FAM153C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.29241118
2sperm motility (GO:0030317)4.80116137
3cellular ketone body metabolic process (GO:0046950)4.66922584
4behavioral response to nicotine (GO:0035095)4.55444988
5protein polyglutamylation (GO:0018095)4.39647911
6acrosome reaction (GO:0007340)4.34303703
7detection of light stimulus involved in visual perception (GO:0050908)4.32248772
8detection of light stimulus involved in sensory perception (GO:0050962)4.32248772
9ketone body metabolic process (GO:1902224)4.14801602
10multicellular organism reproduction (GO:0032504)4.14399423
11L-fucose catabolic process (GO:0042355)4.12557788
12fucose catabolic process (GO:0019317)4.12557788
13L-fucose metabolic process (GO:0042354)4.12557788
14gamma-aminobutyric acid transport (GO:0015812)4.04808194
15epithelial cilium movement (GO:0003351)3.65004512
16regulation of cilium movement (GO:0003352)3.62170186
17piRNA metabolic process (GO:0034587)3.58566809
18establishment of protein localization to Golgi (GO:0072600)3.57835283
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.54596780
20fusion of sperm to egg plasma membrane (GO:0007342)3.38035474
21protein targeting to Golgi (GO:0000042)3.36056271
22negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35745916
23calcium ion-dependent exocytosis (GO:0017156)3.34401741
24cilium or flagellum-dependent cell motility (GO:0001539)3.34223763
25detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.30798664
26axoneme assembly (GO:0035082)3.24340321
27spermatid development (GO:0007286)3.17289337
28tryptophan catabolic process (GO:0006569)3.13833657
29indole-containing compound catabolic process (GO:0042436)3.13833657
30indolalkylamine catabolic process (GO:0046218)3.13833657
31primary amino compound metabolic process (GO:1901160)3.12523209
32cilium movement (GO:0003341)3.06035519
33DNA methylation involved in gamete generation (GO:0043046)3.05778450
34negative regulation of cytosolic calcium ion concentration (GO:0051481)3.05566246
35neuronal action potential propagation (GO:0019227)3.04662707
36indolalkylamine metabolic process (GO:0006586)3.04488506
37cAMP catabolic process (GO:0006198)3.03331168
38membrane depolarization during action potential (GO:0086010)3.00797007
39reproduction (GO:0000003)3.00577813
40DNA deamination (GO:0045006)2.99715898
41organic cation transport (GO:0015695)2.99598954
42neuronal action potential (GO:0019228)2.96351598
43C4-dicarboxylate transport (GO:0015740)2.95682757
44retrograde transport, vesicle recycling within Golgi (GO:0000301)2.95678772
45water-soluble vitamin biosynthetic process (GO:0042364)2.95054253
46protein localization to Golgi apparatus (GO:0034067)2.94195511
47regulation of glucokinase activity (GO:0033131)2.92636623
48regulation of hexokinase activity (GO:1903299)2.92636623
49regulation of microtubule-based movement (GO:0060632)2.90470233
50sperm-egg recognition (GO:0035036)2.87319109
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87112731
52cyclic nucleotide catabolic process (GO:0009214)2.86856986
53alanine transport (GO:0032328)2.86150132
54axonemal dynein complex assembly (GO:0070286)2.82944770
55plasma membrane fusion (GO:0045026)2.79304495
56retinal cone cell development (GO:0046549)2.78109418
57tryptophan metabolic process (GO:0006568)2.75483184
58kynurenine metabolic process (GO:0070189)2.73559311
59indole-containing compound metabolic process (GO:0042430)2.72968375
60spinal cord motor neuron differentiation (GO:0021522)2.72940336
61behavioral response to ethanol (GO:0048149)2.71320272
62centriole replication (GO:0007099)2.69622941
63coenzyme catabolic process (GO:0009109)2.69249784
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69114603
65cilium organization (GO:0044782)2.68097329
66preassembly of GPI anchor in ER membrane (GO:0016254)2.66362865
67regulation of neurotransmitter uptake (GO:0051580)2.65664307
68serotonin metabolic process (GO:0042428)2.62761462
69phosphatidylethanolamine biosynthetic process (GO:0006646)2.61679819
70negative regulation of telomere maintenance (GO:0032205)2.61340960
