FAM172BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)9.41122858
2regulation of female gonad development (GO:2000194)9.11707480
3regulation of acrosome reaction (GO:0060046)7.45945681
4meiotic cell cycle (GO:0051321)7.08323241
5positive regulation of humoral immune response (GO:0002922)7.00760891
6regulation of meiosis I (GO:0060631)6.99189167
7piRNA metabolic process (GO:0034587)6.91965520
8regulation of histone H3-K9 methylation (GO:0051570)6.47143870
9retinal cone cell development (GO:0046549)6.18718565
10oocyte development (GO:0048599)6.08566127
11multicellular organism reproduction (GO:0032504)6.04917133
12positive regulation of histone H3-K4 methylation (GO:0051571)5.87844824
13protein kinase C signaling (GO:0070528)5.76666143
14DNA methylation involved in gamete generation (GO:0043046)5.75996334
15negative regulation of histone methylation (GO:0031061)5.49677213
16female gamete generation (GO:0007292)5.47483423
17regulation of steroid hormone secretion (GO:2000831)5.01695951
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.01204118
19positive regulation of mitotic sister chromatid separation (GO:1901970)5.01204118
20positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.01204118
21negative regulation of reproductive process (GO:2000242)4.90367172
22regulation of cell maturation (GO:1903429)4.85039701
23mitotic chromosome condensation (GO:0007076)4.65776747
24gene silencing by RNA (GO:0031047)4.63290195
25glycine transport (GO:0015816)4.61924117
26negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.57138428
27negative regulation of execution phase of apoptosis (GO:1900118)4.47809601
28positive regulation of histone methylation (GO:0031062)4.16054210
29protein localization to kinetochore (GO:0034501)4.14754826
30negative regulation of cAMP-mediated signaling (GO:0043951)4.10136629
31positive regulation of chromosome segregation (GO:0051984)4.07827406
32protein localization to chromosome, centromeric region (GO:0071459)4.05728392
33establishment of chromosome localization (GO:0051303)4.04993296
34positive regulation of isotype switching (GO:0045830)4.00877591
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.00752976
36reproduction (GO:0000003)3.99086444
37centriole replication (GO:0007099)3.88574667
38regulation of retinoic acid receptor signaling pathway (GO:0048385)3.86794783
39positive regulation of gastrulation (GO:2000543)3.79280093
40mitotic metaphase plate congression (GO:0007080)3.78634845
41nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.75060138
42primitive streak formation (GO:0090009)3.73364559
43citrulline biosynthetic process (GO:0019240)3.68100154
44regulation of histone methylation (GO:0031060)3.67186375
45regulation of histone H3-K4 methylation (GO:0051569)3.64137540
46synapsis (GO:0007129)3.52681604
47male meiosis I (GO:0007141)3.52200248
48positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.48181092
49regulation of isotype switching to IgG isotypes (GO:0048302)3.47943209
50positive regulation of DNA recombination (GO:0045911)3.44400635
51DNA alkylation (GO:0006305)3.44239145
52DNA methylation (GO:0006306)3.44239145
53stress granule assembly (GO:0034063)3.42237907
54regulation of meiosis (GO:0040020)3.40549308
55synaptonemal complex assembly (GO:0007130)3.39091151
56positive regulation of uterine smooth muscle contraction (GO:0070474)3.35576023
57regulation of steroid hormone biosynthetic process (GO:0090030)3.30893283
58negative regulation of histone modification (GO:0031057)3.23677614
59gene silencing (GO:0016458)3.20989806
60regulation of hypersensitivity (GO:0002883)3.19568421
61protein localization to chromosome (GO:0034502)3.18534477
62tolerance induction (GO:0002507)3.17349649
63binding of sperm to zona pellucida (GO:0007339)3.16768985
64male meiosis (GO:0007140)3.15965197
65fertilization (GO:0009566)3.13816148
66regulation of chronic inflammatory response (GO:0002676)3.13102107
67chromosome organization involved in meiosis (GO:0070192)3.13020723
68regulation of isotype switching (GO:0045191)3.06222750
69negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.06091451
