FAM193B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.77117114
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64507430
3antigen processing and presentation of endogenous antigen (GO:0019883)4.59725029
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.39171426
5detection of bacterium (GO:0016045)3.94982939
6response to muramyl dipeptide (GO:0032495)3.92362473
7positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.91758611
8detection of other organism (GO:0098543)3.87074115
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.75228730
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.75228730
11modulation by symbiont of host immune response (GO:0052553)3.75228730
12positive regulation by symbiont of host defense response (GO:0052509)3.75228730
13modulation by symbiont of host defense response (GO:0052031)3.75228730
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.75228730
15regulation of cholesterol homeostasis (GO:2000188)3.71819316
16leukocyte aggregation (GO:0070486)3.67871761
17positive regulation of histone deacetylation (GO:0031065)3.67351369
18negative thymic T cell selection (GO:0045060)3.66913019
19regulation of gamma-delta T cell differentiation (GO:0045586)3.62271996
20germinal center formation (GO:0002467)3.55479080
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46419280
22alpha-linolenic acid metabolic process (GO:0036109)3.44700607
23macrophage activation involved in immune response (GO:0002281)3.41258905
24regulation of B cell receptor signaling pathway (GO:0050855)3.39988387
25dicarboxylic acid biosynthetic process (GO:0043650)3.39188532
26locomotory exploration behavior (GO:0035641)3.35418979
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.31346960
28B cell receptor signaling pathway (GO:0050853)3.30899671
29L-phenylalanine catabolic process (GO:0006559)3.27270229
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.27270229
31response to peptidoglycan (GO:0032494)3.26957551
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.20697869
33negative regulation of cell killing (GO:0031342)3.20697869
34regulation of gamma-delta T cell activation (GO:0046643)3.19105585
35detection of external biotic stimulus (GO:0098581)3.15981606
36negative regulation of leukocyte mediated immunity (GO:0002704)3.11902936
37positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11035340
38sodium ion export (GO:0071436)3.10441104
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.10258977
40L-phenylalanine metabolic process (GO:0006558)3.10258977
41regulation of histone H3-K27 methylation (GO:0061085)3.01992746
42neutrophil activation involved in immune response (GO:0002283)3.00694126
43cellular extravasation (GO:0045123)3.00361681
44regulation of ARF GTPase activity (GO:0032312)2.98579545
45regulation of ARF protein signal transduction (GO:0032012)2.98519743
46histone H3-K36 demethylation (GO:0070544)2.97604519
47negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.97244874
48response to interleukin-15 (GO:0070672)2.96361294
49regulation of interferon-beta biosynthetic process (GO:0045357)2.95632384
50positive regulation of Rap GTPase activity (GO:0032854)2.93505117
51regulation of fatty acid beta-oxidation (GO:0031998)2.92706200
52triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.88618677
53tolerance induction (GO:0002507)2.85671474
54antigen processing and presentation via MHC class Ib (GO:0002475)2.85342358
55positive regulation of fatty acid beta-oxidation (GO:0032000)2.83313827
56regulation of T-helper 2 cell differentiation (GO:0045628)2.82098118
57regulation of dendritic cell antigen processing and presentation (GO:0002604)2.81884973
58response to type I interferon (GO:0034340)2.81470160
59alanine transport (GO:0032328)2.81346242
60regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81333453
61synaptic vesicle maturation (GO:0016188)2.80769162
62histone H4 deacetylation (GO:0070933)2.80755995
63positive regulation of gamma-delta T cell activation (GO:0046645)2.78863414
64detection of biotic stimulus (GO:0009595)2.78590960
65histone H3-K4 trimethylation (GO:0080182)2.78563831
66regulation of leukocyte degranulation (GO:0043300)2.77819336
67positive thymic T cell selection (GO:0045059)2.77589496
68regulation of mast cell degranulation (GO:0043304)2.77387293
69cytoskeletal anchoring at plasma membrane (GO:0007016)2.76747106
70negative regulation of innate immune response (GO:0045824)2.76551608
71negative regulation of cholesterol transport (GO:0032375)2.76301856
72negative regulation of sterol transport (GO:0032372)2.76301856
73cellular response to type I interferon (GO:0071357)2.76241898
74type I interferon signaling pathway (GO:0060337)2.76241898
75negative regulation of T cell mediated immunity (GO:0002710)2.75536810
76immunoglobulin mediated immune response (GO:0016064)2.75429075
77positive regulation of protein deacetylation (GO:0090312)2.75108865
78kynurenine metabolic process (GO:0070189)2.74690274
79positive T cell selection (GO:0043368)2.72613534
80response to laminar fluid shear stress (GO:0034616)2.71740956
81regulation of T cell tolerance induction (GO:0002664)2.71443342
823-UTR-mediated mRNA stabilization (GO:0070935)2.70058807
83positive regulation of triglyceride biosynthetic process (GO:0010867)2.69665738
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67762081
85signal complex assembly (GO:0007172)2.67681974
86negative regulation of interleukin-12 production (GO:0032695)2.66771076
87regulation of B cell differentiation (GO:0045577)2.63217059
88mannose metabolic process (GO:0006013)2.62922987
89insulin-like growth factor receptor signaling pathway (GO:0048009)2.62353427
90T cell selection (GO:0045058)2.62166850
91phospholipid scrambling (GO:0017121)2.61324080
92negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.60766662
93regulation of Rap GTPase activity (GO:0032317)2.60747446
94thymic T cell selection (GO:0045061)2.60318803
95aromatic amino acid family catabolic process (GO:0009074)2.60049938
96negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.59555448
97activation of JUN kinase activity (GO:0007257)2.58345827
98glutamate metabolic process (GO:0006536)2.58215010
99positive regulation of glycogen biosynthetic process (GO:0045725)2.57810695
100positive regulation of B cell differentiation (GO:0045579)2.57729977
101pre-miRNA processing (GO:0031054)2.57370798
102negative regulation of type 2 immune response (GO:0002829)2.56760324
103detection of molecule of bacterial origin (GO:0032490)2.56370898
104NIK/NF-kappaB signaling (GO:0038061)2.55339551
105regulation of tolerance induction (GO:0002643)2.54956551
106lysine catabolic process (GO:0006554)2.54599256
107lysine metabolic process (GO:0006553)2.54599256
108regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54216471
109regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53842256
110peptidyl-lysine dimethylation (GO:0018027)2.53664782
111positive regulation of CREB transcription factor activity (GO:0032793)2.53437376
112Peyers patch development (GO:0048541)2.53234176
113mucosal-associated lymphoid tissue development (GO:0048537)2.53234176
114histone H3-K9 demethylation (GO:0033169)2.52767970
115negative regulation of granulocyte differentiation (GO:0030853)2.52583178
116activated T cell proliferation (GO:0050798)2.51901895
117urea metabolic process (GO:0019627)2.51801194
118urea cycle (GO:0000050)2.51801194
119negative regulation of glycoprotein biosynthetic process (GO:0010561)2.50480382
120stress granule assembly (GO:0034063)2.50472131
121defense response to protozoan (GO:0042832)2.49996720
122complement activation, alternative pathway (GO:0006957)2.49130149
123positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.49011479
124positive regulation of Cdc42 GTPase activity (GO:0043089)2.48570730
125histone H3-K9 modification (GO:0061647)2.48041722
126negative regulation of cell size (GO:0045792)2.48023595
1272-oxoglutarate metabolic process (GO:0006103)2.47729906
128natural killer cell differentiation (GO:0001779)2.47682850
129high-density lipoprotein particle remodeling (GO:0034375)2.47482247
130cerebellar Purkinje cell differentiation (GO:0021702)2.47013662
131negative regulation of toll-like receptor signaling pathway (GO:0034122)2.46843337
132histone H3-K4 methylation (GO:0051568)2.46440646
133histone lysine demethylation (GO:0070076)2.46054437
134regulation of mast cell activation involved in immune response (GO:0033006)2.45863923
135positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.45541424
136neutrophil activation (GO:0042119)2.45541255
137histone H3 deacetylation (GO:0070932)2.45300308
138phospholipid homeostasis (GO:0055091)2.45264588
139cellular modified amino acid catabolic process (GO:0042219)2.45042673
140potassium ion import (GO:0010107)2.42853433
141bile acid biosynthetic process (GO:0006699)2.42524918
142positive regulation of glycogen metabolic process (GO:0070875)2.41581085
143regulation of protein activation cascade (GO:2000257)2.41471030
144fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.40238306
145layer formation in cerebral cortex (GO:0021819)2.38959958
146prepulse inhibition (GO:0060134)2.38407947
147negative regulation of fibrinolysis (GO:0051918)2.36225478
148ethanol oxidation (GO:0006069)2.33420339
149cellular potassium ion homeostasis (GO:0030007)2.32629162
150negative regulation of erythrocyte differentiation (GO:0045647)2.31430951
151sulfur amino acid catabolic process (GO:0000098)2.30616196
152synaptic vesicle docking involved in exocytosis (GO:0016081)2.29344319
153cell communication by electrical coupling (GO:0010644)2.29032672
154regulation of triglyceride biosynthetic process (GO:0010866)2.28527335
155positive regulation of triglyceride metabolic process (GO:0090208)2.28478358
156negative regulation of cytosolic calcium ion concentration (GO:0051481)2.26861162
157cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.26543278
158regulation of complement activation (GO:0030449)2.26178165
159negative regulation of cardiac muscle tissue growth (GO:0055022)2.26049112
160negative regulation of heart growth (GO:0061117)2.26049112
161phospholipid efflux (GO:0033700)2.25288265
162activation of protein kinase A activity (GO:0034199)2.25050759
163fatty acid homeostasis (GO:0055089)2.23532080
164glyoxylate metabolic process (GO:0046487)2.23150352
165regulation of fibrinolysis (GO:0051917)2.22949535
166negative regulation of lipid transport (GO:0032369)2.22323698
167tryptophan catabolic process (GO:0006569)2.22284156
168indole-containing compound catabolic process (GO:0042436)2.22284156
169indolalkylamine catabolic process (GO:0046218)2.22284156
170protein carboxylation (GO:0018214)2.22231604
171peptidyl-glutamic acid carboxylation (GO:0017187)2.22231604
172nitrogen cycle metabolic process (GO:0071941)2.22041183
173reverse cholesterol transport (GO:0043691)2.22026242
174negative T cell selection (GO:0043383)2.20924877
175endothelial cell chemotaxis (GO:0035767)2.20062203
176positive regulation of lipid catabolic process (GO:0050996)2.19539570
177cellular sodium ion homeostasis (GO:0006883)2.18251726
178G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.17477960
179cell-substrate adherens junction assembly (GO:0007045)2.15853346
180focal adhesion assembly (GO:0048041)2.15853346
181valine metabolic process (GO:0006573)2.15738311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.63325310
2MYC_22102868_ChIP-Seq_BL_Human2.96060155
3* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.88062587
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.86409481
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.74773453
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.73025229
7KDM2B_26808549_Chip-Seq_DND41_Human2.63321088
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57940801
9LXR_22292898_ChIP-Seq_THP-1_Human2.42356459
10* TCF7_22412390_ChIP-Seq_EML_Mouse2.31723091
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30811533
