FAM174B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.73628088
2Golgi transport vesicle coating (GO:0048200)7.73628088
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.92921039
4protein retention in ER lumen (GO:0006621)6.49113191
5exocrine pancreas development (GO:0031017)5.76044981
6protein maturation by protein folding (GO:0022417)5.51328960
7regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.23090316
8negative regulation of potassium ion transmembrane transport (GO:1901380)4.91860730
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.85070641
10COPII vesicle coating (GO:0048208)4.70157272
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.65358225
12endocrine pancreas development (GO:0031018)4.58866157
13positive regulation of nuclease activity (GO:0032075)4.57857539
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.57241668
15cellular ketone body metabolic process (GO:0046950)4.41466366
16sarcomere organization (GO:0045214)4.36727062
17peptide hormone processing (GO:0016486)4.32285963
18axonemal dynein complex assembly (GO:0070286)4.29804781
19cilium movement (GO:0003341)4.26817850
20ketone body metabolic process (GO:1902224)4.20738578
21detection of calcium ion (GO:0005513)4.18808705
22regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.17148915
23axoneme assembly (GO:0035082)4.16222774
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.15188372
25glandular epithelial cell differentiation (GO:0002067)4.14692276
26regulation of nuclease activity (GO:0032069)4.09828001
27proline biosynthetic process (GO:0006561)4.03353227
28regulation of type B pancreatic cell apoptotic process (GO:2000674)4.00577024
29cardiac myofibril assembly (GO:0055003)3.99387607
30growth hormone secretion (GO:0030252)3.97589413
31endoplasmic reticulum unfolded protein response (GO:0030968)3.94981426
32glandular epithelial cell development (GO:0002068)3.91578844
33cilium or flagellum-dependent cell motility (GO:0001539)3.89687691
34cellular response to unfolded protein (GO:0034620)3.83904534
35ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.83358962
36epithelial cilium movement (GO:0003351)3.83313515
37relaxation of cardiac muscle (GO:0055119)3.82099235
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.78093597
39regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.75739568
40ER-nucleus signaling pathway (GO:0006984)3.75338527
41sequestering of metal ion (GO:0051238)3.73665204
42columnar/cuboidal epithelial cell development (GO:0002066)3.72204364
43bundle of His cell to Purkinje myocyte communication (GO:0086069)3.70658836
44tricarboxylic acid cycle (GO:0006099)3.70290341
45GDP-mannose metabolic process (GO:0019673)3.69973434
46cellular response to topologically incorrect protein (GO:0035967)3.68449776
474-hydroxyproline metabolic process (GO:0019471)3.64567120
48intestinal epithelial cell development (GO:0060576)3.63927236
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63244574
50ventricular cardiac muscle cell action potential (GO:0086005)3.56120943
51intestinal cholesterol absorption (GO:0030299)3.53300166
52regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.52717709
53type B pancreatic cell development (GO:0003323)3.48965333
54cardiac muscle contraction (GO:0060048)3.47386272
55membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.45213200
56toxin metabolic process (GO:0009404)3.40662117
57response to endoplasmic reticulum stress (GO:0034976)3.38270869
58negative regulation of hormone biosynthetic process (GO:0032353)3.38162047
59regulation of cilium movement (GO:0003352)3.35946258
60vesicle coating (GO:0006901)3.34370603
61protein targeting to Golgi (GO:0000042)3.32247031
62myofibril assembly (GO:0030239)3.31572813
63positive regulation of insulin secretion (GO:0032024)3.31014686
64cell communication involved in cardiac conduction (GO:0086065)3.31007695
65nitric oxide biosynthetic process (GO:0006809)3.27127664
66positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.26723780
67protein localization to Golgi apparatus (GO:0034067)3.25843028
68sarcoplasmic reticulum calcium ion transport (GO:0070296)3.25572194
69signal peptide processing (GO:0006465)3.21675230
70ER overload response (GO:0006983)3.21627229
71water-soluble vitamin biosynthetic process (GO:0042364)3.16607531
72respiratory chain complex IV assembly (GO:0008535)3.13573208
73insulin secretion (GO:0030073)3.11470985
74response to unfolded protein (GO:0006986)3.09430542
75membrane repolarization during action potential (GO:0086011)3.08398789
76cardiac muscle cell development (GO:0055013)3.08134034
77digestion (GO:0007586)3.07783030
78maintenance of protein localization in organelle (GO:0072595)3.07516381
79regulation of insulin secretion (GO:0050796)3.07295459
80heart trabecula formation (GO:0060347)3.05905584
81intra-Golgi vesicle-mediated transport (GO:0006891)3.05764566
82cell communication by electrical coupling (GO:0010644)3.04105247
83negative regulation of hormone metabolic process (GO:0032351)3.02827452
84plasma membrane repair (GO:0001778)3.02494412
85tricarboxylic acid metabolic process (GO:0072350)3.01820125
86peptidyl-proline hydroxylation (GO:0019511)3.00914123
87response to topologically incorrect protein (GO:0035966)2.96803232
88retrograde transport, vesicle recycling within Golgi (GO:0000301)2.96148398
89peptidyl-asparagine modification (GO:0018196)2.95229384
90protein N-linked glycosylation via asparagine (GO:0018279)2.94410889
91inositol phosphate catabolic process (GO:0071545)2.93758049
92regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.93428727
93regulation of calcium ion-dependent exocytosis (GO:0017158)2.92281365
94regulation of acrosome reaction (GO:0060046)2.91397242
95establishment of protein localization to Golgi (GO:0072600)2.90734284
96retinal cone cell development (GO:0046549)2.87811322
97positive regulation of macroautophagy (GO:0016239)2.85730263
98cardiac cell development (GO:0055006)2.85565424
99regulation of hexokinase activity (GO:1903299)2.84004861
100regulation of glucokinase activity (GO:0033131)2.84004861
101regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.83854483
102chemosensory behavior (GO:0007635)2.82488428