70oogenesis (GO:0048477)3.03149105
71metaphase plate congression (GO:0051310)3.02352827
72synaptonemal complex organization (GO:0070193)3.00279955
73regulation of interleukin-13 production (GO:0032656)3.00107353
74regulation of gamma-delta T cell differentiation (GO:0045586)2.99581381
75regulation of double-strand break repair via homologous recombination (GO:0010569)2.97344608
76CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.96892137
77negative thymic T cell selection (GO:0045060)2.96399716
78negative T cell selection (GO:0043383)2.95813450
79somite rostral/caudal axis specification (GO:0032525)2.94170584
80nucleus organization (GO:0006997)2.93975264
81meiotic nuclear division (GO:0007126)2.92535822
82positive regulation of reproductive process (GO:2000243)2.92427400
83CENP-A containing nucleosome assembly (GO:0034080)2.92246673
84centrosome duplication (GO:0051298)2.90558173
85phosphorelay signal transduction system (GO:0000160)2.89736674
86meiosis I (GO:0007127)2.89666398
87regulation of spindle checkpoint (GO:0090231)2.89476473
88N-terminal protein amino acid acetylation (GO:0006474)2.88361784
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87985732
90negative regulation of chromatin modification (GO:1903309)2.87200751
91positive regulation of immunoglobulin production (GO:0002639)2.84395969
92phosphatidylinositol dephosphorylation (GO:0046856)2.82516150
93positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80408181
94meiotic cell cycle process (GO:1903046)2.80135192
95regulation of meiotic cell cycle (GO:0051445)2.79285992
96L-amino acid import (GO:0043092)2.79214986
97regulation of chromatin silencing (GO:0031935)2.78749732
98attachment of spindle microtubules to kinetochore (GO:0008608)2.76577584
99labyrinthine layer development (GO:0060711)2.73542253
100DNA damage induced protein phosphorylation (GO:0006975)2.73095816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.37260357
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.26371418
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.48966485
4NOTCH1_21737748_ChIP-Seq_TLL_Human4.21523173
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.94740995
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.68338310
7E2F7_22180533_ChIP-Seq_HELA_Human3.50881849
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.01514188
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.96155460
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.96155460
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.96155460
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.58843912
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38723991
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36874781
15RUNX_20019798_ChIP-Seq_JUKART_Human2.21051043
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10265776
17EZH2_22144423_ChIP-Seq_EOC_Human12.3602292
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96233054
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81009534
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79775002
21MYB_26560356_Chip-Seq_TH2_Human1.51190722
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.49940745
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47170453
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46333149
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.41496970
26MYB_26560356_Chip-Seq_TH1_Human1.35341310
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33790102
28IRF1_19129219_ChIP-ChIP_H3396_Human1.30113759
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29623091
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.29083366
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28025267
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23026667
33PRDM14_20953172_ChIP-Seq_ESCs_Human1.20778218
34FOXP3_21729870_ChIP-Seq_TREG_Human1.20512411
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.17752581
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16506878
37VDR_23849224_ChIP-Seq_CD4+_Human1.11296863
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11230147
