FAM180B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tachykinin receptor signaling pathway (GO:0007217)9.32988776
2positive regulation of digestive system process (GO:0060456)6.20344308
3L-fucose catabolic process (GO:0042355)5.18405691
4fucose catabolic process (GO:0019317)5.18405691
5L-fucose metabolic process (GO:0042354)5.18405691
6behavioral response to nicotine (GO:0035095)5.03741388
7detection of light stimulus involved in visual perception (GO:0050908)4.42682078
8detection of light stimulus involved in sensory perception (GO:0050962)4.42682078
9detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.36526955
10adaptation of signaling pathway (GO:0023058)4.27200163
11auditory receptor cell stereocilium organization (GO:0060088)3.90020243
12cochlea development (GO:0090102)3.89194933
13RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.77919359
14NAD biosynthetic process (GO:0009435)3.77450127
15regulation of germinal center formation (GO:0002634)3.72849650
16DNA deamination (GO:0045006)3.69425550
17gamma-aminobutyric acid signaling pathway (GO:0007214)3.68740733
18response to histamine (GO:0034776)3.53861090
19response to pheromone (GO:0019236)3.49830134
20DNA double-strand break processing (GO:0000729)3.46072427
21flavonoid metabolic process (GO:0009812)3.37574685
22negative regulation of mast cell activation (GO:0033004)3.29314654
23multicellular organism reproduction (GO:0032504)3.28472422
24positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.26475362
25sulfation (GO:0051923)3.19211286
26tryptophan catabolic process (GO:0006569)3.17430578
27indole-containing compound catabolic process (GO:0042436)3.17430578
28indolalkylamine catabolic process (GO:0046218)3.17430578
29aggressive behavior (GO:0002118)3.14921828
30detection of mechanical stimulus involved in sensory perception (GO:0050974)3.13442921
31mesenchymal cell differentiation involved in kidney development (GO:0072161)3.12350437
32mesenchymal cell differentiation involved in renal system development (GO:2001012)3.12350437
33reflex (GO:0060004)3.09099281
34negative regulation of systemic arterial blood pressure (GO:0003085)3.09070169
35adrenergic receptor signaling pathway (GO:0071875)3.09018598
36water-soluble vitamin biosynthetic process (GO:0042364)3.08573116
37inner ear receptor cell development (GO:0060119)3.05884154
38piRNA metabolic process (GO:0034587)3.05061402
39rRNA catabolic process (GO:0016075)3.01612995
40regulation of cilium movement (GO:0003352)3.01306393
41negative regulation of reactive oxygen species metabolic process (GO:2000378)3.00351384
42cell differentiation involved in metanephros development (GO:0072202)2.99447494
43pyridine nucleotide biosynthetic process (GO:0019363)2.98119710
44nicotinamide nucleotide biosynthetic process (GO:0019359)2.98119710
45regulation of action potential (GO:0098900)2.96137903
46kynurenine metabolic process (GO:0070189)2.95703841
47indolalkylamine metabolic process (GO:0006586)2.95514710
48inner ear receptor stereocilium organization (GO:0060122)2.94718291
49rhodopsin mediated signaling pathway (GO:0016056)2.88831180
50regulation of rhodopsin mediated signaling pathway (GO:0022400)2.88220640
51replication fork processing (GO:0031297)2.87181220
52innervation (GO:0060384)2.86276034
53L-methionine salvage (GO:0071267)2.82226618
54L-methionine biosynthetic process (GO:0071265)2.82226618
55amino acid salvage (GO:0043102)2.82226618
56tryptophan metabolic process (GO:0006568)2.80050083
57DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.78487752
58transepithelial transport (GO:0070633)2.78057008
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75020552
60regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.69695248
61gamma-aminobutyric acid transport (GO:0015812)2.66405361
62positive regulation of guanylate cyclase activity (GO:0031284)2.66254978
63phosphatidylinositol acyl-chain remodeling (GO:0036149)2.64502297
64postsynaptic membrane organization (GO:0001941)2.63379913
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61566805
66righting reflex (GO:0060013)2.61451020
67negative regulation of multicellular organism growth (GO:0040015)2.58626620
