FAM134B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.92570124
2regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.87736133
3membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.87494169
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.82144791
5L-phenylalanine catabolic process (GO:0006559)4.82144791
6cardiac muscle contraction (GO:0060048)4.74883673
7myofibril assembly (GO:0030239)4.66490331
8cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.50182576
9cardiac myofibril assembly (GO:0055003)4.42877168
10striated muscle contraction (GO:0006941)4.41452892
11L-phenylalanine metabolic process (GO:0006558)4.36561799
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.36561799
13creatine metabolic process (GO:0006600)4.35719253
14regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.24119033
15detection of calcium ion (GO:0005513)4.05134342
16positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.84921726
17positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.77459552
18cell communication by electrical coupling (GO:0010644)3.75877461
19cardiac muscle hypertrophy (GO:0003300)3.73572352
20cell communication involved in cardiac conduction (GO:0086065)3.72451708
21aromatic amino acid family catabolic process (GO:0009074)3.70028842
22striated muscle hypertrophy (GO:0014897)3.68486419
23actin filament-based movement (GO:0030048)3.60672349
24regulation of membrane repolarization (GO:0060306)3.60517331
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.60284263
26aspartate family amino acid catabolic process (GO:0009068)3.58073547
27regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.54933850
28cellular potassium ion homeostasis (GO:0030007)3.51810823
29regulation of cardiac muscle cell contraction (GO:0086004)3.51509564
30actomyosin structure organization (GO:0031032)3.48590852
31relaxation of cardiac muscle (GO:0055119)3.45586650
32regulation of striated muscle contraction (GO:0006942)3.44952101
33regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.44190854
34valine metabolic process (GO:0006573)3.40090870
35carnitine shuttle (GO:0006853)3.36563520
36fatty acid elongation (GO:0030497)3.35914383
37cerebellar granule cell differentiation (GO:0021707)3.31402039
38branched-chain amino acid catabolic process (GO:0009083)3.29538629
39fatty acid transmembrane transport (GO:1902001)3.29371034
40lysine catabolic process (GO:0006554)3.28874857
41lysine metabolic process (GO:0006553)3.28874857
42short-chain fatty acid metabolic process (GO:0046459)3.28857861
43muscle hypertrophy (GO:0014896)3.24973596
44ventricular cardiac muscle cell action potential (GO:0086005)3.24353671
45regulation of calcium ion transmembrane transporter activity (GO:1901019)3.22893142
46regulation of calcium ion transmembrane transport (GO:1903169)3.22893142
47axon ensheathment in central nervous system (GO:0032291)3.22656564
48central nervous system myelination (GO:0022010)3.22656564
49negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.22472714
50sodium ion export (GO:0071436)3.20826337
51cysteine metabolic process (GO:0006534)3.20535968
52response to inactivity (GO:0014854)3.20083942
53branched-chain amino acid metabolic process (GO:0009081)3.16101456
54sarcoplasmic reticulum calcium ion transport (GO:0070296)3.13256701
55coenzyme catabolic process (GO:0009109)3.12493185
56fatty acid catabolic process (GO:0009062)3.10555983
57fatty acid beta-oxidation (GO:0006635)3.10155344
58regulation of relaxation of muscle (GO:1901077)3.07179605
59NADH metabolic process (GO:0006734)3.07123954
60acetyl-CoA metabolic process (GO:0006084)3.06981037
61muscle contraction (GO:0006936)3.06180168
62response to mercury ion (GO:0046689)3.05076700
63glyoxylate metabolic process (GO:0046487)3.04527404
64carnitine transmembrane transport (GO:1902603)3.04135179
65carnitine transport (GO:0015879)3.02125447
66amino-acid betaine transport (GO:0015838)3.02125447
67actin-myosin filament sliding (GO:0033275)3.01751544
68muscle filament sliding (GO:0030049)3.01751544
69cellular ketone body metabolic process (GO:0046950)2.99677875
70relaxation of muscle (GO:0090075)2.97047673
71cardiac muscle tissue morphogenesis (GO:0055008)2.96752421
72regulation of cell communication by electrical coupling (GO:0010649)2.96658067
73drug transmembrane transport (GO:0006855)2.95493567
74fatty acid oxidation (GO:0019395)2.95189241
75cellular sodium ion homeostasis (GO:0006883)2.91768739
762-oxoglutarate metabolic process (GO:0006103)2.88931488
77positive regulation of synapse maturation (GO:0090129)2.88742098
78lipid oxidation (GO:0034440)2.88488239
79cardiac conduction (GO:0061337)2.88245794
80synaptic vesicle exocytosis (GO:0016079)2.87807849
81positive regulation of cation channel activity (GO:2001259)2.87305268
82monocarboxylic acid catabolic process (GO:0072329)2.86600315
83response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.86212048
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.85896253
85regulation of heart rate (GO:0002027)2.84763334
86positive regulation of potassium ion transmembrane transport (GO:1901381)2.84753345
87regulation of triglyceride catabolic process (GO:0010896)2.82881933
88cardiac muscle cell action potential (GO:0086001)2.82734317
89kynurenine metabolic process (GO:0070189)2.82713825
90sarcomere organization (GO:0045214)2.82404375
91negative regulation of leukocyte chemotaxis (GO:0002689)2.82266018
92positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.81698517
93intestinal cholesterol absorption (GO:0030299)2.81308955
94regulation of skeletal muscle contraction (GO:0014819)2.79760800
95muscle system process (GO:0003012)2.79496244
96response to epinephrine (GO:0071871)2.78612475
97potassium ion import (GO:0010107)2.78570753
98quaternary ammonium group transport (GO:0015697)2.78570266
99regulation of the force of heart contraction (GO:0002026)2.77687094