103positive regulation of glycolytic process (GO:0045821)2.81164666
104epithelial cell fate commitment (GO:0072148)2.80848636
105negative regulation of insulin secretion (GO:0046676)2.79954549
106protein hydroxylation (GO:0018126)2.76109675
107branched-chain amino acid catabolic process (GO:0009083)2.75651088
108regulation of membrane repolarization (GO:0060306)2.75076307
109actomyosin structure organization (GO:0031032)2.74396637
110regulation of peptide hormone secretion (GO:0090276)2.74175863
111negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.73243819
112negative regulation of calcium ion transmembrane transport (GO:1903170)2.73243819
113L-alpha-amino acid transmembrane transport (GO:1902475)2.71269387
114positive regulation of growth hormone secretion (GO:0060124)2.71075215
115negative regulation of potassium ion transport (GO:0043267)2.70964445
116regulation of autophagic vacuole assembly (GO:2000785)2.70303457
117protein N-linked glycosylation (GO:0006487)2.69479855
118regulation of actin filament-based movement (GO:1903115)2.69165931
119cytochrome complex assembly (GO:0017004)2.68988273
120regulation of peptide secretion (GO:0002791)2.68076068
121phosphorylated carbohydrate dephosphorylation (GO:0046838)2.67926052
122inositol phosphate dephosphorylation (GO:0046855)2.67926052
123peptide hormone secretion (GO:0030072)2.67815673
124phenylpropanoid metabolic process (GO:0009698)2.66622884
125calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.66466747
126peptide secretion (GO:0002790)2.66260109
127valine metabolic process (GO:0006573)2.65862418
128microtubule bundle formation (GO:0001578)2.65025669
129Golgi organization (GO:0007030)2.64758541
130negative regulation of nucleotide catabolic process (GO:0030812)2.62904537
131positive regulation of peptide hormone secretion (GO:0090277)2.62464567
132nodal signaling pathway (GO:0038092)2.61768840
133negative regulation of purine nucleotide catabolic process (GO:0033122)2.61205925
134negative regulation of glycoprotein biosynthetic process (GO:0010561)2.60752014
135NADH metabolic process (GO:0006734)2.60467714
136glutathione derivative metabolic process (GO:1901685)2.60031433
137glutathione derivative biosynthetic process (GO:1901687)2.60031433
138regulation of microtubule-based movement (GO:0060632)2.59944879
139nucleoside diphosphate catabolic process (GO:0009134)2.58695992
140polyol catabolic process (GO:0046174)2.54129016
141positive regulation of peptide secretion (GO:0002793)2.53133699
142glycerophospholipid catabolic process (GO:0046475)2.52741728
143toxin transport (GO:1901998)2.50618519
144intraciliary transport (GO:0042073)2.49366712
145xenobiotic catabolic process (GO:0042178)2.48111371
146vitamin transmembrane transport (GO:0035461)2.46991736
147motile cilium assembly (GO:0044458)2.44725316
148positive regulation of response to extracellular stimulus (GO:0032106)2.44222301
149positive regulation of response to nutrient levels (GO:0032109)2.44222301
150negative regulation of neurological system process (GO:0031645)2.42982977
151keratinocyte development (GO:0003334)2.42163542
152auditory receptor cell differentiation (GO:0042491)2.34634943
153righting reflex (GO:0060013)2.32201688
154somite rostral/caudal axis specification (GO:0032525)2.31655616
155regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.30229821
156innervation (GO:0060384)2.29152271
157negative regulation of cytosolic calcium ion concentration (GO:0051481)2.28911679
158sphingomyelin metabolic process (GO:0006684)2.28809792
159biotin metabolic process (GO:0006768)2.28794094
160lactate metabolic process (GO:0006089)2.27535201
161positive regulation of protein autophosphorylation (GO:0031954)2.27238943
162retinal rod cell development (GO:0046548)2.25974801
163signal transduction involved in regulation of gene expression (GO:0023019)2.24253470
164negative regulation of gluconeogenesis (GO:0045721)2.23707324
165dendritic spine morphogenesis (GO:0060997)2.23681523
166adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.23536848
167protein polyglutamylation (GO:0018095)2.21876218
168left/right pattern formation (GO:0060972)2.19620252
169cilium organization (GO:0044782)2.19573976
170regulation of short-term neuronal synaptic plasticity (GO:0048172)2.18826156
171protein localization to cilium (GO:0061512)2.18693217
172embryonic retina morphogenesis in camera-type eye (GO:0060059)2.17892671
173positive regulation of neurotransmitter transport (GO:0051590)2.17787107
174calcium ion import (GO:0070509)2.16628645
175brain morphogenesis (GO:0048854)2.15327961
176macroautophagy (GO:0016236)2.13207477
177response to pheromone (GO:0019236)2.12566194
178retinol metabolic process (GO:0042572)2.12348326
179cilium assembly (GO:0042384)2.11887213
180long term synaptic depression (GO:0060292)2.11390464
181regulation of vacuole organization (GO:0044088)2.10836339
182inner ear receptor cell development (GO:0060119)2.10824133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.61090708
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.04007953
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98188356
4GATA1_22025678_ChIP-Seq_K562_Human2.96943522
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.64913369
6* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.41140473
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.36723708
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27150962
9* TBX20_22080862_ChIP-Seq_HEART_Mouse2.15072513
10* TBX20_22328084_ChIP-Seq_HEART_Mouse2.15072513
11* PIAS1_25552417_ChIP-Seq_VCAP_Human2.13748752
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09971209
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07230291
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.02236819
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.02236819
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.02236819
17* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.99427195
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98712672
19* AHR_22903824_ChIP-Seq_MCF-7_Human1.97098881
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95716099
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.91331248
