FAM179B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.29216705
2cilium movement (GO:0003341)5.25222114
3axonemal dynein complex assembly (GO:0070286)4.71384767
4nuclear pore organization (GO:0006999)4.65844124
5mitotic sister chromatid cohesion (GO:0007064)4.52815358
6monoubiquitinated protein deubiquitination (GO:0035520)4.34786777
7axoneme assembly (GO:0035082)4.13769690
8negative regulation of hormone biosynthetic process (GO:0032353)4.05008774
9negative regulation of hormone metabolic process (GO:0032351)4.05008774
10intraciliary transport (GO:0042073)3.98600393
11interkinetic nuclear migration (GO:0022027)3.92151719
12pore complex assembly (GO:0046931)3.86823352
13cytoplasmic mRNA processing body assembly (GO:0033962)3.70761230
14cilium organization (GO:0044782)3.61424348
15negative regulation of cytosolic calcium ion concentration (GO:0051481)3.58746016
16cilium assembly (GO:0042384)3.56004093
17regulation of RNA export from nucleus (GO:0046831)3.50276450
18sister chromatid cohesion (GO:0007062)3.44708030
19regulation of nucleobase-containing compound transport (GO:0032239)3.33773573
20regulation of cilium movement (GO:0003352)3.28803094
21ventricular system development (GO:0021591)3.28206087
22protein localization to cilium (GO:0061512)3.26691862
23regulation of mitotic spindle organization (GO:0060236)3.26347797
24cilium or flagellum-dependent cell motility (GO:0001539)3.24036184
25cilium morphogenesis (GO:0060271)3.20089699
26photoreceptor cell maintenance (GO:0045494)3.18754975
27presynaptic membrane assembly (GO:0097105)3.17332671
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16277735
29protein targeting to Golgi (GO:0000042)3.15304767
30piRNA metabolic process (GO:0034587)3.15240229
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12345581
32male meiosis (GO:0007140)3.09058772
33nonmotile primary cilium assembly (GO:0035058)3.08969536
34cellular component assembly involved in morphogenesis (GO:0010927)3.08274567
35nucleus localization (GO:0051647)3.07961373
36retinal cone cell development (GO:0046549)3.07937501
37positive regulation of mitotic sister chromatid separation (GO:1901970)3.07913319
38positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.07913319
39positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.07913319
40regulation of spindle organization (GO:0090224)3.06982040
41glucocorticoid receptor signaling pathway (GO:0042921)3.01090615
42gamma-aminobutyric acid transport (GO:0015812)2.99847248
43corticosteroid receptor signaling pathway (GO:0031958)2.99620296
44establishment of protein localization to Golgi (GO:0072600)2.99610032
45presynaptic membrane organization (GO:0097090)2.96498036
46mitotic metaphase plate congression (GO:0007080)2.95674132
47acrosome assembly (GO:0001675)2.93108214
48brain morphogenesis (GO:0048854)2.92478795
49motile cilium assembly (GO:0044458)2.92460970
50regulation of sister chromatid cohesion (GO:0007063)2.91016586
51protein polyglutamylation (GO:0018095)2.87889314
52neural tube formation (GO:0001841)2.87506473
53regulation of telomere maintenance via telomerase (GO:0032210)2.87057788
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86456854
55negative regulation of translation, ncRNA-mediated (GO:0040033)2.86456854
56regulation of translation, ncRNA-mediated (GO:0045974)2.86456854
57regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84765017
58pre-miRNA processing (GO:0031054)2.84721898
59microtubule anchoring (GO:0034453)2.81415837
60histone lysine demethylation (GO:0070076)2.81175276
61negative regulation of histone methylation (GO:0031061)2.80095623
62histone phosphorylation (GO:0016572)2.79955365
63regulation of protein polyubiquitination (GO:1902914)2.78971662
64C4-dicarboxylate transport (GO:0015740)2.78502384
65regulation of establishment of cell polarity (GO:2000114)2.78497795
66retrograde transport, vesicle recycling within Golgi (GO:0000301)2.77623863
67regulation of telomere maintenance (GO:0032204)2.77228368
68limb development (GO:0060173)2.76902671
69appendage development (GO:0048736)2.76902671
70positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.75070732
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73524189
72regulation of meiosis I (GO:0060631)2.73223023
73histone H3-K9 demethylation (GO:0033169)2.73017165
74transmission of nerve impulse (GO:0019226)2.72646780
75histone H2A monoubiquitination (GO:0035518)2.72284975
76membrane depolarization during action potential (GO:0086010)2.71479870
77response to pheromone (GO:0019236)2.68141200
78central nervous system neuron axonogenesis (GO:0021955)2.67975755
79left/right axis specification (GO:0070986)2.67157163
80gene silencing by RNA (GO:0031047)2.65623609
81mitotic chromosome condensation (GO:0007076)2.65079987
82positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.63400441
83regulation of centriole replication (GO:0046599)2.63078892
84behavioral response to nicotine (GO:0035095)2.62158395
85histone demethylation (GO:0016577)2.61728045
86neuron cell-cell adhesion (GO:0007158)2.61463992
87regulation of pigment cell differentiation (GO:0050932)2.60255566
88regulation of ARF protein signal transduction (GO:0032012)2.58490936
89synaptonemal complex organization (GO:0070193)2.58191332
90synaptonemal complex assembly (GO:0007130)2.57792505
91DNA damage induced protein phosphorylation (GO:0006975)2.57450043
92regulation of glucocorticoid metabolic process (GO:0031943)2.54988529
93regulation of histone H3-K9 methylation (GO:0051570)2.54506537
94neuronal action potential (GO:0019228)2.54257603
95regulation of steroid hormone biosynthetic process (GO:0090030)2.54166377
96regulation of clathrin-mediated endocytosis (GO:2000369)2.53674810
97protein dealkylation (GO:0008214)2.53517942
98protein demethylation (GO:0006482)2.53517942
99metaphase plate congression (GO:0051310)2.53132793
100central nervous system projection neuron axonogenesis (GO:0021952)2.51553118
