FAM169A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)6.49656036
2rhodopsin mediated signaling pathway (GO:0016056)6.44423562
3retinal cone cell development (GO:0046549)5.89942428
4photoreceptor cell development (GO:0042461)4.81700077
5retinal rod cell development (GO:0046548)4.72540039
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.72347801
7eye photoreceptor cell development (GO:0042462)4.62204371
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.28411370
9photoreceptor cell maintenance (GO:0045494)4.15187544
10presynaptic membrane assembly (GO:0097105)4.14000184
11regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.10136915
12detection of light stimulus involved in visual perception (GO:0050908)4.09648667
13detection of light stimulus involved in sensory perception (GO:0050962)4.09648667
14synaptic vesicle maturation (GO:0016188)3.99717510
15regulation of posttranscriptional gene silencing (GO:0060147)3.95847939
16regulation of gene silencing by miRNA (GO:0060964)3.95847939
17regulation of gene silencing by RNA (GO:0060966)3.95847939
18protein localization to synapse (GO:0035418)3.88565332
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.86759532
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.82037579
21GMP metabolic process (GO:0046037)3.79709118
22synaptic vesicle exocytosis (GO:0016079)3.79445875
23presynaptic membrane organization (GO:0097090)3.74132572
24glutamate secretion (GO:0014047)3.70812723
25pre-miRNA processing (GO:0031054)3.62235690
26regulation of synaptic vesicle exocytosis (GO:2000300)3.56788219
27protein-chromophore linkage (GO:0018298)3.50341160
28mitotic sister chromatid cohesion (GO:0007064)3.41248008
29atrial cardiac muscle cell action potential (GO:0086014)3.38918091
30phototransduction (GO:0007602)3.38364632
31nuclear pore organization (GO:0006999)3.33220299
32cellular response to light stimulus (GO:0071482)3.32093002
33detection of light stimulus (GO:0009583)3.28753908
34detection of visible light (GO:0009584)3.27787389
35phototransduction, visible light (GO:0007603)3.26257857
36vocalization behavior (GO:0071625)3.26163868
37postsynaptic membrane organization (GO:0001941)3.23915078
38nuclear pore complex assembly (GO:0051292)3.19746425
39positive regulation of synapse maturation (GO:0090129)3.18807722
40negative regulation of translation, ncRNA-mediated (GO:0040033)3.14180158
41regulation of translation, ncRNA-mediated (GO:0045974)3.14180158
42negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.14180158
43visual perception (GO:0007601)3.10450915
44dorsal/ventral axis specification (GO:0009950)3.09822079
45regulation of helicase activity (GO:0051095)3.08646822
46sensory perception of light stimulus (GO:0050953)3.08114700
47regulation of synaptic vesicle transport (GO:1902803)3.06340091
48positive regulation of guanylate cyclase activity (GO:0031284)3.02871550
49regulation of clathrin-mediated endocytosis (GO:2000369)3.02449033
50histone arginine methylation (GO:0034969)3.01855666
51layer formation in cerebral cortex (GO:0021819)3.01670213
52neurotransmitter secretion (GO:0007269)3.00931097
53peptidyl-arginine omega-N-methylation (GO:0035247)3.00813652
54locomotory exploration behavior (GO:0035641)2.98165334
55neuron cell-cell adhesion (GO:0007158)2.97035494
56regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.95999265
57lysine metabolic process (GO:0006553)2.91916182
58lysine catabolic process (GO:0006554)2.91916182
59regulation of glutamate receptor signaling pathway (GO:1900449)2.91880542
60negative regulation of histone methylation (GO:0031061)2.90841059
61synaptic vesicle endocytosis (GO:0048488)2.89926589
62response to histamine (GO:0034776)2.89329140
63peptidyl-arginine N-methylation (GO:0035246)2.87587378
64peptidyl-arginine methylation (GO:0018216)2.87587378
65innervation (GO:0060384)2.87226331
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.84819274
67negative regulation of DNA recombination (GO:0045910)2.82532347
68regulation of centriole replication (GO:0046599)2.80864902
69establishment of integrated proviral latency (GO:0075713)2.79953882
70histone H4-K12 acetylation (GO:0043983)2.72750272
71neuron-neuron synaptic transmission (GO:0007270)2.70163114
72mitochondrion transport along microtubule (GO:0047497)2.69107315
73establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.69107315
74regulation of guanylate cyclase activity (GO:0031282)2.66622275
75neurotransmitter transport (GO:0006836)2.66413376
76ionotropic glutamate receptor signaling pathway (GO:0035235)2.61986789
77membrane hyperpolarization (GO:0060081)2.61681353
78positive regulation of neurotransmitter transport (GO:0051590)2.61057957
79regulation of translational termination (GO:0006449)2.58897728
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.57174554
81retina development in camera-type eye (GO:0060041)2.56841468
82cell migration in hindbrain (GO:0021535)2.56247051
83lung-associated mesenchyme development (GO:0060484)2.55133075
84positive regulation of dendritic spine morphogenesis (GO:0061003)2.54493535
85paraxial mesoderm development (GO:0048339)2.53338894
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52573492
87negative regulation of DNA-dependent DNA replication (GO:2000104)2.52350221
88DNA double-strand break processing (GO:0000729)2.52240724
89regulation of meiosis I (GO:0060631)2.50508475
90L-amino acid import (GO:0043092)2.49991383
