FAM188A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)5.09320549
2protein K11-linked deubiquitination (GO:0035871)4.45748971
3neurofilament cytoskeleton organization (GO:0060052)4.32140809
4neuron cell-cell adhesion (GO:0007158)4.17651186
5long-chain fatty acid biosynthetic process (GO:0042759)4.07872635
6positive regulation of mitochondrial fission (GO:0090141)3.90408590
7negative regulation of dendrite morphogenesis (GO:0050774)3.87099444
8cullin deneddylation (GO:0010388)3.70440353
9acrosome assembly (GO:0001675)3.68310273
10neuronal action potential propagation (GO:0019227)3.61578894
11regulation of axon regeneration (GO:0048679)3.54954942
12regulation of neuron projection regeneration (GO:0070570)3.54954942
13glutamate secretion (GO:0014047)3.48313148
14intraciliary transport (GO:0042073)3.48263573
15positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.45928378
16chaperone-mediated protein transport (GO:0072321)3.43977102
17synaptic vesicle exocytosis (GO:0016079)3.43868715
18response to methylmercury (GO:0051597)3.41466998
19protein localization to cilium (GO:0061512)3.39053457
20protein neddylation (GO:0045116)3.35042510
21negative regulation of neurotransmitter transport (GO:0051589)3.30504681
22neural tube formation (GO:0001841)3.29090745
23neurotransmitter-gated ion channel clustering (GO:0072578)3.27717032
24retinal cone cell development (GO:0046549)3.24242243
25negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18660107
26detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.18261378
27detection of temperature stimulus involved in sensory perception (GO:0050961)3.18261378
28dopamine biosynthetic process (GO:0042416)3.16616577
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16395209
30establishment of mitochondrion localization (GO:0051654)3.14129378
31negative regulation of homotypic cell-cell adhesion (GO:0034111)3.11285845
32cholesterol biosynthetic process (GO:0006695)3.06340393
33membrane assembly (GO:0071709)3.05888976
34negative regulation of complement activation (GO:0045916)3.04768861
35neuron recognition (GO:0008038)3.04447346
36negative regulation of calcium ion transport into cytosol (GO:0010523)3.04351016
37presynaptic membrane assembly (GO:0097105)3.01539971
38long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.01194605
39vesicle transport along microtubule (GO:0047496)2.97874288
40positive regulation of actin filament depolymerization (GO:0030836)2.96915094
41neuron remodeling (GO:0016322)2.92777354
42negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.91053721
43ribonucleoprotein complex disassembly (GO:0032988)2.90470698
44axon ensheathment in central nervous system (GO:0032291)2.89953165
45central nervous system myelination (GO:0022010)2.89953165
46detection of temperature stimulus (GO:0016048)2.88478766
47peripheral nervous system neuron development (GO:0048935)2.87267063
48axonal fasciculation (GO:0007413)2.86277580
49protein localization to synapse (GO:0035418)2.85521292
50regulation of cilium movement (GO:0003352)2.85092321
51calcium-mediated signaling using intracellular calcium source (GO:0035584)2.85072576
52regulation of dendritic spine morphogenesis (GO:0061001)2.83690209
53epithelial cilium movement (GO:0003351)2.83538561
54innervation (GO:0060384)2.81402603
55regulation of synapse structural plasticity (GO:0051823)2.80998644
56peroxisome fission (GO:0016559)2.80847106
57long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.77952520
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77686341
59negative regulation of protein activation cascade (GO:2000258)2.77402753
60retinal ganglion cell axon guidance (GO:0031290)2.77166230
61regulation of synaptic vesicle exocytosis (GO:2000300)2.77120060
62positive regulation of dendritic spine morphogenesis (GO:0061003)2.76928401
63regulation of meiosis I (GO:0060631)2.76910402
64negative regulation of dendrite development (GO:2000171)2.76477361
65nonmotile primary cilium assembly (GO:0035058)2.76302123
66organelle transport along microtubule (GO:0072384)2.75923931
67cilium morphogenesis (GO:0060271)2.75915017
68regulation of vesicle fusion (GO:0031338)2.74755589
69organelle disassembly (GO:1903008)2.74615067
70sterol biosynthetic process (GO:0016126)2.74188042
71regulation of collateral sprouting (GO:0048670)2.72445562
72positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.71125955
73dendritic spine morphogenesis (GO:0060997)2.70866220
74cell migration in hindbrain (GO:0021535)2.70314804
75proteasome assembly (GO:0043248)2.70267121
76protein prenylation (GO:0018342)2.69995874
77prenylation (GO:0097354)2.69995874
78gamma-aminobutyric acid transport (GO:0015812)2.69838365
79pyrimidine nucleobase catabolic process (GO:0006208)2.68664019
80presynaptic membrane organization (GO:0097090)2.68221867
81lipid particle organization (GO:0034389)2.67883986
82postsynaptic membrane organization (GO:0001941)2.67699089
83detection of mechanical stimulus involved in sensory perception (GO:0050974)2.67641834
84central nervous system projection neuron axonogenesis (GO:0021952)2.67338795
85negative regulation of neurotransmitter secretion (GO:0046929)2.67059682
86behavioral response to ethanol (GO:0048149)2.66716668
87substantia nigra development (GO:0021762)2.65691764
88desmosome organization (GO:0002934)2.65598929
89negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.65551049
90serotonin receptor signaling pathway (GO:0007210)2.65439487
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.64944155
92L-phenylalanine catabolic process (GO:0006559)2.64944155
93negative regulation of acute inflammatory response (GO:0002674)2.63543427
94auditory behavior (GO:0031223)2.62589666