68double-strand break repair via homologous recombination (GO:0000724)2.58132043
69recombinational repair (GO:0000725)2.57099494
70synaptic transmission, cholinergic (GO:0007271)2.55558466
71regulation of timing of cell differentiation (GO:0048505)2.55029443
72behavioral response to ethanol (GO:0048149)2.53964605
73retinal cone cell development (GO:0046549)2.53960596
74protein polyglutamylation (GO:0018095)2.52018273
75sperm motility (GO:0030317)2.51066202
76negative regulation of astrocyte differentiation (GO:0048712)2.50444785
77cornea development in camera-type eye (GO:0061303)2.50403859
78negative regulation of smooth muscle cell differentiation (GO:0051151)2.49676133
79negative regulation by host of viral transcription (GO:0043922)2.48937035
80neural tube formation (GO:0001841)2.48384800
81positive regulation of glomerulus development (GO:0090193)2.47447480
82cAMP catabolic process (GO:0006198)2.47052062
83ADP metabolic process (GO:0046031)2.46422999
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44674989
85negative regulation of telomere maintenance (GO:0032205)2.44105951
86pseudouridine synthesis (GO:0001522)2.43395464
87negative regulation of transcription regulatory region DNA binding (GO:2000678)2.42969135
88photoreceptor cell maintenance (GO:0045494)2.42878597
89fucosylation (GO:0036065)2.42679529
90DNA damage response, signal transduction resulting in transcription (GO:0042772)2.39509389
91cellular response to exogenous dsRNA (GO:0071360)2.38121981
92DNA methylation involved in gamete generation (GO:0043046)2.38004431
93cellular ketone body metabolic process (GO:0046950)2.36681912
94protein K11-linked deubiquitination (GO:0035871)2.36020104
95indole-containing compound metabolic process (GO:0042430)2.35655000
96protein localization to cilium (GO:0061512)2.35633802
97proline transport (GO:0015824)2.35562540
98photoreceptor cell development (GO:0042461)2.34878307
99regulation of interferon-gamma biosynthetic process (GO:0045072)2.33253378
100regulation of digestive system process (GO:0044058)2.31798932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.64769527
2EZH2_22144423_ChIP-Seq_EOC_Human3.64025832
3ZNF274_21170338_ChIP-Seq_K562_Hela3.38827911
4GBX2_23144817_ChIP-Seq_PC3_Human3.20261329
5VDR_22108803_ChIP-Seq_LS180_Human3.12532564
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.06864735
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82110478
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.65332732
9IGF1R_20145208_ChIP-Seq_DFB_Human2.32120113
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31623032
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30685852
12BCAT_22108803_ChIP-Seq_LS180_Human2.26416866
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26173561
14TAF15_26573619_Chip-Seq_HEK293_Human2.18578052
15P300_19829295_ChIP-Seq_ESCs_Human2.16802981
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11827823
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00832682
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97046963
19FUS_26573619_Chip-Seq_HEK293_Human1.96852753
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88368647
21EWS_26573619_Chip-Seq_HEK293_Human1.84833946
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.83470355
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.79520849
24ER_23166858_ChIP-Seq_MCF-7_Human1.76781268
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73174458
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72424376
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71061956
28STAT3_23295773_ChIP-Seq_U87_Human1.68174352
29CBP_20019798_ChIP-Seq_JUKART_Human1.64036857
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64036857
31TCF4_23295773_ChIP-Seq_U87_Human1.62776608
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60573875
33SMAD4_21799915_ChIP-Seq_A2780_Human1.60242081
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55550154
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.54626279
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52786499
37TCF4_22108803_ChIP-Seq_LS180_Human1.51630199
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49211947
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47775073
