FAM149B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrocyte maturation (GO:0043249)9.53712969
2granulocyte differentiation (GO:0030851)8.86115199
3positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)7.36752713
4histone H2B ubiquitination (GO:0033523)7.25522287
5response to nitrosative stress (GO:0051409)7.12848593
6response to misfolded protein (GO:0051788)7.12519197
7macrophage differentiation (GO:0030225)6.35942542
8estrogen biosynthetic process (GO:0006703)6.30285117
9cell fate commitment involved in formation of primary germ layer (GO:0060795)6.09504485
10protein destabilization (GO:0031648)5.96810259
11ribonucleoprotein complex disassembly (GO:0032988)5.91481845
12negative regulation of calcium ion-dependent exocytosis (GO:0045955)5.90580593
13xenobiotic catabolic process (GO:0042178)5.89714605
14misfolded or incompletely synthesized protein catabolic process (GO:0006515)5.56632078
15negative regulation of NF-kappaB import into nucleus (GO:0042347)5.36609298
16regulation of autophagic vacuole assembly (GO:2000785)5.01052145
17negative regulation of leukocyte migration (GO:0002686)4.94822821
18positive regulation of mRNA 3-end processing (GO:0031442)4.89716096
19cerebellar granule cell differentiation (GO:0021707)4.76063502
20monoubiquitinated protein deubiquitination (GO:0035520)4.67136345
21CDP-diacylglycerol biosynthetic process (GO:0016024)4.63393723
22cardiolipin metabolic process (GO:0032048)4.62448999
23phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.56551685
24cytoplasmic sequestering of transcription factor (GO:0042994)4.50529537
25regulation of mRNA 3-end processing (GO:0031440)4.47789725
26histone H2A acetylation (GO:0043968)4.45249600
27organelle disassembly (GO:1903008)4.38858385
28kinetochore organization (GO:0051383)4.29355891
29serotonin metabolic process (GO:0042428)4.08705561
30early endosome to late endosome transport (GO:0045022)4.06968923
31positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)4.04704716
32CDP-diacylglycerol metabolic process (GO:0046341)4.01459128
33regulation of vacuole organization (GO:0044088)3.94102600
34protein polyglutamylation (GO:0018095)3.93282610
35phosphatidylglycerol biosynthetic process (GO:0006655)3.86147445
36negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.84332414
37regulation of glucokinase activity (GO:0033131)3.79492211
38regulation of hexokinase activity (GO:1903299)3.79492211
39negative regulation of mast cell activation (GO:0033004)3.77678860
40positive regulation of mRNA processing (GO:0050685)3.73951543
41negative regulation of chemotaxis (GO:0050922)3.73010863
42mitotic G1 DNA damage checkpoint (GO:0031571)3.69084513
43negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.65610496
44cytoplasmic sequestering of protein (GO:0051220)3.62532026
45N-terminal protein amino acid acetylation (GO:0006474)3.61132337
46CENP-A containing nucleosome assembly (GO:0034080)3.59899274
47kinetochore assembly (GO:0051382)3.59677381
48G1 DNA damage checkpoint (GO:0044783)3.51444979
49DNA strand renaturation (GO:0000733)3.51132364
50chromatin remodeling at centromere (GO:0031055)3.47179720
51regulation of non-canonical Wnt signaling pathway (GO:2000050)3.38440434
52estrogen metabolic process (GO:0008210)3.37446670
53negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.35518951
54replicative senescence (GO:0090399)3.32555663
55regulation of helicase activity (GO:0051095)3.26719553
56histone exchange (GO:0043486)3.26460272
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.20815074
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.20815074
59positive regulation of mitotic sister chromatid separation (GO:1901970)3.20815074
60primary amino compound metabolic process (GO:1901160)3.19763432
61prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.19547031
62positive regulation of mRNA metabolic process (GO:1903313)3.12212606
63negative regulation of cell cycle G2/M phase transition (GO:1902750)3.09586950
64negative regulation of fibroblast proliferation (GO:0048147)3.08639468
65regulation of DNA endoreduplication (GO:0032875)3.05570817
66positive regulation of response to oxidative stress (GO:1902884)3.04055448