71single strand break repair (GO:0000012)2.60543426
72cilium assembly (GO:0042384)2.60196604
73positive regulation of meiosis (GO:0045836)2.60174734
74reflex (GO:0060004)2.59880735
75nephron epithelium morphogenesis (GO:0072088)2.58615900
76nephron tubule morphogenesis (GO:0072078)2.58615900
77kidney morphogenesis (GO:0060993)2.58258568
78NAD biosynthetic process (GO:0009435)2.57335762
79phosphatidylethanolamine metabolic process (GO:0046337)2.57063546
80photoreceptor cell maintenance (GO:0045494)2.56909784
81auditory receptor cell stereocilium organization (GO:0060088)2.56221162
82male meiosis (GO:0007140)2.55729988
83seminiferous tubule development (GO:0072520)2.55583171
84regulation of action potential (GO:0098900)2.54049475
85RNA destabilization (GO:0050779)2.53009936
86proline transport (GO:0015824)2.52945252
87protein localization to cilium (GO:0061512)2.52842782
88positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.52257156
89inositol phosphate catabolic process (GO:0071545)2.48538027
90protein K11-linked deubiquitination (GO:0035871)2.47590333
91somite rostral/caudal axis specification (GO:0032525)2.47573793
92cell-cell recognition (GO:0009988)2.46591871
93glycerophospholipid catabolic process (GO:0046475)2.45949151
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43850347
95nonmotile primary cilium assembly (GO:0035058)2.42651392
96positive regulation of meiotic cell cycle (GO:0051446)2.42626565
97regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42086354
98regulation of mesoderm development (GO:2000380)2.40437274
99platelet dense granule organization (GO:0060155)2.40009560
100cell wall macromolecule metabolic process (GO:0044036)2.39728259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.63665614
2EZH2_22144423_ChIP-Seq_EOC_Human3.10263427
3GBX2_23144817_ChIP-Seq_PC3_Human2.93677599
4VDR_22108803_ChIP-Seq_LS180_Human2.65286606
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64896810
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43240388
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41797137
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31275947
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21953243
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20985534
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14770521
12FUS_26573619_Chip-Seq_HEK293_Human2.10323768
13TAF15_26573619_Chip-Seq_HEK293_Human2.02530360
14ER_23166858_ChIP-Seq_MCF-7_Human2.01460134
15* P300_19829295_ChIP-Seq_ESCs_Human1.98007396
16IGF1R_20145208_ChIP-Seq_DFB_Human1.97246119
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.92832573
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72954645
19REST_21632747_ChIP-Seq_MESCs_Mouse1.71966622
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70686616
21CBP_20019798_ChIP-Seq_JUKART_Human1.70686616
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64820696
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61967922
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61346157
25SMAD4_21799915_ChIP-Seq_A2780_Human1.58416431
26AR_25329375_ChIP-Seq_VCAP_Human1.58416308
27EWS_26573619_Chip-Seq_HEK293_Human1.57303074
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57176269
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55859311
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55109241
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55109241
32STAT3_23295773_ChIP-Seq_U87_Human1.53951061
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52434981
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47512235
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43994534
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43540436
37TCF4_23295773_ChIP-Seq_U87_Human1.42421123
38BCAT_22108803_ChIP-Seq_LS180_Human1.42124865
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41785119
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.41282403
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.40959098
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.40402935
43SOX2_19829295_ChIP-Seq_ESCs_Human1.37774596
44NANOG_19829295_ChIP-Seq_ESCs_Human1.37774596