101ionotropic glutamate receptor signaling pathway (GO:0035235)2.51113287
102limb bud formation (GO:0060174)2.50355252
103protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.49380712
104NLS-bearing protein import into nucleus (GO:0006607)2.48989479
105protein K11-linked deubiquitination (GO:0035871)2.48682980
106neurotransmitter-gated ion channel clustering (GO:0072578)2.48654667
107regulation of DNA endoreduplication (GO:0032875)2.48607128
108postsynaptic membrane organization (GO:0001941)2.47479265
109behavioral response to ethanol (GO:0048149)2.47439038
110microtubule bundle formation (GO:0001578)2.47045858
111epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.46935578
112detection of light stimulus involved in sensory perception (GO:0050962)2.44975705
113detection of light stimulus involved in visual perception (GO:0050908)2.44975705
114cellular ketone body metabolic process (GO:0046950)2.44747318
115smoothened signaling pathway (GO:0007224)2.44512140
116sister chromatid segregation (GO:0000819)2.44356926
117glutamate receptor signaling pathway (GO:0007215)2.44351025
118reflex (GO:0060004)2.44190257
119embryonic body morphogenesis (GO:0010172)2.43529659
120neuronal action potential propagation (GO:0019227)2.42413353
121positive regulation of meiosis (GO:0045836)2.42321038
122regulation of establishment or maintenance of cell polarity (GO:0032878)2.42027235
123regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.41781600
124regulation of hormone biosynthetic process (GO:0046885)2.41334201
125phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.41261459
126sperm motility (GO:0030317)2.41254737
127replicative senescence (GO:0090399)2.40251346
128negative regulation of circadian rhythm (GO:0042754)2.40015268
129axon ensheathment in central nervous system (GO:0032291)2.39938436
130central nervous system myelination (GO:0022010)2.39938436
131startle response (GO:0001964)2.39497276
132inner ear receptor stereocilium organization (GO:0060122)2.39345735
133male meiosis I (GO:0007141)2.39262255
134artery development (GO:0060840)2.38965669
135meiotic cell cycle (GO:0051321)2.38890265
136regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.38329610
137axonal fasciculation (GO:0007413)2.37941835
138synaptic vesicle maturation (GO:0016188)2.36856224
139retinal rod cell development (GO:0046548)2.36503970
140left/right pattern formation (GO:0060972)2.36292832
141fusion of sperm to egg plasma membrane (GO:0007342)2.35935350
142protein localization to chromosome, centromeric region (GO:0071459)2.35857412
143regulation of cell communication by electrical coupling (GO:0010649)2.35363971
144establishment of nucleus localization (GO:0040023)2.34706317
145proline transport (GO:0015824)2.34432575
146regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.34054531
147membrane disassembly (GO:0030397)2.33811444
148nuclear envelope disassembly (GO:0051081)2.33811444
149regulation of transforming growth factor beta2 production (GO:0032909)2.32925784
150peptidyl-threonine phosphorylation (GO:0018107)2.32512730
151synaptic vesicle exocytosis (GO:0016079)2.32474778
152negative regulation of inclusion body assembly (GO:0090084)2.31602284
153negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.30854617
154auditory behavior (GO:0031223)2.30607498
155mitotic nuclear envelope disassembly (GO:0007077)2.30561815
156dendritic spine morphogenesis (GO:0060997)2.29547950
157negative regulation of neurotransmitter transport (GO:0051589)2.29109572
158vesicle transport along microtubule (GO:0047496)2.28764486
159serotonin metabolic process (GO:0042428)2.28534090
160otic vesicle formation (GO:0030916)2.28140974
161cell projection assembly (GO:0030031)2.27543357
162N-terminal protein amino acid acetylation (GO:0006474)2.27395169
163regulation of protein glycosylation (GO:0060049)2.26689806
164regulation of synaptic vesicle exocytosis (GO:2000300)2.26483138
165synaptic transmission, glutamatergic (GO:0035249)2.25599817
166positive regulation of chromosome segregation (GO:0051984)2.24973728
167retina layer formation (GO:0010842)2.24875223
168photoreceptor cell development (GO:0042461)2.24683913
169regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.24633764
170stress granule assembly (GO:0034063)2.24630309
171retinal ganglion cell axon guidance (GO:0031290)2.24343835
172glutamate secretion (GO:0014047)2.24306063
173auditory receptor cell stereocilium organization (GO:0060088)2.24032035
174determination of left/right symmetry (GO:0007368)2.24013207
175meiotic chromosome segregation (GO:0045132)2.23821623
176negative regulation of DNA repair (GO:0045738)2.23563722
177establishment of chromosome localization (GO:0051303)2.23190235
178protein localization to Golgi apparatus (GO:0034067)2.23059960
179Golgi to endosome transport (GO:0006895)2.23026489
180negative regulation of telomere maintenance (GO:0032205)2.23004650
181synaptic vesicle docking involved in exocytosis (GO:0016081)2.22201601
182peptidyl-threonine modification (GO:0018210)2.21930496
183detection of mechanical stimulus involved in sensory perception (GO:0050974)2.21799014
184cerebellar Purkinje cell differentiation (GO:0021702)2.21660623
185regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.21448898
186positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.21001704
187regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.21001704
188phosphorelay signal transduction system (GO:0000160)2.19590812
189spermatid development (GO:0007286)2.19212227
190epithelial cilium movement (GO:0003351)2.18705015
191mitotic sister chromatid segregation (GO:0000070)2.18006257
192sodium ion export (GO:0071436)2.17832204
193type B pancreatic cell development (GO:0003323)2.17756696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human4.04821477
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.40729338
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.34847240