95positive regulation of mitochondrial membrane permeability (GO:0035794)2.62172158
96gamma-aminobutyric acid signaling pathway (GO:0007214)2.61287585
97glutamate receptor signaling pathway (GO:0007215)2.60338099
98cellular copper ion homeostasis (GO:0006878)2.59140198
99ATP hydrolysis coupled proton transport (GO:0015991)2.57483765
100energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.57483765
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57248832
102ER overload response (GO:0006983)2.56379835
103vocalization behavior (GO:0071625)2.55785005
104central nervous system neuron axonogenesis (GO:0021955)2.55606311
105fatty-acyl-CoA metabolic process (GO:0035337)2.55339477
106positive regulation of protein depolymerization (GO:1901881)2.55133557
107neuronal action potential (GO:0019228)2.54640467
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.53482571
109righting reflex (GO:0060013)2.53408680
110DNA double-strand break processing (GO:0000729)2.52807665
111axon development (GO:0061564)2.52225274
112regulation of neuronal synaptic plasticity (GO:0048168)2.52151156
113regulation of synaptic vesicle transport (GO:1902803)2.51765203
114regulation of dendritic spine development (GO:0060998)2.50680718
115long-term synaptic potentiation (GO:0060291)2.50618638
116regulation of pigment cell differentiation (GO:0050932)2.49983251
117nucleobase catabolic process (GO:0046113)2.49187841
118response to redox state (GO:0051775)2.49039475
119negative regulation of axonogenesis (GO:0050771)2.48530389
120mechanosensory behavior (GO:0007638)2.48514788
121negative regulation of axon guidance (GO:1902668)2.47394632
122positive regulation of synapse assembly (GO:0051965)2.46632794
123establishment of protein localization to Golgi (GO:0072600)2.46213604
124protein targeting to Golgi (GO:0000042)2.46069931
125synaptic vesicle endocytosis (GO:0048488)2.44744498
126glycosphingolipid biosynthetic process (GO:0006688)2.44604319
127cilium assembly (GO:0042384)2.44588192
128cilium movement (GO:0003341)2.44439986
129mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.44022660
130positive regulation of muscle hypertrophy (GO:0014742)2.43896151
131positive regulation of cardiac muscle hypertrophy (GO:0010613)2.43896151
132regulation of long-term neuronal synaptic plasticity (GO:0048169)2.43457819
133magnesium ion transport (GO:0015693)2.42461975
134cilium organization (GO:0044782)2.41578438
135regulation of short-term neuronal synaptic plasticity (GO:0048172)2.41422250
136ionotropic glutamate receptor signaling pathway (GO:0035235)2.41390199
137proline transport (GO:0015824)2.41189997
138positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.40868333
139establishment of vesicle localization (GO:0051650)2.40636132
140response to pheromone (GO:0019236)2.40067537
141regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.39829920
142piRNA metabolic process (GO:0034587)2.39582625
143regulation of acyl-CoA biosynthetic process (GO:0050812)2.39579064
144synapse assembly (GO:0007416)2.39049479
145protein localization to endosome (GO:0036010)2.38765711
146protein deneddylation (GO:0000338)2.36548071
147fatty-acyl-CoA biosynthetic process (GO:0046949)2.36240409
148hippocampus development (GO:0021766)2.36067332
149regulation of glutamate secretion (GO:0014048)2.35977014
150olfactory bulb development (GO:0021772)2.35674021
151negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.35489825
152regulation of synaptic plasticity (GO:0048167)2.34432122
153regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.34295489
154regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.32632423
155regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.32478551
156vascular smooth muscle contraction (GO:0014829)2.31472683
157establishment of melanosome localization (GO:0032401)2.31205161
158positive regulation of gastrulation (GO:2000543)2.30009524
159attachment of spindle microtubules to kinetochore (GO:0008608)2.29508584
160regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.29458095
161synaptic vesicle maturation (GO:0016188)2.29209332
162regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.26450392
163regulation of mitotic spindle checkpoint (GO:1903504)2.26450392
164sequestering of actin monomers (GO:0042989)2.25664172
165microtubule anchoring (GO:0034453)2.25245411
166regulation of mitochondrial fission (GO:0090140)2.24512813
167spermatid nucleus differentiation (GO:0007289)2.24412221
168dopamine transport (GO:0015872)2.24130323
169regulation of synapse assembly (GO:0051963)2.23837191
170protein polyglutamylation (GO:0018095)2.23705044
171dendritic spine organization (GO:0097061)2.23084614
172melanosome transport (GO:0032402)2.23047528
173regulation of synaptic transmission, glutamatergic (GO:0051966)2.22659783
174positive regulation of dendritic spine development (GO:0060999)2.22622206
175cerebral cortex radially oriented cell migration (GO:0021799)2.19356355
176retrograde transport, vesicle recycling within Golgi (GO:0000301)2.19189931
177regulation of coenzyme metabolic process (GO:0051196)2.18992130
178regulation of cofactor metabolic process (GO:0051193)2.18992130
179short-term memory (GO:0007614)2.18209422
180detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.17957666
181microtubule-based transport (GO:0010970)2.17114463
182transmission of nerve impulse (GO:0019226)2.16849616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.07399567
2TAF15_26573619_Chip-Seq_HEK293_Human3.11110332
3EZH2_22144423_ChIP-Seq_EOC_Human2.79334112
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.79164795
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57641391
