FAM182B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)5.60561300
2cilium or flagellum-dependent cell motility (GO:0001539)5.47790763
3cilium movement (GO:0003341)5.33879750
4epithelial cilium movement (GO:0003351)5.33555549
5motile cilium assembly (GO:0044458)5.00639823
6sperm motility (GO:0030317)4.88278074
7protein polyglutamylation (GO:0018095)4.81475477
8acrosome reaction (GO:0007340)4.58056303
9regulation of cilium movement (GO:0003352)4.45891385
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.28479996
11axoneme assembly (GO:0035082)4.19308904
12microtubule depolymerization (GO:0007019)4.14768231
13postsynaptic membrane organization (GO:0001941)4.10259232
14response to pheromone (GO:0019236)3.97885213
15behavioral response to nicotine (GO:0035095)3.74342896
16spermatid development (GO:0007286)3.63677270
17microtubule polymerization or depolymerization (GO:0031109)3.61527074
18nonmotile primary cilium assembly (GO:0035058)3.61181717
19cilium organization (GO:0044782)3.54540538
20piRNA metabolic process (GO:0034587)3.53401478
21cilium assembly (GO:0042384)3.50842973
22cellular ketone body metabolic process (GO:0046950)3.44741609
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.43564166
24multicellular organism reproduction (GO:0032504)3.39436595
25positive regulation of meiosis (GO:0045836)3.38767187
26intraciliary transport (GO:0042073)3.32397881
27response to nitrosative stress (GO:0051409)3.22510460
28regulation of microtubule-based movement (GO:0060632)3.20162308
29calcium ion-dependent exocytosis (GO:0017156)3.19650530
30sperm-egg recognition (GO:0035036)3.19131744
31presynaptic membrane assembly (GO:0097105)3.18413007
32regulation of meiosis I (GO:0060631)3.18044152
33positive regulation of meiotic cell cycle (GO:0051446)3.17063664
34male meiosis (GO:0007140)3.16730041
35retinal cone cell development (GO:0046549)3.14469387
36detection of light stimulus involved in sensory perception (GO:0050962)3.14370635
37detection of light stimulus involved in visual perception (GO:0050908)3.14370635
38transmission of nerve impulse (GO:0019226)3.13781719
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11427682
40synapsis (GO:0007129)3.10422806
41regulation of neurotransmitter uptake (GO:0051580)3.08832379
42cilium morphogenesis (GO:0060271)3.08703276
43fusion of sperm to egg plasma membrane (GO:0007342)3.08179415
44cerebral cortex radially oriented cell migration (GO:0021799)3.06263412
45ketone body metabolic process (GO:1902224)3.02436555
46auditory behavior (GO:0031223)2.97341387
47primary amino compound metabolic process (GO:1901160)2.92935295
48tongue development (GO:0043586)2.84843965
49cellular component assembly involved in morphogenesis (GO:0010927)2.79496883
50DNA methylation involved in gamete generation (GO:0043046)2.79350841
51negative regulation of astrocyte differentiation (GO:0048712)2.78772377
52photoreceptor cell maintenance (GO:0045494)2.77621105
53prepulse inhibition (GO:0060134)2.76367241
54sperm capacitation (GO:0048240)2.76028232
55male meiosis I (GO:0007141)2.75091677
56centriole replication (GO:0007099)2.74303296
57neuron cell-cell adhesion (GO:0007158)2.74127450
58protein localization to synapse (GO:0035418)2.70765489
59mechanosensory behavior (GO:0007638)2.70500512
60serotonin metabolic process (GO:0042428)2.69016437
61male gamete generation (GO:0048232)2.68091216
62gamma-aminobutyric acid transport (GO:0015812)2.67881032
63spermatogenesis (GO:0007283)2.67748805
64left/right axis specification (GO:0070986)2.66300909
65retinal rod cell development (GO:0046548)2.66238130
66presynaptic membrane organization (GO:0097090)2.65677414
67binding of sperm to zona pellucida (GO:0007339)2.64979948
68microtubule bundle formation (GO:0001578)2.63319463
69single strand break repair (GO:0000012)2.61041200
70one-carbon compound transport (GO:0019755)2.60965537
71artery development (GO:0060840)2.60643318
72spermatid nucleus differentiation (GO:0007289)2.59068521
73cell morphogenesis involved in neuron differentiation (GO:0048667)2.56953012
74plasma membrane fusion (GO:0045026)2.56903380