91C4-dicarboxylate transport (GO:0015740)2.49869982
92regulation of histone H3-K9 methylation (GO:0051570)2.49531855
93cerebellar Purkinje cell differentiation (GO:0021702)2.49461882
94regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.49139240
95behavioral fear response (GO:0001662)2.48720743
96behavioral defense response (GO:0002209)2.48720743
97synaptic transmission, glutamatergic (GO:0035249)2.48450341
98chromatin remodeling at centromere (GO:0031055)2.47234883
99L-serine metabolic process (GO:0006563)2.46187324
100pore complex assembly (GO:0046931)2.45761103
101behavioral response to ethanol (GO:0048149)2.45731483
102positive regulation of membrane potential (GO:0045838)2.45111702
103regulation of neurotransmitter secretion (GO:0046928)2.44893815
104cellular potassium ion homeostasis (GO:0030007)2.44831911
105detection of external stimulus (GO:0009581)2.43655146
106startle response (GO:0001964)2.43031669
107regulation of DNA methylation (GO:0044030)2.42710812
108regulation of postsynaptic membrane potential (GO:0060078)2.42699034
109neurotransmitter-gated ion channel clustering (GO:0072578)2.42473199
110detection of abiotic stimulus (GO:0009582)2.42058937
111amino acid import (GO:0043090)2.40785245
112DNA replication-dependent nucleosome assembly (GO:0006335)2.40663751
113DNA replication-dependent nucleosome organization (GO:0034723)2.40663751
114protein localization to kinetochore (GO:0034501)2.40217392
115regulation of gene silencing (GO:0060968)2.40207702
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.39953862
117somatic diversification of immune receptors via somatic mutation (GO:0002566)2.39953862
118histone exchange (GO:0043486)2.39560534
119kidney morphogenesis (GO:0060993)2.39512589
120establishment of mitochondrion localization (GO:0051654)2.39251550
121regulation of neuronal synaptic plasticity (GO:0048168)2.38203658
122striatum development (GO:0021756)2.37115440
123dendritic spine morphogenesis (GO:0060997)2.36953827
124exploration behavior (GO:0035640)2.35757086
125glutamate receptor signaling pathway (GO:0007215)2.34735858
126long-term memory (GO:0007616)2.33941535
127regulation of sister chromatid cohesion (GO:0007063)2.33821489
128regulation of synapse maturation (GO:0090128)2.33056144
129histone H4-K8 acetylation (GO:0043982)2.32688312
130histone H4-K5 acetylation (GO:0043981)2.32688312
131regulation of telomere maintenance via telomerase (GO:0032210)2.32423704
132IMP biosynthetic process (GO:0006188)2.32049320
133fear response (GO:0042596)2.31741770
134regulation of long-term neuronal synaptic plasticity (GO:0048169)2.30447316
135regulation of dendritic spine morphogenesis (GO:0061001)2.30088410
136CENP-A containing nucleosome assembly (GO:0034080)2.29875021
137spindle checkpoint (GO:0031577)2.29590922
138protein complex localization (GO:0031503)2.29008705
139regulation of centrosome cycle (GO:0046605)2.28036088
140intra-S DNA damage checkpoint (GO:0031573)2.27144060
141organ growth (GO:0035265)2.26478010
142negative regulation of chromosome segregation (GO:0051985)2.26456743
143regulation of centrosome duplication (GO:0010824)2.26341931
144aspartate family amino acid catabolic process (GO:0009068)2.26094241
145ribosome assembly (GO:0042255)2.25732097
146negative regulation of mitotic sister chromatid segregation (GO:0033048)2.25257427
147negative regulation of mitotic sister chromatid separation (GO:2000816)2.25257427
148negative regulation of sister chromatid segregation (GO:0033046)2.25257427
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.25257427
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.25257427
151mitotic spindle checkpoint (GO:0071174)2.22615433
152peristalsis (GO:0030432)2.22282323
153regulation of mitotic sister chromatid separation (GO:0010965)2.21459104
154regulation of mitotic sister chromatid segregation (GO:0033047)2.21459104
155regulation of sister chromatid segregation (GO:0033045)2.21459104
156gastrulation with mouth forming second (GO:0001702)2.21444761
157regulation of nuclear cell cycle DNA replication (GO:0033262)2.20788470
158mitotic metaphase plate congression (GO:0007080)2.19457181
159regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.19124059
160regulation of mitotic metaphase/anaphase transition (GO:0030071)2.19124059
161regulation of chromosome segregation (GO:0051983)2.18998234
162neuronal action potential propagation (GO:0019227)2.18780688
163embryonic retina morphogenesis in camera-type eye (GO:0060059)2.17850318
164single strand break repair (GO:0000012)2.17764525
165hyperosmotic salinity response (GO:0042538)2.16715274
166heterochromatin organization (GO:0070828)2.16510067
167positive regulation of chromosome segregation (GO:0051984)2.14639630
168regulation of non-canonical Wnt signaling pathway (GO:2000050)2.14593510
169DNA replication checkpoint (GO:0000076)2.14575047
170cerebellar granule cell differentiation (GO:0021707)2.14483571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.30940531
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.41528143
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.05534357
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.02426261
5EZH2_22144423_ChIP-Seq_EOC_Human2.94702200
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.49370782
7GBX2_23144817_ChIP-Seq_PC3_Human2.47155823
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.33404843