100indolalkylamine catabolic process (GO:0046218)2.77468849
101tryptophan catabolic process (GO:0006569)2.77468849
102indole-containing compound catabolic process (GO:0042436)2.77468849
103bile acid biosynthetic process (GO:0006699)2.77230313
104regulation of cardiac muscle contraction (GO:0055117)2.76414301
105muscle tissue morphogenesis (GO:0060415)2.75791291
106positive regulation of sodium ion transport (GO:0010765)2.73848114
107regulation of sodium ion transmembrane transport (GO:1902305)2.73152305
108negative regulation of calcium ion transmembrane transport (GO:1903170)2.73141227
109negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.73141227
110neuronal action potential propagation (GO:0019227)2.72891919
111positive regulation of potassium ion transport (GO:0043268)2.72427215
112cardiac muscle cell action potential involved in contraction (GO:0086002)2.72390239
113cellular response to epinephrine stimulus (GO:0071872)2.72271794
114striated muscle adaptation (GO:0014888)2.71067394
115amino-acid betaine metabolic process (GO:0006577)2.70492485
116cellular glucuronidation (GO:0052695)2.70031767
117regulation of potassium ion transmembrane transporter activity (GO:1901016)2.67289238
118very long-chain fatty acid metabolic process (GO:0000038)2.66285211
119ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.65859686
120alpha-linolenic acid metabolic process (GO:0036109)2.65587135
121membrane depolarization during action potential (GO:0086010)2.65524241
122acyl-CoA biosynthetic process (GO:0071616)2.65388569
123thioester biosynthetic process (GO:0035384)2.65388569
124negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.65208226
125skeletal muscle contraction (GO:0003009)2.62717467
126glucuronate metabolic process (GO:0019585)2.62395556
127uronic acid metabolic process (GO:0006063)2.62395556
128cardiac muscle hypertrophy in response to stress (GO:0014898)2.61899915
129muscle hypertrophy in response to stress (GO:0003299)2.61899915
130cardiac muscle adaptation (GO:0014887)2.61899915
131mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61666896
132regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.60733580
133carnitine metabolic process (GO:0009437)2.60676453
134tryptophan metabolic process (GO:0006568)2.60189186
135regulation of actin filament-based movement (GO:1903115)2.59767840
136ketone body metabolic process (GO:1902224)2.58867854
137alpha-amino acid catabolic process (GO:1901606)2.58699496
138acyl-CoA metabolic process (GO:0006637)2.58598598
139thioester metabolic process (GO:0035383)2.58598598
140regulation of voltage-gated calcium channel activity (GO:1901385)2.58598221
141regulation of sodium ion transmembrane transporter activity (GO:2000649)2.56581722
142heart contraction (GO:0060047)2.55593700
143heart process (GO:0003015)2.55593700
144actin-mediated cell contraction (GO:0070252)2.55413609
145regulation of heart contraction (GO:0008016)2.55194804
146regulation of cation channel activity (GO:2001257)2.54148858
147macroautophagy (GO:0016236)2.53549417
148cofactor catabolic process (GO:0051187)2.53512633
149aromatic amino acid family metabolic process (GO:0009072)2.52297638
150carboxylic acid catabolic process (GO:0046395)2.51473764
151organic acid catabolic process (GO:0016054)2.51473764
152bundle of His cell to Purkinje myocyte communication (GO:0086069)2.50633192
153regulation of sequestering of triglyceride (GO:0010889)2.50418310
154ethanol oxidation (GO:0006069)2.49840492
155cellular amino acid catabolic process (GO:0009063)2.49610291
156regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.46743641
157positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.46190827
158cellular modified amino acid catabolic process (GO:0042219)2.44078132
159succinate metabolic process (GO:0006105)2.43881997
160sulfur amino acid catabolic process (GO:0000098)2.42848726
161glutamate metabolic process (GO:0006536)2.39942483
162dicarboxylic acid catabolic process (GO:0043649)2.39810438
163myelin maintenance (GO:0043217)2.39430348
164regulation of cholesterol metabolic process (GO:0090181)2.38777691
165fatty-acyl-CoA metabolic process (GO:0035337)2.37756385
166tricarboxylic acid cycle (GO:0006099)2.35467177
167skeletal muscle adaptation (GO:0043501)2.34993040
168tyrosine metabolic process (GO:0006570)2.34013814
169positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.33437718
170fatty-acyl-CoA biosynthetic process (GO:0046949)2.32526430
171triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.31390654
172regulation of acyl-CoA biosynthetic process (GO:0050812)2.30824564
173negative regulation of potassium ion transmembrane transport (GO:1901380)2.30372426
174alkaloid metabolic process (GO:0009820)2.30355795
175negative regulation of protein localization to cell surface (GO:2000009)2.29273300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.30328050
2EZH2_22144423_ChIP-Seq_EOC_Human3.82509385
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.09344842
4* LXR_22158963_ChIP-Seq_LIVER_Mouse2.75216397
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.58644612
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.49551125
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.38982001
8* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.38708366
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08608121
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98273677
11IRF8_22096565_ChIP-ChIP_GC-B_Human1.97132112
12CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92156511
13DROSHA_22980978_ChIP-Seq_HELA_Human1.89465434
14TAF15_26573619_Chip-Seq_HEK293_Human1.84169776
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72909046
16GATA1_22025678_ChIP-Seq_K562_Human1.71905033
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71331066
18* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70821357
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69897447