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08258951
5E2F7_22180533_ChIP-Seq_HELA_Human3.02015791
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.76842119
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.66172378
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46874678
9IGF1R_20145208_ChIP-Seq_DFB_Human2.44098597
10VDR_22108803_ChIP-Seq_LS180_Human2.38170160
11GBX2_23144817_ChIP-Seq_PC3_Human2.37452143
12* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.35252489
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30842627
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23533609
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14036713
16EZH2_22144423_ChIP-Seq_EOC_Human2.11149095
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09675065
18FUS_26573619_Chip-Seq_HEK293_Human2.08502564
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03091474
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.00024531
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89013756
22SMAD4_21799915_ChIP-Seq_A2780_Human1.78444068
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.77608960
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77242090
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.74647962
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74087261
27STAT3_23295773_ChIP-Seq_U87_Human1.70853869
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70756457
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.64707318
30* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.63728750
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59980947
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.55902497
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55295881
34TAF15_26573619_Chip-Seq_HEK293_Human1.54734642
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50668481
36CBP_20019798_ChIP-Seq_JUKART_Human1.49927382
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49927382
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49769402
39TCF4_23295773_ChIP-Seq_U87_Human1.47204093
40AR_21572438_ChIP-Seq_LNCaP_Human1.46344798
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.46101363
42FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41919904
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41693233
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40784662
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39761364
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.38885010
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36651334
48TCF4_22108803_ChIP-Seq_LS180_Human1.34736989
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34452806
50AHR_22903824_ChIP-Seq_MCF-7_Human1.33561449
51EWS_26573619_Chip-Seq_HEK293_Human1.32041759
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.30935368
53TP53_16413492_ChIP-PET_HCT116_Human1.30775093
54BCAT_22108803_ChIP-Seq_LS180_Human1.25928390
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25769810
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25769810
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25576622
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25121538
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24850583
60P300_19829295_ChIP-Seq_ESCs_Human1.24626557
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24591279
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24150822
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.23344355
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22761801
65TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.22334916
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20844677
67AR_25329375_ChIP-Seq_VCAP_Human1.20415632
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20345674
69YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20274353
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20124725
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19844158
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18021499
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17588846
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16953546
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16694852
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15828232
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.15382837
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.15126753
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.15118879
80ZNF274_21170338_ChIP-Seq_K562_Hela1.13934487
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.13822461
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13155805
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13137082
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.12614018
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.11925233
86AR_19668381_ChIP-Seq_PC3_Human1.10280794
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09976284
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09976284
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.08230436
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.06768095
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06686829
92DROSHA_22980978_ChIP-Seq_HELA_Human1.06553548
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06429665
94BRD4_25478319_ChIP-Seq_HGPS_Human1.05790697
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.05720976
96REST_21632747_ChIP-Seq_MESCs_Mouse1.05432325
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05337570
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.05098349
99NANOG_19829295_ChIP-Seq_ESCs_Human1.04650781
100SOX2_19829295_ChIP-Seq_ESCs_Human1.04650781
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04185483
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04059017
103* CDX2_22108803_ChIP-Seq_LS180_Human1.04041731
104TP53_18474530_ChIP-ChIP_U2OS_Human1.03485860
