FAM174A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)8.88568301
2motile cilium assembly (GO:0044458)8.67778345
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.32425482
4axoneme assembly (GO:0035082)6.68001009
5left/right pattern formation (GO:0060972)5.86327175
6regulation of cilium movement (GO:0003352)5.68486529
7primary alcohol catabolic process (GO:0034310)4.86018481
8left/right axis specification (GO:0070986)4.63918828
9protein localization to cilium (GO:0061512)4.56732780
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55287588
11axon ensheathment in central nervous system (GO:0032291)4.37681822
12central nervous system myelination (GO:0022010)4.37681822
13microtubule bundle formation (GO:0001578)4.09747363
14intraciliary transport (GO:0042073)4.06367079
15ethanol metabolic process (GO:0006067)3.97888641
16ventricular system development (GO:0021591)3.94681465
17pyrimidine-containing compound transmembrane transport (GO:0072531)3.92735298
18response to xenobiotic stimulus (GO:0009410)3.88501562
19regulation of autophagic vacuole assembly (GO:2000785)3.86618361
20regulation of microtubule-based movement (GO:0060632)3.84354647
21negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.83822699
22cilium organization (GO:0044782)3.78619018
23neuronal action potential propagation (GO:0019227)3.77583915
24cilium assembly (GO:0042384)3.67687720
25diterpenoid biosynthetic process (GO:0016102)3.67347470
26vitamin transmembrane transport (GO:0035461)3.59200489
27regulation of vacuole organization (GO:0044088)3.56640754
28signal peptide processing (GO:0006465)3.53032689
29negative regulation of B cell mediated immunity (GO:0002713)3.46234946
30negative regulation of immunoglobulin mediated immune response (GO:0002890)3.46234946
31one-carbon compound transport (GO:0019755)3.39034284
32regulation of germinal center formation (GO:0002634)3.27626283
33negative regulation of humoral immune response (GO:0002921)3.27454531
34negative regulation of inclusion body assembly (GO:0090084)3.25486461
35cytoplasmic microtubule organization (GO:0031122)3.12936976
36microtubule-based movement (GO:0007018)3.08118109
37intracellular pH reduction (GO:0051452)3.04256051
38neutrophil activation involved in immune response (GO:0002283)3.03780133
39nucleoside diphosphate phosphorylation (GO:0006165)3.03579045
40protein maturation by protein folding (GO:0022417)3.03196964
41cellular component assembly involved in morphogenesis (GO:0010927)3.02268903
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01064146
43cilium morphogenesis (GO:0060271)2.99438766
44regulation of interleukin-5 production (GO:0032674)2.97618477
45hydrogen peroxide biosynthetic process (GO:0050665)2.97503005
46ethanol oxidation (GO:0006069)2.96658134
47fatty acid elongation (GO:0030497)2.95132044
48neurotransmitter biosynthetic process (GO:0042136)2.87045496
49positive regulation of mitochondrial fission (GO:0090141)2.86879880
50regulation of type B pancreatic cell apoptotic process (GO:2000674)2.86778428
51regulation of interleukin-13 production (GO:0032656)2.86651187
52pH reduction (GO:0045851)2.84114865
53negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.79474779
54tolerance induction (GO:0002507)2.74707448
55regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.71641112
56negative regulation of T cell differentiation in thymus (GO:0033085)2.71293688
57ferric iron transport (GO:0015682)2.68696090
58trivalent inorganic cation transport (GO:0072512)2.68696090
59negative regulation of interleukin-17 production (GO:0032700)2.67898940
60negative regulation of neurotransmitter secretion (GO:0046929)2.67175381
61positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.66475241
62cell projection assembly (GO:0030031)2.63302217
63negative regulation of neurotransmitter transport (GO:0051589)2.63278130
64glutathione derivative biosynthetic process (GO:1901687)2.62749973
65glutathione derivative metabolic process (GO:1901685)2.62749973
66skeletal muscle contraction (GO:0003009)2.61812192
67sperm capacitation (GO:0048240)2.59504882
68retinol metabolic process (GO:0042572)2.58850281
69synaptic vesicle exocytosis (GO:0016079)2.58468507
70regulation of neuron projection regeneration (GO:0070570)2.56734830
71regulation of axon regeneration (GO:0048679)2.56734830
72sialylation (GO:0097503)2.56367643
73sphingomyelin metabolic process (GO:0006684)2.55803592
74respiratory electron transport chain (GO:0022904)2.54893722
75synaptic vesicle maturation (GO:0016188)2.54000656
76positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.52990318
77reactive oxygen species biosynthetic process (GO:1903409)2.52633453
78phagosome maturation (GO:0090382)2.52385643
79electron transport chain (GO:0022900)2.52131011
80retinoic acid metabolic process (GO:0042573)2.49854482
81myelination (GO:0042552)2.48976389
82ensheathment of neurons (GO:0007272)2.48862123
83axon ensheathment (GO:0008366)2.48862123
84carnitine metabolic process (GO:0009437)2.48663385
85respiratory burst (GO:0045730)2.46933849
86primary alcohol metabolic process (GO:0034308)2.44157112
87long-chain fatty acid biosynthetic process (GO:0042759)2.42718571
88neuromuscular process controlling posture (GO:0050884)2.42179104
89regulation of inclusion body assembly (GO:0090083)2.40716033
90regulation of synaptic vesicle exocytosis (GO:2000300)2.40652573
91mannosylation (GO:0097502)2.40284489
92sarcoplasmic reticulum calcium ion transport (GO:0070296)2.38774013
93presynaptic membrane assembly (GO:0097105)2.37183283
94regulation of amyloid precursor protein catabolic process (GO:1902991)2.37101007
95creatine metabolic process (GO:0006600)2.36763946
96positive regulation of protein depolymerization (GO:1901881)2.34413437
97glycosphingolipid biosynthetic process (GO:0006688)2.34282952
98regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.33836042
99detection of calcium ion (GO:0005513)2.31915423
100magnesium ion transport (GO:0015693)2.31440188
101negative regulation of glycoprotein biosynthetic process (GO:0010561)2.28817978
102GPI anchor biosynthetic process (GO:0006506)2.28299926
103response to methylmercury (GO:0051597)2.28170631