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47239853
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47239853
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45685969
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44234877
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.43811793
45AR_25329375_ChIP-Seq_VCAP_Human1.42574239
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37293632
47TP53_22573176_ChIP-Seq_HFKS_Human1.36836918
48NANOG_19829295_ChIP-Seq_ESCs_Human1.36576212
49SOX2_19829295_ChIP-Seq_ESCs_Human1.36576212
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.33329092
51RNF2_27304074_Chip-Seq_NSC_Mouse1.31838461
52REST_21632747_ChIP-Seq_MESCs_Mouse1.30435030
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28090005
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.26670759
55RUNX2_22187159_ChIP-Seq_PCA_Human1.26307375
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24818710
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24575480
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23479805
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22831624
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.22267634
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21493378
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21403213
63IRF1_19129219_ChIP-ChIP_H3396_Human1.21165282
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.19996716
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19746336
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.18761427
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18522407
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.18487772
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16960407
70CDX2_22108803_ChIP-Seq_LS180_Human1.15778533
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15054513
72AR_21572438_ChIP-Seq_LNCaP_Human1.14647867
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.13629561
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13629561
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12681833
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11885258
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.11056156
78AR_20517297_ChIP-Seq_VCAP_Human1.10098414
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.09907786
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08005507
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06283883
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05966975
83OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05887545
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05465830
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04966281
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03793656
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03333172
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03056947
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.02234271
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01615041
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.01576209
92P53_22387025_ChIP-Seq_ESCs_Mouse1.01264327
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00508440
94HOXB7_26014856_ChIP-Seq_BT474_Human0.99795296
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99249594
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98824345
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.97893353
98KDM2B_26808549_Chip-Seq_REH_Human0.96302302
99NCOR_22424771_ChIP-Seq_293T_Human0.96151193
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95172670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.30160790
2MP0001501_abnormal_sleep_pattern3.27989401
3MP0000372_irregular_coat_pigmentation3.22552894
4MP0003646_muscle_fatigue3.03083906
5MP0005551_abnormal_eye_electrophysiolog2.88010344
6MP0001968_abnormal_touch/_nociception2.77412916
7MP0008872_abnormal_physiological_respon2.75068471
8MP0002736_abnormal_nociception_after2.56777464
9MP0002102_abnormal_ear_morphology2.41479619
10MP0000569_abnormal_digit_pigmentation2.38314417
11MP0002138_abnormal_hepatobiliary_system2.25775227
12MP0005645_abnormal_hypothalamus_physiol2.16986689
