FAM149A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cell size (GO:0045793)8.66512412
2arginine catabolic process (GO:0006527)8.25421921
3diaphragm development (GO:0060539)8.08670450
4exogenous drug catabolic process (GO:0042738)7.44295740
5skeletal muscle organ development (GO:0060538)7.37277533
6negative regulation of neurotransmitter transport (GO:0051589)7.24333323
7arginine metabolic process (GO:0006525)6.97336091
8positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)6.44477861
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.21189382
10negative regulation of calcium ion transport into cytosol (GO:0010523)5.93304388
11cellular protein complex localization (GO:0034629)5.83048590
12negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)5.76657754
13response to lipoprotein particle (GO:0055094)5.75079685
14negative regulation of peptidyl-threonine phosphorylation (GO:0010801)5.74137590
15pyrimidine nucleoside salvage (GO:0043097)5.69398747
16pyrimidine-containing compound salvage (GO:0008655)5.69398747
17regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.65894139
18negative regulation of vascular permeability (GO:0043116)5.62624750
19negative regulation of potassium ion transport (GO:0043267)5.26489823
20positive regulation of guanylate cyclase activity (GO:0031284)5.26487237
21regulation of neurotransmitter uptake (GO:0051580)5.25547113
22regulation of nuclear cell cycle DNA replication (GO:0033262)5.21520419
23pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)5.20461266
24UMP metabolic process (GO:0046049)5.20461266
25pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)5.20461266
26UMP biosynthetic process (GO:0006222)5.20461266
27L-phenylalanine catabolic process (GO:0006559)5.11316836
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.11316836
29L-phenylalanine metabolic process (GO:0006558)4.94319476
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.94319476
31regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)4.78766379
32regulation of guanylate cyclase activity (GO:0031282)4.77928671
33cysteine metabolic process (GO:0006534)4.77880021
34positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.46067862
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.42121491
36intestinal cholesterol absorption (GO:0030299)4.36380823
37positive regulation of sodium ion transmembrane transport (GO:1902307)4.28776179
38aromatic amino acid family catabolic process (GO:0009074)4.21474920
39lateral sprouting from an epithelium (GO:0060601)4.09700951
40negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.04073761
41homocysteine metabolic process (GO:0050667)3.97917474
42pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.96359848
43regulation of stem cell maintenance (GO:2000036)3.96250602
44nitric oxide mediated signal transduction (GO:0007263)3.93502908
45neurotransmitter biosynthetic process (GO:0042136)3.91202501
46substrate-independent telencephalic tangential migration (GO:0021826)3.90455420
47substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.90455420
48nucleotide salvage (GO:0043173)3.88337756
49regulation of cholesterol biosynthetic process (GO:0045540)3.85130342
50sulfur amino acid catabolic process (GO:0000098)3.84495350
51cellular modified amino acid catabolic process (GO:0042219)3.80568942
52nitric oxide biosynthetic process (GO:0006809)3.79753395
53protein heterotrimerization (GO:0070208)3.78656673
54positive regulation of signal transduction by p53 class mediator (GO:1901798)3.73876021
55positive regulation of catecholamine secretion (GO:0033605)3.73875767
56regulation of cilium movement (GO:0003352)3.73176770
57lysine metabolic process (GO:0006553)3.72102868
58lysine catabolic process (GO:0006554)3.72102868
59negative regulation of protein kinase B signaling (GO:0051898)3.70147312
60glyoxylate metabolic process (GO:0046487)3.68776150
61alpha-linolenic acid metabolic process (GO:0036109)3.68660904
62pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.68629097
63nucleoside salvage (GO:0043174)3.66969092
64histone H3-K4 methylation (GO:0051568)3.65226455
65bile acid biosynthetic process (GO:0006699)3.61838162
66triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.60415194
67determination of left/right symmetry (GO:0007368)3.60382245
68protein complex localization (GO:0031503)3.58431235
69amino-acid betaine metabolic process (GO:0006577)3.57328375
70nerve growth factor signaling pathway (GO:0038180)3.56279565
71negative regulation of macrophage differentiation (GO:0045650)3.54250347
72negative regulation of fibrinolysis (GO:0051918)3.54095432
73regulation of mitochondrial translation (GO:0070129)3.53848810
74negative regulation of potassium ion transmembrane transport (GO:1901380)3.51063749
75regulation of synaptic vesicle transport (GO:1902803)3.45994341
76regulation of cilium assembly (GO:1902017)3.45274496
77negative regulation of neurotransmitter secretion (GO:0046929)3.45133001
78determination of bilateral symmetry (GO:0009855)3.44257917
79protein carboxylation (GO:0018214)3.43604903
80peptidyl-glutamic acid carboxylation (GO:0017187)3.43604903
81respiratory chain complex IV assembly (GO:0008535)3.42438843
82positive regulation of cGMP biosynthetic process (GO:0030828)3.40356623
83activation of MAPKKK activity (GO:0000185)3.39345855
84tryptophan catabolic process (GO:0006569)3.39171106
85indole-containing compound catabolic process (GO:0042436)3.39171106
86indolalkylamine catabolic process (GO:0046218)3.39171106
87positive regulation of receptor biosynthetic process (GO:0010870)3.36533516
88specification of symmetry (GO:0009799)3.36272219
89kynurenine metabolic process (GO:0070189)3.35365193
903-UTR-mediated mRNA stabilization (GO:0070935)3.34495380
91axonemal dynein complex assembly (GO:0070286)3.31772729
92DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.30240419
93myoblast fusion (GO:0007520)3.30179262
94epithelial cilium movement (GO:0003351)3.29269116
95regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.28569630
96positive regulation of DNA-dependent DNA replication (GO:2000105)3.28141686
97tryptophan metabolic process (GO:0006568)3.27996711
98short-chain fatty acid metabolic process (GO:0046459)3.26544055