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.29944685
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.29862470
14VDR_21846776_ChIP-Seq_THP-1_Human2.23027863
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20752331
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20401587
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19919070
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19365533
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16918258
20KDM2B_26808549_Chip-Seq_K562_Human2.16148396
21DROSHA_22980978_ChIP-Seq_HELA_Human2.13245391
22ZFP281_18757296_ChIP-ChIP_E14_Mouse2.02692756
23KDM2B_26808549_Chip-Seq_JURKAT_Human2.01247743
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.95279369
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.93320779
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.88129138
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88040899
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.88038720
29* RUNX1_22412390_ChIP-Seq_EML_Mouse1.86851975
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86157461
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86092800
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85504471
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83470971
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82310435
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81829634
36EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.81134834
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.70936749
38* ELK3_25401928_ChIP-Seq_HUVEC_Human1.70377352
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68836783
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62461158
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60750513
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57734988
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57512258
44* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57031358
45* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54918807
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53461772
47RACK7_27058665_Chip-Seq_MCF-7_Human1.52684876
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.52240635
49UTX_26944678_Chip-Seq_JUKART_Human1.51353065
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.51183564
51CREB1_26743006_Chip-Seq_LNCaP_Human1.51146861
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.47279893
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46704713
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43177915
55MYB_26560356_Chip-Seq_TH1_Human1.41903054
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.41366765
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40748869
58* P68_20966046_ChIP-Seq_HELA_Human1.39203812
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38905617
60MAF_26560356_Chip-Seq_TH1_Human1.37873721
61BCL6_27268052_Chip-Seq_Bcells_Human1.36430480
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33377008
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31901405
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31578982
65MYB_26560356_Chip-Seq_TH2_Human1.30295188
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.29590800
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.27409316
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27091592
69TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.26566211
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.26518465
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25545878
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.24580881
73CLOCK_20551151_ChIP-Seq_293T_Human1.24008426
74SMC4_20622854_ChIP-Seq_HELA_Human1.23749267
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23479988
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22370125
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.22040827
78CTCF_27219007_Chip-Seq_Bcells_Human1.21788316
79GATA1_19941826_ChIP-Seq_K562_Human1.20910722
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.20502748
81SPI1_23547873_ChIP-Seq_NB4_Human1.20139350
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20108959
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20011584
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18553225
85EZH2_22144423_ChIP-Seq_EOC_Human1.18350752
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18259606
87ZNF263_19887448_ChIP-Seq_K562_Human1.15944140
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.15749140
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14871458
90RUNX_20019798_ChIP-Seq_JUKART_Human1.12372108
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11797251
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11643350
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11393633
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10406520
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10360662
96FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07412386
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.07393880
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06415967
99* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05956673
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05898621
101ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05624698
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.05418462
103TBX20_22080862_ChIP-Seq_HEART_Mouse1.05418462
104VDR_24763502_ChIP-Seq_THP-1_Human1.04083277
105TP63_17297297_ChIP-ChIP_HaCaT_Human1.03938583
106NCOR1_26117541_ChIP-Seq_K562_Human1.03064516
107SCL_19346495_ChIP-Seq_HPC-7_Human1.02757030
108PHF8_20622854_ChIP-Seq_HELA_Human1.01414859
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01403088
110TP63_22573176_ChIP-Seq_HFKS_Human1.00716543
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00301499
112SA1_27219007_Chip-Seq_Bcells_Human1.00146723
113* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99931270
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99868838