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88741136
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83159568
24* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82276041
25CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.81566272
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.78935357
27LXR_22292898_ChIP-Seq_THP-1_Human1.78536103
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76501261
29* ARNT_22903824_ChIP-Seq_MCF-7_Human1.74902736
30GBX2_23144817_ChIP-Seq_PC3_Human1.74646741
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74022457
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66710127
33ZNF263_19887448_ChIP-Seq_K562_Human1.64689910
34FOXM1_26456572_ChIP-Seq_MCF-7_Human1.62740854
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61249209
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60767686
37* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60663185
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57779829
39ER_23166858_ChIP-Seq_MCF-7_Human1.56663929
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.54938576
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54061927
42VDR_22108803_ChIP-Seq_LS180_Human1.50294096
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48968077
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47688178
45P300_19829295_ChIP-Seq_ESCs_Human1.46574228
46* ESR2_21235772_ChIP-Seq_MCF-7_Human1.45249242
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.44740016
48SMAD4_21799915_ChIP-Seq_A2780_Human1.43545806
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43154623
50ZNF274_21170338_ChIP-Seq_K562_Hela1.40091284
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39757081
52* AR_25329375_ChIP-Seq_VCAP_Human1.39132747
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.38189007
54SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36808437
55RACK7_27058665_Chip-Seq_MCF-7_Human1.35577104
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34849260
57FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.34197427
58IGF1R_20145208_ChIP-Seq_DFB_Human1.34029095
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.33313077
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.28348083
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28059137
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27455546
63* SMAD3_21741376_ChIP-Seq_HESCs_Human1.26317996
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26280650
65CREB1_26743006_Chip-Seq_LNCaP_Human1.26062945
66* RUNX1_27514584_Chip-Seq_MCF-7_Human1.25911697
67KDM2B_26808549_Chip-Seq_K562_Human1.25532389
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22829401
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21660300
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.19798035
71CLOCK_20551151_ChIP-Seq_293T_Human1.19685719
72TP63_22573176_ChIP-Seq_HFKS_Human1.18985127
73FUS_26573619_Chip-Seq_HEK293_Human1.17341275
74MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17190316
75* TP53_22573176_ChIP-Seq_HFKS_Human1.17045917
76SMC4_20622854_ChIP-Seq_HELA_Human1.16957125
77* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15674461
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15614230
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15570398
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.15411709
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15411709
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15147165
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14839026
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14210243
85CTCF_27219007_Chip-Seq_Bcells_Human1.14073393
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14003651
87TAF15_26573619_Chip-Seq_HEK293_Human1.13674372
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13419431
89STAT3_23295773_ChIP-Seq_U87_Human1.13196287
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12174172
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12000807
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11999866
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11517012
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.11488269
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11414747
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11155744
97SOX2_20726797_ChIP-Seq_SW620_Human1.10644260
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10616798
99GATA1_19941826_ChIP-Seq_K562_Human1.10093132
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.09880795
101* TCF4_23295773_ChIP-Seq_U87_Human1.09866458
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.09792759
103TCF4_22108803_ChIP-Seq_LS180_Human1.09616578
104BCAT_22108803_ChIP-Seq_LS180_Human1.09525428
105NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09512767
106HOXB7_26014856_ChIP-Seq_BT474_Human1.07772531
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07068859
108TET1_21490601_ChIP-Seq_MESCs_Mouse1.06877677
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06494774
110* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06203610
111RUNX2_22187159_ChIP-Seq_PCA_Human1.06069707
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05110134
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04334322
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03483178
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02472041
116CBP_20019798_ChIP-Seq_JUKART_Human1.02472041
117* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02405284
118* ESR1_21235772_ChIP-Seq_MCF-7_Human1.02071922
119* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01529939
120EZH2_22144423_ChIP-Seq_EOC_Human1.00749591
121CDX2_22108803_ChIP-Seq_LS180_Human1.00128998
122GATA3_24758297_ChIP-Seq_MCF-7_Human0.99657399
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99577595
124CBX2_27304074_Chip-Seq_ESCs_Mouse0.98410921
125* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98262507
126REST_21632747_ChIP-Seq_MESCs_Mouse0.97727047
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.96969164
128FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96862620
129HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96746321
130P68_20966046_ChIP-Seq_HELA_Human0.96614480