13MP0008877_abnormal_DNA_methylation2.11280234
14MP0005646_abnormal_pituitary_gland2.01035290
15MP0004043_abnormal_pH_regulation1.99375499
16MP0005253_abnormal_eye_physiology1.90564019
17MP0009745_abnormal_behavioral_response1.85543709
18MP0001986_abnormal_taste_sensitivity1.80475934
19MP0004742_abnormal_vestibular_system1.80087530
20MP0002735_abnormal_chemical_nociception1.78063819
21MP0002234_abnormal_pharynx_morphology1.75156820
22MP0006276_abnormal_autonomic_nervous1.74801839
23MP0001486_abnormal_startle_reflex1.71439386
24MP0010386_abnormal_urinary_bladder1.71412898
25MP0002272_abnormal_nervous_system1.67236630
26MP0002876_abnormal_thyroid_physiology1.63090016
27MP0004885_abnormal_endolymph1.60930222
28MP0009046_muscle_twitch1.60667535
29MP0004142_abnormal_muscle_tone1.56671589
30MP0006292_abnormal_olfactory_placode1.55008464
31MP0009697_abnormal_copulation1.44863941
32MP0000427_abnormal_hair_cycle1.42468383
33MP0008875_abnormal_xenobiotic_pharmacok1.41839352
34MP0003718_maternal_effect1.37454717
35MP0002733_abnormal_thermal_nociception1.36768638
36MP0006072_abnormal_retinal_apoptosis1.33818406
37MP0001485_abnormal_pinna_reflex1.33417866
38MP0001984_abnormal_olfaction1.31857476
39MP0002572_abnormal_emotion/affect_behav1.29537930
40MP0002638_abnormal_pupillary_reflex1.26543367
41MP0002184_abnormal_innervation1.23985984
42MP0001970_abnormal_pain_threshold1.22610067
43MP0003635_abnormal_synaptic_transmissio1.18640117
44MP0005084_abnormal_gallbladder_morpholo1.16911121
45MP0003880_abnormal_central_pattern1.16544537
46MP0005167_abnormal_blood-brain_barrier1.15931209
47MP0003136_yellow_coat_color1.14807217
48MP0004215_abnormal_myocardial_fiber1.14797020
49MP0005410_abnormal_fertilization1.13845815
50MP0005671_abnormal_response_to1.12323355
51MP0000631_abnormal_neuroendocrine_gland1.12313744
52MP0001440_abnormal_grooming_behavior1.12113715
53MP0008775_abnormal_heart_ventricle1.10666368
54MP0001963_abnormal_hearing_physiology1.08633599
55MP0004484_altered_response_of1.08351515
56MP0002751_abnormal_autonomic_nervous1.08132668
57MP0000383_abnormal_hair_follicle1.07798919
58MP0002067_abnormal_sensory_capabilities1.07614663
59MP0001324_abnormal_eye_pigmentation1.06809161
60MP0000026_abnormal_inner_ear1.06296680
61MP0004145_abnormal_muscle_electrophysio1.06244259
62MP0003943_abnormal_hepatobiliary_system1.04982705
63MP0005075_abnormal_melanosome_morpholog1.02008583
64MP0002653_abnormal_ependyma_morphology1.00465281
65MP0002837_dystrophic_cardiac_calcinosis0.98075941
66MP0001764_abnormal_homeostasis0.98056818
67MP0001835_abnormal_antigen_presentation0.97831500
68MP0000230_abnormal_systemic_arterial0.91828274
69MP0002064_seizures0.90983230
70MP0001905_abnormal_dopamine_level0.89897727
71MP0003950_abnormal_plasma_membrane0.89800049
72MP0002557_abnormal_social/conspecific_i0.88875991
73MP0002752_abnormal_somatic_nervous0.87102220
74MP0001873_stomach_inflammation0.87005432
75MP0005195_abnormal_posterior_eye0.85144414
76MP0008057_abnormal_DNA_replication0.84710848
77MP0003878_abnormal_ear_physiology0.84505451
78MP0005377_hearing/vestibular/ear_phenot0.84505451
79MP0002229_neurodegeneration0.84472118
80MP0005647_abnormal_sex_gland0.82428690
81MP0005395_other_phenotype0.82032059
82MP0002168_other_aberrant_phenotype0.81779472
83MP0003787_abnormal_imprinting0.79983980
84MP0000778_abnormal_nervous_system0.78356240
85MP0004084_abnormal_cardiac_muscle0.78154235
86MP0005423_abnormal_somatic_nervous0.77992521
87MP0002063_abnormal_learning/memory/cond0.75359514
88MP0002734_abnormal_mechanical_nocicepti0.74305386
89MP0003698_abnormal_male_reproductive0.74027514
90MP0005379_endocrine/exocrine_gland_phen0.73652302
91MP0005332_abnormal_amino_acid0.73166972
92MP0004085_abnormal_heartbeat0.72620672
93MP0005174_abnormal_tail_pigmentation0.71939597
94MP0005391_vision/eye_phenotype0.70975816
95MP0004924_abnormal_behavior0.70165180
96MP0005386_behavior/neurological_phenoty0.70165180
97MP0002163_abnormal_gland_morphology0.69761961
98MP0003252_abnormal_bile_duct0.69053035
99MP0010329_abnormal_lipoprotein_level0.68914339
100MP0002938_white_spotting0.68641079

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macular pigmentation (HP:0008002)4.58229541