115MAF_26560356_Chip-Seq_TH2_Human0.99070438
116OCT4_19829295_ChIP-Seq_ESCs_Human0.98943737
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97964668
118CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97767178
119SPI1_23127762_ChIP-Seq_K562_Human0.97479415
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96911232
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96817048
122RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96692088
123EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96692088
124TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96455064
125MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95625292
126SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95304625
127BCOR_27268052_Chip-Seq_Bcells_Human0.94907841
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.94746767
129E2F1_20622854_ChIP-Seq_HELA_Human0.92833552
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92349762
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92153527
132SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92115740
133RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91864300
134* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90128373
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88741595
136CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87981517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.06697314
2MP0003436_decreased_susceptibility_to4.00780968
3MP0005365_abnormal_bile_salt3.82484093
4MP0002139_abnormal_hepatobiliary_system3.59588364
5MP0004859_abnormal_synaptic_plasticity3.43498457
6MP0003724_increased_susceptibility_to3.36722793
7MP0005085_abnormal_gallbladder_physiolo3.12023691
8MP0008961_abnormal_basal_metabolism3.10096570
9MP0003705_abnormal_hypodermis_morpholog2.98916911
10MP0003252_abnormal_bile_duct2.90384030
11MP0002822_catalepsy2.72442130
12MP0001800_abnormal_humoral_immune2.55026264
13MP0001835_abnormal_antigen_presentation2.51443302
14MP0010329_abnormal_lipoprotein_level2.47897197
15MP0005387_immune_system_phenotype2.45907780
16MP0001790_abnormal_immune_system2.45907780
17MP0008875_abnormal_xenobiotic_pharmacok2.42267445
18MP0010234_abnormal_vibrissa_follicle2.40905283
19MP0002419_abnormal_innate_immunity2.37068867
20MP0005025_abnormal_response_to2.32985280
21MP0005000_abnormal_immune_tolerance2.28873872
22MP0008260_abnormal_autophagy2.16179441
23MP0005058_abnormal_lysosome_morphology2.15435998
24MP0002723_abnormal_immune_serum2.15296435
25MP0009278_abnormal_bone_marrow2.14367371
26MP0002420_abnormal_adaptive_immunity2.11205023
27MP0001819_abnormal_immune_cell2.09331733
28MP0003300_gastrointestinal_ulcer2.04642966
29MP0005671_abnormal_response_to2.01872213
30MP0002452_abnormal_antigen_presenting2.00045770
31MP0002396_abnormal_hematopoietic_system1.99210087
32MP0009840_abnormal_foam_cell1.96930204
33MP0009780_abnormal_chondrocyte_physiolo1.92501630
34MP0003191_abnormal_cellular_cholesterol1.92326409
35MP0004130_abnormal_muscle_cell1.89176885
36MP0005083_abnormal_biliary_tract1.86272839
37MP0004381_abnormal_hair_follicle1.86073504
38MP0002909_abnormal_adrenal_gland1.83826214
39MP0002405_respiratory_system_inflammati1.82109855
40MP0002398_abnormal_bone_marrow1.81289939
41MP0001533_abnormal_skeleton_physiology1.77019265
42MP0009333_abnormal_splenocyte_physiolog1.75549909
43MP0010155_abnormal_intestine_physiology1.73655304
44MP0002653_abnormal_ependyma_morphology1.73414199
45MP0000716_abnormal_immune_system1.70702021
46MP0001666_abnormal_nutrient_absorption1.66717326
47MP0001849_ear_inflammation1.66555241
48MP0000569_abnormal_digit_pigmentation1.65854270
49MP0009785_altered_susceptibility_to1.64277410
50MP0002933_joint_inflammation1.59752482
51MP0000609_abnormal_liver_physiology1.54037099
52MP0006082_CNS_inflammation1.51245113
53MP0003635_abnormal_synaptic_transmissio1.50454241
54MP0002118_abnormal_lipid_homeostasis1.45744865
55MP0002722_abnormal_immune_system1.45335211
56MP0005451_abnormal_body_composition1.44631827
57MP0005670_abnormal_white_adipose1.44251660
58MP0003866_abnormal_defecation1.43753701
59MP0003303_peritoneal_inflammation1.42536880
60MP0005409_darkened_coat_color1.38302260
61MP0005464_abnormal_platelet_physiology1.37344836
62MP0004885_abnormal_endolymph1.36225715
63MP0002429_abnormal_blood_cell1.36034637
64MP0000689_abnormal_spleen_morphology1.35933642
65MP0002998_abnormal_bone_remodeling1.35884272
66MP0005397_hematopoietic_system_phenotyp1.35137320
67MP0001545_abnormal_hematopoietic_system1.35137320
68MP0005076_abnormal_cell_differentiation1.34941200
69MP0008569_lethality_at_weaning1.33575112
70MP0003828_pulmonary_edema1.33309717
71MP0008874_decreased_physiological_sensi1.30274501
72MP0001851_eye_inflammation1.29667283
73MP0002132_abnormal_respiratory_system1.29226599
74MP0003283_abnormal_digestive_organ1.28594820
75MP0000003_abnormal_adipose_tissue1.28454694
76MP0005375_adipose_tissue_phenotype1.28167714
77MP0001845_abnormal_inflammatory_respons1.26356779
78MP0000858_altered_metastatic_potential1.25053245
79MP0005666_abnormal_adipose_tissue1.22957595
80MP0003279_aneurysm1.22302149
81MP0003183_abnormal_peptide_metabolism1.19866776
82MP0004185_abnormal_adipocyte_glucose1.19403730
83MP0003075_altered_response_to1.18725932
84MP0004858_abnormal_nervous_system1.18576138
85MP0002148_abnormal_hypersensitivity_rea1.18331193
86MP0003091_abnormal_cell_migration1.14309176
87MP0002928_abnormal_bile_duct1.14232750
88MP0002166_altered_tumor_susceptibility1.13536915
89MP0003329_amyloid_beta_deposits1.12443564
90MP0000678_abnormal_parathyroid_gland1.11689466
91MP0003787_abnormal_imprinting1.11205983
92MP0005167_abnormal_blood-brain_barrier1.09650764
93MP0001958_emphysema1.08653399
94MP0004510_myositis1.08163156
95MP0003045_fibrosis1.07413179
96MP0004808_abnormal_hematopoietic_stem1.05825633
97MP0002254_reproductive_system_inflammat1.05110161
98MP0003453_abnormal_keratinocyte_physiol1.04955636
99MP0005310_abnormal_salivary_gland1.04559421
100MP0002249_abnormal_larynx_morphology1.04358548