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10217190
40SMRT_27268052_Chip-Seq_Bcells_Human1.07864631
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07814026
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03068054
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01782111
44GATA3_26560356_Chip-Seq_TH1_Human0.98641333
45LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97429186
46YY1_21170310_ChIP-Seq_MESCs_Mouse0.96185374
47GATA3_27048872_Chip-Seq_THYMUS_Human0.95882049
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94466551
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92225908
50GBX2_23144817_ChIP-Seq_PC3_Human0.90530556
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90019525
52FOXO3_23340844_ChIP-Seq_DLD1_Human0.89100871
53NANOG_20526341_ChIP-Seq_ESCs_Human0.88790993
54EP300_21415370_ChIP-Seq_HL-1_Mouse0.85734892
55CBP_20019798_ChIP-Seq_JUKART_Human0.84675691
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84675691
57GATA3_26560356_Chip-Seq_TH2_Human0.83073337
58GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80224671
59GATA1_26923725_Chip-Seq_HPCs_Mouse0.79502426
60TCF4_23295773_ChIP-Seq_U87_Human0.79209656
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78894742
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78246337
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77303727
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.76213800
65SALL4_22934838_ChIP-ChIP_CD34+_Human0.76182026
66TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.72508062
67TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72488344
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72033894
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.71871687
70FOXM1_26456572_ChIP-Seq_MCF-7_Human0.71755411
71GF1_26923725_Chip-Seq_HPCs_Mouse0.71183950
72FOXH1_21741376_ChIP-Seq_EPCs_Human0.71126156
73KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70228913
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69196112
75SMAD4_21741376_ChIP-Seq_EPCs_Human0.69156323
76EST1_17652178_ChIP-ChIP_JURKAT_Human0.68471198
77UTX_26944678_Chip-Seq_JUKART_Human0.67648820
78MYC_18940864_ChIP-ChIP_HL60_Human0.66762939
79BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.66722197
80AR_21909140_ChIP-Seq_LNCAP_Human0.66692248
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.65687247
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.65670579
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.65529857
84KLF4_19829295_ChIP-Seq_ESCs_Human0.64987005
85STAT3_23295773_ChIP-Seq_U87_Human0.62694749
86GABP_17652178_ChIP-ChIP_JURKAT_Human0.62437314
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.61960999
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.60479029
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.57317569
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.57247750
91ELK4_26923725_Chip-Seq_MESODERM_Mouse0.55457057
92P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.55167799
93TOP2B_26459242_ChIP-Seq_MCF-7_Human0.54795493
94AR_25329375_ChIP-Seq_VCAP_Human0.54203824
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.53076753
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.52906190
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.52491678
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.52491678
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.52473871
100NANOG_18555785_ChIP-Seq_MESCs_Mouse0.51891319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.66532373
2MP0002138_abnormal_hepatobiliary_system4.52654792
3MP0008877_abnormal_DNA_methylation4.13172463
4MP0008789_abnormal_olfactory_epithelium3.72576907
5MP0006292_abnormal_olfactory_placode3.48345063
6MP0005394_taste/olfaction_phenotype3.32385727
7MP0005499_abnormal_olfactory_system3.32385727
8MP0002139_abnormal_hepatobiliary_system3.17255372
9MP0005395_other_phenotype3.06687598
10MP0008057_abnormal_DNA_replication2.92680232
11MP0001873_stomach_inflammation2.77586200
12MP0003890_abnormal_embryonic-extraembry2.64329957
13MP0003693_abnormal_embryo_hatching2.50544899
14MP0003699_abnormal_female_reproductive2.49870138