99glutamate metabolic process (GO:0006536)3.25856558
100coenzyme catabolic process (GO:0009109)3.24824278
101chromatin silencing (GO:0006342)3.23655102
102oogenesis (GO:0048477)3.23195692
103serine family amino acid catabolic process (GO:0009071)3.22031014
104peptidyl-cysteine modification (GO:0018198)3.21098556
105regulation of cGMP biosynthetic process (GO:0030826)3.19484404
106protein retention in ER lumen (GO:0006621)3.19159595
107regulation of mRNA catabolic process (GO:0061013)3.17484084
108axonal fasciculation (GO:0007413)3.17230007
109regulation of fibrinolysis (GO:0051917)3.15254849
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.14858369
111negative regulation of granulocyte differentiation (GO:0030853)3.14837827
112aspartate family amino acid catabolic process (GO:0009068)3.14284022
113fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.13284987
114high-density lipoprotein particle remodeling (GO:0034375)3.12182903
115cellular ketone body metabolic process (GO:0046950)3.11572994
116alpha-amino acid catabolic process (GO:1901606)3.10362006
117establishment of planar polarity (GO:0001736)3.09988973
118establishment of tissue polarity (GO:0007164)3.09988973
119aromatic amino acid family metabolic process (GO:0009072)3.08743425
120CTP metabolic process (GO:0046036)3.07266715
121CTP biosynthetic process (GO:0006241)3.07266715
122cellular amino acid catabolic process (GO:0009063)3.05567909
123exocrine pancreas development (GO:0031017)3.05275661
124regulation of protein activation cascade (GO:2000257)3.05265994
125reverse cholesterol transport (GO:0043691)3.02552819
126positive regulation of mRNA catabolic process (GO:0061014)2.99032060
127bile acid metabolic process (GO:0008206)2.97893547
128transcytosis (GO:0045056)2.97771374
129carnitine metabolic process (GO:0009437)2.97145346
130sodium-independent organic anion transport (GO:0043252)2.97004727
131regulation of oxidative phosphorylation (GO:0002082)2.96620349
132tyrosine metabolic process (GO:0006570)2.95746388
133regulation of protein deacetylation (GO:0090311)2.94391392
134positive regulation of cGMP metabolic process (GO:0030825)2.94078258
135cellular glucuronidation (GO:0052695)2.93171658
136negative regulation of T cell receptor signaling pathway (GO:0050860)2.92999352
137positive regulation of fatty acid beta-oxidation (GO:0032000)2.92260927
138cilium movement (GO:0003341)2.92103824
139regulation of complement activation (GO:0030449)2.91385850
140dicarboxylic acid biosynthetic process (GO:0043650)2.90958438
141negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.90687700
142urea cycle (GO:0000050)2.89781973
143urea metabolic process (GO:0019627)2.89781973
144DNA damage response, signal transduction resulting in transcription (GO:0042772)2.89732151
145regulation of synaptic vesicle exocytosis (GO:2000300)2.88269448
146complement activation, alternative pathway (GO:0006957)2.86765270
147protein-lipid complex remodeling (GO:0034368)2.84382343
148macromolecular complex remodeling (GO:0034367)2.84382343
149plasma lipoprotein particle remodeling (GO:0034369)2.84382343
150glycerophospholipid catabolic process (GO:0046475)2.82859835
151negative regulation of alcohol biosynthetic process (GO:1902931)2.81793489
152serine family amino acid metabolic process (GO:0009069)2.78496176
153dicarboxylic acid catabolic process (GO:0043649)2.76176114
154regulation of cholesterol homeostasis (GO:2000188)2.74348000
155glucuronate metabolic process (GO:0019585)2.74058868
156uronic acid metabolic process (GO:0006063)2.74058868
157purine nucleotide transport (GO:0015865)2.72147710
158ethanol oxidation (GO:0006069)2.71152736
159drug transmembrane transport (GO:0006855)2.71002856
160ketone body metabolic process (GO:1902224)2.70756874
161epoxygenase P450 pathway (GO:0019373)2.70187231
162regulation of fatty acid beta-oxidation (GO:0031998)2.68890355
163nitrogen cycle metabolic process (GO:0071941)2.67595232
1644-hydroxyproline metabolic process (GO:0019471)2.66865815
165acylglycerol homeostasis (GO:0055090)2.64852626
166triglyceride homeostasis (GO:0070328)2.64852626
167gap junction assembly (GO:0016264)2.61976047
168drug catabolic process (GO:0042737)2.61644826
169sterol catabolic process (GO:0016127)2.61199034
170cholesterol catabolic process (GO:0006707)2.61199034
171carboxylic acid catabolic process (GO:0046395)2.60967994
172organic acid catabolic process (GO:0016054)2.60967994
173fibrinolysis (GO:0042730)2.57437763
174lipoprotein metabolic process (GO:0042157)2.55813747
175positive regulation of fatty acid oxidation (GO:0046321)2.55509802
176low-density lipoprotein particle remodeling (GO:0034374)2.55245877
177regulation of plasminogen activation (GO:0010755)2.54987504
178lipid oxidation (GO:0034440)2.53796456
179regulation of phospholipase A2 activity (GO:0032429)2.52602853
180benzene-containing compound metabolic process (GO:0042537)2.51162150
181negative regulation of cholesterol transport (GO:0032375)2.50869748
182negative regulation of sterol transport (GO:0032372)2.50869748
183fatty acid oxidation (GO:0019395)2.49353708
184indolalkylamine metabolic process (GO:0006586)2.48565319
185monocarboxylic acid catabolic process (GO:0072329)2.47881315
1862-oxoglutarate metabolic process (GO:0006103)2.46220169
187COPI coating of Golgi vesicle (GO:0048205)2.45667840
188Golgi transport vesicle coating (GO:0048200)2.45667840
189valine metabolic process (GO:0006573)2.44951909
190intestinal absorption (GO:0050892)2.44777280
191adenine nucleotide transport (GO:0051503)2.43624938
192purine ribonucleotide transport (GO:0015868)2.43560696
193urate metabolic process (GO:0046415)2.43546781
194positive regulation of lipid catabolic process (GO:0050996)2.43249146
195fatty acid beta-oxidation (GO:0006635)2.42722551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.59443726
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.21111295
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.59686326
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.47283773
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83933700
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.71405185
7ZNF274_21170338_ChIP-Seq_K562_Hela2.45827875