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.33404843
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.33404843
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.27779960
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.18225724
13SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.17404413
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.14839936
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.10358482
16IGF1R_20145208_ChIP-Seq_DFB_Human2.09801031
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.06284068
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03239748
19REST_21632747_ChIP-Seq_MESCs_Mouse2.00698292
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97127525
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96739566
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91186968
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88045352
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.86802291
25ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.86289046
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.84749298
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79893384
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79299486
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78973388
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.77860780
31CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.75418010
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72434994
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.71836834
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.71488347
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64886505
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62215878
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60905426
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58594598
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57490782
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56497954
41TCF3_18692474_ChIP-Seq_MESCs_Mouse1.55169417
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52451841
43* FUS_26573619_Chip-Seq_HEK293_Human1.51529883
44* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50755414
45* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50011442
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49265120
47SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.47679430
48NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.46594484
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43264132
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42525990
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42130166
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41678311
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41457223
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39427535
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38926361
56AR_21572438_ChIP-Seq_LNCaP_Human1.34619250
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34530347
58AR_21909140_ChIP-Seq_LNCAP_Human1.34505477
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34163006
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34074468
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34074468
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.33763402
63POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.31427222
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29990736
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28962721
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28777428
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27630167
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27582228
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27049656
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.26564866
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25485656
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25344289
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25044173
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24149333
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.24010754
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.22947757
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20751124
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20600624
79NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20324874
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20185372
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19678481
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19622598
83POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17923233
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17066239
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16654528
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16509591
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16496716
88TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12098623
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11757108
90TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11527709
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.10410791
92TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10271540
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09412072
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08951548
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08711083
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08290374