104lung epithelium development (GO:0060428)2.28008815
105membrane budding (GO:0006900)2.26993757
106positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.26913058
107multicellular organismal water homeostasis (GO:0050891)2.26682177
108presynaptic membrane organization (GO:0097090)2.26624064
109ATP hydrolysis coupled proton transport (GO:0015991)2.25981786
110energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.25981786
111ER overload response (GO:0006983)2.25966014
112negative regulation of glycoprotein metabolic process (GO:1903019)2.25813278
113mitochondrion degradation (GO:0000422)2.25431623
114terpenoid biosynthetic process (GO:0016114)2.24629980
115regulation of synaptic vesicle transport (GO:1902803)2.23551411
116response to redox state (GO:0051775)2.23318654
117regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.23046052
118glycosylceramide metabolic process (GO:0006677)2.22224062
119neurotransmitter metabolic process (GO:0042133)2.20559298
120galactose metabolic process (GO:0006012)2.17237155
121regulation of vesicle fusion (GO:0031338)2.16578579
122amyloid precursor protein metabolic process (GO:0042982)2.16511808
123mast cell activation (GO:0045576)2.16223462
124positive regulation of synaptic transmission, GABAergic (GO:0032230)2.15845904
125sodium ion homeostasis (GO:0055078)2.15734850
126regulation of pigment cell differentiation (GO:0050932)2.14403762
127centriole assembly (GO:0098534)2.14004874
128negative regulation of amino acid transport (GO:0051956)2.13809586
129regulation of voltage-gated calcium channel activity (GO:1901385)2.13787876
130substantia nigra development (GO:0021762)2.12824315
131regulation of interleukin-17 production (GO:0032660)2.12801378
132neuron remodeling (GO:0016322)2.12690084
133detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.12243972
134detection of temperature stimulus involved in sensory perception (GO:0050961)2.12243972
135amyloid precursor protein catabolic process (GO:0042987)2.11594839
136gamma-aminobutyric acid signaling pathway (GO:0007214)2.11531160
137COPI coating of Golgi vesicle (GO:0048205)2.11497575
138Golgi transport vesicle coating (GO:0048200)2.11497575
139photoreceptor cell differentiation (GO:0046530)2.10845827
140eye photoreceptor cell differentiation (GO:0001754)2.10845827
141regulation of cell communication by electrical coupling (GO:0010649)2.10429259
142retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.09500805
143substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.09418806
144substrate-independent telencephalic tangential migration (GO:0021826)2.09418806
145polyketide metabolic process (GO:0030638)2.09352294
146doxorubicin metabolic process (GO:0044598)2.09352294
147daunorubicin metabolic process (GO:0044597)2.09352294
148positive regulation of tolerance induction (GO:0002645)2.09296933
149progesterone metabolic process (GO:0042448)2.08880674
150water homeostasis (GO:0030104)2.08217392
151hydrogen peroxide catabolic process (GO:0042744)2.07963984
152protein insertion into membrane (GO:0051205)2.07778192
153nucleoside diphosphate metabolic process (GO:0009132)2.07301466
154transferrin transport (GO:0033572)2.07053950
155negative regulation of synaptic transmission, GABAergic (GO:0032229)2.05492692
156eosinophil chemotaxis (GO:0048245)2.05427064
157transmission of nerve impulse (GO:0019226)2.03255672
158response to epinephrine (GO:0071871)2.02986506
159neuron cell-cell adhesion (GO:0007158)2.02942987
160negative regulation of calcium ion transmembrane transport (GO:1903170)2.02853716
161negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.02853716
162sequestering of metal ion (GO:0051238)2.01558873
163response to interferon-beta (GO:0035456)2.01375239
164protein localization to Golgi apparatus (GO:0034067)2.01146575
165negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.00175309
166axonemal dynein complex assembly (GO:0070286)13.5935991
167cilium or flagellum-dependent cell motility (GO:0001539)10.6503777
168cilium movement (GO:0003341)10.0310471
169regulation of beta-amyloid formation (GO:1902003)1.99565970
170positive regulation of oligodendrocyte differentiation (GO:0048714)1.99293983
171adult walking behavior (GO:0007628)1.98932710
172cellular copper ion homeostasis (GO:0006878)1.98449853
173negative regulation of calcium ion transport into cytosol (GO:0010523)1.97879206
174GPI anchor metabolic process (GO:0006505)1.97812845
175leukocyte degranulation (GO:0043299)1.97090899
176inner mitochondrial membrane organization (GO:0007007)1.96710445
177response to dietary excess (GO:0002021)1.96522428
178positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)1.95738842
179negative regulation of cation channel activity (GO:2001258)1.95350251
180oligodendrocyte differentiation (GO:0048709)1.94987291
181dopamine biosynthetic process (GO:0042416)1.94876990
182chaperone-mediated protein transport (GO:0072321)1.94847389
183preassembly of GPI anchor in ER membrane (GO:0016254)1.94308379
184anterograde synaptic vesicle transport (GO:0048490)1.92810761
185cellular potassium ion homeostasis (GO:0030007)1.92660626
186protein targeting to Golgi (GO:0000042)1.92228022
187copper ion homeostasis (GO:0055070)1.91974702
188nucleoside diphosphate catabolic process (GO:0009134)1.91814882
189mitochondrial ATP synthesis coupled proton transport (GO:0042776)1.91772422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.89026710
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.89680435
3EZH2_22144423_ChIP-Seq_EOC_Human2.82620057
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49840156
5GBX2_23144817_ChIP-Seq_PC3_Human2.40583249
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16483180
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.16053291
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.15195549
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01290754
10JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97336834
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97143797
12IRF8_22096565_ChIP-ChIP_GC-B_Human1.96538924
13MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96396822