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.33574907
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27444200
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27077680
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.24896824
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.15928135
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.14581586
14CLOCK_20551151_ChIP-Seq_293T_Human1.95508493
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93708383
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90870002
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74328994
18TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.72557286
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69547592
20NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67927870
21NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67927870
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61658094
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56692340
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55995423
25REST_21632747_ChIP-Seq_MESCs_Mouse1.55552893
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52684729
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.49515476
28P53_22127205_ChIP-Seq_FIBROBLAST_Human1.49042617
29* FOXA2_19822575_ChIP-Seq_HepG2_Human1.47775304
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47545228
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46535320
32SMAD3_21741376_ChIP-Seq_ESCs_Human1.44692975
33CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.43119227
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42283994
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41744401
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39504796
37FUS_26573619_Chip-Seq_HEK293_Human1.39477582
38ZNF263_19887448_ChIP-Seq_K562_Human1.39463430
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.39030421
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38351434
41TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.38303211
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37431240
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.37356333
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35905373
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.35789500
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34384691
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33951424
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33951424
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.33433689
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33190367
51TP53_18474530_ChIP-ChIP_U2OS_Human1.32873645
52RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30677196
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.30513543
54DROSHA_22980978_ChIP-Seq_HELA_Human1.30372033
55RNF2_27304074_Chip-Seq_NSC_Mouse1.29888542
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29432025
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27588130
58TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27219505
59MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26259745
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24955224
61AR_25329375_ChIP-Seq_VCAP_Human1.24928864
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.24637221
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23958156
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.23441263
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23189210
66TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20324058
67STAT3_23295773_ChIP-Seq_U87_Human1.19459458
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19154831
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.17367228
70TCF4_22108803_ChIP-Seq_LS180_Human1.17223470
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16166827
72TAF15_26573619_Chip-Seq_HEK293_Human1.15460290
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.15223385
74GBX2_23144817_ChIP-Seq_PC3_Human1.14923118
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12572020
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12395042
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12287436
78CJUN_26792858_Chip-Seq_BT549_Human1.11877758
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11625719
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11486359
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.11393463
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11239888
83SOX2_20726797_ChIP-Seq_SW620_Human1.10790982
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10767986
85BCAT_22108803_ChIP-Seq_LS180_Human1.10393036
86* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10130847
87RUNX_20019798_ChIP-Seq_JUKART_Human1.09990607
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09271917
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.08795673
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07675760
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05264402
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04154238
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.03626243
94P300_19829295_ChIP-Seq_ESCs_Human1.02614494
95SCL_19346495_ChIP-Seq_HPC-7_Human1.01929548
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01379678
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00655878
98* TCF4_23295773_ChIP-Seq_U87_Human1.00470565
99RXR_22108803_ChIP-Seq_LS180_Human0.99483491
100EZH2_22144423_ChIP-Seq_EOC_Human0.99193277
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98826685
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98431891
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98164728
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98061598
105OCT1_27270436_Chip-Seq_PROSTATE_Human0.97744921
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97307269
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97077604
108SMC4_20622854_ChIP-Seq_HELA_Human0.96580790
109AHR_22903824_ChIP-Seq_MCF-7_Human0.96316535
110POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95774863
111HNF4A_19822575_ChIP-Seq_HepG2_Human0.95584868
112CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95535808
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93619117
