FAM19A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1photoreceptor cell development (GO:0042461)9.78195222
2protein-chromophore linkage (GO:0018298)9.63655202
3negative regulation of retinoic acid receptor signaling pathway (GO:0048387)9.51894996
4eye photoreceptor cell development (GO:0042462)9.50854764
5regulation of gonadotropin secretion (GO:0032276)9.27871457
6retinal rod cell development (GO:0046548)9.21607721
7photoreceptor cell maintenance (GO:0045494)8.79480786
8phototransduction (GO:0007602)8.17865693
9phototransduction, visible light (GO:0007603)8.13928401
10detection of visible light (GO:0009584)8.12693202
11regulation of retinoic acid receptor signaling pathway (GO:0048385)8.03528865
12detection of light stimulus (GO:0009583)7.99749503
13chondrocyte proliferation (GO:0035988)7.50962729
14visual perception (GO:0007601)7.15193090
15sensory perception of light stimulus (GO:0050953)7.07819504
16positive regulation of guanylate cyclase activity (GO:0031284)6.90538283
17GMP metabolic process (GO:0046037)6.49687064
18regulation of guanylate cyclase activity (GO:0031282)6.19271056
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.97842573
20detection of external stimulus (GO:0009581)5.81447380
21detection of abiotic stimulus (GO:0009582)5.71355028
22cellular response to light stimulus (GO:0071482)5.63265576
23eye photoreceptor cell differentiation (GO:0001754)5.29110564
24photoreceptor cell differentiation (GO:0046530)5.29110564
25fusion of sperm to egg plasma membrane (GO:0007342)5.22276693
26ventricular cardiac muscle cell development (GO:0055015)5.05732432
27negative regulation of T cell differentiation in thymus (GO:0033085)5.05256296
28rRNA modification (GO:0000154)5.00920324
29retina development in camera-type eye (GO:0060041)4.96011380
30positive regulation of astrocyte differentiation (GO:0048711)4.89276393
31rRNA methylation (GO:0031167)4.88052150
32regulation of transforming growth factor beta2 production (GO:0032909)4.68150145
33cellular potassium ion homeostasis (GO:0030007)4.44744796
34positive regulation of protein homooligomerization (GO:0032464)4.43148958
35response to pheromone (GO:0019236)4.40809876
36regulation of cGMP metabolic process (GO:0030823)4.35119151
37epithelial cell-cell adhesion (GO:0090136)4.30672211
38detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.26848677
39regulation of voltage-gated calcium channel activity (GO:1901385)4.22548154
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.12648578
41acrosome reaction (GO:0007340)4.11899426
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.11274297
43regulation of G0 to G1 transition (GO:0070316)4.07642700
44positive regulation of cGMP biosynthetic process (GO:0030828)4.06339163
45regulation of cardioblast differentiation (GO:0051890)4.05317002
46polyamine biosynthetic process (GO:0006596)3.94189451
47peptidyl-proline hydroxylation (GO:0019511)3.91602336
48pyrimidine nucleoside salvage (GO:0043097)3.90163098
49pyrimidine-containing compound salvage (GO:0008655)3.90163098
50regulation of cGMP biosynthetic process (GO:0030826)3.78575809
51vitamin A metabolic process (GO:0006776)3.77508392
52ribosome assembly (GO:0042255)3.75689240
53regulation of short-term neuronal synaptic plasticity (GO:0048172)3.72902543
54response to acidic pH (GO:0010447)3.71941988
55proteasome assembly (GO:0043248)3.70017045
56nonmotile primary cilium assembly (GO:0035058)3.67196143
57plasma membrane fusion (GO:0045026)3.67052286
58potassium ion homeostasis (GO:0055075)3.60311563
59regulation of clathrin-mediated endocytosis (GO:2000369)3.57265158
60positive regulation of cGMP metabolic process (GO:0030825)3.52602738
61cellular response to radiation (GO:0071478)3.47207498
62membrane hyperpolarization (GO:0060081)3.46256355
63transcription from mitochondrial promoter (GO:0006390)3.44832129
64regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.43879588
65sensory perception (GO:0007600)3.43162897
66protein hydroxylation (GO:0018126)3.42826796
67sodium ion export (GO:0071436)3.41941435
68autophagic vacuole assembly (GO:0000045)3.41575139
69galactose metabolic process (GO:0006012)3.40882496
70estrogen biosynthetic process (GO:0006703)3.29288291
71cellular response to leptin stimulus (GO:0044320)3.27262445
72positive regulation of sodium ion transmembrane transport (GO:1902307)3.23122447
73peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.22712901
74type B pancreatic cell proliferation (GO:0044342)3.21672606
75binding of sperm to zona pellucida (GO:0007339)3.20744677
76regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.20019672
77oocyte development (GO:0048599)3.19472456
78tRNA methylation (GO:0030488)3.17868831
79negative regulation of homotypic cell-cell adhesion (GO:0034111)3.16856747
80protein localization to synapse (GO:0035418)3.15998670
81male meiosis I (GO:0007141)3.14545581
82negative regulation of transcription by competitive promoter binding (GO:0010944)3.13706610
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.10129908
84response to light stimulus (GO:0009416)3.09974687
85synaptic vesicle maturation (GO:0016188)3.09031382
86lipid translocation (GO:0034204)3.07964168
87phospholipid translocation (GO:0045332)3.07964168
88adaptation of signaling pathway (GO:0023058)3.07500190
89receptor guanylyl cyclase signaling pathway (GO:0007168)3.06466338
90mitochondrial fusion (GO:0008053)3.06288761
91multicellular organism reproduction (GO:0032504)3.06135305
92righting reflex (GO:0060013)3.05684978
93retina layer formation (GO:0010842)3.04118037
94chaperone-mediated protein transport (GO:0072321)3.03079424
95potassium ion export (GO:0071435)3.01542965
96positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.01169519
97negative regulation of cytosolic calcium ion concentration (GO:0051481)2.98244043
98regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.98088183
99hyaluronan catabolic process (GO:0030214)2.97323096
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93964114
101regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.93866462
102potassium ion import (GO:0010107)2.93220304
103cellular response to arsenic-containing substance (GO:0071243)2.92874821
104neuron development (GO:0048666)2.91216920
105cellular response to gonadotropin stimulus (GO:0071371)2.91116296
106response to histamine (GO:0034776)2.91111191
107sex determination (GO:0007530)2.90979255
108regulation of spindle organization (GO:0090224)2.90027971
109somite development (GO:0061053)2.89454154
110protein heterotetramerization (GO:0051290)2.89341632
111negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.89108496
112synaptic vesicle docking involved in exocytosis (GO:0016081)2.88327889
113negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.87699096
114negative regulation of calcium ion transmembrane transport (GO:1903170)2.87699096
115detection of chemical stimulus involved in sensory perception (GO:0050907)2.87483001
116basement membrane organization (GO:0071711)2.85368951
