19829295_ChIP-Seq_ESCs_Human1.18303772
74TBL1_22424771_ChIP-Seq_293T_Human1.17636254
75P53_21459846_ChIP-Seq_SAOS-2_Human1.15677952
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14534211
77SMAD4_21741376_ChIP-Seq_HESCs_Human1.14484014
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11920979
79RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11659043
80RUNX_20019798_ChIP-Seq_JUKART_Human1.11617179
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11145170
82SMRT_27268052_Chip-Seq_Bcells_Human1.10661625
83AR_21572438_ChIP-Seq_LNCaP_Human1.09809533
84SA1_27219007_Chip-Seq_Bcells_Human1.09732125
85PHF8_20622853_ChIP-Seq_HELA_Human1.09502894
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08919810
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.08282803
88GATA6_21074721_ChIP-Seq_CACO-2_Human1.05914707
89RUNX2_22187159_ChIP-Seq_PCA_Human1.04528934
90OCT1_27270436_Chip-Seq_PROSTATE_Human1.01231741
91ZNF274_21170338_ChIP-Seq_K562_Hela1.01102248
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.01037220
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.00963208
94NFYA_21822215_ChIP-Seq_K562_Human1.00817135
95NANOG_19829295_ChIP-Seq_ESCs_Human1.00283972
96SOX2_19829295_ChIP-Seq_ESCs_Human1.00283972
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00201414
98PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98102653
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98101152
100SMAD4_21799915_ChIP-Seq_A2780_Human0.98009217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.06713400
2MP0003878_abnormal_ear_physiology5.06713400
3MP0005670_abnormal_white_adipose4.66606367
4MP0003698_abnormal_male_reproductive4.48932755
5MP0001348_abnormal_lacrimal_gland3.88394382
6MP0001929_abnormal_gametogenesis3.87308135
7MP0000678_abnormal_parathyroid_gland2.63064016
8MP0002161_abnormal_fertility/fecundity2.49426432
9MP0003011_delayed_dark_adaptation2.12876305
10MP0003718_maternal_effect2.12667481
11MP0002132_abnormal_respiratory_system2.05625658
12MP0005410_abnormal_fertilization12.5908027
13MP0003646_muscle_fatigue1.85024726
14MP0005379_endocrine/exocrine_gland_phen1.83902570
15MP0002210_abnormal_sex_determination1.68419731
16MP0002234_abnormal_pharynx_morphology1.63936283
17MP0002249_abnormal_larynx_morphology1.60189108
18MP0005423_abnormal_somatic_nervous1.53853076
19MP0002282_abnormal_trachea_morphology1.51208547
20MP0009053_abnormal_anal_canal1.49705188
21MP0004510_myositis1.47091264
22MP0001486_abnormal_startle_reflex1.46541369
23MP0001485_abnormal_pinna_reflex1.46410053
24MP0002822_catalepsy1.42551395
25MP0001145_abnormal_male_reproductive1.37364351
26MP0000653_abnormal_sex_gland1.30547186
27MP0000534_abnormal_ureter_morphology1.24985488
28MP0002735_abnormal_chemical_nociception1.23791367
29MP0004859_abnormal_synaptic_plasticity1.22936628
30MP0005310_abnormal_salivary_gland1.22645802
31MP0005451_abnormal_body_composition1.20511561
32MP0001765_abnormal_ion_homeostasis1.17645469
33MP0001968_abnormal_touch/_nociception1.16152465
34MP0004742_abnormal_vestibular_system1.15766233
35MP0003879_abnormal_hair_cell1.11854435
36MP0005248_abnormal_Harderian_gland1.10063229
37MP0002127_abnormal_cardiovascular_syste1.08532563
38MP0002138_abnormal_hepatobiliary_system1.07800276
39MP0001963_abnormal_hearing_physiology1.05302815
40MP0005395_other_phenotype1.01343263
41MP0000026_abnormal_inner_ear0.96017639
42MP0002229_neurodegeneration0.82355455
43MP0000681_abnormal_thyroid_gland0.82182668
44MP0005666_abnormal_adipose_tissue0.82175445
45MP0000955_abnormal_spinal_cord0.82123046
46MP0005083_abnormal_biliary_tract0.81582152
47MP0009115_abnormal_fat_cell0.78338017
48MP0000049_abnormal_middle_ear0.77338911
49MP0002733_abnormal_thermal_nociception0.76782954
50MP0008569_lethality_at_weaning0.74569496
51MP0004085_abnormal_heartbeat0.74232956