101MP0000685_abnormal_immune_system1.03637052
102MP0002009_preneoplasia1.02820583
103MP0003172_abnormal_lysosome_physiology1.01964374
104MP0008469_abnormal_protein_level1.01459756
105MP0003763_abnormal_thymus_physiology1.01160882
106MP0000465_gastrointestinal_hemorrhage1.00195031
107MP0001348_abnormal_lacrimal_gland0.98813948
108MP0002971_abnormal_brown_adipose0.98018300
109MP0010630_abnormal_cardiac_muscle0.97870553
110MP0002063_abnormal_learning/memory/cond0.97274227
111MP0000751_myopathy0.95881247
112MP0003868_abnormal_feces_composition0.95531635
113MP0005332_abnormal_amino_acid0.95318144
114MP0005584_abnormal_enzyme/coenzyme_acti0.93123522
115MP0002078_abnormal_glucose_homeostasis0.93009549
116MP0002089_abnormal_postnatal_growth/wei0.91934131
117MP0002138_abnormal_hepatobiliary_system0.91309693
118MP0005499_abnormal_olfactory_system0.90755591
119MP0005394_taste/olfaction_phenotype0.90755591
120MP0005390_skeleton_phenotype0.89769996
121MP0009672_abnormal_birth_weight0.86340414
122MP0000767_abnormal_smooth_muscle0.86267962
123MP0001663_abnormal_digestive_system0.86235788
124MP0003878_abnormal_ear_physiology0.85167597
125MP0005377_hearing/vestibular/ear_phenot0.85167597
126MP0001984_abnormal_olfaction0.82722167
127MP0002064_seizures0.82465198
128MP0008770_decreased_survivor_rate0.81642325
129MP0010368_abnormal_lymphatic_system0.81408792
130MP0004087_abnormal_muscle_fiber0.81331730
131MP0009745_abnormal_behavioral_response0.79457177
132MP0000703_abnormal_thymus_morphology0.78603644
133MP0004883_abnormal_blood_vessel0.76883135
134MP0005334_abnormal_fat_pad0.76593307
135MP0005187_abnormal_penis_morphology0.76439054
136MP0000249_abnormal_blood_vessel0.76311936
137MP0009115_abnormal_fat_cell0.75129418
138MP0003633_abnormal_nervous_system0.74298579
139MP0004264_abnormal_extraembryonic_tissu0.73650628
140MP0000604_amyloidosis0.73516468
141MP0005319_abnormal_enzyme/_coenzyme0.71794365
142MP0005535_abnormal_body_temperature0.71792960
143MP0002069_abnormal_eating/drinking_beha0.71641573
144MP0003879_abnormal_hair_cell0.70236450
145MP0001986_abnormal_taste_sensitivity0.70175938
146MP0003690_abnormal_glial_cell0.69550902
147MP0001486_abnormal_startle_reflex0.69114135
148MP0009764_decreased_sensitivity_to0.68443025
149MP0003566_abnormal_cell_adhesion0.68413106
150MP0002269_muscular_atrophy0.67941177
151MP0002970_abnormal_white_adipose0.67077217
152MP0005166_decreased_susceptibility_to0.66618576
153MP0003795_abnormal_bone_structure0.66479171
154MP0004947_skin_inflammation0.66328446
155MP0006138_congestive_heart_failure0.65804055
156MP0009931_abnormal_skin_appearance0.65446808
157MP0005220_abnormal_exocrine_pancreas0.64871573
158MP0000598_abnormal_liver_morphology0.64536343
159MP0004811_abnormal_neuron_physiology0.64256306
160MP0005423_abnormal_somatic_nervous0.63681011
161MP0000733_abnormal_muscle_development0.63456224
162MP0009643_abnormal_urine_homeostasis0.62004492
163MP0000747_muscle_weakness0.61913465
164MP0005551_abnormal_eye_electrophysiolog0.60876847
165MP0001873_stomach_inflammation0.60358984
166MP0005448_abnormal_energy_balance0.59914398
167MP0002572_abnormal_emotion/affect_behav0.59004331
168MP0002925_abnormal_cardiovascular_devel0.57924628
169MP0001765_abnormal_ion_homeostasis0.56883345
170MP0004085_abnormal_heartbeat0.55859924
171MP0000266_abnormal_heart_morphology0.55744596
172MP0001502_abnormal_circadian_rhythm0.55738584

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.11063834
2Obstructive sleep apnea (HP:0002870)3.94635223
3Deep venous thrombosis (HP:0002625)3.87171954
4Hyperacusis (HP:0010780)3.65421372
5Increased IgE level (HP:0003212)3.59402388
6Myositis (HP:0100614)3.59239272
7Recurrent bacterial skin infections (HP:0005406)3.46980171
8Recurrent abscess formation (HP:0002722)3.45887294
9Gastrointestinal infarctions (HP:0005244)3.25803900
10Abnormality of the fingertips (HP:0001211)3.23044876
11Abnormality of macrophages (HP:0004311)3.22401594
12Macroorchidism (HP:0000053)3.15810512
13Broad face (HP:0000283)3.05865917
14Abnormality of the lower motor neuron (HP:0002366)3.03446885
15Orchitis (HP:0100796)2.98209236
16Recurrent fungal infections (HP:0002841)2.93517047
17Recurrent gram-negative bacterial infections (HP:0005420)2.89908795
18Gingivitis (HP:0000230)2.88886929
19Elfin facies (HP:0004428)2.87094442
20Cellulitis (HP:0100658)2.86428812
21Cerebral aneurysm (HP:0004944)2.86200702
22Abnormal delayed hypersensitivity skin test (HP:0002963)2.81835261
23Pustule (HP:0200039)2.81373988
24Meningitis (HP:0001287)2.78126250
25Elevated erythrocyte sedimentation rate (HP:0003565)2.77715921
26Obstructive lung disease (HP:0006536)2.74464304
27Chronic obstructive pulmonary disease (HP:0006510)2.74464304
28Insomnia (HP:0100785)2.73677828
29Prolonged bleeding time (HP:0003010)2.72635693
30Metaphyseal cupping (HP:0003021)2.71906103
31Hyperlipoproteinemia (HP:0010980)2.70802382
32Mediastinal lymphadenopathy (HP:0100721)2.68901567
33Renovascular hypertension (HP:0100817)2.67088208
34Broad metatarsal (HP:0001783)2.66828981
35Hemiplegia (HP:0002301)2.66049966
36Pseudobulbar signs (HP:0002200)2.59186294
37Xanthomatosis (HP:0000991)2.59018966
38Optic neuritis (HP:0100653)2.57995290
39Retrobulbar optic neuritis (HP:0100654)2.57995290
40Papilledema (HP:0001085)2.55916678
41Complement deficiency (HP:0004431)2.47812939
42Vertebral arch anomaly (HP:0008438)2.43199136
43Chest pain (HP:0100749)2.41950565
44Emphysema (HP:0002097)2.40000437
45Vasculitis (HP:0002633)2.38753314
46Turricephaly (HP:0000262)2.38383419
47Thin bony cortex (HP:0002753)2.36892146
48Recurrent skin infections (HP:0001581)2.34775176
49Recurrent cutaneous fungal infections (HP:0011370)2.34184766
50Chronic mucocutaneous candidiasis (HP:0002728)2.34184766
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28669112
52Ketosis (HP:0001946)2.28579156
53Back pain (HP:0003418)2.27663043
54Hemorrhage of the eye (HP:0011885)2.26274533
55Easy fatigability (HP:0003388)2.23901144
56Cervical subluxation (HP:0003308)2.23515466