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.69558254
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.68952732
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67329285
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67329285
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.64785646
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62325526
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.61153194
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61133733
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59700248
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53352142
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.51481942
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51419630
32REST_21632747_ChIP-Seq_MESCs_Mouse1.49997776
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.44803010
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.44376998
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44018859
36RUNX_20019798_ChIP-Seq_JUKART_Human1.43514353
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41064059
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39725411
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39556777
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38227339
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36335434
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.35954177
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.34400248
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33779332
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33779332
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.32981248
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.32104466
48* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26083673
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23239150
50EGR1_19032775_ChIP-ChIP_M12_Human1.22613931
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22452016
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21511162
53GBX2_23144817_ChIP-Seq_PC3_Human1.20016116
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19544531
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.18849579
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17259238
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16358232
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.16139001
59SCL_19346495_ChIP-Seq_HPC-7_Human1.16092070
60* TBX20_22080862_ChIP-Seq_HEART_Mouse1.15615787
61* TBX20_22328084_ChIP-Seq_HEART_Mouse1.15615787
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14827710
63* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14748030
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.13476645
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12973464
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.12661618
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11738209
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11049706
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.10821372
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10795903
71TCF4_23295773_ChIP-Seq_U87_Human1.10650552
72* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10455898
73IGF1R_20145208_ChIP-Seq_DFB_Human1.09348114
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08698854
75SOX2_20726797_ChIP-Seq_SW620_Human1.08463007
76AR_21572438_ChIP-Seq_LNCaP_Human1.08460160
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.08067871
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07986584
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07521733
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.07071089
81HTT_18923047_ChIP-ChIP_STHdh_Human1.06352941
82* AR_25329375_ChIP-Seq_VCAP_Human1.05401524
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.04956976
84* STAT3_23295773_ChIP-Seq_U87_Human1.04539069
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04113790
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03997424
87* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03623472
88* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02704473
89SMAD4_21741376_ChIP-Seq_HESCs_Human1.02691816
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00833330
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00242391
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99035143
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98194965
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.97812589
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97569024
96CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97425873
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97068776
98TP53_16413492_ChIP-PET_HCT116_Human0.96979871
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96786202
100AR_19668381_ChIP-Seq_PC3_Human0.96561178
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96370577
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95521187
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95450013
104TRIM28_21343339_ChIP-Seq_HEK293_Human0.95296545
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94708547
106* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94045158
107GATA2_19941826_ChIP-Seq_K562_Human0.93559106
108ER_23166858_ChIP-Seq_MCF-7_Human0.92709266
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92494177
110MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91676288
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91470802
112RING1B_27294783_Chip-Seq_ESCs_Mouse0.91374585
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91186266
114* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90939233
115* CJUN_26792858_Chip-Seq_BT549_Human0.90126463
116* PIAS1_25552417_ChIP-Seq_VCAP_Human0.89799116
117CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89703124
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89473659
119AHR_22903824_ChIP-Seq_MCF-7_Human0.89284674