15MP0003183_abnormal_peptide_metabolism2.23141926
16MP0005360_urolithiasis2.21161094
17MP0003077_abnormal_cell_cycle2.04987759
18MP0010094_abnormal_chromosome_stability1.99048495
19MP0002234_abnormal_pharynx_morphology1.96905927
20MP0001929_abnormal_gametogenesis1.95979896
21MP0010030_abnormal_orbit_morphology1.87226266
22MP0002210_abnormal_sex_determination1.87208601
23MP0008058_abnormal_DNA_repair1.84992627
24MP0003763_abnormal_thymus_physiology1.84321851
25MP0010234_abnormal_vibrissa_follicle1.75241999
26MP0003252_abnormal_bile_duct1.74992646
27MP0009840_abnormal_foam_cell1.62163627
28MP0003111_abnormal_nucleus_morphology1.60988672
29MP0000685_abnormal_immune_system1.57974405
30MP0005410_abnormal_fertilization1.54322136
31MP0000653_abnormal_sex_gland1.48715563
32MP0001730_embryonic_growth_arrest1.47536796
33MP0002161_abnormal_fertility/fecundity1.46407519
34MP0001348_abnormal_lacrimal_gland1.44692666
35MP0003950_abnormal_plasma_membrane1.37027747
36MP0001119_abnormal_female_reproductive1.33925346
37MP0005671_abnormal_response_to1.29345720
38MP0010307_abnormal_tumor_latency1.29057622
39MP0003879_abnormal_hair_cell1.28852991
40MP0005310_abnormal_salivary_gland1.26967035
41MP0009333_abnormal_splenocyte_physiolog1.21902902
42MP0001800_abnormal_humoral_immune1.17295731
43MP0005647_abnormal_sex_gland1.16327134
44MP0002160_abnormal_reproductive_system1.13050803
45MP0001145_abnormal_male_reproductive1.12230552
46MP0000703_abnormal_thymus_morphology1.08906870
47MP0002396_abnormal_hematopoietic_system1.08292548
48MP0005389_reproductive_system_phenotype1.06059638
49MP0008995_early_reproductive_senescence1.04448852
50MP0000350_abnormal_cell_proliferation1.02402820
51MP0010368_abnormal_lymphatic_system1.02208444
52MP0002398_abnormal_bone_marrow1.02008641
53MP0002420_abnormal_adaptive_immunity0.94239793
54MP0005000_abnormal_immune_tolerance0.93077083
55MP0001819_abnormal_immune_cell0.91095377
56MP0003436_decreased_susceptibility_to0.89900415
57MP0001293_anophthalmia0.88566496
58MP0002723_abnormal_immune_serum0.86987457
59MP0000762_abnormal_tongue_morphology0.86600892
60MP0008932_abnormal_embryonic_tissue0.86013219
61MP0005646_abnormal_pituitary_gland0.85366357
62MP0002452_abnormal_antigen_presenting0.84963694
63MP0003698_abnormal_male_reproductive0.84808238
64MP0002163_abnormal_gland_morphology0.83781350
65MP0001666_abnormal_nutrient_absorption0.82697140
66MP0001790_abnormal_immune_system0.82395407
67MP0005387_immune_system_phenotype0.82395407
68MP0001672_abnormal_embryogenesis/_devel0.82050347
69MP0005380_embryogenesis_phenotype0.82050347
70MP0003786_premature_aging0.80954676
71MP0000678_abnormal_parathyroid_gland0.80162087
72MP0003868_abnormal_feces_composition0.79628685
73MP0001919_abnormal_reproductive_system0.79042980
74MP0000716_abnormal_immune_system0.78856198
75MP0004947_skin_inflammation0.78770385
76MP0004381_abnormal_hair_follicle0.78313507
77MP0000689_abnormal_spleen_morphology0.77765664
78MP0006082_CNS_inflammation0.77729934
79MP0003121_genomic_imprinting0.76604812
80MP0002722_abnormal_immune_system0.75733470
81MP0002019_abnormal_tumor_incidence0.75153655
82MP0004957_abnormal_blastocyst_morpholog0.74487837
83MP0000631_abnormal_neuroendocrine_gland0.74065969
84MP0000465_gastrointestinal_hemorrhage0.73894692
85MP0000427_abnormal_hair_cycle0.73337782
86MP0001984_abnormal_olfaction0.72276801
87MP0002006_tumorigenesis0.71235042
88MP0002254_reproductive_system_inflammat0.70150578
89MP0005085_abnormal_gallbladder_physiolo0.70020719
90MP0010678_abnormal_skin_adnexa0.68305465
91MP0005076_abnormal_cell_differentiation0.67312782
92MP0000566_synostosis0.64478656
93MP0002089_abnormal_postnatal_growth/wei0.64051727
94MP0001986_abnormal_taste_sensitivity0.60834502
95MP0003959_abnormal_lean_body0.59625119
96MP0002429_abnormal_blood_cell0.59112232
97MP0009785_altered_susceptibility_to0.58749474
98MP0002405_respiratory_system_inflammati0.58218386
99MP0010155_abnormal_intestine_physiology0.53068831
100MP0002928_abnormal_bile_duct0.52971127

Predicted human phenotypes

RankGene SetZ-score
1Supernumerary spleens (HP:0009799)5.64538591