67positive regulation of cellular response to oxidative stress (GO:1900409)3.04055448
68mRNA polyadenylation (GO:0006378)2.98160629
69positive regulation of chromosome segregation (GO:0051984)2.97510235
70mitotic G1/S transition checkpoint (GO:0044819)2.97452104
71regulation of centriole replication (GO:0046599)2.96303309
72negative regulation of exocytosis (GO:0045920)2.95946528
73protein localization to kinetochore (GO:0034501)2.95898613
74cerebral cortex radially oriented cell migration (GO:0021799)2.90765516
75cellular protein catabolic process (GO:0044257)2.89945124
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89140022
77regulation of mitotic spindle checkpoint (GO:1903504)2.89140022
78regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.88988671
79autophagic vacuole assembly (GO:0000045)2.86326510
80negative regulation of autophagy (GO:0010507)2.85466865
81mitotic metaphase plate congression (GO:0007080)2.84800565
82mitotic chromosome condensation (GO:0007076)2.83454251
83mitotic sister chromatid segregation (GO:0000070)2.83065906
84histone monoubiquitination (GO:0010390)2.77656340
85regulation of macroautophagy (GO:0016241)2.74883979
86sister chromatid segregation (GO:0000819)2.74594121
87regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.72321026
88RNA polyadenylation (GO:0043631)2.70696992
89sodium-independent organic anion transport (GO:0043252)2.70609627
90radial glial cell differentiation (GO:0060019)2.70581348
91DNA replication checkpoint (GO:0000076)2.69563484
92negative regulation of protein localization to plasma membrane (GO:1903077)2.69185161
93sulfation (GO:0051923)2.69176601
94benzene-containing compound metabolic process (GO:0042537)2.68735767
95mitotic sister chromatid cohesion (GO:0007064)2.68594269
96G2 DNA damage checkpoint (GO:0031572)2.67087926
97meiotic chromosome segregation (GO:0045132)2.65077547
98cellular protein complex localization (GO:0034629)2.64056783
99negative regulation of leukocyte chemotaxis (GO:0002689)13.8730452
100regulation of macrophage chemotaxis (GO:0010758)10.5820929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.58024139
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.45855581
3SRY_22984422_ChIP-ChIP_TESTIS_Rat4.16597089
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.06851896
5IRF1_19129219_ChIP-ChIP_H3396_Human2.85732141
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.81398824
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.57213625
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49620704
9AR_21909140_ChIP-Seq_LNCAP_Human2.44861830
10IGF1R_20145208_ChIP-Seq_DFB_Human2.39171871
11FUS_26573619_Chip-Seq_HEK293_Human2.22677716
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.15274917
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.10245301
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.04011368
15TP53_16413492_ChIP-PET_HCT116_Human2.02090143
16E2F7_22180533_ChIP-Seq_HELA_Human11.0969196
17ESR1_15608294_ChIP-ChIP_MCF-7_Human1.93563367
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90655307
19* GBX2_23144817_ChIP-Seq_PC3_Human1.85384406
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75984277
21SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.67278385
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.63881159
23AR_25329375_ChIP-Seq_VCAP_Human1.59260150
24EWS_26573619_Chip-Seq_HEK293_Human1.54270379
25MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.52506091
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47858433
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43111491
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37097175
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.36586937
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35556093
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33808765
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33808765
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28523536
34JUN_21703547_ChIP-Seq_K562_Human1.25629030
35SMAD4_21799915_ChIP-Seq_A2780_Human1.25544816
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24493564
37TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23426633