75auditory receptor cell stereocilium organization (GO:0060088)2.56072560
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53437514
77cell-cell recognition (GO:0009988)2.52313719
78reproduction (GO:0000003)2.51919930
79membrane depolarization during action potential (GO:0086010)2.51811811
80centriole assembly (GO:0098534)2.51567499
81gamete generation (GO:0007276)2.51309804
82neuromuscular synaptic transmission (GO:0007274)2.49059232
83response to auditory stimulus (GO:0010996)2.48371444
84outer ear morphogenesis (GO:0042473)2.47648721
85single fertilization (GO:0007338)2.46041657
86chromosome organization involved in meiosis (GO:0070192)2.45991532
87behavioral response to cocaine (GO:0048148)2.45593859
88inner ear receptor stereocilium organization (GO:0060122)2.45015586
89neurotransmitter catabolic process (GO:0042135)2.44707654
90ventricular system development (GO:0021591)2.44684488
91microtubule severing (GO:0051013)2.43897547
92regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.43256781
93regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.43256781
94smoothened signaling pathway (GO:0007224)2.39465761
95glycerophospholipid catabolic process (GO:0046475)2.36741584
96fertilization (GO:0009566)2.35643813
97reflex (GO:0060004)2.32496632
98coenzyme catabolic process (GO:0009109)2.31920487
99neuronal action potential (GO:0019228)2.31110679
100negative regulation of synaptic transmission, GABAergic (GO:0032229)2.29582515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.78353712
2GBX2_23144817_ChIP-Seq_PC3_Human3.34288221
3IGF1R_20145208_ChIP-Seq_DFB_Human3.23467344
4ZNF274_21170338_ChIP-Seq_K562_Hela3.01148616
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.90123666
6VDR_22108803_ChIP-Seq_LS180_Human2.89848171
7* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.77617589
8* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.50802762
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31301615
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21462996
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15840058
12FUS_26573619_Chip-Seq_HEK293_Human2.04842990
13TAF15_26573619_Chip-Seq_HEK293_Human1.99706588
14* ER_23166858_ChIP-Seq_MCF-7_Human1.91558375
15P300_19829295_ChIP-Seq_ESCs_Human1.88480703
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86542113
17AR_21572438_ChIP-Seq_LNCaP_Human1.84675051
18REST_21632747_ChIP-Seq_MESCs_Mouse1.71621387
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.70293916
20SMAD4_21799915_ChIP-Seq_A2780_Human1.69422576
21TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69248644
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69248644
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67444356
24STAT3_23295773_ChIP-Seq_U87_Human1.63192012
25CBP_20019798_ChIP-Seq_JUKART_Human1.62495198
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62495198
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61019702
28DROSHA_22980978_ChIP-Seq_HELA_Human1.56296903
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52560180
30AR_25329375_ChIP-Seq_VCAP_Human1.51934804
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48964026
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48511221
33KLF5_20875108_ChIP-Seq_MESCs_Mouse1.47679937
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47292891
35EWS_26573619_Chip-Seq_HEK293_Human1.45496631
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.43155151
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42755956
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42025036
39RUNX2_22187159_ChIP-Seq_PCA_Human1.39919663
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.39821427
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39278092
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.38955482
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37152504
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36552988
45TCF4_23295773_ChIP-Seq_U87_Human1.35460095
46RNF2_27304074_Chip-Seq_NSC_Mouse1.34153788
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34107752