117negative regulation of macrophage differentiation (GO:0045650)2.83974933
118embryonic eye morphogenesis (GO:0048048)2.83011028
119regulation of cell communication by electrical coupling (GO:0010649)2.81631988
120response to leptin (GO:0044321)2.80975899
121glial cell migration (GO:0008347)2.80953380
122diterpenoid biosynthetic process (GO:0016102)2.80210548
123female gonad development (GO:0008585)2.79641844
124skin morphogenesis (GO:0043589)2.79584738
125sperm motility (GO:0030317)2.77572038
126regulation of mitotic spindle organization (GO:0060236)2.76938933
127blastocyst development (GO:0001824)2.76763359
128urogenital system development (GO:0001655)2.76263280
129behavioral response to ethanol (GO:0048149)2.75924320
130negative regulation of cation channel activity (GO:2001258)2.75887769
131CDP-diacylglycerol biosynthetic process (GO:0016024)2.75241847
132desmosome organization (GO:0002934)2.73805803
133sperm-egg recognition (GO:0035036)2.73540242
134regulation of skeletal muscle contraction (GO:0014819)2.72813787
135positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.72055283
136embryonic digestive tract morphogenesis (GO:0048557)2.71844386
137response to gonadotropin (GO:0034698)2.70659611
138positive regulation of T cell differentiation in thymus (GO:0033089)2.70021185
139substrate-dependent cell migration (GO:0006929)2.69350554
140mitochondrion transport along microtubule (GO:0047497)2.68958565
141establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.68958565
142endothelial cell chemotaxis (GO:0035767)2.68518377
143male gonad development (GO:0008584)2.67536837
144reproduction (GO:0000003)2.67501648
145nucleoside salvage (GO:0043174)2.66875657
146positive regulation of neurotransmitter transport (GO:0051590)2.66184361
147regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.65619728
148decidualization (GO:0046697)2.63564100
149cell morphogenesis involved in neuron differentiation (GO:0048667)2.63037760
150organic cation transport (GO:0015695)2.62993136
151regulation of membrane repolarization (GO:0060306)2.62938924
152smooth muscle tissue development (GO:0048745)2.60897883
153regulation of endocrine process (GO:0044060)2.59685921
154CDP-diacylglycerol metabolic process (GO:0046341)2.58919922
155regulation of synaptic vesicle exocytosis (GO:2000300)2.58772337
156regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.58285601
157negative regulation of cytokine biosynthetic process (GO:0042036)2.58104194
1584-hydroxyproline metabolic process (GO:0019471)2.57600959
159positive regulation of muscle hypertrophy (GO:0014742)2.56886222
160positive regulation of cardiac muscle hypertrophy (GO:0010613)2.56886222
161short-term memory (GO:0007614)2.55892849
162innervation (GO:0060384)2.55558445
163membrane repolarization (GO:0086009)2.53762852
164meiosis I (GO:0007127)2.51510550
165striatum development (GO:0021756)2.51488682
166heart trabecula formation (GO:0060347)2.51376275
167cell communication by electrical coupling (GO:0010644)2.50994897
168positive regulation of adherens junction organization (GO:1903393)2.50236370
169skeletal muscle tissue regeneration (GO:0043403)2.49817841
170trophoblast giant cell differentiation (GO:0060707)2.49635505
171regulation of calcium ion transmembrane transport (GO:1903169)2.49608519
172regulation of calcium ion transmembrane transporter activity (GO:1901019)2.49608519
173positive regulation of smoothened signaling pathway (GO:0045880)2.49557976
174positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.48957399
175single fertilization (GO:0007338)2.48782111
176positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.48755633
177very-low-density lipoprotein particle assembly (GO:0034379)2.46982073
178positive regulation of cell junction assembly (GO:1901890)2.46723726
179positive regulation of focal adhesion assembly (GO:0051894)2.46723726
180tissue regeneration (GO:0042246)2.46439984
181microtubule polymerization or depolymerization (GO:0031109)2.46433474
182regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.45584305
183regulation of mitochondrial translation (GO:0070129)2.45503521
184retinoid metabolic process (GO:0001523)2.44402676
185regulation of transforming growth factor beta1 production (GO:0032908)2.43959821
186membrane budding (GO:0006900)2.43779402
187positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.43439594
188positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.43057417
189protein retention in ER lumen (GO:0006621)2.42627021
190cardiac muscle hypertrophy in response to stress (GO:0014898)2.41925732
191muscle hypertrophy in response to stress (GO:0003299)2.41925732
192cardiac muscle adaptation (GO:0014887)2.41925732
193detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.41256941
194morphogenesis of an epithelial fold (GO:0060571)2.40659323
195branching involved in salivary gland morphogenesis (GO:0060445)2.39814036
196regulation of rhodopsin mediated signaling pathway (GO:0022400)13.2037463
197rhodopsin mediated signaling pathway (GO:0016056)13.1280630
198retinal cone cell development (GO:0046549)13.0508598
199detection of light stimulus involved in sensory perception (GO:0050962)10.8222360
200detection of light stimulus involved in visual perception (GO:0050908)10.8222360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.40438278
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.19522642
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.02131864
4ZNF263_19887448_ChIP-Seq_K562_Human3.54312517
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.35775115
6GBX2_23144817_ChIP-Seq_PC3_Human2.72663779
7DROSHA_22980978_ChIP-Seq_HELA_Human2.68905979
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.61904510
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45840447
10CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.35540161
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.31491651
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25989488
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.25524529
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19359995
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10503431
16ATF3_27146783_Chip-Seq_COLON_Human2.02971220
17PPAR_26484153_Chip-Seq_NCI-H1993_Human1.96791705
18VDR_22108803_ChIP-Seq_LS180_Human1.92970279
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.92395379
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.90267903
21RACK7_27058665_Chip-Seq_MCF-7_Human1.89673527
22* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.89547680
23AR_21572438_ChIP-Seq_LNCaP_Human1.86361004
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83611899
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81629382
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.80112472
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75613350
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72027618
29* TET1_21451524_ChIP-Seq_MESCs_Mouse1.71594352
30P53_22127205_ChIP-Seq_FIBROBLAST_Human1.71079346