38ELK1_19687146_ChIP-ChIP_HELA_Human1.23292437
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.23011049
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22911146
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21689844
42LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20736189
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19911819
44* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19502714
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19197699
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.18564297
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17732978
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13385546
49ER_23166858_ChIP-Seq_MCF-7_Human1.12804559
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09377012
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07861982
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07602787
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07261977
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07200519
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.07089677
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06111662
57SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05546518
58HOXB7_26014856_ChIP-Seq_BT474_Human1.05461491
59* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04791897
60TP53_22573176_ChIP-Seq_HFKS_Human1.03593845
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.02226279
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.01569219
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01033957
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98564400
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98559718
66OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98131303
67SOX2_19829295_ChIP-Seq_ESCs_Human0.97702314
68NANOG_19829295_ChIP-Seq_ESCs_Human0.97702314
69STAT3_18555785_ChIP-Seq_MESCs_Mouse0.95804977
70P300_19829295_ChIP-Seq_ESCs_Human0.95531876
71VDR_23849224_ChIP-Seq_CD4+_Human0.94885477
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94872701
73* SMAD4_21741376_ChIP-Seq_EPCs_Human0.94554013
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94009274
75TCF4_23295773_ChIP-Seq_U87_Human0.93447711
76FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93282122
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93275900
78FLI1_21867929_ChIP-Seq_TH2_Mouse0.91153984
79MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90946551
80NFYB_21822215_ChIP-Seq_K562_Human0.90724361
81PHF8_20622853_ChIP-Seq_HELA_Human0.89618173
82* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89342624
83SMAD3_21741376_ChIP-Seq_EPCs_Human0.89225391
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89161789
85MYC_18940864_ChIP-ChIP_HL60_Human0.88757448
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88123826
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88098257
88EZH2_27304074_Chip-Seq_ESCs_Mouse0.87531981
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86352311
90P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85973138
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85287034
92MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84191771
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83705661
94TBL1_22424771_ChIP-Seq_293T_Human0.82900908
95STAT3_23295773_ChIP-Seq_U87_Human0.82559852
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82201185
97CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81905107
98HTT_18923047_ChIP-ChIP_STHdh_Human0.80431312
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80351350
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80200134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000383_abnormal_hair_follicle5.66133869
2MP0004742_abnormal_vestibular_system4.79027399
3MP0006292_abnormal_olfactory_placode4.28312900
4MP0010678_abnormal_skin_adnexa4.12611369
5MP0000427_abnormal_hair_cycle3.35781777
6MP0005379_endocrine/exocrine_gland_phen3.22358646
7MP0009053_abnormal_anal_canal2.76049833
8MP0001727_abnormal_embryo_implantation2.61819707
9MP0009697_abnormal_copulation2.61137101
10MP0000647_abnormal_sebaceous_gland2.56386815