2Decreased central vision (HP:0007663)4.48326938
3Attenuation of retinal blood vessels (HP:0007843)4.05701393
4Pancreatic cysts (HP:0001737)3.96487350
5Decreased electroretinogram (ERG) amplitude (HP:0000654)3.60416743
6True hermaphroditism (HP:0010459)3.59836432
7Nephronophthisis (HP:0000090)3.57859124
8Progressive inability to walk (HP:0002505)3.55775501
9Congenital stationary night blindness (HP:0007642)3.49820531
10Abnormality of midbrain morphology (HP:0002418)3.38009870
11Molar tooth sign on MRI (HP:0002419)3.38009870
12Pancreatic fibrosis (HP:0100732)3.25417870
13Abolished electroretinogram (ERG) (HP:0000550)3.23844141
14Abnormality of the renal medulla (HP:0100957)3.12540960
15Abnormality of the renal cortex (HP:0011035)3.05587431
16Chorioretinal atrophy (HP:0000533)3.04262043
17Macular degeneration (HP:0000608)2.86557700
18Inability to walk (HP:0002540)2.82041292
19Decreased circulating renin level (HP:0003351)2.74898186
20Dyschromatopsia (HP:0007641)2.62904907
21Abnormal drinking behavior (HP:0030082)2.59984485
22Polydipsia (HP:0001959)2.59984485
23Increased corneal curvature (HP:0100692)2.58627684
24Keratoconus (HP:0000563)2.58627684
25Type II lissencephaly (HP:0007260)2.56440053
26Pendular nystagmus (HP:0012043)2.56416115
27Medial flaring of the eyebrow (HP:0010747)2.55304400
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54544966
29Abnormality of alanine metabolism (HP:0010916)2.54544966
30Hyperalaninemia (HP:0003348)2.54544966
31Aplasia/Hypoplasia of the fovea (HP:0008060)2.53582390
32Hypoplasia of the fovea (HP:0007750)2.53582390
33Gaze-evoked nystagmus (HP:0000640)2.43178226
34Chronic hepatic failure (HP:0100626)2.40427419
35IgG deficiency (HP:0004315)2.39121734
36Progressive cerebellar ataxia (HP:0002073)2.36902886
37Stomach cancer (HP:0012126)2.36781952
38Hyperventilation (HP:0002883)2.36292544
39Type 2 muscle fiber atrophy (HP:0003554)2.32123512
40Renal cortical cysts (HP:0000803)2.29221533
41Abnormal rod and cone electroretinograms (HP:0008323)2.29127736
42Poikiloderma (HP:0001029)2.27985472
43Cystic liver disease (HP:0006706)2.27414190
44Abnormality of the fovea (HP:0000493)2.26831090
45Constricted visual fields (HP:0001133)2.26116577
46Febrile seizures (HP:0002373)2.25700460
47Polyuria (HP:0000103)2.22096634
48Prostate neoplasm (HP:0100787)2.20215035
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.19792829
50Tubular atrophy (HP:0000092)2.16772367
51Fibular aplasia (HP:0002990)2.15413362
52Bony spicule pigmentary retinopathy (HP:0007737)2.12532338
53Methylmalonic acidemia (HP:0002912)2.06458386
54Congenital hepatic fibrosis (HP:0002612)2.04792202
55Sclerocornea (HP:0000647)2.04765307
56Hypophosphatemic rickets (HP:0004912)2.04762500
57Thyroiditis (HP:0100646)2.04687397
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00881543
59Aplasia/Hypoplasia of the tibia (HP:0005772)1.99929815
60Absent/shortened dynein arms (HP:0200106)1.98190021
61Dynein arm defect of respiratory motile cilia (HP:0012255)1.98190021
62Genetic anticipation (HP:0003743)1.97240890
63Abnormal delayed hypersensitivity skin test (HP:0002963)1.96411947
64Abnormality of the labia minora (HP:0012880)1.94378688
65Cerebellar dysplasia (HP:0007033)1.94194249
66Disproportionate short-trunk short stature (HP:0003521)1.91709079
67Absent speech (HP:0001344)1.90758736
68Genital tract atresia (HP:0001827)1.90054423
69Vaginal atresia (HP:0000148)1.89069347
70Small hand (HP:0200055)1.89066997
71Gait imbalance (HP:0002141)1.88536885
72Lissencephaly (HP:0001339)1.88028513
73Nephrogenic diabetes insipidus (HP:0009806)1.86503655
74Broad-based gait (HP:0002136)1.85908563
75Congenital primary aphakia (HP:0007707)1.85879021
76Concave nail (HP:0001598)1.85392287
77Hypomagnesemia (HP:0002917)1.85091185
78Fair hair (HP:0002286)1.84751854
79Facial shape deformation (HP:0011334)1.82608428
80Potter facies (HP:0002009)1.82608428
81Widely spaced teeth (HP:0000687)1.81743563
82Abnormality of B cell number (HP:0010975)1.78863111
83Ketosis (HP:0001946)1.78752834
84Partial agenesis of the corpus callosum (HP:0001338)1.77498865
85Abnormality of the prostate (HP:0008775)1.77024651
86Methylmalonic aciduria (HP:0012120)1.76162716
87Anhidrosis (HP:0000970)1.76109044