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.71053029
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67732863
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67732863
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67012102
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64286700
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63194120
37ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.63161855
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62479877
39* LXR_22292898_ChIP-Seq_THP-1_Human1.62213786
40* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60009748
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.57954597
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57539724
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57538119
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57025352
45* UBF1/2_26484160_Chip-Seq_HMECs_Human1.56363233
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55806868
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.55339793
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.54615796
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.54590014
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53540901
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52787339
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52239554
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51467846
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51273832
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.51147991
56CTCF_18555785_ChIP-Seq_MESCs_Mouse1.50200973
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48393619
58RUNX_20019798_ChIP-Seq_JUKART_Human1.48020186
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.47521801
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.47079866
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45998881
62SMAD3_21741376_ChIP-Seq_HESCs_Human1.45867891
63SMAD4_21799915_ChIP-Seq_A2780_Human1.45117049
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.44741370
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42804457
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42533955
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42078398
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41324787
69CSB_26484114_Chip-Seq_FIBROBLAST_Human1.41291704
70REST_21632747_ChIP-Seq_MESCs_Mouse1.40984534
71KDM2B_26808549_Chip-Seq_K562_Human1.38952370
72AR_19668381_ChIP-Seq_PC3_Human1.36004557
73* RBPJ_21746931_ChIP-Seq_IB4_Human1.34549913
74BCAT_22108803_ChIP-Seq_LS180_Human1.34513655
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34025130
76TP53_22127205_ChIP-Seq_IMR90_Human1.32878608
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.32097555
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29971901
79* TBL1_22424771_ChIP-Seq_293T_Human1.29903781
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29870704
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.28828424
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28657749
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27345092
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27325666
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26866087
86STAT3_23295773_ChIP-Seq_U87_Human1.26199292
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26100542
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.25434469
89TBX20_22080862_ChIP-Seq_HEART_Mouse1.25434469
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.24461190
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24344970
92* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23711845
93* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23702871
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.23596069
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.23527391
96EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23222999
97RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23222999
98* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.23055044
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.22884918
100KDM2B_26808549_Chip-Seq_DND41_Human1.22738304
101* CTCF_27219007_Chip-Seq_Bcells_Human1.21409172
102* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21295967
103JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20448503
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19030281
105CTCF_20526341_ChIP-Seq_ESCs_Human1.18951181
106SA1_27219007_Chip-Seq_ERYTHROID_Human1.18651530
107* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18217898
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17487682
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16713891
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15407730
111* PHF8_20622853_ChIP-Seq_HELA_Human1.14940476
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14842573
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.14411070
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.14133781
115SMC4_20622854_ChIP-Seq_HELA_Human1.13406178
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13312209
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13169153
118ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12489365
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12467115
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12441194
121TP63_22573176_ChIP-Seq_HFKS_Human1.12164563
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12059749
123TET1_21490601_ChIP-Seq_MESCs_Mouse1.12034900
124TCF4_23295773_ChIP-Seq_U87_Human1.11351562
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10056958
126SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09705087
127CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09643061
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09578976
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08841390
130FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08056788
131SMAD4_21741376_ChIP-Seq_HESCs_Human1.07838524
132ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07441850
133* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07154669
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06812237
135JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06719088
136RARA_24833708_ChIP-Seq_LIVER_Mouse1.06564370
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06502191
138JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05030199
139GABP_19822575_ChIP-Seq_HepG2_Human1.03197780
140* ETV1_20927104_ChIP-Seq_GIST48_Human1.01675000
141AHR_22903824_ChIP-Seq_MCF-7_Human1.01608503
142P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01566849
143* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01410503
144PRDM14_20953172_ChIP-Seq_ESCs_Human1.00724695
145P68_20966046_ChIP-Seq_HELA_Human1.00669995
146* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99583198
147* GATA6_21074721_ChIP-Seq_CACO-2_Human0.99166409
148* CTCF_21964334_Chip-Seq_Bcells_Human0.99117402
149NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99042504
150EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98950312
151EGR1_19032775_ChIP-ChIP_M12_Human0.98567961
152* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98444132
153ISL1_27105846_Chip-Seq_CPCs_Mouse0.98357960
154NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97475718
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97292075
156HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97247232
157SA1_22415368_ChIP-Seq_MEFs_Mouse0.97152960
158PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96908137
159AR_21909140_ChIP-Seq_LNCAP_Human0.96813055
160WDR5_24793694_ChIP-Seq_LNCAP_Human0.96739031
161ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96592607
162TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96249688
163CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96006459
164SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95956540
165SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95747243
166YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95274697
167SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94892567
168SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94885725
169TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94763574
170POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94449146
171SA1_27219007_Chip-Seq_Bcells_Human0.94420601
172LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94412629
173NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93730634
174NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93136086
175E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92730141
176GATA1_19941827_ChIP-Seq_MEL_Mouse0.92425712
177DCP1A_22483619_ChIP-Seq_HELA_Human0.92383419
178FLI1_21867929_ChIP-Seq_TH2_Mouse0.92052089
179IGF1R_20145208_ChIP-Seq_DFB_Human0.91964590
180CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91946032
181AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91522022
182CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91345385
183HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91205494
184CTCF_26484167_Chip-Seq_Bcells_Mouse0.91149112
185* HNFA_21074721_ChIP-Seq_CACO-2_Human0.91109402
186* SOX2_21211035_ChIP-Seq_LN229_Gbm0.90825168
187P300_19829295_ChIP-Seq_ESCs_Human0.90770059
188NCOR1_26117541_ChIP-Seq_K562_Human0.90571683
189ARNT_22903824_ChIP-Seq_MCF-7_Human0.90537944
190TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90444401
191POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90444401
192EZH2_27304074_Chip-Seq_ESCs_Mouse0.89660606
193EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89619897
194ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89249520
195* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89131506
196TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88885661
197TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88792639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation9.17060566
2MP0005551_abnormal_eye_electrophysiolog8.82984875
3MP0003283_abnormal_digestive_organ7.17743461
4MP0005253_abnormal_eye_physiology5.95423930
5MP0006072_abnormal_retinal_apoptosis5.85173884
6MP0003950_abnormal_plasma_membrane4.01039634
7MP0004858_abnormal_nervous_system3.62709250
8MP0002090_abnormal_vision3.45626534
9MP0005195_abnormal_posterior_eye3.42491217
10MP0008260_abnormal_autophagy3.40197720
11MP0008438_abnormal_cutaneous_collagen3.30485879
12MP0005410_abnormal_fertilization3.24814455
13MP0003195_calcinosis2.88177450
14MP0001324_abnormal_eye_pigmentation2.83782409
15MP0005391_vision/eye_phenotype2.70011278
16MP0005058_abnormal_lysosome_morphology2.69870762
17MP0004272_abnormal_basement_membrane2.66345269
18MP0005423_abnormal_somatic_nervous2.62987402
19MP0002229_neurodegeneration2.55714859
20MP0000462_abnormal_digestive_system2.03391125
21MP0000751_myopathy2.00775978
22MP0004233_abnormal_muscle_weight1.95956664
23MP0002752_abnormal_somatic_nervous1.81398552
24MP0010030_abnormal_orbit_morphology1.81355200
25MP0001986_abnormal_taste_sensitivity1.80153080
26MP0002638_abnormal_pupillary_reflex1.77231961
27MP0004036_abnormal_muscle_relaxation1.72116475
28MP0004215_abnormal_myocardial_fiber1.72033550
29MP0001881_abnormal_mammary_gland1.70816363
30MP0000749_muscle_degeneration1.67617916
31MP0003646_muscle_fatigue1.67502092
32MP0001661_extended_life_span1.66242597
33MP0002822_catalepsy1.62541699
34MP0004145_abnormal_muscle_electrophysio1.61073714
35MP0004084_abnormal_cardiac_muscle1.60219176
36MP0003718_maternal_effect1.58615758
37MP0009250_abnormal_appendicular_skeleto1.56403482
38MP0001984_abnormal_olfaction1.54620644
39MP0001905_abnormal_dopamine_level1.47900685
40MP0002896_abnormal_bone_mineralization1.45261317
41MP0001502_abnormal_circadian_rhythm1.39842340
42MP0002837_dystrophic_cardiac_calcinosis1.35923596
43MP0005395_other_phenotype1.35721465
44MP0002332_abnormal_exercise_endurance1.34820698
45MP0005508_abnormal_skeleton_morphology1.34315987
46MP0008875_abnormal_xenobiotic_pharmacok1.33123092
47MP0002882_abnormal_neuron_morphology1.30974540
48MP0003191_abnormal_cellular_cholesterol1.25696178
49MP0003091_abnormal_cell_migration1.25077895
50MP0004270_analgesia1.24997315
51MP0000678_abnormal_parathyroid_gland1.22830748
52MP0005620_abnormal_muscle_contractility1.20818193
53MP0002127_abnormal_cardiovascular_syste1.19335956
54MP0005164_abnormal_response_to1.17465853
55MP0002653_abnormal_ependyma_morphology1.17436007
56MP0003806_abnormal_nucleotide_metabolis1.17039901
57MP0002168_other_aberrant_phenotype1.16213433
58MP0005023_abnormal_wound_healing1.15575042
59MP0002933_joint_inflammation1.14270410
60MP0000358_abnormal_cell_content/1.14197227
61MP0001764_abnormal_homeostasis1.13533341
62MP0000762_abnormal_tongue_morphology1.11714437
63MP0001486_abnormal_startle_reflex1.11221868
64MP0001929_abnormal_gametogenesis1.10905697
65MP0005330_cardiomyopathy1.07532633
66MP0009697_abnormal_copulation1.06575518
67MP0004130_abnormal_muscle_cell1.04958713
68MP0003279_aneurysm1.03766292
69MP0003183_abnormal_peptide_metabolism1.03429287
70MP0004087_abnormal_muscle_fiber1.02904289
71MP0005623_abnormal_meninges_morphology1.02118858
72MP0001968_abnormal_touch/_nociception1.01559118
73MP0009379_abnormal_foot_pigmentation1.01170429
74MP0010368_abnormal_lymphatic_system1.00617251
75MP0000627_abnormal_mammary_gland0.99377808
76MP0003786_premature_aging0.96807337
77MP0002972_abnormal_cardiac_muscle0.95117310
78MP0003878_abnormal_ear_physiology0.94519959
79MP0005377_hearing/vestibular/ear_phenot0.94519959
80MP0003698_abnormal_male_reproductive0.94458209
81MP0000759_abnormal_skeletal_muscle0.92011679
82MP0000747_muscle_weakness0.91860727
83MP0002269_muscular_atrophy0.91546293
84MP0004957_abnormal_blastocyst_morpholog0.90578100
85MP0002210_abnormal_sex_determination0.90021897
86MP0002089_abnormal_postnatal_growth/wei0.86290839
87MP0003045_fibrosis0.85907668
88MP0004019_abnormal_vitamin_homeostasis0.85652625
89MP0002254_reproductive_system_inflammat0.85461019
90MP0002106_abnormal_muscle_physiology0.85150954