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.32522229
49BCAT_22108803_ChIP-Seq_LS180_Human1.32466679
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.31464569
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30463634
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29784620
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25776641
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24466692
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23831142
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.23831142
57NCOR_22424771_ChIP-Seq_293T_Human1.22147589
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21356777
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.21122710
60SOX2_19829295_ChIP-Seq_ESCs_Human1.21037774
61NANOG_19829295_ChIP-Seq_ESCs_Human1.21037774
62TCF4_22108803_ChIP-Seq_LS180_Human1.21037047
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.20872375
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20554417
65WDR5_24793694_ChIP-Seq_LNCAP_Human1.20508895
66MYC_19829295_ChIP-Seq_ESCs_Human1.20379092
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19375863
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19049160
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19032690
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18941391
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18576799
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17914966
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16334975
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16063828
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.15848304
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15490685
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13652889
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.11507083
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11052242
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09544086
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09492600
82TBL1_22424771_ChIP-Seq_293T_Human1.07548334
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07424485
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07106631
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06934394
86TP53_22573176_ChIP-Seq_HFKS_Human1.06868534
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.05883856
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04764322
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04561395
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04456272
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02601077
92ERA_21632823_ChIP-Seq_H3396_Human1.02521577
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02297616
94HOXB7_26014856_ChIP-Seq_BT474_Human1.01625740
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.00470099
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99991851
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.99392727
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.99123682
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98867280
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98468206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.51834486
2MP0000566_synostosis3.28074467
3MP0001984_abnormal_olfaction2.65589663
4MP0006292_abnormal_olfactory_placode2.61101938
5MP0009046_muscle_twitch2.51214998
6MP0001968_abnormal_touch/_nociception2.47199135
7MP0003136_yellow_coat_color2.35312657
8MP0005551_abnormal_eye_electrophysiolog2.30553255
9MP0002736_abnormal_nociception_after2.20669000
10MP0001486_abnormal_startle_reflex2.04313935
11MP0009745_abnormal_behavioral_response2.03494107
12MP0003698_abnormal_male_reproductive2.01703188
13MP0008789_abnormal_olfactory_epithelium1.95351808
14MP0005646_abnormal_pituitary_gland1.94348334
15MP0002735_abnormal_chemical_nociception1.88598611
16MP0001529_abnormal_vocalization1.86849873
17MP0002272_abnormal_nervous_system1.84121778
18MP0002572_abnormal_emotion/affect_behav1.82544287
19MP0003635_abnormal_synaptic_transmissio1.81011545
20MP0004885_abnormal_endolymph1.80460512