52MP0002067_abnormal_sensory_capabilities0.73163025
53MP0005551_abnormal_eye_electrophysiolog0.72695809
54MP0005375_adipose_tissue_phenotype0.69049299
55MP0001879_abnormal_lymphatic_vessel0.68296283
56MP0008877_abnormal_DNA_methylation0.66315949
57MP0001905_abnormal_dopamine_level0.66090416
58MP0005367_renal/urinary_system_phenotyp0.64985658
59MP0000516_abnormal_urinary_system0.64985658
60MP0002557_abnormal_social/conspecific_i0.64535747
61MP0005623_abnormal_meninges_morphology0.62180253
62MP0005253_abnormal_eye_physiology0.60946013
63MP0005167_abnormal_blood-brain_barrier0.60916747
64MP0005636_abnormal_mineral_homeostasis0.58107664
65MP0002572_abnormal_emotion/affect_behav0.57659957
66MP0000003_abnormal_adipose_tissue0.55982743
67MP0009697_abnormal_copulation0.53599221
68MP0004484_altered_response_of0.52281126
69MP0008995_early_reproductive_senescence0.51965840
70MP0004233_abnormal_muscle_weight0.51279001
71MP0001970_abnormal_pain_threshold0.51210798
72MP0005535_abnormal_body_temperature0.50999389
73MP0001666_abnormal_nutrient_absorption0.50464694
74MP0001984_abnormal_olfaction0.48231670
75MP0001440_abnormal_grooming_behavior0.48066579
76MP0009745_abnormal_behavioral_response0.45078158
77MP0002734_abnormal_mechanical_nocicepti0.44544719
78MP0004036_abnormal_muscle_relaxation0.44207340
79MP0003119_abnormal_digestive_system0.43183206
80MP0002272_abnormal_nervous_system0.42993548
81MP0008961_abnormal_basal_metabolism0.42102279
82MP0001501_abnormal_sleep_pattern0.40946501
83MP0003077_abnormal_cell_cycle0.40443575
84MP0000470_abnormal_stomach_morphology0.40170175
85MP0003137_abnormal_impulse_conducting0.39788498
86MP0000249_abnormal_blood_vessel0.39450785
87MP0003091_abnormal_cell_migration0.37310845
88MP0002653_abnormal_ependyma_morphology0.36901751
89MP0003699_abnormal_female_reproductive0.36755137
90MP0000230_abnormal_systemic_arterial0.35667747
91MP0003936_abnormal_reproductive_system0.34832887
92MP0003880_abnormal_central_pattern0.34759160
93MP0005084_abnormal_gallbladder_morpholo0.34060342
94MP0000467_abnormal_esophagus_morphology0.34040309
95MP0003635_abnormal_synaptic_transmissio0.33961385
96MP0002928_abnormal_bile_duct0.33722315
97MP0003631_nervous_system_phenotype0.33569196
98MP0005391_vision/eye_phenotype0.32484469
99MP0004084_abnormal_cardiac_muscle0.31593088
100MP0006292_abnormal_olfactory_placode0.30688284

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.60186256
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.05748737
3Absent/shortened dynein arms (HP:0200106)6.05748737
4Asymmetric septal hypertrophy (HP:0001670)5.51335560
5Bony spicule pigmentary retinopathy (HP:0007737)5.25758243
6Attenuation of retinal blood vessels (HP:0007843)5.19522335
7Resting tremor (HP:0002322)4.72050988
8Tubulointerstitial nephritis (HP:0001970)4.71621051
9Abnormal ciliary motility (HP:0012262)4.68188091
10Abnormal respiratory motile cilium physiology (HP:0012261)4.57275116
11Bell-shaped thorax (HP:0001591)4.55433142
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.39487990
13Abnormal respiratory motile cilium morphology (HP:0005938)4.38770601
14Abnormal respiratory epithelium morphology (HP:0012253)4.38770601
15Male infertility (HP:0003251)4.26515719
16Infertility (HP:0000789)4.26209728
17Chronic hepatic failure (HP:0100626)4.24412837
18Hyperkalemia (HP:0002153)4.21776513
19Nasal polyposis (HP:0100582)4.19582005
20Hypoplastic ischia (HP:0003175)4.12914227
21Abnormal rod and cone electroretinograms (HP:0008323)4.10911286
22Abnormality of macular pigmentation (HP:0008002)3.97481909
23Potter facies (HP:0002009)3.97076707
24Facial shape deformation (HP:0011334)3.97076707
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.87742444
26Enlarged epiphyses (HP:0010580)3.83742404
27Abnormality of the ischium (HP:0003174)3.70489325