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55597069
7AR_21572438_ChIP-Seq_LNCaP_Human2.41379063
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36792333
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33193622
10VDR_22108803_ChIP-Seq_LS180_Human2.32622077
11P300_19829295_ChIP-Seq_ESCs_Human2.30837621
12SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.22408110
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22348562
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20388226
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12951062
16FUS_26573619_Chip-Seq_HEK293_Human2.06894231
17OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.03258370
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00707991
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00451907
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97487889
21SMAD4_21799915_ChIP-Seq_A2780_Human1.97024257
22* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96523735
23TOP2B_26459242_ChIP-Seq_MCF-7_Human1.93279549
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.88794785
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88626980
26* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86317986
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85077401
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83153752
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74100101
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71203529
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.70875534
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69807388
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68562002
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68421841
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.67963448
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67939176
37TP53_18474530_ChIP-ChIP_U2OS_Human1.67277254
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66481088
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66481088
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65513226
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64375270
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64375270
43* SMAD3_21741376_ChIP-Seq_EPCs_Human1.64133721
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.62864448
45PRDM14_20953172_ChIP-Seq_ESCs_Human1.59689051
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59159661
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.58490031
48IGF1R_20145208_ChIP-Seq_DFB_Human1.56648553
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53520509
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52584549
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51615490
52AR_25329375_ChIP-Seq_VCAP_Human1.50408743
53CBP_20019798_ChIP-Seq_JUKART_Human1.49806611
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49806611
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48515930
56ER_23166858_ChIP-Seq_MCF-7_Human1.46914066
57STAT3_23295773_ChIP-Seq_U87_Human1.44930225
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.44866924
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.44278254
60BCAT_22108803_ChIP-Seq_LS180_Human1.43976396
61JUN_21703547_ChIP-Seq_K562_Human1.43540148
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42725636
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42253004
64EWS_26573619_Chip-Seq_HEK293_Human1.40282472
65ELK1_19687146_ChIP-ChIP_HELA_Human1.36747873
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36288106
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36032926
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35645320
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34373493
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33583145
71REST_21632747_ChIP-Seq_MESCs_Mouse1.33260684
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32283873
73* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31530306
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.31376599
75* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31261647
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.30757354
77AHR_22903824_ChIP-Seq_MCF-7_Human1.30204464
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28944150
79* NANOG_18555785_Chip-Seq_ESCs_Mouse1.28717885
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.28522187
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27041948
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.26086841
83RUNX2_22187159_ChIP-Seq_PCA_Human1.25914627
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25100998
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23930854
86RNF2_27304074_Chip-Seq_NSC_Mouse1.23875677
87TCF4_22108803_ChIP-Seq_LS180_Human1.22946124
88GABP_17652178_ChIP-ChIP_JURKAT_Human1.22148779
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.21681304
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19885818
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19590692
92ZNF274_21170338_ChIP-Seq_K562_Hela1.19347863
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19230695
94* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19163218
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.17893407
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16811310
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16672707
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16089749
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16066300
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15685317
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.15671838
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.15600445
103KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15577779
