FAM163B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.20207473
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.77357018
3locomotory exploration behavior (GO:0035641)6.50793267
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.35644713
5glutamate secretion (GO:0014047)6.07185243
6synaptic vesicle exocytosis (GO:0016079)6.00414808
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.88926495
8vocalization behavior (GO:0071625)5.87030862
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.85563753
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.82911493
11regulation of glutamate receptor signaling pathway (GO:1900449)5.64092845
12regulation of synaptic vesicle exocytosis (GO:2000300)5.35995552
13regulation of neuronal synaptic plasticity (GO:0048168)5.13486127
14protein localization to synapse (GO:0035418)5.10395106
15exploration behavior (GO:0035640)5.08228449
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.92300445
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.87711363
18regulation of synaptic vesicle transport (GO:1902803)4.83916679
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.77398594
20amino acid import (GO:0043090)4.72482842
21cerebellar granule cell differentiation (GO:0021707)4.72383859
22regulation of synapse structural plasticity (GO:0051823)4.71590397
23regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.63759537
24neurotransmitter secretion (GO:0007269)4.59892641
25neurotransmitter-gated ion channel clustering (GO:0072578)4.58771590
26synaptic transmission, glutamatergic (GO:0035249)4.50903703
27dendritic spine morphogenesis (GO:0060997)4.42238505
28layer formation in cerebral cortex (GO:0021819)4.36366260
29neuronal action potential propagation (GO:0019227)4.35179706
30proline transport (GO:0015824)4.33701818
31negative regulation of dendrite morphogenesis (GO:0050774)4.32856571
32positive regulation of synapse maturation (GO:0090129)4.32689277
33neuron cell-cell adhesion (GO:0007158)4.29855779
34long-term memory (GO:0007616)4.23929068
35glutamate receptor signaling pathway (GO:0007215)4.22397111
36positive regulation of membrane potential (GO:0045838)4.20123542
37regulation of voltage-gated calcium channel activity (GO:1901385)4.13716335
38regulation of excitatory postsynaptic membrane potential (GO:0060079)4.07480152
39regulation of synaptic plasticity (GO:0048167)4.06588510
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.06181559
41neuron-neuron synaptic transmission (GO:0007270)4.06005443
42regulation of dendritic spine morphogenesis (GO:0061001)4.04002621
43potassium ion homeostasis (GO:0055075)3.96554026
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95534021
45sodium ion export (GO:0071436)3.91385995
46cellular potassium ion homeostasis (GO:0030007)3.88612916
47regulation of postsynaptic membrane potential (GO:0060078)3.81064221
48potassium ion import (GO:0010107)3.80376019
49central nervous system myelination (GO:0022010)3.79791826
50axon ensheathment in central nervous system (GO:0032291)3.79791826
51long-term synaptic potentiation (GO:0060291)3.78443536
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.70097312
53gamma-aminobutyric acid transport (GO:0015812)3.68343008
54neurotransmitter transport (GO:0006836)3.65755575
55synaptic vesicle endocytosis (GO:0048488)3.64965933
56neuromuscular process controlling balance (GO:0050885)3.60461657
57regulation of neurotransmitter secretion (GO:0046928)3.59555023
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.58419574
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55496597
60activation of protein kinase A activity (GO:0034199)3.52732691
61cytoskeletal anchoring at plasma membrane (GO:0007016)3.52116637
62acidic amino acid transport (GO:0015800)3.50240303
63cell communication by electrical coupling (GO:0010644)3.44463980
64positive regulation of neurotransmitter secretion (GO:0001956)3.42615432
65positive regulation of dendritic spine morphogenesis (GO:0061003)3.41366041
66dendritic spine organization (GO:0097061)3.40731834
67positive regulation of dendritic spine development (GO:0060999)3.39961848
68neuron recognition (GO:0008038)3.39827785
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.39579836
70regulation of dendritic spine development (GO:0060998)3.39528579
71regulation of neurotransmitter levels (GO:0001505)3.38235858