114VDR_22108803_ChIP-Seq_LS180_Human0.93126750
115JUN_21703547_ChIP-Seq_K562_Human0.92946945
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.92594302
117CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91405165
118SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91340086
119WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91287222
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90670341
121GATA1_22025678_ChIP-Seq_K562_Human0.90535518
122AR_21572438_ChIP-Seq_LNCaP_Human0.89420308
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88377122
124JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87887925
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87765557
126EZH2_27304074_Chip-Seq_ESCs_Mouse0.87116821
127* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86967901
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86843033
129KDM2B_26808549_Chip-Seq_K562_Human0.86740222
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86719903
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86719903
132SMAD4_21799915_ChIP-Seq_A2780_Human0.86308504
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.86033342
134SOX2_21211035_ChIP-Seq_LN229_Gbm0.85532433
135GATA4_25053715_ChIP-Seq_YYC3_Human0.85034638
136AR_19668381_ChIP-Seq_PC3_Human0.84464733
137RNF2_27304074_Chip-Seq_ESCs_Mouse0.82429645
138ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81936937
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81894155
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81490978
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80374089
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80224218
143WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79816352
144TP63_23658742_ChIP-Seq_EP156T_Human0.79311738
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78849222
146TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75500048
147ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74595397
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.74533352
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.74126315
150WT1_19549856_ChIP-ChIP_CCG9911_Human0.73631738
151ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72876320
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.72714249
153CBP_20019798_ChIP-Seq_JUKART_Human0.72714249
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72555681
155SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71544831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis7.25066462
2MP0003646_muscle_fatigue7.15832041
3MP0002139_abnormal_hepatobiliary_system5.43878069
4MP0002234_abnormal_pharynx_morphology5.27403369
5MP0005365_abnormal_bile_salt4.60564095
6MP0005360_urolithiasis4.44584892
7MP0005085_abnormal_gallbladder_physiolo4.30463698
8MP0005645_abnormal_hypothalamus_physiol3.91925383
9MP0005083_abnormal_biliary_tract3.88785140
10MP0001666_abnormal_nutrient_absorption3.49373288
11MP0003252_abnormal_bile_duct3.21839845
12MP0008875_abnormal_xenobiotic_pharmacok2.84355131
13MP0003705_abnormal_hypodermis_morpholog2.79564608
14MP0003011_delayed_dark_adaptation2.63490170
15MP0009780_abnormal_chondrocyte_physiolo2.58551099
16MP0009384_cardiac_valve_regurgitation2.50031103
17MP0004084_abnormal_cardiac_muscle2.38546953
18MP0010329_abnormal_lipoprotein_level2.33859476
19MP0008438_abnormal_cutaneous_collagen2.33710250
20MP0003868_abnormal_feces_composition2.25488869
21MP0005084_abnormal_gallbladder_morpholo2.19199615
22MP0005220_abnormal_exocrine_pancreas2.17678246
23MP0003718_maternal_effect2.09337578
24MP0003195_calcinosis2.09316784
25MP0005332_abnormal_amino_acid2.06411494
26MP0003880_abnormal_central_pattern1.99827143
27MP0001501_abnormal_sleep_pattern1.93889159
28MP0003806_abnormal_nucleotide_metabolis1.88746641
29MP0005551_abnormal_eye_electrophysiolog1.82599987
30MP0002138_abnormal_hepatobiliary_system1.76281387
31MP0004019_abnormal_vitamin_homeostasis1.73440424
32MP0002233_abnormal_nose_morphology1.66935700
33MP0006082_CNS_inflammation1.61871228
34MP0008872_abnormal_physiological_respon1.60779619
35MP0001919_abnormal_reproductive_system1.54301994
36MP0000467_abnormal_esophagus_morphology1.53870527
37MP0002118_abnormal_lipid_homeostasis1.49469113
38MP0003279_aneurysm1.48242471
39MP0001984_abnormal_olfaction1.43447445
40MP0008775_abnormal_heart_ventricle1.42993926
41MP0009745_abnormal_behavioral_response1.40001661
42MP0005423_abnormal_somatic_nervous1.39784570
43MP0002876_abnormal_thyroid_physiology1.39109077
44MP0004858_abnormal_nervous_system1.36566280
45MP0004036_abnormal_muscle_relaxation1.33060511
46MP0010234_abnormal_vibrissa_follicle1.27717623
47MP0001542_abnormal_bone_strength1.27413939
48MP0009840_abnormal_foam_cell1.24042753
49MP0004133_heterotaxia1.23305976
50MP0003123_paternal_imprinting1.23290429
51MP0005275_abnormal_skin_tensile1.23266479
52MP0002928_abnormal_bile_duct1.23118338
53MP0002896_abnormal_bone_mineralization1.22168112
54MP0002272_abnormal_nervous_system1.21636184
55MP0009053_abnormal_anal_canal1.20830354
56MP0000955_abnormal_spinal_cord1.19222717
57MP0001440_abnormal_grooming_behavior1.18665871
58MP0005503_abnormal_tendon_morphology1.18143376
59MP0000631_abnormal_neuroendocrine_gland1.14512331
60MP0006138_congestive_heart_failure1.11778727
61MP0002064_seizures1.11431819
62MP0005394_taste/olfaction_phenotype1.11149802
63MP0005499_abnormal_olfactory_system1.11149802
64MP0004272_abnormal_basement_membrane1.10330516
65MP0001879_abnormal_lymphatic_vessel1.09703656
66MP0001958_emphysema1.09333905
67MP0009643_abnormal_urine_homeostasis1.08512575
68MP0000733_abnormal_muscle_development1.06390983
69MP0000609_abnormal_liver_physiology1.04880707
70MP0004484_altered_response_of1.04562728
71MP0003283_abnormal_digestive_organ1.02392904
72MP0000013_abnormal_adipose_tissue1.01812698
73MP0002063_abnormal_learning/memory/cond1.01686399
74MP0005646_abnormal_pituitary_gland1.01678770
75MP0004885_abnormal_endolymph1.00239024
76MP0010307_abnormal_tumor_latency0.99667417
77MP0002090_abnormal_vision0.99208391
78MP0005389_reproductive_system_phenotype0.97101198
79MP0002009_preneoplasia0.97034084
80MP0001944_abnormal_pancreas_morphology0.96266327
81MP0003937_abnormal_limbs/digits/tail_de0.95152368