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15303511
105* CMYC_18555785_Chip-Seq_ESCs_Mouse1.15284274
106FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14880389
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14359285
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14359285
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14307907
110KDM2B_26808549_Chip-Seq_REH_Human1.14086187
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13479425
112NANOG_19829295_ChIP-Seq_ESCs_Human1.13054264
113SOX2_19829295_ChIP-Seq_ESCs_Human1.13054264
114IRF1_19129219_ChIP-ChIP_H3396_Human1.12495553
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11768732
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11738628
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09905256
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09030672
119RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07811127
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07749884
121TCF4_23295773_ChIP-Seq_U87_Human1.07631866
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.07478848
123* E2F1_18555785_Chip-Seq_ESCs_Mouse1.07376759
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06548428
125* P53_22387025_ChIP-Seq_ESCs_Mouse1.06169903
126NFE2_27457419_Chip-Seq_LIVER_Mouse1.05906384
127TP53_16413492_ChIP-PET_HCT116_Human1.05344522
128EP300_21415370_ChIP-Seq_HL-1_Mouse1.05197452
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03919857
130CJUN_26792858_Chip-Seq_BT549_Human1.03809601
131* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03285398
132TRIM28_21343339_ChIP-Seq_HEK293_Human1.02639877
133REST_18959480_ChIP-ChIP_MESCs_Mouse1.02450179
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.00902253
135NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00692404
136LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00627021
137* TAL1_26923725_Chip-Seq_HPCs_Mouse1.00199210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.60140289
2MP0004270_analgesia4.03697867
3MP0002735_abnormal_chemical_nociception3.92223334
4MP0002736_abnormal_nociception_after3.90109555
5MP0001968_abnormal_touch/_nociception3.67970774
6MP0004859_abnormal_synaptic_plasticity3.53722479
7MP0006276_abnormal_autonomic_nervous2.90654479
8MP0005360_urolithiasis2.84698549
9MP0003329_amyloid_beta_deposits2.68554212
10MP0002734_abnormal_mechanical_nocicepti2.64112977
11MP0003635_abnormal_synaptic_transmissio2.37608833
12MP0003136_yellow_coat_color2.33872945
13MP0001986_abnormal_taste_sensitivity2.30039170
14MP0000569_abnormal_digit_pigmentation2.29544659
15MP0002733_abnormal_thermal_nociception2.25428217
16MP0001529_abnormal_vocalization2.23409313
17MP0002102_abnormal_ear_morphology2.21390737
18MP0002063_abnormal_learning/memory/cond2.12868291
19MP0005499_abnormal_olfactory_system2.08114790
20MP0005394_taste/olfaction_phenotype2.08114790
21MP0002272_abnormal_nervous_system2.03347843
22MP0008789_abnormal_olfactory_epithelium2.02984020
23MP0000372_irregular_coat_pigmentation2.02209913
24MP0002796_impaired_skin_barrier2.02106010
25MP0009379_abnormal_foot_pigmentation2.01767104
26MP0005187_abnormal_penis_morphology1.96412457
27MP0001970_abnormal_pain_threshold1.96011702
28MP0005171_absent_coat_pigmentation1.94730283
29MP0008877_abnormal_DNA_methylation1.93765032
30MP0002184_abnormal_innervation1.90310456
31MP0002064_seizures1.85613765
32MP0006072_abnormal_retinal_apoptosis1.85121729
33MP0001440_abnormal_grooming_behavior1.82777250
34MP0001984_abnormal_olfaction1.82010652
35MP0003890_abnormal_embryonic-extraembry1.80705581
36MP0003806_abnormal_nucleotide_metabolis1.79302798
37MP0002572_abnormal_emotion/affect_behav1.78884781
38MP0004381_abnormal_hair_follicle1.77395120
39MP0001905_abnormal_dopamine_level1.75648389
40MP0002234_abnormal_pharynx_morphology1.73206364
41MP0009780_abnormal_chondrocyte_physiolo1.72924059
42MP0009745_abnormal_behavioral_response1.69930231
43MP0000920_abnormal_myelination1.69308361
44MP0005084_abnormal_gallbladder_morpholo1.69100193
45MP0000778_abnormal_nervous_system1.69088044
46MP0005451_abnormal_body_composition1.67977709
47MP0000604_amyloidosis1.67870481
48MP0002067_abnormal_sensory_capabilities1.64945622
49MP0009697_abnormal_copulation1.64413496
50MP0002139_abnormal_hepatobiliary_system1.61220299
51MP0009046_muscle_twitch1.55234645
52MP0004858_abnormal_nervous_system1.50072627
53MP0001486_abnormal_startle_reflex1.48552461
54MP0005551_abnormal_eye_electrophysiolog1.47846709
55MP0005253_abnormal_eye_physiology1.47523698
56MP0006054_spinal_hemorrhage1.46356082
57MP0001501_abnormal_sleep_pattern1.42202728
58MP0005085_abnormal_gallbladder_physiolo1.41995952
59MP0008058_abnormal_DNA_repair1.39407168
60MP0000579_abnormal_nail_morphology1.39377729
61MP0004142_abnormal_muscle_tone1.38255664
62MP0005408_hypopigmentation1.35035635
63MP0003950_abnormal_plasma_membrane1.33967142
64MP0010386_abnormal_urinary_bladder1.30877960
65MP0008875_abnormal_xenobiotic_pharmacok1.26915652
66MP0002160_abnormal_reproductive_system1.26911549
67MP0000955_abnormal_spinal_cord1.25604635
68MP0002295_abnormal_pulmonary_circulatio1.22679541
69MP0000427_abnormal_hair_cycle1.21339676
70MP0002638_abnormal_pupillary_reflex1.19893565
71MP0010234_abnormal_vibrissa_follicle1.19307872
72MP0004215_abnormal_myocardial_fiber1.17992790
73MP0001299_abnormal_eye_distance/1.15625808
74MP0005275_abnormal_skin_tensile1.15104219
75MP0003634_abnormal_glial_cell1.14235803
76MP0006292_abnormal_olfactory_placode1.12918747
77MP0001293_anophthalmia1.11883341
78MP0005386_behavior/neurological_phenoty1.11379561
79MP0004924_abnormal_behavior1.11379561
80MP0010771_integument_phenotype1.10626604
81MP0004742_abnormal_vestibular_system1.08309613