2Abnormality of abdominal situs (HP:0011620)5.31643538
3Abdominal situs inversus (HP:0003363)5.31643538
4Facial hemangioma (HP:0000329)5.17721418
5Impulsivity (HP:0100710)4.86932858
6Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.79053866
7Cholecystitis (HP:0001082)4.48131445
8Abnormal gallbladder physiology (HP:0012438)4.48131445
9Hypoplasia of the fovea (HP:0007750)4.32610399
10Aplasia/Hypoplasia of the fovea (HP:0008060)4.32610399
11Lip pit (HP:0100267)4.03506456
12Hypophosphatemic rickets (HP:0004912)3.98853546
13Anterior segment dysgenesis (HP:0007700)3.91895072
14Oligodactyly (hands) (HP:0001180)3.67854026
15Osteomalacia (HP:0002749)3.63607341
16Abnormality of the fovea (HP:0000493)3.58422555
17Chromsome breakage (HP:0040012)3.44573190
18Male infertility (HP:0003251)3.41037885
19Capillary hemangiomas (HP:0005306)3.40999969
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.37108284
21Azoospermia (HP:0000027)3.30213035
22Septo-optic dysplasia (HP:0100842)3.22991897
23Infertility (HP:0000789)3.17933620
24Stomatitis (HP:0010280)3.14222268
25Malnutrition (HP:0004395)3.12784483
26Premature ovarian failure (HP:0008209)3.07318402
27Prostate neoplasm (HP:0100787)2.96332591
28Dysmetric saccades (HP:0000641)2.93440563
29Short tibia (HP:0005736)2.92273504
30Combined immunodeficiency (HP:0005387)2.90335914
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.85981122
32Absent septum pellucidum (HP:0001331)2.81669648
33Fair hair (HP:0002286)2.81492494
34Abnormality of the septum pellucidum (HP:0007375)2.76620069
35Gonadotropin excess (HP:0000837)2.74337537
36Hypokinesia (HP:0002375)2.73284511
37Aplasia/Hypoplasia of the macula (HP:0008059)2.71572061
38Dysdiadochokinesis (HP:0002075)2.70404773
39Papillary thyroid carcinoma (HP:0002895)2.69574014
40Median cleft lip (HP:0000161)2.62752050
41Oligodactyly (HP:0012165)2.58566006
42Wrist flexion contracture (HP:0001239)2.57820562
43Abnormal spermatogenesis (HP:0008669)2.55840597
44Stillbirth (HP:0003826)2.52696116
45Severe combined immunodeficiency (HP:0004430)2.52015966
46Anhidrosis (HP:0000970)2.51339864
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.50984450
48Apathy (HP:0000741)2.49239324
49Striae distensae (HP:0001065)2.48077897
50Aplasia/Hypoplasia affecting the retina (HP:0008061)2.47573713
51Abnormality of the labia minora (HP:0012880)2.39391074
52Hypercortisolism (HP:0001578)2.34704071
53Metaphyseal irregularity (HP:0003025)2.33789920
54Truncal obesity (HP:0001956)2.32863195
55Diminished motivation (HP:0000745)2.30829962
56Spinal cord compression (HP:0002176)2.29291442
57Urethral obstruction (HP:0000796)2.29169007
58IgG deficiency (HP:0004315)2.24746753
59Heterotopia (HP:0002282)2.20349169
60Enlarged penis (HP:0000040)2.18928470
61Lower limb hyperreflexia (HP:0002395)2.16586632
62Pustule (HP:0200039)2.15253861
63Impaired smooth pursuit (HP:0007772)2.15128834
64Posterior subcapsular cataract (HP:0007787)2.12492977
65Nephroblastoma (Wilms tumor) (HP:0002667)2.10114140
66Aplastic anemia (HP:0001915)2.08241399
67Abnormality of the phalanges of the hallux (HP:0010057)2.07986266
68Hypergonadotropic hypogonadism (HP:0000815)2.06388468
69Maternal diabetes (HP:0009800)2.05278571
70Generalized hypopigmentation of hair (HP:0011358)2.03332750
71Hypoplasia of the uterus (HP:0000013)2.02670541
72Skin pits (HP:0100276)1.99553376
73Congenital sensorineural hearing impairment (HP:0008527)1.98072047
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97283488
75T lymphocytopenia (HP:0005403)1.97262060
76IgA deficiency (HP:0002720)1.97256039
77Abnormality of chromosome segregation (HP:0002916)1.95846298
78Generalized aminoaciduria (HP:0002909)1.95264908
79Embryonal renal neoplasm (HP:0011794)1.94945326
80Cleft eyelid (HP:0000625)1.94518168
81Intrahepatic cholestasis (HP:0001406)1.93376133
82Abnormal biliary tract physiology (HP:0012439)1.86360370
83Bile duct proliferation (HP:0001408)1.86360370
84Abnormal lung lobation (HP:0002101)1.84424175
85Abnormality of the prostate (HP:0008775)1.81091784
86Limb hypertonia (HP:0002509)1.81022861
87Abnormality of T cell number (HP:0011839)1.78952215