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96605336
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96122542
133AR_20517297_ChIP-Seq_VCAP_Human0.95825508
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95765559
135RARB_27405468_Chip-Seq_BRAIN_Mouse0.95430007
136TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94906870
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94863372
138HTT_18923047_ChIP-ChIP_STHdh_Human0.94788443
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94652981
140ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94254761
141* GATA6_25053715_ChIP-Seq_YYC3_Human0.94182382
142EZH2_27294783_Chip-Seq_ESCs_Mouse0.93800221
143LXR_22158963_ChIP-Seq_LIVER_Mouse0.93560368
144NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93449136
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93334376
146SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92921275
147KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92625654
148RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92509109
149TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91998616
150TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91845089
151TRIM28_21343339_ChIP-Seq_HEK293_Human0.91551362
152ATF3_27146783_Chip-Seq_COLON_Human0.91190811
153E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91154414
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90526348
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.90044460
156RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89959558
157* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89502859
158ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89308912
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88413482
160* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87837593
161NANOG_19829295_ChIP-Seq_ESCs_Human0.87706291
162SOX2_19829295_ChIP-Seq_ESCs_Human0.87706291
163RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87267178
164NANOG_21062744_ChIP-ChIP_HESCs_Human0.87018414
165EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87016661
166RNF2_27304074_Chip-Seq_NSC_Mouse0.86642577
167GATA4_21415370_ChIP-Seq_HL-1_Mouse0.86202152
168ELF5_23300383_ChIP-Seq_T47D_Human0.85583342
169FOXO3_23340844_ChIP-Seq_DLD1_Human0.85360747
170NCOR_22424771_ChIP-Seq_293T_Human0.84390542
171FOXA2_19822575_ChIP-Seq_HepG2_Human0.84123066
172NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83904506
173KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83841016
174EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83535088
175* FOXA1_25552417_ChIP-Seq_VCAP_Human0.83454099
176ISL1_27105846_Chip-Seq_CPCs_Mouse0.83206432
177TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83091993
178GATA4_25053715_ChIP-Seq_YYC3_Human0.82813191
179BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82605974
180ETS1_21867929_ChIP-Seq_TH2_Mouse0.82423612
181SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81853029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.55989606
2MP0003283_abnormal_digestive_organ4.50612683
3MP0002877_abnormal_melanocyte_morpholog3.92162216
4MP0004084_abnormal_cardiac_muscle3.71629182
5MP0010234_abnormal_vibrissa_follicle3.61265313
6MP0004043_abnormal_pH_regulation3.48243757
7MP0002909_abnormal_adrenal_gland3.47502147
8MP0003787_abnormal_imprinting3.38540674
9MP0002693_abnormal_pancreas_physiology3.11877398
10MP0009780_abnormal_chondrocyte_physiolo3.07851569
11MP0004215_abnormal_myocardial_fiber2.89861250
12MP0003123_paternal_imprinting2.77537934
13MP0005220_abnormal_exocrine_pancreas2.71534373
14MP0004036_abnormal_muscle_relaxation2.66233838
15MP0001944_abnormal_pancreas_morphology2.65694834
16MP0000013_abnormal_adipose_tissue2.58638160
17MP0008877_abnormal_DNA_methylation2.53469865
18MP0005330_cardiomyopathy2.35278685
19MP0000751_myopathy2.32896726
20MP0004264_abnormal_extraembryonic_tissu2.30739073
21MP0000678_abnormal_parathyroid_gland2.30033985
22MP0004270_analgesia2.29671686
23MP0002163_abnormal_gland_morphology2.28729109
24MP0003183_abnormal_peptide_metabolism2.10094811
25MP0003137_abnormal_impulse_conducting2.00569940
26MP0002234_abnormal_pharynx_morphology1.99000173
27MP0003646_muscle_fatigue1.96332531
28MP0004133_heterotaxia1.94891261
29MP0009046_muscle_twitch1.91198753
30MP0002078_abnormal_glucose_homeostasis1.89815914
31MP0004233_abnormal_muscle_weight1.87104374
32MP0001984_abnormal_olfaction1.87007047
33MP0002972_abnormal_cardiac_muscle1.83161624
34MP0008961_abnormal_basal_metabolism1.80839695
35MP0000749_muscle_degeneration1.78227457
36MP0004085_abnormal_heartbeat1.76734792
37MP0002269_muscular_atrophy1.75994176
38MP0002876_abnormal_thyroid_physiology1.74575436
39MP0006072_abnormal_retinal_apoptosis1.70551686
40MP0005083_abnormal_biliary_tract1.70378829
41MP0003195_calcinosis1.69513469
42MP0001666_abnormal_nutrient_absorption1.68821773
43MP0000372_irregular_coat_pigmentation1.68127033
44MP0010678_abnormal_skin_adnexa1.67035116
45MP0005551_abnormal_eye_electrophysiolog1.66145060
46MP0010386_abnormal_urinary_bladder1.64109303
47MP0008775_abnormal_heart_ventricle1.62768166
48MP0002822_catalepsy1.61467841
49MP0005379_endocrine/exocrine_gland_phen1.59400696
50MP0000003_abnormal_adipose_tissue1.58174428
51MP0004087_abnormal_muscle_fiber1.57151793
52MP0002254_reproductive_system_inflammat1.55519550
53MP0010630_abnormal_cardiac_muscle1.54727278
54MP0004145_abnormal_muscle_electrophysio1.51794716
55MP0003121_genomic_imprinting1.50087032
56MP0004130_abnormal_muscle_cell1.49728149
57MP0003011_delayed_dark_adaptation1.43044478
58MP0005385_cardiovascular_system_phenoty1.41492812
59MP0001544_abnormal_cardiovascular_syste1.41492812
60MP0003828_pulmonary_edema1.41218775
61MP0004019_abnormal_vitamin_homeostasis1.40390433
62MP0000427_abnormal_hair_cycle1.40208125
63MP0005367_renal/urinary_system_phenotyp1.38112071
64MP0000516_abnormal_urinary_system1.38112071
65MP0005620_abnormal_muscle_contractility1.36344412
66MP0002734_abnormal_mechanical_nocicepti1.36198316
67MP0005365_abnormal_bile_salt1.33877575
68MP0006138_congestive_heart_failure1.33470210
69MP0002090_abnormal_vision1.33029535
70MP0002272_abnormal_nervous_system1.31922009
71MP0006036_abnormal_mitochondrial_physio1.29731712