91MP0002272_abnormal_nervous_system0.83698882
92MP0000343_altered_response_to0.83169026
93MP0003077_abnormal_cell_cycle0.82853762
94MP0003936_abnormal_reproductive_system0.81542482
95MP0004085_abnormal_heartbeat0.81206886
96MP0002751_abnormal_autonomic_nervous0.80990444
97MP0004510_myositis0.79131872
98MP0000003_abnormal_adipose_tissue0.79108535
99MP0002161_abnormal_fertility/fecundity0.78636935
100MP0002734_abnormal_mechanical_nocicepti0.78305461
101MP0004185_abnormal_adipocyte_glucose0.77999786
102MP0005451_abnormal_body_composition0.77813413
103MP0005171_absent_coat_pigmentation0.77245914
104MP0010307_abnormal_tumor_latency0.76920646
105MP0003315_abnormal_perineum_morphology0.76377328
106MP0009384_cardiac_valve_regurgitation0.76305765
107MP0003828_pulmonary_edema0.75326549
108MP0008775_abnormal_heart_ventricle0.75147674
109MP0000750_abnormal_muscle_regeneration0.74953634
110MP0003137_abnormal_impulse_conducting0.74279540
111MP0001853_heart_inflammation0.74001239
112MP0005499_abnormal_olfactory_system0.73618789
113MP0005394_taste/olfaction_phenotype0.73618789
114MP0005408_hypopigmentation0.73394101
115MP0000465_gastrointestinal_hemorrhage0.72911559
116MP0002067_abnormal_sensory_capabilities0.72413901
117MP0009840_abnormal_foam_cell0.72143565
118MP0008995_early_reproductive_senescence0.71697791
119MP0009333_abnormal_splenocyte_physiolog0.71133410
120MP0006276_abnormal_autonomic_nervous0.70136195
121MP0005197_abnormal_uvea_morphology0.69801571
122MP0000767_abnormal_smooth_muscle0.67774939
123MP0009046_muscle_twitch0.67185535
124MP0002909_abnormal_adrenal_gland0.67019217
125MP0002735_abnormal_chemical_nociception0.66425428
126MP0003693_abnormal_embryo_hatching0.65677410
127MP0008569_lethality_at_weaning0.65667522
128MP0002060_abnormal_skin_morphology0.65347605
129MP0005369_muscle_phenotype0.65009967
130MP0005503_abnormal_tendon_morphology0.64839113
131MP0010630_abnormal_cardiac_muscle0.64279455
132MP0003880_abnormal_central_pattern0.63734864
133MP0001851_eye_inflammation0.63291167
134MP0001346_abnormal_lacrimal_gland0.62906026
135MP0005319_abnormal_enzyme/_coenzyme0.62551793
136MP0004883_abnormal_blood_vessel0.61919877
137MP0005193_abnormal_anterior_eye0.61914056
138MP0003635_abnormal_synaptic_transmissio0.61876144
139MP0006035_abnormal_mitochondrial_morpho0.60590575
140MP0005409_darkened_coat_color0.60407676
141MP0008932_abnormal_embryonic_tissue0.60370931
142MP0003634_abnormal_glial_cell0.59856074
143MP0005257_abnormal_intraocular_pressure0.59575719
144MP0000163_abnormal_cartilage_morphology0.59456732
145MP0008789_abnormal_olfactory_epithelium0.59011975
146MP0000516_abnormal_urinary_system0.58859040
147MP0005367_renal/urinary_system_phenotyp0.58859040
148MP0001145_abnormal_male_reproductive0.58740377
149MP0002064_seizures0.56319855
150MP0001544_abnormal_cardiovascular_syste0.55749866
151MP0005385_cardiovascular_system_phenoty0.55749866
152MP0004885_abnormal_endolymph0.55399218
153MP0005386_behavior/neurological_phenoty0.55220712
154MP0004924_abnormal_behavior0.55220712
155MP0004484_altered_response_of0.53403295
156MP0010386_abnormal_urinary_bladder0.53070362
157MP0005248_abnormal_Harderian_gland0.51896743
158MP0005076_abnormal_cell_differentiation0.51736979
159MP0008961_abnormal_basal_metabolism0.50710802
160MP0003879_abnormal_hair_cell0.49560627
161MP0005666_abnormal_adipose_tissue0.49346258
162MP0002736_abnormal_nociception_after0.47303230
163MP0001963_abnormal_hearing_physiology0.46961622
164MP0005670_abnormal_white_adipose0.45491212
165MP0002184_abnormal_innervation0.45156020
166MP0004859_abnormal_synaptic_plasticity0.43943466
167MP0006292_abnormal_olfactory_placode0.43380600
168MP0000733_abnormal_muscle_development0.42682091
169MP0002063_abnormal_learning/memory/cond0.41496566
170MP0001879_abnormal_lymphatic_vessel0.39858900
171MP0005187_abnormal_penis_morphology0.39113469
172MP0002108_abnormal_muscle_morphology0.38426791
173MP0004742_abnormal_vestibular_system0.35929813
174MP0002572_abnormal_emotion/affect_behav0.34558652
175MP0003300_gastrointestinal_ulcer0.33393840
176MP0001970_abnormal_pain_threshold0.32783706
177MP0002234_abnormal_pharynx_morphology0.31916446
178MP0003172_abnormal_lysosome_physiology0.30810908
179MP0004811_abnormal_neuron_physiology0.28829698
180MP0008004_abnormal_stomach_pH0.28822096

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.70602660
2Absent rod-and cone-mediated responses on ERG (HP:0007688)9.62085303
3Abnormal rod and cone electroretinograms (HP:0008323)8.97907239
4Central scotoma (HP:0000603)8.87068767
5Abnormality of macular pigmentation (HP:0008002)8.52521673
6Scotoma (HP:0000575)7.43475091
7Pigmentary retinal degeneration (HP:0001146)7.38377289
8Pendular nystagmus (HP:0012043)7.16551152
9Decreased central vision (HP:0007663)6.89752324
10Attenuation of retinal blood vessels (HP:0007843)6.44876861
11Chorioretinal atrophy (HP:0000533)6.43044196
12Abolished electroretinogram (ERG) (HP:0000550)6.13117073
13Severe visual impairment (HP:0001141)6.00113887
14Male infertility (HP:0003251)5.56821439
15Increased corneal curvature (HP:0100692)5.26967624
16Keratoconus (HP:0000563)5.26967624
17Photophobia (HP:0000613)5.05568726
18Macular degeneration (HP:0000608)5.00669162
19Type II diabetes mellitus (HP:0005978)4.71946341
20Abnormality of the phalanges of the hallux (HP:0010057)4.70012620
21Vitreoretinal degeneration (HP:0000655)4.69749155
22Posterior subcapsular cataract (HP:0007787)4.58506202
23Cone-rod dystrophy (HP:0000548)4.49879145
24Constricted visual fields (HP:0001133)4.16428883
25Choroideremia (HP:0001139)3.97674973
26Abnormality of glycolipid metabolism (HP:0010969)3.96291021
27Abnormality of liposaccharide metabolism (HP:0010968)3.96291021
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.96291021
29Short tibia (HP:0005736)3.83466490
30Flared iliac wings (HP:0002869)3.78395093
31Abnormality of the 1st metacarpal (HP:0010009)3.67351299
32Retinitis pigmentosa (HP:0000510)3.58587727
33Nuclear cataract (HP:0100018)3.54355870
34Hypoplasia of the uterus (HP:0000013)3.53426999
35Abnormality of the middle phalanges of the toes (HP:0010183)3.52578457
36Decreased electroretinogram (ERG) amplitude (HP:0000654)3.39669948
37Aplasia/hypoplasia of the uterus (HP:0008684)3.33200380
38Aplasia/Hypoplasia of the tibia (HP:0005772)3.30089377
39Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.26388346
40Abnormality of carpal bone ossification (HP:0006257)3.21872184
41Cupped ribs (HP:0000887)3.19591906
42Abnormality of the distal phalanx of the thumb (HP:0009617)3.16309846
43Coxa vara (HP:0002812)3.15795279
44Abnormality of the proximal phalanges of the hand (HP:0009834)3.12192453
45Trismus (HP:0000211)3.06509243
46Gonadotropin excess (HP:0000837)2.97636238
47Gonadal dysgenesis (HP:0000133)2.96591892
48Abnormality of the 2nd finger (HP:0004100)2.95879950
49Spastic paraparesis (HP:0002313)2.91110698
50Short phalanx of the thumb (HP:0009660)2.89766436
51Patent foramen ovale (HP:0001655)2.89116619
52Subcapsular cataract (HP:0000523)2.86939180