82MP0002295_abnormal_pulmonary_circulatio0.94125042
83MP0005623_abnormal_meninges_morphology0.93881527
84MP0003635_abnormal_synaptic_transmissio0.93417178
85MP0003633_abnormal_nervous_system0.93044683
86MP0008789_abnormal_olfactory_epithelium0.92989790
87MP0000470_abnormal_stomach_morphology0.92656535
88MP0004043_abnormal_pH_regulation0.92385958
89MP0002168_other_aberrant_phenotype0.92082306
90MP0005253_abnormal_eye_physiology0.91578126
91MP0002127_abnormal_cardiovascular_syste0.89537180
92MP0005319_abnormal_enzyme/_coenzyme0.88860072
93MP0001764_abnormal_homeostasis0.88104070
94MP0000537_abnormal_urethra_morphology0.87901212
95MP0002116_abnormal_craniofacial_bone0.87572969
96MP0002109_abnormal_limb_morphology0.86733129
97MP0002572_abnormal_emotion/affect_behav0.84347816
98MP0003942_abnormal_urinary_system0.84338319
99MP0003690_abnormal_glial_cell0.83841690
100MP0005670_abnormal_white_adipose0.83615593
101MP0009046_muscle_twitch0.83066623
102MP0005076_abnormal_cell_differentiation0.82447588
103MP0005584_abnormal_enzyme/coenzyme_acti0.81892225
104MP0003959_abnormal_lean_body0.81509884
105MP0000383_abnormal_hair_follicle0.80852432
106MP0001756_abnormal_urination0.79987443
107MP0004233_abnormal_muscle_weight0.78369373
108MP0008877_abnormal_DNA_methylation0.78246322
109MP0005408_hypopigmentation0.76733846
110MP0005248_abnormal_Harderian_gland0.76337575
111MP0003631_nervous_system_phenotype0.76275970
112MP0002078_abnormal_glucose_homeostasis0.76131858
113MP0000778_abnormal_nervous_system0.76131107
114MP0002184_abnormal_innervation0.76068416
115MP0002909_abnormal_adrenal_gland0.75970795
116MP0004811_abnormal_neuron_physiology0.75695846
117MP0010368_abnormal_lymphatic_system0.75114467
118MP0005195_abnormal_posterior_eye0.74553583
119MP0003119_abnormal_digestive_system0.73713899
120MP0003329_amyloid_beta_deposits0.73108837
121MP0002557_abnormal_social/conspecific_i0.72989154
122MP0001324_abnormal_eye_pigmentation0.70992182
123MP0001970_abnormal_pain_threshold0.70373257
124MP0005167_abnormal_blood-brain_barrier0.68550319
125MP0000003_abnormal_adipose_tissue0.68532121
126MP0008004_abnormal_stomach_pH0.68221683
127MP0004130_abnormal_muscle_cell0.68172409
128MP0005187_abnormal_penis_morphology0.67972576
129MP0001177_atelectasis0.67454006
130MP0004859_abnormal_synaptic_plasticity0.66300592
131MP0001502_abnormal_circadian_rhythm0.66288014
132MP0000432_abnormal_head_morphology0.65054381
133MP0005448_abnormal_energy_balance0.64627248
134MP0006072_abnormal_retinal_apoptosis0.64271587
135MP0001664_abnormal_digestion0.64238786
136MP0005535_abnormal_body_temperature0.63851615
137MP0002734_abnormal_mechanical_nocicepti0.63522561
138MP0000534_abnormal_ureter_morphology0.63347371
139MP0001486_abnormal_startle_reflex0.61113137
140MP0003879_abnormal_hair_cell0.60815840
141MP0000163_abnormal_cartilage_morphology0.60580040
142MP0005058_abnormal_lysosome_morphology0.60214427
143MP0001299_abnormal_eye_distance/0.60201511
144MP0005395_other_phenotype0.59936994
145MP0005595_abnormal_vascular_smooth0.59508121
146MP0003045_fibrosis0.58670260
147MP0005636_abnormal_mineral_homeostasis0.57135665
148MP0003634_abnormal_glial_cell0.56062377
149MP0002067_abnormal_sensory_capabilities0.54696384
150MP0005508_abnormal_skeleton_morphology0.54337224
151MP0010678_abnormal_skin_adnexa0.54069938
152MP0004883_abnormal_blood_vessel0.53954403
153MP0002837_dystrophic_cardiac_calcinosis0.53925870
154MP0004270_analgesia0.53898487
155MP0002822_catalepsy0.53516614
156MP0000598_abnormal_liver_morphology0.53409966
157MP0002735_abnormal_chemical_nociception0.52626837
158MP0002877_abnormal_melanocyte_morpholog0.52476201
159MP0005197_abnormal_uvea_morphology0.52390197
160MP0000767_abnormal_smooth_muscle0.51802648
161MP0000538_abnormal_urinary_bladder0.50315187
162MP0002229_neurodegeneration0.49954173
163MP0003953_abnormal_hormone_level0.49729990
164MP0002882_abnormal_neuron_morphology0.49044424
165MP0001485_abnormal_pinna_reflex0.48821166
166MP0009764_decreased_sensitivity_to0.47876354
167MP0001765_abnormal_ion_homeostasis0.47297488
168MP0000230_abnormal_systemic_arterial0.46719864
169MP0008961_abnormal_basal_metabolism0.46441008
170MP0005334_abnormal_fat_pad0.46325133
171MP0002932_abnormal_joint_morphology0.46304637
172MP0006276_abnormal_autonomic_nervous0.46233409

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)7.83924191
2Autoimmune thrombocytopenia (HP:0001973)6.81029348
3Anal stenosis (HP:0002025)6.72481572
4Sparse lateral eyebrow (HP:0005338)6.71408311
5Depressed nasal tip (HP:0000437)6.02130732
6Intestinal fistula (HP:0100819)5.69342402
7Abnormality of the fingertips (HP:0001211)5.23112610
8Ureteral stenosis (HP:0000071)4.83167882
9Short 5th finger (HP:0009237)4.67164550
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.57800542
11Deep venous thrombosis (HP:0002625)4.48598700
12Ureteral obstruction (HP:0006000)4.45841565
13Aplasia/Hypoplasia of the 5th finger (HP:0006262)4.36623531
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.28835914
15Popliteal pterygium (HP:0009756)4.27701209
16Lower limb hyperreflexia (HP:0002395)4.16998393
17Intrahepatic cholestasis (HP:0001406)4.13584914
18Xanthomatosis (HP:0000991)3.96043037
19Ectopic kidney (HP:0000086)3.85687774
20Preauricular pit (HP:0004467)3.68996980
21Periauricular skin pits (HP:0100277)3.68996980
22Gout (HP:0001997)3.60557413
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.36408829
24Hyperlipoproteinemia (HP:0010980)3.33720574
25Chorioretinal atrophy (HP:0000533)3.32675712
26Posterior subcapsular cataract (HP:0007787)3.25402381
27Hypoalphalipoproteinemia (HP:0003233)3.23513934
28Hyperglycinemia (HP:0002154)3.16545569
29Abnormal respiratory motile cilium morphology (HP:0005938)3.14013101
30Abnormal respiratory epithelium morphology (HP:0012253)3.14013101
31Atonic seizures (HP:0010819)3.11622375
32Ketosis (HP:0001946)3.08054066
33Ketoacidosis (HP:0001993)3.05805465
34Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.04356212
35Vertebral hypoplasia (HP:0008417)3.04356212
36Hypolipoproteinemia (HP:0010981)2.95507402
37Hypobetalipoproteinemia (HP:0003563)2.95139326
38Aplasia involving bones of the upper limbs (HP:0009823)2.93385443