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75373254
89Hyperglycinuria (HP:0003108)1.75079317
90Abnormal urine output (HP:0012590)1.74837788
91Focal motor seizures (HP:0011153)1.74317270
92Severe muscular hypotonia (HP:0006829)1.74160117
93Focal seizures (HP:0007359)1.72843068
94Tubulointerstitial abnormality (HP:0001969)1.72746493
95Postaxial foot polydactyly (HP:0001830)1.72556318
96Stomatitis (HP:0010280)1.72451033
97Aplasia/hypoplasia of the uterus (HP:0008684)1.72039916
98Pachygyria (HP:0001302)1.70893539
99Hypokalemic alkalosis (HP:0001949)1.70592990
100Tubulointerstitial nephritis (HP:0001970)1.69900863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.36668841
2MAP4K24.16132966
3ZAK2.92561991
4ADRBK22.82050345
5PINK12.71006165
6BMPR1B2.62744282
7NUAK12.42574202
8WNK32.17158972
9GRK12.12285586
10MAP3K42.01173405
11TAOK31.99326814
12NEK61.93748396
13TRIM281.92390685
14MAPK131.91401130
15KIT1.61334643
16TLK11.59143074
17WNK41.51356750
18INSRR1.46264483
19TNIK1.42965857
20TIE11.40165740
21TAF11.39643043
22CSNK1A1L1.36189820
23TXK1.31400240
24STK391.30489289
25ACVR1B1.29240080
26MAP2K71.28378009
27BRSK21.14628686
28OXSR11.13888261
29NEK11.13208855
30PRKCE1.07535531
31BCR1.03300114
32CSNK1G21.02043616
33NEK20.98985837
34DAPK20.98307906
35VRK20.96948782
36PDK20.96075194
37PLK20.94425816
38PLK40.90806063
39ADRBK10.90783710
40TEC0.90587758
41MKNK20.90433051
42SIK20.89232462
43PAK30.88662373
44ERBB30.86808517
45EIF2AK30.84503008
46MATK0.82987280
47VRK10.82308005
48PHKG20.82303297
49PHKG10.82303297
50TGFBR10.81325423
51CSNK1G30.81302907
52CSNK1G10.78439250
53STK38L0.77941295
54CAMKK20.76875442
55CASK0.73450448
56AKT30.72824606
57DYRK20.71231352
58SRPK10.71076043
59PKN10.70954047
60ICK0.70870765
61SIK30.69641209
62PRKCG0.66156772
63WNK10.66152102
64IKBKB0.64698665
65TNK20.64574090
66MAPKAPK50.61763216
67MUSK0.60217512
68WEE10.60105300
69EPHA40.59801260
70MARK10.58735507
71PIK3CG0.58717685
72MAP2K60.58063808
73PRKAA20.57091022
74FES0.57032518
75FER0.54517361
76PIK3CA0.54409862
77PTK2B0.52776464
78BRD40.52484081
79MAPKAPK30.49701008
80PLK30.46232363
81MARK30.45754040
82BUB10.45611833
83CAMK40.45377539
84PRKCQ0.43873359
85SYK0.43850710
86CAMK10.43228567
87BCKDK0.42436224
88NLK0.42114786
89OBSCN0.41651637
90IRAK10.41201172
91EIF2AK20.40692511
92CSNK1A10.39446960
93STK110.38360106
94PRKCA0.37992706
95CAMK2A0.37853458
96RPS6KA50.36852994
97CSNK1D0.36680105
98ATM0.36107780
99NTRK30.35250906
100MST40.35091598

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.34431662
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.69242271
3Asthma_Homo sapiens_hsa053102.65050924
4Phototransduction_Homo sapiens_hsa047442.64071432
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31160040
6Linoleic acid metabolism_Homo sapiens_hsa005912.29582698
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.18288139
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12591972
9Morphine addiction_Homo sapiens_hsa050322.10349036
10Nitrogen metabolism_Homo sapiens_hsa009101.94067800
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88732158
12Olfactory transduction_Homo sapiens_hsa047401.87379795
13Ether lipid metabolism_Homo sapiens_hsa005651.80652357
14Primary immunodeficiency_Homo sapiens_hsa053401.68039406
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66752471
16Butanoate metabolism_Homo sapiens_hsa006501.66424731
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64422294
18Caffeine metabolism_Homo sapiens_hsa002321.62854017
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62790074
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61236984
21GABAergic synapse_Homo sapiens_hsa047271.60916505
22Allograft rejection_Homo sapiens_hsa053301.58153814
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56391687
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.53402518
25Tryptophan metabolism_Homo sapiens_hsa003801.52294533
26RNA degradation_Homo sapiens_hsa030181.49504582
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47152026
28Arachidonic acid metabolism_Homo sapiens_hsa005901.46741645
29Autoimmune thyroid disease_Homo sapiens_hsa053201.44163806
30Taste transduction_Homo sapiens_hsa047421.40653148