53Progressive sensorineural hearing impairment (HP:0000408)2.82219734
54J-shaped sella turcica (HP:0002680)2.80163994
55Congenital sensorineural hearing impairment (HP:0008527)2.76873226
56Abnormal ossification of hand bones (HP:0005921)2.68714581
57Premature ovarian failure (HP:0008209)2.65489900
58Malnutrition (HP:0004395)2.65374447
59Progressive visual loss (HP:0000529)2.64763327
60Genu varum (HP:0002970)2.62864201
61Abnormality of femoral epiphyses (HP:0006499)2.60230575
62Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.60230575
63Relative macrocephaly (HP:0004482)2.59057501
64Hand muscle atrophy (HP:0009130)2.53732162
65Abnormal hand bone ossification (HP:0010660)2.53390976
66Aplasia/hypoplasia of the humerus (HP:0006507)2.52699950
67Short femoral neck (HP:0100864)2.51703546
68Small epiphyses (HP:0010585)2.44638679
69Distal lower limb muscle weakness (HP:0009053)2.44277481
70Abnormality of the epiphysis of the femoral head (HP:0010574)2.43033565
71Lumbar hyperlordosis (HP:0002938)2.40994379
72Vertebral compression fractures (HP:0002953)2.40685626
73Mitral stenosis (HP:0001718)2.38959211
74Distal upper limb amyotrophy (HP:0007149)2.38111601
75Upper limb amyotrophy (HP:0009129)2.38111601
76Optic disc pallor (HP:0000543)2.37879442
77Truncus arteriosus (HP:0001660)2.37195331
78Ovoid vertebral bodies (HP:0003300)2.30123900
79Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.27134701
80Short hallux (HP:0010109)2.24898636
81Abnormality of the femoral head (HP:0003368)2.23165715
82Retinal atrophy (HP:0001105)2.22562437
83Selective tooth agenesis (HP:0001592)2.21850786
84Infertility (HP:0000789)2.21421997
85Carpal bone hypoplasia (HP:0001498)2.20985673
86Cerebral aneurysm (HP:0004944)2.18278997
87Prolonged QT interval (HP:0001657)2.15152971
88Short humerus (HP:0005792)2.13934708
89Exercise-induced myalgia (HP:0003738)2.09112422
90Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.08915273
91Wide nasal bridge (HP:0000431)2.06802513
92Abnormality of the aortic arch (HP:0012303)2.06567970
93Hypergonadotropic hypogonadism (HP:0000815)2.05829504
94Paraparesis (HP:0002385)2.05285685
95Rough bone trabeculation (HP:0100670)2.04232749
96Protrusio acetabuli (HP:0003179)2.03386109
97Cerebral hypomyelination (HP:0006808)2.01423843
98Congenital stationary night blindness (HP:0007642)13.7486926
99Dyschromatopsia (HP:0007641)10.2944584
100Premature rupture of membranes (HP:0001788)1.99669497
101Progressive hearing impairment (HP:0001730)1.99491739
102Hypokinesia (HP:0002375)1.97253869
103Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96780998
104Absent epiphyses (HP:0010577)1.96780998
105Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96465729
106Sex reversal (HP:0012245)1.95326693
107Abnormal sex determination (HP:0012244)1.95326693
108Exercise-induced muscle cramps (HP:0003710)1.95212372
109Aplasia/Hypoplasia of the hallux (HP:0008362)1.93868888
110Diaphragmatic weakness (HP:0009113)1.93379981
111Absent phalangeal crease (HP:0006109)1.92292757
112Spinal rigidity (HP:0003306)1.91957379
113Short nail (HP:0001799)1.90594532
114Ankle contracture (HP:0006466)1.90193904
115Abnormal auditory evoked potentials (HP:0006958)1.89271632
116Deformed sella turcica (HP:0002681)1.86935814
117Abnormal umbilical cord blood vessels (HP:0011403)1.86522049
118Single umbilical artery (HP:0001195)1.86522049
119Abnormality of the fetal cardiovascular system (HP:0010948)1.86522049
120Double outlet right ventricle (HP:0001719)1.86072133
121Congenital malformation of the right heart (HP:0011723)1.86072133
122Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85157182
123Pili torti (HP:0003777)1.83594937
124Stridor (HP:0010307)1.82656458
125Spinal cord compression (HP:0002176)1.81183369
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80197361
127Generalized amyotrophy (HP:0003700)1.78694101
128Horizontal nystagmus (HP:0000666)1.76489902
129Abnormality of the distal phalanges of the toes (HP:0010182)1.75188133
130Neoplasm of head and neck (HP:0012288)1.75068954
131Esophageal neoplasm (HP:0100751)1.75068954
132Severe Myopia (HP:0011003)1.75012562
133Syncope (HP:0001279)1.73990562
134Atrial fibrillation (HP:0005110)1.73618130
135Peripheral hypomyelination (HP:0007182)1.73318569
136Gait imbalance (HP:0002141)1.71012868
137Febrile seizures (HP:0002373)1.70580289
138Congenital primary aphakia (HP:0007707)1.69072688
139Hyporeflexia of lower limbs (HP:0002600)1.62754242
140Dysmetric saccades (HP:0000641)1.62343490
141Polar cataract (HP:0010696)1.59667738
142Epileptic encephalopathy (HP:0200134)1.58659197
143Primary atrial arrhythmia (HP:0001692)1.58321345
144Abnormal EKG (HP:0003115)1.58111666
145Abnormality of the calf musculature (HP:0001430)1.50218935
146Truncal ataxia (HP:0002078)1.47940866
147Supraventricular tachycardia (HP:0004755)1.47341571
148Sudden death (HP:0001699)1.46993035
149Ventricular fibrillation (HP:0001663)1.46402741
150Calf muscle hypertrophy (HP:0008981)1.44878650
151Supraventricular arrhythmia (HP:0005115)1.43461854
152Muscle hypertrophy of the lower extremities (HP:0008968)1.42874796
153Left ventricular hypertrophy (HP:0001712)1.42640608
154Nephrogenic diabetes insipidus (HP:0009806)1.42183776
155Dysdiadochokinesis (HP:0002075)1.41966645
156Medial flaring of the eyebrow (HP:0010747)1.39389626
157Difficulty running (HP:0009046)1.38035970
158Poor coordination (HP:0002370)1.31870366
159Myoglobinuria (HP:0002913)1.29228997
160Optic atrophy (HP:0000648)1.27858657
161Muscle fiber splitting (HP:0003555)1.26571532
162Abnormality of the fingertips (HP:0001211)1.23585867
163Progressive cerebellar ataxia (HP:0002073)1.22729144
164Genetic anticipation (HP:0003743)1.22308121
165Absence seizures (HP:0002121)1.20909460
166Vaginal atresia (HP:0000148)1.16266614
167Genital tract atresia (HP:0001827)1.16165029
168Interstitial pulmonary disease (HP:0006530)1.12567969
169Astigmatism (HP:0000483)1.11200342
170Pancreatic fibrosis (HP:0100732)1.09715619
171Abnormality of the fovea (HP:0000493)1.09512435
172Hypoplasia of the fovea (HP:0007750)1.08412691
173Aplasia/Hypoplasia of the fovea (HP:0008060)1.08412691
174Aplasia/Hypoplasia of the lens (HP:0008063)1.06286106
175EMG: myopathic abnormalities (HP:0003458)1.05437543
176True hermaphroditism (HP:0010459)1.02766835
177Macroorchidism (HP:0000053)1.02661830
178Cerebellar dysplasia (HP:0007033)1.02510776
179Visual hallucinations (HP:0002367)0.99560781
180Retinal detachment (HP:0000541)0.97500370
181Aplasia/Hypoplasia of the tongue (HP:0010295)0.97231675
182Ventricular tachycardia (HP:0004756)0.95842018
183Muscle stiffness (HP:0003552)0.95770852
184Hypermetropia (HP:0000540)0.93509739
185Urinary bladder sphincter dysfunction (HP:0002839)0.93415246
186Mask-like facies (HP:0000298)0.90237483
187Recurrent sinusitis (HP:0011108)0.90077037
188Frequent falls (HP:0002359)0.88093045
189Hemiplegia (HP:0002301)0.86864011
190Subaortic stenosis (HP:0001682)0.85952348
191Abnormality of the left ventricular outflow tract (HP:0011103)0.85952348