82MP0002882_abnormal_neuron_morphology1.08183309
83MP0003121_genomic_imprinting1.06287114
84MP0004885_abnormal_endolymph1.05869495
85MP0000631_abnormal_neuroendocrine_gland1.05361139
86MP0003221_abnormal_cardiomyocyte_apopto1.04524218
87MP0002229_neurodegeneration1.03970007
88MP0002233_abnormal_nose_morphology1.03631683
89MP0005423_abnormal_somatic_nervous1.03044474
90MP0001879_abnormal_lymphatic_vessel1.02617874
91MP0004811_abnormal_neuron_physiology1.02011201
92MP0003632_abnormal_nervous_system1.01742182
93MP0001542_abnormal_bone_strength1.00331430
94MP0002090_abnormal_vision0.98967180
95MP0000538_abnormal_urinary_bladder0.96718184
96MP0008057_abnormal_DNA_replication0.94278902
97MP0002751_abnormal_autonomic_nervous0.94028468
98MP0002928_abnormal_bile_duct0.93240775
99MP0005503_abnormal_tendon_morphology0.93069782
100MP0003718_maternal_effect0.93056719
101MP0001188_hyperpigmentation0.92334170
102MP0002066_abnormal_motor_capabilities/c0.91134043
103MP0003937_abnormal_limbs/digits/tail_de0.90753218
104MP0000647_abnormal_sebaceous_gland0.89792599
105MP0004145_abnormal_muscle_electrophysio0.88880846
106MP0005395_other_phenotype0.88026377
107MP0003631_nervous_system_phenotype0.87541620
108MP0010368_abnormal_lymphatic_system0.86087771
109MP0005083_abnormal_biliary_tract0.84917404
110MP0005391_vision/eye_phenotype0.84880445
111MP0004085_abnormal_heartbeat0.84795465
112MP0002009_preneoplasia0.84236234
113MP0003195_calcinosis0.83758869
114MP0003385_abnormal_body_wall0.83552481
115MP0002557_abnormal_social/conspecific_i0.82981693
116MP0003252_abnormal_bile_duct0.82712862
117MP0002752_abnormal_somatic_nervous0.80828811
118MP0003879_abnormal_hair_cell0.80813240
119MP0002822_catalepsy0.80068289
120MP0008932_abnormal_embryonic_tissue0.80053158
121MP0002152_abnormal_brain_morphology0.80023359
122MP0005367_renal/urinary_system_phenotyp0.79557405
123MP0000516_abnormal_urinary_system0.79557405
124MP0001929_abnormal_gametogenesis0.79556119
125MP0001485_abnormal_pinna_reflex0.79248180
126MP0010678_abnormal_skin_adnexa0.78883569
127MP0001177_atelectasis0.78731787
128MP0005248_abnormal_Harderian_gland0.78452621
129MP0003567_abnormal_fetal_cardiomyocyte0.77682750
130MP0001340_abnormal_eyelid_morphology0.77591183
131MP0003698_abnormal_male_reproductive0.77131986
132MP0005501_abnormal_skin_physiology0.76865501
133MP0000049_abnormal_middle_ear0.76053567
134MP0001963_abnormal_hearing_physiology0.75996134
135MP0005195_abnormal_posterior_eye0.75990773
136MP0005165_increased_susceptibility_to0.75375128
137MP0003861_abnormal_nervous_system0.74612329
138MP0002177_abnormal_outer_ear0.74140254
139MP0003935_abnormal_craniofacial_develop0.73836147
140MP0003755_abnormal_palate_morphology0.73798343
141MP0005409_darkened_coat_color0.73167320
142MP0003633_abnormal_nervous_system0.71964982
143MP0009384_cardiac_valve_regurgitation0.68896215
144MP0003656_abnormal_erythrocyte_physiolo0.67663219
145MP0004147_increased_porphyrin_level0.66185902
146MP0005595_abnormal_vascular_smooth0.65963152
147MP0008874_decreased_physiological_sensi0.61041701
148MP0005646_abnormal_pituitary_gland0.58722141
149MP0000026_abnormal_inner_ear0.58674586
150MP0004883_abnormal_blood_vessel0.58418196
151MP0005197_abnormal_uvea_morphology0.57036889
152MP0001851_eye_inflammation0.55371392

Predicted human phenotypes

RankGene SetZ-score
1Termporal pattern (HP:0011008)4.65016801
2Insidious onset (HP:0003587)4.65016801
3Ulnar claw (HP:0001178)4.45211525
4Myokymia (HP:0002411)3.97850139
5Atonic seizures (HP:0010819)3.94602923
6Neurofibrillary tangles (HP:0002185)3.82033810
7Papillary thyroid carcinoma (HP:0002895)3.59799947
8Focal motor seizures (HP:0011153)3.56796173
9Parakeratosis (HP:0001036)3.50737816
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.48056646
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.48056646
12Cerebral inclusion bodies (HP:0100314)3.47099496
13Delusions (HP:0000746)3.35120598
14Short tibia (HP:0005736)3.34503513
15Aplasia/Hypoplasia of the tibia (HP:0005772)3.30554322
16Abnormality of the corticospinal tract (HP:0002492)3.24949931
17Autoamputation (HP:0001218)3.24217601
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.22556134
19Pheochromocytoma (HP:0002666)3.14333081
20Drooling (HP:0002307)3.12915352
21Hypothermia (HP:0002045)3.12461406
22Nephrogenic diabetes insipidus (HP:0009806)3.08986293
23Abnormality of midbrain morphology (HP:0002418)3.02242686
24Molar tooth sign on MRI (HP:0002419)3.02242686
25Neuroendocrine neoplasm (HP:0100634)2.98118445
26Sensory axonal neuropathy (HP:0003390)2.97217849
27Focal seizures (HP:0007359)2.96204106
28Retinal dysplasia (HP:0007973)2.93842123
29Acute necrotizing encephalopathy (HP:0006965)2.90750532
30Volvulus (HP:0002580)2.89839886
31Pancreatic fibrosis (HP:0100732)2.87446368
32Congenital ichthyosiform erythroderma (HP:0007431)2.83989947
33Hyperventilation (HP:0002883)2.82821868
34Bifid tongue (HP:0010297)2.81346076
35Supranuclear gaze palsy (HP:0000605)2.81116354
36Action tremor (HP:0002345)2.78723708
37Excessive salivation (HP:0003781)2.76559327
38Segmental peripheral demyelination/remyelination (HP:0003481)2.74936102
39Cerebral hemorrhage (HP:0001342)2.73568530
40Nephronophthisis (HP:0000090)2.72975502
41Progressive macrocephaly (HP:0004481)2.69783240
42Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.67593125
43Renal cortical cysts (HP:0000803)2.66676051
44Absent speech (HP:0001344)2.60377300
45Thyroid carcinoma (HP:0002890)2.60340002
46Absence seizures (HP:0002121)2.58609485
47Febrile seizures (HP:0002373)2.58217920
48Acute encephalopathy (HP:0006846)2.55555101
49Abnormal gallbladder physiology (HP:0012438)2.55216758
50Cholecystitis (HP:0001082)2.55216758