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06939917
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06890989
99IRF1_19129219_ChIP-ChIP_H3396_Human1.05858951
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04947480
101SMAD4_21799915_ChIP-Seq_A2780_Human1.04748305
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04642182
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04602329
104NANOG_21062744_ChIP-ChIP_HESCs_Human1.04585381
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03554796
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02022896
107KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01457075
108CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00899952
109* RNF2_27304074_Chip-Seq_NSC_Mouse1.00631152
110* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00556215
111NANOG_16518401_ChIP-PET_MESCs_Mouse0.99629348
112SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99197936
113* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98741050
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98621029
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.98412546
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97897978
117STAT3_23295773_ChIP-Seq_U87_Human0.96415211
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.96400440
119NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96382282
120ZNF274_21170338_ChIP-Seq_K562_Hela0.96299491
121EWS_26573619_Chip-Seq_HEK293_Human0.95615524
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95389743
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94798768
124YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94032653
125NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92880822
126SOX9_26525672_Chip-Seq_HEART_Mouse0.92865248
127DROSHA_22980978_ChIP-Seq_HELA_Human0.92500858
128AR_19668381_ChIP-Seq_PC3_Human0.92310984
129TAF15_26573619_Chip-Seq_HEK293_Human0.92265403
130* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91820821
131* RUNX2_22187159_ChIP-Seq_PCA_Human0.90913086
132CBP_20019798_ChIP-Seq_JUKART_Human0.90512279
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90512279
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90509392
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89693337
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89672695
137* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87878488
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87728945
139* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87639564
140AR_25329375_ChIP-Seq_VCAP_Human0.87548940
141SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.85433504
142POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85412889
143E2F1_21310950_ChIP-Seq_MCF-7_Human0.84950538
144P300_19829295_ChIP-Seq_ESCs_Human0.84900538
145* TCF4_23295773_ChIP-Seq_U87_Human0.84081750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.45697452
2MP0006072_abnormal_retinal_apoptosis3.70685433
3MP0004859_abnormal_synaptic_plasticity3.37470854
4MP0005253_abnormal_eye_physiology3.35532985
5MP0003011_delayed_dark_adaptation3.25478880
6MP0003880_abnormal_central_pattern2.91416915
7MP0004270_analgesia2.56465519
8MP0002653_abnormal_ependyma_morphology2.50145763
9MP0003635_abnormal_synaptic_transmissio2.41812730
10MP0005423_abnormal_somatic_nervous2.32256807
11MP0003123_paternal_imprinting2.17382251
12MP0008877_abnormal_DNA_methylation2.14421550
13MP0003941_abnormal_skin_development2.05260196
14MP0009046_muscle_twitch2.04223606
15MP0002063_abnormal_learning/memory/cond2.00858582
16MP0009745_abnormal_behavioral_response1.89366029
17MP0001968_abnormal_touch/_nociception1.86126563
18MP0003787_abnormal_imprinting1.86057493
19MP0005195_abnormal_posterior_eye1.82180861
20MP0002734_abnormal_mechanical_nocicepti1.81798538
21MP0002064_seizures1.81697647
22MP0001486_abnormal_startle_reflex1.75306098
23MP0001293_anophthalmia1.74585650
24MP0003890_abnormal_embryonic-extraembry1.69659350
25MP0003121_genomic_imprinting1.69549971
26MP0000566_synostosis1.69491871
27MP0005391_vision/eye_phenotype1.68839154
28MP0002572_abnormal_emotion/affect_behav1.68453464
29MP0002638_abnormal_pupillary_reflex1.66976007
30MP0003718_maternal_effect1.65096411
31MP0002272_abnormal_nervous_system1.63374683
32MP0002229_neurodegeneration1.62535292
33MP0006292_abnormal_olfactory_placode1.59632860
34MP0001984_abnormal_olfaction1.59568883
35MP0004233_abnormal_muscle_weight1.56798690
36MP0003283_abnormal_digestive_organ1.50022137
37MP0002882_abnormal_neuron_morphology1.49424626
38MP0004133_heterotaxia1.47930135
39MP0010094_abnormal_chromosome_stability1.47582287
40MP0002090_abnormal_vision1.46552631
41MP0003111_abnormal_nucleus_morphology1.45213343
42MP0003937_abnormal_limbs/digits/tail_de1.44322665
43MP0002752_abnormal_somatic_nervous1.43310522
44MP0002254_reproductive_system_inflammat1.42547569
45MP0009672_abnormal_birth_weight1.41703174
46MP0008057_abnormal_DNA_replication1.40820053
47MP0003122_maternal_imprinting1.39776116
48MP0000778_abnormal_nervous_system1.34560342
49MP0004957_abnormal_blastocyst_morpholog1.34339015
50MP0001177_atelectasis1.34187832
51MP0005499_abnormal_olfactory_system1.31462181
52MP0005394_taste/olfaction_phenotype1.31462181
53MP0002184_abnormal_innervation1.31430317
54MP0003950_abnormal_plasma_membrane1.29786633
55MP0008058_abnormal_DNA_repair1.29307356
56MP0002822_catalepsy1.27171626