21MP0002234_abnormal_pharynx_morphology1.79462157
22MP0001929_abnormal_gametogenesis1.78300894
23MP0002734_abnormal_mechanical_nocicepti1.78166499
24MP0004270_analgesia1.76282027
25MP0004859_abnormal_synaptic_plasticity1.76094462
26MP0006276_abnormal_autonomic_nervous1.76008502
27MP0003011_delayed_dark_adaptation1.75270140
28MP0005253_abnormal_eye_physiology1.71089677
29MP0002653_abnormal_ependyma_morphology1.70233507
30MP0005423_abnormal_somatic_nervous1.69570976
31MP0002064_seizures1.67410521
32MP0005499_abnormal_olfactory_system1.65627511
33MP0005394_taste/olfaction_phenotype1.65627511
34MP0006072_abnormal_retinal_apoptosis1.64374939
35MP0002638_abnormal_pupillary_reflex1.61659269
36MP0004742_abnormal_vestibular_system1.60272031
37MP0002063_abnormal_learning/memory/cond1.59666207
38MP0001970_abnormal_pain_threshold1.59132371
39MP0001501_abnormal_sleep_pattern1.56972182
40MP0002557_abnormal_social/conspecific_i1.56905178
41MP0002067_abnormal_sensory_capabilities1.55240774
42MP0002733_abnormal_thermal_nociception1.55087912
43MP0000631_abnormal_neuroendocrine_gland1.49449855
44MP0001485_abnormal_pinna_reflex1.47029400
45MP0000026_abnormal_inner_ear1.40870993
46MP0008877_abnormal_DNA_methylation1.40849411
47MP0003878_abnormal_ear_physiology1.37569430
48MP0005377_hearing/vestibular/ear_phenot1.37569430
49MP0001905_abnormal_dopamine_level1.35281026
50MP0001502_abnormal_circadian_rhythm1.34639166
51MP0000569_abnormal_digit_pigmentation1.31648942
52MP0002249_abnormal_larynx_morphology1.30693132
53MP0003880_abnormal_central_pattern1.30612058
54MP0008875_abnormal_xenobiotic_pharmacok1.22939443
55MP0002938_white_spotting1.22118396
56MP0001963_abnormal_hearing_physiology1.19192883
57MP0003283_abnormal_digestive_organ1.18511064
58MP0002210_abnormal_sex_determination1.18212988
59MP0000778_abnormal_nervous_system1.17787782
60MP0009780_abnormal_chondrocyte_physiolo1.16714251
61MP0003718_maternal_effect1.15963041
62MP0004142_abnormal_muscle_tone1.14279774
63MP0002229_neurodegeneration1.14225004
64MP0008872_abnormal_physiological_respon1.10907600
65MP0001440_abnormal_grooming_behavior1.10732277
66MP0000678_abnormal_parathyroid_gland1.08110604
67MP0005174_abnormal_tail_pigmentation1.07878394
68MP0000427_abnormal_hair_cycle1.05331948
69MP0004043_abnormal_pH_regulation1.04349919
70MP0002161_abnormal_fertility/fecundity1.03771926
71MP0000653_abnormal_sex_gland1.03126642
72MP0002282_abnormal_trachea_morphology1.03106457
73MP0004133_heterotaxia1.01811999
74MP0001145_abnormal_male_reproductive1.00905065
75MP0005248_abnormal_Harderian_gland1.00483491
76MP0002882_abnormal_neuron_morphology0.97558760
77MP0002822_catalepsy0.97439487
78MP0005645_abnormal_hypothalamus_physiol0.94834821
79MP0005670_abnormal_white_adipose0.92460306
80MP0004924_abnormal_behavior0.91869887
81MP0005386_behavior/neurological_phenoty0.91869887
82MP0003938_abnormal_ear_development0.91804169
83MP0004147_increased_porphyrin_level0.91350650
84MP0003633_abnormal_nervous_system0.91127802
85MP0000955_abnormal_spinal_cord0.90699005
86MP0002752_abnormal_somatic_nervous0.90676766
87MP0003122_maternal_imprinting0.89859124
88MP0005187_abnormal_penis_morphology0.87920685
89MP0000049_abnormal_middle_ear0.87038120
90MP0002102_abnormal_ear_morphology0.85805071
91MP0003137_abnormal_impulse_conducting0.85519289
92MP0008569_lethality_at_weaning0.83172421
93MP0003119_abnormal_digestive_system0.82520715
94MP0005195_abnormal_posterior_eye0.82271910
95MP0002184_abnormal_innervation0.80434726
96MP0002066_abnormal_motor_capabilities/c0.79980993
97MP0003879_abnormal_hair_cell0.79949861
98MP0000383_abnormal_hair_follicle0.79826848
99MP0005391_vision/eye_phenotype0.78862233
100MP0000681_abnormal_thyroid_gland0.76937369

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)5.01370422
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.96719422
3Absent/shortened dynein arms (HP:0200106)4.96719422
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.78062736
5Abnormal respiratory motile cilium physiology (HP:0012261)4.73419305
6Abnormal respiratory epithelium morphology (HP:0012253)4.62152335
