FAM161A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the FAM161 family. It is expressed mainly in the retina. Mouse studies suggested that this gene is involved in development of retinal progenitors during embryogenesis, and that its activity is restricted to mature photoreceptors after birth. Mutations in this gene cause autosomal recessive retinitis pigmentosa-28. Alternatively spliced transcript variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in visual perception (GO:0050908)9.68187827
2detection of light stimulus involved in sensory perception (GO:0050962)9.68187827
3photoreceptor cell maintenance (GO:0045494)9.62084907
4photoreceptor cell development (GO:0042461)9.29194428
5eye photoreceptor cell development (GO:0042462)9.00303332
6retinal rod cell development (GO:0046548)7.68743936
7GMP metabolic process (GO:0046037)7.46362576
8detection of visible light (GO:0009584)7.42428108
9phototransduction (GO:0007602)7.40003576
10phototransduction, visible light (GO:0007603)7.37470756
11detection of light stimulus (GO:0009583)7.27137639
12axonemal dynein complex assembly (GO:0070286)7.25583727
13protein-chromophore linkage (GO:0018298)7.05678501
14motile cilium assembly (GO:0044458)6.84860073
15cilium movement (GO:0003341)6.74206160
16* visual perception (GO:0007601)6.71983020
17* sensory perception of light stimulus (GO:0050953)6.65900502
18positive regulation of guanylate cyclase activity (GO:0031284)6.65527186
19epithelial cilium movement (GO:0003351)6.62496409
20eye photoreceptor cell differentiation (GO:0001754)6.60053401
21photoreceptor cell differentiation (GO:0046530)6.60053401
22axoneme assembly (GO:0035082)6.56681646
23cilium or flagellum-dependent cell motility (GO:0001539)6.50316303
24regulation of guanylate cyclase activity (GO:0031282)5.99386579
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.66086596
26sperm motility (GO:0030317)5.57506062
27retina development in camera-type eye (GO:0060041)5.49619981
28nonmotile primary cilium assembly (GO:0035058)5.39276011
29cellular response to light stimulus (GO:0071482)5.36000398
30detection of external stimulus (GO:0009581)5.22257962
31regulation of cilium movement (GO:0003352)5.18685481
32detection of abiotic stimulus (GO:0009582)5.14799313
33acrosome reaction (GO:0007340)4.75403477
34fusion of sperm to egg plasma membrane (GO:0007342)4.57622277
35multicellular organism reproduction (GO:0032504)4.54564653
36regulation of cGMP metabolic process (GO:0030823)4.47095260
37positive regulation of cGMP biosynthetic process (GO:0030828)4.19568669
38behavioral response to nicotine (GO:0035095)4.12616895
39sperm-egg recognition (GO:0035036)3.96427376
40spermatid development (GO:0007286)3.95393230
41regulation of cGMP biosynthetic process (GO:0030826)3.92813771
42* cilium organization (GO:0044782)3.89848512
43acrosome assembly (GO:0001675)3.87434462
44retina layer formation (GO:0010842)3.86800517
45intraciliary transport (GO:0042073)3.85599336
46cell wall macromolecule catabolic process (GO:0016998)3.83578342
47cell wall macromolecule metabolic process (GO:0044036)3.83578342
48cellular response to radiation (GO:0071478)3.70761409
49* cilium assembly (GO:0042384)3.68531727
50piRNA metabolic process (GO:0034587)3.67996139
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.67546735
52positive regulation of cGMP metabolic process (GO:0030825)3.64693338
53ventricular system development (GO:0021591)3.60728655
54binding of sperm to zona pellucida (GO:0007339)3.58206377
55plasma membrane fusion (GO:0045026)3.57116984
56sperm capacitation (GO:0048240)3.53178610
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50140413
58neuron fate determination (GO:0048664)3.48913279
59estrogen biosynthetic process (GO:0006703)3.48449852
60single fertilization (GO:0007338)3.48104403
61reproduction (GO:0000003)3.46516886
62cell-cell recognition (GO:0009988)3.46321280
63left/right axis specification (GO:0070986)3.44806068
64presynaptic membrane assembly (GO:0097105)3.44377424
65detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.42225773
66negative regulation of inclusion body assembly (GO:0090084)3.41814808
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41391458
68* sensory perception (GO:0007600)3.39163068
69cilium morphogenesis (GO:0060271)3.36543480
70receptor guanylyl cyclase signaling pathway (GO:0007168)3.36207703
71regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.33981793
72pyrimidine nucleobase catabolic process (GO:0006208)3.27785061
73energy coupled proton transport, down electrochemical gradient (GO:0015985)3.23470061
74ATP synthesis coupled proton transport (GO:0015986)3.23470061
75centriole replication (GO:0007099)3.23409824
76microtubule severing (GO:0051013)3.19470359
77protein localization to cilium (GO:0061512)3.16907983
78male meiosis (GO:0007140)3.16688921
79mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14264775
80negative regulation of DNA-dependent DNA replication (GO:2000104)3.13747604
81* cellular component assembly involved in morphogenesis (GO:0010927)3.11460283
82protein localization to synapse (GO:0035418)3.09135452
83presynaptic membrane organization (GO:0097090)3.06074563
84chromatin remodeling at centromere (GO:0031055)3.05791169
85adaptation of signaling pathway (GO:0023058)3.04079815
86fertilization (GO:0009566)3.00708367
87protein polyglutamylation (GO:0018095)2.96864600
88postsynaptic membrane organization (GO:0001941)2.95229277
89spermatogenesis (GO:0007283)2.92768733
90male meiosis I (GO:0007141)2.92713360
