FAM169B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.90404619
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.43152708
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.43152708
4righting reflex (GO:0060013)6.19396379
5detection of chemical stimulus involved in sensory perception of smell (GO:0050911)6.14798763
6negative T cell selection (GO:0043383)6.13515452
7protein K11-linked deubiquitination (GO:0035871)5.98481133
8regulation of gamma-delta T cell differentiation (GO:0045586)5.94106207
9antigen processing and presentation of endogenous antigen (GO:0019883)5.77040028
10negative thymic T cell selection (GO:0045060)5.67724063
11regulation of gamma-delta T cell activation (GO:0046643)5.60917843
12dendritic spine morphogenesis (GO:0060997)5.41998123
13indolalkylamine metabolic process (GO:0006586)5.34364579
14positive T cell selection (GO:0043368)5.30172206
15reflex (GO:0060004)5.28323492
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.22733498
17positive thymic T cell selection (GO:0045059)5.11112019
18T cell selection (GO:0045058)4.75239461
19regulation of sarcomere organization (GO:0060297)4.71131634
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.70929271
21negative regulation of T-helper cell differentiation (GO:0045623)4.68208811
22negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.68208811
23thymic T cell selection (GO:0045061)4.63593634
24response to interleukin-15 (GO:0070672)4.63045682
25neural tube formation (GO:0001841)4.61230737
26interferon-gamma production (GO:0032609)4.59113033
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.40668074
28cellular response to interleukin-15 (GO:0071350)4.32645906
29detection of chemical stimulus involved in sensory perception (GO:0050907)4.26388652
30detection of light stimulus involved in visual perception (GO:0050908)4.26062103
31detection of light stimulus involved in sensory perception (GO:0050962)4.26062103
32tooth mineralization (GO:0034505)4.24776369
33regulation of isotype switching to IgG isotypes (GO:0048302)4.18280402
34positive regulation of humoral immune response (GO:0002922)4.15053134
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.12595175
36vocalization behavior (GO:0071625)4.11730037
37T cell receptor signaling pathway (GO:0050852)4.04851343
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.02784194
39tachykinin receptor signaling pathway (GO:0007217)4.02450003
40regulation of T cell tolerance induction (GO:0002664)3.98831348
41seminiferous tubule development (GO:0072520)3.92943261
42negative regulation of cell killing (GO:0031342)3.92916258
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92916258
44chemosensory behavior (GO:0007635)3.91537867
45cilium or flagellum-dependent cell motility (GO:0001539)3.87302828
46indole-containing compound metabolic process (GO:0042430)3.86642225
47phosphatidylinositol acyl-chain remodeling (GO:0036149)3.81354097
48negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.79592672
49NAD biosynthetic process (GO:0009435)3.76302848
50T cell costimulation (GO:0031295)3.75174228
51leukocyte aggregation (GO:0070486)3.73389612
52regulation of T-helper 1 cell differentiation (GO:0045625)3.73076243
53T cell migration (GO:0072678)3.70150404
54lymphocyte costimulation (GO:0031294)3.69273843
55regulation of alpha-beta T cell proliferation (GO:0046640)3.66446884
56response to misfolded protein (GO:0051788)3.65027432
57enteric nervous system development (GO:0048484)3.64879224
58tryptophan catabolic process (GO:0006569)3.63404663
59indole-containing compound catabolic process (GO:0042436)3.63404663
60indolalkylamine catabolic process (GO:0046218)3.63404663
61regulation of female gonad development (GO:2000194)3.61116391
62antigen receptor-mediated signaling pathway (GO:0050851)3.60112038
63regulation of interleukin-12 biosynthetic process (GO:0045075)3.59616619
64aromatic amino acid family catabolic process (GO:0009074)3.56361221
65regulation of B cell receptor signaling pathway (GO:0050855)3.55795811
66glycine transport (GO:0015816)3.53634243
67regulation of interleukin-2 biosynthetic process (GO:0045076)3.53533194
68positive regulation of interleukin-2 production (GO:0032743)3.51340901
69nucleoside diphosphate catabolic process (GO:0009134)3.47788693
70L-phenylalanine catabolic process (GO:0006559)3.47698088
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.47698088
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.47560807
73negative regulation of actin filament bundle assembly (GO:0032232)3.44983207
74negative regulation of translation, ncRNA-mediated (GO:0040033)3.44524656
75regulation of translation, ncRNA-mediated (GO:0045974)3.44524656
76negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.44524656
77negative regulation of alpha-beta T cell differentiation (GO:0046639)3.44119435
78protein localization to synapse (GO:0035418)3.42487764
79regulation of T cell receptor signaling pathway (GO:0050856)3.42160878
80monoubiquitinated protein deubiquitination (GO:0035520)3.41179859
81detection of chemical stimulus (GO:0009593)3.40414992
82negative regulation of cytosolic calcium ion concentration (GO:0051481)3.38778642
83regulation of regulatory T cell differentiation (GO:0045589)3.38647311
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.36741907
85gamma-aminobutyric acid transport (GO:0015812)3.36003389
86positive regulation of protein sumoylation (GO:0033235)3.35758359
87tryptophan metabolic process (GO:0006568)3.35684352
88serotonin metabolic process (GO:0042428)3.32142077
89L-phenylalanine metabolic process (GO:0006558)3.31283594
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.31283594
91kynurenine metabolic process (GO:0070189)3.30787086
92V(D)J recombination (GO:0033151)3.30206022
93positive regulation of alpha-beta T cell proliferation (GO:0046641)3.28747160
94signal peptide processing (GO:0006465)3.27943856
95regulation of T-helper 2 cell differentiation (GO:0045628)3.23546286
96tolerance induction (GO:0002507)3.22815831
97prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.22576823
98regulation of glutamate receptor signaling pathway (GO:1900449)3.15253858
99positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.14277592
100activation of protein kinase A activity (GO:0034199)3.10526419
101cellular biogenic amine catabolic process (GO:0042402)3.09215666
102amine catabolic process (GO:0009310)3.09215666
103NIK/NF-kappaB signaling (GO:0038061)3.07468023
104alpha-beta T cell activation (GO:0046631)3.06809603
105cellular potassium ion transport (GO:0071804)3.05282616
106potassium ion transmembrane transport (GO:0071805)3.05282616
107proline transport (GO:0015824)3.02946494
108phosphatidylserine acyl-chain remodeling (GO:0036150)3.01632801
109activated T cell proliferation (GO:0050798)3.01111317
110positive regulation of isotype switching (GO:0045830)3.00253753