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94381179
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88307314
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79605355
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78023567
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76662895
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76438273
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73740289
21ZNF263_19887448_ChIP-Seq_K562_Human1.71237530
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71148126
23TAF15_26573619_Chip-Seq_HEK293_Human1.67775164
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65906071
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65880516
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64772934
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64363406
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63869155
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63164871
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.59695558
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55168870
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54735808
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54422620
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.53515294
35VDR_22108803_ChIP-Seq_LS180_Human1.51803375
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45531191
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45531191
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.45416740
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44685019
40SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.42895584
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.41999386
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41716452
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.39008883
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38918174
45* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36451382
46REST_21632747_ChIP-Seq_MESCs_Mouse1.35919220
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35691841
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35491357
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34758887
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34307017
51IGF1R_20145208_ChIP-Seq_DFB_Human1.33386698
52* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32140058
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30877431
54STAT1_20625510_ChIP-Seq_HELA_Human1.29026304
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28190213
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26152288
57P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26096578
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.24621643
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22696845
60* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22656979
61RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22622665
62GATA1_22025678_ChIP-Seq_K562_Human1.21164852
63SCL_19346495_ChIP-Seq_HPC-7_Human1.20622650
64P300_19829295_ChIP-Seq_ESCs_Human1.19954629
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.19835612
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19517243
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19517243
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.19406158
69TET1_21490601_ChIP-Seq_MESCs_Mouse1.18655384
70SMC4_20622854_ChIP-Seq_HELA_Human1.18652044
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16939641
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16630242
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15928743
74ER_23166858_ChIP-Seq_MCF-7_Human1.15874706
75* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13209290
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.12083967
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10230896
78DROSHA_22980978_ChIP-Seq_HELA_Human1.09859445
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.09489357
80FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08557798
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.08225939
82TP63_22573176_ChIP-Seq_HFKS_Human1.07960041
83* TP63_23658742_ChIP-Seq_EP156T_Human1.06306540
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06237630
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06099423
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03357565
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03288878
88* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01589517
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01516024
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00925550
91SOX2_21211035_ChIP-Seq_LN229_Human1.00185688
92TP53_18474530_ChIP-ChIP_U2OS_Human0.99722053
93SMAD4_21799915_ChIP-Seq_A2780_Human0.99617126
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99180041
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98904448
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.98563669
97ZNF274_21170338_ChIP-Seq_K562_Hela0.98128766
98RUNX_20019798_ChIP-Seq_JUKART_Human0.98004424
99* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96551359
100AHR_22903824_ChIP-Seq_MCF-7_Human0.96007589
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95360258
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.94619448
103CTCF_27219007_Chip-Seq_Bcells_Human0.94598631
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94496687
105TAL1_26923725_Chip-Seq_HPCs_Mouse0.94127806
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93715424
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92578298
108YY1_22570637_ChIP-Seq_MALME-3M_Human0.92406117
109RXR_22158963_ChIP-Seq_LIVER_Mouse0.91302139
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89946602
111AR_25329375_ChIP-Seq_VCAP_Human0.89153600
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.88646910
113CTCF_20526341_ChIP-Seq_ESCs_Human0.88601977
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.88577609
115KDM2B_26808549_Chip-Seq_REH_Human0.88387724
116SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88329110
117SMAD3_21741376_ChIP-Seq_EPCs_Human0.87806637
118NANOG_19829295_ChIP-Seq_ESCs_Human0.87429010
119SOX2_19829295_ChIP-Seq_ESCs_Human0.87429010
120* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86597955
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86377626
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86344878
123* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85030056
124ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85029715
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84287103
126MYC_19829295_ChIP-Seq_ESCs_Human0.83104665
127PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82881018
128ERG_20517297_ChIP-Seq_VCAP_Human0.82401539
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82253609
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80667397
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.80127926
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79872700
133WT1_19549856_ChIP-ChIP_CCG9911_Human0.79698748
134SPI1_23127762_ChIP-Seq_K562_Human0.78993069
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78440152
136P68_20966046_ChIP-Seq_HELA_Human0.78406477
137* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78379453
138* NANOG_18555785_Chip-Seq_ESCs_Mouse0.78370190
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78079144
140RACK7_27058665_Chip-Seq_MCF-7_Human0.78074400
141* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77863765
142GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77824465
143STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77621234
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77501778
145RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77365588
146CBP_20019798_ChIP-Seq_JUKART_Human0.77160303
147IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77160303
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.76897009
149VDR_24787735_ChIP-Seq_THP-1_Human0.76581470
150* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.76510162
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.76340848
152MYB_21317192_ChIP-Seq_ERMYB_Mouse0.76264634
153SMRT_27268052_Chip-Seq_Bcells_Human0.76093678
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76042871
155PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75768224
156PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75478959
157GATA2_21666600_ChIP-Seq_HMVEC_Human0.75331171
158SOX2_20726797_ChIP-Seq_SW620_Human0.75257323
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75182128
160PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.74535977
161KLF5_25053715_ChIP-Seq_YYC3_Human0.74010610
162* P53_22387025_ChIP-Seq_ESCs_Mouse0.73791643
163* CMYC_18555785_Chip-Seq_ESCs_Mouse0.73059367
164FOXA1_21572438_ChIP-Seq_LNCaP_Human0.73020555
165P53_22127205_ChIP-Seq_FIBROBLAST_Human0.72909877
166AR_21572438_ChIP-Seq_LNCaP_Human0.72833217
167CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.71086297
168RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70233183
169RUNX1_27514584_Chip-Seq_MCF-7_Human0.70024274
170GATA3_24758297_ChIP-Seq_MCF-7_Human0.69951827
171BCL6_27268052_Chip-Seq_Bcells_Human0.69657020
172CBP_21632823_ChIP-Seq_H3396_Human0.69441444
173FLI1_21867929_ChIP-Seq_CD8_Mouse0.69410510
174TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.69182325
175AR_20517297_ChIP-Seq_VCAP_Human0.69002089
176TBX20_22328084_ChIP-Seq_HEART_Mouse0.68616524
177TBX20_22080862_ChIP-Seq_HEART_Mouse0.68616524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok4.40516697
2MP0002653_abnormal_ependyma_morphology3.63803869
3MP0003880_abnormal_central_pattern3.16235499
4MP0009780_abnormal_chondrocyte_physiolo3.15814949
5MP0002132_abnormal_respiratory_system2.81424415
6MP0004270_analgesia2.81202432
7MP0000920_abnormal_myelination2.80808201
8MP0005058_abnormal_lysosome_morphology2.67769528
9MP0004859_abnormal_synaptic_plasticity2.56635943
10MP0002277_abnormal_respiratory_mucosa2.56119127
11MP0005623_abnormal_meninges_morphology2.42257554
12MP0002272_abnormal_nervous_system2.08892471
13MP0003191_abnormal_cellular_cholesterol2.08514434
14MP0002064_seizures2.03516788
15MP0003724_increased_susceptibility_to2.02646377
16MP0003635_abnormal_synaptic_transmissio1.98099624
17MP0003195_calcinosis1.94206660
18MP0008789_abnormal_olfactory_epithelium1.92829659
19MP0009745_abnormal_behavioral_response1.87448053
20MP0002332_abnormal_exercise_endurance1.87051412
21MP0004043_abnormal_pH_regulation1.86169168
22MP0010386_abnormal_urinary_bladder1.85964698
23MP0001968_abnormal_touch/_nociception1.80594302
24MP0003329_amyloid_beta_deposits1.80468417
25MP0002837_dystrophic_cardiac_calcinosis1.76831978
26MP0001905_abnormal_dopamine_level1.76503674
27MP0004145_abnormal_muscle_electrophysio1.76336140
28MP0004133_heterotaxia1.76141325
29MP0009046_muscle_twitch1.75158730
30MP0004142_abnormal_muscle_tone1.73226705
31MP0002735_abnormal_chemical_nociception1.72627429
32MP0002736_abnormal_nociception_after1.67425846
33MP0000013_abnormal_adipose_tissue1.67162006
34MP0000751_myopathy1.66890607
35MP0009785_altered_susceptibility_to1.66224261
36MP0002734_abnormal_mechanical_nocicepti1.64026428
37MP0002148_abnormal_hypersensitivity_rea1.63866942
38MP0005310_abnormal_salivary_gland1.61601597
39MP0002876_abnormal_thyroid_physiology1.60424444
40MP0003172_abnormal_lysosome_physiology1.59590096
41MP0010234_abnormal_vibrissa_follicle1.59374220
42MP0001970_abnormal_pain_threshold1.59140679
43MP0002733_abnormal_thermal_nociception1.56040898
44MP0001835_abnormal_antigen_presentation1.55531795
45MP0001501_abnormal_sleep_pattern1.54877596
46MP0003690_abnormal_glial_cell1.54120574
47MP0002909_abnormal_adrenal_gland1.53981858
48MP0001529_abnormal_vocalization1.49358470
49MP0006082_CNS_inflammation1.48304659
50MP0001486_abnormal_startle_reflex1.46670035
51MP0003183_abnormal_peptide_metabolism1.44967671
52MP0001986_abnormal_taste_sensitivity1.43275397
53MP0001502_abnormal_circadian_rhythm1.39737482
54MP0005409_darkened_coat_color1.39080856
55MP0000749_muscle_degeneration1.39061843
56MP0005000_abnormal_immune_tolerance1.38883689
57MP0006276_abnormal_autonomic_nervous1.38130292
58MP0003806_abnormal_nucleotide_metabolis1.37543440
59MP0002572_abnormal_emotion/affect_behav1.37256848
60MP0000604_amyloidosis1.35593820
61MP0002693_abnormal_pancreas_physiology1.34229851