57Intrahepatic cholestasis (HP:0001406)2.22864489
58Colitis (HP:0002583)2.22067266
59Dysostosis multiplex (HP:0000943)2.21973729
60Gastrointestinal stroma tumor (HP:0100723)2.21772878
61Neoplasm of the heart (HP:0100544)2.20441731
62Papilloma (HP:0012740)2.20121344
63Verrucae (HP:0200043)2.20121344
64Hypochromic anemia (HP:0001931)2.19952970
65Aneurysm (HP:0002617)2.18465212
66Hemoptysis (HP:0002105)2.18248210
67Supranuclear gaze palsy (HP:0000605)2.17040376
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15973290
69Abnormality of polysaccharide metabolism (HP:0011012)2.15973290
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15973290
71Stomatitis (HP:0010280)2.15768631
72Epistaxis (HP:0000421)2.13263988
73Abnormality of the thoracic spine (HP:0100711)2.12695116
74Mucopolysacchariduria (HP:0008155)2.12352661
75Urinary glycosaminoglycan excretion (HP:0003541)2.12352661
76Recurrent viral infections (HP:0004429)2.12061214
77Abnormality of monocarboxylic acid metabolism (HP:0010996)2.11864910
78Dysmetric saccades (HP:0000641)2.10365174
79Agammaglobulinemia (HP:0004432)2.10133900
80J-shaped sella turcica (HP:0002680)2.09168859
81Interstitial pulmonary disease (HP:0006530)2.08627365
82Heterotopia (HP:0002282)2.06301971
83Segmental peripheral demyelination/remyelination (HP:0003481)2.06275567
84Malnutrition (HP:0004395)2.05625109
85Encephalitis (HP:0002383)2.05446088
86Lymphangioma (HP:0100764)2.04884033
87Enlarged penis (HP:0000040)2.04852310
88Keratoconjunctivitis sicca (HP:0001097)2.01763714
89Restrictive lung disease (HP:0002091)1.99923870
90Onion bulb formation (HP:0003383)1.99181513
91Impaired social interactions (HP:0000735)1.98729162
92Abnormal social behavior (HP:0012433)1.98729162
93Hypercholesterolemia (HP:0003124)1.98514647
94Pointed chin (HP:0000307)1.97729155
95Polygenic inheritance (HP:0010982)1.95965217
96Obsessive-compulsive behavior (HP:0000722)1.95787235
97Postural instability (HP:0002172)1.95457930
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93595760
99Overriding aorta (HP:0002623)1.92510715
100Thoracic kyphosis (HP:0002942)1.92071491
101Pulmonary infiltrates (HP:0002113)1.90749420
102Panhypogammaglobulinemia (HP:0003139)1.89326970
103Annular pancreas (HP:0001734)1.89007804
104Hypertriglyceridemia (HP:0002155)1.88694414
105Granulocytopenia (HP:0001913)1.88236523
106T lymphocytopenia (HP:0005403)1.88096152
107Status epilepticus (HP:0002133)1.87179688
108Polycythemia (HP:0001901)1.87095992
109Upper limb amyotrophy (HP:0009129)1.86489565
110Distal upper limb amyotrophy (HP:0007149)1.86489565
111Visual hallucinations (HP:0002367)1.86456366
112Gastrointestinal inflammation (HP:0004386)1.85372545
113Osteomyelitis (HP:0002754)1.85327426
114Slow saccadic eye movements (HP:0000514)1.85092274
115Seborrheic dermatitis (HP:0001051)1.84825490
116Renal duplication (HP:0000075)1.84703680
117Long toe (HP:0010511)1.84195127
118Disproportionate tall stature (HP:0001519)1.83843485
119Mitral stenosis (HP:0001718)1.83390764
120Stridor (HP:0010307)1.82783217
121Pulmonary embolism (HP:0002204)1.81266113
122Spastic diplegia (HP:0001264)1.80049939
123Ulnar bowing (HP:0003031)1.79548107
124Keratoconjunctivitis (HP:0001096)1.78741626
125Hypochromic microcytic anemia (HP:0004840)1.78480577
126Lymphopenia (HP:0001888)1.78220035
127Ketoacidosis (HP:0001993)1.77702915
128Abnormality of the diencephalon (HP:0010662)1.77389350
129Shallow orbits (HP:0000586)1.75388569
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75302137
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75189461
132Increased cerebral lipofuscin (HP:0011813)1.74757509
133Mitral valve prolapse (HP:0001634)1.74373393
134Neonatal onset (HP:0003623)1.74307888
135Abnormality of the columella (HP:0009929)1.74295856
136Difficulty running (HP:0009046)1.73621619
137Systemic lupus erythematosus (HP:0002725)1.72160100
138Premature loss of primary teeth (HP:0006323)1.71988634
139Distal lower limb amyotrophy (HP:0008944)1.71415198
140Arnold-Chiari malformation (HP:0002308)1.71236990
141Abnormality of complement system (HP:0005339)1.71223282
142Visceral angiomatosis (HP:0100761)1.71019732
143Peritonitis (HP:0002586)1.70956626
144Ventricular fibrillation (HP:0001663)1.70657488
145Abnormality of T cell number (HP:0011839)1.70010983
146Abnormality of the common coagulation pathway (HP:0010990)1.69892153
147Biconcave vertebral bodies (HP:0004586)1.68696044
148Urticaria (HP:0001025)1.68439466
149Spontaneous hematomas (HP:0007420)1.68366594
150Hemangiomatosis (HP:0007461)1.68279359
151Dislocated radial head (HP:0003083)1.68028682
152Esophageal varix (HP:0002040)1.67747890
153Myocardial infarction (HP:0001658)1.67492254
154Genetic anticipation (HP:0003743)1.67235508
155Abnormality of the peritoneum (HP:0002585)1.66726816
156Focal seizures (HP:0007359)1.66383412
157Gout (HP:0001997)1.65367057
158Inflammation of the large intestine (HP:0002037)1.64604656
159Stroke (HP:0001297)1.64253005
160Exercise-induced myalgia (HP:0003738)1.63606602
161Hyperglycinuria (HP:0003108)1.63550944
162Neuronal loss in central nervous system (HP:0002529)1.62841511
163Abnormality of cells of the lymphoid lineage (HP:0012140)1.62667921
164Epidermoid cyst (HP:0200040)1.62459753
165Arterial thrombosis (HP:0004420)1.62286781
166Hypertensive crisis (HP:0100735)1.61920544
167Myokymia (HP:0002411)1.59779193
168EMG: neuropathic changes (HP:0003445)1.59155590
169Abnormality of the Achilles tendon (HP:0005109)1.58980873
170Flat cornea (HP:0007720)1.56257416
171Hematochezia (HP:0002573)1.56047212
172Precocious puberty (HP:0000826)1.55890737
173Aortic aneurysm (HP:0004942)1.55642064
174Hypoplasia of the thymus (HP:0000778)1.54207502
175Rapidly progressive (HP:0003678)1.53492359
176Reticulocytosis (HP:0001923)1.53440928
177Abnormality of the pancreatic islet cells (HP:0006476)1.53220367
178Abnormality of endocrine pancreas physiology (HP:0012093)1.53220367
179Anal stenosis (HP:0002025)1.53177337
180Hand muscle atrophy (HP:0009130)1.52758165
181Narrow palate (HP:0000189)1.52651290