11MP0000462_abnormal_digestive_system2.34636690
12MP0002098_abnormal_vibrissa_morphology2.32296852
13MP0004957_abnormal_blastocyst_morpholog2.31410269
14MP0010368_abnormal_lymphatic_system2.26488614
15MP0003122_maternal_imprinting2.19800428
16MP0000566_synostosis2.17104765
17MP0002396_abnormal_hematopoietic_system1.95520839
18MP0004808_abnormal_hematopoietic_stem1.90790012
19MP0008057_abnormal_DNA_replication1.90376205
20MP0008932_abnormal_embryonic_tissue1.86806392
21MP0003011_delayed_dark_adaptation1.82439783
22MP0003879_abnormal_hair_cell1.79824949
23MP0003693_abnormal_embryo_hatching1.78119108
24MP0008875_abnormal_xenobiotic_pharmacok1.74944220
25MP0010094_abnormal_chromosome_stability1.74931498
26MP0003878_abnormal_ear_physiology1.73650998
27MP0005377_hearing/vestibular/ear_phenot1.73650998
28MP0003705_abnormal_hypodermis_morpholog1.71600645
29MP0004510_myositis1.66437876
30MP0000428_abnormal_craniofacial_morphol1.66285535
31MP0003121_genomic_imprinting1.57855725
32MP0003111_abnormal_nucleus_morphology1.54969287
33MP0009278_abnormal_bone_marrow1.49903540
34MP0008789_abnormal_olfactory_epithelium1.48359752
35MP0004885_abnormal_endolymph1.48207052
36MP0001485_abnormal_pinna_reflex1.41755473
37MP0010030_abnormal_orbit_morphology1.40851616
38MP0002282_abnormal_trachea_morphology1.37703285
39MP0000613_abnormal_salivary_gland1.32183172
40MP0001188_hyperpigmentation1.26155282
41MP0003077_abnormal_cell_cycle1.22852634
42MP0003941_abnormal_skin_development1.22282821
43MP0002102_abnormal_ear_morphology1.19814296
44MP0000579_abnormal_nail_morphology1.19373840
45MP0005499_abnormal_olfactory_system1.19286535
46MP0005394_taste/olfaction_phenotype1.19286535
47MP0002938_white_spotting1.18399838
48MP0005551_abnormal_eye_electrophysiolog1.15836023
49MP0000537_abnormal_urethra_morphology1.12027978
50MP0003315_abnormal_perineum_morphology1.10157171
51MP0001851_eye_inflammation1.08511398
52MP0001286_abnormal_eye_development1.07406025
53MP0004197_abnormal_fetal_growth/weight/1.07089128
54MP0005501_abnormal_skin_physiology1.06956581
55MP0008872_abnormal_physiological_respon1.06036439
56MP0000750_abnormal_muscle_regeneration1.04909913
57MP0001216_abnormal_epidermal_layer1.03831730
58MP0001270_distended_abdomen1.02917648
59MP0000377_abnormal_hair_follicle1.01878080
60MP0000350_abnormal_cell_proliferation1.01309921
61MP0006054_spinal_hemorrhage1.00372134
62MP0008058_abnormal_DNA_repair0.98799431
63MP0010771_integument_phenotype0.95020366
64MP0003937_abnormal_limbs/digits/tail_de0.94372239
65MP0005187_abnormal_penis_morphology0.93405715
66MP0005310_abnormal_salivary_gland0.90790144
67MP0002970_abnormal_white_adipose0.89807196
68MP0001915_intracranial_hemorrhage0.89544307
69MP0002233_abnormal_nose_morphology0.89261900
70MP0005076_abnormal_cell_differentiation0.88784063
71MP0002210_abnormal_sex_determination0.86924799
72MP0001293_anophthalmia0.86386202
73MP0000026_abnormal_inner_ear0.85343508
74MP0002796_impaired_skin_barrier0.84165596
75MP0001879_abnormal_lymphatic_vessel0.83279944
76MP0008007_abnormal_cellular_replicative0.82271691
77MP0003656_abnormal_erythrocyte_physiolo0.81379291
78MP0002697_abnormal_eye_size0.77497503
79MP0004147_increased_porphyrin_level0.75595624
80MP0005248_abnormal_Harderian_gland0.74698787
81MP0005367_renal/urinary_system_phenotyp0.74351074
82MP0000516_abnormal_urinary_system0.74351074
83MP0009672_abnormal_birth_weight0.72087625
84MP0002234_abnormal_pharynx_morphology0.70500021
85MP0009250_abnormal_appendicular_skeleto0.69916555
86MP0002092_abnormal_eye_morphology0.68945620
87MP0003453_abnormal_keratinocyte_physiol0.66499929
88MP0009931_abnormal_skin_appearance0.65169302
89MP0003755_abnormal_palate_morphology0.65156026
90MP0001243_abnormal_dermal_layer0.62690673
91MP0003943_abnormal_hepatobiliary_system0.62605318
92MP0001958_emphysema0.61927672
93MP0003718_maternal_effect0.61593051
94MP0002114_abnormal_axial_skeleton0.61468357
95MP0001299_abnormal_eye_distance/0.61220240
96MP0006138_congestive_heart_failure0.60755081
97MP0001764_abnormal_homeostasis0.60711912
98MP0001853_heart_inflammation0.58912130
99MP0005174_abnormal_tail_pigmentation0.56513176
100MP0005391_vision/eye_phenotype0.56361692