62MP0004510_myositis1.33570016
63MP0002063_abnormal_learning/memory/cond1.31834928
64MP0003075_altered_response_to1.31643208
65MP0005165_increased_susceptibility_to1.30700376
66MP0002067_abnormal_sensory_capabilities1.30674345
67MP0005671_abnormal_response_to1.29689988
68MP0003634_abnormal_glial_cell1.29208553
69MP0002419_abnormal_innate_immunity1.26995459
70MP0004019_abnormal_vitamin_homeostasis1.26457220
71MP0002090_abnormal_vision1.26449673
72MP0008260_abnormal_autophagy1.25379233
73MP0003633_abnormal_nervous_system1.24360545
74MP0002229_neurodegeneration1.24335923
75MP0005499_abnormal_olfactory_system1.24083913
76MP0005394_taste/olfaction_phenotype1.24083913
77MP0004742_abnormal_vestibular_system1.21491534
78MP0001440_abnormal_grooming_behavior1.21079832
79MP0005379_endocrine/exocrine_gland_phen1.17777110
80MP0003656_abnormal_erythrocyte_physiolo1.16666654
81MP0005535_abnormal_body_temperature1.16471634
82MP0004484_altered_response_of1.14833872
83MP0005025_abnormal_response_to1.14206029
84MP0005410_abnormal_fertilization1.14149071
85MP0004036_abnormal_muscle_relaxation1.13404573
86MP0008569_lethality_at_weaning1.11975167
87MP0004147_increased_porphyrin_level1.11698281
88MP0002638_abnormal_pupillary_reflex1.10076467
89MP0002168_other_aberrant_phenotype1.09786374
90MP0004130_abnormal_muscle_cell1.09594182
91MP0009840_abnormal_foam_cell1.09530722
92MP0003879_abnormal_hair_cell1.08279101
93MP0001765_abnormal_ion_homeostasis1.07900313
94MP0000465_gastrointestinal_hemorrhage1.06477348
95MP0005387_immune_system_phenotype1.04102644
96MP0001790_abnormal_immune_system1.04102644
97MP0000685_abnormal_immune_system1.03892949
98MP0003436_decreased_susceptibility_to1.03130247
99MP0005636_abnormal_mineral_homeostasis1.01520729
100MP0005166_decreased_susceptibility_to0.99913148
101MP0002723_abnormal_immune_serum0.99382458
102MP0000343_altered_response_to0.99103179
103MP0005164_abnormal_response_to0.98547102
104MP0006036_abnormal_mitochondrial_physio0.98292606
105MP0000747_muscle_weakness0.97795890
106MP0001188_hyperpigmentation0.97628781
107MP0001984_abnormal_olfaction0.94869490
108MP0003866_abnormal_defecation0.94247217
109MP0001542_abnormal_bone_strength0.93525778
110MP0002822_catalepsy0.93044236
111MP0001270_distended_abdomen0.92445117
112MP0005083_abnormal_biliary_tract0.92284678
113MP0009379_abnormal_foot_pigmentation0.92173446
114MP0003136_yellow_coat_color0.91442122
115MP0003303_peritoneal_inflammation0.91405170
116MP0002160_abnormal_reproductive_system0.91105285
117MP0002066_abnormal_motor_capabilities/c0.89064793
118MP0001944_abnormal_pancreas_morphology0.87926974
119MP0004883_abnormal_blood_vessel0.86708043
120MP0004924_abnormal_behavior0.86639719
121MP0005386_behavior/neurological_phenoty0.86639719
122MP0000681_abnormal_thyroid_gland0.86183018
123MP0000372_irregular_coat_pigmentation0.85830717
124MP0004215_abnormal_myocardial_fiber0.85781027
125MP0002972_abnormal_cardiac_muscle0.85564311
126MP0000955_abnormal_spinal_cord0.85471719
127MP0000230_abnormal_systemic_arterial0.85159096
128MP0004885_abnormal_endolymph0.84846532
129MP0010678_abnormal_skin_adnexa0.83568992
130MP0003631_nervous_system_phenotype0.82797601
131MP0002452_abnormal_antigen_presenting0.82335072
132MP0006035_abnormal_mitochondrial_morpho0.82120634
133MP0005645_abnormal_hypothalamus_physiol0.81687586
134MP0000015_abnormal_ear_pigmentation0.79819429
135MP0005620_abnormal_muscle_contractility0.79653235
136MP0004811_abnormal_neuron_physiology0.79294736
137MP0003646_muscle_fatigue0.79134122
138MP0005464_abnormal_platelet_physiology0.78552456
139MP0005174_abnormal_tail_pigmentation0.78018525
140MP0000750_abnormal_muscle_regeneration0.77990947
141MP0002295_abnormal_pulmonary_circulatio0.76764722
142MP0002078_abnormal_glucose_homeostasis0.76427423
143MP0002269_muscular_atrophy0.76077060
144MP0008874_decreased_physiological_sensi0.73461428
145MP0005646_abnormal_pituitary_gland0.71481277
146MP0004085_abnormal_heartbeat0.71172172
147MP0003186_abnormal_redox_activity0.70109854
148MP0001727_abnormal_embryo_implantation0.68672139

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.32755077
2Abnormal respiratory motile cilium morphology (HP:0005938)9.32755077
3Abnormal respiratory motile cilium physiology (HP:0012261)9.30350936
4Abnormal ciliary motility (HP:0012262)8.97821096
5Rhinitis (HP:0012384)8.68421148
6Chronic bronchitis (HP:0004469)6.77214269
7Bronchiectasis (HP:0002110)6.01371814
8Nasal polyposis (HP:0100582)5.79542627
9Abnormality of the nasal mucosa (HP:0000433)4.84699670
10Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.00302657
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.77388170
12Retinal dysplasia (HP:0007973)3.65941157
13Bronchitis (HP:0012387)3.56013039
14Infertility (HP:0000789)3.53418377
15Increased cerebral lipofuscin (HP:0011813)3.52823509
16Chronic sinusitis (HP:0011109)3.49095876
17Neurofibrillary tangles (HP:0002185)3.46182779
18Recurrent sinusitis (HP:0011108)3.38964233
19Male infertility (HP:0003251)3.34412797
20Vacuolated lymphocytes (HP:0001922)3.33785998
21Dysostosis multiplex (HP:0000943)3.25523227
22Occipital encephalocele (HP:0002085)3.24939226
23Focal motor seizures (HP:0011153)3.11618208
24Type II lissencephaly (HP:0007260)3.10046466
25Recurrent otitis media (HP:0000403)3.07785766
26Hyperactive renin-angiotensin system (HP:0000841)3.00851216
27Acute necrotizing encephalopathy (HP:0006965)2.91196314
28Progressive neurologic deterioration (HP:0002344)2.90095681
29Hypothermia (HP:0002045)2.88359780
30Abnormal mitochondria in muscle tissue (HP:0008316)2.87791777
31Supranuclear gaze palsy (HP:0000605)2.87188305
32Visual hallucinations (HP:0002367)2.82439452
33Neuroendocrine neoplasm (HP:0100634)2.80024679
34Pancreatic fibrosis (HP:0100732)2.75029708
35Renal Fanconi syndrome (HP:0001994)2.71016650
36Increased intramyocellular lipid droplets (HP:0012240)2.69060959
37True hermaphroditism (HP:0010459)2.65738665
38Abnormality of macrophages (HP:0004311)2.63439838
39Mitochondrial inheritance (HP:0001427)2.63420774
40Pheochromocytoma (HP:0002666)2.61514460
41Nonprogressive disorder (HP:0003680)2.50998916