111positive regulation of T-helper 1 type immune response (GO:0002827)3.00222063
112gonadal mesoderm development (GO:0007506)2.99703188
113regulation of response to interferon-gamma (GO:0060330)2.99583746
114alpha-beta T cell differentiation (GO:0046632)2.98341380
115primary amino compound metabolic process (GO:1901160)2.98252321
116positive regulation of immunoglobulin production (GO:0002639)2.97367209
117triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.95351761
118behavioral response to nicotine (GO:0035095)2.94892427
119positive regulation of immunoglobulin mediated immune response (GO:0002891)2.94785954
120positive regulation of B cell mediated immunity (GO:0002714)2.94785954
121cAMP biosynthetic process (GO:0006171)2.93824252
122T cell differentiation (GO:0030217)2.92693115
123regulation of cAMP-mediated signaling (GO:0043949)2.92415751
124urea cycle (GO:0000050)2.91693042
125urea metabolic process (GO:0019627)2.91693042
126protein localization to cilium (GO:0061512)2.91613302
127regulation of B cell differentiation (GO:0045577)2.90706063
128synaptic transmission, dopaminergic (GO:0001963)2.90005810
129positive regulation of tolerance induction (GO:0002645)2.89376442
130CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.88220398
131T-helper cell differentiation (GO:0042093)2.88220398
132B cell receptor signaling pathway (GO:0050853)2.86739215
133regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.85707508
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.83603082
135negative regulation of calcium ion transport into cytosol (GO:0010523)2.83462422
136positive regulation of B cell differentiation (GO:0045579)2.83097848
137T cell homeostasis (GO:0043029)2.82161775
138positive regulation of steroid hormone secretion (GO:2000833)2.82048753
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.81875652
140regulation of tolerance induction (GO:0002643)2.81089510
141behavioral response to ethanol (GO:0048149)2.80586897
142phospholipid efflux (GO:0033700)2.79889246
143regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.78090896
144regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.78090896
145regulation of immunoglobulin production (GO:0002637)2.76401262
146protein K48-linked deubiquitination (GO:0071108)2.76092489
147positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.75276904
148potassium ion transport (GO:0006813)2.75116149
149positive regulation of DNA recombination (GO:0045911)2.74875759
150valine metabolic process (GO:0006573)2.73883490
151auditory receptor cell stereocilium organization (GO:0060088)2.73752415
152high-density lipoprotein particle remodeling (GO:0034375)2.73531909
153cell wall macromolecule metabolic process (GO:0044036)2.73423453
154phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.72691304
155adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.72261077
156serine family amino acid catabolic process (GO:0009071)2.72230535
157response to pheromone (GO:0019236)2.71490708
158regulation of isotype switching (GO:0045191)2.71483401
159drug transmembrane transport (GO:0006855)2.71457096
160embryonic epithelial tube formation (GO:0001838)2.70931227
161photoreceptor cell maintenance (GO:0045494)2.70874065
162regulation of immunoglobulin mediated immune response (GO:0002889)2.70817520
163pyridine nucleotide biosynthetic process (GO:0019363)2.70666434
164nicotinamide nucleotide biosynthetic process (GO:0019359)2.70666434
165negative regulation of sterol transport (GO:0032372)2.70400556
166negative regulation of cholesterol transport (GO:0032375)2.70400556
167cAMP metabolic process (GO:0046058)2.70019355
168drug catabolic process (GO:0042737)2.69376745
169negative regulation of type 2 immune response (GO:0002829)2.68243037
170hepatocyte apoptotic process (GO:0097284)2.68237807
171response to type I interferon (GO:0034340)2.67712835
172regulation of interleukin-2 production (GO:0032663)2.67370050
173regulation of neurotransmitter uptake (GO:0051580)2.66743254
174glycine metabolic process (GO:0006544)2.66635142
175aromatic amino acid family metabolic process (GO:0009072)2.66386587
176regulation of B cell mediated immunity (GO:0002712)2.66150946
177T cell activation (GO:0042110)2.62894142
178mast cell activation (GO:0045576)2.62360789
179cellular ketone body metabolic process (GO:0046950)2.61708390
180adaptation of signaling pathway (GO:0023058)2.61558838
181positive regulation of membrane potential (GO:0045838)2.60742957
182T cell differentiation involved in immune response (GO:0002292)2.60609124
183alpha-beta T cell differentiation involved in immune response (GO:0002293)2.60609124
184alpha-beta T cell activation involved in immune response (GO:0002287)2.60609124
185lymphocyte homeostasis (GO:0002260)2.60536293
186icosanoid secretion (GO:0032309)2.60456679
187arachidonic acid secretion (GO:0050482)2.60456679
188cellular response to type I interferon (GO:0071357)2.59549580
189type I interferon signaling pathway (GO:0060337)2.59549580
190positive regulation of RNA splicing (GO:0033120)2.59465253
191bile acid biosynthetic process (GO:0006699)2.59325052
192negative regulation of systemic arterial blood pressure (GO:0003085)2.59261029
193nitrogen cycle metabolic process (GO:0071941)2.57324737
194negative regulation of T cell mediated immunity (GO:0002710)2.55685960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.03366430
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.61944634
3EZH2_22144423_ChIP-Seq_EOC_Human4.33976311
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.31735346
5E2F7_22180533_ChIP-Seq_HELA_Human4.21511427
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.95726888
7VDR_22108803_ChIP-Seq_LS180_Human3.82619689
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.82570640
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.62132583
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.21600100
11* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.12751221
12MYC_22102868_ChIP-Seq_BL_Human3.02904130
13IGF1R_20145208_ChIP-Seq_DFB_Human2.96865658
14AR_21572438_ChIP-Seq_LNCaP_Human2.95948649
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.85500021
16RUNX_20019798_ChIP-Seq_JUKART_Human2.82234411
17* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.74970253
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73639508
19* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.70037454
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.68943365
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60757416
22ZNF274_21170338_ChIP-Seq_K562_Hela2.60202954
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.59405300
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.54285092
25MYB_26560356_Chip-Seq_TH2_Human2.53528807
26GBX2_23144817_ChIP-Seq_PC3_Human2.53038829
27* DROSHA_22980978_ChIP-Seq_HELA_Human2.49776654
28IRF8_21731497_ChIP-ChIP_J774_Mouse2.40786117
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38790937