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89260807
121VDR_22108803_ChIP-Seq_LS180_Human0.88399325
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87983867
123TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87849506
124TP63_23658742_ChIP-Seq_EP156T_Human0.87192284
125* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86898863
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.86224051
127* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85510903
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85507495
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85373403
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85150011
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85068114
132VDR_24787735_ChIP-Seq_THP-1_Human0.84971920
133NANOG_19829295_ChIP-Seq_ESCs_Human0.84446575
134SOX2_19829295_ChIP-Seq_ESCs_Human0.84446575
135P300_19829295_ChIP-Seq_ESCs_Human0.84090004
136MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83670432
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83292107
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.83139768
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81986757
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81909446
141WT1_19549856_ChIP-ChIP_CCG9911_Human0.81804113
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81559431
143BCAT_22108803_ChIP-Seq_LS180_Human0.80216027
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79219264
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.79093341
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78971401
147ARNT_22903824_ChIP-Seq_MCF-7_Human0.78760309
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78430152
149GATA1_19941826_ChIP-Seq_K562_Human0.78326687
150GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77857772
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77810793
152FLI1_27457419_Chip-Seq_LIVER_Mouse0.77771977
153TP53_18474530_ChIP-ChIP_U2OS_Human0.76968842
154SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.76755522
155PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75844545
156EZH2_27294783_Chip-Seq_NPCs_Mouse0.74011177
157SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.73914906
158RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73658893
159GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.73331527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.84947481
2MP0005085_abnormal_gallbladder_physiolo3.65897167
3MP0005360_urolithiasis3.38479263
4MP0005365_abnormal_bile_salt3.31350290
5MP0005083_abnormal_biliary_tract3.12213528
6MP0008875_abnormal_xenobiotic_pharmacok2.86872711
7MP0002837_dystrophic_cardiac_calcinosis2.69919530
8MP0001666_abnormal_nutrient_absorption2.63049910
9MP0000751_myopathy2.50190260
10MP0003195_calcinosis2.48072246
11MP0000749_muscle_degeneration2.46445542
12MP0004859_abnormal_synaptic_plasticity2.46163290
13MP0003806_abnormal_nucleotide_metabolis2.43052442
14MP0003646_muscle_fatigue2.33733128
15MP0004036_abnormal_muscle_relaxation2.29552865
16MP0004130_abnormal_muscle_cell2.24723032
17MP0000920_abnormal_myelination2.11204490
18MP0005332_abnormal_amino_acid2.04315897
19MP0003879_abnormal_hair_cell1.97213874
20MP0003252_abnormal_bile_duct1.93721840
21MP0004084_abnormal_cardiac_muscle1.85724569
22MP0002272_abnormal_nervous_system1.81830254
23MP0002064_seizures1.80931891
24MP0002138_abnormal_hepatobiliary_system1.80578769
25MP0000747_muscle_weakness1.76806333
26MP0003635_abnormal_synaptic_transmissio1.74651907
27MP0009780_abnormal_chondrocyte_physiolo1.70075629
28MP0006138_congestive_heart_failure1.69842569
29MP0005670_abnormal_white_adipose1.68428606
30MP0009745_abnormal_behavioral_response1.64086888
31MP0005330_cardiomyopathy1.64028266
32MP0006036_abnormal_mitochondrial_physio1.61678433
33MP0009046_muscle_twitch1.59630850
34MP0008569_lethality_at_weaning1.58983476
35MP0005584_abnormal_enzyme/coenzyme_acti1.57089801
36MP0005451_abnormal_body_composition1.55384501
37MP0002118_abnormal_lipid_homeostasis1.53170523
38MP0004215_abnormal_myocardial_fiber1.52899977
39MP0001486_abnormal_startle_reflex1.49233897
40MP0001501_abnormal_sleep_pattern1.48878631
41MP0003191_abnormal_cellular_cholesterol1.47291086
42MP0001984_abnormal_olfaction1.45932253
43MP0001440_abnormal_grooming_behavior1.45114454
44MP0002106_abnormal_muscle_physiology1.45015913
45MP0005058_abnormal_lysosome_morphology1.44501975
46MP0004484_altered_response_of1.44329082
47MP0009840_abnormal_foam_cell1.44067430
48MP0004087_abnormal_muscle_fiber1.42170330
49MP0004145_abnormal_muscle_electrophysio1.39310575
50MP0002063_abnormal_learning/memory/cond1.37672515
51MP0004742_abnormal_vestibular_system1.36270333
52MP0003950_abnormal_plasma_membrane1.36227972
53MP0002972_abnormal_cardiac_muscle1.36225061
54MP0003656_abnormal_erythrocyte_physiolo1.35913024
55MP0005620_abnormal_muscle_contractility1.35719645
56MP0004885_abnormal_endolymph1.35545701
57MP0005423_abnormal_somatic_nervous1.34611724
58MP0002734_abnormal_mechanical_nocicepti1.34609843
59MP0003690_abnormal_glial_cell1.34443445
60MP0010329_abnormal_lipoprotein_level1.34434413
61MP0002127_abnormal_cardiovascular_syste1.27510369
62MP0002638_abnormal_pupillary_reflex1.25627380
63MP0002735_abnormal_chemical_nociception1.24809911
64MP0005386_behavior/neurological_phenoty1.24179190
65MP0004924_abnormal_behavior1.24179190
66MP0003868_abnormal_feces_composition1.20526977
67MP0002254_reproductive_system_inflammat1.20047961
68MP0005319_abnormal_enzyme/_coenzyme1.18739210
69MP0001835_abnormal_antigen_presentation1.17475664
70MP0003880_abnormal_central_pattern1.16943031
71MP0004510_myositis1.16207368
72MP0004043_abnormal_pH_regulation1.15485005
73MP0009643_abnormal_urine_homeostasis1.13862254
74MP0002572_abnormal_emotion/affect_behav1.12229592
75MP0005369_muscle_phenotype1.11282709
76MP0006082_CNS_inflammation1.09194160
77MP0000013_abnormal_adipose_tissue1.06740518