7Abnormal respiratory motile cilium morphology (HP:0005938)4.62152335
8Retinal dysplasia (HP:0007973)4.54308833
9Rhinitis (HP:0012384)4.12607677
10Pancreatic fibrosis (HP:0100732)3.84438960
11Type II lissencephaly (HP:0007260)3.82418826
12True hermaphroditism (HP:0010459)3.74435158
13Molar tooth sign on MRI (HP:0002419)3.44032702
14Abnormality of midbrain morphology (HP:0002418)3.44032702
15Medial flaring of the eyebrow (HP:0010747)3.43701623
16Pancreatic cysts (HP:0001737)3.39133837
17Nephronophthisis (HP:0000090)3.30156721
18Gait imbalance (HP:0002141)3.25416828
19Progressive cerebellar ataxia (HP:0002073)3.24810014
20Chronic hepatic failure (HP:0100626)3.21567723
21Congenital stationary night blindness (HP:0007642)3.19804938
22Congenital primary aphakia (HP:0007707)3.04387046
23Attenuation of retinal blood vessels (HP:0007843)3.01670460
24Cerebellar dysplasia (HP:0007033)2.73906272
25Nephrogenic diabetes insipidus (HP:0009806)2.68921538
26Abnormality of the renal medulla (HP:0100957)2.68055706
27Bony spicule pigmentary retinopathy (HP:0007737)2.59437849
28Postaxial foot polydactyly (HP:0001830)2.59251313
29Cystic liver disease (HP:0006706)2.53816440
30Hemiparesis (HP:0001269)2.53276486
31Occipital encephalocele (HP:0002085)2.53090269
32Genital tract atresia (HP:0001827)2.47538444
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.41040172
34Sclerocornea (HP:0000647)2.40050969
35Focal motor seizures (HP:0011153)2.39063278
36Abnormal rod and cone electroretinograms (HP:0008323)2.37755538
37Vaginal atresia (HP:0000148)2.34500920
38Bronchiectasis (HP:0002110)2.32839687
39Large for gestational age (HP:0001520)2.26980232
40Abnormality of macular pigmentation (HP:0008002)2.26602970
41Gaze-evoked nystagmus (HP:0000640)2.24355132
42Tubulointerstitial nephritis (HP:0001970)2.23195676
43Poor coordination (HP:0002370)2.22784194
44Postaxial hand polydactyly (HP:0001162)2.21959753
45Male pseudohermaphroditism (HP:0000037)2.20353725
46Severe visual impairment (HP:0001141)2.18931057
47Hyperventilation (HP:0002883)2.15089056
48Renal dysplasia (HP:0000110)2.13031125
49Genetic anticipation (HP:0003743)2.11625793
50Lissencephaly (HP:0001339)2.09132193
51Abnormality of the aortic arch (HP:0012303)2.08739642
52Congenital hepatic fibrosis (HP:0002612)2.06729139
53Infertility (HP:0000789)2.05566173
54Broad-based gait (HP:0002136)2.02858927
55Increased corneal curvature (HP:0100692)2.02411747
56Keratoconus (HP:0000563)2.02411747
57Pachygyria (HP:0001302)2.00387421
58Polydipsia (HP:0001959)1.99907584
59Abnormal drinking behavior (HP:0030082)1.99907584
60Anencephaly (HP:0002323)1.97962069
61Abnormality of the renal cortex (HP:0011035)1.97693202
62Chronic bronchitis (HP:0004469)1.95520117
63Abnormality of the labia minora (HP:0012880)1.95491288
64Atonic seizures (HP:0010819)1.94224745
65Myokymia (HP:0002411)1.93019492
66Decreased central vision (HP:0007663)1.89627365
67Progressive microcephaly (HP:0000253)1.89554560
68Retinitis pigmentosa (HP:0000510)1.89341977
69Dyskinesia (HP:0100660)1.87477437
70Rib fusion (HP:0000902)1.83947935
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83165073
72Dysdiadochokinesis (HP:0002075)1.82917671
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80238989
74Abnormality of alanine metabolism (HP:0010916)1.80238989
75Hyperalaninemia (HP:0003348)1.80238989
76Polyphagia (HP:0002591)1.79952083
77Febrile seizures (HP:0002373)1.78067512
78Broad distal phalanx of finger (HP:0009836)1.75752668
79Aplasia/Hypoplasia of the lens (HP:0008063)1.72977860
80Preaxial hand polydactyly (HP:0001177)1.71985085
81Optic nerve hypoplasia (HP:0000609)1.71939081
82Specific learning disability (HP:0001328)1.70848197
83Epileptic encephalopathy (HP:0200134)1.70766327
84Abnormality of the fovea (HP:0000493)1.70682746
85Aganglionic megacolon (HP:0002251)1.68740311
86Furrowed tongue (HP:0000221)1.68152068
87Multicystic kidney dysplasia (HP:0000003)1.66627665
88Broad foot (HP:0001769)1.64459638
89Prominent nasal bridge (HP:0000426)1.64035386
90Focal seizures (HP:0007359)1.63717058