57MP0003119_abnormal_digestive_system1.27134056
58MP0002067_abnormal_sensory_capabilities1.26649866
59MP0001324_abnormal_eye_pigmentation1.25475537
60MP0005386_behavior/neurological_phenoty1.24944327
61MP0004924_abnormal_behavior1.24944327
62MP0002736_abnormal_nociception_after1.24062912
63MP0002735_abnormal_chemical_nociception1.23257753
64MP0004147_increased_porphyrin_level1.20450594
65MP0004811_abnormal_neuron_physiology1.19810641
66MP0001529_abnormal_vocalization1.17793909
67MP0001299_abnormal_eye_distance/1.17405963
68MP0001440_abnormal_grooming_behavior1.17248721
69MP0004885_abnormal_endolymph1.15851283
70MP0002697_abnormal_eye_size1.14962485
71MP0000579_abnormal_nail_morphology1.14287016
72MP0000955_abnormal_spinal_cord1.11489998
73MP0003693_abnormal_embryo_hatching1.11273279
74MP0002152_abnormal_brain_morphology1.11114155
75MP0003136_yellow_coat_color1.09283072
76MP0003861_abnormal_nervous_system1.08341609
77MP0000537_abnormal_urethra_morphology1.06659665
78MP0003077_abnormal_cell_cycle1.06389324
79MP0003567_abnormal_fetal_cardiomyocyte1.06349813
80MP0009780_abnormal_chondrocyte_physiolo1.04666658
81MP0005646_abnormal_pituitary_gland1.04338421
82MP0002557_abnormal_social/conspecific_i1.03970599
83MP0001730_embryonic_growth_arrest1.02917011
84MP0002733_abnormal_thermal_nociception1.02844819
85MP0009703_decreased_birth_body1.02249461
86MP0002233_abnormal_nose_morphology1.01535219
87MP0002084_abnormal_developmental_patter1.00642996
88MP0006276_abnormal_autonomic_nervous0.99854322
89MP0001286_abnormal_eye_development0.99275698
90MP0001502_abnormal_circadian_rhythm0.98255951
91MP0001970_abnormal_pain_threshold0.97275504
92MP0003195_calcinosis0.96761910
93MP0001188_hyperpigmentation0.95950397
94MP0005645_abnormal_hypothalamus_physiol0.93615947
95MP0002938_white_spotting0.91363029
96MP0000350_abnormal_cell_proliferation0.90823933
97MP0002102_abnormal_ear_morphology0.90565671
98MP0004142_abnormal_muscle_tone0.90501348
99MP0009697_abnormal_copulation0.90392760
100MP0002066_abnormal_motor_capabilities/c0.90286942
101MP0000631_abnormal_neuroendocrine_gland0.89912824
102MP0000383_abnormal_hair_follicle0.89693876
103MP0003698_abnormal_male_reproductive0.88687178
104MP0008789_abnormal_olfactory_epithelium0.88087097
105MP0001501_abnormal_sleep_pattern0.88032995
106MP0002085_abnormal_embryonic_tissue0.85958167
107MP0005367_renal/urinary_system_phenotyp0.85789241
108MP0000516_abnormal_urinary_system0.85789241
109MP0004742_abnormal_vestibular_system0.84432160
110MP0010678_abnormal_skin_adnexa0.83806429
111MP0010307_abnormal_tumor_latency0.81658390
112MP0000569_abnormal_digit_pigmentation0.81595995
113MP0001346_abnormal_lacrimal_gland0.81050152
114MP0001697_abnormal_embryo_size0.80272123
115MP0001963_abnormal_hearing_physiology0.79585605
116MP0001986_abnormal_taste_sensitivity0.79263907
117MP0004858_abnormal_nervous_system0.77035597
118MP0002751_abnormal_autonomic_nervous0.76870758
119MP0002909_abnormal_adrenal_gland0.76527009
120MP0003632_abnormal_nervous_system0.76045673
121MP0010234_abnormal_vibrissa_follicle0.75182245
122MP0008932_abnormal_embryonic_tissue0.74902632
123MP0002210_abnormal_sex_determination0.74375769
124MP0002127_abnormal_cardiovascular_syste0.73910184
125MP0004197_abnormal_fetal_growth/weight/0.73661940
126MP0001672_abnormal_embryogenesis/_devel0.73509208
127MP0005380_embryogenesis_phenotype0.73509208
128MP0005076_abnormal_cell_differentiation0.71641056
129MP0008569_lethality_at_weaning0.71297992
130MP0001929_abnormal_gametogenesis0.70862668
131MP0001485_abnormal_pinna_reflex0.70828030

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.59914666
2Bony spicule pigmentary retinopathy (HP:0007737)6.32264872
3Central scotoma (HP:0000603)5.05142039
4Abnormal rod and cone electroretinograms (HP:0008323)5.04771708
5Absent rod-and cone-mediated responses on ERG (HP:0007688)4.93293754
6Dyschromatopsia (HP:0007641)4.76537751
7Abnormality of macular pigmentation (HP:0008002)4.47416010
8Scotoma (HP:0000575)4.46892023
9Pendular nystagmus (HP:0012043)4.22365435
10Attenuation of retinal blood vessels (HP:0007843)4.09194813
11Chorioretinal atrophy (HP:0000533)4.06335223
12Decreased central vision (HP:0007663)3.60488454
13Abnormality of the labia minora (HP:0012880)3.59559128
14Pigmentary retinal degeneration (HP:0001146)3.44087112
15Aplasia/Hypoplasia of the sternum (HP:0006714)3.40907115
16Type II diabetes mellitus (HP:0005978)3.36938264
17Hepatoblastoma (HP:0002884)3.32350732
18Severe visual impairment (HP:0001141)3.28955289
19Focal motor seizures (HP:0011153)3.23853838
20Ependymoma (HP:0002888)3.13592573
21Photophobia (HP:0000613)3.03064537
22Nephroblastoma (Wilms tumor) (HP:0002667)2.96690478
23Epileptic encephalopathy (HP:0200134)2.95183626
24Choroideremia (HP:0001139)2.90991423
25Febrile seizures (HP:0002373)2.86477116
26Abnormality of the lower motor neuron (HP:0002366)2.82579166
27Abolished electroretinogram (ERG) (HP:0000550)2.78399576
28Abnormality of the astrocytes (HP:0100707)2.77790135
29Astrocytoma (HP:0009592)2.77790135
30Embryonal renal neoplasm (HP:0011794)2.75950489
31Posterior subcapsular cataract (HP:0007787)2.69653527
32Visual hallucinations (HP:0002367)2.66437763
33Focal seizures (HP:0007359)2.58826677
34Myokymia (HP:0002411)2.56921642
35Pancreatic islet-cell hyperplasia (HP:0004510)2.52126970
36Chromsome breakage (HP:0040012)2.51577454
37Gait imbalance (HP:0002141)2.50043941