88Muscle stiffness (HP:0003552)1.77805318
89Clubbing of toes (HP:0100760)1.76601305
90Gaze-evoked nystagmus (HP:0000640)1.73023030
91Peripheral hypomyelination (HP:0007182)1.72156140
92Abnormality of the preputium (HP:0100587)1.70700738
93Bicornuate uterus (HP:0000813)1.70495587
94Abnormality of chromosome stability (HP:0003220)1.70081843
95Cafe-au-lait spot (HP:0000957)1.69277608
96Abnormal foot bone ossification (HP:0010675)1.68855370
97Hyperactive renin-angiotensin system (HP:0000841)1.68682206
98Slow saccadic eye movements (HP:0000514)1.67411776
99Hypohidrosis (HP:0000966)1.67234512
100Conjunctival telangiectasia (HP:0000524)1.67171543

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.80011899
2MAP3K135.27743878
3ARAF4.53157024
4CDK123.42909703
5NEK63.19113070
6CDK93.06656421
7TAOK32.90327760
8STK242.74531299
9BRAF2.35811365
10TTK2.08837676
11PASK2.04309027
12TXK1.95654077
13MOS1.91840784
14AURKA1.83164954
15MAP3K141.83023144
16MELK1.81789834
17EIF2AK31.76052718
18CDK191.69347558
19MET1.67032766
20MAP4K11.62976079
21NTRK21.56544883
22PRKCI1.54439972
23KSR21.52139307
24CDK81.47119792
25RAF11.46613939
26MAP3K101.39546894
27CDK71.39434047
28CDC71.34623402
29BRD41.32367844
30CHUK1.17094828
31TNIK1.11959129
32STK31.11477969
33PIM11.11222960
34PRPF4B1.06347836
35ZAP701.04037526
36MARK31.02882887
37NUAK11.01926097
38NEK91.00766053
39ZAK1.00526162
40RIPK10.97096082
41MST40.96383748
42TNK20.94991933
43CAMKK10.88813020
44CHEK10.84506199
45CAMKK20.83443158
46ITK0.83429328
47IKBKB0.80906574
48IKBKE0.80565038
49PLK10.79940376
50MAP3K80.77974243
51KSR10.76469181
52TRIM280.72240038
53CDK20.70697330
54PBK0.67292988
55CDK40.64632821
56SRPK10.63042132
57LCK0.62748859
58CHEK20.62429599
59JAK30.59324465
60WNK10.59022199
61CSF1R0.58011140
62PDK10.56960150
63FES0.56879463
64CSNK1D0.55177060
65BUB10.54803752
66TGFBR10.54200289
67EEF2K0.54112667
68TYRO30.52784670
69ATM0.52015799
70AURKB0.50860797
71PRKCQ0.50058584
72TIE10.48329524
73BRSK10.46755266
74CSK0.46425164
75MTOR0.46134999
76ATR0.45631336
77NLK0.45002448
78MAP3K70.44880448
79MAPK110.44171286
80CDK10.39919287
81LATS10.39700413
82VRK10.39576294
83TEC0.35768509
84PRKG10.35761020
85STK40.35390371
86NEK20.35217025
87TRPM70.32888816
88MAPKAPK30.31299050
89MAPK10.29436575
90DMPK0.29369023
91OXSR10.28411800
92SIK20.26313741
93PAK10.26052074
94EGFR0.25182293
95EIF2AK20.25021245
96CSNK1E0.24476009
97PKN10.24431777
98RPS6KB20.22376977
99PTK20.22106619
100PLK30.20929362

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.20331513
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.03823633
3Cell cycle_Homo sapiens_hsa041103.74567237
4Primary immunodeficiency_Homo sapiens_hsa053402.71070684
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.60973968
6Caffeine metabolism_Homo sapiens_hsa002322.59702479
7Ovarian steroidogenesis_Homo sapiens_hsa049132.58034665
8RNA degradation_Homo sapiens_hsa030182.52179739
9T cell receptor signaling pathway_Homo sapiens_hsa046602.37707600
10Oocyte meiosis_Homo sapiens_hsa041142.30218858
11Mismatch repair_Homo sapiens_hsa034302.15857997
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.10669434
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91754457
14Dorso-ventral axis formation_Homo sapiens_hsa043201.88253399
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.80644330
16Homologous recombination_Homo sapiens_hsa034401.75536592
17Allograft rejection_Homo sapiens_hsa053301.68040320
18Autoimmune thyroid disease_Homo sapiens_hsa053201.66291540
19RNA transport_Homo sapiens_hsa030131.63400742
20Nucleotide excision repair_Homo sapiens_hsa034201.60585406
21Circadian rhythm_Homo sapiens_hsa047101.59575423
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.58191060
23p53 signaling pathway_Homo sapiens_hsa041151.57025306
24Base excision repair_Homo sapiens_hsa034101.55863827
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53022314
26Herpes simplex infection_Homo sapiens_hsa051681.44485839
27Fanconi anemia pathway_Homo sapiens_hsa034601.35105373
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.31307313
29Inositol phosphate metabolism_Homo sapiens_hsa005621.28995172