91Action tremor (HP:0002345)1.63514640
92Tubular atrophy (HP:0000092)1.63010386
93Congenital sensorineural hearing impairment (HP:0008527)1.62696605
94Abolished electroretinogram (ERG) (HP:0000550)1.62643122
95Hypoplastic ischia (HP:0003175)1.61832801
96Abnormality of the ischium (HP:0003174)1.61131221
97Abnormality of the diencephalon (HP:0010662)1.61015959
98Polyuria (HP:0000103)1.58913793
99Abnormal eating behavior (HP:0100738)1.58834088
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.56131628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.63594778
2FRK3.60859413
3PINK13.43337578
4INSRR3.12074693
5BMPR1B2.66240691
6MAPK152.59470912
7NTRK32.46789535
8ADRBK22.44134506
9WNK42.29502143
10PNCK2.17410046
11CASK2.13760962
12GRK12.10022528
13PLK42.07426620
14PRKD31.97774032
15BRSK21.75611898
16PHKG21.64172750
17PHKG11.64172750
18MARK11.62266915
19MAPK131.52461753
20FGFR21.52226028
21TESK11.48328628
22ZAK1.48063497
23DAPK21.38347816
24MAP3K41.38020145
25ACVR1B1.33220118
26EPHA41.31558351
27PLK21.28175549
28WNK31.27744365
29BCKDK1.23242560
30NME11.16544023
31TGFBR11.13243514
32LATS11.11448985
33UHMK11.11099991
34WEE11.06934157
35PKN11.06381309
36DYRK21.06165829
37STK38L1.02886545
38MAPKAPK51.02880754
39SGK4941.01274059
40SGK2231.01274059
41MAP3K20.96477270
42CSNK1G10.96410622
43PRKCG0.95907964
44CSNK1G20.94920419
45PTK2B0.94704389
46CDK190.92716713
47BRSK10.91469561
48CSNK1G30.90654834
49NTRK20.89035127
50CSNK1A1L0.88450101
51STK390.87696793
52TLK10.87610167
53WNK10.86263867
54NEK20.85490984
55TNK20.84025769
56EPHB20.81446507
57PRKCE0.81427639
58SIK20.78558722
59MAP2K70.76798284
60STK380.71272820
61CDK80.67870097
62CAMK2A0.67409926
63MAP3K90.64753746
64GRK50.64714947
65MINK10.58865933
66TAOK30.57034668
67OXSR10.56235273
68PAK30.56008644
69LIMK10.55213781
70VRK10.54670252
71CDK30.52770964
72CAMK1G0.50841266
73SGK10.50511019
74CDK50.49856447
75SGK20.49589716
76CAMK2B0.48564309
77PRKG10.47741784
78ADRBK10.47322878
79DDR20.47210388
80MST40.45570170
81CAMK2D0.44993566
82BCR0.43856562
83CSNK1A10.43218499
84RPS6KA50.42066117
85PLK10.41897615
86STK30.40464150
87ERBB20.38374011
88TRIM280.36702863
89TNIK0.36547838
90MAPKAPK30.35397856
91KSR20.35382213
92FER0.35259718
93MKNK20.34921014
94PRKACA0.34073509
95CAMK2G0.33528512
96MAP3K70.33084885
97PRKCH0.32451990
98CHEK20.32180284
99PAK60.30652387
100CAMKK20.30377657

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.53337476
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.97018329
3Nicotine addiction_Homo sapiens_hsa050332.65221981
4Butanoate metabolism_Homo sapiens_hsa006502.54874420
5Phototransduction_Homo sapiens_hsa047442.19600543
6Nitrogen metabolism_Homo sapiens_hsa009102.07507864
7Olfactory transduction_Homo sapiens_hsa047402.05327986
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01976297
9Taste transduction_Homo sapiens_hsa047421.84800202
10Morphine addiction_Homo sapiens_hsa050321.84508730
11GABAergic synapse_Homo sapiens_hsa047271.79232953
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77564618
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74339186
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72396399
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71365450
16Insulin secretion_Homo sapiens_hsa049111.68845290
17Circadian entrainment_Homo sapiens_hsa047131.54883776
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52333322
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.50399888
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48321972
21ABC transporters_Homo sapiens_hsa020101.48047468
22Glutamatergic synapse_Homo sapiens_hsa047241.46958661
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.46510260
24Selenocompound metabolism_Homo sapiens_hsa004501.45341913
25Oxidative phosphorylation_Homo sapiens_hsa001901.36904314
26Salivary secretion_Homo sapiens_hsa049701.31217122
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27285765
28Regulation of autophagy_Homo sapiens_hsa041401.26124327
29Folate biosynthesis_Homo sapiens_hsa007901.25551968
30Steroid biosynthesis_Homo sapiens_hsa001001.24852934