182Hyperammonemia (HP:0001987)1.52414926
183Depression (HP:0000716)1.51200685
184Cerebral inclusion bodies (HP:0100314)1.50804546
185Generalized hyperpigmentation (HP:0007440)1.50473087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.56270605
2MAP3K103.38131613
3PRPF4B2.99875895
4PKN22.96201262
5SIK22.95602090
6ERN12.65430281
7EEF2K2.48627691
8SIK12.35874245
9ICK2.09664872
10CAMK1G2.09540259
11FGFR42.04834414
12MAP3K72.01601422
13MAP2K31.97045167
14MAP4K11.90655404
15CDK121.81636302
16PTK61.80783028
17MAP3K131.78175567
18BLK1.77457738
19TYRO31.74696272
20FGFR21.71196614
21CAMK1D1.60247831
22SMG11.59630945
23SIK31.59498479
24GRK61.57420931
25DAPK21.54226555
26RIPK11.48532285
27MAP3K91.46641159
28IRAK41.41365642
29JAK31.40751478
30EPHA41.37932463
31MARK21.36746393
32MAP3K61.35292427
33MAP3K141.32117739
34PDGFRA1.31207328
35PRKCH1.25192473
36MAP3K31.25145931
37TTN1.23384386
38TBK11.20851036
39STK381.17960133
40PRKD31.16638036
41BRD41.13796853
42IKBKE1.11783574
43TAOK11.09853138
44NTRK21.06020938
45MTOR1.04281773
46CDC42BPA1.01286227
47KSR21.01166216
48FGFR30.99493230
49PRKD20.98399253
50PAK60.97764959
51TNK20.97460694
52ALK0.96330024
53LRRK20.94335737
54RPS6KL10.92982787
55RPS6KC10.92982787
56MAP3K10.92879651
57SYK0.92832179
58SGK30.91326246
59MAP3K110.90682499
60CAMKK10.89601433
61FES0.89100219
62TXK0.88133108
63RET0.86351313
64DYRK1B0.85652743
65JAK10.84739604
66PDGFRB0.84018387
67EPHB10.82652113
68PRKD10.82624102
69PHKG20.81845884
70PHKG10.81845884
71CAMK40.81110566
72LCK0.79773354
73RPS6KA60.79092157
74BCKDK0.79091421
75ITK0.78285616
76JAK20.78266979
77LMTK20.77630099
78UHMK10.77365840
79HCK0.75901355
80HIPK20.75899959
81NTRK30.75708206
82MAPK120.75272880
83FGR0.74112831
84BMX0.74066425
85KIT0.73689538
86CSF1R0.73567054
87LYN0.73136725
88MAP2K20.72810480
89STK110.72612453
90TGFBR20.71680034
91DMPK0.68632578
92WNK10.68192738
93INSRR0.67548443
94NEK20.65672291
95MAP2K60.65477598
96MAPK110.65273893
97TYK20.65203849
98IKBKB0.64932702
99CDK60.63868804
100CAMK10.62418467
101CSK0.62318451
102TAOK30.61565950
103PTK20.60255617
104MAP2K40.56914044
105ERBB20.56408423
106PRKAA20.56231466
107PDK10.54793456
108FGFR10.52914148
109PDPK10.52799431
110MAPK70.52120787
111PAK30.49774307
112PRKAA10.46457121
113DDR20.46413678
114RPS6KA20.46241887
115CHUK0.46065307
116CDK40.44114979
117ZAP700.44085024
118MAP3K40.43822386
119FYN0.43787380
120CDK50.42498981
121BTK0.42411068
122IRAK30.41943295
123MAP3K20.41557665
124TEC0.40979363
125DAPK10.40668249
126TAOK20.40501140
127PRKCZ0.40261361
128RPS6KA10.40131240
129NLK0.39819670
130EPHA30.38244313
131MARK30.38060497
132MAPK80.37584829
133RIPK40.37343408
134RPS6KA30.37256638
135MAPK150.37243655
136MAPK30.35957476

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.41775216
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61667249
3Other glycan degradation_Homo sapiens_hsa005112.31791221
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.25656085
5Lysine degradation_Homo sapiens_hsa003102.22156185
6Osteoclast differentiation_Homo sapiens_hsa043802.12630474
7Arginine biosynthesis_Homo sapiens_hsa002202.08607546
8Leishmaniasis_Homo sapiens_hsa051401.95631836
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74106620
10Bile secretion_Homo sapiens_hsa049761.68117526
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64884744
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56880990
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48928251
14Graft-versus-host disease_Homo sapiens_hsa053321.48822281
15Allograft rejection_Homo sapiens_hsa053301.48553321
16Olfactory transduction_Homo sapiens_hsa047401.45427291
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42798395
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40505375
19Autoimmune thyroid disease_Homo sapiens_hsa053201.39724230
20Type II diabetes mellitus_Homo sapiens_hsa049301.39016988
21ABC transporters_Homo sapiens_hsa020101.35546235
22Tuberculosis_Homo sapiens_hsa051521.33348185
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.32393058
24Toxoplasmosis_Homo sapiens_hsa051451.31685906
25Fatty acid degradation_Homo sapiens_hsa000711.29746113
26Insulin resistance_Homo sapiens_hsa049311.27927022
27Tryptophan metabolism_Homo sapiens_hsa003801.26688803
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23302724
29Influenza A_Homo sapiens_hsa051641.22301342
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21274481
31PPAR signaling pathway_Homo sapiens_hsa033201.20765322
32Complement and coagulation cascades_Homo sapiens_hsa046101.17921968
33TNF signaling pathway_Homo sapiens_hsa046681.17663059
34Measles_Homo sapiens_hsa051621.17029213
35Notch signaling pathway_Homo sapiens_hsa043301.16533835
36mTOR signaling pathway_Homo sapiens_hsa041501.15943803
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14805006
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.13437536
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11686001
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11381340
41Pancreatic cancer_Homo sapiens_hsa052121.10649801
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10164877
43B cell receptor signaling pathway_Homo sapiens_hsa046621.10090999
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09804076
45Hepatitis C_Homo sapiens_hsa051601.07271875
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07195640
47Herpes simplex infection_Homo sapiens_hsa051681.06582504
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.05860179
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04951469
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04914259
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.04196039
52Hepatitis B_Homo sapiens_hsa051611.03632407
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03362477
54Non-small cell lung cancer_Homo sapiens_hsa052231.03201854
55Prolactin signaling pathway_Homo sapiens_hsa049171.02030659
56Malaria_Homo sapiens_hsa051441.01942447
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.00882995