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37813730
31CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36292508
32MYB_26560356_Chip-Seq_TH1_Human2.32756763
33MAF_26560356_Chip-Seq_TH1_Human2.31181884
34EGR1_19374776_ChIP-ChIP_THP-1_Human2.29356800
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25878146
36NOTCH1_21737748_ChIP-Seq_TLL_Human2.21800118
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.20900847
38CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17830067
39ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15047921
40UTX_26944678_Chip-Seq_JUKART_Human2.08885405
41* LXR_22158963_ChIP-Seq_LIVER_Mouse2.08486414
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07099233
43BP1_19119308_ChIP-ChIP_Hs578T_Human2.00195072
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99624571
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.99624571
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97168506
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.89020355
48BCAT_22108803_ChIP-Seq_LS180_Human1.87481750
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87011290
50* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78499103
51VDR_21846776_ChIP-Seq_THP-1_Human1.78388539
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.76346872
53STAT3_23295773_ChIP-Seq_U87_Human1.74485984
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73941540
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69602084
56MAF_26560356_Chip-Seq_TH2_Human1.67592198
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65781537
58ER_23166858_ChIP-Seq_MCF-7_Human1.65610323
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64691019
60P300_19829295_ChIP-Seq_ESCs_Human1.64682494
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63507656
62SMAD4_21799915_ChIP-Seq_A2780_Human1.61427227
63GATA3_27048872_Chip-Seq_THYMUS_Human1.60665347
64* REST_21632747_ChIP-Seq_MESCs_Mouse1.56381872
65SCL_19346495_ChIP-Seq_HPC-7_Human1.55946539
66SPI1_23547873_ChIP-Seq_NB4_Human1.51852023
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51124892
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.49606064
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49531384
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49408024
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48751656
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.48521490
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48496878
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48344434
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.47607690
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47051454
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.45413956
78TP53_16413492_ChIP-PET_HCT116_Human1.45359822
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45260657
80* TCF4_23295773_ChIP-Seq_U87_Human1.44966788
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43857503
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42777317
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41752667
84RNF2_27304074_Chip-Seq_NSC_Mouse1.40739568
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40617457
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40243080
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.39794508
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39569527
89CBP_20019798_ChIP-Seq_JUKART_Human1.39569527
90TCF4_22108803_ChIP-Seq_LS180_Human1.37695490
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35797775
92* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34993223
93FOXP3_21729870_ChIP-Seq_TREG_Human1.33762479
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33669365
95TCF7_22412390_ChIP-Seq_EML_Mouse1.32583328
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.31756441
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30560616
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30501794
99AR_25329375_ChIP-Seq_VCAP_Human1.30242726
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29896842
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29039565
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28642159
103FUS_26573619_Chip-Seq_HEK293_Human1.28387269
104JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27474214
105CIITA_25753668_ChIP-Seq_RAJI_Human1.26836193
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24336242
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23954611
108* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23329227
109VDR_23849224_ChIP-Seq_CD4+_Human1.22915150
110E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22643449
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22493427
112* SMAD4_21741376_ChIP-Seq_EPCs_Human1.22266060
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.21982146
114VDR_24763502_ChIP-Seq_THP-1_Human1.21765860
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21631798
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21278122
117SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19302253
118EZH2_27304074_Chip-Seq_ESCs_Mouse1.18854202
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15952289
120PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15780520
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15628360
122PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15263275
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14345591
124NANOG_19829295_ChIP-Seq_ESCs_Human1.14249539
125SOX2_19829295_ChIP-Seq_ESCs_Human1.14249539
126STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13844895
127TAF15_26573619_Chip-Seq_HEK293_Human1.11420055
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.10091204
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10024056
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09578084
131SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09031214
132RXR_22108803_ChIP-Seq_LS180_Human1.08789897
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08486442
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08152618
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07191162
136ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06954201
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05761182
138RNF2_27304074_Chip-Seq_ESCs_Mouse1.05748036
139ARNT_22903824_ChIP-Seq_MCF-7_Human1.05616023
140PU_27001747_Chip-Seq_BMDM_Mouse1.05203996
141TBL1_22424771_ChIP-Seq_293T_Human1.04921507
142* RUNX2_22187159_ChIP-Seq_PCA_Human1.04468673
143EWS_26573619_Chip-Seq_HEK293_Human1.04453299
144EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04208298
145EZH2_27294783_Chip-Seq_ESCs_Mouse1.03951778
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03327426
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03238596
148NFE2_27457419_Chip-Seq_LIVER_Mouse1.02718317
149EZH2_27294783_Chip-Seq_NPCs_Mouse1.01909599
150VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01581726
151KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01189431
152GATA3_26560356_Chip-Seq_TH2_Human1.00999088
153EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00765085
154TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.00657735
155FLI1_21867929_ChIP-Seq_TH2_Mouse1.00371646
156HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99961933
157PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99958667
158RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99758200
159* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99724800
160* CDX2_22108803_ChIP-Seq_LS180_Human0.99309051
161SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99237079
162REST_18959480_ChIP-ChIP_MESCs_Mouse0.99123310
163* FOXA1_25329375_ChIP-Seq_VCAP_Human0.99012215
164* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99012215
165* SMAD3_21741376_ChIP-Seq_HESCs_Human0.98878130
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98665758
167SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97984097
168CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97459749
169* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96860091
170* KDM2B_26808549_Chip-Seq_REH_Human0.96505232
171LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96185002
172NFYA_21822215_ChIP-Seq_K562_Human0.96086148
173KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95850444
174FOXM1_23109430_ChIP-Seq_U2OS_Human0.94862489
175SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94832703
176GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93259711
177NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91306128
178* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90565440
179GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88563117
180CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87286733
181LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87210414
182FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85128907
183FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.84665272
184NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84593177
185TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83746195
186GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83729738
187KDM2B_26808549_Chip-Seq_DND41_Human0.83301970
188CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83127965
189KDM5A_27292631_Chip-Seq_BREAST_Human0.82010819
190EST1_17652178_ChIP-ChIP_JURKAT_Human0.80539308
191SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79843424
192SPI1_23127762_ChIP-Seq_K562_Human0.78050769
193TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75443554
194GABP_17652178_ChIP-ChIP_JURKAT_Human0.74508911
195CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73396624
196GATA1_19941827_ChIP-Seq_MEL_Mouse0.70161581
197E2F1_21310950_ChIP-Seq_MCF-7_Human0.69231664
198TP63_19390658_ChIP-ChIP_HaCaT_Human0.68653310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo4.72274267
2MP0003763_abnormal_thymus_physiology4.36657098
3MP0001501_abnormal_sleep_pattern3.87605698
4MP0005360_urolithiasis3.57685704
5MP0002139_abnormal_hepatobiliary_system3.38812239
6MP0001835_abnormal_antigen_presentation3.32178728
7MP0000685_abnormal_immune_system3.26886473
8MP0005671_abnormal_response_to3.24094641
9MP0008961_abnormal_basal_metabolism3.19163135
10MP0005365_abnormal_bile_salt2.99976358
11MP0001800_abnormal_humoral_immune2.92723634
12MP0005085_abnormal_gallbladder_physiolo2.80589599
13MP0001790_abnormal_immune_system2.76336520
14MP0005387_immune_system_phenotype2.76336520
15MP0005377_hearing/vestibular/ear_phenot2.64944154
16MP0003878_abnormal_ear_physiology2.64944154
17MP0002822_catalepsy2.43059196
18MP0002398_abnormal_bone_marrow2.34127314
19MP0002723_abnormal_immune_serum2.34078185
20MP0005000_abnormal_immune_tolerance2.29064551
21MP0002166_altered_tumor_susceptibility2.28689849
22MP0002420_abnormal_adaptive_immunity2.26499644
23MP0009785_altered_susceptibility_to2.24296090
24MP0001819_abnormal_immune_cell2.23464857
25MP0002452_abnormal_antigen_presenting2.23274502
26MP0009745_abnormal_behavioral_response2.20849515
27MP0009333_abnormal_splenocyte_physiolog2.17818998
28MP0001905_abnormal_dopamine_level2.14904544
29MP0003436_decreased_susceptibility_to2.14829712
30MP0001968_abnormal_touch/_nociception2.13558509
31MP0008872_abnormal_physiological_respon2.11530504
32MP0000716_abnormal_immune_system2.10145144
33MP0005670_abnormal_white_adipose2.09888593
34MP0005025_abnormal_response_to2.08251060
35MP0008875_abnormal_xenobiotic_pharmacok2.06624382
36MP0005423_abnormal_somatic_nervous2.06054339
37MP0000703_abnormal_thymus_morphology2.04620640
38MP0004130_abnormal_muscle_cell2.04275616
39MP0005551_abnormal_eye_electrophysiolog2.00491830
40MP0003646_muscle_fatigue1.97459289
41MP0000689_abnormal_spleen_morphology1.97293077
42MP0002396_abnormal_hematopoietic_system1.97204283
43MP0009046_muscle_twitch1.95132676
44MP0002722_abnormal_immune_system1.92255312
45MP0003252_abnormal_bile_duct1.90489724
46MP0001873_stomach_inflammation1.89766330
47MP0002572_abnormal_emotion/affect_behav1.88299897
48MP0002006_tumorigenesis1.85925772
49MP0004381_abnormal_hair_follicle1.84924145
50MP0010155_abnormal_intestine_physiology1.80782412
51MP0002138_abnormal_hepatobiliary_system1.80275244
52MP0002405_respiratory_system_inflammati1.79542003
53MP0002735_abnormal_chemical_nociception1.79297709
54MP0004043_abnormal_pH_regulation1.75745484
55MP0009840_abnormal_foam_cell1.74276411
56MP0006276_abnormal_autonomic_nervous1.73265538
57MP0002429_abnormal_blood_cell1.72830128
58MP0006082_CNS_inflammation1.66164224
59MP0004947_skin_inflammation1.64034822
60MP0002736_abnormal_nociception_after1.63594668
61MP0003806_abnormal_nucleotide_metabolis1.62858995
62MP0001486_abnormal_startle_reflex1.62777347
63MP0001440_abnormal_grooming_behavior1.62330382
64MP0001853_heart_inflammation1.62171250
65MP0002419_abnormal_innate_immunity1.61699442
66MP0002148_abnormal_hypersensitivity_rea1.60930908
67MP0005645_abnormal_hypothalamus_physiol1.60009380
68MP0005646_abnormal_pituitary_gland1.59882753
69MP0004142_abnormal_muscle_tone1.59246334
70MP0001845_abnormal_inflammatory_respons1.57716047
71MP0000569_abnormal_digit_pigmentation1.57663002
72MP0000609_abnormal_liver_physiology1.56631019
73MP0003724_increased_susceptibility_to1.56528514
74MP0001485_abnormal_pinna_reflex1.56518858
75MP0003300_gastrointestinal_ulcer1.54979144
76MP0005464_abnormal_platelet_physiology1.54949614
77MP0003880_abnormal_central_pattern1.54305536
78MP0001348_abnormal_lacrimal_gland1.51436018
79MP0005075_abnormal_melanosome_morpholog1.48732829
80MP0003866_abnormal_defecation1.48134694
81MP0002733_abnormal_thermal_nociception1.48074601
82MP0003136_yellow_coat_color1.45114058
83MP0002132_abnormal_respiratory_system1.42048913
84MP0003635_abnormal_synaptic_transmissio1.41965663
85MP0003718_maternal_effect1.41780203
86MP0005448_abnormal_energy_balance1.40672718