72vesicle docking involved in exocytosis (GO:0006904)3.36274754
73regulation of vesicle fusion (GO:0031338)3.36079131
74neuromuscular synaptic transmission (GO:0007274)3.35213137
75behavioral defense response (GO:0002209)3.33435068
76behavioral fear response (GO:0001662)3.33435068
77L-amino acid import (GO:0043092)3.30628488
78positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28221979
79postsynaptic membrane organization (GO:0001941)3.28161610
80regulation of neurotransmitter transport (GO:0051588)3.26240273
81dendrite morphogenesis (GO:0048813)3.25538510
82auditory behavior (GO:0031223)3.24760594
83regulation of synapse maturation (GO:0090128)3.23139316
84neurotransmitter uptake (GO:0001504)3.23125301
85positive regulation of neurotransmitter transport (GO:0051590)3.22511084
86negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20504254
87regulation of synaptic transmission (GO:0050804)3.19188490
88positive regulation of synaptic transmission (GO:0050806)3.19042733
89transmission of nerve impulse (GO:0019226)3.18238258
90regulation of exocytosis (GO:0017157)3.17955091
91innervation (GO:0060384)3.17882594
92membrane depolarization (GO:0051899)3.17212531
93establishment of synaptic vesicle localization (GO:0097480)3.16700136
94synaptic vesicle transport (GO:0048489)3.16700136
95regulation of ARF protein signal transduction (GO:0032012)3.14932203
96gamma-aminobutyric acid signaling pathway (GO:0007214)3.14272374
97learning (GO:0007612)3.13853766
98axonal fasciculation (GO:0007413)3.13535854
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.13015934
100positive regulation of dendrite development (GO:1900006)3.10287810
101phosphorelay signal transduction system (GO:0000160)3.10078758
102response to auditory stimulus (GO:0010996)3.08985918
103vesicle docking (GO:0048278)3.08086848
104L-glutamate transport (GO:0015813)3.07571685
105neuromuscular process controlling posture (GO:0050884)3.07320872
106positive regulation of fibroblast migration (GO:0010763)3.06909817
107cell differentiation in hindbrain (GO:0021533)3.06692909
108fear response (GO:0042596)3.04959926
109chemosensory behavior (GO:0007635)3.03877859
110synaptic transmission (GO:0007268)3.02757244
111cellular sodium ion homeostasis (GO:0006883)3.02304276
112neuromuscular process (GO:0050905)2.99096630
113vesicle transport along microtubule (GO:0047496)2.99062646
114cerebellar Purkinje cell differentiation (GO:0021702)2.98540878
115neuronal ion channel clustering (GO:0045161)2.96552565
116membrane depolarization during action potential (GO:0086010)2.96148331
117glycine transport (GO:0015816)2.95932060
118intraspecies interaction between organisms (GO:0051703)2.95418287
119social behavior (GO:0035176)2.95418287
120membrane hyperpolarization (GO:0060081)2.93848501
121long term synaptic depression (GO:0060292)2.93214990
122G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92394420
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91104556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.47749034
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.22848095
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13886254
4GBX2_23144817_ChIP-Seq_PC3_Human3.12679560
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07230577
6* RARB_27405468_Chip-Seq_BRAIN_Mouse3.05462179
7REST_21632747_ChIP-Seq_MESCs_Mouse2.95882575
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.88106444
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.88106444
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75689534
11DROSHA_22980978_ChIP-Seq_HELA_Human2.70261581
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67463133
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59491282
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59137890
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54506879
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.53345784
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.49317631
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46364893
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.42444680
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35957303
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.34626909
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.32405566
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.32341112
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27849223