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03455304
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03033593
107ESR1_20079471_ChIP-ChIP_T-47D_Human1.02924565
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02758044
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02360111
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02195191
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01656888
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01622982
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01539257
114TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00529424
115AR_21909140_ChIP-Seq_LNCAP_Human1.00501859
116TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00169756
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99889923
118SOX9_26525672_Chip-Seq_HEART_Mouse0.97649488
119ER_23166858_ChIP-Seq_MCF-7_Human0.96895442
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96856016
121E2F1_21310950_ChIP-Seq_MCF-7_Human0.96620608
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96580956
123CMYC_18555785_Chip-Seq_ESCs_Mouse0.96202066
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95477108
125RNF2_27304074_Chip-Seq_NSC_Mouse0.95062332
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94858673
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94649869
128RUNX2_22187159_ChIP-Seq_PCA_Human0.93480223
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.93292927
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92079369
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92060144
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.91766996
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.90917583
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.90108375
135P53_22387025_ChIP-Seq_ESCs_Mouse0.89903495
136TBL1_22424771_ChIP-Seq_293T_Human0.89541013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.86904577
2MP0000569_abnormal_digit_pigmentation3.41351916
3MP0003880_abnormal_central_pattern3.27013822
4MP0003787_abnormal_imprinting3.17338943
5MP0004859_abnormal_synaptic_plasticity2.84848952
6MP0005410_abnormal_fertilization2.68007587
7MP0010234_abnormal_vibrissa_follicle2.67520356
8MP0002877_abnormal_melanocyte_morpholog2.36820623
9MP0006276_abnormal_autonomic_nervous2.25132015
10MP0009780_abnormal_chondrocyte_physiolo2.21983161
11MP0001486_abnormal_startle_reflex2.10298908
12MP0010307_abnormal_tumor_latency2.08907658
13MP0003121_genomic_imprinting2.08299535
14MP0003123_paternal_imprinting2.02981938
15MP0004270_analgesia1.96288108
16MP0002822_catalepsy1.92317283
17MP0002102_abnormal_ear_morphology1.89446760
18MP0001929_abnormal_gametogenesis1.86155278
19MP0002272_abnormal_nervous_system1.84906626
20MP0010094_abnormal_chromosome_stability1.84634762
21MP0002735_abnormal_chemical_nociception1.83928420
22MP0003111_abnormal_nucleus_morphology1.80513799
23MP0000383_abnormal_hair_follicle1.80425914
24MP0008057_abnormal_DNA_replication1.80267055
25MP0000427_abnormal_hair_cycle1.79610721
26MP0003890_abnormal_embryonic-extraembry1.78101032
27MP0001986_abnormal_taste_sensitivity1.75540032
28MP0002638_abnormal_pupillary_reflex1.75459058
29MP0005076_abnormal_cell_differentiation1.72967699
30MP0005253_abnormal_eye_physiology1.71960166
31MP0004145_abnormal_muscle_electrophysio1.69810456
32MP0002064_seizures1.68294686
33MP0005423_abnormal_somatic_nervous1.68112687
34MP0002009_preneoplasia1.67744140
35MP0003045_fibrosis1.64102359
36MP0004133_heterotaxia1.63994523
37MP0000778_abnormal_nervous_system1.63037978
38MP0004264_abnormal_extraembryonic_tissu1.60148451
39MP0003698_abnormal_male_reproductive1.57709914
40MP0002837_dystrophic_cardiac_calcinosis1.56276567
41MP0001501_abnormal_sleep_pattern1.55755386
42MP0003635_abnormal_synaptic_transmissio1.55509518
43MP0002084_abnormal_developmental_patter1.51514549
44MP0004885_abnormal_endolymph1.49248382
45MP0002736_abnormal_nociception_after1.47027591
46MP0001485_abnormal_pinna_reflex1.45275135
47MP0004215_abnormal_myocardial_fiber1.40350595
48MP0004043_abnormal_pH_regulation1.39859759
49MP0003195_calcinosis1.39392236
50MP0003077_abnormal_cell_cycle1.36956546
51MP0010352_gastrointestinal_tract_polyps1.35300656
52MP0005623_abnormal_meninges_morphology1.35220319
53MP0002557_abnormal_social/conspecific_i1.34985175
54MP0001730_embryonic_growth_arrest1.34922947
55MP0005187_abnormal_penis_morphology1.34044869
56MP0003300_gastrointestinal_ulcer1.32388410
57MP0008961_abnormal_basal_metabolism1.31634674
58MP0002210_abnormal_sex_determination1.31108758
59MP0002063_abnormal_learning/memory/cond1.30401055
60MP0000372_irregular_coat_pigmentation1.29393898
61MP0010386_abnormal_urinary_bladder1.28113718
62MP0008775_abnormal_heart_ventricle1.27942611
63MP0010368_abnormal_lymphatic_system1.27392392
64MP0004924_abnormal_behavior1.27336629
65MP0005386_behavior/neurological_phenoty1.27336629
66MP0002086_abnormal_extraembryonic_tissu1.26956691
67MP0003646_muscle_fatigue1.25665884
68MP0002067_abnormal_sensory_capabilities1.23462562
69MP0002938_white_spotting1.23260305
70MP0008007_abnormal_cellular_replicative1.23062027
71MP0000653_abnormal_sex_gland1.23011438
72MP0005551_abnormal_eye_electrophysiolog1.22292830
73MP0002928_abnormal_bile_duct1.21740426
74MP0003283_abnormal_digestive_organ1.21284950
75MP0001145_abnormal_male_reproductive1.20850704
76MP0003935_abnormal_craniofacial_develop1.19461854
77MP0004233_abnormal_muscle_weight1.19108148
78MP0003183_abnormal_peptide_metabolism1.18989856
79MP0002734_abnormal_mechanical_nocicepti1.18603630
80MP0005380_embryogenesis_phenotype1.18325701
81MP0001672_abnormal_embryogenesis/_devel1.18325701
82MP0006054_spinal_hemorrhage1.18063965
83MP0001697_abnormal_embryo_size1.17376813
84MP0001970_abnormal_pain_threshold1.15963165
85MP0005174_abnormal_tail_pigmentation1.15871157
86MP0002085_abnormal_embryonic_tissue1.15150408
87MP0004808_abnormal_hematopoietic_stem1.13319723
88MP0000013_abnormal_adipose_tissue1.12454174