42Atelectasis (HP:0100750)2.48836157
43Myokymia (HP:0002411)2.48534603
44Cerebral hemorrhage (HP:0001342)2.44188953
45Axonal loss (HP:0003447)2.43661729
46Increased hepatocellular lipid droplets (HP:0006565)2.41343429
47Recurrent abscess formation (HP:0002722)2.39337387
48Increased muscle lipid content (HP:0009058)2.37911634
49Progressive inability to walk (HP:0002505)2.37205104
50Progressive macrocephaly (HP:0004481)2.35658327
51Hepatocellular necrosis (HP:0001404)2.33767275
52Cerebral inclusion bodies (HP:0100314)2.31275710
53Atonic seizures (HP:0010819)2.31267219
54Molar tooth sign on MRI (HP:0002419)2.31251546
55Abnormality of midbrain morphology (HP:0002418)2.31251546
56Acute encephalopathy (HP:0006846)2.29322483
57Peripheral hypomyelination (HP:0007182)2.26555350
58Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.23872073
59Muscle hypertrophy of the lower extremities (HP:0008968)2.23841238
60Pancreatic cysts (HP:0001737)2.23450991
61Muscle fiber splitting (HP:0003555)2.20519506
62Lipid accumulation in hepatocytes (HP:0006561)2.18976385
63Gait imbalance (HP:0002141)2.17800471
64Urinary glycosaminoglycan excretion (HP:0003541)2.16742909
65Mucopolysacchariduria (HP:0008155)2.16742909
66Hepatic necrosis (HP:0002605)2.16332054
67Recurrent bacterial skin infections (HP:0005406)2.15508343
68Cystic liver disease (HP:0006706)2.13201995
69Eczematoid dermatitis (HP:0000976)2.08105163
70Medial flaring of the eyebrow (HP:0010747)2.07888504
71Slow saccadic eye movements (HP:0000514)2.07585098
72Loss of speech (HP:0002371)2.07497052
73Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07427220
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07427220
75Hyperparathyroidism (HP:0000843)2.06495944
76Congenital primary aphakia (HP:0007707)2.04513740
77Abnormality of magnesium homeostasis (HP:0004921)2.03928876
78Episodic fever (HP:0001954)2.02303300
79Anxiety (HP:0000739)2.02277034
80Hypomagnesemia (HP:0002917)2.00207072
81Degeneration of the lateral corticospinal tracts (HP:0002314)2.00129067
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00129067
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6530920
84Elevated erythrocyte sedimentation rate (HP:0003565)1.98990350
85Abnormality of glycolipid metabolism (HP:0010969)1.98481801
86Abnormality of liposaccharide metabolism (HP:0010968)1.98481801
87Abnormality of glycosphingolipid metabolism (HP:0004343)1.98481801
88Beaking of vertebral bodies (HP:0004568)1.97840276
89Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96029857
90Abnormality of polysaccharide metabolism (HP:0011012)1.96029857
91Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96029857
92Large for gestational age (HP:0001520)1.93717405
93Increased CSF lactate (HP:0002490)1.93230844
94Ankle clonus (HP:0011448)1.92892669
95Abnormality of renal resorption (HP:0011038)1.92416118
96Clumsiness (HP:0002312)1.92407532
97Nephronophthisis (HP:0000090)1.92033693
98Abnormality of aromatic amino acid family metabolism (HP:0004338)1.91875659
99Stomatitis (HP:0010280)1.91533125
100Parakeratosis (HP:0001036)1.90726049
101Dysmetria (HP:0001310)1.89227270
102Nephrogenic diabetes insipidus (HP:0009806)1.89164696
103Dialeptic seizures (HP:0011146)1.88273860
104Abnormality of calcium-phosphate metabolism (HP:0100530)1.88210653
105Hand muscle atrophy (HP:0009130)1.87891517
106Absence seizures (HP:0002121)1.86082816
107Increased circulating renin level (HP:0000848)1.85926721
108Leukodystrophy (HP:0002415)1.82870559
109Decreased circulating renin level (HP:0003351)1.82831128
110Calf muscle hypertrophy (HP:0008981)1.81137797
111Generalized tonic-clonic seizures (HP:0002069)1.78500780
112Rigidity (HP:0002063)1.78197031
113Onion bulb formation (HP:0003383)1.78014972
114Postaxial foot polydactyly (HP:0001830)1.77947995
115Mutism (HP:0002300)1.77772627
116Sensory axonal neuropathy (HP:0003390)1.77055686
117Chronic otitis media (HP:0000389)1.75615221
118Psychosis (HP:0000709)1.73558439
119Optic disc pallor (HP:0000543)1.72641528
120Hepatosplenomegaly (HP:0001433)1.72461308
121Segmental peripheral demyelination/remyelination (HP:0003481)1.72427605
122Epileptic encephalopathy (HP:0200134)1.71871051
123Myoclonus (HP:0001336)1.71529096
124Focal seizures (HP:0007359)1.70071907
125Poor speech (HP:0002465)1.69801523
126Hyperkalemia (HP:0002153)1.69435694
127Renal salt wasting (HP:0000127)1.68917533
128Absent/shortened dynein arms (HP:0200106)1.68660483
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.68660483
130Scanning speech (HP:0002168)1.68564419
131Tubulointerstitial nephritis (HP:0001970)1.67592848
132Exertional dyspnea (HP:0002875)1.66488096
133Fetal akinesia sequence (HP:0001989)1.65976976
134Choreoathetosis (HP:0001266)1.65967925
135Distal lower limb muscle weakness (HP:0009053)1.65337770
136Intention tremor (HP:0002080)1.65209334
137Action tremor (HP:0002345)1.64298734
138Recurrent skin infections (HP:0001581)1.63914614
139Spastic gait (HP:0002064)1.62963340
140Nephropathy (HP:0000112)1.62870994
141Limb-girdle muscle atrophy (HP:0003797)1.61498442
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.60881304
143Hyperaldosteronism (HP:0000859)1.60787511
144Vascular calcification (HP:0004934)1.59995016
145Congenital hepatic fibrosis (HP:0002612)1.58903396
146Furrowed tongue (HP:0000221)1.56027509
147Male pseudohermaphroditism (HP:0000037)1.53701405
148Absent speech (HP:0001344)1.48814668
149Anencephaly (HP:0002323)1.48382180
150Polyphagia (HP:0002591)1.47402531
151Exercise-induced myalgia (HP:0003738)1.42203944
152Upper limb amyotrophy (HP:0009129)1.41000157
153Distal upper limb amyotrophy (HP:0007149)1.41000157
154Absent frontal sinuses (HP:0002688)1.40965036
155Sclerocornea (HP:0000647)1.40738607
156Abnormality of the renal medulla (HP:0100957)1.40102040
157Oculomotor apraxia (HP:0000657)1.39876395
158Ventricular fibrillation (HP:0001663)1.39632267
159Hyponatremia (HP:0002902)1.37498501
160Chronic hepatic failure (HP:0100626)1.37033343
161Rimmed vacuoles (HP:0003805)1.36514079
162Muscle fiber inclusion bodies (HP:0100299)1.36124522
163Cardiovascular calcification (HP:0011915)1.36112270
164Torticollis (HP:0000473)1.36016825