Predicted human phenotypes

RankGene SetZ-score
1Autoamputation (HP:0001218)9.29399153
2Osteolytic defects of the hand bones (HP:0009699)8.78473153
3Osteolytic defects of the phalanges of the hand (HP:0009771)8.78473153
4Amblyopia (HP:0000646)7.65786236
5Abnormality of the parathyroid morphology (HP:0011766)6.98370765
6Poor speech (HP:0002465)6.18310192
7Nephroblastoma (Wilms tumor) (HP:0002667)5.71262454
8Embryonal renal neoplasm (HP:0011794)5.43096902
9Increased hepatocellular lipid droplets (HP:0006565)5.36870437
10Cerebellar dysplasia (HP:0007033)4.89013761
11Lipid accumulation in hepatocytes (HP:0006561)4.74531634
12Renal Fanconi syndrome (HP:0001994)4.56041365
13Hyperparathyroidism (HP:0000843)3.80484976
14Wormian bones (HP:0002645)3.56451050
15Hyperventilation (HP:0002883)3.51485877
16Embryonal neoplasm (HP:0002898)3.49558540
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.45850954
18Exertional dyspnea (HP:0002875)3.35791663
19Colon cancer (HP:0003003)3.18184397
20Ectopic kidney (HP:0000086)3.10243446
21Increased intramyocellular lipid droplets (HP:0012240)3.04006966
22Hamartoma (HP:0010566)2.95620647
23Esotropia (HP:0000565)2.92702138
24Neoplasm of the adrenal cortex (HP:0100641)2.91278198
25Abnormality of renal resorption (HP:0011038)2.85618550
26Abnormal cortical bone morphology (HP:0003103)2.79638667
27Abnormal lung lobation (HP:0002101)2.78917277
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.76857197
29Short 4th metacarpal (HP:0010044)2.76857197
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.75162999
31Respiratory difficulties (HP:0002880)2.72786035
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.71907737
33Chromsome breakage (HP:0040012)2.64434204
34Difficulty running (HP:0009046)2.64152809
35Tapered finger (HP:0001182)2.59916615
36Facial hemangioma (HP:0000329)2.58186272
37Prostate neoplasm (HP:0100787)2.56764651
38Abnormality of the aortic arch (HP:0012303)2.53932246
39Neoplasm of the thyroid gland (HP:0100031)2.45374546
40Increased muscle lipid content (HP:0009058)2.39520780
41Osteomyelitis (HP:0002754)2.39263386
42Renal cell carcinoma (HP:0005584)2.37115292
43Intellectual disability, severe (HP:0010864)2.19817049
44Abnormality of the 4th metacarpal (HP:0010012)2.19521667
45Papillary thyroid carcinoma (HP:0002895)2.18583918
46Neoplasm of the pancreas (HP:0002894)2.15011239
47Cerebral edema (HP:0002181)2.12401947
48Abnormality of chromosome stability (HP:0003220)2.08206732
493-Methylglutaconic aciduria (HP:0003535)2.07953984
50Microglossia (HP:0000171)2.07786858
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.07571574
52Hypoplasia of the fovea (HP:0007750)2.07571574
53Genetic anticipation (HP:0003743)2.07481236
54Duodenal stenosis (HP:0100867)2.03960186
55Small intestinal stenosis (HP:0012848)2.03960186
56Acute myeloid leukemia (HP:0004808)2.00097659
57Mitochondrial inheritance (HP:0001427)1.95206306
58Oligodactyly (HP:0012165)1.92928640
59Congenital primary aphakia (HP:0007707)1.88360320
60Hypercalcemia (HP:0003072)1.87965810
61Hyperphosphaturia (HP:0003109)1.87904524
62Partial agenesis of the corpus callosum (HP:0001338)1.87144046
63Abnormal hair whorl (HP:0010721)1.85492593
64Myelodysplasia (HP:0002863)1.83105056
65Gait imbalance (HP:0002141)1.82409362
66Abnormality of the duodenum (HP:0002246)1.81432846
67Hyperglycinuria (HP:0003108)1.78418733
68Small hand (HP:0200055)1.75566546
69Aplasia/Hypoplasia of the uvula (HP:0010293)1.74950124
70Abnormality of the phalanges of the hallux (HP:0010057)1.73588315
71Abnormality of urine glucose concentration (HP:0011016)1.72288603
72Glycosuria (HP:0003076)1.72288603
73Birth length less than 3rd percentile (HP:0003561)1.70263161
74Acute necrotizing encephalopathy (HP:0006965)1.67665002
75Abnormality of the fovea (HP:0000493)1.67661718
76Thyroid carcinoma (HP:0002890)1.67421249
77Meckel diverticulum (HP:0002245)1.65202256
78Sloping forehead (HP:0000340)1.62159413
79Urinary incontinence (HP:0000020)1.61792226
80Abnormality of the preputium (HP:0100587)1.61722500
81Nephrogenic diabetes insipidus (HP:0009806)1.60978131
82Acute lymphatic leukemia (HP:0006721)1.59935047
83Tetraparesis (HP:0002273)1.59372217