89MP0003984_embryonic_growth_retardation1.12370286
90MP0002161_abnormal_fertility/fecundity1.12267489
91MP0000350_abnormal_cell_proliferation1.11530200
92MP0003091_abnormal_cell_migration1.10399510
93MP0006072_abnormal_retinal_apoptosis1.08459812
94MP0009703_decreased_birth_body1.07891958
95MP0002088_abnormal_embryonic_growth/wei1.07586821
96MP0001299_abnormal_eye_distance/1.07297598
97MP0002184_abnormal_innervation1.06788909
98MP0003136_yellow_coat_color1.06529266
99MP0003937_abnormal_limbs/digits/tail_de1.06261030
100MP0002909_abnormal_adrenal_gland1.04474074
101MP0009046_muscle_twitch1.03930701
102MP0005645_abnormal_hypothalamus_physiol1.03173117
103MP0003943_abnormal_hepatobiliary_system1.02722136
104MP0004742_abnormal_vestibular_system1.00681027
105MP0000955_abnormal_spinal_cord1.00457423
106MP0008058_abnormal_DNA_repair0.99497548
107MP0001177_atelectasis0.99076858
108MP0008875_abnormal_xenobiotic_pharmacok0.99002455
109MP0010678_abnormal_skin_adnexa0.98515167
110MP0002234_abnormal_pharynx_morphology0.98464404
111MP0006292_abnormal_olfactory_placode0.97832109
112MP0005171_absent_coat_pigmentation0.97090925
113MP0002882_abnormal_neuron_morphology0.96900669
114MP0003115_abnormal_respiratory_system0.96635316
115MP0008872_abnormal_physiological_respon0.96577648
116MP0003633_abnormal_nervous_system0.96133581
117MP0000428_abnormal_craniofacial_morphol0.95154906
118MP0004142_abnormal_muscle_tone0.95133618
119MP0001963_abnormal_hearing_physiology0.94873849
120MP0002733_abnormal_thermal_nociception0.94797256
121MP0004084_abnormal_cardiac_muscle0.94639261
122MP0002229_neurodegeneration0.93295614
123MP0002925_abnormal_cardiovascular_devel0.91592475
124MP0001915_intracranial_hemorrhage0.91021604
125MP0001270_distended_abdomen0.90311444
126MP0004036_abnormal_muscle_relaxation0.89996361
127MP0003122_maternal_imprinting0.88690514
128MP0001944_abnormal_pancreas_morphology0.87280864
129MP0002233_abnormal_nose_morphology0.87033076
130MP0004957_abnormal_blastocyst_morpholog0.87011959
131MP0003693_abnormal_embryo_hatching0.87011767
132MP0000432_abnormal_head_morphology0.86737869
133MP0009745_abnormal_behavioral_response0.86035813
134MP0002752_abnormal_somatic_nervous0.85345532
135MP0002896_abnormal_bone_mineralization0.85263866
136MP0000647_abnormal_sebaceous_gland0.85256557
137MP0005248_abnormal_Harderian_gland0.85160162
138MP0001502_abnormal_circadian_rhythm0.84291099
139MP0002751_abnormal_autonomic_nervous0.84269648
140MP0005195_abnormal_posterior_eye0.84141747
141MP0003699_abnormal_female_reproductive0.83659477
142MP0004484_altered_response_of0.83556595
143MP0004197_abnormal_fetal_growth/weight/0.83108420
144MP0005621_abnormal_cell_physiology0.82144289
145MP0004130_abnormal_muscle_cell0.80256030
146MP0003755_abnormal_palate_morphology0.79596565
147MP0000631_abnormal_neuroendocrine_gland0.78418418
148MP0004085_abnormal_heartbeat0.77990615
149MP0004147_increased_porphyrin_level0.77714426
150MP0001984_abnormal_olfaction0.77226879
151MP0002095_abnormal_skin_pigmentation0.76860841
152MP0002653_abnormal_ependyma_morphology0.76527537
153MP0005167_abnormal_blood-brain_barrier0.76495810
154MP0002572_abnormal_emotion/affect_behav0.76280012
155MP0002160_abnormal_reproductive_system0.76200518
156MP0000749_muscle_degeneration0.76114248
157MP0003119_abnormal_digestive_system0.75431903
158MP0003861_abnormal_nervous_system0.74916735
159MP0002168_other_aberrant_phenotype0.74636731
160MP0002876_abnormal_thyroid_physiology0.74326000
161MP0004811_abnormal_neuron_physiology0.74142695
162MP0000026_abnormal_inner_ear0.74043290
163MP0002152_abnormal_brain_morphology0.73821476
164MP0002080_prenatal_lethality0.72924672
165MP0005391_vision/eye_phenotype0.72528940
166MP0005646_abnormal_pituitary_gland0.72070235
167MP0001968_abnormal_touch/_nociception0.72023743
168MP0003385_abnormal_body_wall0.71000080

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.44433664
2Chronic hepatic failure (HP:0100626)4.33997692
3Pancreatic cysts (HP:0001737)4.22179284
4True hermaphroditism (HP:0010459)4.20741592
5Hyperventilation (HP:0002883)4.04404098
6Medial flaring of the eyebrow (HP:0010747)3.84732404
7Gait imbalance (HP:0002141)3.61907798
8Papillary thyroid carcinoma (HP:0002895)3.60710854
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.55570715
10Congenital primary aphakia (HP:0007707)3.50724456
11Absent/shortened dynein arms (HP:0200106)3.15238531
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.15238531
13Genital tract atresia (HP:0001827)3.13548186
14Abnormality of the renal cortex (HP:0011035)3.09744439
15Nephrogenic diabetes insipidus (HP:0009806)3.07108623
16Vaginal atresia (HP:0000148)2.99401324
17Aplasia/Hypoplasia of the tongue (HP:0010295)2.95355060
18Volvulus (HP:0002580)2.94020929
19Poor coordination (HP:0002370)2.78735531
20Occipital encephalocele (HP:0002085)2.73766446
21Tubular atrophy (HP:0000092)2.66424166
22Intestinal atresia (HP:0011100)2.64095518
23Absent frontal sinuses (HP:0002688)2.62732219
24Congenital hepatic fibrosis (HP:0002612)2.57060904
25Chronic bronchitis (HP:0004469)2.53746429
26Abnormal respiratory motile cilium physiology (HP:0012261)2.51083058
27Abnormality of the fingertips (HP:0001211)2.50650208
28Rhinitis (HP:0012384)2.49492496
29Postaxial foot polydactyly (HP:0001830)2.45266701
30Molar tooth sign on MRI (HP:0002419)2.45223648
31Abnormality of midbrain morphology (HP:0002418)2.45223648
32Dialeptic seizures (HP:0011146)2.44913710
33Cerebral aneurysm (HP:0004944)2.37023014
34Anencephaly (HP:0002323)2.33389149
35Truncal obesity (HP:0001956)2.32094574
36Polydipsia (HP:0001959)2.30315395
37Abnormal drinking behavior (HP:0030082)2.30315395
38Urethral obstruction (HP:0000796)2.28582671
39Bronchiectasis (HP:0002110)2.28181573
40Tubulointerstitial abnormality (HP:0001969)2.25991094
41Gastrointestinal atresia (HP:0002589)2.25750835
42Impaired smooth pursuit (HP:0007772)2.23396060
43Broad-based gait (HP:0002136)2.20751609