45TP53_22573176_ChIP-Seq_HFKS_Human1.36194384
46AR_21572438_ChIP-Seq_LNCaP_Human1.35025804
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34952420
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34404421
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.34390059
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32726261
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.32726261
52* RUNX2_22187159_ChIP-Seq_PCA_Human1.32673188
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.32365352
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32344385
55* GATA3_21878914_ChIP-Seq_MCF-7_Human1.30101817
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.27601086
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26717524
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26425643
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26132133
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26020820
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23999130
62DROSHA_22980978_ChIP-Seq_HELA_Human1.23331701
63TCF4_22108803_ChIP-Seq_LS180_Human1.22057982
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21952618
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21142822
66RNF2_27304074_Chip-Seq_NSC_Mouse1.20100523
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19349699
68IRF1_19129219_ChIP-ChIP_H3396_Human1.19076375
69NCOR_22424771_ChIP-Seq_293T_Human1.17813045
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17705584
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16533224
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.16171489
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15482183
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15449647
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15327634
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13964885
77MYC_19829295_ChIP-Seq_ESCs_Human1.13713912
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.11862597
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.11554357
80ERA_21632823_ChIP-Seq_H3396_Human1.11541221
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.10889444
82HOXB7_26014856_ChIP-Seq_BT474_Human1.10457680
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.07761297
84NANOG_20526341_ChIP-Seq_ESCs_Human1.05179569
85AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04808248
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.04614855
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03826228
88AR_20517297_ChIP-Seq_VCAP_Human1.00704939
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00694257
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99777406
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99710432
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99453181
93TAF2_19829295_ChIP-Seq_ESCs_Human0.99286569
94P53_22387025_ChIP-Seq_ESCs_Mouse0.99074449
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98778894
96CDX2_22108803_ChIP-Seq_LS180_Human0.98391829
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97998750
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.97980972
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97720307
100EZH2_27304074_Chip-Seq_ESCs_Mouse0.96618132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.35215466
2MP0008877_abnormal_DNA_methylation2.87105315
3MP0003195_calcinosis2.80873178
4MP0001968_abnormal_touch/_nociception2.74167880
5MP0005551_abnormal_eye_electrophysiolog2.47817809
6MP0009745_abnormal_behavioral_response2.41299147
7MP0009046_muscle_twitch2.35829961
8MP0003880_abnormal_central_pattern2.22251708
9MP0005645_abnormal_hypothalamus_physiol2.19369378
10MP0001501_abnormal_sleep_pattern2.11115183
11MP0002272_abnormal_nervous_system2.08733898
12MP0002837_dystrophic_cardiac_calcinosis2.08688217
13MP0003646_muscle_fatigue2.05034108
14MP0005646_abnormal_pituitary_gland2.00870349
15MP0004885_abnormal_endolymph2.00605763
16MP0001486_abnormal_startle_reflex2.00426480
17MP0002736_abnormal_nociception_after1.95599273
18MP0002102_abnormal_ear_morphology1.93431566
19MP0000569_abnormal_digit_pigmentation1.85416358