31Glycerolipid metabolism_Homo sapiens_hsa005611.40166808
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39334841
33Homologous recombination_Homo sapiens_hsa034401.38469984
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35778474
35Salivary secretion_Homo sapiens_hsa049701.34947283
36Graft-versus-host disease_Homo sapiens_hsa053321.34805052
37Serotonergic synapse_Homo sapiens_hsa047261.32138985
38Type I diabetes mellitus_Homo sapiens_hsa049401.30846657
39Propanoate metabolism_Homo sapiens_hsa006401.27423645
40Chemical carcinogenesis_Homo sapiens_hsa052041.23273482
41Fanconi anemia pathway_Homo sapiens_hsa034601.21340143
42Basal transcription factors_Homo sapiens_hsa030221.20176183
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18331094
44Retinol metabolism_Homo sapiens_hsa008301.16981427
45Regulation of autophagy_Homo sapiens_hsa041401.16219090
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06786698
47Circadian entrainment_Homo sapiens_hsa047131.06132474
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.05084448
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.02843782
50ABC transporters_Homo sapiens_hsa020101.01554176
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97306512
52Ovarian steroidogenesis_Homo sapiens_hsa049130.96486237
53RNA polymerase_Homo sapiens_hsa030200.95359522
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89720266
55Insulin secretion_Homo sapiens_hsa049110.89276141
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.89009143
57Calcium signaling pathway_Homo sapiens_hsa040200.88325380
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87004275
59Non-homologous end-joining_Homo sapiens_hsa034500.82802898
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82626489
61Glutamatergic synapse_Homo sapiens_hsa047240.81985686
62beta-Alanine metabolism_Homo sapiens_hsa004100.74466558
63Histidine metabolism_Homo sapiens_hsa003400.74377726
64Fat digestion and absorption_Homo sapiens_hsa049750.71502875
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68790460
66Peroxisome_Homo sapiens_hsa041460.67219907
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66930255
68One carbon pool by folate_Homo sapiens_hsa006700.65466300
69Gastric acid secretion_Homo sapiens_hsa049710.62838313
70Dopaminergic synapse_Homo sapiens_hsa047280.62106852
71Antigen processing and presentation_Homo sapiens_hsa046120.61907344
72Rheumatoid arthritis_Homo sapiens_hsa053230.61673486
73Amphetamine addiction_Homo sapiens_hsa050310.58410481
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57071899
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56864141
76Dorso-ventral axis formation_Homo sapiens_hsa043200.56617515
77Renin secretion_Homo sapiens_hsa049240.56543304
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53311658
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.50630120
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.48966869
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.47694000
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.47534956
83Selenocompound metabolism_Homo sapiens_hsa004500.46325766
84Purine metabolism_Homo sapiens_hsa002300.46135234
85Thyroid hormone synthesis_Homo sapiens_hsa049180.45367905
86Protein export_Homo sapiens_hsa030600.43574318
87Cocaine addiction_Homo sapiens_hsa050300.41501960
88Collecting duct acid secretion_Homo sapiens_hsa049660.40948981
89Glutathione metabolism_Homo sapiens_hsa004800.40782065
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40277261
91Staphylococcus aureus infection_Homo sapiens_hsa051500.38447436
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37779304
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36663063
94Metabolic pathways_Homo sapiens_hsa011000.35086852
95Arginine and proline metabolism_Homo sapiens_hsa003300.34395038
96Circadian rhythm_Homo sapiens_hsa047100.33916029
97Long-term depression_Homo sapiens_hsa047300.33122518
98Oxytocin signaling pathway_Homo sapiens_hsa049210.33061894
99Oxidative phosphorylation_Homo sapiens_hsa001900.32226296
100Cholinergic synapse_Homo sapiens_hsa047250.31961257

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