91microtubule bundle formation (GO:0001578)2.92167045
92cell morphogenesis involved in neuron differentiation (GO:0048667)2.91995393
93male gamete generation (GO:0048232)2.91578839
94GTP biosynthetic process (GO:0006183)2.90647783
95DNA methylation involved in gamete generation (GO:0043046)2.89403807
96neuron development (GO:0048666)2.87096646
97guanosine-containing compound biosynthetic process (GO:1901070)2.86122414
98DNA double-strand break processing (GO:0000729)2.84028198
99protein complex biogenesis (GO:0070271)2.83896394
100retinal ganglion cell axon guidance (GO:0031290)2.83527154
101CENP-A containing nucleosome assembly (GO:0034080)2.83361951
102regulation of voltage-gated calcium channel activity (GO:1901385)2.79856998
103gamete generation (GO:0007276)2.79303623
104regulation of microtubule-based movement (GO:0060632)2.79029122
105peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.78964491
106CDP-diacylglycerol biosynthetic process (GO:0016024)2.77784510
107response to light stimulus (GO:0009416)2.76693522
108replication fork processing (GO:0031297)2.76356520
109negative regulation of telomere maintenance (GO:0032205)2.75494308
110centriole assembly (GO:0098534)2.74034312
111water-soluble vitamin biosynthetic process (GO:0042364)2.73594250
112somite development (GO:0061053)2.72866218
113nucleoside diphosphate phosphorylation (GO:0006165)2.72011268
114prenylation (GO:0097354)2.71623802
115protein prenylation (GO:0018342)2.71623802
116otic vesicle formation (GO:0030916)2.71035969
117reciprocal meiotic recombination (GO:0007131)2.69620869
118reciprocal DNA recombination (GO:0035825)2.69620869
119protein-cofactor linkage (GO:0018065)2.68843819
120negative regulation of transcription regulatory region DNA binding (GO:2000678)2.68297719
121mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67930238
122mitochondrial respiratory chain complex I assembly (GO:0032981)2.67930238
123NADH dehydrogenase complex assembly (GO:0010257)2.67930238
124fucose catabolic process (GO:0019317)2.67042191
125L-fucose metabolic process (GO:0042354)2.67042191
126L-fucose catabolic process (GO:0042355)2.67042191
127nucleobase catabolic process (GO:0046113)2.66607857
128resolution of meiotic recombination intermediates (GO:0000712)2.66247294
129microtubule depolymerization (GO:0007019)2.66095562
130appendage development (GO:0048736)2.65931122
131limb development (GO:0060173)2.65931122
132histone exchange (GO:0043486)2.65679713
133recombinational repair (GO:0000725)2.65328508
134sequestering of actin monomers (GO:0042989)2.65276023
135short-term memory (GO:0007614)2.64947075
136hindbrain development (GO:0030902)2.64876385
137detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64477692
138mitochondrial respiratory chain complex assembly (GO:0033108)2.64334575
139chaperone-mediated protein transport (GO:0072321)2.63965469
140limb bud formation (GO:0060174)2.63861580
141electron transport chain (GO:0022900)2.62813403
142double-strand break repair via homologous recombination (GO:0000724)2.62028510
143cell proliferation in forebrain (GO:0021846)2.59942869
144protein neddylation (GO:0045116)2.59911950
145respiratory electron transport chain (GO:0022904)2.59435254
146regulation of telomere maintenance (GO:0032204)2.58257162
147neural tube formation (GO:0001841)2.57876376
148regulation of DNA endoreduplication (GO:0032875)2.56447525
149spinal cord motor neuron differentiation (GO:0021522)2.55933741
150regulation of meiosis I (GO:0060631)2.55113644
151protein K6-linked ubiquitination (GO:0085020)2.55045223
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54480893
153respiratory chain complex IV assembly (GO:0008535)2.54171022
154neuron cell-cell adhesion (GO:0007158)2.53202644
155spliceosomal complex assembly (GO:0000245)2.52252622
156regulation of timing of cell differentiation (GO:0048505)2.49966479
157kidney morphogenesis (GO:0060993)2.49511685
158response to pheromone (GO:0019236)2.48544082
159smoothened signaling pathway (GO:0007224)2.45497255
160regulation of nuclear cell cycle DNA replication (GO:0033262)2.44953393
161positive regulation of oligodendrocyte differentiation (GO:0048714)2.44156898
162nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.41176487
163synapsis (GO:0007129)2.39112041
164negative regulation of translation, ncRNA-mediated (GO:0040033)2.38936513
165regulation of translation, ncRNA-mediated (GO:0045974)2.38936513
166negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.38936513
167regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.37188185
168regulation of mitotic spindle checkpoint (GO:1903504)2.37188185
169forebrain neuron differentiation (GO:0021879)2.36546915
170maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.36358040
171nephron tubule morphogenesis (GO:0072078)2.36180025
172nephron epithelium morphogenesis (GO:0072088)2.36180025
173transmission of nerve impulse (GO:0019226)2.34241075
174exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.32780082
175regulation of development, heterochronic (GO:0040034)2.31878883
176cytochrome complex assembly (GO:0017004)2.31390147
177regulation of rhodopsin mediated signaling pathway (GO:0022400)13.2052327
178rhodopsin mediated signaling pathway (GO:0016056)12.9886774
179retinal cone cell development (GO:0046549)10.8276603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.20980446
2ZNF274_21170338_ChIP-Seq_K562_Hela3.16978512
3GBX2_23144817_ChIP-Seq_PC3_Human2.80362785
4* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63722410