20MP0008872_abnormal_physiological_respon1.84598352
21MP0002064_seizures1.83713274
22MP0004147_increased_porphyrin_level1.83157796
23MP0003787_abnormal_imprinting1.82771878
24MP0002735_abnormal_chemical_nociception1.76728569
25MP0006072_abnormal_retinal_apoptosis1.74483686
26MP0002876_abnormal_thyroid_physiology1.73331431
27MP0001986_abnormal_taste_sensitivity1.72750479
28MP0005253_abnormal_eye_physiology1.72125821
29MP0002572_abnormal_emotion/affect_behav1.71212938
30MP0003878_abnormal_ear_physiology1.70831637
31MP0005377_hearing/vestibular/ear_phenot1.70831637
32MP0003011_delayed_dark_adaptation1.67298893
33MP0008875_abnormal_xenobiotic_pharmacok1.67006436
34MP0001485_abnormal_pinna_reflex1.62763641
35MP0003635_abnormal_synaptic_transmissio1.61343553
36MP0003698_abnormal_male_reproductive1.61290150
37MP0002557_abnormal_social/conspecific_i1.57903206
38MP0004742_abnormal_vestibular_system1.53103326
39MP0001984_abnormal_olfaction1.45157267
40MP0005379_endocrine/exocrine_gland_phen1.44917348
41MP0005423_abnormal_somatic_nervous1.44033008
42MP0002138_abnormal_hepatobiliary_system1.43467323
43MP0004142_abnormal_muscle_tone1.42705927
44MP0001970_abnormal_pain_threshold1.42135447
45MP0002067_abnormal_sensory_capabilities1.39605748
46MP0002733_abnormal_thermal_nociception1.38511036
47MP0002063_abnormal_learning/memory/cond1.37222675
48MP0006276_abnormal_autonomic_nervous1.35468250
49MP0001929_abnormal_gametogenesis1.34451684
50MP0004859_abnormal_synaptic_plasticity1.32151356
51MP0004043_abnormal_pH_regulation1.31145491
52MP0005084_abnormal_gallbladder_morpholo1.29958312
53MP0002638_abnormal_pupillary_reflex1.29444260
54MP0002734_abnormal_mechanical_nocicepti1.28770983
55MP0001529_abnormal_vocalization1.27318126
56MP0001905_abnormal_dopamine_level1.27297660
57MP0006292_abnormal_olfactory_placode1.26982016
58MP0010386_abnormal_urinary_bladder1.26527021
59MP0004924_abnormal_behavior1.22744584
60MP0005386_behavior/neurological_phenoty1.22744584
61MP0003283_abnormal_digestive_organ1.22153176
62MP0003136_yellow_coat_color1.19823008
63MP0000427_abnormal_hair_cycle1.19454383
64MP0000631_abnormal_neuroendocrine_gland1.18430892
65MP0005167_abnormal_blood-brain_barrier1.16030223
66MP0002234_abnormal_pharynx_morphology1.15961599
67MP0002229_neurodegeneration1.14297023
68MP0002653_abnormal_ependyma_morphology1.05974951
69MP0001963_abnormal_hearing_physiology1.05197240
70MP0002909_abnormal_adrenal_gland1.04467682
71MP0005174_abnormal_tail_pigmentation1.03960527
72MP0005389_reproductive_system_phenotype1.03185756
73MP0003718_maternal_effect1.00723653
74MP0000372_irregular_coat_pigmentation1.00074592
75MP0002693_abnormal_pancreas_physiology0.98422006
76MP0002160_abnormal_reproductive_system0.98381338
77MP0002928_abnormal_bile_duct0.96036763
78MP0002938_white_spotting0.94047395
79MP0004270_analgesia0.93667391
80MP0005332_abnormal_amino_acid0.92866919
81MP0004133_heterotaxia0.91799508
82MP0010329_abnormal_lipoprotein_level0.91590417
83MP0001765_abnormal_ion_homeostasis0.89686322
84MP0009780_abnormal_chondrocyte_physiolo0.88954858
85MP0002822_catalepsy0.88759324
86MP0008995_early_reproductive_senescence0.86533697
87MP0003137_abnormal_impulse_conducting0.86396311
88MP0001440_abnormal_grooming_behavior0.85949443
89MP0000230_abnormal_systemic_arterial0.85648787
90MP0000026_abnormal_inner_ear0.85627885
91MP0004085_abnormal_heartbeat0.83776816
92MP0002184_abnormal_innervation0.83594199
93MP0005195_abnormal_posterior_eye0.82732520
94MP0001944_abnormal_pancreas_morphology0.81450651
95MP0001502_abnormal_circadian_rhythm0.81274541
96MP0002210_abnormal_sex_determination0.81063420
97MP0003633_abnormal_nervous_system0.79686619
98MP0004145_abnormal_muscle_electrophysio0.79095131
99MP0004215_abnormal_myocardial_fiber0.79014433
100MP0008775_abnormal_heart_ventricle0.78765655

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.46564383
2Abnormal rod and cone electroretinograms (HP:0008323)4.04219730
3Attenuation of retinal blood vessels (HP:0007843)3.94977165
4Pancreatic cysts (HP:0001737)3.89730817
5Molar tooth sign on MRI (HP:0002419)3.69403377
6Abnormality of midbrain morphology (HP:0002418)3.69403377