78MP0003221_abnormal_cardiomyocyte_apopto1.05734674
79MP0002067_abnormal_sensory_capabilities1.05519224
80MP0005165_increased_susceptibility_to1.02100840
81MP0004233_abnormal_muscle_weight1.01382322
82MP0002269_muscular_atrophy0.99155897
83MP0005535_abnormal_body_temperature0.98665674
84MP0000343_altered_response_to0.97218514
85MP0001544_abnormal_cardiovascular_syste0.97189865
86MP0005385_cardiovascular_system_phenoty0.97189865
87MP0000609_abnormal_liver_physiology0.96995761
88MP0000604_amyloidosis0.96347861
89MP0005084_abnormal_gallbladder_morpholo0.95685146
90MP0008775_abnormal_heart_ventricle0.93789831
91MP0009764_decreased_sensitivity_to0.93110629
92MP0005464_abnormal_platelet_physiology0.92149525
93MP0010678_abnormal_skin_adnexa0.91129201
94MP0008469_abnormal_protein_level0.90976680
95MP0005666_abnormal_adipose_tissue0.90483278
96MP0000685_abnormal_immune_system0.90386519
97MP0009785_altered_susceptibility_to0.90184568
98MP0003724_increased_susceptibility_to0.90056140
99MP0004147_increased_porphyrin_level0.89826192
100MP0010630_abnormal_cardiac_muscle0.89442053
101MP0000383_abnormal_hair_follicle0.89334446
102MP0000759_abnormal_skeletal_muscle0.88650262
103MP0001502_abnormal_circadian_rhythm0.88436013
104MP0003137_abnormal_impulse_conducting0.88109890
105MP0002148_abnormal_hypersensitivity_rea0.87689211
106MP0002332_abnormal_exercise_endurance0.85925265
107MP0002066_abnormal_motor_capabilities/c0.85421108
108MP0001485_abnormal_pinna_reflex0.85213458
109MP0005387_immune_system_phenotype0.84913298
110MP0001790_abnormal_immune_system0.84913298
111MP0008874_decreased_physiological_sensi0.84907322
112MP0002822_catalepsy0.84647662
113MP0001765_abnormal_ion_homeostasis0.84177040
114MP0005646_abnormal_pituitary_gland0.83783342
115MP0004270_analgesia0.83653827
116MP0002108_abnormal_muscle_morphology0.83500483
117MP0001764_abnormal_homeostasis0.82610971
118MP0002419_abnormal_innate_immunity0.82208841
119MP0003329_amyloid_beta_deposits0.81884776
120MP0009765_abnormal_xenobiotic_induced0.80617811
121MP0000230_abnormal_systemic_arterial0.80392176
122MP0005375_adipose_tissue_phenotype0.80343983
123MP0001873_stomach_inflammation0.79525327
124MP0000003_abnormal_adipose_tissue0.79327728
125MP0004019_abnormal_vitamin_homeostasis0.78215262
126MP0003186_abnormal_redox_activity0.78140057
127MP0002229_neurodegeneration0.77641591
128MP0003631_nervous_system_phenotype0.77464121
129MP0003436_decreased_susceptibility_to0.76347447
130MP0001970_abnormal_pain_threshold0.75485974
131MP0002876_abnormal_thyroid_physiology0.74331629
132MP0004381_abnormal_hair_follicle0.73683375
133MP0003300_gastrointestinal_ulcer0.73451071
134MP0005636_abnormal_mineral_homeostasis0.72967204
135MP0005025_abnormal_response_to0.72684162
136MP0005551_abnormal_eye_electrophysiolog0.72108836
137MP0002078_abnormal_glucose_homeostasis0.71729743
138MP0004142_abnormal_muscle_tone0.71712918
139MP0003045_fibrosis0.71555964
140MP0003633_abnormal_nervous_system0.71297233
141MP0009763_increased_sensitivity_to0.70134210
142MP0004085_abnormal_heartbeat0.69383065
143MP0002971_abnormal_brown_adipose0.68219775
144MP0000750_abnormal_muscle_regeneration0.67256355
145MP0001968_abnormal_touch/_nociception0.67029416
146MP0003638_abnormal_response/metabolism_0.66395338
147MP0002909_abnormal_adrenal_gland0.66048729
148MP0003634_abnormal_glial_cell0.63748700
149MP0001299_abnormal_eye_distance/0.63082626
150MP0000778_abnormal_nervous_system0.62621137
151MP0002882_abnormal_neuron_morphology0.61784756
152MP0003011_delayed_dark_adaptation0.61774031

Predicted human phenotypes

RankGene SetZ-score
1Bundle branch block (HP:0011710)5.82679729
2Exercise-induced myalgia (HP:0003738)4.23420091
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.01917220
4Heart block (HP:0012722)3.88349120
5Exercise-induced muscle cramps (HP:0003710)3.83218130
6Muscle hypertrophy of the lower extremities (HP:0008968)3.80375105
7Calf muscle hypertrophy (HP:0008981)3.68527837
8Hyporeflexia of lower limbs (HP:0002600)3.63290485
9Abnormal atrioventricular conduction (HP:0005150)3.55315395
10Muscle fiber inclusion bodies (HP:0100299)3.51474846
11Muscle fiber splitting (HP:0003555)3.49222042
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.41802995
13Frequent falls (HP:0002359)3.38382243
14Ventricular fibrillation (HP:0001663)3.36586904
15Ventricular arrhythmia (HP:0004308)3.22665867
16Sudden death (HP:0001699)3.20757345
17Centrally nucleated skeletal muscle fibers (HP:0003687)3.16797527
18Myoglobinuria (HP:0002913)3.14307921
19Nemaline bodies (HP:0003798)3.12150877
20Action tremor (HP:0002345)3.11183032
21Axonal loss (HP:0003447)3.07810532
22Focal motor seizures (HP:0011153)3.06248938
23Atrioventricular block (HP:0001678)3.02868280
24EMG: neuropathic changes (HP:0003445)3.01501121
25Intrahepatic cholestasis (HP:0001406)2.98494497
26Abnormality of fatty-acid metabolism (HP:0004359)2.98240395
27Rimmed vacuoles (HP:0003805)2.93308245
28Ketosis (HP:0001946)2.89764616
29Febrile seizures (HP:0002373)2.84682112
30Hyperlipoproteinemia (HP:0010980)2.80016380
31Palpitations (HP:0001962)2.78516647
32EMG: myopathic abnormalities (HP:0003458)2.77712821
33Right ventricular cardiomyopathy (HP:0011663)2.74711518
34Xanthomatosis (HP:0000991)2.71997498
35Distal lower limb muscle weakness (HP:0009053)2.71493352
36Myopathic facies (HP:0002058)2.69914194
37Ventricular tachycardia (HP:0004756)2.69301712
38Hyperammonemia (HP:0001987)2.68555425
39Hyperkalemia (HP:0002153)2.64559251
40Abnormality of the calf musculature (HP:0001430)2.62303503
41Cerebral edema (HP:0002181)2.59376170
42Myokymia (HP:0002411)2.59174307
43Abnormality of skeletal muscle fiber size (HP:0012084)2.51953754
44Gout (HP:0001997)2.51876323
45Abnormality of the foot musculature (HP:0001436)2.50691168
46Deep venous thrombosis (HP:0002625)2.46374813
47Round ear (HP:0100830)2.45323750
48Increased variability in muscle fiber diameter (HP:0003557)2.44309483