192Muscle fiber inclusion bodies (HP:0100299)0.85392104
193Partial agenesis of the corpus callosum (HP:0001338)0.85250718
194Hypoventilation (HP:0002791)0.85030044
195Dialeptic seizures (HP:0011146)0.84810665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK17.10405913
2NME26.06387393
3PBK5.13863453
4LATS23.69229545
5EPHA43.48815740
6TESK13.26062798
7MAP3K123.05571455
8EPHA22.79411753
9BUB12.74417132
10PINK12.69741131
11PAK42.63938880
12PHKG22.58824459
13PHKG12.58824459
14NEK12.12864476
15STK382.10198339
16DDR22.05692974
17PAK62.05172776
18CAMK1G2.02305325
19TTN1.94958558
20OBSCN1.90959397
21CDK121.88913560
22MST1R1.81784366
23EPHA31.81391011
24TAOK21.78872378
25ERBB41.76232053
26MAP3K71.57553159
27CAMK1D1.57229881
28LMTK21.49757619
29PTK21.46528198
30MET1.44654052
31MOS1.42716012
32PRPF4B1.39087690
33MAPK121.37864225
34PAK11.35984274
35BRD41.35853681
36NME11.35500005
37ABL21.34814861
38SIK21.33371933
39MAP3K101.30249124
40WNK11.27985070
41TXK1.26082319
42PRKCH1.26052809
43PKN21.25203325
44MAP3K31.23141347
45STK38L1.21363401
46BRSK11.20856767
47SRPK11.20020253
48PRKD31.19966776
49MAP3K41.17931385
50ILK1.17385255
51HIPK21.14962393
52BMX1.13028471
53INSRR1.12109153
54IRAK21.11661891
55RIPK11.10598816
56ARAF1.08505097
57ITK1.08453190
58PRKAA11.07687792
59FES1.04938930
60FGFR31.04869040
61JAK11.03030832
62PAK21.02371761
63PNCK1.00064629
64STK160.97482486
65MAP4K10.95109450
66IRAK30.94994706
67MAPK70.93099203
68PRKAA20.91975375
69PDK10.91555549
70PDGFRA0.89437169
71LIMK10.88683492
72EPHB20.88029651
73SGK30.87777052
74CAMK2D0.87113952
75ROCK20.85983466
76DAPK10.84301033
77ERBB20.83834320
78ADRBK10.83225743
79MARK10.82853736
80SGK2230.82321305
81SGK4940.82321305
82ICK0.81674866
83DMPK0.79434036
84MYLK0.76657414
85PRKD20.76023257
86DAPK30.75712075
87NTRK10.75431049
88FLT30.75402188
89SGK20.74673452
90CDK80.71081873
91NEK20.70897345
92PRKCB0.70771497
93TESK20.68996360
94PDK40.66500060
95PDK30.66500060
96CDK70.65802847
97EPHB10.65040337
98CSNK1D0.63736140
99RET0.63382054
100MINK10.62374473
101KSR10.61673544
102MAP2K40.61222143
103CAMKK10.59939580
104FGFR40.59392259
105AURKA0.59099079
106MAP3K80.58149271
107TGFBR20.57897967
108CDC42BPA0.56956299
109RPS6KA30.56681902
110STK40.56219114
111CDK30.56162528
112CAMK2G0.54960630
113PRKCZ0.54708253
114FER0.53778875
115PKN10.53263518
116CAMK10.53039228
117ZAP700.52143944
118PRKD10.51868704
119PAK30.51722478
120CDK90.50584698
121PRKACG0.50112965
122TRIM280.49846174
123CAMK40.49436220
124MAPK100.49192230
125STK30.49104008
126PIM20.48795953
127EIF2AK10.46435913
128MAP3K10.46345347
129PIK3CA0.46319351
130PLK10.45712936
131MAPKAPK20.45652220
132KSR20.45114446
133MAP3K90.45062142
134DYRK1A0.44220135
135SGK10.43938636
136MAP3K20.43475136
137CDK190.42658809
138DAPK20.42552823
139DYRK1B0.42265130
140LATS10.41765790
141TAOK10.41568521
142MARK20.40923392
143AURKB0.40810474
144TAOK30.40641790
145CDK50.39281651
146MAPK90.39175653
147PRKG20.38920675
148STK100.38775697
149FGFR10.38387440
150GSK3B0.38236320
151MUSK0.38013330
152RPS6KA40.37898057
153MAP2K70.37781693
154ALK0.37025854
155MAPK80.36526123
156STK110.36050374
157MTOR0.35952285
158STK240.35613231
159ROCK10.35353257
160PRKCI0.33936848
161PDPK10.33903315
162LRRK20.32914892
163ERN10.32540966
164RPS6KA20.32214831
165PLK40.30129311
166PDK20.27550207
167AKT20.27532939
168BMPR20.27152285
169PRKCE0.24749384
170MAP2K10.23696875
171AKT30.23660420
172MELK0.23407572
173SIK30.22723051
174EIF2AK30.22008098
175PRKCD0.21313241
176RPS6KA10.20398248
177MST40.19375700

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.26413711
2Proteasome_Homo sapiens_hsa030503.82944899
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.15091781
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63064448
5RNA polymerase_Homo sapiens_hsa030202.49955132
6Other glycan degradation_Homo sapiens_hsa005112.48913133
7Folate biosynthesis_Homo sapiens_hsa007902.44981276
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.38797587
9Ribosome_Homo sapiens_hsa030102.37333602
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.33433939
11Regulation of autophagy_Homo sapiens_hsa041402.32336626
12ECM-receptor interaction_Homo sapiens_hsa045122.30973663
13Galactose metabolism_Homo sapiens_hsa000522.25177362
14Hedgehog signaling pathway_Homo sapiens_hsa043402.14302038
15Phototransduction_Homo sapiens_hsa0474413.2859180
16Synaptic vesicle cycle_Homo sapiens_hsa047211.81308624
17Olfactory transduction_Homo sapiens_hsa047401.76439562
18Pyrimidine metabolism_Homo sapiens_hsa002401.74089905
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.73565947
20Sphingolipid metabolism_Homo sapiens_hsa006001.66979155
21GABAergic synapse_Homo sapiens_hsa047271.65116135
22Glutathione metabolism_Homo sapiens_hsa004801.60009656
23Lysosome_Homo sapiens_hsa041421.54360018
24Circadian rhythm_Homo sapiens_hsa047101.51883018
25Dilated cardiomyopathy_Homo sapiens_hsa054141.45303655
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.40559526
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34635484
28Morphine addiction_Homo sapiens_hsa050321.26376159
29Cardiac muscle contraction_Homo sapiens_hsa042601.23655199
30Vibrio cholerae infection_Homo sapiens_hsa051101.22821990
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20928395
32Legionellosis_Homo sapiens_hsa051341.20842578
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18957451
34Cholinergic synapse_Homo sapiens_hsa047251.18353020
35RNA transport_Homo sapiens_hsa030131.18047256
36Salmonella infection_Homo sapiens_hsa051321.17658300
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16988226
38Circadian entrainment_Homo sapiens_hsa047131.16514490
39Insulin secretion_Homo sapiens_hsa049111.15203742
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14419354
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14416739
42Shigellosis_Homo sapiens_hsa051311.14343788
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11733619
44Pentose phosphate pathway_Homo sapiens_hsa000301.11693556
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.10897824
46TGF-beta signaling pathway_Homo sapiens_hsa043501.10491897
47Huntingtons disease_Homo sapiens_hsa050161.06401740
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03767190
49Oxytocin signaling pathway_Homo sapiens_hsa049210.97951389
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97930153
51Glutamatergic synapse_Homo sapiens_hsa047240.97263788
52Adherens junction_Homo sapiens_hsa045200.96464368
53Collecting duct acid secretion_Homo sapiens_hsa049660.96376733
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94447354
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93971996
56Nicotine addiction_Homo sapiens_hsa050330.92953017
57Basal transcription factors_Homo sapiens_hsa030220.92574966
58N-Glycan biosynthesis_Homo sapiens_hsa005100.91640505
59Fatty acid elongation_Homo sapiens_hsa000620.91309552
60Dopaminergic synapse_Homo sapiens_hsa047280.89494403
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85680385