7Pancreatic fibrosis (HP:0100732)3.65531401
8Nephronophthisis (HP:0000090)3.62903643
9Type II lissencephaly (HP:0007260)3.56834019
10Abnormality of the renal cortex (HP:0011035)3.34524906
11True hermaphroditism (HP:0010459)3.34242678
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.26633353
13Absent/shortened dynein arms (HP:0200106)3.26633353
14Abnormal drinking behavior (HP:0030082)3.17960112
15Polydipsia (HP:0001959)3.17960112
16Abnormality of the renal medulla (HP:0100957)3.16825239
17Abnormality of macular pigmentation (HP:0008002)3.16208550
18Chronic hepatic failure (HP:0100626)3.16177862
19Severe visual impairment (HP:0001141)3.13784909
20Hyperventilation (HP:0002883)2.98423913
21Progressive cerebellar ataxia (HP:0002073)2.87308092
22Tubular atrophy (HP:0000092)2.85914423
23Inability to walk (HP:0002540)2.81495764
24Bony spicule pigmentary retinopathy (HP:0007737)2.77226586
25Decreased central vision (HP:0007663)2.77179377
26Gaze-evoked nystagmus (HP:0000640)2.74800450
27Abolished electroretinogram (ERG) (HP:0000550)2.67905996
28Medial flaring of the eyebrow (HP:0010747)2.67757568
29Aplasia/Hypoplasia of the fovea (HP:0008060)2.64312544
30Hypoplasia of the fovea (HP:0007750)2.64312544
31Febrile seizures (HP:0002373)2.64207389
32Pendular nystagmus (HP:0012043)2.58507718
33Polyuria (HP:0000103)2.56283650
34Abnormal respiratory epithelium morphology (HP:0012253)2.53206701
35Abnormal respiratory motile cilium morphology (HP:0005938)2.53206701
36Cystic liver disease (HP:0006706)2.48792885
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46011551
38Hemiparesis (HP:0001269)2.44146114
39Cerebellar dysplasia (HP:0007033)2.43615380
40Renal cortical cysts (HP:0000803)2.38675075
41Hypothermia (HP:0002045)2.38030930
42Increased corneal curvature (HP:0100692)2.36212202
43Keratoconus (HP:0000563)2.36212202
44Lissencephaly (HP:0001339)2.35307168
45Large for gestational age (HP:0001520)2.34563112
46Retinal dysplasia (HP:0007973)2.30080107
47Abnormal ciliary motility (HP:0012262)2.29381295
48Abnormal urine output (HP:0012590)2.23807802
49Abnormality of the fovea (HP:0000493)2.19751737
50Hyperalaninemia (HP:0003348)2.19646613
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19646613
52Abnormality of alanine metabolism (HP:0010916)2.19646613
53Focal motor seizures (HP:0011153)2.19059486
54Progressive inability to walk (HP:0002505)2.16043425
55Optic nerve hypoplasia (HP:0000609)2.15072386
56Broad-based gait (HP:0002136)2.14594187
57Genetic anticipation (HP:0003743)2.11938716
58Decreased circulating renin level (HP:0003351)2.07305274
59Gait imbalance (HP:0002141)2.02592281
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01576489
61Abnormality of renal excretion (HP:0011036)2.00132453
62Sclerocornea (HP:0000647)1.98684617
63Epileptic encephalopathy (HP:0200134)1.98107748
64Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98021650
65Abnormal biliary tract physiology (HP:0012439)1.95194351
66Bile duct proliferation (HP:0001408)1.95194351
67Ketosis (HP:0001946)1.93965393
68Abnormal respiratory motile cilium physiology (HP:0012261)1.93651204
69Aplasia/Hypoplasia of the tibia (HP:0005772)1.92169948
70Severe muscular hypotonia (HP:0006829)1.91965439
71Chorioretinal atrophy (HP:0000533)1.91738231
72Congenital hepatic fibrosis (HP:0002612)1.91545270
73Focal seizures (HP:0007359)1.90802013
74Congenital primary aphakia (HP:0007707)1.89927651
75Absent speech (HP:0001344)1.89868296
76Intestinal atresia (HP:0011100)1.89753242
77Hypomagnesemia (HP:0002917)1.88772099
78Atonic seizures (HP:0010819)1.88170062
79Protruding tongue (HP:0010808)1.86391820
80Furrowed tongue (HP:0000221)1.85916690
81Nephrogenic diabetes insipidus (HP:0009806)1.85424056
82Ketoacidosis (HP:0001993)1.84190749
83Anencephaly (HP:0002323)1.80718119
84Optic disc pallor (HP:0000543)1.80577422
85Amelogenesis imperfecta (HP:0000705)1.80359771
86Congenital sensorineural hearing impairment (HP:0008527)1.79939335
87Tubulointerstitial nephritis (HP:0001970)1.79717428
88Abnormality of urine glucose concentration (HP:0011016)1.79672099
89Glycosuria (HP:0003076)1.79672099