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.19568087
45Oligodactyly (hands) (HP:0001180)2.19371917
46Absence seizures (HP:0002121)2.18591163
47Abnormal biliary tract physiology (HP:0012439)2.18272343
48Bile duct proliferation (HP:0001408)2.18272343
49Furrowed tongue (HP:0000221)2.15307933
50Sclerocornea (HP:0000647)2.15164011
51Postaxial hand polydactyly (HP:0001162)2.14490765
52Abnormality of the labia minora (HP:0012880)2.14054222
53Male infertility (HP:0003251)2.13904328
54Calf muscle hypertrophy (HP:0008981)2.13016124
55Fair hair (HP:0002286)2.11881712
56Thyroid carcinoma (HP:0002890)2.09463079
57Type II lissencephaly (HP:0007260)2.06665896
58Hemiparesis (HP:0001269)2.04491704
59Focal seizures (HP:0007359)2.02804735
60Sandal gap (HP:0001852)2.02347475
61Focal motor seizures (HP:0011153)2.02250139
62Abnormality of ocular smooth pursuit (HP:0000617)2.01983206
63Enlarged penis (HP:0000040)2.01880373
64Epileptic encephalopathy (HP:0200134)2.00186517
65Protruding tongue (HP:0010808)1.99576533
66Nephronophthisis (HP:0000090)1.97597351
67Macroorchidism (HP:0000053)1.96768569
68Cystic liver disease (HP:0006706)1.96012861
69Abnormality of chromosome stability (HP:0003220)1.95942414
70Transitional cell carcinoma of the bladder (HP:0006740)1.95039861
71Aplasia/Hypoplasia of the lens (HP:0008063)1.95031360
72Bowel diverticulosis (HP:0005222)1.95015120
73Genetic anticipation (HP:0003743)1.92580358
74Urinary bladder sphincter dysfunction (HP:0002839)1.91800491
75Muscle hypertrophy of the lower extremities (HP:0008968)1.90453598
76Congenital stationary night blindness (HP:0007642)1.90278879
77Subacute progressive viral hepatitis (HP:0006572)1.89374973
78Tented upper lip vermilion (HP:0010804)1.88550745
79Specific learning disability (HP:0001328)1.87934612
80Atonic seizures (HP:0010819)1.87011104
81Tubulointerstitial nephritis (HP:0001970)1.86353397
82Esophageal atresia (HP:0002032)1.86292955
83Left ventricular hypertrophy (HP:0001712)1.86229796
84Infertility (HP:0000789)1.85748202
85Heterotopia (HP:0002282)1.85397359
86Hypoplastic labia majora (HP:0000059)1.85221732
87Male pseudohermaphroditism (HP:0000037)1.84264730
88Short foot (HP:0001773)1.84154836
89Abnormality of the nasal septum (HP:0000419)1.82835887
90Bladder neoplasm (HP:0009725)1.82095847
91Bladder carcinoma (HP:0002862)1.82095847
92Broad foot (HP:0001769)1.81151902
93Abolished electroretinogram (ERG) (HP:0000550)1.80970475
94Abnormality of the lower motor neuron (HP:0002366)1.80544976
95Neoplasm of the adrenal cortex (HP:0100641)1.79917693
96Vertebral arch anomaly (HP:0008438)1.79863437
97Abnormal ciliary motility (HP:0012262)1.79647431
98Attenuation of retinal blood vessels (HP:0007843)1.78858683
99Deep philtrum (HP:0002002)1.78598490
100Termporal pattern (HP:0011008)1.78510114
101Insidious onset (HP:0003587)1.78510114
102Acute myeloid leukemia (HP:0004808)1.77424354
103Long eyelashes (HP:0000527)1.76846998
104Preaxial hand polydactyly (HP:0001177)1.76477348
105Polyuria (HP:0000103)1.75963678
106Prominent nasal bridge (HP:0000426)1.75498573
107Neoplasm of the oral cavity (HP:0100649)1.75432604
108Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.75225607
109Chromsome breakage (HP:0040012)1.75177540
110Renovascular hypertension (HP:0100817)1.75164985
111Resting tremor (HP:0002322)1.75020416
112Progressive cerebellar ataxia (HP:0002073)1.74661168
113Abnormal respiratory motile cilium morphology (HP:0005938)1.73038298
114Abnormal respiratory epithelium morphology (HP:0012253)1.73038298
115Narrow forehead (HP:0000341)1.72977790
116Abnormality of the renal medulla (HP:0100957)1.72450628
117Facial hemangioma (HP:0000329)1.71523653
118Absent speech (HP:0001344)1.71434770
119Abnormality of the ischium (HP:0003174)1.70794090
120Stomach cancer (HP:0012126)1.69998850
121Dysmetric saccades (HP:0000641)1.69649902
122Elfin facies (HP:0004428)1.69430663
123Narrow palate (HP:0000189)1.68916570
124Widely spaced teeth (HP:0000687)1.68735264
125Renal cortical cysts (HP:0000803)1.67863876
126Astrocytoma (HP:0009592)1.67689974
127Abnormality of the astrocytes (HP:0100707)1.67689974
128Shawl scrotum (HP:0000049)1.67598822
129Tubulointerstitial fibrosis (HP:0005576)1.67301238
130Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67226629
131Gaze-evoked nystagmus (HP:0000640)1.66711260
132Astigmatism (HP:0000483)1.66229186
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65889517
134Inability to walk (HP:0002540)1.64464611
135Vascular tortuosity (HP:0004948)1.64396754
136Increased corneal curvature (HP:0100692)1.63585807
137Keratoconus (HP:0000563)1.63585807
138Febrile seizures (HP:0002373)1.62811536
139Epileptiform EEG discharges (HP:0011182)1.62365152
140Hyperkalemia (HP:0002153)1.62231511
141Uterine leiomyosarcoma (HP:0002891)1.62138149
142Leiomyosarcoma (HP:0100243)1.62138149
143Glioma (HP:0009733)1.61983492
144Highly arched eyebrow (HP:0002553)1.61872426
145Impaired vibration sensation in the lower limbs (HP:0002166)1.61753027
146Obsessive-compulsive behavior (HP:0000722)1.60455856
147Abnormality of the labia majora (HP:0012881)1.60443933
148Capillary hemangiomas (HP:0005306)1.60090076
149Broad thumb (HP:0011304)1.59584277
150Hypoplastic ischia (HP:0003175)1.59530279
151Generalized hypopigmentation of hair (HP:0011358)1.59332897
152Visual hallucinations (HP:0002367)1.58926392
153Central scotoma (HP:0000603)1.58588654
154Excessive salivation (HP:0003781)1.57700524
155Drooling (HP:0002307)1.57700524
156Overriding aorta (HP:0002623)1.57262636
157Arterial tortuosity (HP:0005116)1.57100885
158Broad phalanges of the hand (HP:0009768)1.55278688
159Spondylolisthesis (HP:0003302)1.54033790
160Malignant gastrointestinal tract tumors (HP:0006749)1.53077743
161Gastrointestinal carcinoma (HP:0002672)1.53077743
162Pointed chin (HP:0000307)1.51826999
163High pitched voice (HP:0001620)1.51447029
164Aortic aneurysm (HP:0004942)1.51186913