39Aplasia of the phalanges of the hand (HP:0009802)2.93385443
40Aplasia involving bones of the extremities (HP:0009825)2.93385443
41Mucopolysacchariduria (HP:0008155)2.92769936
42Urinary glycosaminoglycan excretion (HP:0003541)2.92769936
43Pigmentary retinal degeneration (HP:0001146)2.91209345
44Abnormality of the renal cortex (HP:0011035)2.90151057
45Protrusio acetabuli (HP:0003179)2.89610469
46Fat malabsorption (HP:0002630)2.83679892
47Polydipsia (HP:0001959)2.82728825
48Abnormal drinking behavior (HP:0030082)2.82728825
49Abnormality of the common coagulation pathway (HP:0010990)2.81837821
50Complement deficiency (HP:0004431)2.77961571
51Abnormality of serine family amino acid metabolism (HP:0010894)2.77944884
52Abnormality of glycine metabolism (HP:0010895)2.77944884
53Chronic bronchitis (HP:0004469)2.76192154
54Tubular atrophy (HP:0000092)2.75985515
55Hyperglycinuria (HP:0003108)2.74917253
56Prolonged partial thromboplastin time (HP:0003645)2.74808535
57Pancreatic cysts (HP:0001737)2.74637760
58Hyperammonemia (HP:0001987)2.74228564
59Central scotoma (HP:0000603)2.71264130
60Abnormality of glutamine family amino acid metabolism (HP:0010902)2.71209551
61Abnormality of the intrinsic pathway (HP:0010989)2.70930534
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.66830271
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.66830271
64Abnormality of polysaccharide metabolism (HP:0011012)2.66830271
65Abnormal respiratory motile cilium physiology (HP:0012261)2.64073952
66Pheochromocytoma (HP:0002666)2.63520165
67Bony spicule pigmentary retinopathy (HP:0007737)2.63055890
68Absent eyebrow (HP:0002223)2.60165804
69Facial cleft (HP:0002006)2.58060885
70Abnormality of macular pigmentation (HP:0008002)2.54048923
71Dyschromatopsia (HP:0007641)2.53434684
72Long palpebral fissure (HP:0000637)2.53124061
73Cardiovascular calcification (HP:0011915)2.50038561
74Preaxial foot polydactyly (HP:0001841)2.49848417
75Skin pits (HP:0100276)2.49277185
76Natal tooth (HP:0000695)2.49088483
77Premature rupture of membranes (HP:0001788)2.48659136
78Rhinitis (HP:0012384)2.47821247
79Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.47519899
80Wide intermamillary distance (HP:0006610)2.46641068
81Hypoplastic labia majora (HP:0000059)2.46166366
82Ectropion (HP:0000656)2.44670638
83Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42444777
84Mask-like facies (HP:0000298)2.39749522
85Vascular calcification (HP:0004934)2.39460930
86Abnormality of purine metabolism (HP:0004352)2.37973096
87Hypoglycemic coma (HP:0001325)2.36462022
88Sensorimotor neuropathy (HP:0007141)2.36032858
89Frequent falls (HP:0002359)2.35683478
90Abnormality of the periventricular white matter (HP:0002518)2.34749742
91Congenital stationary night blindness (HP:0007642)2.33543638
92Abnormality of sulfur amino acid metabolism (HP:0004339)2.32716288
93Recurrent otitis media (HP:0000403)2.32404305
94Self-mutilation (HP:0000742)2.29574610
95Abnormality of the distal phalanges of the toes (HP:0010182)2.29045969
96Epidermoid cyst (HP:0200040)2.27206471
97Hepatocellular carcinoma (HP:0001402)2.26667015
98Neuroendocrine neoplasm (HP:0100634)2.26380581
99Generalized aminoaciduria (HP:0002909)2.25822144
100Hypercholesterolemia (HP:0003124)2.24712550
101Steatorrhea (HP:0002570)2.23478172
102Abnormality of the labia majora (HP:0012881)2.22863642
103Absent eyelashes (HP:0000561)2.22552014
104Confusion (HP:0001289)2.21328257
105Non-midline cleft lip (HP:0100335)2.21280876
106Blue irides (HP:0000635)2.20631698
107Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18981519
108Hypoglycemic seizures (HP:0002173)2.13452072
109Narrow palate (HP:0000189)2.11872909
110Increased purine levels (HP:0004368)2.11634233
111Hyperuricemia (HP:0002149)2.11634233
112Scotoma (HP:0000575)2.11489039
113Abolished electroretinogram (ERG) (HP:0000550)2.10781473
114Back pain (HP:0003418)2.08981355
115Absence seizures (HP:0002121)2.07564074
116Broad hallux (HP:0010055)2.06925427
117Polyuria (HP:0000103)2.06684814
118Fibular aplasia (HP:0002990)2.06085035
119Neonatal onset (HP:0003623)2.05466409
120Uterine leiomyosarcoma (HP:0002891)2.05060403
121Leiomyosarcoma (HP:0100243)2.05060403
122Anal atresia (HP:0002023)2.02644380
123Bronchiectasis (HP:0002110)2.00367325
124Broad thumb (HP:0011304)1.95981305
125Abnormality of complement system (HP:0005339)1.95238450
126Tetraparesis (HP:0002273)1.94672478
127Febrile seizures (HP:0002373)1.94282239
128Absent thumb (HP:0009777)1.94133695
129Delayed CNS myelination (HP:0002188)1.94100828
130Conjugated hyperbilirubinemia (HP:0002908)1.93692639
131Skin nodule (HP:0200036)1.93142164
132Enlarged kidneys (HP:0000105)1.92957655
133Cone-rod dystrophy (HP:0000548)1.92627990
134Neonatal death (HP:0003811)1.91019695
135Tubulointerstitial abnormality (HP:0001969)1.83784069
136Abnormal rod and cone electroretinograms (HP:0008323)1.83375601
137Abnormality of dentin (HP:0010299)1.83096409
138Infantile muscular hypotonia (HP:0008947)1.82493011
139Abnormality of cochlea (HP:0000375)1.81977543
140Abnormality of fatty-acid metabolism (HP:0004359)1.81798146
141Transitional cell carcinoma of the bladder (HP:0006740)1.81698437
142Dialeptic seizures (HP:0011146)1.81556252
143Renal cell carcinoma (HP:0005584)1.80976595
144Turricephaly (HP:0000262)1.80721941
145Pterygium (HP:0001059)1.80138637
146Status epilepticus (HP:0002133)1.79726202
147Pancreatic fibrosis (HP:0100732)1.78803925
148Myocardial infarction (HP:0001658)1.78063406
149Retinal atrophy (HP:0001105)1.77457511
150Joint hemorrhage (HP:0005261)1.77426159
151Long toe (HP:0010511)1.76767838
152Short 1st metacarpal (HP:0010034)1.76765544
153Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.76765544
154Severe visual impairment (HP:0001141)1.76641576
155Lymphangioma (HP:0100764)1.76230197
156Dynein arm defect of respiratory motile cilia (HP:0012255)1.75404876
157Absent/shortened dynein arms (HP:0200106)1.75404876
158Abnormal urine output (HP:0012590)1.74972078
159Potter facies (HP:0002009)1.74829010
160Facial shape deformation (HP:0011334)1.74829010
161Congenital hip dislocation (HP:0001374)1.74770531
162Renal cortical cysts (HP:0000803)1.74325941
163Spastic diplegia (HP:0001264)1.73555647
164Abnormality of nucleobase metabolism (HP:0010932)1.73539487