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.16971633
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11114378
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10374484
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88989922
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74034151
30AR_21572438_ChIP-Seq_LNCaP_Human1.73245568
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.71849940
32RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.55333811
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53600310
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49526778
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47622015
36SMAD4_21799915_ChIP-Seq_A2780_Human1.46473073
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.46151107
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46116996
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45687786
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33970996
41KDM2B_26808549_Chip-Seq_K562_Human1.32388539
42LXR_22292898_ChIP-Seq_THP-1_Human1.31024737
43SOX2_21211035_ChIP-Seq_LN229_Gbm1.28584981
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28187229
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27377243
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26729991
47* RING1B_27294783_Chip-Seq_NPCs_Mouse1.25318016
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24818248
49AR_19668381_ChIP-Seq_PC3_Human1.23441113
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23085620
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22323506
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17875277
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17381991
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14939870
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14320394
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12756744
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11207731
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10669741
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10356522
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10232101
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10062431
62* AR_25329375_ChIP-Seq_VCAP_Human1.09492361
63STAT3_23295773_ChIP-Seq_U87_Human1.09367507
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09349458
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.09128196
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.08475092
67OCT4_19829295_ChIP-Seq_ESCs_Human1.07747281
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07222462
69ZNF274_21170338_ChIP-Seq_K562_Hela1.05491028
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05245004
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.04943759
72P300_19829295_ChIP-Seq_ESCs_Human1.04794985
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.04193951
74* SMC4_20622854_ChIP-Seq_HELA_Human1.03607420
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02882473
76SMAD3_21741376_ChIP-Seq_HESCs_Human1.01886284
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01815004
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00465606
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00093266
80DPY_21335234_ChIP-Seq_ESCs_Mouse0.99443990
81CBX2_27304074_Chip-Seq_ESCs_Mouse0.99168017
82ARNT_22903824_ChIP-Seq_MCF-7_Human0.98485827
83TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98113780
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97978253
85TAF15_26573619_Chip-Seq_HEK293_Human0.97668025
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97611006
87RNF2_27304074_Chip-Seq_NSC_Mouse0.97330403
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96165481
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95758674
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94712664
91CTCF_27219007_Chip-Seq_Bcells_Human0.94212653
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93738846
93* TET1_21490601_ChIP-Seq_MESCs_Mouse0.92964869
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.92823066
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92802107
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92258037
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91858569
98AHR_22903824_ChIP-Seq_MCF-7_Human0.91569375
99TCF4_23295773_ChIP-Seq_U87_Human0.91105291