90Male pseudohermaphroditism (HP:0000037)1.78676581
91Tubulointerstitial abnormality (HP:0001969)1.76449372
92Pachygyria (HP:0001302)1.75715733
93Albinism (HP:0001022)1.75411644
94Genital tract atresia (HP:0001827)1.73110606
95Stomach cancer (HP:0012126)1.73060037
96Widely spaced teeth (HP:0000687)1.70546826
97Dialeptic seizures (HP:0011146)1.68685230
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.68130873
99Congenital, generalized hypertrichosis (HP:0004540)1.65619569
100Generalized aminoaciduria (HP:0002909)1.63614164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.99240144
2MAP4K23.59998294
3BMPR1B3.12748017
4ADRBK23.06205051
5INSRR2.70939197
6GRK12.48187138
7PINK12.35889972
8ACVR1B2.35868255
9ZAK2.25707674
10DAPK22.23279393
11TAOK32.15657474
12WNK32.08151189
13WNK42.03526300
14CASK1.97071937
15MAPK131.86072575
16PLK41.79167489
17NUAK11.78304407
18TLK11.74393716
19PLK21.72790956
20OXSR11.61324178
21NTRK31.52008894
22STK391.51809974
23MAP3K41.37119681
24PHKG11.23593003
25PHKG21.23593003
26PTK2B1.22702922
27PAK31.21754752
28CAMKK21.21005244
29MARK11.18893314
30PNCK1.18866217
31MKNK21.16764299
32STK38L1.13583477
33TXK1.05640576
34MAPKAPK31.03662256
35ADRBK11.03405853
36PRKCG1.02983870
37PRKCE1.02250350
38FGFR21.01637933
39TGFBR10.98551634
40MAP2K70.92460482
41MAP2K60.88582062
42MAPK150.83262379
43CAMK10.74793586
44DYRK20.74546591
45MUSK0.73862424
46EPHA40.71296423
47CSNK1G20.68247300
48STK380.67845752
49CSNK1G10.66942342
50CAMK2A0.66450304
51CSNK1G30.65703825
52VRK10.59739470
53PRKD30.58889504
54TNK20.58714487
55STK110.58191783
56BCKDK0.58152002
57TNIK0.57978861
58PRKCQ0.57693203
59IRAK10.56593755
60IKBKB0.56020754
61CAMK1G0.55567687
62PKN10.55216973
63MAPKAPK50.54342932
64KIT0.53648363
65RPS6KA50.53332530
66NTRK20.52992922
67TRPM70.51888806
68CAMKK10.51524704
69CSNK1A1L0.51071275
70TEC0.50439280
71MKNK10.49970219
72ERBB30.49795935
73PAK60.49111995
74GRK50.48779643
75PRKACA0.48432332
76EIF2AK30.46925795
77PRKG10.46869437
78WNK10.46441351
79TIE10.46069186
80TRIM280.45306305
81FER0.44750766
82PRKAA20.44603878
83PIK3CA0.42213462
84CSNK1A10.39056489
85MST40.37757362
86ITK0.37272534
87PRKCZ0.37061271
88PRKCA0.36464060
89CAMK40.35625644
90CSNK1D0.35569913
91PLK30.35315982
92CDK30.34550864
93BRSK20.34308654
94BRD40.34048670
95PRKAA10.33506129
96CHUK0.32777029
97CAMK1D0.31993459
98SIK20.30873384
99STK30.30631132
100NLK0.30361213

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.18898410
2Butanoate metabolism_Homo sapiens_hsa006502.85697276
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.77652027
4Nitrogen metabolism_Homo sapiens_hsa009102.72043187
5Phototransduction_Homo sapiens_hsa047442.66224157
6Nicotine addiction_Homo sapiens_hsa050332.56011420
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.43287344
8Linoleic acid metabolism_Homo sapiens_hsa005912.31310064
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15950920
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05963751
11Olfactory transduction_Homo sapiens_hsa047402.02546478
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01837199
13Insulin secretion_Homo sapiens_hsa049111.82074823
14Selenocompound metabolism_Homo sapiens_hsa004501.79541316
15Morphine addiction_Homo sapiens_hsa050321.77199398
16Taste transduction_Homo sapiens_hsa047421.74386256
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73387918
18Ether lipid metabolism_Homo sapiens_hsa005651.64959235
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64292727
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61177409
21GABAergic synapse_Homo sapiens_hsa047271.60346443
22Circadian entrainment_Homo sapiens_hsa047131.60092809
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58959480
24Tryptophan metabolism_Homo sapiens_hsa003801.50293256
25Oxidative phosphorylation_Homo sapiens_hsa001901.45204781
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40957507
27Glutamatergic synapse_Homo sapiens_hsa047241.34179900
28Salivary secretion_Homo sapiens_hsa049701.29457528
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.29261510
30Fatty acid biosynthesis_Homo sapiens_hsa000611.28716115