165Hydroureter (HP:0000072)1.51033326
166Abnormality of the carotid arteries (HP:0005344)1.50063008
167Broad phalanx (HP:0006009)1.49300414
168Broad finger (HP:0001500)1.49257810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.14395422
2MAP4K23.50667208
3CDK122.74729289
4MAP3K42.62023558
5PRKD32.58596241
6MAP3K92.50821177
7MAP3K132.40828823
8FRK2.34329953
9OBSCN2.19005043
10LATS22.09133384
11PDK22.09017606
12MAPK132.08826905
13CDC72.07321932
14AKT31.96578281
15STK38L1.93648364
16WNK31.93361204
17MARK11.92612672
18BMPR1B1.84751561
19NTRK31.84526021
20STK31.79288454
21MAPK151.75608031
22KSR21.75226596
23MAP2K61.65471347
24STK381.63665046
25PDK41.58140020
26PDK31.58140020
27NEK21.55220155
28FGFR21.53513038
29EPHA41.52825998
30ERBB31.52644758
31TTK1.52550068
32PINK11.51180282
33SCYL21.50795409
34MAP3K21.49762579
35PNCK1.48562164
36TNIK1.45282462
37RAF11.44052996
38TAOK31.41055328
39NUAK11.40458209
40ADRBK21.36849839
41NEK61.35475756
42STK391.34488938
43TLK11.32335078
44KSR11.30848104
45DMPK1.29105509
46GRK11.28691831
47SGK21.22659588
48OXSR11.22606052
49PIK3CA1.22546698
50PLK31.22084682
51PAK61.21339453
52CAMK1G1.20872330
53RET1.17851894
54PTK2B1.13884390
55PHKG21.12792006
56PHKG11.12792006
57DAPK21.11718327
58RIPK11.08373783
59CDK91.07826486
60TIE11.06442114
61BCR1.05958146
62TRIM281.05829090
63CAMK1D1.02177779
64PDGFRA1.01056917
65EEF2K0.98947799
66BRAF0.96601625
67ATM0.95807388
68PLK20.95040206
69SGK30.94213872
70PRKCE0.93648030
71ZAK0.93448268
72MAP3K50.92443511
73MELK0.90924710
74PDGFRB0.90795957
75INSRR0.90771521
76CCNB10.89363836
77BRSK20.87644899
78CHEK10.86055184
79TEC0.85990615
80FER0.85634401
81CASK0.85120365
82EPHA30.84890934
83PRKCH0.84835088
84ALK0.84276155
85CHEK20.84188430
86TAOK20.84013455
87NLK0.81031665
88CAMKK10.79679510
89ERBB40.76548834
90CAMK10.74652068
91MAPK100.74208397
92TRPM70.73970670
93ACVR1B0.73597150
94MAP2K40.72448436
95SGK10.72073573
96PRKAA10.72045993
97WNK10.71535086
98HIPK20.70716486
99ADRBK10.70039009
100SIK20.69470890
101BRD40.68780414
102PRKAA20.65873467
103ARAF0.65690168
104PIK3CG0.64660779
105CAMKK20.64554521
106PASK0.64183567
107MARK30.63215872
108PRKCG0.62614450
109PKN10.61785155
110PLK10.61437654
111ATR0.61302835
112TYRO30.59880009
113CAMK2A0.58453985
114PAK30.58443859
115CSNK1G10.56227764
116CSNK1G20.55942001
117MUSK0.55087315
118PDK10.54876751
119MTOR0.54471730
120RIPK40.54329927
121MST40.54003287
122DYRK1A0.53753477
123MKNK20.53738736
124TAOK10.53416455
125CDK20.52894531
126FGFR30.52802558
127CAMK40.51311059
128CSNK1D0.51046739
129EIF2AK30.50643141
130MAPK140.50602166
131CDK10.49840276
132CDK60.48611603
133MAP3K70.48186054
134GSK3B0.47014986
135MAP2K70.46908094
136DYRK30.46580377
137SGK2230.46126764
138SGK4940.46126764
139MAPKAPK30.45450495
140VRK10.45393995
141NTRK20.45230377
142NTRK10.44750251
143PRKDC0.44731271
144PRKG10.44208460
145CDK50.44057918
146WNK40.44013634
147MINK10.43561634
148AURKB0.43485675
149JAK30.42845354
150NEK90.42844773
151STK110.42797037
152CDK30.41354880
153SRPK10.40779585
154CSNK1A1L0.40387070
155IRAK10.39924354
156PRKACA0.39229968
157PRKACB0.37757671
158ERBB20.36137805
159TGFBR10.35427283
160MAPKAPK50.32761492

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006502.37613570
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21342189
3Long-term potentiation_Homo sapiens_hsa047201.84875736
4Nicotine addiction_Homo sapiens_hsa050331.78854049
5Insulin secretion_Homo sapiens_hsa049111.75748054
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74278298
7Amphetamine addiction_Homo sapiens_hsa050311.72324789
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67045586
9Oocyte meiosis_Homo sapiens_hsa041141.61677243
10Circadian rhythm_Homo sapiens_hsa047101.58428948
11Dorso-ventral axis formation_Homo sapiens_hsa043201.56504955
12ABC transporters_Homo sapiens_hsa020101.52284957
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50450997
14Morphine addiction_Homo sapiens_hsa050321.49173356
15Linoleic acid metabolism_Homo sapiens_hsa005911.48264525
16Nitrogen metabolism_Homo sapiens_hsa009101.44010081
17Olfactory transduction_Homo sapiens_hsa047401.43982443
18Circadian entrainment_Homo sapiens_hsa047131.42044490
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40608937
20Histidine metabolism_Homo sapiens_hsa003401.38786954
21Synaptic vesicle cycle_Homo sapiens_hsa047211.37566886
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37379538
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37273323
24Propanoate metabolism_Homo sapiens_hsa006401.36660818
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.36364554
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.35858694
27mTOR signaling pathway_Homo sapiens_hsa041501.35503032
28Renin secretion_Homo sapiens_hsa049241.33807665
29Type II diabetes mellitus_Homo sapiens_hsa049301.32098809
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31686716
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30681702
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30614307
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25897479
34Tryptophan metabolism_Homo sapiens_hsa003801.24567129
35Estrogen signaling pathway_Homo sapiens_hsa049151.23917375
36Oxytocin signaling pathway_Homo sapiens_hsa049211.23348197
37Dopaminergic synapse_Homo sapiens_hsa047281.22056589
38beta-Alanine metabolism_Homo sapiens_hsa004101.21159560
39Cell cycle_Homo sapiens_hsa041101.20685970
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19637503
41GABAergic synapse_Homo sapiens_hsa047271.19546911
42Glutamatergic synapse_Homo sapiens_hsa047241.18474313
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17652533
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17364157
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17353661
46Chemical carcinogenesis_Homo sapiens_hsa052041.16073639
47Salivary secretion_Homo sapiens_hsa049701.15478451
48Glioma_Homo sapiens_hsa052141.14690200
49Cholinergic synapse_Homo sapiens_hsa047251.14441219