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91038896
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89729717
102* KLF4_19829295_ChIP-Seq_ESCs_Human0.89225526
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87632926
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.87422906
105* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87246116
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87170991
107RXR_22108803_ChIP-Seq_LS180_Human0.87119488
108PIAS1_25552417_ChIP-Seq_VCAP_Human0.86261093
109PRDM14_20953172_ChIP-Seq_ESCs_Human0.85984521
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85798976
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85114612
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85058946
113RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84452791
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84251501
115CREB1_26743006_Chip-Seq_LNCaP_Human0.84059113
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.83416156
117BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83280788
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82877353
119* P68_20966046_ChIP-Seq_HELA_Human0.82414243
120IGF1R_20145208_ChIP-Seq_DFB_Human0.81906691
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81716099
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80426149
123SMAD4_21741376_ChIP-Seq_ESCs_Human0.80076685
124KDM2B_26808549_Chip-Seq_DND41_Human0.78108891
125MYC_19915707_ChIP-ChIP_AK7_Human0.75377613
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.73617273
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70864900
128EGR1_19032775_ChIP-ChIP_M12_Human0.70426315
129GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70127021
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.69222240
131SA1_27219007_Chip-Seq_Bcells_Human0.68155083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity8.02827947
2MP0003880_abnormal_central_pattern4.83126176
3MP0003635_abnormal_synaptic_transmissio4.51239227
4MP0004270_analgesia3.92881730
5MP0002063_abnormal_learning/memory/cond3.63860342
6MP0009745_abnormal_behavioral_response3.53267464
7MP0002064_seizures3.32978778
8MP0002572_abnormal_emotion/affect_behav2.94452546
9MP0009046_muscle_twitch2.91350287
10MP0002822_catalepsy2.84520142
11MP0001968_abnormal_touch/_nociception2.77274250
12MP0001486_abnormal_startle_reflex2.65988763
13MP0002734_abnormal_mechanical_nocicepti2.57944270
14MP0005423_abnormal_somatic_nervous2.53573300
15MP0002272_abnormal_nervous_system2.50037565
16MP0001501_abnormal_sleep_pattern2.27980239
17MP0004858_abnormal_nervous_system2.24598890
18MP0002735_abnormal_chemical_nociception2.08450355
19MP0009780_abnormal_chondrocyte_physiolo2.06899379
20MP0001440_abnormal_grooming_behavior2.06859040
21MP0002736_abnormal_nociception_after2.06271695
22MP0004811_abnormal_neuron_physiology1.91775721
23MP0008569_lethality_at_weaning1.91265079
24MP0002733_abnormal_thermal_nociception1.88942659
25MP0001970_abnormal_pain_threshold1.86025390
26MP0003329_amyloid_beta_deposits1.82474672
27MP0000778_abnormal_nervous_system1.77301753
28MP0003879_abnormal_hair_cell1.75114977
29MP0002067_abnormal_sensory_capabilities1.75107170
30MP0003787_abnormal_imprinting1.74253620
31MP0002909_abnormal_adrenal_gland1.72139219
32MP0002557_abnormal_social/conspecific_i1.69563175
33MP0002184_abnormal_innervation1.66156345
34MP0004924_abnormal_behavior1.62249800
35MP0005386_behavior/neurological_phenoty1.62249800
36MP0000955_abnormal_spinal_cord1.55544187
37MP0005646_abnormal_pituitary_gland1.45254096
38MP0002882_abnormal_neuron_morphology1.42366557
39MP0004885_abnormal_endolymph1.41934910
40MP0002066_abnormal_motor_capabilities/c1.40382958
41MP0001984_abnormal_olfaction1.37356428
42MP0003633_abnormal_nervous_system1.35832294
43MP0003075_altered_response_to1.35454387
44MP0001905_abnormal_dopamine_level1.21061645
45MP0003122_maternal_imprinting1.16386997
46MP0003631_nervous_system_phenotype1.12957353
47MP0008961_abnormal_basal_metabolism1.11320151
48MP0001502_abnormal_circadian_rhythm1.10754208
49MP0002152_abnormal_brain_morphology1.10573238
50MP0005394_taste/olfaction_phenotype1.09612862
51MP0005499_abnormal_olfactory_system1.09612862
52MP0008872_abnormal_physiological_respon1.08602196
53MP0006276_abnormal_autonomic_nervous1.07741061
54MP0004142_abnormal_muscle_tone1.05862754
55MP0002638_abnormal_pupillary_reflex0.97612020