49Fetal akinesia sequence (HP:0001989)2.44256701
50Ketoacidosis (HP:0001993)2.43936236
51Abnormal EKG (HP:0003115)2.43929224
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.41132562
53Generalized aminoaciduria (HP:0002909)2.39305303
54Atonic seizures (HP:0010819)2.37059926
55Asymmetric septal hypertrophy (HP:0001670)2.36680708
56Acute encephalopathy (HP:0006846)2.35652061
57Distal arthrogryposis (HP:0005684)2.35489653
58Focal seizures (HP:0007359)2.34623273
59Muscle stiffness (HP:0003552)2.32122849
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31450479
61Dicarboxylic aciduria (HP:0003215)2.31450479
62Areflexia of lower limbs (HP:0002522)2.31443518
63Difficulty running (HP:0009046)2.30614251
64Rhabdomyolysis (HP:0003201)2.28839636
65Atrial fibrillation (HP:0005110)2.26649599
66Left ventricular hypertrophy (HP:0001712)2.25363233
67Fat malabsorption (HP:0002630)2.21409698
68Abnormality of serine family amino acid metabolism (HP:0010894)2.21257541
69Abnormality of glycine metabolism (HP:0010895)2.21257541
70Dysmetric saccades (HP:0000641)2.20286412
71Primary atrial arrhythmia (HP:0001692)2.20186025
72Syncope (HP:0001279)2.18844822
73Abnormality of methionine metabolism (HP:0010901)2.18821927
74Generalized muscle weakness (HP:0003324)2.18091018
75Cerebral hemorrhage (HP:0001342)2.18029981
76Increased connective tissue (HP:0009025)2.17245451
77Steatorrhea (HP:0002570)2.16932499
78Abnormality of purine metabolism (HP:0004352)2.16801935
79Metabolic acidosis (HP:0001942)2.15005555
80Acute necrotizing encephalopathy (HP:0006965)2.14450366
81Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13429787
82Myotonia (HP:0002486)2.12359848
83Hypoglycemic coma (HP:0001325)2.12149031
84Prolonged partial thromboplastin time (HP:0003645)2.11386619
85Dysdiadochokinesis (HP:0002075)2.11124048
86Dilated cardiomyopathy (HP:0001644)2.10933563
87Hyperventilation (HP:0002883)2.10258110
88Neurofibrillary tangles (HP:0002185)2.07118299
89Increased purine levels (HP:0004368)2.04846169
90Hyperuricemia (HP:0002149)2.04846169
91Supraventricular tachycardia (HP:0004755)2.04518273
92Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03838083
93Abnormal mitochondria in muscle tissue (HP:0008316)2.02221783
94Hepatic necrosis (HP:0002605)2.00991537
95Lipoatrophy (HP:0100578)1.99730780
96Complement deficiency (HP:0004431)1.99258868
97Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98445589
98Absent phalangeal crease (HP:0006109)1.96816972
99Supraventricular arrhythmia (HP:0005115)1.96112836
100Hyperglycinuria (HP:0003108)1.94742362
101Hypoalphalipoproteinemia (HP:0003233)1.94693130
102Lethargy (HP:0001254)1.94384128
103Insulin-resistant diabetes mellitus (HP:0000831)1.93993936
104Absence seizures (HP:0002121)1.93319397
105Vascular calcification (HP:0004934)1.92741793
106Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.91723374
107Subaortic stenosis (HP:0001682)1.91430523
108Abnormality of the left ventricular outflow tract (HP:0011103)1.91430523
109Hypothermia (HP:0002045)1.91212022
110Mildly elevated creatine phosphokinase (HP:0008180)1.91206044
111Ankle clonus (HP:0011448)1.91133789
112Type 1 muscle fiber predominance (HP:0003803)1.90137488
113Gowers sign (HP:0003391)1.90025506
114Neck muscle weakness (HP:0000467)1.88684112
115Intention tremor (HP:0002080)1.88452241
116Foot dorsiflexor weakness (HP:0009027)1.88227813
117Progressive macrocephaly (HP:0004481)1.88053235
118Ulnar deviation of the wrist (HP:0003049)1.87528741
119Increased muscle lipid content (HP:0009058)1.85927370
120Bulbar palsy (HP:0001283)1.85665501
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85150073
122Amyloidosis (HP:0011034)1.84702594
123Stridor (HP:0010307)1.83250979
124Vomiting (HP:0002013)1.82014491
125Abnormality of sulfur amino acid metabolism (HP:0004339)1.81935838
126Amblyopia (HP:0000646)1.81896353
127Broad-based gait (HP:0002136)1.81359561
128Abnormality of urine glucose concentration (HP:0011016)1.81155089
129Glycosuria (HP:0003076)1.81155089
130Scapular winging (HP:0003691)1.80713182
131Onion bulb formation (HP:0003383)1.80671474
132Prolonged QT interval (HP:0001657)1.80612820
133Increased serum pyruvate (HP:0003542)1.80146803
134Abnormality of glycolysis (HP:0004366)1.80146803
135Generalized tonic-clonic seizures (HP:0002069)1.79518672
136Proximal tubulopathy (HP:0000114)1.78910093
137Cholelithiasis (HP:0001081)1.78528995
138Abnormal gallbladder morphology (HP:0012437)1.77835789
139Hyperglycinemia (HP:0002154)1.77757797
140Sudden cardiac death (HP:0001645)1.76800840
141Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76664931
142Degeneration of the lateral corticospinal tracts (HP:0002314)1.76664931
143Nonprogressive disorder (HP:0003680)1.76552299
144Hypobetalipoproteinemia (HP:0003563)1.76260324
145Hypolipoproteinemia (HP:0010981)1.75906946
146Epileptic encephalopathy (HP:0200134)1.74888542
147Mitochondrial inheritance (HP:0001427)1.74082104
148Muscular dystrophy (HP:0003560)1.74052106
149Steppage gait (HP:0003376)1.73854177
150Postural instability (HP:0002172)1.70780991
151Proximal amyotrophy (HP:0007126)1.70517459
152Hyperglycemia (HP:0003074)1.68509429
153Difficulty climbing stairs (HP:0003551)1.66699423
154Abnormal finger flexion creases (HP:0006143)1.64036580
155Hyperinsulinemic hypoglycemia (HP:0000825)1.62435295
156Dialeptic seizures (HP:0011146)1.60019813
157Limb dystonia (HP:0002451)1.59690223
158Pheochromocytoma (HP:0002666)1.58486680
159Hip contracture (HP:0003273)1.56355585
160Progressive cerebellar ataxia (HP:0002073)1.55480673
161Abnormality of potassium homeostasis (HP:0011042)1.55458702
162Ragged-red muscle fibers (HP:0003200)1.54157543
163Scanning speech (HP:0002168)1.52807858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.81113098
2BCKDK3.31403462
3OBSCN3.14446081
4BRSK22.92367418
5MARK12.87423076
6RIPK12.66867272
7EPHB12.56257521
8WNK42.45148069