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.62815234
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52198505
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43837143
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38954100
9EZH2_22144423_ChIP-Seq_EOC_Human2.37140228
10EWS_26573619_Chip-Seq_HEK293_Human2.35950473
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.34979489
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19166164
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17021195
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06722279
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.04349939
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98541832
17IGF1R_20145208_ChIP-Seq_DFB_Human1.97645151
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96391832
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.95739676
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.95322157
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95107542
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91778386
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90673210
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.83349007
25* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.79373068
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78066630
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74927513
28RNF2_27304074_Chip-Seq_NSC_Mouse1.73485029
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71725015
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70533232
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70108743
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69886644
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67401040
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62224446
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61144768
36MYC_18940864_ChIP-ChIP_HL60_Human1.60726447
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.59386187
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.57555436
39ER_23166858_ChIP-Seq_MCF-7_Human1.56066423
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.55552664
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52759623
42P300_19829295_ChIP-Seq_ESCs_Human1.51698640
43SMAD4_21799915_ChIP-Seq_A2780_Human1.51616160
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51200347
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51116210
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48383980
47TAF15_26573619_Chip-Seq_HEK293_Human1.48355048
48ELK1_19687146_ChIP-ChIP_HELA_Human1.48311375
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47926291
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44675605
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43611614
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.41584518
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39471147
54FUS_26573619_Chip-Seq_HEK293_Human1.39041945
55IRF1_19129219_ChIP-ChIP_H3396_Human1.37306565
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35135270
57* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35041923
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33878067
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.33638122
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33498988
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32717361
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.32100759
63MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31329835
64* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31277887
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30917165
66TBL1_22424771_ChIP-Seq_293T_Human1.30322974
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.30108196
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.29996133
69AR_21572438_ChIP-Seq_LNCaP_Human1.29670158
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.28959614
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28654786
72* REST_21632747_ChIP-Seq_MESCs_Mouse1.28244992
73TP53_22573176_ChIP-Seq_HFKS_Human1.28181690
74KDM2B_26808549_Chip-Seq_REH_Human1.27426452
75AR_25329375_ChIP-Seq_VCAP_Human1.27195180
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.27078562
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26491954
78P53_22387025_ChIP-Seq_ESCs_Mouse1.25940391
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25594584
80P300_18555785_Chip-Seq_ESCs_Mouse1.25078148
81STAT3_23295773_ChIP-Seq_U87_Human1.24535076
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.23795861
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23784808
84STAT1_17558387_ChIP-Seq_HELA_Human1.23623490
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22569417
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22569417
87KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22287039
88SOX2_18555785_Chip-Seq_ESCs_Mouse1.21945236
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21590660
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20801721
91TCF4_23295773_ChIP-Seq_U87_Human1.20395298
92ZFX_18555785_Chip-Seq_ESCs_Mouse1.20100654
93KLF4_18555785_Chip-Seq_ESCs_Mouse1.20004069
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19979218
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19685152
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19610061
97GF1_26923725_Chip-Seq_HPCs_Mouse1.19458093
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.18749273
99OCT4_18555785_Chip-Seq_ESCs_Mouse1.18085892
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15542590
101FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15432759
102ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15357373
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15156701
104SOX2_19829295_ChIP-Seq_ESCs_Human1.15032617
105NANOG_19829295_ChIP-Seq_ESCs_Human1.15032617
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.15004395
107* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14835469
108STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14148553
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13931216
110LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13020119
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12017229
112SOX2_16153702_ChIP-ChIP_HESCs_Human1.11940989
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.11510240
114ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11420229
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11357571
116RUNX2_22187159_ChIP-Seq_PCA_Human1.11127923
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.10388196
118TCF4_22108803_ChIP-Seq_LS180_Human1.10022876
119RNF2_27304074_Chip-Seq_ESCs_Mouse1.09720590
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09584903
121NMYC_18555785_Chip-Seq_ESCs_Mouse1.09506843
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08110159
123BCAT_22108803_ChIP-Seq_LS180_Human1.07144288
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06918998
125PU1_27457419_Chip-Seq_LIVER_Mouse1.06255824
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05922323
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05370578
128CTCF_18555785_Chip-Seq_ESCs_Mouse1.04801475
129SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04617311
130CBP_20019798_ChIP-Seq_JUKART_Human1.04481068
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04481068
132P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04288017
133GF1B_26923725_Chip-Seq_HPCs_Mouse1.04269170
134EED_16625203_ChIP-ChIP_MESCs_Mouse1.03170638
135FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02689693
136VDR_23849224_ChIP-Seq_CD4+_Human1.02311491
137CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01718282
138JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01234864
139FOXA1_25329375_ChIP-Seq_VCAP_Human1.00782085
140FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00782085
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.94396442
142ETS1_20019798_ChIP-Seq_JURKAT_Human0.94231969
143JUN_21703547_ChIP-Seq_K562_Human0.94141659
144ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91750635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog8.55925561
2MP0003011_delayed_dark_adaptation8.40285126
3MP0005253_abnormal_eye_physiology5.82233578
4MP0006072_abnormal_retinal_apoptosis5.68812680
5MP0003950_abnormal_plasma_membrane4.94074347
6MP0005410_abnormal_fertilization4.07699994
7MP0005195_abnormal_posterior_eye3.46329785
8MP0002638_abnormal_pupillary_reflex3.16412164
9MP0001324_abnormal_eye_pigmentation3.10054213
10MP0005391_vision/eye_phenotype2.97593496
11MP0002653_abnormal_ependyma_morphology2.37874901
12MP0003787_abnormal_imprinting2.34713998
13MP0002090_abnormal_vision2.27552098
14MP0002229_neurodegeneration2.27130304
15MP0002938_white_spotting2.24425955
16MP0000566_synostosis2.12939797
17MP0005423_abnormal_somatic_nervous2.09934601
18MP0006292_abnormal_olfactory_placode2.04527173
19MP0000569_abnormal_digit_pigmentation1.98829679
20MP0001984_abnormal_olfaction1.93781050
21MP0003121_genomic_imprinting1.93455347
22MP0002752_abnormal_somatic_nervous1.92828079
23MP0003698_abnormal_male_reproductive1.84075484
24MP0003136_yellow_coat_color1.77202793
25MP0001986_abnormal_taste_sensitivity1.75958020
26MP0001764_abnormal_homeostasis1.72045600
27MP0003122_maternal_imprinting1.71116363
28MP0009379_abnormal_foot_pigmentation1.66527360
29MP0003890_abnormal_embryonic-extraembry1.59458449
30MP0001929_abnormal_gametogenesis1.54189916
31MP0002837_dystrophic_cardiac_calcinosis1.47895349
32MP0001485_abnormal_pinna_reflex1.42732308
33MP0002735_abnormal_chemical_nociception1.41526972
34MP0000372_irregular_coat_pigmentation1.41266985
35MP0003195_calcinosis1.39866339
36MP0002751_abnormal_autonomic_nervous1.36657250
37MP0002882_abnormal_neuron_morphology1.31403786
38MP0010094_abnormal_chromosome_stability1.29831447
39MP0008004_abnormal_stomach_pH1.28546161
40MP0000049_abnormal_middle_ear1.26211633
41MP0001502_abnormal_circadian_rhythm1.26057105
42MP0003119_abnormal_digestive_system1.19637790
43MP0003880_abnormal_central_pattern1.14966191
44MP0003938_abnormal_ear_development1.14338341
45MP0005670_abnormal_white_adipose1.12925187
46MP0002233_abnormal_nose_morphology1.11308177
47MP0008872_abnormal_physiological_respon1.11287733
48MP0002184_abnormal_innervation1.10687077
49MP0001188_hyperpigmentation1.09436524
50MP0001905_abnormal_dopamine_level1.08686635
51MP0003635_abnormal_synaptic_transmissio1.08306225
52MP0005377_hearing/vestibular/ear_phenot1.06404267
53MP0003878_abnormal_ear_physiology1.06404267
54MP0000955_abnormal_spinal_cord1.06264917
55MP0005174_abnormal_tail_pigmentation1.04666087
56MP0009046_muscle_twitch1.04095935
57MP0005394_taste/olfaction_phenotype1.03971641
58MP0005499_abnormal_olfactory_system1.03971641
59MP0008789_abnormal_olfactory_epithelium1.03295011
60MP0004019_abnormal_vitamin_homeostasis1.02453212
61MP0008877_abnormal_DNA_methylation1.02451096
62MP0003283_abnormal_digestive_organ1.01786182
63MP0002210_abnormal_sex_determination1.00032930
64MP0005645_abnormal_hypothalamus_physiol0.99689675
65MP0001970_abnormal_pain_threshold0.97932681