56MP0002069_abnormal_eating/drinking_beha0.96922219
57MP0001346_abnormal_lacrimal_gland0.96509451
58MP0008874_decreased_physiological_sensi0.95889613
59MP0001348_abnormal_lacrimal_gland0.93465855
60MP0000569_abnormal_digit_pigmentation0.91593120
61MP0002090_abnormal_vision0.89150336
62MP0001529_abnormal_vocalization0.88425510
63MP0005645_abnormal_hypothalamus_physiol0.87755530
64MP0001177_atelectasis0.87626460
65MP0004085_abnormal_heartbeat0.87159409
66MP0002229_neurodegeneration0.86784961
67MP0010234_abnormal_vibrissa_follicle0.85156180
68MP0004147_increased_porphyrin_level0.82679247
69MP0003690_abnormal_glial_cell0.79329465
70MP0003632_abnormal_nervous_system0.78190868
71MP0003634_abnormal_glial_cell0.77785561
72MP0001963_abnormal_hearing_physiology0.77152166
73MP0005551_abnormal_eye_electrophysiolog0.77132543
74MP0000751_myopathy0.76904153
75MP0001986_abnormal_taste_sensitivity0.76865696
76MP0000604_amyloidosis0.76211456
77MP0003283_abnormal_digestive_organ0.75289048
78MP0005535_abnormal_body_temperature0.75221698
79MP0006292_abnormal_olfactory_placode0.70972149
80MP0004510_myositis0.70234729
81MP0003137_abnormal_impulse_conducting0.68685011
82MP0005623_abnormal_meninges_morphology0.68227623
83MP0002752_abnormal_somatic_nervous0.68186447
84MP0004484_altered_response_of0.67712548
85MP0004215_abnormal_myocardial_fiber0.67638775
86MP0003172_abnormal_lysosome_physiology0.66549455
87MP0000920_abnormal_myelination0.65427279
88MP0005167_abnormal_blood-brain_barrier0.62955988
89MP0001188_hyperpigmentation0.61413820
90MP0003183_abnormal_peptide_metabolism0.60783633
91MP0000631_abnormal_neuroendocrine_gland0.60576380
92MP0004130_abnormal_muscle_cell0.60224102
93MP0004233_abnormal_muscle_weight0.60065369
94MP0003861_abnormal_nervous_system0.60021746
95MP0008877_abnormal_DNA_methylation0.59850610
96MP0005166_decreased_susceptibility_to0.57799104
97MP0004043_abnormal_pH_regulation0.56379614
98MP0001664_abnormal_digestion0.54714003
99MP0010769_abnormal_survival0.54231738
100MP0004742_abnormal_vestibular_system0.53953175
101MP0004145_abnormal_muscle_electrophysio0.53864295
102MP0000013_abnormal_adipose_tissue0.52612190
103MP0003123_paternal_imprinting0.51653553
104MP0010386_abnormal_urinary_bladder0.51571085
105MP0001485_abnormal_pinna_reflex0.51299480
106MP0002876_abnormal_thyroid_physiology0.51294896
107MP0002653_abnormal_ependyma_morphology0.50938912
108MP0000579_abnormal_nail_morphology0.50734980
109MP0010768_mortality/aging0.50653405
110MP0003956_abnormal_body_size0.50402241
111MP0001943_abnormal_respiration0.50164635
112MP0010770_preweaning_lethality0.49301004
113MP0002082_postnatal_lethality0.49301004
114MP0002873_normal_phenotype0.44810960
115MP0005410_abnormal_fertilization0.43730189
116MP0002169_no_abnormal_phenotype0.43236587
117MP0005409_darkened_coat_color0.42728913
118MP0000026_abnormal_inner_ear0.40933835

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.09466617
2Myokymia (HP:0002411)7.68267261
3Focal seizures (HP:0007359)6.11717331
4Visual hallucinations (HP:0002367)5.76224533
5Epileptic encephalopathy (HP:0200134)5.36119547
6Febrile seizures (HP:0002373)4.53079649
7Abnormality of the lower motor neuron (HP:0002366)4.44837188
8Atonic seizures (HP:0010819)4.32150351
9Absence seizures (HP:0002121)4.21938238
10Progressive cerebellar ataxia (HP:0002073)4.18369955
11Dialeptic seizures (HP:0011146)4.06224110
12Generalized tonic-clonic seizures (HP:0002069)4.02613180
13Action tremor (HP:0002345)3.77243303
14Impaired vibration sensation in the lower limbs (HP:0002166)3.58783105
15Limb dystonia (HP:0002451)3.53134471
16Hyperventilation (HP:0002883)3.51229971
17Cerebral hypomyelination (HP:0006808)3.49749632
18Poor eye contact (HP:0000817)3.48569539
19Ankle clonus (HP:0011448)3.47189785
20Supranuclear gaze palsy (HP:0000605)3.46997275
21Depression (HP:0000716)3.40183817
22Broad-based gait (HP:0002136)3.37987325
23Amblyopia (HP:0000646)3.36967766
24Papilledema (HP:0001085)3.21472972
25Gaze-evoked nystagmus (HP:0000640)3.18406819
26Mutism (HP:0002300)3.17534228
27Dysdiadochokinesis (HP:0002075)3.14725574
28Postural instability (HP:0002172)3.12577341
29Impaired social interactions (HP:0000735)3.12435026
30Abnormal social behavior (HP:0012433)3.12435026
31Urinary bladder sphincter dysfunction (HP:0002839)3.09583810
32Dysmetria (HP:0001310)3.06841451
33Akinesia (HP:0002304)2.95338462