165Pachygyria (HP:0001302)1.73321404
166Obstructive sleep apnea (HP:0002870)1.72868832
167Mitral stenosis (HP:0001718)1.71535170
168Tubulointerstitial fibrosis (HP:0005576)1.70218395
169Abnormality of methionine metabolism (HP:0010901)1.68416404
170Malnutrition (HP:0004395)1.68163578
171Peritonitis (HP:0002586)1.67278330
172Alkalosis (HP:0001948)1.67144437
173Overgrowth (HP:0001548)1.65721870
174Tubulointerstitial nephritis (HP:0001970)1.65048812
175Increased CSF protein (HP:0002922)1.62142081
176Neonatal short-limb short stature (HP:0008921)1.59614146
177Vitreoretinal degeneration (HP:0000655)1.58767058
178Broad metatarsal (HP:0001783)1.58359103
179Congenital glaucoma (HP:0001087)1.57470849
180Glomerulosclerosis (HP:0000096)1.56056556
181Abnormal tarsal ossification (HP:0008369)1.55565090
182Hepatoblastoma (HP:0002884)1.55546903
183Choroideremia (HP:0001139)1.54644193
184Chronic hepatic failure (HP:0100626)1.54109572
185Esophageal varix (HP:0002040)1.53887566
186Late onset (HP:0003584)1.53822168
187Metabolic acidosis (HP:0001942)1.52507562
188Dysostosis multiplex (HP:0000943)1.52408963
189Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.52349302
190Blue sclerae (HP:0000592)1.50999363

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK248.04648896
2PINK14.42093052
3CCNB14.08908799
4TRIB33.37629880
5EEF2K3.26598359
6FRK3.16221692
7BCKDK3.09971978
8MAP3K22.64112928
9SIK12.58747733
10ZAK2.37498560
11MAPKAPK32.27065521
12ERN12.21569168
13LATS22.18426426
14JAK32.12880373
15ILK2.03894651
16WNK42.00360413
17LATS11.95909316
18PKN21.94469329
19FER1.88390456
20DDR21.82969311
21PDGFRA1.79493215
22PAK31.74208852
23PTK21.71988219
24CAMK11.70296377
25NTRK21.69855627
26MAP2K41.63113796
27CAMK41.61885224
28IRAK21.60607766
29CAMKK11.55945464
30GRK11.54946868
31RIPK11.50943498
32PRKD31.43820415
33NTRK11.41188520
34CAMK1G1.40996374
35PTK61.38901232
36MST1R1.32816448
37MINK11.31578523
38MAPK121.31058377
39CAMK1D1.30854173
40FGFR21.30830914
41INSRR1.30225077
42TNIK1.26920464
43MAP3K41.25268223
44PNCK1.23663908
45PRKCQ1.23494194
46TRPM71.22298791
47MAPK151.20402146
48DAPK21.18210638
49MAP2K11.16355559
50RPS6KA61.14493209
51MAPK131.11843340
52RPS6KC11.11329818
53RPS6KL11.11329818
54CAMKK21.11033278
55ERBB41.06479878
56CHEK21.04737515
57BMX1.03508450
58MAPKAPK51.03507328
59NTRK31.01831211
60PAK61.00098490
61PRKCG0.99299497
62STK380.98599169
63PIK3CA0.98358975
64PRKCH0.96879418
65RET0.95748268
66CASK0.95718816
67PAK20.92413989
68MAPK70.91699163
69MAP3K30.91681188
70IRAK10.91018294
71WNK30.87032963
72NEK60.86030630
73MET0.85781572
74FGFR40.82013459
75ERBB30.80983171
76KSR20.80635886
77TTN0.79750583
78PIK3CG0.77125456
79LMTK20.76883206
80PRKCZ0.75410436
81ERBB20.74919632
82ROCK10.74276187
83CDC70.73952648
84NEK90.73670011
85EPHB20.73401287
86STK38L0.72947712
87PRKCE0.72698606
88WNK10.72097805
89PDGFRB0.70765401
90EPHA20.69917606
91MARK10.69630824
92PHKG20.68525544
93PHKG10.68525544
94CDK60.68050501
95MAP3K90.67757318
96IRAK30.67613599
97NEK10.67139362
98CAMK2G0.66702848
99TTK0.65817806
100ACVR1B0.65069406
101LRRK20.64777108
102BMPR1B0.64293339
103DYRK1B0.64014078
104CSNK1G20.63138057
105EPHA40.62865623
106MAP2K20.62464138
107ADRBK10.61563815
108PTK2B0.60754373
109SGK4940.60518778
110SGK2230.60518778
111RPS6KA20.59395869
112MAP2K70.58864862
113GSK3A0.58426806
114OXSR10.57887751
115SCYL20.57035653
116GRK50.55356581
117CAMK2D0.54365027
118RPS6KB20.54291784
119MAP4K20.52265012
120TNK20.51965298
121IGF1R0.51401176
122BCR0.50639034
123PDK20.50389842
124PDPK10.50261860
125PLK20.49541833
126MTOR0.48626412
127ABL20.48002873
128STK390.46614216
129LIMK10.46440777
130FGFR10.46203939
131SGK20.46199181
132CAMK2A0.41041011
133CDK90.35793838
134CSNK1G30.35503178
135ADRBK20.32636871
136CSNK1G10.31383106
137CDK50.27492583
138PASK0.26329883
139EGFR0.23559946
140PRKACA0.23175359
141PRKACG0.22271008
142DYRK30.21563083
143YES10.21239669
144CSNK1A1L0.21100254
145PRKAA10.20302146
146OBSCN0.20207183
147STK40.20028346
148PRKCA0.18021386
149SRPK10.16869368
150RPS6KB10.16638676
151PRKG10.15450730
152PRKAA20.15343634
153SGK10.14478136
154MELK0.12900278
155MAPK90.12895715
156PRKCD0.12074121
157WEE10.09929563
158EIF2AK20.06379494

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.33046170
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.18710846
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75964880
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.66993210
5Phototransduction_Homo sapiens_hsa047442.43082543
6Circadian entrainment_Homo sapiens_hsa047132.27031175
7Arginine biosynthesis_Homo sapiens_hsa002202.24620078
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22751056
9Butanoate metabolism_Homo sapiens_hsa006502.09644621
10Tryptophan metabolism_Homo sapiens_hsa003802.06103674
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.01444059
12Fatty acid degradation_Homo sapiens_hsa000712.01432825
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97252893
14Propanoate metabolism_Homo sapiens_hsa006401.87459634
15Nicotine addiction_Homo sapiens_hsa050331.79396004
16Complement and coagulation cascades_Homo sapiens_hsa046101.79263951
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.78163529
18Bile secretion_Homo sapiens_hsa049761.75127274
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72472205
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.64110319
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63165519
22Fat digestion and absorption_Homo sapiens_hsa049751.58448302
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58413879
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56016457
25Long-term depression_Homo sapiens_hsa047301.52896228
26Vitamin B6 metabolism_Homo sapiens_hsa007501.51477183
27Sulfur metabolism_Homo sapiens_hsa009201.50992983
28Peroxisome_Homo sapiens_hsa041461.46041087
29Taste transduction_Homo sapiens_hsa047421.45412589
30Fatty acid metabolism_Homo sapiens_hsa012121.45290760
31PPAR signaling pathway_Homo sapiens_hsa033201.42182707
32Pancreatic secretion_Homo sapiens_hsa049721.41158372
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34197343
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31721299
35Amphetamine addiction_Homo sapiens_hsa050311.31014155