31Serotonergic synapse_Homo sapiens_hsa047261.28278804
32Protein export_Homo sapiens_hsa030601.27651330
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23486959
34ABC transporters_Homo sapiens_hsa020101.22464647
35Caffeine metabolism_Homo sapiens_hsa002321.22046322
36Cardiac muscle contraction_Homo sapiens_hsa042601.20735012
37Propanoate metabolism_Homo sapiens_hsa006401.16952753
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16874999
39Basal transcription factors_Homo sapiens_hsa030221.12544228
40Peroxisome_Homo sapiens_hsa041461.11861153
41Type I diabetes mellitus_Homo sapiens_hsa049401.08377107
42Calcium signaling pathway_Homo sapiens_hsa040201.06874857
43Arachidonic acid metabolism_Homo sapiens_hsa005900.97411523
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.96338666
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94183211
46Amphetamine addiction_Homo sapiens_hsa050310.91559147
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91388839
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91370301
49Chemical carcinogenesis_Homo sapiens_hsa052040.90284993
50Parkinsons disease_Homo sapiens_hsa050120.89414564
51Dorso-ventral axis formation_Homo sapiens_hsa043200.88571951
52Synaptic vesicle cycle_Homo sapiens_hsa047210.88533273
53Homologous recombination_Homo sapiens_hsa034400.87848891
54beta-Alanine metabolism_Homo sapiens_hsa004100.87392354
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.87150581
56Renin secretion_Homo sapiens_hsa049240.87110488
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86722574
58Collecting duct acid secretion_Homo sapiens_hsa049660.85813089
59Regulation of autophagy_Homo sapiens_hsa041400.83948945
60Dopaminergic synapse_Homo sapiens_hsa047280.82112332
61Ovarian steroidogenesis_Homo sapiens_hsa049130.81140166
62Retinol metabolism_Homo sapiens_hsa008300.79685493
63RNA polymerase_Homo sapiens_hsa030200.75906427
64Gastric acid secretion_Homo sapiens_hsa049710.74898292
65Fanconi anemia pathway_Homo sapiens_hsa034600.74547379
66Long-term depression_Homo sapiens_hsa047300.73582556
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73066721
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.72283393
69Mineral absorption_Homo sapiens_hsa049780.71530333
70RNA degradation_Homo sapiens_hsa030180.70693196
71Oxytocin signaling pathway_Homo sapiens_hsa049210.70636198
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.70223993
73cAMP signaling pathway_Homo sapiens_hsa040240.67993572
74Alzheimers disease_Homo sapiens_hsa050100.66450194
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66191940
76Circadian rhythm_Homo sapiens_hsa047100.65555332
77Histidine metabolism_Homo sapiens_hsa003400.64863416
78Fatty acid degradation_Homo sapiens_hsa000710.64556935
79Glycerolipid metabolism_Homo sapiens_hsa005610.63696163
80Asthma_Homo sapiens_hsa053100.61154854
81Huntingtons disease_Homo sapiens_hsa050160.60911778
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60485836
83Cholinergic synapse_Homo sapiens_hsa047250.59618054
84Purine metabolism_Homo sapiens_hsa002300.59400978
85Fat digestion and absorption_Homo sapiens_hsa049750.55203517
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54823864
87Cocaine addiction_Homo sapiens_hsa050300.54302576
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51749813
89Metabolic pathways_Homo sapiens_hsa011000.49647130
90Fatty acid metabolism_Homo sapiens_hsa012120.48170470
91Allograft rejection_Homo sapiens_hsa053300.46869728
92Type II diabetes mellitus_Homo sapiens_hsa049300.46555680
93Autoimmune thyroid disease_Homo sapiens_hsa053200.45333805
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44624715
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43480217
96Graft-versus-host disease_Homo sapiens_hsa053320.41851442
97Arginine and proline metabolism_Homo sapiens_hsa003300.41139402
98Pancreatic secretion_Homo sapiens_hsa049720.40044107
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38892254
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38518583

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