72MP0000750_abnormal_muscle_regeneration1.28766267
73MP0005075_abnormal_melanosome_morpholog1.28580213
74MP0002557_abnormal_social/conspecific_i1.27123204
75MP0002106_abnormal_muscle_physiology1.24431558
76MP0000383_abnormal_hair_follicle1.21050763
77MP0001765_abnormal_ion_homeostasis1.20138577
78MP0002277_abnormal_respiratory_mucosa1.18277308
79MP0006276_abnormal_autonomic_nervous1.17881309
80MP0003122_maternal_imprinting1.17690289
81MP0002127_abnormal_cardiovascular_syste1.16300635
82MP0005253_abnormal_eye_physiology1.13430370
83MP0005408_hypopigmentation1.12927643
84MP0003953_abnormal_hormone_level1.12125426
85MP0008875_abnormal_xenobiotic_pharmacok1.11003052
86MP0003119_abnormal_digestive_system1.10969312
87MP0009745_abnormal_behavioral_response1.10936735
88MP0004484_altered_response_of1.10536533
89MP0002229_neurodegeneration1.10288679
90MP0002160_abnormal_reproductive_system1.09661332
91MP0000462_abnormal_digestive_system1.08955523
92MP0010368_abnormal_lymphatic_system1.08600793
93MP0003868_abnormal_feces_composition1.07840194
94MP0003718_maternal_effect1.07132858
95MP0000538_abnormal_urinary_bladder1.06127915
96MP0003959_abnormal_lean_body1.06035492
97MP0001188_hyperpigmentation1.05561187
98MP0001968_abnormal_touch/_nociception1.05343340
99MP0005332_abnormal_amino_acid1.05008799
100MP0000613_abnormal_salivary_gland1.03460368
101MP0005369_muscle_phenotype1.02848543
102MP0005165_increased_susceptibility_to1.01971715
103MP0002184_abnormal_innervation1.01789845
104MP0008872_abnormal_physiological_respon1.00833463
105MP0004782_abnormal_surfactant_physiolog1.00655876
106MP0005636_abnormal_mineral_homeostasis0.99851290
107MP0000759_abnormal_skeletal_muscle0.99157491
108MP0000747_muscle_weakness0.98813744
109MP0002572_abnormal_emotion/affect_behav0.97086391
110MP0005423_abnormal_somatic_nervous0.96686022
111MP0009643_abnormal_urine_homeostasis0.96270960
112MP0005375_adipose_tissue_phenotype0.95908417
113MP0003221_abnormal_cardiomyocyte_apopto0.92733709
114MP0002896_abnormal_bone_mineralization0.92439387
115MP0005187_abnormal_penis_morphology0.91290132
116MP0000230_abnormal_systemic_arterial0.90887420
117MP0003879_abnormal_hair_cell0.89684456
118MP0001905_abnormal_dopamine_level0.88125522
119MP0004885_abnormal_endolymph0.85686510
120MP0005171_absent_coat_pigmentation0.83903600
121MP0006054_spinal_hemorrhage0.83751615
122MP0003172_abnormal_lysosome_physiology0.82532061
123MP0003890_abnormal_embryonic-extraembry0.82502806
124MP0003045_fibrosis0.82193588
125MP0005535_abnormal_body_temperature0.82112565
126MP0005646_abnormal_pituitary_gland0.81973307
127MP0002928_abnormal_bile_duct0.81379824
128MP0002735_abnormal_chemical_nociception0.80226790
129MP0002102_abnormal_ear_morphology0.79980349
130MP0002064_seizures0.79852143
131MP0004924_abnormal_behavior0.79485202
132MP0005386_behavior/neurological_phenoty0.79485202
133MP0001485_abnormal_pinna_reflex0.79451090
134MP0002332_abnormal_exercise_endurance0.78225912
135MP0005058_abnormal_lysosome_morphology0.78114014
136MP0000266_abnormal_heart_morphology0.77692980
137MP0001501_abnormal_sleep_pattern0.76478719
138MP0005395_other_phenotype0.76356720
139MP0000639_abnormal_adrenal_gland0.75460696
140MP0001727_abnormal_embryo_implantation0.74539943
141MP0005448_abnormal_energy_balance0.74290159
142MP0001664_abnormal_digestion0.74002797
143MP0010329_abnormal_lipoprotein_level0.73799527
144MP0003635_abnormal_synaptic_transmissio0.72435769
145MP0002653_abnormal_ependyma_morphology0.71640375
146MP0005257_abnormal_intraocular_pressure0.71475186
147MP0005647_abnormal_sex_gland0.71111335
148MP0008995_early_reproductive_senescence0.70060360
149MP0001970_abnormal_pain_threshold0.69444464
150MP0002069_abnormal_eating/drinking_beha0.68942321
151MP0001502_abnormal_circadian_rhythm0.68853836
152MP0001756_abnormal_urination0.68757107
153MP0000371_diluted_coat_color0.68571119
154MP0002638_abnormal_pupillary_reflex0.68568570
155MP0001270_distended_abdomen0.66567100
156MP0004185_abnormal_adipocyte_glucose0.66232682
157MP0003300_gastrointestinal_ulcer0.66100628
158MP0004858_abnormal_nervous_system0.64196504
159MP0005666_abnormal_adipose_tissue0.63959114
160MP0005670_abnormal_white_adipose0.59457095
161MP0004510_myositis0.57728412
162MP0005645_abnormal_hypothalamus_physiol0.57717620
163MP0005266_abnormal_metabolism0.57164792
164MP0001879_abnormal_lymphatic_vessel0.54629323
165MP0002118_abnormal_lipid_homeostasis0.52247951
166MP0000470_abnormal_stomach_morphology0.49998445
167MP0000631_abnormal_neuroendocrine_gland0.49740809

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.13760610
2Hypoglycemic coma (HP:0001325)5.76276581
3Ketoacidosis (HP:0001993)5.43540580
4Hypoglycemic seizures (HP:0002173)5.17899629
5Large for gestational age (HP:0001520)4.77492892
6Pancreatic islet-cell hyperplasia (HP:0004510)4.67919879
7Sudden death (HP:0001699)4.56070898
8Abnormality of endocrine pancreas physiology (HP:0012093)4.53203797
9Abnormality of the pancreatic islet cells (HP:0006476)4.53203797
10Symptomatic seizures (HP:0011145)4.50098741
11Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.45761404
12Ventricular tachycardia (HP:0004756)4.31497578
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.26715002
14Insulin-resistant diabetes mellitus (HP:0000831)4.15901481
15Hyperglycemia (HP:0003074)4.08245220
16Chronic bronchitis (HP:0004469)4.00360295
17Rhinitis (HP:0012384)3.81069900
18Abnormal respiratory motile cilium physiology (HP:0012261)3.78348966
19Abnormal ciliary motility (HP:0012262)3.67759885
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.57901111
21Absent/shortened dynein arms (HP:0200106)3.57901111
22Syncope (HP:0001279)3.56819099
23Myoglobinuria (HP:0002913)3.52755176
24Atrial fibrillation (HP:0005110)3.52094532
25Abnormal respiratory epithelium morphology (HP:0012253)3.50528187
26Abnormal respiratory motile cilium morphology (HP:0005938)3.50528187
27Bundle branch block (HP:0011710)3.46861627
28Late onset (HP:0003584)3.44144558
29Palpitations (HP:0001962)3.41294549
30Asymmetric septal hypertrophy (HP:0001670)3.40662907
31Decreased circulating renin level (HP:0003351)3.35073349
32Right ventricular cardiomyopathy (HP:0011663)3.33075891