36Protein digestion and absorption_Homo sapiens_hsa049741.30439276
37Pyruvate metabolism_Homo sapiens_hsa006201.26907604
38Linoleic acid metabolism_Homo sapiens_hsa005911.24863528
39Chemical carcinogenesis_Homo sapiens_hsa052041.21388137
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21132176
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19240261
42beta-Alanine metabolism_Homo sapiens_hsa004101.18539088
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16804488
44Retinol metabolism_Homo sapiens_hsa008301.14629067
45Starch and sucrose metabolism_Homo sapiens_hsa005001.14384741
46Glycerolipid metabolism_Homo sapiens_hsa005611.09364579
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07846647
48Steroid biosynthesis_Homo sapiens_hsa001001.07461907
49Vitamin digestion and absorption_Homo sapiens_hsa049771.07185952
50Histidine metabolism_Homo sapiens_hsa003401.05616914
51Oxytocin signaling pathway_Homo sapiens_hsa049211.05519484
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.05185539
53One carbon pool by folate_Homo sapiens_hsa006701.04559970
54Phenylalanine metabolism_Homo sapiens_hsa003601.04535264
55Glutamatergic synapse_Homo sapiens_hsa047241.04315056
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01413966
57Renin secretion_Homo sapiens_hsa049240.99980412
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.99492608
59Calcium signaling pathway_Homo sapiens_hsa040200.96781194
60Morphine addiction_Homo sapiens_hsa050320.96272131
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95924014
62Olfactory transduction_Homo sapiens_hsa047400.94867584
63Tyrosine metabolism_Homo sapiens_hsa003500.93216806
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92685798
65Cardiac muscle contraction_Homo sapiens_hsa042600.90858590
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90076997
67TGF-beta signaling pathway_Homo sapiens_hsa043500.88406108
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.87064120
69Selenocompound metabolism_Homo sapiens_hsa004500.83865820
70Arginine and proline metabolism_Homo sapiens_hsa003300.83804471
71N-Glycan biosynthesis_Homo sapiens_hsa005100.83403047
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81863088
73Ovarian steroidogenesis_Homo sapiens_hsa049130.80851971
74Carbon metabolism_Homo sapiens_hsa012000.79866478
75Insulin secretion_Homo sapiens_hsa049110.79455762
76Biosynthesis of amino acids_Homo sapiens_hsa012300.77660971
77Lysine degradation_Homo sapiens_hsa003100.77518961
78Folate biosynthesis_Homo sapiens_hsa007900.76696507
79Serotonergic synapse_Homo sapiens_hsa047260.75561797
80Thyroid hormone synthesis_Homo sapiens_hsa049180.74275340
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72814720
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72412892
83Synaptic vesicle cycle_Homo sapiens_hsa047210.70725609
84cAMP signaling pathway_Homo sapiens_hsa040240.69785438
85Dilated cardiomyopathy_Homo sapiens_hsa054140.68534976
86Hippo signaling pathway_Homo sapiens_hsa043900.67893598
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67052841
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65916563
89ABC transporters_Homo sapiens_hsa020100.65566580
90Prion diseases_Homo sapiens_hsa050200.63529323
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.63376322
92Caffeine metabolism_Homo sapiens_hsa002320.62803462
93GABAergic synapse_Homo sapiens_hsa047270.61101290
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.58798059
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57782760
96Collecting duct acid secretion_Homo sapiens_hsa049660.56208592
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54693054
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53679173
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51964787
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51700010
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51379535
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50881579
103Dorso-ventral axis formation_Homo sapiens_hsa043200.49341426
104Alzheimers disease_Homo sapiens_hsa050100.48148666
105Glucagon signaling pathway_Homo sapiens_hsa049220.47801265
106Basal cell carcinoma_Homo sapiens_hsa052170.47579817
107Fatty acid elongation_Homo sapiens_hsa000620.47009959
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45665728
109Glutathione metabolism_Homo sapiens_hsa004800.45470946
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.45035064
111Hedgehog signaling pathway_Homo sapiens_hsa043400.44927928
112Long-term potentiation_Homo sapiens_hsa047200.43317480
113Gastric acid secretion_Homo sapiens_hsa049710.41343506
114Insulin resistance_Homo sapiens_hsa049310.40260919
115Vibrio cholerae infection_Homo sapiens_hsa051100.39862745
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39224058
117Pyrimidine metabolism_Homo sapiens_hsa002400.38550974
118Fatty acid biosynthesis_Homo sapiens_hsa000610.38072574
119Staphylococcus aureus infection_Homo sapiens_hsa051500.37049925
120Alcoholism_Homo sapiens_hsa050340.36999761
121Cocaine addiction_Homo sapiens_hsa050300.34504931
122Circadian rhythm_Homo sapiens_hsa047100.33348588
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.30776926
124Sulfur relay system_Homo sapiens_hsa041220.30246751
125ECM-receptor interaction_Homo sapiens_hsa045120.29540138
126AMPK signaling pathway_Homo sapiens_hsa041520.29536813
127Dopaminergic synapse_Homo sapiens_hsa047280.29357475
128Cholinergic synapse_Homo sapiens_hsa047250.28578773
129Bladder cancer_Homo sapiens_hsa052190.27531906
130Mineral absorption_Homo sapiens_hsa049780.26457641
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25702267
132Lysosome_Homo sapiens_hsa041420.22475568
133Melanogenesis_Homo sapiens_hsa049160.22384833
134Gap junction_Homo sapiens_hsa045400.20579378
135Metabolic pathways_Homo sapiens_hsa011000.20502793
136Salivary secretion_Homo sapiens_hsa049700.19671171
137Focal adhesion_Homo sapiens_hsa045100.19354593
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19351944
139Insulin signaling pathway_Homo sapiens_hsa049100.18756341
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17960504

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