87MP0003943_abnormal_hepatobiliary_system1.40627242
88MP0001970_abnormal_pain_threshold1.38884470
89MP0010329_abnormal_lipoprotein_level1.37784228
90MP0008057_abnormal_DNA_replication1.37059471
91MP0002933_joint_inflammation1.35956864
92MP0008469_abnormal_protein_level1.34890406
93MP0004133_heterotaxia1.31335522
94MP0002557_abnormal_social/conspecific_i1.27050839
95MP0002272_abnormal_nervous_system1.24824649
96MP0002064_seizures1.23533640
97MP0003183_abnormal_peptide_metabolism1.22102532
98MP0006072_abnormal_retinal_apoptosis1.21648461
99MP0003191_abnormal_cellular_cholesterol1.21145298
100MP0009764_decreased_sensitivity_to1.19293339
101MP0000372_irregular_coat_pigmentation1.18600849
102MP0002909_abnormal_adrenal_gland1.16271018
103MP0005253_abnormal_eye_physiology1.14934914
104MP0003868_abnormal_feces_composition1.13920421
105MP0001666_abnormal_nutrient_absorption1.12181015
106MP0002693_abnormal_pancreas_physiology1.10693863
107MP0001764_abnormal_homeostasis1.10558356
108MP0005220_abnormal_exocrine_pancreas1.10493068
109MP0003045_fibrosis1.10181560
110MP0002751_abnormal_autonomic_nervous1.06885703
111MP0002067_abnormal_sensory_capabilities1.06855292
112MP0010386_abnormal_urinary_bladder1.06348782
113MP0004147_increased_porphyrin_level1.06116268
114MP0000470_abnormal_stomach_morphology1.05778174
115MP0009763_increased_sensitivity_to1.05448917
116MP0001986_abnormal_taste_sensitivity1.05183360
117MP0005083_abnormal_biliary_tract1.04043679
118MP0005451_abnormal_body_composition1.03897908
119MP0001963_abnormal_hearing_physiology1.03835876
120MP0005332_abnormal_amino_acid1.02437744
121MP0004808_abnormal_hematopoietic_stem1.02127547
122MP0000631_abnormal_neuroendocrine_gland1.01628467
123MP0002876_abnormal_thyroid_physiology1.01309522
124MP0005167_abnormal_blood-brain_barrier0.99567866
125MP0005397_hematopoietic_system_phenotyp0.99330975
126MP0001545_abnormal_hematopoietic_system0.99330975
127MP0006292_abnormal_olfactory_placode0.98380043
128MP0003879_abnormal_hair_cell0.98334664
129MP0009765_abnormal_xenobiotic_induced0.98152289
130MP0002734_abnormal_mechanical_nocicepti0.97655011
131MP0004885_abnormal_endolymph0.97374585
132MP0000490_abnormal_crypts_of0.96497671
133MP0003303_peritoneal_inflammation0.94718016
134MP0005310_abnormal_salivary_gland0.93836768
135MP0001529_abnormal_vocalization0.93276811
136MP0008058_abnormal_DNA_repair0.93094339
137MP0002653_abnormal_ependyma_morphology0.92925206
138MP0001984_abnormal_olfaction0.92706553
139MP0010094_abnormal_chromosome_stability0.92541183
140MP0002063_abnormal_learning/memory/cond0.91635557
141MP0002019_abnormal_tumor_incidence0.91015848
142MP0005410_abnormal_fertilization0.90461133
143MP0000598_abnormal_liver_morphology0.89815932
144MP0002234_abnormal_pharynx_morphology0.88471400
145MP0001765_abnormal_ion_homeostasis0.85340632
146MP0004510_myositis0.84746894
147MP0000465_gastrointestinal_hemorrhage0.84569786
148MP0002229_neurodegeneration0.84550612
149MP0009697_abnormal_copulation0.84339554
150MP0000858_altered_metastatic_potential0.84250580
151MP0005319_abnormal_enzyme/_coenzyme0.84177011
152MP0005171_absent_coat_pigmentation0.83224785
153MP0004742_abnormal_vestibular_system0.82163265
154MP0000230_abnormal_systemic_arterial0.82079551
155MP0003693_abnormal_embryo_hatching0.81806778
156MP0005395_other_phenotype0.81713263
157MP0001944_abnormal_pancreas_morphology0.80893839
158MP0000026_abnormal_inner_ear0.79125905
159MP0003953_abnormal_hormone_level0.77918978
160MP0005584_abnormal_enzyme/coenzyme_acti0.77510546
161MP0002078_abnormal_glucose_homeostasis0.76251722
162MP0003633_abnormal_nervous_system0.75281845
163MP0002752_abnormal_somatic_nervous0.74856534
164MP0004019_abnormal_vitamin_homeostasis0.73984789
165MP0003077_abnormal_cell_cycle0.73408139
166MP0009643_abnormal_urine_homeostasis0.72325406
167MP0005386_behavior/neurological_phenoty0.71805077
168MP0004924_abnormal_behavior0.71805077
169MP0000639_abnormal_adrenal_gland0.71622728
170MP0002136_abnormal_kidney_physiology0.71196172
171MP0003950_abnormal_plasma_membrane0.70781825
172MP0004264_abnormal_extraembryonic_tissu0.69912254
173MP0002118_abnormal_lipid_homeostasis0.69688584
174MP0008569_lethality_at_weaning0.68781489
175MP0000427_abnormal_hair_cycle0.68458100
176MP0002102_abnormal_ear_morphology0.68215203
177MP0005266_abnormal_metabolism0.68037910
178MP0002928_abnormal_bile_duct0.65223262
179MP0003195_calcinosis0.65061645
180MP0005174_abnormal_tail_pigmentation0.64753578
181MP0001533_abnormal_skeleton_physiology0.63931494
182MP0009278_abnormal_bone_marrow0.63595026
183MP0005647_abnormal_sex_gland0.62382902
184MP0002009_preneoplasia0.61931463
185MP0001243_abnormal_dermal_layer0.58759610
186MP0009642_abnormal_blood_homeostasis0.57023305
187MP0003186_abnormal_redox_activity0.56090969
188MP0003448_altered_tumor_morphology0.53448258
189MP0003453_abnormal_keratinocyte_physiol0.51310249
190MP0000477_abnormal_intestine_morphology0.50338464

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.08160603
2Genetic anticipation (HP:0003743)5.98352053
3Abnormality of T cell number (HP:0011839)5.97177732
4Progressive cerebellar ataxia (HP:0002073)4.61811972
5Recurrent viral infections (HP:0004429)4.58459715
6Panhypogammaglobulinemia (HP:0003139)4.54164646
7Abnormality of T cells (HP:0002843)4.49611912
8Decreased central vision (HP:0007663)4.48523160
9Congenital stationary night blindness (HP:0007642)4.34519720
10Recurrent bronchitis (HP:0002837)4.29780205
11Abnormality of B cell number (HP:0010975)4.24745089
12B lymphocytopenia (HP:0010976)4.24745089
13Recurrent fungal infections (HP:0002841)4.16948789
14Severe combined immunodeficiency (HP:0004430)4.10669406
15Abnormal delayed hypersensitivity skin test (HP:0002963)4.05181394
16Chronic otitis media (HP:0000389)4.04917476
17Combined immunodeficiency (HP:0005387)4.03935575
18Retinal dysplasia (HP:0007973)3.76619359
19IgG deficiency (HP:0004315)3.75442116
20Elevated erythrocyte sedimentation rate (HP:0003565)3.68897897
21Abnormality of binocular vision (HP:0011514)3.58854786
22Diplopia (HP:0000651)3.58854786
23Gaze-evoked nystagmus (HP:0000640)3.58613051
24Eosinophilia (HP:0001880)3.58165122
25Chronic mucocutaneous candidiasis (HP:0002728)3.57761080
26Recurrent cutaneous fungal infections (HP:0011370)3.57761080
27IgM deficiency (HP:0002850)3.56941743
28Polyuria (HP:0000103)3.51425830
29Abnormality of aromatic amino acid family metabolism (HP:0004338)3.47107457
30Amelogenesis imperfecta (HP:0000705)3.44340744
31Joint swelling (HP:0001386)3.43940811
32Hypobetalipoproteinemia (HP:0003563)3.39191966
33Attenuation of retinal blood vessels (HP:0007843)3.39033014
34Hyperventilation (HP:0002883)3.36668170
35Molar tooth sign on MRI (HP:0002419)3.34813083
36Abnormality of midbrain morphology (HP:0002418)3.34813083
37Nasal polyposis (HP:0100582)3.31796058
38Chronic diarrhea (HP:0002028)3.30745792
39Recurrent sinusitis (HP:0011108)3.29301605