30Measles_Homo sapiens_hsa051621.27846393
31DNA replication_Homo sapiens_hsa030301.26719498
32Viral carcinogenesis_Homo sapiens_hsa052031.26626205
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24525389
34Asthma_Homo sapiens_hsa053101.22789205
35RNA polymerase_Homo sapiens_hsa030201.22134907
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20245380
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17198343
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16072439
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14177945
40Olfactory transduction_Homo sapiens_hsa047401.13602032
41mTOR signaling pathway_Homo sapiens_hsa041501.11948431
42Hematopoietic cell lineage_Homo sapiens_hsa046401.07405190
43mRNA surveillance pathway_Homo sapiens_hsa030151.07202132
44B cell receptor signaling pathway_Homo sapiens_hsa046621.06487371
45Thyroid cancer_Homo sapiens_hsa052161.05897253
46Folate biosynthesis_Homo sapiens_hsa007901.02449370
47HTLV-I infection_Homo sapiens_hsa051660.97873422
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.94106558
49FoxO signaling pathway_Homo sapiens_hsa040680.91951744
50Influenza A_Homo sapiens_hsa051640.87487585
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87414820
52Phototransduction_Homo sapiens_hsa047440.86090533
53TNF signaling pathway_Homo sapiens_hsa046680.85507230
54Small cell lung cancer_Homo sapiens_hsa052220.83230986
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82914791
56Hepatitis B_Homo sapiens_hsa051610.77334870
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76036804
58Acute myeloid leukemia_Homo sapiens_hsa052210.75761502
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74653735
60Pancreatic cancer_Homo sapiens_hsa052120.72164389
61Renal cell carcinoma_Homo sapiens_hsa052110.72020901
62Spliceosome_Homo sapiens_hsa030400.69969789
63Non-small cell lung cancer_Homo sapiens_hsa052230.67874977
64Epstein-Barr virus infection_Homo sapiens_hsa051690.67756648
65ABC transporters_Homo sapiens_hsa020100.65083950
66Chemokine signaling pathway_Homo sapiens_hsa040620.63804629
67Colorectal cancer_Homo sapiens_hsa052100.59963032
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58564326
69Osteoclast differentiation_Homo sapiens_hsa043800.58239437
70Gap junction_Homo sapiens_hsa045400.55981664
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50263875
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49637655
73Endometrial cancer_Homo sapiens_hsa052130.46929113
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44684556
75MicroRNAs in cancer_Homo sapiens_hsa052060.44352495
76Apoptosis_Homo sapiens_hsa042100.43266447
77TGF-beta signaling pathway_Homo sapiens_hsa043500.43055798
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42057288
79ErbB signaling pathway_Homo sapiens_hsa040120.41423844
80Graft-versus-host disease_Homo sapiens_hsa053320.39119134
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38679745
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.38317399
83Ras signaling pathway_Homo sapiens_hsa040140.38016150
84MAPK signaling pathway_Homo sapiens_hsa040100.37748508
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.37661688
86Vitamin digestion and absorption_Homo sapiens_hsa049770.36910694
87Purine metabolism_Homo sapiens_hsa002300.36398020
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36076162
89Prolactin signaling pathway_Homo sapiens_hsa049170.36026190
90Prostate cancer_Homo sapiens_hsa052150.33945825
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29474970
92HIF-1 signaling pathway_Homo sapiens_hsa040660.28981190
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28884212
94Toxoplasmosis_Homo sapiens_hsa051450.26747159
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25038587
96Shigellosis_Homo sapiens_hsa051310.22526301
97Morphine addiction_Homo sapiens_hsa050320.22432470
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22134817
99Hepatitis C_Homo sapiens_hsa051600.20917328
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.17940203

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