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.56201910
29Cone-rod dystrophy (HP:0000548)3.54073026
30Abnormality of the nasal mucosa (HP:0000433)3.41243004
31Abnormal spermatogenesis (HP:0008669)3.37059762
32Azoospermia (HP:0000027)3.34160314
33Impulsivity (HP:0100710)3.24013863
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.23950474
35Postural instability (HP:0002172)3.08742352
36Hypoplasia of the thymus (HP:0000778)3.07999196
37Unilateral renal agenesis (HP:0000122)2.95694800
38Progressive sensorineural hearing impairment (HP:0000408)2.89094735
39Hypoalphalipoproteinemia (HP:0003233)2.78744407
40Abnormal urine output (HP:0012590)2.77341633
41Rhinitis (HP:0012384)2.67006344
42Congenital malformation of the right heart (HP:0011723)2.66473940
43Double outlet right ventricle (HP:0001719)2.66473940
44Abnormality of the aortic arch (HP:0012303)2.63598826
45Generalized aminoaciduria (HP:0002909)2.61768776
46Stage 5 chronic kidney disease (HP:0003774)2.61739470
47Renal dysplasia (HP:0000110)2.61485665
48Nephronophthisis (HP:0000090)2.56945408
49Progressive cerebellar ataxia (HP:0002073)2.52975704
50Abnormality of dental color (HP:0011073)2.52079608
51Amelogenesis imperfecta (HP:0000705)2.49458532
52Abnormality of the costochondral junction (HP:0000919)2.49059448
53Truncal obesity (HP:0001956)2.49003618
54Abnormality of potassium homeostasis (HP:0011042)2.47087522
55Portal hypertension (HP:0001409)2.40495755
56Epiphyseal dysplasia (HP:0002656)2.39319979
57Abnormality of renal excretion (HP:0011036)2.37255414
58Renovascular hypertension (HP:0100817)2.30972150
59Flattened epiphyses (HP:0003071)2.30660489
60Polydipsia (HP:0001959)2.30351736
61Abnormal drinking behavior (HP:0030082)2.30351736
62Insulin-resistant diabetes mellitus (HP:0000831)2.29959100
63Tubulointerstitial abnormality (HP:0001969)2.28466035
64Ventricular tachycardia (HP:0004756)2.22734666
65Menstrual irregularities (HP:0000858)2.21345948
66Abnormality of the hepatic vasculature (HP:0006707)2.19977071
67Absent epiphyses (HP:0010577)2.19118330
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.19118330
69Abnormality of the renal medulla (HP:0100957)2.18356217
70Polyuria (HP:0000103)2.17713681
71Abnormality of the parathyroid morphology (HP:0011766)2.10055080
72Abnormality of the epiphysis of the femoral head (HP:0010574)2.06281699
73Abnormality of the pubic bones (HP:0003172)2.03758189
74Widely patent fontanelles and sutures (HP:0004492)2.03510641
75Osteomalacia (HP:0002749)1.99837322
76Bronchiectasis (HP:0002110)1.99169634
77Hypophosphatemic rickets (HP:0004912)1.98180786
78Hyponatremia (HP:0002902)1.96340631
79Abnormality of femoral epiphyses (HP:0006499)1.94642457
80Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.94642457
81Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93948635
82Chronic bronchitis (HP:0004469)1.88337834
83Focal segmental glomerulosclerosis (HP:0000097)1.87438010
84Spastic paraparesis (HP:0002313)1.85019905
85Tetany (HP:0001281)1.84420236
86Sensory axonal neuropathy (HP:0003390)1.83900792
87Abnormality of the femoral head (HP:0003368)1.83606001
88Progressive hearing impairment (HP:0001730)1.83130526
89Decreased central vision (HP:0007663)1.83093805
90Neoplasm of the heart (HP:0100544)1.82516533
91Recurrent corneal erosions (HP:0000495)1.82471083
92Flat capital femoral epiphysis (HP:0003370)1.82081181
93Recurrent pneumonia (HP:0006532)1.81353902
94Bradycardia (HP:0001662)1.80680879
95Intellectual disability, moderate (HP:0002342)1.80512872
96Myokymia (HP:0002411)1.80244458
97Short ribs (HP:0000773)1.80034240
98Transposition of the great arteries (HP:0001669)1.78602023
99Abnormal connection of the cardiac segments (HP:0011545)1.78602023
100Abnormal ventriculo-arterial connection (HP:0011563)1.78602023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.50063169
2TESK16.05207347