33Primary atrial arrhythmia (HP:0001692)3.30608616
34Ketosis (HP:0001946)3.28741688
35Prolonged QT interval (HP:0001657)3.27442262
36Supraventricular tachycardia (HP:0004755)3.16057773
37Supraventricular arrhythmia (HP:0005115)3.09599864
38Generalized aminoaciduria (HP:0002909)3.05341545
39Neoplasm of the adrenal cortex (HP:0100641)2.98137578
40Double outlet right ventricle (HP:0001719)2.95804568
41Congenital malformation of the right heart (HP:0011723)2.95804568
42Calf muscle hypertrophy (HP:0008981)2.91930168
43Ventricular fibrillation (HP:0001663)2.90735728
44Bronchiectasis (HP:0002110)2.89433811
45Urinary glycosaminoglycan excretion (HP:0003541)2.87080016
46Mucopolysacchariduria (HP:0008155)2.87080016
47Exercise-induced myalgia (HP:0003738)2.77397359
48Abnormal pancreas size (HP:0012094)2.77290361
49Pheochromocytoma (HP:0002666)2.74915262
50Testicular atrophy (HP:0000029)2.73486081
51Abnormality of the intrinsic pathway (HP:0010989)2.70412820
52Dysostosis multiplex (HP:0000943)2.65661601
53Ventricular arrhythmia (HP:0004308)2.64629067
54Hypothermia (HP:0002045)2.61516371
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.59487011
56Abnormality of polysaccharide metabolism (HP:0011012)2.59487011
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.59487011
58Abnormality of calcium-phosphate metabolism (HP:0100530)2.58211048
59Lipoatrophy (HP:0100578)2.57612246
60Tubulointerstitial nephritis (HP:0001970)2.57077065
61Dilated cardiomyopathy (HP:0001644)2.54255890
62Abnormal EKG (HP:0003115)2.52056967
63Hyperactive renin-angiotensin system (HP:0000841)2.52008341
64Gout (HP:0001997)2.51900946
65Insulin resistance (HP:0000855)2.51476700
66Epileptiform EEG discharges (HP:0011182)2.46897231
67Muscle hypertrophy of the lower extremities (HP:0008968)2.46071098
68Enlarged penis (HP:0000040)2.43904141
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.41243771
70Heart block (HP:0012722)2.41023091
71Progressive muscle weakness (HP:0003323)2.37502604
72Nephronophthisis (HP:0000090)2.36281663
73Abnormality of the left ventricular outflow tract (HP:0011103)2.36135565
74Subaortic stenosis (HP:0001682)2.36135565
75Pancreatic cysts (HP:0001737)2.34690643
76Hypokalemia (HP:0002900)2.33987914
77Pancreatic fibrosis (HP:0100732)2.31181077
78Neuroendocrine neoplasm (HP:0100634)2.29544535
79Hyporeflexia of lower limbs (HP:0002600)2.29540907
80Hyperphosphatemia (HP:0002905)2.28805678
81Abnormality of midbrain morphology (HP:0002418)2.27994015
82Molar tooth sign on MRI (HP:0002419)2.27994015
83Exocrine pancreatic insufficiency (HP:0001738)2.27570867
84Abnormal atrioventricular conduction (HP:0005150)2.26840535
85Aplasia/Hypoplasia of the fovea (HP:0008060)2.25231221
86Hypoplasia of the fovea (HP:0007750)2.25231221
87Abnormality of renin-angiotensin system (HP:0000847)2.24605840
88Hyperthyroidism (HP:0000836)2.22415321
89Atrioventricular block (HP:0001678)2.22270458
90Exercise-induced muscle cramps (HP:0003710)2.20192640
91Hypokinesia (HP:0002375)2.19544534
92Hyperparathyroidism (HP:0000843)2.18121045
93Methylmalonic acidemia (HP:0002912)2.17891631
94Medial flaring of the eyebrow (HP:0010747)2.17110512
95Hypomagnesemia (HP:0002917)2.16769014
96Hypercortisolism (HP:0001578)2.15060681
97Abnormality of the calf musculature (HP:0001430)2.14568002
98Left ventricular hypertrophy (HP:0001712)2.14128897
99Abnormality of the renal medulla (HP:0100957)2.12684956
100Abnormal rod and cone electroretinograms (HP:0008323)2.10013970
101Abnormality of the fovea (HP:0000493)2.05492129
102Infertility (HP:0000789)2.05065486
103True hermaphroditism (HP:0010459)2.04670738
104Maternal diabetes (HP:0009800)2.04119540
105Testicular neoplasm (HP:0010788)2.02596450
106Chronic hepatic failure (HP:0100626)2.02364505
107Mildly elevated creatine phosphokinase (HP:0008180)2.01486650
108Hyperkalemia (HP:0002153)1.98401207
109Hamartoma of the eye (HP:0010568)1.97508653
110Renal salt wasting (HP:0000127)1.96452975
111Tachypnea (HP:0002789)1.95166343
112Bony spicule pigmentary retinopathy (HP:0007737)1.95012728
113Abnormality of vitamin B metabolism (HP:0004340)1.94489407
114Hypotension (HP:0002615)1.94148706
115Diminished movement (HP:0002374)1.93660446
116Growth hormone excess (HP:0000845)1.92976383
117Skin nodule (HP:0200036)1.91921313
118Unilateral renal agenesis (HP:0000122)1.91398792
119Abnormality of potassium homeostasis (HP:0011042)1.90454642
120Muscular hypotonia of the trunk (HP:0008936)1.89602181
121Nuclear cataract (HP:0100018)1.89173458
122Prominent metopic ridge (HP:0005487)1.88460755
123Cystic liver disease (HP:0006706)1.88277821
124Gaze-evoked nystagmus (HP:0000640)1.87504508
125Adrenal overactivity (HP:0002717)1.85756882
126Agitation (HP:0000713)1.85752324
127Tubular atrophy (HP:0000092)1.85743934
128Muscle fiber splitting (HP:0003555)1.85230739
129Hyperventilation (HP:0002883)1.83214399
130Gait imbalance (HP:0002141)1.82238447
131Polycythemia (HP:0001901)1.81963719
132Broad-based gait (HP:0002136)1.81941540
133Congenital glaucoma (HP:0001087)1.81865061
134Abnormality of magnesium homeostasis (HP:0004921)1.81851341
135Abdominal situs inversus (HP:0003363)1.79590398
136Abnormality of abdominal situs (HP:0011620)1.79590398
137EMG: neuropathic changes (HP:0003445)1.79482006
138Vascular calcification (HP:0004934)1.79112157
139Abnormality of the renal cortex (HP:0011035)1.78815875
140Limb hypertonia (HP:0002509)1.77726105
141Hepatic necrosis (HP:0002605)1.76580882
142Neoplasm of the adrenal gland (HP:0100631)1.76103627
143Ragged-red muscle fibers (HP:0003200)1.75560063
144Aplasia/hypoplasia of the uterus (HP:0008684)1.75199829
145Multiple enchondromatosis (HP:0005701)1.73855490
146Male pseudohermaphroditism (HP:0000037)1.73735606
147Tongue fasciculations (HP:0001308)1.73524470
148Methylmalonic aciduria (HP:0012120)1.73256006
149Hypoplastic ischia (HP:0003175)1.72267671
150Dicarboxylic aciduria (HP:0003215)1.69664677
151Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69664677
152Myotonia (HP:0002486)1.69559656
153Congenital primary aphakia (HP:0007707)1.69415148
154Resting tremor (HP:0002322)1.69262800
155Glycosuria (HP:0003076)1.69125269
156Abnormality of urine glucose concentration (HP:0011016)1.69125269