40Pustule (HP:0200039)3.25339314
41Agammaglobulinemia (HP:0004432)3.24328793
42Hypoplasia of the thymus (HP:0000778)3.24045547
43Prolonged partial thromboplastin time (HP:0003645)3.22120211
44Granulocytopenia (HP:0001913)3.22035342
45Deep venous thrombosis (HP:0002625)3.19230368
46Abnormality of eosinophils (HP:0001879)3.18453013
47Abnormality of monocarboxylic acid metabolism (HP:0010996)3.18332163
48Nephronophthisis (HP:0000090)3.17689030
49Abnormality of T cell physiology (HP:0011840)3.16643613
50Abnormality of dental color (HP:0011073)3.11279658
51Thyroiditis (HP:0100646)3.10771188
52Pancreatic cysts (HP:0001737)3.09012462
53Abnormality of the fingertips (HP:0001211)3.02938387
54Stomatitis (HP:0010280)3.02182719
55Autoimmune hemolytic anemia (HP:0001890)3.01038205
56Proximal tubulopathy (HP:0000114)2.99925073
57Autoimmune thrombocytopenia (HP:0001973)2.99717977
58Intrahepatic cholestasis (HP:0001406)2.97698669
59Joint hemorrhage (HP:0005261)2.97597007
60Eczematoid dermatitis (HP:0000976)2.94530037
61Meningitis (HP:0001287)2.93616701
62Lymphopenia (HP:0001888)2.92868771
63Abnormal urine output (HP:0012590)2.91601511
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.89666056
65Abnormality of the renal medulla (HP:0100957)2.89638085
66Inflammation of the large intestine (HP:0002037)2.85719340
67Increased IgM level (HP:0003496)2.83106807
68IgA deficiency (HP:0002720)2.81843189
69Gingival bleeding (HP:0000225)2.81041951
70Decreased circulating renin level (HP:0003351)2.77725827
71Hyperlipoproteinemia (HP:0010980)2.77181616
72Colitis (HP:0002583)2.76670726
73Vasculitis (HP:0002633)2.75555712
74Gastrointestinal inflammation (HP:0004386)2.74572529
75Decreased electroretinogram (ERG) amplitude (HP:0000654)2.72346414
76Abnormality of macular pigmentation (HP:0008002)2.70562391
77Encephalitis (HP:0002383)2.69414639
78Xanthomatosis (HP:0000991)2.69351247
79Absent/shortened dynein arms (HP:0200106)2.67897425
80Dynein arm defect of respiratory motile cilia (HP:0012255)2.67897425
81Myositis (HP:0100614)2.65332234
82Recurrent skin infections (HP:0001581)2.63939327
83Abnormality of the nasal mucosa (HP:0000433)2.61983265
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60505479
85Leukocytosis (HP:0001974)2.58660429
86Abnormal rod and cone electroretinograms (HP:0008323)2.58232458
87Severe visual impairment (HP:0001141)2.56320976
88Pancreatic fibrosis (HP:0100732)2.51816280
89Abnormality of pyrimidine metabolism (HP:0004353)2.51099128
90Abolished electroretinogram (ERG) (HP:0000550)2.50802108
91Chronic hepatic failure (HP:0100626)2.49436692
92Febrile seizures (HP:0002373)2.49244638
93Chronic sinusitis (HP:0011109)2.48818275
94Abnormality of renal excretion (HP:0011036)2.48812556
95Hypothermia (HP:0002045)2.47161248
96Keratoconus (HP:0000563)2.47107664
97Increased corneal curvature (HP:0100692)2.47107664
98Focal seizures (HP:0007359)2.46450888
99Focal motor seizures (HP:0011153)2.45810995
100Sclerocornea (HP:0000647)2.45645666
101Bronchitis (HP:0012387)2.45021950
102Abnormality of the renal cortex (HP:0011035)2.44774159
103Polydipsia (HP:0001959)2.42041922
104Abnormal drinking behavior (HP:0030082)2.42041922
105Abnormality of sulfur amino acid metabolism (HP:0004339)2.40374205
106Myocardial infarction (HP:0001658)2.40262285
107Abnormality of methionine metabolism (HP:0010901)2.39753457
108Mitral stenosis (HP:0001718)2.39442943
109Epistaxis (HP:0000421)2.38769137
110Chronic bronchitis (HP:0004469)2.37897823
111Verrucae (HP:0200043)2.35045492
112Papilloma (HP:0012740)2.35045492
113Spontaneous hematomas (HP:0007420)2.34792676
114Gastrointestinal infarctions (HP:0005244)2.34694943
115Lymphoma (HP:0002665)2.34253848
116True hermaphroditism (HP:0010459)2.32455933
117Inability to walk (HP:0002540)2.32045689
118Clumsiness (HP:0002312)2.31027281
119Recurrent gram-negative bacterial infections (HP:0005420)2.30501124
120Stomach cancer (HP:0012126)2.28455071
121Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.28154111
122Dialeptic seizures (HP:0011146)2.26337118
123Bony spicule pigmentary retinopathy (HP:0007737)2.25936627
124Recurrent otitis media (HP:0000403)2.24467950
125Cystic liver disease (HP:0006706)2.24437909
126Central scotoma (HP:0000603)2.23615354
127Mediastinal lymphadenopathy (HP:0100721)2.23109279
128Macular degeneration (HP:0000608)2.21690092
129Protruding tongue (HP:0010808)2.20904357
130Hypochromic anemia (HP:0001931)2.19924764
131Type II lissencephaly (HP:0007260)2.19844857
132Abnormal ciliary motility (HP:0012262)2.18954433
133Cerebellar dysplasia (HP:0007033)2.18838155
134Abnormality of the common coagulation pathway (HP:0010990)2.18617760
135Pulmonary embolism (HP:0002204)2.17662804
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16681785
137Cheilitis (HP:0100825)2.15207797
138Congenital sensorineural hearing impairment (HP:0008527)2.14547308
139Hypoplasia of the fovea (HP:0007750)2.13198794
140Aplasia/Hypoplasia of the fovea (HP:0008060)2.13198794
141Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13014409
142Gastrointestinal stroma tumor (HP:0100723)2.12847450
143Recurrent abscess formation (HP:0002722)2.12810993
144Abnormal respiratory motile cilium physiology (HP:0012261)2.12714636
145Recurrent bacterial skin infections (HP:0005406)2.12696390
146Abnormality of renin-angiotensin system (HP:0000847)2.12633242
147Absent speech (HP:0001344)2.09098244
148Increased neuronal autofluorescent lipopigment (HP:0002074)2.08507732
149Widely spaced teeth (HP:0000687)2.07463435
150Abnormality of calcium-phosphate metabolism (HP:0100530)2.06475551
151Conjugated hyperbilirubinemia (HP:0002908)2.06403468
152Abnormal protein glycosylation (HP:0012346)2.04925515
153Abnormal glycosylation (HP:0012345)2.04925515
154Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04925515
155Abnormal protein N-linked glycosylation (HP:0012347)2.04925515
156Hepatitis (HP:0012115)2.04711784
157Hypolipoproteinemia (HP:0010981)2.04054821
158Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03494763
159Abnormal platelet volume (HP:0011876)2.03285423
160Hemiparesis (HP:0001269)2.02931057
161Periodontitis (HP:0000704)2.01592632
162Ectopic kidney (HP:0000086)2.01482128
163Visual hallucinations (HP:0002367)2.01093248
164Hypochromic microcytic anemia (HP:0004840)2.00503906
165Hyperglycinemia (HP:0002154)2.00237328
166Medial flaring of the eyebrow (HP:0010747)1.99239090
167Hemoptysis (HP:0002105)1.99210612
168Prolonged bleeding time (HP:0003010)1.99190060
169Complement deficiency (HP:0004431)1.97761816
170Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96923582
171Renal cortical cysts (HP:0000803)1.96918229
172Hypoplasia of the pons (HP:0012110)1.95335295
173Constricted visual fields (HP:0001133)1.94029040
174Abnormality of the prostate (HP:0008775)1.93977251
175Hyperammonemia (HP:0001987)1.93850328
176Hypoplasia of the iris (HP:0007676)1.93478099
177Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93030837
178Volvulus (HP:0002580)1.92730247
179Pulmonary infiltrates (HP:0002113)1.92244503
180Thrombocytosis (HP:0001894)1.91642437
181Ketosis (HP:0001946)1.90639258
182Narrow nasal bridge (HP:0000446)1.88967517
183Hyperaldosteronism (HP:0000859)1.86876450
184Hypoplastic ischia (HP:0003175)1.85783957
185Intestinal atresia (HP:0011100)1.85198644
186Epileptic encephalopathy (HP:0200134)1.84285398
187Poikiloderma (HP:0001029)1.83736830
188Abnormality of the pubic bones (HP:0003172)1.83489082
189Abnormality of the pons (HP:0007361)1.83419072
190Absence seizures (HP:0002121)1.81940406
191Impaired smooth pursuit (HP:0007772)1.80133176
192Overgrowth (HP:0001548)1.77435604
193Broad-based gait (HP:0002136)1.73325682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.99772072
2INSRR5.46112768
3MAP4K15.43609806
4TXK4.67942930
5NTRK24.40598317
6FGFR43.36590870
7JAK32.99294618
8TYK22.85431965
9MAP3K142.78096263
10ZAP702.71723116
11GRK62.58782335
12IKBKE2.52740201
13ITK2.41550892
14MAP4K22.32194812
15STK102.25987314
16MAP3K102.21786899
17NLK2.19219309
18GRK12.00194411
19BMPR1B1.88360909
20JAK11.81409689
21TBK11.80708463
22MAP3K131.77633872
23CSK1.76635125
24STK31.75513554
25FGFR31.74681757
26TEC1.70661573
27SYK1.64673277
28LCK1.58325206
29NME21.55664871
30EEF2K1.52300389
31CASK1.52285713
32NTRK31.51841449
33BLK1.51080873
34IKBKB1.50915954
35BTK1.49592950
36CDK121.44991689
37ZAK1.43905114
38SIK31.41803691
39MST41.40045788
40MARK31.36344223
41BMPR21.34526101
42IRAK41.33015064
43HCK1.28296845
44PIM11.27860718
45STK38L1.27686177
46PTK2B1.27297390
47SIK11.26668772
48ADRBK11.23416830
49WNK31.21049256
50PINK11.18678451
51PRKCE1.15449377
52LATS11.13316641
53MAP3K71.13061567
54MAPK131.12487912
55NUAK11.10933582
56STK391.10049264
57DAPK21.08432312
58RIPK41.07741196
59PRKCQ1.07365138
60KIT1.06808350
61PIK3CG1.06534324
62CHUK1.05777797
63IRAK31.05004632
64CSF1R1.04722523
65WNK41.03991237
66ERN11.03914828
67MAPK111.01996198
68TNIK1.01041012
69OXSR11.01009636
70SIK20.99929216
71CDK40.98369593
72PASK0.91757423
73FLT30.90810646
74KDR0.90610094
75LYN0.89190376
76MUSK0.88726293
77TGFBR20.84379085
78ACVR1B0.83874268
79PKN20.83730136
80TAOK30.83007842
81FGFR20.82191823
82JAK20.81052081
83PRKAA10.80363113
84TLK10.79058353
85CLK10.76512006
86RPS6KA40.75070449
87CAMKK10.74039289
88PRKCH0.72127287
89STK40.68418927
90MAPK70.67403556
91LRRK20.67143957
92PRKAA20.66455357
93BRD40.66443075
94BCKDK0.64130807
95PRKCG0.63025919
96PAK30.61571431
97AKT30.61182096
98TRIM280.60360013
99EPHA30.59361178
100EPHB10.58759206
101NEK20.58379643
102MAP3K40.58019694
103GRK70.56454695
104CAMK1D0.52167171
105MAPK40.51773484
106CAMKK20.50128165
107CDK60.49579267
108CAMK2A0.48117418
109IRAK10.47775641
110TNK20.46861883
111PDK10.46789917
112SRPK10.45431214
113PLK20.44034775
114NEK90.43913467
115ATR0.42465170
116MELK0.42346172
117TESK20.42240867
118TSSK60.41159462
119PRKACA0.39700718
120CSNK1A10.39694937
121PDGFRB0.39693369
122PRKCA0.39275540
123CAMK40.39145088
124HIPK20.39046842
125PDK20.38880598
126FER0.38187508
127CAMK1G0.37812909
128WNK10.37418568
129VRK10.37193069
130STK380.37190261
131MAPK120.36494211
132CAMK10.36109297
133PKN10.35612066
134MAP2K60.35088567
135CDC42BPA0.34929314
136SGK30.34427653
137ADRBK20.34082818
138MAPK30.33876881
139TIE10.33612911
140YES10.33402415
141INSR0.33398871
142STK240.33219537
143RPS6KB20.32597161
144MAP2K30.32531383
145ERBB20.32209058
146EIF2AK30.31113325
147CDC70.31032490
148CDK90.28580071
149MKNK20.28089444
150PRKACB0.27346604
151STK110.27148654
152BRSK20.26374003
153FES0.26320376
154PTK60.25818779
155MARK20.25705666
156EIF2AK20.25627787
157ABL10.25337932
158GRK50.25149205
159MATK0.24894325
160PRKACG0.24616541
161PRKCB0.24168373
162TRPM70.23405325
163MAPKAPK30.23179211
164RPS6KA50.22348769
165RPS6KA30.22299101
166IGF1R0.22227121
167CHEK10.19989388
168ALK0.18051917

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.88764142
2Olfactory transduction_Homo sapiens_hsa047403.25491327
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.88804611
4Taste transduction_Homo sapiens_hsa047422.83789437
5Linoleic acid metabolism_Homo sapiens_hsa005912.71441725
6Morphine addiction_Homo sapiens_hsa050322.65105549
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.63850221
8T cell receptor signaling pathway_Homo sapiens_hsa046602.59035814
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.56964599
10Nicotine addiction_Homo sapiens_hsa050332.51693217
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.40263725
12GABAergic synapse_Homo sapiens_hsa047272.32474017
13Phototransduction_Homo sapiens_hsa047442.20400223
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18419206
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18259221
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18090502
17Glutamatergic synapse_Homo sapiens_hsa047242.16464372
18Measles_Homo sapiens_hsa051622.15133113
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03867526
20Ovarian steroidogenesis_Homo sapiens_hsa049132.01212699
21Staphylococcus aureus infection_Homo sapiens_hsa051502.00218954
22Circadian entrainment_Homo sapiens_hsa047132.00005330
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90568874
24Insulin secretion_Homo sapiens_hsa049111.88897305
25Allograft rejection_Homo sapiens_hsa053301.83982842
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83259550
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.81386599
28Complement and coagulation cascades_Homo sapiens_hsa046101.78951035
29Salivary secretion_Homo sapiens_hsa049701.70141975
30Ether lipid metabolism_Homo sapiens_hsa005651.68642030
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67855384
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.67061226
33Arginine biosynthesis_Homo sapiens_hsa002201.66853945
34Cocaine addiction_Homo sapiens_hsa050301.66544952
35Graft-versus-host disease_Homo sapiens_hsa053321.66448033
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.62875694
37Serotonergic synapse_Homo sapiens_hsa047261.61290948
38Tryptophan metabolism_Homo sapiens_hsa003801.61258005
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57888646
40Caffeine metabolism_Homo sapiens_hsa002321.56224549
41Hematopoietic cell lineage_Homo sapiens_hsa046401.55308195
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54565494
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53599887
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50759378
45Antigen processing and presentation_Homo sapiens_hsa046121.48827064
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48159628
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.47214831
48One carbon pool by folate_Homo sapiens_hsa006701.43681970
49Herpes simplex infection_Homo sapiens_hsa051681.40193699
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39405461
51B cell receptor signaling pathway_Homo sapiens_hsa046621.36771845