165Limb dystonia (HP:0002451)1.35505700
166Recurrent bronchitis (HP:0002837)1.35187194
167Focal dystonia (HP:0004373)1.33853311
168Hypokalemic alkalosis (HP:0001949)1.33735972
169Abnormality of the calf musculature (HP:0001430)1.32994760
170Bell-shaped thorax (HP:0001591)1.32682117
171Gout (HP:0001997)1.32663075
172Mitral stenosis (HP:0001718)1.32097389
173Glucose intolerance (HP:0000833)1.31315943
174Abnormality of renin-angiotensin system (HP:0000847)1.29955105
175Absent rod-and cone-mediated responses on ERG (HP:0007688)1.29839890
176Sensorimotor neuropathy (HP:0007141)1.27038041
177Hypotension (HP:0002615)1.26231688
178Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.24961825
179Nemaline bodies (HP:0003798)1.24500969
180Growth hormone excess (HP:0000845)1.22926965
181Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.22659019
182Postaxial hand polydactyly (HP:0001162)1.21765933
183Urinary urgency (HP:0000012)1.21342500
184EMG: myopathic abnormalities (HP:0003458)1.18787021
185Craniofacial dystonia (HP:0012179)1.17783325
186Adrenal overactivity (HP:0002717)1.16062864
187Myoglobinuria (HP:0002913)1.15505200
188Nuclear cataract (HP:0100018)1.14254621
189Depression (HP:0000716)1.13894467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.56437906
2TESK13.53985213
3TNIK3.43004217
4STK392.86385862
5EPHA22.81758692
6CDK192.79612712
7LIMK12.61507051
8ARAF2.59847766
9MAPK152.59444741
10MAPKAPK32.21138493
11OXSR12.14416888
12MUSK2.10896618
13MAP3K122.10528127
14CAMKK22.04532670
15WNK42.00892527
16NTRK11.96893026
17EPHA31.94531941
18MAP3K111.92829471
19FES1.90384022
20MAP3K131.74851031
21NTRK31.58854499
22EPHB11.55747892
23MAP3K31.51827371
24GRK71.48337745
25KSR21.47958237
26MAP2K41.47407807
27MARK11.46057157
28EPHA41.43853674
29BLK1.42151515
30PBK1.40737429
31MAPKAPK51.38782115
32ERBB31.34297835
33MAP3K41.32510368
34STK381.31799367
35MAP3K91.29639544
36KIT1.25169691
37ADRBK21.23357286
38MAP3K11.23095486
39PIK3CG1.15865244
40IRAK41.14172850
41MAP3K61.11577221
42CAMK2D1.09782061
43IRAK11.07985419
44TBK11.07927742
45BMPR21.04663174
46MAP3K21.02670249
47CAMK2B1.01997041
48GRK51.01617668
49WNK10.99404429
50HIPK20.99325358
51MAP2K70.99119036
52GRK10.96869605
53PINK10.96228623
54UHMK10.94614555
55TAOK10.93635904
56DYRK1B0.93582197
57IKBKE0.92297433
58PDPK10.90945148
59TEC0.90327832
60STK240.89692471
61NME10.89577873
62TNK20.89472059
63TESK20.89358542
64INSRR0.86842468
65PRKCI0.86156033
66NEK60.86073723
67DAPK20.85994141
68MST40.85255655
69CSK0.83932931
70LMTK20.83865480
71CAMK2G0.82650467
72CASK0.82075831
73SYK0.82068695
74MAP3K50.80518348
75TXK0.79333111
76PKN10.79240391
77PDK10.78581494
78FGR0.77873969
79CAMK2A0.77844539
80CDK50.77740958
81TAOK30.76146508
82PHKG20.75744087
83PHKG10.75744087
84CSNK1A1L0.74897853
85MINK10.72834270
86NME20.72223228
87MAPK130.71953348
88MYLK0.71348211
89MOS0.71029582
90SCYL20.70417301
91DAPK10.70330496
92MAP4K10.68845278
93PRKCE0.68470754
94IRAK20.68138683
95CAMKK10.67366441
96WNK30.67317247
97RIPK10.66636797
98CAMK10.66490382
99ABL20.65090943
100TIE10.64638099
101PRKCQ0.63257833
102BMPR1B0.62030764
103BCKDK0.61765222
104PIK3CA0.61755959
105RAF10.61502901
106ZAP700.61156389
107BCR0.59672723
108FER0.59088576
109LCK0.59041299
110CSNK1G30.58540899
111CSNK1G10.58491230
112MAPK120.58279172
113PAK60.58127915
114PDK20.58087821
115OBSCN0.58035692
116STK160.58005291
117LRRK20.57177665
118PTK2B0.56682150
119MAP4K20.55988591
120FLT30.55541879
121LYN0.53315143
122CSNK1G20.53041757
123PAK30.52208704
124PRKG20.51956241
125PIM20.51185445
126TYK20.50622115
127PRKCG0.50333444
128TRIM280.50262076
129GRK60.48856245
130BTK0.48024355
131MARK20.46538046
132FYN0.46254769
133DAPK30.46197871
134MAP2K60.44904037
135HCK0.44511948
136CSF1R0.44403462
137JAK10.43943589
138MATK0.43879828
139AKT20.43543672
140BRAF0.40657010
141PRKCD0.40184025
142STK100.39507966
143PRKACA0.39495096
144TAOK20.36905182
145AURKA0.36554899
146PRKCZ0.35860019
147PRKD20.34259630
148ADRBK10.33148344

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.54801707
2Protein export_Homo sapiens_hsa030603.36645213
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.88747483
4Oxidative phosphorylation_Homo sapiens_hsa001902.86830762
5beta-Alanine metabolism_Homo sapiens_hsa004102.51184220
6Tyrosine metabolism_Homo sapiens_hsa003502.38520946
7Collecting duct acid secretion_Homo sapiens_hsa049662.32424343
8Chemical carcinogenesis_Homo sapiens_hsa052042.18338264
9Parkinsons disease_Homo sapiens_hsa050122.13336639
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11803716
11Alzheimers disease_Homo sapiens_hsa050102.07787437
12Synaptic vesicle cycle_Homo sapiens_hsa047212.01744973
13Vibrio cholerae infection_Homo sapiens_hsa051101.94877622
14Lysosome_Homo sapiens_hsa041421.93358499
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.88566062
16Rheumatoid arthritis_Homo sapiens_hsa053231.81800310
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.79874837
18Fatty acid elongation_Homo sapiens_hsa000621.78032169
19GABAergic synapse_Homo sapiens_hsa047271.66331557
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65589205
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60772250
22Glutathione metabolism_Homo sapiens_hsa004801.52186486
23Morphine addiction_Homo sapiens_hsa050321.52099094
24Insulin secretion_Homo sapiens_hsa049111.49676788
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.49504460
26Serotonergic synapse_Homo sapiens_hsa047261.47153610
27Peroxisome_Homo sapiens_hsa041461.45435776
28Sulfur metabolism_Homo sapiens_hsa009201.43789043
29Circadian entrainment_Homo sapiens_hsa047131.42857840
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42472127
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36971819
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35307776
33Sphingolipid metabolism_Homo sapiens_hsa006001.33581968
34Nicotine addiction_Homo sapiens_hsa050331.32879362
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32546578
36Cardiac muscle contraction_Homo sapiens_hsa042601.32076686
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31491078
38Type I diabetes mellitus_Homo sapiens_hsa049401.28313446