38Progressive cerebellar ataxia (HP:0002073)2.43694904
39Retinitis pigmentosa (HP:0000510)2.41621148
40Vitreoretinal degeneration (HP:0000655)2.40999732
41Constricted visual fields (HP:0001133)2.37412892
42Macular degeneration (HP:0000608)2.37083653
43Cone-rod dystrophy (HP:0000548)2.36758322
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34942368
45Atonic seizures (HP:0010819)2.32675881
46Congenital primary aphakia (HP:0007707)2.31896535
47Volvulus (HP:0002580)2.30230450
48Medulloblastoma (HP:0002885)2.28971216
49Absence seizures (HP:0002121)2.28338891
50Supernumerary spleens (HP:0009799)2.21741948
51Dysdiadochokinesis (HP:0002075)2.20397471
52Increased corneal curvature (HP:0100692)2.20279606
53Keratoconus (HP:0000563)2.20279606
54Scrotal hypoplasia (HP:0000046)2.19410314
55Glioma (HP:0009733)2.19290256
56Hyperglycinemia (HP:0002154)2.16238157
57Diastasis recti (HP:0001540)2.16210478
58Urinary bladder sphincter dysfunction (HP:0002839)2.13894855
59Neoplasm of the oral cavity (HP:0100649)2.10253583
60Impaired vibration sensation in the lower limbs (HP:0002166)2.03483307
61Septo-optic dysplasia (HP:0100842)2.02802853
62Horizontal nystagmus (HP:0000666)2.02262946
63Embryonal neoplasm (HP:0002898)2.01984128
64Broad alveolar ridges (HP:0000187)2.00013760
65Meckel diverticulum (HP:0002245)1.99768864
66Dialeptic seizures (HP:0011146)1.99468329
67Abnormal lung lobation (HP:0002101)1.98250370
68Abnormality of the clitoris (HP:0000056)1.96588269
69Nephrogenic diabetes insipidus (HP:0009806)1.96151830
70Increased nuchal translucency (HP:0010880)1.94298422
71Cutaneous finger syndactyly (HP:0010554)1.94079824
72Abnormality of the ileum (HP:0001549)1.93553140
73Bifid tongue (HP:0010297)1.92661064
74Hypobetalipoproteinemia (HP:0003563)1.92174001
75Impaired smooth pursuit (HP:0007772)1.92002697
76Clitoromegaly (HP:0000057)1.91798529
77Absent eyebrow (HP:0002223)1.91778428
78Generalized tonic-clonic seizures (HP:0002069)1.91342708
79Medial flaring of the eyebrow (HP:0010747)1.91216363
80Specific learning disability (HP:0001328)1.90690527
81Poor coordination (HP:0002370)1.89140087
82Abnormality of chromosome stability (HP:0003220)1.89132631
83Gaze-evoked nystagmus (HP:0000640)1.88462650
84Choanal stenosis (HP:0000452)1.87966999
85Oligodactyly (hands) (HP:0001180)1.87292582
86Prolonged partial thromboplastin time (HP:0003645)1.86854535
87Hyperventilation (HP:0002883)1.86666196
88Spastic diplegia (HP:0001264)1.84052037
89Neoplasm of the adrenal cortex (HP:0100641)1.83884070
90Abnormality of ocular smooth pursuit (HP:0000617)1.83696903
91Gastrointestinal carcinoma (HP:0002672)1.83326087
92Malignant gastrointestinal tract tumors (HP:0006749)1.83326087
93Chronic hepatic failure (HP:0100626)1.83016532
94Broad-based gait (HP:0002136)1.82675386
95Gastroesophageal reflux (HP:0002020)1.82653991
96Protruding tongue (HP:0010808)1.81926244
97Agnosia (HP:0010524)1.81394353
98Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80151951
99Hypoglycemic seizures (HP:0002173)1.79875773
100Optic nerve hypoplasia (HP:0000609)1.79081871
101Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78634066
102Lissencephaly (HP:0001339)1.78239542
103Abnormality of abdominal situs (HP:0011620)1.77852669
104Abdominal situs inversus (HP:0003363)1.77852669
105Colon cancer (HP:0003003)1.77042931
106Labial hypoplasia (HP:0000066)1.76359373
107Hypoplastic female external genitalia (HP:0012815)1.75853526
108Absent speech (HP:0001344)1.75474368
109Truncal ataxia (HP:0002078)1.74944090
110Cutaneous syndactyly (HP:0012725)1.74197526
111Anophthalmia (HP:0000528)1.73455310
112Cortical dysplasia (HP:0002539)1.73243879
113Abnormality of the corticospinal tract (HP:0002492)1.71872227
114Breast aplasia (HP:0100783)1.71853124
115Hyperinsulinemic hypoglycemia (HP:0000825)1.70721743
116Abnormal hair whorl (HP:0010721)1.70716155
117Amyotrophic lateral sclerosis (HP:0007354)1.70011644
118Drooling (HP:0002307)1.69677508
119Excessive salivation (HP:0003781)1.69677508
120Abnormality of the septum pellucidum (HP:0007375)1.68861093
121Rhabdomyosarcoma (HP:0002859)1.68524390
122Genital tract atresia (HP:0001827)1.68489452
123Vaginal atresia (HP:0000148)1.67870008
124Broad foot (HP:0001769)1.67794778
125Amblyopia (HP:0000646)1.66681257
126Absent radius (HP:0003974)1.64002908
127Impaired social interactions (HP:0000735)1.63573958
128Abnormal social behavior (HP:0012433)1.63573958
129Genetic anticipation (HP:0003743)1.62824690
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62244694
131Poor eye contact (HP:0000817)1.61414399
132Birth length less than 3rd percentile (HP:0003561)1.61342857
133Midline defect of the nose (HP:0004122)1.61104554
134Biliary tract neoplasm (HP:0100574)1.60677159
135Action tremor (HP:0002345)1.60615618
136Wide nasal bridge (HP:0000431)1.60327861
137Thyroid carcinoma (HP:0002890)1.59800548
138Alacrima (HP:0000522)1.59628889
139Esophageal atresia (HP:0002032)1.59310072
140Urinary urgency (HP:0000012)1.58977124
141Aplasia involving forearm bones (HP:0009822)1.57797876
142Absent forearm bone (HP:0003953)1.57797876
143Intestinal atresia (HP:0011100)1.57783082
144Shoulder girdle muscle weakness (HP:0003547)1.54507675
145Papillary thyroid carcinoma (HP:0002895)1.54028490
146Postural instability (HP:0002172)1.53649730
147Resting tremor (HP:0002322)1.52517177
148Epileptiform EEG discharges (HP:0011182)1.50520996
149Bradykinesia (HP:0002067)1.49122034