52Gastric acid secretion_Homo sapiens_hsa049711.35909911
53Non-homologous end-joining_Homo sapiens_hsa034501.33021599
54Calcium signaling pathway_Homo sapiens_hsa040201.29780299
55Cholinergic synapse_Homo sapiens_hsa047251.29658902
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27665050
57Autoimmune thyroid disease_Homo sapiens_hsa053201.23796979
58Arachidonic acid metabolism_Homo sapiens_hsa005901.23495354
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.22706478
60ABC transporters_Homo sapiens_hsa020101.21982975
61Dorso-ventral axis formation_Homo sapiens_hsa043201.16102254
62Asthma_Homo sapiens_hsa053101.15782810
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15573836
64Fatty acid degradation_Homo sapiens_hsa000711.13396109
65Nitrogen metabolism_Homo sapiens_hsa009101.13212636
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.13086903
67Oxytocin signaling pathway_Homo sapiens_hsa049211.12693479
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12345990
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12312014
70Chemical carcinogenesis_Homo sapiens_hsa052041.12238232
71Peroxisome_Homo sapiens_hsa041461.11385865
72Leishmaniasis_Homo sapiens_hsa051401.10377871
73Selenocompound metabolism_Homo sapiens_hsa004501.09875381
74Osteoclast differentiation_Homo sapiens_hsa043801.07471667
75Lysine degradation_Homo sapiens_hsa003101.07350595
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06998219
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05578589
78Fat digestion and absorption_Homo sapiens_hsa049751.05386787
79Pancreatic secretion_Homo sapiens_hsa049721.01709600
80NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00386640
81Retinol metabolism_Homo sapiens_hsa008300.99760959
82Histidine metabolism_Homo sapiens_hsa003400.98958052
83beta-Alanine metabolism_Homo sapiens_hsa004100.96914105
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93212604
85Sulfur metabolism_Homo sapiens_hsa009200.90776056
86Base excision repair_Homo sapiens_hsa034100.90731109
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.90449283
88Amphetamine addiction_Homo sapiens_hsa050310.87996894
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87995305
90Acute myeloid leukemia_Homo sapiens_hsa052210.87230012
91Synaptic vesicle cycle_Homo sapiens_hsa047210.86880312
92Folate biosynthesis_Homo sapiens_hsa007900.86397490
93Influenza A_Homo sapiens_hsa051640.85631833
94Circadian rhythm_Homo sapiens_hsa047100.84389544
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84107275
96Thyroid hormone synthesis_Homo sapiens_hsa049180.83199294
97Collecting duct acid secretion_Homo sapiens_hsa049660.83037163
98DNA replication_Homo sapiens_hsa030300.82673122
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81516022
100PPAR signaling pathway_Homo sapiens_hsa033200.79080622
101Dopaminergic synapse_Homo sapiens_hsa047280.78842295
102Phenylalanine metabolism_Homo sapiens_hsa003600.76647181
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.76046896
104Hepatitis B_Homo sapiens_hsa051610.74963246
105Mismatch repair_Homo sapiens_hsa034300.74279112
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74128757
107Sulfur relay system_Homo sapiens_hsa041220.73978778
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73508599
109Platelet activation_Homo sapiens_hsa046110.72669786
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71567188
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71181333
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69717229
113cAMP signaling pathway_Homo sapiens_hsa040240.69375724
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66303703
115Pentose phosphate pathway_Homo sapiens_hsa000300.65303056
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64579449
117Viral myocarditis_Homo sapiens_hsa054160.64516577
118Renin secretion_Homo sapiens_hsa049240.63555661
119TNF signaling pathway_Homo sapiens_hsa046680.63337649
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63179900
121Toxoplasmosis_Homo sapiens_hsa051450.62774822
122Hepatitis C_Homo sapiens_hsa051600.62405696
123Vitamin B6 metabolism_Homo sapiens_hsa007500.60712628
124Tyrosine metabolism_Homo sapiens_hsa003500.60515110
125Sphingolipid metabolism_Homo sapiens_hsa006000.59933478
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.59510208
127Vitamin digestion and absorption_Homo sapiens_hsa049770.59275205
128Epstein-Barr virus infection_Homo sapiens_hsa051690.58704986
129Apoptosis_Homo sapiens_hsa042100.58475462
130Fatty acid metabolism_Homo sapiens_hsa012120.57355755
131Legionellosis_Homo sapiens_hsa051340.56583960
132Rheumatoid arthritis_Homo sapiens_hsa053230.56204837
133Biosynthesis of amino acids_Homo sapiens_hsa012300.55672502
134Chemokine signaling pathway_Homo sapiens_hsa040620.55046168
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53311803
136Type I diabetes mellitus_Homo sapiens_hsa049400.52825123
137Propanoate metabolism_Homo sapiens_hsa006400.52554353
138HTLV-I infection_Homo sapiens_hsa051660.51222778
139Estrogen signaling pathway_Homo sapiens_hsa049150.51167418
140Butanoate metabolism_Homo sapiens_hsa006500.51010797
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50224972
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49277118
143Viral carcinogenesis_Homo sapiens_hsa052030.47035528
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44237331
145Glycerolipid metabolism_Homo sapiens_hsa005610.44228052
146Purine metabolism_Homo sapiens_hsa002300.44214242
147Homologous recombination_Homo sapiens_hsa034400.43790930
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43389755
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.42635147
150Type II diabetes mellitus_Homo sapiens_hsa049300.42372174
151Fanconi anemia pathway_Homo sapiens_hsa034600.41581776
152Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41519898
153Spliceosome_Homo sapiens_hsa030400.40822584
154Ribosome_Homo sapiens_hsa030100.40071761
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.39700433
156Pyrimidine metabolism_Homo sapiens_hsa002400.38903317
157Bile secretion_Homo sapiens_hsa049760.38278268
158Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37489086
159Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36249348
160Starch and sucrose metabolism_Homo sapiens_hsa005000.35455478
161Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34969025
162Systemic lupus erythematosus_Homo sapiens_hsa053220.34528261
163RNA degradation_Homo sapiens_hsa030180.33254074
164Regulation of autophagy_Homo sapiens_hsa041400.30254837
165Dilated cardiomyopathy_Homo sapiens_hsa054140.28860252
166African trypanosomiasis_Homo sapiens_hsa051430.28592230
167Basal transcription factors_Homo sapiens_hsa030220.26521509
168Ras signaling pathway_Homo sapiens_hsa040140.24761214
169GnRH signaling pathway_Homo sapiens_hsa049120.24270075

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