157EEG with generalized epileptiform discharges (HP:0011198)1.67884186
158Hypsarrhythmia (HP:0002521)1.67859857
159Occipital encephalocele (HP:0002085)1.67139668
160Dysautonomia (HP:0002459)1.66561852
161Breast carcinoma (HP:0003002)1.66484670
162Abnormality of vitamin metabolism (HP:0100508)1.66065200
163Abnormal sex determination (HP:0012244)1.65902838
164Sex reversal (HP:0012245)1.65902838
165Visual hallucinations (HP:0002367)1.63857302
166Poor suck (HP:0002033)1.63178343
167Macroorchidism (HP:0000053)1.63076225
168Concave nail (HP:0001598)1.61341553
169Amelogenesis imperfecta (HP:0000705)1.60480304
170Abnormality of the parathyroid morphology (HP:0011766)1.60390802
171Abnormality of the metopic suture (HP:0005556)1.60048373
172Genital tract atresia (HP:0001827)1.58708474
173Aqueductal stenosis (HP:0002410)1.58672983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.24243445
2MAPK154.04615679
3ERN13.46431931
4PASK3.20968737
5BCKDK3.04645085
6TRIB32.83396434
7MST42.64269775
8HIPK22.43795360
9TRIM282.41455036
10CASK2.39331937
11FGFR22.32864555
12TAOK32.28043050
13EPHA22.23194546
14PRKD32.18975178
15STK162.10300895
16PDGFRA2.05023612
17TTN2.02784526
18LMTK22.00793628
19PHKG11.98119839
20PHKG21.98119839
21TIE11.97744156
22MAP3K121.95858121
23WNK41.91196137
24ACVR1B1.90830090
25TAF11.86841313
26STK38L1.84455947
27FLT31.82349450
28PKN21.80359973
29MAP3K91.78716031
30DAPK21.77479822
31PINK11.74021657
32NUAK11.70523446
33BMPR1B1.70376708
34FRK1.69989031
35VRK21.66366853
36UHMK11.66355898
37MAP3K21.61222496
38MAP3K41.59574358
39CDC42BPA1.58001961
40MYLK1.57357688
41STK391.52937939
42TNIK1.49944522
43ICK1.46326288
44TAOK11.43546864
45PDK41.42405833
46PDK31.42405833
47MAP2K61.39677503
48PRKD21.38822284
49AKT31.36502875
50GRK71.33861939
51PAK31.31723945
52GRK51.30091523
53CSNK1G11.28145762
54DMPK1.24900916
55NTRK11.24538306
56MAP3K11.20479820
57CSNK1G21.18149798
58CSNK1G31.12830717
59OXSR11.11711646
60MAPKAPK31.07486689
61ZAK1.07418681
62DYRK1B1.05970720
63PRKD11.03059996
64RPS6KB21.01194727
65TGFBR21.00161716
66MAP2K71.00052614
67TNK20.99417724
68NME10.97029363
69CAMK2D0.96937751
70EIF2AK30.96639730
71SCYL20.96551696
72PRKAA10.96244107
73WNK10.95464907
74PRKCH0.93268961
75RIPK10.92713151
76PTK60.90935352
77DDR20.87990320
78MAP2K20.87929442
79PDK20.85852453
80PTK20.84450700
81CSNK1A1L0.82581945
82MINK10.82494604
83TESK10.82032031
84MAP4K20.81048573
85PRKCG0.81042423
86CAMKK20.79563485
87MAP3K60.78541328
88WNK30.77692101
89FER0.76070370
90BCR0.74591015
91TYRO30.73964545
92MATK0.73332138
93DYRK20.72814114
94CAMK1G0.71774349
95MET0.71520055
96SMG10.70877559
97ADRBK20.69751585
98STK30.68631069
99EPHA30.67828377
100LATS10.67141930
101CSNK1A10.66408359
102CDK120.62512443
103PTK2B0.60901794
104CAMK1D0.58889011
105SGK20.58738713
106PIK3CA0.58476819
107PDGFRB0.58028852
108PRKCE0.57822024
109STK110.57328597
110SIK10.56356249
111BRSK20.56171006
112MTOR0.55787569
113OBSCN0.55094997
114CAMK40.54750188
115MAPK130.54676957
116RET0.53715010
117MARK20.52884675
118CSNK1E0.52778175
119NTRK30.52049553
120GSK3A0.51740902
121RPS6KC10.49640486
122RPS6KL10.49640486
123MKNK20.49548579
124PRKCZ0.47171456
125PRKG20.46966819
126CSK0.46879903
127NEK60.46784237
128PLK30.46366085
129PRKACG0.46123210
130JAK20.45031107
131MAP3K30.44624085
132MAPKAPK50.43726134
133IRAK10.43476198
134PNCK0.43267794
135SGK2230.42930221
136SGK4940.42930221
137MAP2K40.42822677
138ADRBK10.42731389
139MUSK0.42088205
140CHUK0.41475015
141SIK30.40520752
142MARK10.40305954
143PRKACA0.39435269
144DAPK10.39244244
145GRK10.38045621
146PRKAA20.38023691
147PRKCI0.37815036
148IRAK20.36186720
149CAMK2A0.35870687
150STK240.35244710
151RPS6KA60.34944235
152MAP3K110.34793115
153MST1R0.31003845
154KSR20.30388905
155RPS6KA20.29293350
156CAMKK10.28224555
157STK380.26527276
158ILK0.26226301
159RPS6KA10.24722106
160MAP2K10.23768226
161FGFR30.22516172
162ZAP700.22351491
163PRKACB0.21544574

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.95102892
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.90306289
3Protein export_Homo sapiens_hsa030603.63845919
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.90656409
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85130778
6Insulin secretion_Homo sapiens_hsa049112.64400663
7Pancreatic secretion_Homo sapiens_hsa049722.47962020
8Sulfur metabolism_Homo sapiens_hsa009202.23103290
9Vitamin B6 metabolism_Homo sapiens_hsa007502.10268141
10Type II diabetes mellitus_Homo sapiens_hsa049301.89922178
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82526462
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78182440
13Cardiac muscle contraction_Homo sapiens_hsa042601.75169271
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74304049
15Dilated cardiomyopathy_Homo sapiens_hsa054141.68845946
16Synaptic vesicle cycle_Homo sapiens_hsa047211.54695011
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53747113
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49022351
19Sphingolipid metabolism_Homo sapiens_hsa006001.48118605
20Propanoate metabolism_Homo sapiens_hsa006401.44528323
21Vibrio cholerae infection_Homo sapiens_hsa051101.44410800
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43752364
23Phototransduction_Homo sapiens_hsa047441.42788959
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40603622
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39183237
26Fat digestion and absorption_Homo sapiens_hsa049751.35112488
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34115801
28beta-Alanine metabolism_Homo sapiens_hsa004101.33193094
29Fatty acid degradation_Homo sapiens_hsa000711.29678699
30Oxidative phosphorylation_Homo sapiens_hsa001901.27548385
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25630045
32N-Glycan biosynthesis_Homo sapiens_hsa005101.25512304
33Chemical carcinogenesis_Homo sapiens_hsa052041.24774284
34Selenocompound metabolism_Homo sapiens_hsa004501.23962392
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23918790
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23373394
37Peroxisome_Homo sapiens_hsa041461.22957165
38Glutathione metabolism_Homo sapiens_hsa004801.22652479
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22592180
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19250111