31Propanoate metabolism_Homo sapiens_hsa006401.22394365
32Huntingtons disease_Homo sapiens_hsa050161.21718629
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19453595
34Tryptophan metabolism_Homo sapiens_hsa003801.17480222
35Cocaine addiction_Homo sapiens_hsa050301.15368330
36Vitamin B6 metabolism_Homo sapiens_hsa007501.12448618
37Peroxisome_Homo sapiens_hsa041461.11694499
38Linoleic acid metabolism_Homo sapiens_hsa005911.11639694
39Amphetamine addiction_Homo sapiens_hsa050311.11337636
40Cardiac muscle contraction_Homo sapiens_hsa042601.10351583
41Synaptic vesicle cycle_Homo sapiens_hsa047211.10265425
42Circadian rhythm_Homo sapiens_hsa047101.09757178
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09060085
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08854793
45Calcium signaling pathway_Homo sapiens_hsa040201.06549900
46Serotonergic synapse_Homo sapiens_hsa047261.02767753
47Parkinsons disease_Homo sapiens_hsa050121.02221063
48beta-Alanine metabolism_Homo sapiens_hsa004101.01246521
49Homologous recombination_Homo sapiens_hsa034401.00873115
50Fanconi anemia pathway_Homo sapiens_hsa034601.00686593
51Retinol metabolism_Homo sapiens_hsa008301.00445634
52Chemical carcinogenesis_Homo sapiens_hsa052041.00233654
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99167282
54Dopaminergic synapse_Homo sapiens_hsa047280.98746835
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98651341
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94744068
57Histidine metabolism_Homo sapiens_hsa003400.94451254
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94087523
59Caffeine metabolism_Homo sapiens_hsa002320.93838998
60Gastric acid secretion_Homo sapiens_hsa049710.93100902
61Fatty acid biosynthesis_Homo sapiens_hsa000610.90139132
62Phenylalanine metabolism_Homo sapiens_hsa003600.87685114
63Basal transcription factors_Homo sapiens_hsa030220.83552171
64Sulfur relay system_Homo sapiens_hsa041220.83247870
65Dorso-ventral axis formation_Homo sapiens_hsa043200.82297903
66Collecting duct acid secretion_Homo sapiens_hsa049660.80577022
67Protein export_Homo sapiens_hsa030600.80365785
68Arginine and proline metabolism_Homo sapiens_hsa003300.78256356
69RNA polymerase_Homo sapiens_hsa030200.77872345
70Tyrosine metabolism_Homo sapiens_hsa003500.76894980
71Hedgehog signaling pathway_Homo sapiens_hsa043400.76001117
72Ether lipid metabolism_Homo sapiens_hsa005650.74821005
73Alzheimers disease_Homo sapiens_hsa050100.70568359
74Oocyte meiosis_Homo sapiens_hsa041140.69980035
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68661429
76Glycerolipid metabolism_Homo sapiens_hsa005610.68306602
77Fatty acid metabolism_Homo sapiens_hsa012120.66727973
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66658616
79Cholinergic synapse_Homo sapiens_hsa047250.66627123
80Purine metabolism_Homo sapiens_hsa002300.66235606
81Fatty acid degradation_Homo sapiens_hsa000710.65086684
82Metabolic pathways_Homo sapiens_hsa011000.64564405
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.64415882
84cAMP signaling pathway_Homo sapiens_hsa040240.64010291
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63780122
86Glutathione metabolism_Homo sapiens_hsa004800.61292046
87Renin secretion_Homo sapiens_hsa049240.58408589
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.58063655
89Mineral absorption_Homo sapiens_hsa049780.54445298
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54051152
91Pancreatic secretion_Homo sapiens_hsa049720.53714298
92Sphingolipid metabolism_Homo sapiens_hsa006000.52045515
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51934767
94Oxytocin signaling pathway_Homo sapiens_hsa049210.51070538
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50618235
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49387593
97Long-term depression_Homo sapiens_hsa047300.47590176
98Arachidonic acid metabolism_Homo sapiens_hsa005900.46167063
99Gap junction_Homo sapiens_hsa045400.46095086
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45865718

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