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.54169029
52Amyotrophic lateral sclerosis (HP:0007354)2.51834717
53Tubulointerstitial nephritis (HP:0001970)2.46016002
54Median cleft lip (HP:0000161)2.45646857
55Pancreatic cysts (HP:0001737)2.42283405
56Delayed gross motor development (HP:0002194)2.36729924
57Dialeptic seizures (HP:0011146)2.36605471
58Steppage gait (HP:0003376)2.34201883
59Hammertoe (HP:0001765)2.32570635
60Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.31971446
61Polyphagia (HP:0002591)2.30307059
62Abnormal mitochondria in muscle tissue (HP:0008316)2.30303262
63Limb dystonia (HP:0002451)2.28227764
64Spastic tetraplegia (HP:0002510)2.28008933
65True hermaphroditism (HP:0010459)2.26174737
66Increased serum pyruvate (HP:0003542)2.26105594
67Abnormality of glycolysis (HP:0004366)2.26105594
68Epileptic encephalopathy (HP:0200134)2.25894259
69Dysautonomia (HP:0002459)2.25851447
70Dysmetria (HP:0001310)2.25755747
71Mitochondrial inheritance (HP:0001427)2.24934975
72Generalized tonic-clonic seizures (HP:0002069)2.23599652
73Progressive cerebellar ataxia (HP:0002073)2.23540510
74Curly hair (HP:0002212)2.23096807
75Anomalous pulmonary venous return (HP:0010772)2.22086325
76Abnormality of the renal medulla (HP:0100957)2.19208631
77Blue irides (HP:0000635)2.18501396
78Akinesia (HP:0002304)2.15652273
79Postaxial foot polydactyly (HP:0001830)2.13961890
80Myelomeningocele (HP:0002475)2.13658218
81Genital tract atresia (HP:0001827)2.13280790
82Metaphyseal dysplasia (HP:0100255)2.13082489
83Abnormal autonomic nervous system physiology (HP:0012332)2.12453714
84Adrenal hypoplasia (HP:0000835)2.11867169
85Abnormality of the labia minora (HP:0012880)2.11139529
86Broad-based gait (HP:0002136)2.08952011
87Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08864514
88Postaxial hand polydactyly (HP:0001162)2.08173251
89Narrow forehead (HP:0000341)2.07254438
90Poor coordination (HP:0002370)2.07192879
91Abnormal biliary tract physiology (HP:0012439)2.07097183
92Bile duct proliferation (HP:0001408)2.07097183
93Lissencephaly (HP:0001339)2.06760158
94Generalized myoclonic seizures (HP:0002123)2.05955358
95Spastic gait (HP:0002064)2.05803504
96Short foot (HP:0001773)2.02897911
97Impaired vibration sensation in the lower limbs (HP:0002166)2.02864312
98Atrophy/Degeneration involving motor neurons (HP:0007373)2.02432106
99Scanning speech (HP:0002168)2.02146217
100Vaginal atresia (HP:0000148)2.01565245
101Pachygyria (HP:0001302)2.00990059
102Thickened helices (HP:0000391)2.00906620
103Gait imbalance (HP:0002141)2.00192875
104Specific learning disability (HP:0001328)2.00021744
105Onion bulb formation (HP:0003383)1.98110042
106Choroideremia (HP:0001139)1.97177079
107Distal sensory impairment (HP:0002936)1.96549232
108Inability to walk (HP:0002540)1.95984852
109Oculomotor apraxia (HP:0000657)1.94554701
110Renal Fanconi syndrome (HP:0001994)1.94507422
111Chronic hepatic failure (HP:0100626)1.94028971
112Hypoplasia of the fovea (HP:0007750)1.93980076
113Aplasia/Hypoplasia of the fovea (HP:0008060)1.93980076
114Abnormality of the renal cortex (HP:0011035)1.93809566
115Leukodystrophy (HP:0002415)1.93608601
116Abnormality of the pulmonary veins (HP:0011718)1.92772426
117Type II lissencephaly (HP:0007260)1.92515849
118Hypsarrhythmia (HP:0002521)1.92431493
119Progressive inability to walk (HP:0002505)1.91318908
120Cerebral edema (HP:0002181)1.91139188
121Decreased testicular size (HP:0008734)1.90034937
122Abnormality of the fovea (HP:0000493)1.89869943
123Medial flaring of the eyebrow (HP:0010747)1.88810225
124Microglossia (HP:0000171)1.87632392
125Foot dorsiflexor weakness (HP:0009027)1.87444421
126Aplasia/Hypoplasia of the lens (HP:0008063)1.86951705
127Gaze-evoked nystagmus (HP:0000640)1.86561293
128Submucous cleft hard palate (HP:0000176)1.86379184
129Facial shape deformation (HP:0011334)1.85751921
130Potter facies (HP:0002009)1.85751921
131Amblyopia (HP:0000646)1.84675010
132Intrahepatic cholestasis (HP:0001406)1.84657218
133Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82548641
134Epileptiform EEG discharges (HP:0011182)1.82396769
135Truncal ataxia (HP:0002078)1.81794825
136Spastic paraparesis (HP:0002313)1.81267673
137Facial hemangioma (HP:0000329)1.81210448
138Xerostomia (HP:0000217)1.81090399
139Abnormal hair whorl (HP:0010721)1.80998125
140Increased hepatocellular lipid droplets (HP:0006565)1.80920957
141X-linked dominant inheritance (HP:0001423)1.80622206
142Small hand (HP:0200055)1.80475694
143Abnormality of macular pigmentation (HP:0008002)1.80262460
144Anterior segment dysgenesis (HP:0007700)1.80156771
145Methylmalonic acidemia (HP:0002912)1.79895350
146Congenital primary aphakia (HP:0007707)1.79665620
147Decreased motor nerve conduction velocity (HP:0003431)1.79303462
148Cortical dysplasia (HP:0002539)1.79153810
149Disproportionate short-trunk short stature (HP:0003521)1.77543242
150Micropenis (HP:0000054)1.77462492
151Hepatocellular necrosis (HP:0001404)1.77387268
152Poor speech (HP:0002465)1.77186111
153Increased CSF lactate (HP:0002490)1.75528904
154Lower limb muscle weakness (HP:0007340)1.74720367
155Lipid accumulation in hepatocytes (HP:0006561)1.72902246
156Abnormality of renal resorption (HP:0011038)1.72465722
157Deep venous thrombosis (HP:0002625)1.72432654
158Abnormality of the astrocytes (HP:0100707)1.71097358
159Astrocytoma (HP:0009592)1.71097358
160Gonadotropin excess (HP:0000837)1.70731710
161Hypoplastic pelvis (HP:0008839)1.69794619
162Supernumerary spleens (HP:0009799)1.69794132
163Optic nerve hypoplasia (HP:0000609)1.69206780
164Prolonged partial thromboplastin time (HP:0003645)1.67562994
165Occipital encephalocele (HP:0002085)1.66950406