3DDR25.26701052
4INSRR3.77423278
5MAP4K23.56955792
6STK383.29352421
7PLK23.17434086
8BRD43.01561264
9PNCK2.77419256
10STK38L2.29698069
11PRKD32.26972338
12CAMK1G2.24255064
13MAPK152.23100754
14MST1R1.97301454
15PIK3CG1.80427620
16WNK11.76675457
17PDPK11.60759075
18PDK11.47733218
19CDK121.41585690
20DYRK1B1.37069111
21CDK71.29237306
22PTK2B1.18277132
23NEK61.17031288
24MAP3K91.10578584
25KSR21.08734478
26AKT30.97425021
27LATS20.95082903
28CAMK1D0.84236386
29PRKG20.76368726
30UHMK10.75593093
31RPS6KA20.74287052
32BRAF0.73146718
33MAP3K110.70564937
34TYRO30.69316970
35SIK20.68898759
36PRKG10.68250004
37PRKAA20.66287672
38MAP3K20.60792472
39RPS6KA10.59888282
40ROCK10.56158328
41LATS10.53972375
42MAP2K20.53669857
43MAP3K80.52026477
44CAMK10.51265697
45CDK30.46391663
46GSK3B0.44084683
47SGK4940.43419132
48SGK2230.43419132
49MUSK0.42427035
50CDK20.42204333
51WNK40.41910106
52MTOR0.40650280
53MAPK10.40050137
54MARK10.39951471
55RPS6KC10.39050747
56RPS6KL10.39050747
57STK390.38356755
58CDK10.38211902
59RPS6KA60.35939942
60MET0.35434262
61CDK40.35276785
62MAP3K10.35023495
63NTRK30.34593887
64ARAF0.34193796
65BMPR1B0.33824046
66MAPK80.33394416
67TESK20.32609654
68CAMK40.32056508
69PRKCG0.30946931
70PRKCZ0.29280750
71TIE10.28321102
72PINK10.28063631
73CHEK10.27470223
74RIPK40.26463589
75SGK10.25014340
76MAP3K40.23972976
77PRKCB0.23556746
78MAPK140.22686403
79MARK20.22506822
80OXSR10.22499796
81MAPK100.21812588
82MAPK110.18950622
83BRSK10.18261344
84FER0.17454559
85AKT10.15849615
86PKN10.15731898
87JAK30.15520013
88BLK0.13786547
89DYRK30.11895262
90FRK0.11046868
91PRKACB0.10378833
92PRKCE0.09410950
93RIPK10.09220421
94PRKAA10.08922996
95PRKACA0.07960072
96SGK20.07109295
97MAPK90.07077658
98NEK20.06867618
99CAMK2A0.06724370
100IKBKB0.05892851

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.93814915
2Fatty acid biosynthesis_Homo sapiens_hsa000615.79303415
3Olfactory transduction_Homo sapiens_hsa047403.72776373
4Butanoate metabolism_Homo sapiens_hsa006502.63003235
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.05651666
6Taste transduction_Homo sapiens_hsa047421.85799494
7Type I diabetes mellitus_Homo sapiens_hsa049401.77442433
8Dorso-ventral axis formation_Homo sapiens_hsa043201.76442347
9Allograft rejection_Homo sapiens_hsa053301.76244409
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74777852
11Autoimmune thyroid disease_Homo sapiens_hsa053201.71847140
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63696326
13Graft-versus-host disease_Homo sapiens_hsa053321.62044429
14Type II diabetes mellitus_Homo sapiens_hsa049301.58022202
15Antigen processing and presentation_Homo sapiens_hsa046121.54204295
16Phenylalanine metabolism_Homo sapiens_hsa003601.53978049
17Fatty acid degradation_Homo sapiens_hsa000711.45051577
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37445250
19Viral myocarditis_Homo sapiens_hsa054161.34462472
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.31934067
21Fatty acid metabolism_Homo sapiens_hsa012121.30601232
22RNA transport_Homo sapiens_hsa030131.28887863
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24964725
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19280523
25Arginine and proline metabolism_Homo sapiens_hsa003301.18723118
26Protein digestion and absorption_Homo sapiens_hsa049741.16856625
27Endocytosis_Homo sapiens_hsa041441.16295953
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.13645073
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03976839
30Salivary secretion_Homo sapiens_hsa049701.03331353
31Phototransduction_Homo sapiens_hsa047440.99639762
32Inositol phosphate metabolism_Homo sapiens_hsa005620.98525852
33Arginine biosynthesis_Homo sapiens_hsa002200.96424310
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96216292
35Morphine addiction_Homo sapiens_hsa050320.94344276