150Neoplasm of striated muscle (HP:0009728)1.47986459
151Rectal fistula (HP:0100590)1.46874490
152Rectovaginal fistula (HP:0000143)1.46874490
153EEG with generalized epileptiform discharges (HP:0011198)1.46856515
154Subcapsular cataract (HP:0000523)1.46178494
155Dysmetric saccades (HP:0000641)1.43890818
156Spastic gait (HP:0002064)1.43530226
157Aqueductal stenosis (HP:0002410)1.43285234
158Optic disc pallor (HP:0000543)1.43086426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.29495405
2MAP3K93.02399564
3MAP3K43.01384422
4TNIK2.95683368
5NEK12.88519833
6NTRK32.76818950
7MARK12.63807559
8ZAK2.41927468
9FGFR22.21824378
10CDK122.20427348
11AKT32.14956653
12CDC72.12839037
13GRK12.10263597
14MINK11.94596349
15EPHA41.93375412
16BMPR1B1.89114928
17MAP2K71.85725894
18TSSK61.74729880
19TAF11.67209404
20PLK31.66786744
21CASK1.65368843
22PLK21.61514133
23PAK61.59376007
24KSR11.57915064
25WEE11.54845732
26TTK1.53720300
27SRPK11.48978779
28TRIM281.42631823
29SCYL21.41254157
30PRKD31.39307316
31PLK41.37633246
32LATS21.36698646
33MAP2K41.34520887
34BRD41.31241110
35WNK31.30787029
36PBK1.30398399
37LATS11.29068826
38NTRK21.27111648
39CAMK1G1.27086527
40STK381.26107029
41ALK1.24712935
42WNK41.19236410
43PDK31.18112841
44PDK41.18112841
45EPHA21.14875224
46BRSK21.14730549
47CAMK1D1.14555549
48KSR21.12020815
49CHEK21.10675251
50EIF2AK31.08229852
51NEK21.03103524
52DAPK11.02858909
53PLK11.01477755
54DAPK20.98188813
55CSNK1G10.97929377
56ERBB40.97080292
57PINK10.93967911
58WNK10.91741172
59MKNK20.91306367
60BRAF0.89396684
61STK390.88586202
62CHEK10.88570920
63PRKCG0.84904473
64STK38L0.84881617
65BCR0.84778996
66CSNK1D0.84371906
67BUB10.82965463
68CDK50.82089255
69DYRK1A0.81189166
70GRK50.78595879
71CAMKK10.77693317
72CDK180.76453262
73MAP3K120.76055257
74CSNK1E0.75965206
75MAPK130.75654884
76AURKA0.75466301
77PRPF4B0.74818432
78CDK140.74567410
79CDK150.73382835
80ATR0.73218578
81PDK20.72564498
82ATM0.71799926
83CCNB10.71520222
84CSNK1A1L0.71332140
85CDK20.70815844
86SGK20.69699182
87NUAK10.68876330
88FRK0.68224996
89DYRK20.67567520
90BRSK10.66585346
91MKNK10.65676424
92CDK30.65266144
93NTRK10.64985563
94CDK10.63441758
95CDK11A0.63045757
96MST40.62941899
97MAPK100.59324449
98PRKCI0.58427853
99STK30.57486755
100CDK190.57343223
101PRKDC0.56973017
102PASK0.56672953
103SGK4940.56157372
104SGK2230.56157372
105STK110.56098212
106FGR0.55135847
107UHMK10.55119049
108GSK3B0.54916043
109NEK60.54775488
110FGFR30.51593594
111RPS6KA30.50732448
112CSNK1G20.50568744
113EIF2AK20.50418981
114CSNK1G30.50185656
115SGK10.49515662
116SIK20.48991057
117ACVR1B0.48863574
118RPS6KB10.47293412
119MAPK140.46555477
120YES10.46541163
121TYRO30.46056175
122NLK0.45763959
123ERBB30.44932647
124TGFBR10.44691095
125ADRBK10.44619742
126TLK10.44116401
127PAK30.44015866
128VRK10.44001252
129CAMK2A0.43385079
130CAMK40.43359590
131FER0.43010007
132FGFR10.40843028
133CDC42BPA0.40838032
134SGK30.39344998

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.91343481
2Synaptic vesicle cycle_Homo sapiens_hsa047213.18833232
3Nicotine addiction_Homo sapiens_hsa050332.88445183
4Olfactory transduction_Homo sapiens_hsa047402.29360780
5GABAergic synapse_Homo sapiens_hsa047272.28934438
6Vitamin B6 metabolism_Homo sapiens_hsa007502.24645062
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07496785
8Long-term potentiation_Homo sapiens_hsa047201.95015829
9Morphine addiction_Homo sapiens_hsa050321.87454908
10Circadian entrainment_Homo sapiens_hsa047131.87068721
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82827716
12Dopaminergic synapse_Homo sapiens_hsa047281.78617061
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77082943
14Glutamatergic synapse_Homo sapiens_hsa047241.74270462
15Steroid biosynthesis_Homo sapiens_hsa001001.69456578
16Propanoate metabolism_Homo sapiens_hsa006401.69064081
17Oocyte meiosis_Homo sapiens_hsa041141.66529319
18Amphetamine addiction_Homo sapiens_hsa050311.66312268
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60276890
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56827013
21Mismatch repair_Homo sapiens_hsa034301.54575373
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.53316245
23RNA transport_Homo sapiens_hsa030131.51102083
24mRNA surveillance pathway_Homo sapiens_hsa030151.47760146
25Insulin secretion_Homo sapiens_hsa049111.45909749
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43769174
27Selenocompound metabolism_Homo sapiens_hsa004501.42220224
28Cholinergic synapse_Homo sapiens_hsa047251.38736047
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37682656
30Serotonergic synapse_Homo sapiens_hsa047261.28379972
31Alcoholism_Homo sapiens_hsa050341.24323197
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23403376
33Arginine biosynthesis_Homo sapiens_hsa002201.18785554
34Taste transduction_Homo sapiens_hsa047421.17525880
35Salivary secretion_Homo sapiens_hsa049701.16968915
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16556488
37Fatty acid biosynthesis_Homo sapiens_hsa000611.15792455
38Collecting duct acid secretion_Homo sapiens_hsa049661.13514684
39Lysine degradation_Homo sapiens_hsa003101.12631678
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11751357
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11584719
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10584268
43Spliceosome_Homo sapiens_hsa030401.10290855
44Oxytocin signaling pathway_Homo sapiens_hsa049211.09870996