84Heterotopia (HP:0002282)1.59336030
85Abnormality of cochlea (HP:0000375)1.58677665
86Hypermetropia (HP:0000540)1.57911370
87Optic nerve hypoplasia (HP:0000609)1.57769428
88Capillary hemangiomas (HP:0005306)1.57705342
89Poor coordination (HP:0002370)1.56243717
90Volvulus (HP:0002580)1.55692006
91Renal dysplasia (HP:0000110)1.54602528
92Increased CSF lactate (HP:0002490)1.54265763
93Psychosis (HP:0000709)1.54167432
94Tubulointerstitial nephritis (HP:0001970)1.52175338
95Clubbing of toes (HP:0100760)1.51428551
96Cupped ear (HP:0000378)1.51116762
97Abnormal urine phosphate concentration (HP:0012599)1.50679002
98Aplasia/Hypoplasia of the lens (HP:0008063)1.50338522
99Adrenal hypoplasia (HP:0000835)1.48539812
100Hyperkalemia (HP:0002153)1.46961113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE17.70739355
2BRSK14.94268709
3PBK3.57374382
4TAF13.18254496
5VRK22.82870698
6MAP3K102.52227083
7SMG12.45687385
8NEK92.13170845
9BRSK210.5461590
10PNCK1.80532662
11NUAK11.71927981
12BMPR1B1.48989821
13MKNK21.44148723
14CDK41.39210673
15CASK1.23499113
16CDC71.19896830
17EIF2AK21.16388732
18BUB11.08077290
19MST40.91924032
20VRK10.91124303
21MKNK10.86879199
22AURKA0.86646094
23CAMK1G0.86386476
24MELK0.82422016
25EPHB20.80645628
26ZAK0.78072697
27PLK10.77155221
28TNIK0.77043761
29EIF2AK10.75130322
30PLK40.70307733
31BRD40.67798294
32SCYL20.67770837
33MAPKAPK50.65306468
34PLK30.64928661
35DYRK30.64456912
36MAP3K130.62874142
37TTK0.61615801
38HIPK20.58009459
39MAP3K120.57127070
40WNK30.56812925
41WNK40.55752581
42CDK30.55353905
43PINK10.52331966
44UHMK10.50163337
45NEK20.49442757
46ACVR1B0.47131330
47NME10.46826615
48CSNK1G20.45196777
49GRK50.42917577
50CHEK20.41791089
51CSNK1A1L0.41053686
52RPS6KA40.39541967
53LATS10.38594619
54CSNK1G30.37474704
55CSNK1G10.37441030
56NEK10.36099160
57TSSK60.33589426
58CDK90.32181408
59ATR0.27560097
60CSNK1D0.26699060
61TAOK30.26259540
62MAP3K70.26122286
63RPS6KA10.25881926
64AURKB0.25853705
65SGK20.22860724
66FLT30.22639359
67EIF2AK30.21262204
68CDK70.19060937
69CAMKK20.16208460
70DYRK20.15779767
71YES10.14590469
72WNK10.13663059
73STK30.13471377
74STK110.12390920
75MAP4K20.11950054
76CDK80.11936176
77MAPK140.11051453
78PRKG10.10901208
79ATM0.10776202
80CDK10.10176020
81MAPK150.09479717
82GSK3A0.08743456
83CSNK2A10.07858800
84OXSR10.07065666
85CSNK1E0.06136731
86TEC0.05481495
87ADRBK20.05180607
88STK38L0.04547709
89CDK60.04224152
90TRPM70.04007477
91STK390.03791644
92DAPK30.03352043
93CDK20.03059186
94MAP3K140.01714488
95CDK50.00984818
96CSNK2A20.00947375
97PRKAA10.00688227
98ERBB40.00331822
99SGK10.00274859
100STK16-0.0077014

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of autophagy_Homo sapiens_hsa041405.52516069
2Cell cycle_Homo sapiens_hsa041104.81778197
3DNA replication_Homo sapiens_hsa030303.18212379
4Homologous recombination_Homo sapiens_hsa034403.16348404
5Mismatch repair_Homo sapiens_hsa034303.08392327
6Fanconi anemia pathway_Homo sapiens_hsa034602.23469109
7Nucleotide excision repair_Homo sapiens_hsa034202.15925239
8Base excision repair_Homo sapiens_hsa034102.15925227
9Steroid hormone biosynthesis_Homo sapiens_hsa001401.88181498
10RNA transport_Homo sapiens_hsa030131.87683209
11ABC transporters_Homo sapiens_hsa020101.85456076
12beta-Alanine metabolism_Homo sapiens_hsa004101.82580519
13mRNA surveillance pathway_Homo sapiens_hsa030151.81191631
14Basal transcription factors_Homo sapiens_hsa030221.77743614
15Glutathione metabolism_Homo sapiens_hsa004801.75649010
16RNA polymerase_Homo sapiens_hsa030201.73996464
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69438866
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55584563
19Chemical carcinogenesis_Homo sapiens_hsa052041.53917244
20Propanoate metabolism_Homo sapiens_hsa006401.47539218
21Inositol phosphate metabolism_Homo sapiens_hsa005621.46227317
22Basal cell carcinoma_Homo sapiens_hsa052171.45386439
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41566453
24Ribosome_Homo sapiens_hsa030101.41196120
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40560734
26p53 signaling pathway_Homo sapiens_hsa041151.38389479
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36692572