62Salivary secretion_Homo sapiens_hsa049700.84499341
63Renin secretion_Homo sapiens_hsa049240.84186877
64mTOR signaling pathway_Homo sapiens_hsa041500.82018088
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81665232
66Protein digestion and absorption_Homo sapiens_hsa049740.81444735
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80797365
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80761306
69Oxidative phosphorylation_Homo sapiens_hsa001900.79967610
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78377084
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77284632
72Prion diseases_Homo sapiens_hsa050200.76093764
73p53 signaling pathway_Homo sapiens_hsa041150.75604299
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74044256
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73672845
76Serotonergic synapse_Homo sapiens_hsa047260.73229887
77Gastric acid secretion_Homo sapiens_hsa049710.71596734
78Hippo signaling pathway_Homo sapiens_hsa043900.66916935
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65498652
80Type II diabetes mellitus_Homo sapiens_hsa049300.65453701
81Calcium signaling pathway_Homo sapiens_hsa040200.64928603
82Base excision repair_Homo sapiens_hsa034100.64620209
83Homologous recombination_Homo sapiens_hsa034400.62256881
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.61786998
85ABC transporters_Homo sapiens_hsa020100.61748380
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61703905
87Parkinsons disease_Homo sapiens_hsa050120.60613617
88Purine metabolism_Homo sapiens_hsa002300.59740454
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59639579
90Arginine and proline metabolism_Homo sapiens_hsa003300.58976509
91Rheumatoid arthritis_Homo sapiens_hsa053230.58240143
92cAMP signaling pathway_Homo sapiens_hsa040240.57947136
93Glucagon signaling pathway_Homo sapiens_hsa049220.57807308
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.57302220
95Bladder cancer_Homo sapiens_hsa052190.55769837
96Viral myocarditis_Homo sapiens_hsa054160.55514222
97Inositol phosphate metabolism_Homo sapiens_hsa005620.55344513
98Allograft rejection_Homo sapiens_hsa053300.54307335
99Ovarian steroidogenesis_Homo sapiens_hsa049130.53510165
100Sulfur relay system_Homo sapiens_hsa041220.52986400
101Autoimmune thyroid disease_Homo sapiens_hsa053200.52980675
102Oocyte meiosis_Homo sapiens_hsa041140.52842817
103Proteoglycans in cancer_Homo sapiens_hsa052050.52624178
104Phenylalanine metabolism_Homo sapiens_hsa003600.51892831
105Lysine degradation_Homo sapiens_hsa003100.51141792
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.51004722
107Long-term potentiation_Homo sapiens_hsa047200.50507466
108Phagosome_Homo sapiens_hsa041450.49703274
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49641085
110HIF-1 signaling pathway_Homo sapiens_hsa040660.48642419
111Mismatch repair_Homo sapiens_hsa034300.48405636
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47772579
113Retinol metabolism_Homo sapiens_hsa008300.47155320
114Thyroid cancer_Homo sapiens_hsa052160.46924914
115Pancreatic secretion_Homo sapiens_hsa049720.46299842
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45421778
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44348721
118VEGF signaling pathway_Homo sapiens_hsa043700.43761679
119Taste transduction_Homo sapiens_hsa047420.42786110
120Insulin resistance_Homo sapiens_hsa049310.41893694
121GnRH signaling pathway_Homo sapiens_hsa049120.41478008
122Spliceosome_Homo sapiens_hsa030400.41460616
123T cell receptor signaling pathway_Homo sapiens_hsa046600.40666408
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40637171
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40086123
126MAPK signaling pathway_Homo sapiens_hsa040100.39966003
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39292146
128Fructose and mannose metabolism_Homo sapiens_hsa000510.39213934
129Epstein-Barr virus infection_Homo sapiens_hsa051690.39136288
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39111970
131Starch and sucrose metabolism_Homo sapiens_hsa005000.38139375
132Insulin signaling pathway_Homo sapiens_hsa049100.36937708
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36862823
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36638438
135AMPK signaling pathway_Homo sapiens_hsa041520.36638340
136Small cell lung cancer_Homo sapiens_hsa052220.36619078
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36558077
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36002736
139Glycerolipid metabolism_Homo sapiens_hsa005610.35669912
140Caffeine metabolism_Homo sapiens_hsa002320.35536779
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34538690
142Glioma_Homo sapiens_hsa052140.34446690
143Metabolic pathways_Homo sapiens_hsa011000.34381898
144mRNA surveillance pathway_Homo sapiens_hsa030150.33880322
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.33397690
146Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31552852
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31419201
148Biosynthesis of amino acids_Homo sapiens_hsa012300.31383568
149Chemokine signaling pathway_Homo sapiens_hsa040620.30464293
150Selenocompound metabolism_Homo sapiens_hsa004500.30013402
151Renal cell carcinoma_Homo sapiens_hsa052110.29784637
152Graft-versus-host disease_Homo sapiens_hsa053320.28635116
153Cell cycle_Homo sapiens_hsa041100.28533662
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27647005
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.27345522
156Choline metabolism in cancer_Homo sapiens_hsa052310.27148705
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26988414
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.25812956
159Nucleotide excision repair_Homo sapiens_hsa034200.25746746
160Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25496881
161Gap junction_Homo sapiens_hsa045400.25455086
162Carbon metabolism_Homo sapiens_hsa012000.24787599
163Alzheimers disease_Homo sapiens_hsa050100.24600174
164Nitrogen metabolism_Homo sapiens_hsa009100.24585393
165ErbB signaling pathway_Homo sapiens_hsa040120.24469581
166Bile secretion_Homo sapiens_hsa049760.24168025
167Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23496648
168Endocytosis_Homo sapiens_hsa041440.22599927
169Non-small cell lung cancer_Homo sapiens_hsa052230.22259590
170Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21558690
171Amphetamine addiction_Homo sapiens_hsa050310.20973827
172Thyroid hormone synthesis_Homo sapiens_hsa049180.20478291
173Tight junction_Homo sapiens_hsa045300.20023955
174Dorso-ventral axis formation_Homo sapiens_hsa043200.19738055
175Ras signaling pathway_Homo sapiens_hsa040140.18956387
176Arginine biosynthesis_Homo sapiens_hsa002200.18729976
177AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16202703
178Focal adhesion_Homo sapiens_hsa045100.14802131
179Colorectal cancer_Homo sapiens_hsa052100.13960032
180Fatty acid biosynthesis_Homo sapiens_hsa000610.12943109

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