166Aqueductal stenosis (HP:0002410)1.66019352
167Cerebral hypomyelination (HP:0006808)1.65736527
168Hypophosphatemic rickets (HP:0004912)1.65020352
169EEG with generalized epileptiform discharges (HP:0011198)1.64971315
170Anencephaly (HP:0002323)1.63953989
171Large earlobe (HP:0009748)1.63576738
172Peripheral hypomyelination (HP:0007182)1.63455693
173Tubulointerstitial abnormality (HP:0001969)1.63324941
174Dysdiadochokinesis (HP:0002075)1.61939297
175Muscular hypotonia of the trunk (HP:0008936)1.61161956
176Broad foot (HP:0001769)1.60531428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.55449205
2MAP3K93.11159330
3WNK33.01835549
4TRIM282.83625493
5NTRK32.78125894
6EPHA42.51352566
7KSR22.49086761
8MAP2K72.42538172
9LIMK12.41931589
10ARAF2.40105053
11TNIK2.37795574
12MINK12.37598151
13STK392.33058004
14MAP4K22.30826993
15CASK2.29816048
16NTRK12.26256939
17RIPK42.25808303
18BCR2.15984349
19GRK52.11071275
20BMPR22.04237304
21MAP3K41.91637969
22MST41.91442576
23EIF2AK31.89863105
24PLK21.81635139
25MAP2K41.81020655
26ERBB41.75400487
27NME11.72510600
28SRPK11.69148842
29LATS21.63718482
30MAPKAPK51.60927694
31CAMKK21.59006056
32KSR11.48084053
33OXSR11.47755297
34BRD41.46418915
35BMPR1B1.43377224
36SIK31.40195296
37MAP3K131.36681514
38FER1.34495044
39MAP3K21.34369381
40ACVR1B1.30772256
41MAP3K61.30746720
42STK38L1.26341838
43CAMK2B1.22146362
44PNCK1.17215514
45FGR1.17138163
46RAF11.16449170
47PLK31.14795673
48WNK41.14329670
49PTK2B1.14133164
50PRPF4B1.13923854
51MOS1.09864082
52MARK11.09120013
53CAMK2A1.08997144
54MAPKAPK31.08968059
55BRAF1.08903121
56SGK2231.03910558
57SGK4941.03910558
58DYRK21.02379341
59GRK71.02094553
60YES11.00009291
61MAPK130.99609018
62GRK10.97744070
63DYRK30.96617233
64BRSK20.96116740
65MET0.94179873
66TRPM70.91515170
67FRK0.90859843
68PAK60.90330892
69CDK50.85924828
70PINK10.83465907
71ADRBK20.82686918
72CSNK1G20.80748240
73PAK30.79924941
74CDK140.79722827
75MST1R0.79610456
76MAP3K50.79293952
77ERBB30.76563743
78RET0.75554215
79STK240.75313808
80DAPK20.75061785
81CSNK1G30.74977296
82TNK20.71889395
83INSRR0.70941979
84CAMK2G0.68679735
85ZAK0.68410997
86PRKCG0.67799659
87MAP2K10.67533973
88FGFR20.64494336
89WNK10.64469483
90LATS10.64064362
91PRKCE0.64013117
92ROCK20.63293853
93EPHA30.62972906
94ABL20.62969176
95CDK180.62151867
96CSNK1A1L0.61942563
97NUAK10.61206654
98UHMK10.60208421
99MAP3K10.60079326
100DYRK1A0.57567078
101MKNK20.56978275
102PRKCQ0.56436519
103CAMK2D0.55696758
104PLK40.55424609
105EIF2AK10.54443986
106STK160.53820184
107MKNK10.53687465
108CCNB10.53016133
109TGFBR10.53013162
110SGK20.50243063
111CDK150.50149825
112TSSK60.47738899
113TESK10.45021509
114ADRBK10.44617175
115WEE10.44431784
116NEK90.44329405
117AURKA0.44235653
118EPHB20.44185974
119PBK0.44109872
120NEK60.43983205
121CSNK1G10.43408679
122CSNK1D0.43073287
123STK30.42589476
124PLK10.42009875
125STK380.41519910
126PHKG20.40551862
127PHKG10.40551862
128AKT30.40541761
129PRKACB0.40517952
130PRKG10.40042519
131DAPK10.39147239
132VRK10.38677523
133FES0.38561888
134ATM0.37519057
135PKN10.37388945
136CDK11A0.36989520
137RPS6KA40.36831325
138CAMK40.36664001
139NTRK20.33496912
140FYN0.30202948
141TAOK30.29406272
142CDK80.29179697

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.12659901
2Oxidative phosphorylation_Homo sapiens_hsa001902.44201715
3Nicotine addiction_Homo sapiens_hsa050332.39696773
4Collecting duct acid secretion_Homo sapiens_hsa049662.31078767
5Fatty acid elongation_Homo sapiens_hsa000622.24322670
6Synaptic vesicle cycle_Homo sapiens_hsa047212.20020394
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17564147
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06697618
9Long-term potentiation_Homo sapiens_hsa047202.02052748
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89205850
11Non-homologous end-joining_Homo sapiens_hsa034501.88396201
12Alzheimers disease_Homo sapiens_hsa050101.87315722
13Basal transcription factors_Homo sapiens_hsa030221.86756587
14Circadian rhythm_Homo sapiens_hsa047101.84511266
15Serotonergic synapse_Homo sapiens_hsa047261.84090430
16Ether lipid metabolism_Homo sapiens_hsa005651.83641382
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80374133
18Olfactory transduction_Homo sapiens_hsa047401.75150449
19Dopaminergic synapse_Homo sapiens_hsa047281.70409746
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69486190
21Glutamatergic synapse_Homo sapiens_hsa047241.66416831
22Amphetamine addiction_Homo sapiens_hsa050311.60528013
23Long-term depression_Homo sapiens_hsa047301.55012611
24Regulation of autophagy_Homo sapiens_hsa041401.54364167
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53850247
26Parkinsons disease_Homo sapiens_hsa050121.52442017
27Sulfur metabolism_Homo sapiens_hsa009201.49265667
28Vibrio cholerae infection_Homo sapiens_hsa051101.44635234
29Axon guidance_Homo sapiens_hsa043601.43754828
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42254870
31Circadian entrainment_Homo sapiens_hsa047131.39882968
32GABAergic synapse_Homo sapiens_hsa047271.39375164
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.38134500
34Taste transduction_Homo sapiens_hsa047421.37717479
35RNA degradation_Homo sapiens_hsa030181.37664559
36Salivary secretion_Homo sapiens_hsa049701.36070083
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34504773
38GnRH signaling pathway_Homo sapiens_hsa049121.31848745
39Histidine metabolism_Homo sapiens_hsa003401.22282359
40Cholinergic synapse_Homo sapiens_hsa047251.19556729
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17945269
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17323458
43Caffeine metabolism_Homo sapiens_hsa002321.16525424
44Dorso-ventral axis formation_Homo sapiens_hsa043201.15231797