34Abnormal eating behavior (HP:0100738)2.90912571
35Anxiety (HP:0000739)2.90144768
36Torticollis (HP:0000473)2.84376208
37Genetic anticipation (HP:0003743)2.82314010
38Focal dystonia (HP:0004373)2.75053034
39Annular pancreas (HP:0001734)2.74711653
40Excessive salivation (HP:0003781)2.73351960
41Drooling (HP:0002307)2.73351960
42Truncal ataxia (HP:0002078)2.70961878
43Hemiparesis (HP:0001269)2.69860532
44Urinary urgency (HP:0000012)2.67819387
45Stereotypic behavior (HP:0000733)2.66163957
46Impaired smooth pursuit (HP:0007772)2.61924698
47Bradykinesia (HP:0002067)2.61630936
48Peripheral hypomyelination (HP:0007182)2.57848201
49Intention tremor (HP:0002080)2.54746951
50Spastic gait (HP:0002064)2.53850127
51Impaired vibratory sensation (HP:0002495)2.52899779
52Ventricular fibrillation (HP:0001663)2.49423047
53Diminished motivation (HP:0000745)2.47623276
54Obstructive sleep apnea (HP:0002870)2.45985350
55Generalized myoclonic seizures (HP:0002123)2.45187452
56Megalencephaly (HP:0001355)2.44374354
57Abnormality of ocular smooth pursuit (HP:0000617)2.44065267
58Sleep apnea (HP:0010535)2.43418706
59Epileptiform EEG discharges (HP:0011182)2.42808466
60Amyotrophic lateral sclerosis (HP:0007354)2.42645811
61Hemiplegia (HP:0002301)2.41872235
62Absent speech (HP:0001344)2.37708192
63Craniofacial dystonia (HP:0012179)2.33567160
64Status epilepticus (HP:0002133)2.32376754
65EEG with generalized epileptiform discharges (HP:0011198)2.31711606
66Cerebral inclusion bodies (HP:0100314)2.29641519
67Abnormality of binocular vision (HP:0011514)2.25616443
68Diplopia (HP:0000651)2.25616443
69Hypsarrhythmia (HP:0002521)2.23520126
70Choreoathetosis (HP:0001266)2.23002672
71Pointed chin (HP:0000307)2.22738184
72Progressive inability to walk (HP:0002505)2.18260302
73Abnormality of the corticospinal tract (HP:0002492)2.16968904
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.16831619
75Ankyloglossia (HP:0010296)2.16728777
76Inability to walk (HP:0002540)2.16634057
77Neurofibrillary tangles (HP:0002185)2.16453989
78Scanning speech (HP:0002168)2.13971104
79CNS hypomyelination (HP:0003429)2.11035051
80Dysmetric saccades (HP:0000641)2.10585490
81Fetal akinesia sequence (HP:0001989)2.09729270
82Incomplete penetrance (HP:0003829)2.08588606
83Resting tremor (HP:0002322)2.07991216
84Bundle branch block (HP:0011710)2.07313794
85Lower limb muscle weakness (HP:0007340)2.06838491
86Termporal pattern (HP:0011008)2.04265906
87Insidious onset (HP:0003587)2.04265906
88Abnormality of saccadic eye movements (HP:0000570)2.03342529
89Morphological abnormality of the pyramidal tract (HP:0002062)2.03054222
90Rapidly progressive (HP:0003678)1.99953132
91Delusions (HP:0000746)1.96975873
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94546364
93Degeneration of the lateral corticospinal tracts (HP:0002314)1.94546364
94Memory impairment (HP:0002354)1.91913232
95Intellectual disability, profound (HP:0002187)1.91512693
96Spinal canal stenosis (HP:0003416)1.90665553
97Increased circulating renin level (HP:0000848)1.90425888
98Insomnia (HP:0100785)1.89650841
99Aplasia involving bones of the extremities (HP:0009825)1.87921725
100Aplasia involving bones of the upper limbs (HP:0009823)1.87921725
101Aplasia of the phalanges of the hand (HP:0009802)1.87921725
102Split foot (HP:0001839)1.86835163
103Apathy (HP:0000741)1.86802152
104Lower limb asymmetry (HP:0100559)1.86202212
105Gait ataxia (HP:0002066)1.85483732
106Clonus (HP:0002169)1.85080940
107Inappropriate behavior (HP:0000719)1.84585616
108Neoplasm of the heart (HP:0100544)1.84035950
109Lower limb amyotrophy (HP:0007210)1.83817512
110Abnormal EKG (HP:0003115)1.83645660
111Spastic tetraparesis (HP:0001285)1.81851280
112Abnormality of the periventricular white matter (HP:0002518)1.81646059
113Dementia (HP:0000726)1.81194076
114Rigidity (HP:0002063)1.79234924
115Generalized hypotonia (HP:0001290)1.78804152
116Polyphagia (HP:0002591)1.78333507
117Abnormality of salivation (HP:0100755)1.76832150
118Slow saccadic eye movements (HP:0000514)1.76051826
119Neuronal loss in central nervous system (HP:0002529)1.75888034
120Bronchomalacia (HP:0002780)1.74129990
121Tetraplegia (HP:0002445)1.74098152
122Hepatoblastoma (HP:0002884)1.71808082
123Heart block (HP:0012722)1.69366963
124Unsteady gait (HP:0002317)1.66034706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.72285089
2NTRK34.68637594