36Calcium signaling pathway_Homo sapiens_hsa040200.91908340
37Synaptic vesicle cycle_Homo sapiens_hsa047210.90698523
38cAMP signaling pathway_Homo sapiens_hsa040240.85777059
39Nicotine addiction_Homo sapiens_hsa050330.84558867
40Hedgehog signaling pathway_Homo sapiens_hsa043400.83526729
41PPAR signaling pathway_Homo sapiens_hsa033200.82588684
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80925397
43ABC transporters_Homo sapiens_hsa020100.80312169
44Renin-angiotensin system_Homo sapiens_hsa046140.79356811
45Oocyte meiosis_Homo sapiens_hsa041140.79168229
46Cardiac muscle contraction_Homo sapiens_hsa042600.78753943
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77312433
48Circadian entrainment_Homo sapiens_hsa047130.77238674
49Influenza A_Homo sapiens_hsa051640.76068642
50Estrogen signaling pathway_Homo sapiens_hsa049150.75149019
51Fat digestion and absorption_Homo sapiens_hsa049750.73261248
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73069008
53Tyrosine metabolism_Homo sapiens_hsa003500.69773397
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66958919
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66483548
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65603700
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64524869
58Selenocompound metabolism_Homo sapiens_hsa004500.62912298
59Glycerolipid metabolism_Homo sapiens_hsa005610.62610497
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62605711
61Glutamatergic synapse_Homo sapiens_hsa047240.58833262
62Renin secretion_Homo sapiens_hsa049240.57492640
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.55649336
64Gastric acid secretion_Homo sapiens_hsa049710.55616363
65Retinol metabolism_Homo sapiens_hsa008300.55455913
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.55150414
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.54704979
68VEGF signaling pathway_Homo sapiens_hsa043700.52108427
69Bile secretion_Homo sapiens_hsa049760.51427472
70Insulin secretion_Homo sapiens_hsa049110.50239423
71MAPK signaling pathway_Homo sapiens_hsa040100.49747293
72ECM-receptor interaction_Homo sapiens_hsa045120.49667872
73Tight junction_Homo sapiens_hsa045300.47210540
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46022367
75Serotonergic synapse_Homo sapiens_hsa047260.44905848
76Cholinergic synapse_Homo sapiens_hsa047250.43441734
77GABAergic synapse_Homo sapiens_hsa047270.41916542
78Acute myeloid leukemia_Homo sapiens_hsa052210.40651476
79Purine metabolism_Homo sapiens_hsa002300.38710958
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34788542
81Pancreatic secretion_Homo sapiens_hsa049720.34091631
82Oxytocin signaling pathway_Homo sapiens_hsa049210.32621079
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31666939
84Nitrogen metabolism_Homo sapiens_hsa009100.27443665
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.27285644
86Viral carcinogenesis_Homo sapiens_hsa052030.27065191
87mRNA surveillance pathway_Homo sapiens_hsa030150.26148089
88Basal transcription factors_Homo sapiens_hsa030220.26053728
89Long-term potentiation_Homo sapiens_hsa047200.25330453
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24357504
91Prolactin signaling pathway_Homo sapiens_hsa049170.24345267
92Adherens junction_Homo sapiens_hsa045200.18375826
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17497193
94Herpes simplex infection_Homo sapiens_hsa051680.16109125
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15330005
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15034652
97Biosynthesis of amino acids_Homo sapiens_hsa012300.13764084
98Toxoplasmosis_Homo sapiens_hsa051450.13763672
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.12813100
100Amphetamine addiction_Homo sapiens_hsa050310.11959889

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