28Fatty acid degradation_Homo sapiens_hsa000711.30411593
29One carbon pool by folate_Homo sapiens_hsa006701.26286104
30TGF-beta signaling pathway_Homo sapiens_hsa043501.23911768
31Sulfur relay system_Homo sapiens_hsa041221.23201386
32Pyrimidine metabolism_Homo sapiens_hsa002401.20305874
33Non-homologous end-joining_Homo sapiens_hsa034501.09483942
34Fatty acid elongation_Homo sapiens_hsa000621.06839975
35Systemic lupus erythematosus_Homo sapiens_hsa053221.04699676
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04011222
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00182161
38Selenocompound metabolism_Homo sapiens_hsa004500.98242814
39Olfactory transduction_Homo sapiens_hsa047400.97954716
40Protein export_Homo sapiens_hsa030600.95479276
41Wnt signaling pathway_Homo sapiens_hsa043100.95400323
42RNA degradation_Homo sapiens_hsa030180.94775806
43Viral carcinogenesis_Homo sapiens_hsa052030.93485267
44Phototransduction_Homo sapiens_hsa047440.89898900
45Oocyte meiosis_Homo sapiens_hsa041140.88667729
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87980192
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87338915
48Lysine degradation_Homo sapiens_hsa003100.86298578
49Prostate cancer_Homo sapiens_hsa052150.85264306
50MicroRNAs in cancer_Homo sapiens_hsa052060.85242884
51Thyroid cancer_Homo sapiens_hsa052160.83654677
52Retinol metabolism_Homo sapiens_hsa008300.82557497
53Adherens junction_Homo sapiens_hsa045200.82003368
54Purine metabolism_Homo sapiens_hsa002300.80439107
55Fatty acid metabolism_Homo sapiens_hsa012120.79527299
56FoxO signaling pathway_Homo sapiens_hsa040680.78730205
57Alcoholism_Homo sapiens_hsa050340.74759493
58Type II diabetes mellitus_Homo sapiens_hsa049300.71901547
59Hedgehog signaling pathway_Homo sapiens_hsa043400.71443193
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69991049
61Huntingtons disease_Homo sapiens_hsa050160.68083210
62Spliceosome_Homo sapiens_hsa030400.65820378
63mTOR signaling pathway_Homo sapiens_hsa041500.64307927
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63955379
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62911251
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61229534
67Calcium signaling pathway_Homo sapiens_hsa040200.57852264
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.57148866
69Pancreatic cancer_Homo sapiens_hsa052120.56448407
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54196011
71Chronic myeloid leukemia_Homo sapiens_hsa052200.53810385
72Small cell lung cancer_Homo sapiens_hsa052220.52229638
73HTLV-I infection_Homo sapiens_hsa051660.49596143
74Pancreatic secretion_Homo sapiens_hsa049720.44231879
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43601002
76Glycerolipid metabolism_Homo sapiens_hsa005610.42837604
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41572430
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39135774
79Folate biosynthesis_Homo sapiens_hsa007900.39094223
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35507253
81Parkinsons disease_Homo sapiens_hsa050120.33297381
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33212747
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32195019
84Butanoate metabolism_Homo sapiens_hsa006500.31559786
85PPAR signaling pathway_Homo sapiens_hsa033200.29272564
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28111065
87Renin secretion_Homo sapiens_hsa049240.28033682
88Melanoma_Homo sapiens_hsa052180.27622345
89Notch signaling pathway_Homo sapiens_hsa043300.26468076
90Axon guidance_Homo sapiens_hsa043600.25483382
91Metabolic pathways_Homo sapiens_hsa011000.25400653
92Oxidative phosphorylation_Homo sapiens_hsa001900.24980647
93cAMP signaling pathway_Homo sapiens_hsa040240.24699477
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24476321
95Caffeine metabolism_Homo sapiens_hsa002320.24345670
96Colorectal cancer_Homo sapiens_hsa052100.23985805
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22198352
98Pathways in cancer_Homo sapiens_hsa052000.21105481
99Steroid biosynthesis_Homo sapiens_hsa001000.20055738
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18917296

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