9OXSR12.42051071
10PHKG12.40585178
11PHKG22.40585178
12CASK2.33537822
13TTN2.32875142
14MAP2K32.12720804
15NTRK21.90314888
16MUSK1.89819495
17TGFBR21.88158013
18GRK71.86340694
19UHMK11.85526675
20NTRK31.76361186
21PIK3CG1.75526090
22MAP4K11.72144505
23MAPKAPK51.69820700
24MAP3K141.69414544
25PIK3CA1.63510008
26MST41.57219699
27PINK11.50048236
28MYLK1.44995949
29MAP2K41.43977879
30TRPM71.43234858
31PDK21.38176938
32STK241.36899715
33MAP2K61.33213044
34PKN11.31477461
35WNK11.31087850
36MAP3K61.30272683
37MAP3K31.26618841
38MAP3K71.24454364
39PDK41.21874649
40PDK31.21874649
41EPHA41.21836235
42CAMKK21.18151891
43SGK21.16800960
44MAPK121.15123839
45CSF1R1.14798131
46EPHA31.10672548
47DAPK21.10189254
48BRSK11.05442461
49WEE11.05316210
50PAK61.04925347
51TBK11.02762163
52KIT1.01825147
53ZAP701.01341321
54NME10.99129854
55TNIK0.99052539
56MAPK150.98302908
57PRKCQ0.97071143
58BLK0.96971130
59CAMK2D0.96622994
60IKBKE0.94073171
61MAP3K90.93796685
62MAP3K130.93794820
63CAMK10.89782992
64FGFR40.88276486
65TXK0.87531326
66PRKAA10.85929439
67CAMKK10.85924457
68CDK50.85097301
69DMPK0.84842463
70LMTK20.84384472
71CAMK2G0.82984710
72SGK30.81841953
73TIE10.81599763
74PRKG10.79755497
75ITK0.78438709
76ACVR1B0.77249835
77STK110.77102084
78ERN10.77047249
79SGK2230.75460925
80SGK4940.75460925
81FGFR20.75429061
82MAPK70.74738701
83CAMK40.74342488
84INSRR0.73168327
85TYK20.73018206
86MAPK130.70564677
87PDK10.68390222
88SGK10.67855735
89BTK0.66485095
90PRKD10.63438565
91IKBKB0.63163828
92PKN20.61739348
93JAK10.61476563
94ROCK10.61309063
95BMPR1B0.60012150
96FRK0.59953479
97CAMK2B0.59763652
98TEC0.59309188
99PDPK10.58552749
100PRKAA20.58483361
101RET0.57758460
102MAPK40.56469509
103ARAF0.55432130
104MATK0.55031026
105PRKD30.54556205
106NEK90.54171339
107SYK0.52504235
108LATS20.52335400
109ROCK20.52265807
110NEK60.51768530
111TAOK10.51702847
112MAP2K20.50943340
113MAP2K70.50767900
114PNCK0.50570146
115PRKACA0.50461710
116MET0.49841405
117MST1R0.49613201
118PAK30.49443456
119FGR0.48648846
120JAK20.48247166
121RPS6KA30.48186082
122MARK20.48035600
123MAPK100.47981338
124BCR0.47635756
125CSNK1G30.47607408
126LCK0.47599957
127CAMK2A0.47247432
128PRKACB0.47160756
129MAP3K10.47051421
130FLT30.46610464
131HIPK20.46427352
132IRAK40.46273214
133PRKCE0.45799319
134MAP3K120.44384561
135PRKCG0.44323115
136BMPR20.43697487
137CSNK1A1L0.43542234
138STK380.43074606
139FER0.43070269
140AKT30.42730110
141MAP3K20.41053028
142MAP3K50.40238332
143KSR20.40133998
144MAPKAPK30.39949039
145CSNK1G10.39880192
146PRKCH0.38877037
147SIK10.37957620
148GRK50.37292611
149NLK0.36729935
150MAP2K10.35585917
151PRKACG0.34363356
152MAP3K100.33747443
153DYRK1A0.32430825
154FGFR30.32026824
155PRKCA0.29859753

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06803642
2Propanoate metabolism_Homo sapiens_hsa006402.90306705
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.75543550
4Fatty acid elongation_Homo sapiens_hsa000622.56729838
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44524733
6Fatty acid degradation_Homo sapiens_hsa000712.36251831
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.28086800
8Histidine metabolism_Homo sapiens_hsa003402.26049277
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14537072
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.02889431
11Butanoate metabolism_Homo sapiens_hsa006501.93015577
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91432571
13Circadian rhythm_Homo sapiens_hsa047101.89315990
14Tryptophan metabolism_Homo sapiens_hsa003801.87509616
15Sulfur metabolism_Homo sapiens_hsa009201.82916915
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78934860
17Pyruvate metabolism_Homo sapiens_hsa006201.77433678
18Fatty acid metabolism_Homo sapiens_hsa012121.77400795
19Insulin secretion_Homo sapiens_hsa049111.77383016
20Peroxisome_Homo sapiens_hsa041461.77333693
21Renin secretion_Homo sapiens_hsa049241.75925258
22Arginine biosynthesis_Homo sapiens_hsa002201.75590106
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75363622
24Circadian entrainment_Homo sapiens_hsa047131.73223947
25Steroid biosynthesis_Homo sapiens_hsa001001.70807306
26beta-Alanine metabolism_Homo sapiens_hsa004101.70444251
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70242259
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61357660
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60040952
30Caffeine metabolism_Homo sapiens_hsa002321.59277399
31Long-term potentiation_Homo sapiens_hsa047201.58690269
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53857899
33Nitrogen metabolism_Homo sapiens_hsa009101.52428290
34Amphetamine addiction_Homo sapiens_hsa050311.50484413
35Nicotine addiction_Homo sapiens_hsa050331.49906364
36Oxidative phosphorylation_Homo sapiens_hsa001901.48329797
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48175348
38Gastric acid secretion_Homo sapiens_hsa049711.44190788
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43446231
40Phenylalanine metabolism_Homo sapiens_hsa003601.39510115
41Calcium signaling pathway_Homo sapiens_hsa040201.38413110
42Starch and sucrose metabolism_Homo sapiens_hsa005001.37169778
43Parkinsons disease_Homo sapiens_hsa050121.34555012
44Oxytocin signaling pathway_Homo sapiens_hsa049211.34368439
45Glutamatergic synapse_Homo sapiens_hsa047241.31699117
46Morphine addiction_Homo sapiens_hsa050321.31489857
47Arginine and proline metabolism_Homo sapiens_hsa003301.31229252
48GABAergic synapse_Homo sapiens_hsa047271.28505775
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27510112
50Complement and coagulation cascades_Homo sapiens_hsa046101.27387347
51Salivary secretion_Homo sapiens_hsa049701.25462891
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.25398086
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22636643
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21355395
55Glucagon signaling pathway_Homo sapiens_hsa049221.21237972