3MAP3K94.21640762
4DAPK22.87887805
5MARK12.76224191
6MINK12.66768172
7MAP3K42.65182475
8PRKD32.51970228
9PAK62.50996873
10KSR22.48073569
11MAP2K72.23626704
12GRK51.97953344
13NTRK21.96341408
14MAP2K41.88706773
15PRPF4B1.88299095
16CAMKK11.87821494
17KSR11.82992274
18DAPK11.82158348
19NTRK11.70206044
20MAP3K121.66491617
21ARAF1.59960469
22CDK51.56667759
23RIPK41.48858541
24CDK191.47994743
25TNIK1.47110279
26TYRO31.45896037
27MAP3K131.43414834
28STK381.42093598
29PLK21.37669061
30FES1.26657201
31MAP3K21.23654539
32PRKCG1.23005644
33TAOK11.18998646
34CAMK11.17433070
35SIK21.12324169
36LATS21.10442857
37CASK1.09641809
38MAPK131.08329436
39UHMK11.03178539
40PTK2B1.02379438
41CDK181.00716187
42RAF11.00010585
43CDK150.98901326
44CDK140.92405214
45ALK0.92276567
46PRKCH0.87761304
47CDK11A0.86560399
48CAMK2A0.86263137
49MARK20.83561342
50MAP3K70.82285558
51STK110.81767524
52PHKG10.80977135
53PHKG20.80977135
54PAK30.79326049
55PDK10.78303692
56MAP3K110.78010912
57SGK4940.72213021
58SGK2230.72213021
59NEK10.70698515
60CAMK40.70122084
61TESK10.70085108
62PNCK0.69508739
63RET0.68556029
64PINK10.68127961
65DYRK1A0.67956942
66CAMK2B0.67218114
67BRAF0.66646347
68MAP3K10.65848431
69CAMKK20.63906438
70PKN10.61852096
71PDPK10.61823990
72LMTK20.60134610
73OXSR10.60111379
74SGK10.59204237
75NME10.58784433
76SGK30.57466965
77SGK20.56238282
78BMPR20.54283082
79MOS0.51578392
80LIMK10.51055471
81GRK60.50374789
82CSNK1G20.49503330
83DAPK30.48478184
84RPS6KA30.48100494
85CCNB10.47064871
86MAPK70.45829174
87CAMK1G0.45751096
88BRSK10.43538072
89PRKCZ0.42590589
90PRKG20.42405529
91FER0.42294557
92MAPK120.41397918
93CAMK1D0.40960550
94MAPK100.40441692
95FYN0.39805158
96MAP2K10.38831892
97ROCK20.38024809
98DMPK0.35582533
99RIPK10.35332010
100MAP2K60.35233512
101CAMK2D0.34889339
102NEK60.34845107
103PRKCA0.34244876
104WNK10.33470083
105FGR0.33303216
106MAP3K60.33164011
107CDC42BPA0.31936194
108FGFR20.31424067
109TNK20.30715862
110PRKCE0.30518460
111SCYL20.28917084
112ERBB20.28299408
113ROCK10.28148720
114CAMK2G0.27749555
115TAOK20.27363699
116MAPK80.26669385
117IRAK20.25592258
118PRKCB0.24905814
119JAK20.22746753

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.44448598
2Nicotine addiction_Homo sapiens_hsa050333.38965859
3Olfactory transduction_Homo sapiens_hsa047403.00833567
4Long-term potentiation_Homo sapiens_hsa047202.79742857
5Circadian entrainment_Homo sapiens_hsa047132.78848804
6GABAergic synapse_Homo sapiens_hsa047272.61611820
7Glutamatergic synapse_Homo sapiens_hsa047242.61104202
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55168931
9Amphetamine addiction_Homo sapiens_hsa050312.51373180
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.37698019
11Morphine addiction_Homo sapiens_hsa050322.37109585
12Salivary secretion_Homo sapiens_hsa049702.20516829
13Dopaminergic synapse_Homo sapiens_hsa047282.12146895
14Insulin secretion_Homo sapiens_hsa049112.04299066
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95840220
16Gastric acid secretion_Homo sapiens_hsa049711.95795662
17Cholinergic synapse_Homo sapiens_hsa047251.94960321
18Vitamin B6 metabolism_Homo sapiens_hsa007501.89516889
19Oxytocin signaling pathway_Homo sapiens_hsa049211.77109505
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75088325
21Long-term depression_Homo sapiens_hsa047301.63328027
22Calcium signaling pathway_Homo sapiens_hsa040201.62938925
23GnRH signaling pathway_Homo sapiens_hsa049121.60537788
24Renin secretion_Homo sapiens_hsa049241.57183263
25Serotonergic synapse_Homo sapiens_hsa047261.50874990
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49827764
27Taste transduction_Homo sapiens_hsa047421.48178010
28Nitrogen metabolism_Homo sapiens_hsa009101.45682611
29Cocaine addiction_Homo sapiens_hsa050301.43974030
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40603912
31Glioma_Homo sapiens_hsa052141.33306991
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31783033
33Collecting duct acid secretion_Homo sapiens_hsa049661.31122690
34cAMP signaling pathway_Homo sapiens_hsa040241.30823343
35Gap junction_Homo sapiens_hsa045401.29035479
36Type II diabetes mellitus_Homo sapiens_hsa049301.16221491
37ErbB signaling pathway_Homo sapiens_hsa040121.15880625
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14644017
39Estrogen signaling pathway_Homo sapiens_hsa049151.14547950
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09067476