66MP0002161_abnormal_fertility/fecundity0.97834039
67MP0002733_abnormal_thermal_nociception0.96847927
68MP0004885_abnormal_endolymph0.94763735
69MP0001486_abnormal_startle_reflex0.94024805
70MP0002095_abnormal_skin_pigmentation0.93815178
71MP0002102_abnormal_ear_morphology0.92851499
72MP0004145_abnormal_muscle_electrophysio0.91430920
73MP0003755_abnormal_palate_morphology0.91312551
74MP0010030_abnormal_orbit_morphology0.90312973
75MP0004742_abnormal_vestibular_system0.90227634
76MP0004233_abnormal_muscle_weight0.89979016
77MP0002822_catalepsy0.89169642
78MP0003634_abnormal_glial_cell0.88935517
79MP0008875_abnormal_xenobiotic_pharmacok0.87944488
80MP0010386_abnormal_urinary_bladder0.87738679
81MP0003861_abnormal_nervous_system0.86969489
82MP0002272_abnormal_nervous_system0.86782163
83MP0005197_abnormal_uvea_morphology0.86169567
84MP0005646_abnormal_pituitary_gland0.84665731
85MP0001963_abnormal_hearing_physiology0.83412173
86MP0004270_analgesia0.83113563
87MP0001286_abnormal_eye_development0.78313480
88MP0002734_abnormal_mechanical_nocicepti0.76738543
89MP0000631_abnormal_neuroendocrine_gland0.76550552
90MP0000026_abnormal_inner_ear0.75490444
91MP0008995_early_reproductive_senescence0.73844809
92MP0000653_abnormal_sex_gland0.73817941
93MP0001145_abnormal_male_reproductive0.72282347
94MP0004782_abnormal_surfactant_physiolog0.66578548
95MP0002160_abnormal_reproductive_system0.65972107
96MP0002067_abnormal_sensory_capabilities0.64681019
97MP0001346_abnormal_lacrimal_gland0.63818958
98MP0002928_abnormal_bile_duct0.60473141
99MP0001968_abnormal_touch/_nociception0.57692204
100MP0002277_abnormal_respiratory_mucosa0.56066801
101MP0005409_darkened_coat_color0.54987694
102MP0004381_abnormal_hair_follicle0.54500709
103MP0008058_abnormal_DNA_repair0.53796748
104MP0004142_abnormal_muscle_tone0.53350246
105MP0002332_abnormal_exercise_endurance0.51921256
106MP0002572_abnormal_emotion/affect_behav0.51815791
107MP0003718_maternal_effect0.51322658
108MP0000778_abnormal_nervous_system0.49489980
109MP0002064_seizures0.48449275
110MP0005171_absent_coat_pigmentation0.47034098
111MP0006276_abnormal_autonomic_nervous0.46531418
112MP0002127_abnormal_cardiovascular_syste0.43978185
113MP0004133_heterotaxia0.43326995
114MP0005386_behavior/neurological_phenoty0.42838807
115MP0004924_abnormal_behavior0.42838807
116MP0005623_abnormal_meninges_morphology0.40792983
117MP0000920_abnormal_myelination0.38862450
118MP0005084_abnormal_gallbladder_morpholo0.38723531
119MP0001661_extended_life_span0.38351775
120MP0009745_abnormal_behavioral_response0.37634668
121MP0002557_abnormal_social/conspecific_i0.36478989
122MP0001177_atelectasis0.35889562
123MP0002876_abnormal_thyroid_physiology0.35183573
124MP0003786_premature_aging0.34806627
125MP0001529_abnormal_vocalization0.34745354
126MP0005389_reproductive_system_phenotype0.34561780
127MP0002152_abnormal_brain_morphology0.33628458
128MP0002697_abnormal_eye_size0.32843633
129MP0003943_abnormal_hepatobiliary_system0.30541064
130MP0001440_abnormal_grooming_behavior0.30519847
131MP0002736_abnormal_nociception_after0.30433540
132MP0002063_abnormal_learning/memory/cond0.29347188
133MP0003937_abnormal_limbs/digits/tail_de0.29180766
134MP0003646_muscle_fatigue0.29020576
135MP0008569_lethality_at_weaning0.28704132
136MP0002234_abnormal_pharynx_morphology0.28025670
137MP0001293_anophthalmia0.27954796

Predicted human phenotypes

RankGene SetZ-score
1* Bony spicule pigmentary retinopathy (HP:0007737)8.80144797
2Abnormal rod and cone electroretinograms (HP:0008323)8.18806617
3Absent rod-and cone-mediated responses on ERG (HP:0007688)8.08907437
4Dyschromatopsia (HP:0007641)7.65320909
5Chorioretinal atrophy (HP:0000533)6.87643300
6Pigmentary retinal degeneration (HP:0001146)6.78895010
7Central scotoma (HP:0000603)6.66901861
8Abnormality of macular pigmentation (HP:0008002)6.63727983
9Attenuation of retinal blood vessels (HP:0007843)6.48912680
10Decreased central vision (HP:0007663)6.20421132
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.10369633
12Pendular nystagmus (HP:0012043)6.07546140
13Scotoma (HP:0000575)5.81477212
14Abolished electroretinogram (ERG) (HP:0000550)5.61199744
15Dynein arm defect of respiratory motile cilia (HP:0012255)5.48226678
16Absent/shortened dynein arms (HP:0200106)5.48226678
17Abnormal respiratory motile cilium physiology (HP:0012261)5.42223281
18Abnormal ciliary motility (HP:0012262)5.10273842
19Abnormal respiratory epithelium morphology (HP:0012253)4.74381318
20Abnormal respiratory motile cilium morphology (HP:0005938)4.74381318
21Cone-rod dystrophy (HP:0000548)4.59547474
22* Photophobia (HP:0000613)4.58236756
23Increased corneal curvature (HP:0100692)4.48290598
24Keratoconus (HP:0000563)4.48290598
25* Type II diabetes mellitus (HP:0005978)4.28653187
26Severe visual impairment (HP:0001141)4.18006394
27Rhinitis (HP:0012384)4.12508287
28Macular degeneration (HP:0000608)4.07518331
29* Retinitis pigmentosa (HP:0000510)3.93586351
30Vitreoretinal degeneration (HP:0000655)3.90060274
31Choroideremia (HP:0001139)3.87325552
32Medial flaring of the eyebrow (HP:0010747)3.37171205
33Abnormality of the labia minora (HP:0012880)3.32991015
34Congenital primary aphakia (HP:0007707)3.25849103
35Gait imbalance (HP:0002141)3.25051968
36Chronic bronchitis (HP:0004469)3.12731088
37Decreased electroretinogram (ERG) amplitude (HP:0000654)3.11850331
38Pancreatic fibrosis (HP:0100732)3.02989250
39True hermaphroditism (HP:0010459)3.01397451
40Nephrogenic diabetes insipidus (HP:0009806)2.93821427