39Circadian rhythm_Homo sapiens_hsa047101.28227708
40Glutamatergic synapse_Homo sapiens_hsa047241.28138799
41Other glycan degradation_Homo sapiens_hsa005111.27156467
42Phagosome_Homo sapiens_hsa041451.25828435
43Long-term potentiation_Homo sapiens_hsa047201.23002150
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21488528
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20068511
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17357883
47Ether lipid metabolism_Homo sapiens_hsa005651.15862424
48Huntingtons disease_Homo sapiens_hsa050161.15701585
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14157170
50Amphetamine addiction_Homo sapiens_hsa050311.08998950
51Pancreatic secretion_Homo sapiens_hsa049721.07515443
52Dopaminergic synapse_Homo sapiens_hsa047281.07239628
53Renin secretion_Homo sapiens_hsa049241.06393073
54Cholinergic synapse_Homo sapiens_hsa047251.05112817
55Salivary secretion_Homo sapiens_hsa049701.04939375
56Long-term depression_Homo sapiens_hsa047301.00387616
57Taste transduction_Homo sapiens_hsa047420.99152441
58Cocaine addiction_Homo sapiens_hsa050300.97734029
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97470466
60Olfactory transduction_Homo sapiens_hsa047400.95965755
61Calcium signaling pathway_Homo sapiens_hsa040200.94831107
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94052569
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91483773
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.91135979
65Salmonella infection_Homo sapiens_hsa051320.89799890
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.89653912
67Caffeine metabolism_Homo sapiens_hsa002320.89586562
68Fatty acid degradation_Homo sapiens_hsa000710.88297183
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87486760
70Arginine and proline metabolism_Homo sapiens_hsa003300.86286968
71Leishmaniasis_Homo sapiens_hsa051400.86218643
72Gastric acid secretion_Homo sapiens_hsa049710.85182113
73Folate biosynthesis_Homo sapiens_hsa007900.84215716
74Pertussis_Homo sapiens_hsa051330.82373723
75Tuberculosis_Homo sapiens_hsa051520.82104311
76Retinol metabolism_Homo sapiens_hsa008300.80404275
77Malaria_Homo sapiens_hsa051440.79717294
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75771048
79Graft-versus-host disease_Homo sapiens_hsa053320.74496845
80Osteoclast differentiation_Homo sapiens_hsa043800.74188089
81Oxytocin signaling pathway_Homo sapiens_hsa049210.74035168
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72883309
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.72178139
84African trypanosomiasis_Homo sapiens_hsa051430.71085231
85Regulation of autophagy_Homo sapiens_hsa041400.70690460
86cAMP signaling pathway_Homo sapiens_hsa040240.68672163
87Steroid biosynthesis_Homo sapiens_hsa001000.68383493
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68338712
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67781465
90B cell receptor signaling pathway_Homo sapiens_hsa046620.67261880
91Fructose and mannose metabolism_Homo sapiens_hsa000510.67204366
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67113839
93Butanoate metabolism_Homo sapiens_hsa006500.64801430
94Allograft rejection_Homo sapiens_hsa053300.63695432
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62977811
96Galactose metabolism_Homo sapiens_hsa000520.62315203
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62274869
98Chemokine signaling pathway_Homo sapiens_hsa040620.62104903
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61977454
100Asthma_Homo sapiens_hsa053100.61934829
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61388942
102Prion diseases_Homo sapiens_hsa050200.59804274
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59653165
104Endocytosis_Homo sapiens_hsa041440.59111781
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58904960
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58499926
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.57873137
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56414213
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56193482
110Tight junction_Homo sapiens_hsa045300.56123195
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55621940
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53485350
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53348955
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52816641
115ABC transporters_Homo sapiens_hsa020100.52584424
116Starch and sucrose metabolism_Homo sapiens_hsa005000.51498152
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51117583
118Arachidonic acid metabolism_Homo sapiens_hsa005900.50700016
119Shigellosis_Homo sapiens_hsa051310.50605678
120Sulfur relay system_Homo sapiens_hsa041220.48748263
121Metabolic pathways_Homo sapiens_hsa011000.47525704
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47268918
123Type II diabetes mellitus_Homo sapiens_hsa049300.47148022
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47065258
125Linoleic acid metabolism_Homo sapiens_hsa005910.46822695
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46817564
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.46564566
128Dilated cardiomyopathy_Homo sapiens_hsa054140.46222944
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46096220
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.44716026
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43777848
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.43240394
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42339596
134GnRH signaling pathway_Homo sapiens_hsa049120.40877252
135Histidine metabolism_Homo sapiens_hsa003400.40229959
136Hepatitis C_Homo sapiens_hsa051600.40205260
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39874059
138Mineral absorption_Homo sapiens_hsa049780.39765945
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38211857
140Pentose phosphate pathway_Homo sapiens_hsa000300.38171261
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36506749
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36451781
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35770573

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