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08491492
42Axon guidance_Homo sapiens_hsa043601.08360597
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05869470
44Melanogenesis_Homo sapiens_hsa049161.05626629
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00167675
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.95667456
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.95369847
48Oocyte meiosis_Homo sapiens_hsa041140.94037952
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89932814
50Dorso-ventral axis formation_Homo sapiens_hsa043200.89026960
51Choline metabolism in cancer_Homo sapiens_hsa052310.83420412
52Cardiac muscle contraction_Homo sapiens_hsa042600.82048150
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80587563
54VEGF signaling pathway_Homo sapiens_hsa043700.78942077
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77260276
56Vibrio cholerae infection_Homo sapiens_hsa051100.76901949
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.73453751
58MAPK signaling pathway_Homo sapiens_hsa040100.71836411
59Pancreatic secretion_Homo sapiens_hsa049720.71818996
60Thyroid hormone synthesis_Homo sapiens_hsa049180.70365905
61Dilated cardiomyopathy_Homo sapiens_hsa054140.69441127
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67014287
63mTOR signaling pathway_Homo sapiens_hsa041500.66876147
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66016002
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65453341
66Ras signaling pathway_Homo sapiens_hsa040140.62898310
67Rap1 signaling pathway_Homo sapiens_hsa040150.61233893
68Glucagon signaling pathway_Homo sapiens_hsa049220.61204400
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60783992
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58565405
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.57296751
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57128774
73Non-small cell lung cancer_Homo sapiens_hsa052230.55657727
74Endocytosis_Homo sapiens_hsa041440.55564589
75Phototransduction_Homo sapiens_hsa047440.52360759
76Arginine biosynthesis_Homo sapiens_hsa002200.49451167
77Endometrial cancer_Homo sapiens_hsa052130.48994960
78Inositol phosphate metabolism_Homo sapiens_hsa005620.48727502
79Bile secretion_Homo sapiens_hsa049760.47905168
80Prion diseases_Homo sapiens_hsa050200.47895591
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45992125
82Arginine and proline metabolism_Homo sapiens_hsa003300.44796629
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44783992
84Wnt signaling pathway_Homo sapiens_hsa043100.43796935
85African trypanosomiasis_Homo sapiens_hsa051430.43385311
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42110736
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41776849
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41715872
89Type I diabetes mellitus_Homo sapiens_hsa049400.41699403
90Alcoholism_Homo sapiens_hsa050340.41504482
91Renal cell carcinoma_Homo sapiens_hsa052110.40946595
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40032200
93Fatty acid biosynthesis_Homo sapiens_hsa000610.38397161
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38272089
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38131895
96Insulin signaling pathway_Homo sapiens_hsa049100.37834400
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36934988
98Circadian rhythm_Homo sapiens_hsa047100.35968303
99Chemokine signaling pathway_Homo sapiens_hsa040620.34825822
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34177953
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33632563
102Ovarian steroidogenesis_Homo sapiens_hsa049130.32312495
103Histidine metabolism_Homo sapiens_hsa003400.31319460
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30578927
105Colorectal cancer_Homo sapiens_hsa052100.30532960
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.30244473
107HIF-1 signaling pathway_Homo sapiens_hsa040660.24176935
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22797886
109Mineral absorption_Homo sapiens_hsa049780.22717523
110Tight junction_Homo sapiens_hsa045300.20480890
111AMPK signaling pathway_Homo sapiens_hsa041520.19882531
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16632568
113Alzheimers disease_Homo sapiens_hsa050100.15940732

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