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14215348
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14152519
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13501591
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12346498
49Renin secretion_Homo sapiens_hsa049241.11813238
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06958492
51Tyrosine metabolism_Homo sapiens_hsa003501.06655989
52Morphine addiction_Homo sapiens_hsa050321.05831243
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04109933
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03753030
55Huntingtons disease_Homo sapiens_hsa050161.03592633
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02092660
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97662740
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.95692018
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94484810
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94334562
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94273120
62ErbB signaling pathway_Homo sapiens_hsa040120.92626762
63Phagosome_Homo sapiens_hsa041450.92625658
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90935333
65Gastric acid secretion_Homo sapiens_hsa049710.89570165
66Ras signaling pathway_Homo sapiens_hsa040140.89274268
67Fanconi anemia pathway_Homo sapiens_hsa034600.89030667
68Glioma_Homo sapiens_hsa052140.88604450
69Linoleic acid metabolism_Homo sapiens_hsa005910.88313640
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87269177
71Sphingolipid metabolism_Homo sapiens_hsa006000.87160660
72Gap junction_Homo sapiens_hsa045400.86853966
73Folate biosynthesis_Homo sapiens_hsa007900.86606413
74Butanoate metabolism_Homo sapiens_hsa006500.84176224
75RNA transport_Homo sapiens_hsa030130.83873444
76p53 signaling pathway_Homo sapiens_hsa041150.83308091
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82815983
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81466909
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.81388331
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80090909
81Protein export_Homo sapiens_hsa030600.79779708
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78447166
83Proteasome_Homo sapiens_hsa030500.76011847
84Choline metabolism in cancer_Homo sapiens_hsa052310.75846234
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75399374
86Hedgehog signaling pathway_Homo sapiens_hsa043400.75068282
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74548582
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72246285
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71229919
90Oxytocin signaling pathway_Homo sapiens_hsa049210.70599040
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.69221591
92RNA polymerase_Homo sapiens_hsa030200.68714488
93Phototransduction_Homo sapiens_hsa047440.68460152
94Insulin secretion_Homo sapiens_hsa049110.66889860
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66461045
96Pyruvate metabolism_Homo sapiens_hsa006200.65431300
97Rheumatoid arthritis_Homo sapiens_hsa053230.65210801
98Mineral absorption_Homo sapiens_hsa049780.65008481
99Melanogenesis_Homo sapiens_hsa049160.63981333
100Alcoholism_Homo sapiens_hsa050340.59631408
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59346964
102Nucleotide excision repair_Homo sapiens_hsa034200.59222816
103VEGF signaling pathway_Homo sapiens_hsa043700.58984752
104Purine metabolism_Homo sapiens_hsa002300.57689352
105Calcium signaling pathway_Homo sapiens_hsa040200.57620612
106Pancreatic secretion_Homo sapiens_hsa049720.55443441
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54507958
108cAMP signaling pathway_Homo sapiens_hsa040240.54384526
109Cell cycle_Homo sapiens_hsa041100.54119163
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53906215
111Renal cell carcinoma_Homo sapiens_hsa052110.53518370
112Peroxisome_Homo sapiens_hsa041460.52326591
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51920686
114Vitamin B6 metabolism_Homo sapiens_hsa007500.51915291
115mRNA surveillance pathway_Homo sapiens_hsa030150.51808756
116Complement and coagulation cascades_Homo sapiens_hsa046100.51376609
117Estrogen signaling pathway_Homo sapiens_hsa049150.51263400
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50217705
119Phenylalanine metabolism_Homo sapiens_hsa003600.49635854
120TGF-beta signaling pathway_Homo sapiens_hsa043500.49109740
121Chemical carcinogenesis_Homo sapiens_hsa052040.49038002
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48053026
123African trypanosomiasis_Homo sapiens_hsa051430.46642950
124Fatty acid biosynthesis_Homo sapiens_hsa000610.45756126
125Endocytosis_Homo sapiens_hsa041440.45529059
126Oocyte meiosis_Homo sapiens_hsa041140.45430998
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45270075
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45150119
129Propanoate metabolism_Homo sapiens_hsa006400.44695308
130Melanoma_Homo sapiens_hsa052180.44481143
131Fatty acid metabolism_Homo sapiens_hsa012120.44189767
132Mismatch repair_Homo sapiens_hsa034300.42929225
133Ovarian steroidogenesis_Homo sapiens_hsa049130.42911328
134Hippo signaling pathway_Homo sapiens_hsa043900.42059214
135Arginine and proline metabolism_Homo sapiens_hsa003300.41153102
136Shigellosis_Homo sapiens_hsa051310.40501454
137Metabolic pathways_Homo sapiens_hsa011000.39396214
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.39370693
139Nitrogen metabolism_Homo sapiens_hsa009100.38444323
140Bile secretion_Homo sapiens_hsa049760.38360598
141Cocaine addiction_Homo sapiens_hsa050300.38157677
142Rap1 signaling pathway_Homo sapiens_hsa040150.37403165

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