41* Constricted visual fields (HP:0001133)2.71105697
42Congenital sensorineural hearing impairment (HP:0008527)2.70898530
43Acute necrotizing encephalopathy (HP:0006965)2.69130656
44Posterior subcapsular cataract (HP:0007787)2.66116878
45Colon cancer (HP:0003003)2.59653000
46Optic nerve hypoplasia (HP:0000609)2.59437275
47Type II lissencephaly (HP:0007260)2.51779773
48Vaginal atresia (HP:0000148)2.50063661
49Genital tract atresia (HP:0001827)2.49077618
50Nephronophthisis (HP:0000090)2.48774357
51Poor coordination (HP:0002370)2.46650036
52* Optic disc pallor (HP:0000543)2.44770047
53Intestinal atresia (HP:0011100)2.44012395
54Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.43714974
55Volvulus (HP:0002580)2.42206876
56Acute encephalopathy (HP:0006846)2.36663595
57Progressive visual loss (HP:0000529)2.35334322
58Progressive macrocephaly (HP:0004481)2.34876127
59Mitochondrial inheritance (HP:0001427)2.31985008
60Pancreatic cysts (HP:0001737)2.31571405
61Molar tooth sign on MRI (HP:0002419)2.30163547
62Abnormality of midbrain morphology (HP:0002418)2.30163547
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.27305745
64Bronchiectasis (HP:0002110)2.25006902
65Aplasia/Hypoplasia of the lens (HP:0008063)2.24820934
66Abnormal mitochondria in muscle tissue (HP:0008316)2.24214192
67Recurrent sinusitis (HP:0011108)2.22940581
68Gastrointestinal atresia (HP:0002589)2.20269328
69Infertility (HP:0000789)2.19529590
70Meckel diverticulum (HP:0002245)2.13583435
71Increased hepatocellular lipid droplets (HP:0006565)2.12328022
72Retinal atrophy (HP:0001105)2.11786511
73Abnormality of the renal cortex (HP:0011035)2.10692627
74Abnormality of the renal medulla (HP:0100957)2.08993087
75Lissencephaly (HP:0001339)2.08821696
76Abnormality of the ileum (HP:0001549)2.08403681
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.07410319
78Increased CSF lactate (HP:0002490)2.07101717
79Birth length less than 3rd percentile (HP:0003561)2.06733795
80Oligodactyly (hands) (HP:0001180)2.02291691
81Patellar aplasia (HP:0006443)2.02004252
82Congenital stationary night blindness (HP:0007642)11.4562894
83Lipid accumulation in hepatocytes (HP:0006561)1.99317497
84Congenital, generalized hypertrichosis (HP:0004540)1.99271306
85Anophthalmia (HP:0000528)1.97611777
86Limb dystonia (HP:0002451)1.97016745
87Bilateral microphthalmos (HP:0007633)1.95777738
88Rib fusion (HP:0000902)1.95114951
89Esophageal atresia (HP:0002032)1.91871579
90Cystic liver disease (HP:0006706)1.90833759
91Chromsome breakage (HP:0040012)1.90686474
92Triphalangeal thumb (HP:0001199)1.90230377
93Hyperventilation (HP:0002883)1.89723319
94Tubular atrophy (HP:0000092)1.89226407
95Aplasia/Hypoplasia of the patella (HP:0006498)1.85578601
96* Wide nasal bridge (HP:0000431)1.84803741
97Hepatocellular necrosis (HP:0001404)1.84767349
98Methylmalonic acidemia (HP:0002912)1.82741200
99Subcapsular cataract (HP:0000523)1.82466204
100Focal motor seizures (HP:0011153)1.82338407
101Narrow forehead (HP:0000341)1.81772905
102Abnormality of chromosome stability (HP:0003220)1.81348491
103Dandy-Walker malformation (HP:0001305)1.80993576
104Furrowed tongue (HP:0000221)1.80317393
105Broad-based gait (HP:0002136)1.79888819
106Inability to walk (HP:0002540)1.77038031
107Congenital hepatic fibrosis (HP:0002612)1.76012586
108Aplasia/Hypoplasia of the tibia (HP:0005772)1.75502370
109Hyperglycinemia (HP:0002154)1.74729983
110Sloping forehead (HP:0000340)1.74249651
111Postaxial foot polydactyly (HP:0001830)1.74170175
112Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69738258
113Hypoplasia of the pons (HP:0012110)1.68684078
114Astigmatism (HP:0000483)1.68427986
115Hepatic necrosis (HP:0002605)1.67868971
116Pachygyria (HP:0001302)1.67144321
117Tubulointerstitial nephritis (HP:0001970)1.66740037
118Chronic hepatic failure (HP:0100626)1.54309386
119Sclerocornea (HP:0000647)1.53167753
120Abnormality of the fovea (HP:0000493)1.52102530
121Septo-optic dysplasia (HP:0100842)1.52062529
122Median cleft lip (HP:0000161)1.48769447
123Postaxial hand polydactyly (HP:0001162)1.48657992
124Nasal polyposis (HP:0100582)1.48116891
125Anencephaly (HP:0002323)1.46331696
126Recurrent otitis media (HP:0000403)1.45623026
127Broad foot (HP:0001769)1.44733259
128Hypoplasia of the fovea (HP:0007750)1.43528839
129Aplasia/Hypoplasia of the fovea (HP:0008060)1.43528839
130* Optic atrophy (HP:0000648)1.42968267
131Severe Myopia (HP:0011003)1.41453414
132Supernumerary spleens (HP:0009799)1.38751378
133Male pseudohermaphroditism (HP:0000037)1.37829876
134Bronchitis (HP:0012387)1.29931615
135Occipital encephalocele (HP:0002085)1.29418624
136Preaxial hand polydactyly (HP:0001177)1.28085285
137Epileptic encephalopathy (HP:0200134)1.27576413
138Asthma (HP:0002099)1.26791607
139Chorioretinal coloboma (HP:0000567)1.24396730
140Specific learning disability (HP:0001328)1.22148609
141Aganglionic megacolon (HP:0002251)1.19689968
142Male infertility (HP:0003251)1.19153660
143Hypodontia (HP:0000668)1.18026961
144Stage 5 chronic kidney disease (HP:0003774)1.17864966
145Chronic sinusitis (HP:0011109)1.17340528
146Absent septum pellucidum (HP:0001331)1.12335978
147Horizontal nystagmus (HP:0000666)1.12301930
148Cerebellar dysplasia (HP:0007033)1.11142174
149Left ventricular hypertrophy (HP:0001712)1.10853306
150Oculomotor apraxia (HP:0000657)1.10670455
151Progressive cerebellar ataxia (HP:0002073)1.10268458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK16.90228771
2PBK5.78923589
3PNCK3.09032467
4WNK32.97760316
5PRKD32.73417112
6PINK12.58334666
7CASK2.37112491