41Parkinsons disease_Homo sapiens_hsa050121.17950914
42Protein digestion and absorption_Homo sapiens_hsa049741.17175244
43Alzheimers disease_Homo sapiens_hsa050101.16950765
44Galactose metabolism_Homo sapiens_hsa000521.15013719
45Vitamin digestion and absorption_Homo sapiens_hsa049771.14394040
46Insulin resistance_Homo sapiens_hsa049311.13609952
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13391862
48Circadian rhythm_Homo sapiens_hsa047101.13240033
49Taste transduction_Homo sapiens_hsa047421.13084471
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12642866
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11605799
52Glucagon signaling pathway_Homo sapiens_hsa049221.10874629
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10342665
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06358846
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.05449916
56Type I diabetes mellitus_Homo sapiens_hsa049401.01106480
57Tyrosine metabolism_Homo sapiens_hsa003500.99298623
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.98666735
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97763365
60Retinol metabolism_Homo sapiens_hsa008300.97213989
61Fatty acid metabolism_Homo sapiens_hsa012120.97165598
62mTOR signaling pathway_Homo sapiens_hsa041500.97148526
63Phenylalanine metabolism_Homo sapiens_hsa003600.97055542
64Histidine metabolism_Homo sapiens_hsa003400.92187396
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91654645
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88887006
67Fructose and mannose metabolism_Homo sapiens_hsa000510.88393840
68Tryptophan metabolism_Homo sapiens_hsa003800.87514661
69Other glycan degradation_Homo sapiens_hsa005110.87384486
70Lysosome_Homo sapiens_hsa041420.87267475
71Insulin signaling pathway_Homo sapiens_hsa049100.86242261
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86030330
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84728182
74Ether lipid metabolism_Homo sapiens_hsa005650.84501546
75Cocaine addiction_Homo sapiens_hsa050300.82579100
76Caffeine metabolism_Homo sapiens_hsa002320.81609676
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.81369960
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.79340906
79Starch and sucrose metabolism_Homo sapiens_hsa005000.78037506
80Amphetamine addiction_Homo sapiens_hsa050310.76119002
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76104523
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75881790
83Ovarian steroidogenesis_Homo sapiens_hsa049130.75361062
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75070342
85Carbon metabolism_Homo sapiens_hsa012000.72229508
86Butanoate metabolism_Homo sapiens_hsa006500.71489359
87Metabolic pathways_Homo sapiens_hsa011000.70021205
88Folate biosynthesis_Homo sapiens_hsa007900.69863945
89Nicotine addiction_Homo sapiens_hsa050330.69796717
90AMPK signaling pathway_Homo sapiens_hsa041520.68738597
91Thyroid hormone synthesis_Homo sapiens_hsa049180.68399884
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67727658
93Linoleic acid metabolism_Homo sapiens_hsa005910.67367121
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63962585
95Huntingtons disease_Homo sapiens_hsa050160.63259424
96Estrogen signaling pathway_Homo sapiens_hsa049150.61905523
97Renin secretion_Homo sapiens_hsa049240.61399716
98Long-term potentiation_Homo sapiens_hsa047200.60987621
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60470572
100Salivary secretion_Homo sapiens_hsa049700.59241245
101Regulation of autophagy_Homo sapiens_hsa041400.59167829
102Steroid biosynthesis_Homo sapiens_hsa001000.58364294
103Mineral absorption_Homo sapiens_hsa049780.57594885
104Circadian entrainment_Homo sapiens_hsa047130.57364668
105Lysine degradation_Homo sapiens_hsa003100.55980837
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55599166
107Long-term depression_Homo sapiens_hsa047300.53538657
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.52337665
109Dopaminergic synapse_Homo sapiens_hsa047280.51585526
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.51388104
111Cholinergic synapse_Homo sapiens_hsa047250.50576003
112Gastric acid secretion_Homo sapiens_hsa049710.49998036
113Glutamatergic synapse_Homo sapiens_hsa047240.49651376
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49518581
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49265869
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49043755
117cAMP signaling pathway_Homo sapiens_hsa040240.48558803
118Basal transcription factors_Homo sapiens_hsa030220.48456622
119Calcium signaling pathway_Homo sapiens_hsa040200.48353155
120GABAergic synapse_Homo sapiens_hsa047270.48290774
121Dorso-ventral axis formation_Homo sapiens_hsa043200.48237522
122Prolactin signaling pathway_Homo sapiens_hsa049170.47142761
123Arginine and proline metabolism_Homo sapiens_hsa003300.46870042
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46407645
125Pyruvate metabolism_Homo sapiens_hsa006200.46118729
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.45868468
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.45311871
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40995257
129Adherens junction_Homo sapiens_hsa045200.40792806
130Gap junction_Homo sapiens_hsa045400.40047515
131Arachidonic acid metabolism_Homo sapiens_hsa005900.39790074
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39354840
133Bladder cancer_Homo sapiens_hsa052190.38296415
134Thyroid cancer_Homo sapiens_hsa052160.35849382
135Notch signaling pathway_Homo sapiens_hsa043300.33927117
136Renin-angiotensin system_Homo sapiens_hsa046140.33916289
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33577997
138Tight junction_Homo sapiens_hsa045300.33369228
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32987568
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.32968256
141Collecting duct acid secretion_Homo sapiens_hsa049660.32696720
142Fatty acid elongation_Homo sapiens_hsa000620.32349679
143ABC transporters_Homo sapiens_hsa020100.31595310
144VEGF signaling pathway_Homo sapiens_hsa043700.30853389
145Serotonergic synapse_Homo sapiens_hsa047260.30520040

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