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08114401
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07491973
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00321031
48Long-term depression_Homo sapiens_hsa047300.99994732
49Renin secretion_Homo sapiens_hsa049240.98067832
50Arginine and proline metabolism_Homo sapiens_hsa003300.96417779
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96412779
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94669117
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94516013
54Adherens junction_Homo sapiens_hsa045200.89753066
55RNA polymerase_Homo sapiens_hsa030200.89400142
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89118537
57Gastric acid secretion_Homo sapiens_hsa049710.88674791
58mTOR signaling pathway_Homo sapiens_hsa041500.88578749
59RNA degradation_Homo sapiens_hsa030180.88574241
60Cell cycle_Homo sapiens_hsa041100.88108005
61Cardiac muscle contraction_Homo sapiens_hsa042600.87994077
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87066191
63Calcium signaling pathway_Homo sapiens_hsa040200.86943018
64Fanconi anemia pathway_Homo sapiens_hsa034600.85956329
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85844019
66Cocaine addiction_Homo sapiens_hsa050300.84114084
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83493320
68Gap junction_Homo sapiens_hsa045400.82210997
69Vibrio cholerae infection_Homo sapiens_hsa051100.81185951
70Butanoate metabolism_Homo sapiens_hsa006500.80930805
71Nucleotide excision repair_Homo sapiens_hsa034200.79810950
72Basal transcription factors_Homo sapiens_hsa030220.78910929
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.77523436
74DNA replication_Homo sapiens_hsa030300.75495767
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75180111
76GnRH signaling pathway_Homo sapiens_hsa049120.74365259
77Type II diabetes mellitus_Homo sapiens_hsa049300.74320131
78Melanogenesis_Homo sapiens_hsa049160.74194127
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72761098
80Fatty acid metabolism_Homo sapiens_hsa012120.71816302
81Hippo signaling pathway_Homo sapiens_hsa043900.71748586
82ErbB signaling pathway_Homo sapiens_hsa040120.70353167
83Estrogen signaling pathway_Homo sapiens_hsa049150.69738838
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69591329
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.68620135
86One carbon pool by folate_Homo sapiens_hsa006700.68534064
87Protein export_Homo sapiens_hsa030600.68448449
88Purine metabolism_Homo sapiens_hsa002300.68140412
89Vitamin digestion and absorption_Homo sapiens_hsa049770.67946857
90Circadian rhythm_Homo sapiens_hsa047100.67644340
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67042985
92Wnt signaling pathway_Homo sapiens_hsa043100.66664561
93cAMP signaling pathway_Homo sapiens_hsa040240.66612360
94Pyruvate metabolism_Homo sapiens_hsa006200.66308800
95Glucagon signaling pathway_Homo sapiens_hsa049220.65322701
96TGF-beta signaling pathway_Homo sapiens_hsa043500.65127467
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64248932
98Glioma_Homo sapiens_hsa052140.64106937
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59900966
100beta-Alanine metabolism_Homo sapiens_hsa004100.59093338
101Bile secretion_Homo sapiens_hsa049760.58837723
102Tight junction_Homo sapiens_hsa045300.58183813
103Axon guidance_Homo sapiens_hsa043600.57285083
104Homologous recombination_Homo sapiens_hsa034400.53896139
105Hedgehog signaling pathway_Homo sapiens_hsa043400.53833746
106Inositol phosphate metabolism_Homo sapiens_hsa005620.52449558
107Colorectal cancer_Homo sapiens_hsa052100.49602386
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49425200
109Dorso-ventral axis formation_Homo sapiens_hsa043200.49347359
110p53 signaling pathway_Homo sapiens_hsa041150.49309569
111Fatty acid elongation_Homo sapiens_hsa000620.48966697
112Non-homologous end-joining_Homo sapiens_hsa034500.48850869
113ABC transporters_Homo sapiens_hsa020100.48571066
114Endometrial cancer_Homo sapiens_hsa052130.48411121
115Systemic lupus erythematosus_Homo sapiens_hsa053220.48263792
116Histidine metabolism_Homo sapiens_hsa003400.47194477
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46961441
118MAPK signaling pathway_Homo sapiens_hsa040100.46309812
119Biosynthesis of amino acids_Homo sapiens_hsa012300.45155313
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44991041
121MicroRNAs in cancer_Homo sapiens_hsa052060.44320460
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43849102
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.42497525
124Basal cell carcinoma_Homo sapiens_hsa052170.41218038
125Fructose and mannose metabolism_Homo sapiens_hsa000510.41005816
126Thyroid hormone synthesis_Homo sapiens_hsa049180.40970070
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39799481
128Huntingtons disease_Homo sapiens_hsa050160.36674681
129Dilated cardiomyopathy_Homo sapiens_hsa054140.36436377
130HIF-1 signaling pathway_Homo sapiens_hsa040660.34848313
131Ras signaling pathway_Homo sapiens_hsa040140.34804476
132Base excision repair_Homo sapiens_hsa034100.33107586
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32652732
134Choline metabolism in cancer_Homo sapiens_hsa052310.31823617
135Thyroid cancer_Homo sapiens_hsa052160.31467853
136Type I diabetes mellitus_Homo sapiens_hsa049400.31370908

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