8AKT32.29002907
9PDK42.25175108
10PDK32.25175108
11STK392.21710469
12PDK22.17466894
13IRAK22.10733608
14MAPK151.94753280
15VRK21.93322739
16MAP4K21.87156096
17CDC71.84537785
18TAF11.75722242
19WEE11.69093277
20MAP3K91.68891690
21MAP3K41.59519082
22PRPF4B1.52729980
23NEK61.52035662
24STK38L1.38737093
25TRIM281.37675639
26ICK1.35447964
27WNK41.35056302
28STK381.34721230
29TLK11.32856279
30NEK11.30178913
31INSRR1.29125676
32CDK31.28973674
33SGK2231.28313731
34SGK4941.28313731
35BRSK21.26084220
36ACVR1B1.25209169
37TESK11.21190868
38TSSK61.16479622
39BCR1.15249763
40PKN11.15063856
41BUB11.14550908
42PAK31.13919852
43CSNK1G21.12681654
44WNK11.12551703
45CSNK1G11.06558715
46PASK1.06360134
47TAOK31.04715153
48IRAK11.04082548
49STK161.02877773
50BMPR1B0.99127839
51CSNK1G30.98287079
52TNIK0.96486572
53BRD40.93344906
54BMPR20.91422426
55SGK20.89839774
56MINK10.89006120
57DYRK1A0.88975914
58PLK10.88701532
59OXSR10.86227850
60EPHA40.84734372
61MAPKAPK50.84384418
62MKNK20.81515638
63PLK40.81104020
64MAPK70.80228160
65NTRK30.79358524
66TTK0.77559122
67ADRBK10.76926589
68EPHB20.74095188
69ZAK0.72693585
70DYRK1B0.72635794
71CAMK1G0.72348844
72PLK20.72079668
73FGFR20.71130662
74CSNK1A1L0.70539958
75CDK120.69917312
76TGFBR10.69072545
77PRKD20.68272469
78CAMK2D0.67678550
79CLK10.67655453
80BCKDK0.66639355
81MARK10.66422936
82ATR0.66040569
83NUAK10.65661785
84VRK10.62051646
85CAMK2A0.61870744
86MAPK130.61734130
87YES10.61108848
88NME10.60778062
89NLK0.60431163
90PTK2B0.60424623
91BRAF0.59498029
92GRK70.58479237
93ATM0.57765259
94PRKAA20.57480828
95MUSK0.57017970
96CDK90.54740884
97CSNK1D0.54098070
98PRKAA10.52935916
99STK30.52890029
100GRK50.51609709
101CDK190.50883829
102RPS6KA50.49741188
103PLK30.48881345
104CSNK1E0.48623673
105AURKB0.48001482
106MARK20.47923577
107TAOK20.47482345
108BRSK10.45947111
109CHEK20.45614837
110PRKCE0.44372656
111FRK0.44338735
112MAP2K70.43864645
113AURKA0.42758215
114PAK60.42600111
115MAPK120.40882123
116PRKG10.40836188
117CCNB10.40658738
118CSNK1A10.40532336
119PRKCG0.40158065
120PRKCZ0.40063639
121DYRK20.39657700
122ERBB30.39253191
123TXK0.38730483
124PRKACA0.38626942
125PIK3CA0.37999876
126NEK20.37439922
127PRKACB0.37348919
128DAPK20.36840200
129PHKG20.36730873
130PHKG10.36730873
131SRPK10.36316720
132NTRK20.36281059
133DYRK30.35960147
134CSNK2A20.34994927
135SIK30.34468850
136MKNK10.34321561
137UHMK10.33960133
138PRKCB0.31357331
139HIPK20.30701184
140GSK3B0.30394085
141ADRBK20.30319986
142IRAK30.30162540
143TIE10.29949767
144EIF2AK20.29527274
145CAMK2B0.27952052

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.89902519
2Parkinsons disease_Homo sapiens_hsa050122.66649839
3Ribosome_Homo sapiens_hsa030102.36471263
4Mismatch repair_Homo sapiens_hsa034302.28285509
5RNA polymerase_Homo sapiens_hsa030202.12706358
6Phototransduction_Homo sapiens_hsa0474414.5722758
7Non-homologous end-joining_Homo sapiens_hsa034501.89437816
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85942253
9Butanoate metabolism_Homo sapiens_hsa006501.77651180
10Propanoate metabolism_Homo sapiens_hsa006401.59629948
11Nitrogen metabolism_Homo sapiens_hsa009101.54982165
12Proteasome_Homo sapiens_hsa030501.54619729
13DNA replication_Homo sapiens_hsa030301.52653317
14Synaptic vesicle cycle_Homo sapiens_hsa047211.40836050
15Nucleotide excision repair_Homo sapiens_hsa034201.40489503
16Olfactory transduction_Homo sapiens_hsa047401.40392041
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35461706
18Circadian rhythm_Homo sapiens_hsa047101.30353882
19Selenocompound metabolism_Homo sapiens_hsa004501.28271273
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26716964
21Retinol metabolism_Homo sapiens_hsa008301.23848221
22GABAergic synapse_Homo sapiens_hsa047271.21517044
23Basal transcription factors_Homo sapiens_hsa030221.18832755
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18741808
25One carbon pool by folate_Homo sapiens_hsa006701.18434066
26Vitamin B6 metabolism_Homo sapiens_hsa007501.14719348
27Linoleic acid metabolism_Homo sapiens_hsa005911.14095056
28Nicotine addiction_Homo sapiens_hsa050331.11694270
29Caffeine metabolism_Homo sapiens_hsa002321.11240821
30Tryptophan metabolism_Homo sapiens_hsa003801.10516264
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07749627
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07099966
33Morphine addiction_Homo sapiens_hsa050321.01608625
34Ether lipid metabolism_Homo sapiens_hsa005651.01589928
35Base excision repair_Homo sapiens_hsa034101.00293726
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00003786
37Purine metabolism_Homo sapiens_hsa002300.99807318
38RNA transport_Homo sapiens_hsa030130.99422982
39Sphingolipid metabolism_Homo sapiens_hsa006000.98312875
40Fatty acid elongation_Homo sapiens_hsa000620.97730638
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96170919
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93486105
43Spliceosome_Homo sapiens_hsa030400.93102103
44Pyrimidine metabolism_Homo sapiens_hsa002400.91502297
45Serotonergic synapse_Homo sapiens_hsa047260.89136776
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88499737
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87787910
48Glutamatergic synapse_Homo sapiens_hsa047240.87709945
49Mineral absorption_Homo sapiens_hsa049780.83383794
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.83232959
51Peroxisome_Homo sapiens_hsa041460.81561596
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.81274161
53Arachidonic acid metabolism_Homo sapiens_hsa005900.80552169