50Inositol phosphate metabolism_Homo sapiens_hsa005621.13573658
51Regulation of autophagy_Homo sapiens_hsa041401.12454236
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12169444
53Adherens junction_Homo sapiens_hsa045201.11305215
54Caffeine metabolism_Homo sapiens_hsa002321.11094866
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10142497
56Ether lipid metabolism_Homo sapiens_hsa005651.09471055
57Glucagon signaling pathway_Homo sapiens_hsa049221.09297843
58cAMP signaling pathway_Homo sapiens_hsa040241.08969719
59Basal transcription factors_Homo sapiens_hsa030221.08675496
60GnRH signaling pathway_Homo sapiens_hsa049121.05792940
61Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03739237
62Fatty acid biosynthesis_Homo sapiens_hsa000611.01318248
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.00515674
64Long-term depression_Homo sapiens_hsa047301.00392333
65Peroxisome_Homo sapiens_hsa041461.00302373
66Taste transduction_Homo sapiens_hsa047421.00223022
67Cocaine addiction_Homo sapiens_hsa050300.99481772
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99449243
69Thyroid hormone synthesis_Homo sapiens_hsa049180.99179880
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98372672
71Alcoholism_Homo sapiens_hsa050340.98354106
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98332145
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97231138
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94503060
75Gastric acid secretion_Homo sapiens_hsa049710.93575338
76MicroRNAs in cancer_Homo sapiens_hsa052060.92894432
77MAPK signaling pathway_Homo sapiens_hsa040100.91431470
78Cardiac muscle contraction_Homo sapiens_hsa042600.91169730
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90816240
80Type I diabetes mellitus_Homo sapiens_hsa049400.90563966
81Endometrial cancer_Homo sapiens_hsa052130.90349630
82FoxO signaling pathway_Homo sapiens_hsa040680.89569032
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89359982
84Melanogenesis_Homo sapiens_hsa049160.89080064
85Renal cell carcinoma_Homo sapiens_hsa052110.88244392
86TGF-beta signaling pathway_Homo sapiens_hsa043500.86699497
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86510829
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86097211
89RNA degradation_Homo sapiens_hsa030180.85687692
90Wnt signaling pathway_Homo sapiens_hsa043100.85654879
91Colorectal cancer_Homo sapiens_hsa052100.85342395
92ErbB signaling pathway_Homo sapiens_hsa040120.85093253
93Fanconi anemia pathway_Homo sapiens_hsa034600.84955806
94Choline metabolism in cancer_Homo sapiens_hsa052310.84737716
95Pancreatic cancer_Homo sapiens_hsa052120.84203810
96Prostate cancer_Homo sapiens_hsa052150.84105769
97mRNA surveillance pathway_Homo sapiens_hsa030150.83005727
98Calcium signaling pathway_Homo sapiens_hsa040200.82662768
99Selenocompound metabolism_Homo sapiens_hsa004500.82532481
100Lysine degradation_Homo sapiens_hsa003100.81750295
101Non-homologous end-joining_Homo sapiens_hsa034500.81644423
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.81015586
103Gap junction_Homo sapiens_hsa045400.80966836
104Hippo signaling pathway_Homo sapiens_hsa043900.77466200
105Fatty acid metabolism_Homo sapiens_hsa012120.77459867
106Focal adhesion_Homo sapiens_hsa045100.77392254
107VEGF signaling pathway_Homo sapiens_hsa043700.76244129
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.74825582
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74649621
110Systemic lupus erythematosus_Homo sapiens_hsa053220.73777384
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73766482
112Non-small cell lung cancer_Homo sapiens_hsa052230.70800795
113Prolactin signaling pathway_Homo sapiens_hsa049170.70494703
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70073239
115Serotonergic synapse_Homo sapiens_hsa047260.69551963
116Chronic myeloid leukemia_Homo sapiens_hsa052200.69176814
117Rap1 signaling pathway_Homo sapiens_hsa040150.67895145
118Melanoma_Homo sapiens_hsa052180.67294837
119Pancreatic secretion_Homo sapiens_hsa049720.67289745
120Ras signaling pathway_Homo sapiens_hsa040140.67157947
121Viral carcinogenesis_Homo sapiens_hsa052030.66203408
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65950668
123Proteoglycans in cancer_Homo sapiens_hsa052050.65521581
124Ovarian steroidogenesis_Homo sapiens_hsa049130.65472701
125Dilated cardiomyopathy_Homo sapiens_hsa054140.64977643
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.64777635
127p53 signaling pathway_Homo sapiens_hsa041150.64555675
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.63975522
129Axon guidance_Homo sapiens_hsa043600.63383464
130HTLV-I infection_Homo sapiens_hsa051660.63025618
131Phototransduction_Homo sapiens_hsa047440.62746243
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62074923
133Small cell lung cancer_Homo sapiens_hsa052220.62017210
134RNA transport_Homo sapiens_hsa030130.61987579
135Glycerolipid metabolism_Homo sapiens_hsa005610.61967715
136Retinol metabolism_Homo sapiens_hsa008300.61369211
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60557032
138Fatty acid degradation_Homo sapiens_hsa000710.60168141
139Platelet activation_Homo sapiens_hsa046110.59303291
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59139738
141Homologous recombination_Homo sapiens_hsa034400.59084400
142Tight junction_Homo sapiens_hsa045300.57551004
143Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53965388
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53420186
145Hedgehog signaling pathway_Homo sapiens_hsa043400.52546131
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51653212
147Mineral absorption_Homo sapiens_hsa049780.47368653
148Bile secretion_Homo sapiens_hsa049760.43372083
149Sphingolipid metabolism_Homo sapiens_hsa006000.43019202
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42609270

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