58Renal cell carcinoma_Homo sapiens_hsa052111.00608726
59Primary immunodeficiency_Homo sapiens_hsa053401.00564916
60Chronic myeloid leukemia_Homo sapiens_hsa052200.99918306
61Gastric acid secretion_Homo sapiens_hsa049710.99871672
62Viral myocarditis_Homo sapiens_hsa054160.99733656
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99494733
64Butanoate metabolism_Homo sapiens_hsa006500.97906176
65Fatty acid metabolism_Homo sapiens_hsa012120.97354427
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95153963
67Type I diabetes mellitus_Homo sapiens_hsa049400.94932260
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94004605
69Circadian entrainment_Homo sapiens_hsa047130.93518483
70Insulin secretion_Homo sapiens_hsa049110.93448109
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93186127
72Hematopoietic cell lineage_Homo sapiens_hsa046400.92444085
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.91926324
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.91570019
75Inositol phosphate metabolism_Homo sapiens_hsa005620.91555781
76Glucagon signaling pathway_Homo sapiens_hsa049220.91371694
77Salivary secretion_Homo sapiens_hsa049700.90369778
78Glioma_Homo sapiens_hsa052140.88935674
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.88724014
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88507052
81Long-term potentiation_Homo sapiens_hsa047200.88275364
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87761263
83Glutamatergic synapse_Homo sapiens_hsa047240.87198748
84Insulin signaling pathway_Homo sapiens_hsa049100.86840629
85Estrogen signaling pathway_Homo sapiens_hsa049150.86495872
86Morphine addiction_Homo sapiens_hsa050320.85161597
87Antigen processing and presentation_Homo sapiens_hsa046120.83654545
88Dorso-ventral axis formation_Homo sapiens_hsa043200.82966095
89GABAergic synapse_Homo sapiens_hsa047270.81801863
90Glycerolipid metabolism_Homo sapiens_hsa005610.81334219
91T cell receptor signaling pathway_Homo sapiens_hsa046600.79847133
92Staphylococcus aureus infection_Homo sapiens_hsa051500.78070220
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.78002645
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77702499
95Caffeine metabolism_Homo sapiens_hsa002320.76932372
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76705678
97Cholinergic synapse_Homo sapiens_hsa047250.76324319
98VEGF signaling pathway_Homo sapiens_hsa043700.76020463
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75692303
100Apoptosis_Homo sapiens_hsa042100.75462905
101Pertussis_Homo sapiens_hsa051330.75182169
102Fatty acid biosynthesis_Homo sapiens_hsa000610.74454347
103Acute myeloid leukemia_Homo sapiens_hsa052210.74171903
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74136281
105Oxytocin signaling pathway_Homo sapiens_hsa049210.73404208
106MAPK signaling pathway_Homo sapiens_hsa040100.73266944
107Endocytosis_Homo sapiens_hsa041440.72823853
108Colorectal cancer_Homo sapiens_hsa052100.72780584
109HTLV-I infection_Homo sapiens_hsa051660.72736733
110Asthma_Homo sapiens_hsa053100.72227118
111AMPK signaling pathway_Homo sapiens_hsa041520.71932858
112Endometrial cancer_Homo sapiens_hsa052130.71828492
113FoxO signaling pathway_Homo sapiens_hsa040680.71432408
114Renin secretion_Homo sapiens_hsa049240.71392190
115Prostate cancer_Homo sapiens_hsa052150.70768373
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70562442
117GnRH signaling pathway_Homo sapiens_hsa049120.70430453
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69852580
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.68566262
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.68142635
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.68119432
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67445585
123Propanoate metabolism_Homo sapiens_hsa006400.67301725
124cAMP signaling pathway_Homo sapiens_hsa040240.66980402
125Dopaminergic synapse_Homo sapiens_hsa047280.66347317
126African trypanosomiasis_Homo sapiens_hsa051430.65888939
127Choline metabolism in cancer_Homo sapiens_hsa052310.64324530
128Amoebiasis_Homo sapiens_hsa051460.64314198
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62345777
130ErbB signaling pathway_Homo sapiens_hsa040120.61502361
131Cocaine addiction_Homo sapiens_hsa050300.61019358
132Thyroid hormone synthesis_Homo sapiens_hsa049180.60911289
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60538082
134HIF-1 signaling pathway_Homo sapiens_hsa040660.57777373
135Amphetamine addiction_Homo sapiens_hsa050310.57295042
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56875138
137Viral carcinogenesis_Homo sapiens_hsa052030.56235542
138Starch and sucrose metabolism_Homo sapiens_hsa005000.54208512
139Biosynthesis of amino acids_Homo sapiens_hsa012300.53938492
140Bladder cancer_Homo sapiens_hsa052190.53201411
141Lysosome_Homo sapiens_hsa041420.53011130
142Phagosome_Homo sapiens_hsa041450.52758804
143Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52179784
144Melanogenesis_Homo sapiens_hsa049160.51983363
145Fat digestion and absorption_Homo sapiens_hsa049750.51957225
146Prion diseases_Homo sapiens_hsa050200.51791074
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.51429511
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51094691
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50940877
150Ras signaling pathway_Homo sapiens_hsa040140.50937294
151Calcium signaling pathway_Homo sapiens_hsa040200.50922713
152Dilated cardiomyopathy_Homo sapiens_hsa054140.50370355
153Proteoglycans in cancer_Homo sapiens_hsa052050.48729628
154Rap1 signaling pathway_Homo sapiens_hsa040150.48698502
155Pancreatic secretion_Homo sapiens_hsa049720.48209231
156Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47771210
157Platelet activation_Homo sapiens_hsa046110.46799583
158beta-Alanine metabolism_Homo sapiens_hsa004100.46413127
159Chemokine signaling pathway_Homo sapiens_hsa040620.45043034

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