56PPAR signaling pathway_Homo sapiens_hsa033201.20604902
57Chemical carcinogenesis_Homo sapiens_hsa052041.19351999
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15831126
59Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11865735
60Alzheimers disease_Homo sapiens_hsa050101.11523403
61Dopaminergic synapse_Homo sapiens_hsa047281.10757582
62Staphylococcus aureus infection_Homo sapiens_hsa051501.09400835
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09219317
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05789139
65cAMP signaling pathway_Homo sapiens_hsa040241.05413200
66Tyrosine metabolism_Homo sapiens_hsa003501.04523469
67Carbon metabolism_Homo sapiens_hsa012001.01416329
68Fat digestion and absorption_Homo sapiens_hsa049751.00463329
69Regulation of autophagy_Homo sapiens_hsa041401.00248834
70Cardiac muscle contraction_Homo sapiens_hsa042600.99902533
71Long-term depression_Homo sapiens_hsa047300.99663853
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98354995
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.96175566
74Insulin signaling pathway_Homo sapiens_hsa049100.95585668
75Cholinergic synapse_Homo sapiens_hsa047250.95387156
76Folate biosynthesis_Homo sapiens_hsa007900.95286560
77Pancreatic secretion_Homo sapiens_hsa049720.93836386
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.93271810
79Synaptic vesicle cycle_Homo sapiens_hsa047210.91445218
80Cocaine addiction_Homo sapiens_hsa050300.90632494
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89504894
82ABC transporters_Homo sapiens_hsa020100.89407141
83Bile secretion_Homo sapiens_hsa049760.87243527
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85328964
85Ether lipid metabolism_Homo sapiens_hsa005650.85067462
86Glycerolipid metabolism_Homo sapiens_hsa005610.84293377
87AMPK signaling pathway_Homo sapiens_hsa041520.82692633
88Type II diabetes mellitus_Homo sapiens_hsa049300.82613420
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81202720
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80533412
91Vitamin digestion and absorption_Homo sapiens_hsa049770.79849312
92GnRH signaling pathway_Homo sapiens_hsa049120.77447196
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77259384
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75799324
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74923338
96Retinol metabolism_Homo sapiens_hsa008300.74691444
97Serotonergic synapse_Homo sapiens_hsa047260.74331764
98Mineral absorption_Homo sapiens_hsa049780.72520675
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69840268
100Taste transduction_Homo sapiens_hsa047420.65112758
101Dilated cardiomyopathy_Homo sapiens_hsa054140.64543450
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63748986
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.63217025
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61910375
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61847627
106Linoleic acid metabolism_Homo sapiens_hsa005910.61620113
107Fatty acid biosynthesis_Homo sapiens_hsa000610.58376655
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.55618690
109Dorso-ventral axis formation_Homo sapiens_hsa043200.55403978
110Estrogen signaling pathway_Homo sapiens_hsa049150.54543113
111Olfactory transduction_Homo sapiens_hsa047400.53109930
112Inositol phosphate metabolism_Homo sapiens_hsa005620.52946683
113Tight junction_Homo sapiens_hsa045300.52485346
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52154995
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51269488
116Thyroid hormone synthesis_Homo sapiens_hsa049180.51251151
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50633215
118Gap junction_Homo sapiens_hsa045400.50437961
119Biosynthesis of amino acids_Homo sapiens_hsa012300.49032555
120Metabolic pathways_Homo sapiens_hsa011000.47677248
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47508202
122mTOR signaling pathway_Homo sapiens_hsa041500.47191006
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46278448
124Protein digestion and absorption_Homo sapiens_hsa049740.45104500
125Ovarian steroidogenesis_Homo sapiens_hsa049130.44422956
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42921703
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42051655
128Glutathione metabolism_Homo sapiens_hsa004800.41056123
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.41052845
130Insulin resistance_Homo sapiens_hsa049310.37410839
131Huntingtons disease_Homo sapiens_hsa050160.37312640
132Lysosome_Homo sapiens_hsa041420.35202739
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35045556
134Other glycan degradation_Homo sapiens_hsa005110.34805524
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32981098
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.31848308
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31738520
138B cell receptor signaling pathway_Homo sapiens_hsa046620.30888187
139Pertussis_Homo sapiens_hsa051330.30733121
140Protein export_Homo sapiens_hsa030600.30079516
141Viral myocarditis_Homo sapiens_hsa054160.29330553
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.27470093
143Rheumatoid arthritis_Homo sapiens_hsa053230.26006635
144Osteoclast differentiation_Homo sapiens_hsa043800.25392627
145Arachidonic acid metabolism_Homo sapiens_hsa005900.24981679
146Collecting duct acid secretion_Homo sapiens_hsa049660.20778024
147Leishmaniasis_Homo sapiens_hsa051400.20505319
148Toxoplasmosis_Homo sapiens_hsa051450.19735400
149Primary immunodeficiency_Homo sapiens_hsa053400.18923540
150NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17465377
151Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15979481
152Drug metabolism - other enzymes_Homo sapiens_hsa009830.15620326
153Amoebiasis_Homo sapiens_hsa051460.15469267
154RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14836761

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