54Circadian entrainment_Homo sapiens_hsa047130.74966791
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72949671
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72782378
57Cell cycle_Homo sapiens_hsa041100.72080511
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69967630
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68364986
60Fanconi anemia pathway_Homo sapiens_hsa034600.68204544
61Huntingtons disease_Homo sapiens_hsa050160.67371908
62Insulin secretion_Homo sapiens_hsa049110.67115449
63Cholinergic synapse_Homo sapiens_hsa047250.65241219
64Cardiac muscle contraction_Homo sapiens_hsa042600.62492212
65Glycerolipid metabolism_Homo sapiens_hsa005610.62238118
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.62116307
67Oocyte meiosis_Homo sapiens_hsa041140.61016212
68ABC transporters_Homo sapiens_hsa020100.59033234
69Folate biosynthesis_Homo sapiens_hsa007900.58431759
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57992579
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57904428
72Hippo signaling pathway_Homo sapiens_hsa043900.57846659
73Collecting duct acid secretion_Homo sapiens_hsa049660.55606038
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55518449
75Fructose and mannose metabolism_Homo sapiens_hsa000510.54968877
76beta-Alanine metabolism_Homo sapiens_hsa004100.54708148
77Fatty acid biosynthesis_Homo sapiens_hsa000610.53428799
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52286925
79Renin secretion_Homo sapiens_hsa049240.51822147
80Dopaminergic synapse_Homo sapiens_hsa047280.50883769
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49898981
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49217850
83Taste transduction_Homo sapiens_hsa047420.48947028
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47343776
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46765853
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45811929
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45679697
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45580643
89Salivary secretion_Homo sapiens_hsa049700.45548523
90Ovarian steroidogenesis_Homo sapiens_hsa049130.44960016
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44449939
92Oxidative phosphorylation_Homo sapiens_hsa001900.44423774
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44103345
94Protein export_Homo sapiens_hsa030600.43646856
95TGF-beta signaling pathway_Homo sapiens_hsa043500.42937775
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42242388
97p53 signaling pathway_Homo sapiens_hsa041150.41189429
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40208023
99Rheumatoid arthritis_Homo sapiens_hsa053230.39088519
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38807787
101cAMP signaling pathway_Homo sapiens_hsa040240.37800749
102Inositol phosphate metabolism_Homo sapiens_hsa005620.37196242
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36506094
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34025247
105Amphetamine addiction_Homo sapiens_hsa050310.33844118
106mRNA surveillance pathway_Homo sapiens_hsa030150.33814231
107Cocaine addiction_Homo sapiens_hsa050300.32908113
108Steroid biosynthesis_Homo sapiens_hsa001000.32402699
109Calcium signaling pathway_Homo sapiens_hsa040200.32028551
110Fat digestion and absorption_Homo sapiens_hsa049750.31774205
111RNA degradation_Homo sapiens_hsa030180.31483408
112Pancreatic secretion_Homo sapiens_hsa049720.30233391
113Vitamin digestion and absorption_Homo sapiens_hsa049770.29482052
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.26829856
115Hedgehog signaling pathway_Homo sapiens_hsa043400.26160696
116Chemical carcinogenesis_Homo sapiens_hsa052040.25053521
117Regulation of autophagy_Homo sapiens_hsa041400.25000304
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24923700
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24728866
120Protein digestion and absorption_Homo sapiens_hsa049740.24269899
121Oxytocin signaling pathway_Homo sapiens_hsa049210.23882363
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23645222
123Glucagon signaling pathway_Homo sapiens_hsa049220.23048154
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22819860
125Gastric acid secretion_Homo sapiens_hsa049710.22641504
126Autoimmune thyroid disease_Homo sapiens_hsa053200.22550895
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.22111483
128Glutathione metabolism_Homo sapiens_hsa004800.21932745
129Wnt signaling pathway_Homo sapiens_hsa043100.21529134
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.21369169
131Metabolic pathways_Homo sapiens_hsa011000.20731447
132Alzheimers disease_Homo sapiens_hsa050100.20156328
133Pyruvate metabolism_Homo sapiens_hsa006200.19850394
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19338605
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17806312
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17659937
137Sulfur metabolism_Homo sapiens_hsa009200.17584384
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16999292
139Ras signaling pathway_Homo sapiens_hsa040140.15903688
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15705410
141Alcoholism_Homo sapiens_hsa050340.15157139
142Axon guidance_Homo sapiens_hsa043600.13779392
143Dorso-ventral axis formation_Homo sapiens_hsa043200.12786963
144Basal cell carcinoma_Homo sapiens_hsa052170.12628592
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.12081936
146Vibrio cholerae infection_Homo sapiens_hsa051100.11544035

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